Plant composition for treating nasal polyp and nasal gland hypertrophy and preparation method thereof

Abstract

The invention relates to the technical field of nasal disease treatment, in particular to a plant composition for treating nasal polyp and nasal gland hypertrophy, which is prepared from the following raw material medicines in parts by mass: 10 to 15 parts of flos magnoliae, 8 to 12 parts of radix angelicae, 10 to 20 parts of radix scutellariae, 15 to 25 parts of honeysuckle flower, 10 to 18 parts of fructus forsythiae, 5 to 10 parts of radix platycodonis, 3 to 8 parts of herba menthae, 10 to 20 parts of herba houttuyniae and 5 to 12 parts of herba centipedae. And the following active extraction components in parts by weight: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin and 1-4 parts of a frankincense serrata serrata extract. Nasal cavity inflammation and tissue edema are effectively relieved through a combined effect, firstly, flos magnoliae and radix angelicae in the formula can dissipate wind-cold, dredge nasal orifices and directly improve the ventilation function of the nasal cavity, meanwhile, radix scutellariae, honeysuckle and other medicinal materials clear away damp-heat toxin in the body through the effects of clearing away heat and drying dampness, inflammatory response is inhibited from the source, and the effect is remarkable. By matching with modern active ingredients such as bromelain and curcumin, the release of inflammatory mediators can be further blocked, and the capillary permeability is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of rhinopathy treatment, and particularly relates to a plant composition for treating nasal polyps and hypertrophy of nasal glands and a preparation method thereof. BACKGROUND

[0002] Nasal polyps and hypertrophy of nasal glands are common chronic inflammatory diseases in otolaryngology, and the clinical manifestations are nasal congestion, rhinorrhea, hyposmia, headache and other symptoms, which seriously affect the quality of life of patients. At present, the main treatment methods of western medicine are glucocorticoids, antihistamines or surgical resection. However, long-term use of hormones is prone to drug resistance and side effects, and surgical treatment has problems such as large trauma, high recurrence rate and the like.

[0003] In recent years, the effects of plant extracts in anti-inflammatory, anti-allergic and immune regulation have gradually been valued. Studies have shown that many plant ingredients have the effects of inhibiting the release of inflammatory mediators, reducing tissue edema and regulating immune function, and show good application prospects in the treatment of nasal inflammatory diseases. According to the authorized announcement number "CN120771221A", a traditional Chinese medicine composition for treating rhinitis is disclosed. The traditional Chinese medicine composition comprises: platycodon grandiflorum, bitter almond, dried tangerine or orange peel, immature bitter orange fruit, shiu-yaun, ephedra, radix trichosanthis, fritillaria thunbergii miq, licorice and loquat leaf. The traditional Chinese medicine composition can significantly relieve sneezing symptoms caused by allergic rhinitis, reduce the levels of histamine and specific IgE in serum, and improve the degree of nasal mucosa tissue lesions, and has broad application prospects.

[0004] And the authorized announcement number "CN114903943A" discloses a compound bear bile nasal spray, which comprises the following raw materials in parts by weight: honeysuckle 22-30 parts; fishy grass 20-25 parts; forsythia 16-20 parts; bear bile powder 10-15 parts; xanthium 6-10 parts; magnolia flower 7-9 parts; mirabilite 3-5 parts; mint 1-5 parts; deionized water 180-300 parts. The spray does not contain hormones and has no side effects on the nasal cavity, and can effectively treat rhinitis; it can also quickly eliminate inflammation and improve immunity. The application also provides another method for preparing the above-mentioned spray, which has simple and controllable production process, reliable product quality, and perfect quality standards. The finished product has good stability, long shelf life and is suitable for large-scale production.

[0005] There is no research in the prior art on combining natural ingredients with strong anti-inflammatory, antioxidant and immune regulation effects such as bromelain, quercetin, curcumin and boswellia serrata extract with traditional qi-unblocking traditional Chinese medicines such as magnolia and white peony to assist in the treatment of nasal polyps and hypertrophy of nasal glands. Therefore, it is necessary to design a plant composition with anti-inflammatory, detumescence, qi-unblocking and immune regulation effects, which is safe and non-irritating, to assist in the treatment of nasal polyps and hypertrophy of nasal glands. SUMMARY

[0006] The present application aims at solving the above-mentioned problems in the prior art and proposes a plant composition for treating nasal polyps and hypertrophy of nasal glands and a preparation method thereof.

[0007] To achieve the above-mentioned purpose, the present application adopts the following technical solution: a plant composition for treating nasal polyps and hypertrophy of nasal glands, which is composed of raw medicinal materials in the following mass parts: 10-15 parts of lonicera japonica, 8-12 parts of radix angelicae dahuricae, 10-20 parts of radix scutellariae, 15-25 parts of lonicera japonica, 10-18 parts of forsythia suspensa, 5-10 parts of platycodon grandiflorum, 3-8 parts of mentha haplocalyx, 10-20 parts of agastache rugosa, and 5-12 parts of eleusine indica; and the following active extraction components: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin, and 1-4 parts of boswellia serrata extract.

[0008] Preferably, the preferred mass parts of the raw medicinal materials are: 12 parts of lonicera japonica, 10 parts of radix angelicae dahuricae, 15 parts of radix scutellariae, 20 parts of lonicera japonica, 14 parts of forsythia suspensa, 8 parts of platycodon grandiflorum, 5 parts of mentha haplocalyx, 15 parts of agastache rugosa, and 8 parts of eleusine indica. The preferred mass parts of the active extraction components are: 2 parts of bromelain, 1 part of quercetin, 1 part of curcumin, and 2.5 parts of boswellia serrata extract.

[0009] Preferably, the radix scutellariae, lonicera japonica, forsythia suspensa, and agastache rugosa in the plant raw medicinal materials are dry powders of extracts obtained through a water extraction process, and the extraction method includes the following steps: a. The radix scutellariae, lonicera japonica, forsythia suspensa, and agastache rugosa are respectively crushed through a 40-mesh sieve and mixed according to a mass ratio; b. 8-12 times the amount of purified water is added, heated to 90-100℃, and refluxed for 2 times, each for 1.5-2 hours; c. The extraction liquids are combined, filtered, and concentrated under reduced pressure to a relative density of 1.10-1.20 of the extract; d. Spray drying is performed at an inlet temperature of 160-180℃ and an outlet temperature of 80-90℃ to obtain the mixed extract dry powder.

[0010] Preferably, in the water extraction process, the mixed mass ratio of the radix scutellariae, lonicera japonica, forsythia suspensa, and agastache rugosa is 15:20:14:15, the amount of water used for extraction is 10 times, the extraction temperature is 95℃, the extraction time is 1.5 hours each time, the spray drying inlet temperature is 170℃, and the outlet temperature is 85℃.

[0011] Preferably, the lonicera japonica, radix angelicae dahuricae, mentha haplocalyx, and eleusine indica are volatile oil extracts obtained through supercritical CO2 extraction, and the extraction conditions include: an extraction pressure of 25-30 MPa, an extraction temperature of 40-50℃, a separation pressure of 5-8 MPa, and a separation temperature of 30-40℃. Preferably, the lonicera japonica, radix angelicae dahuricae, mentha haplocalyx, and eleusine indica are volatile oil extracts obtained through supercritical CO2 extraction, and the extraction conditions include: an extraction pressure of 25-30 MPa, an extraction temperature of 40-50℃, a separation pressure of 5-8 MPa, and a separation temperature of 30-40℃. The flow rate is 25-35 L / h, and the extraction time is 2-3 hours.

[0012] Preferably, the supercritical In the extraction, the mass ratio of the mixture of lonicera japonica, radix angelicae dahuricae, mentha haplocalyx, and eriostachys is 12:10:5:8, the extraction pressure is 28 MPa, the extraction temperature is 45℃, the separation pressure is 6 MPa, and the separation temperature is 35℃, The flow rate is 30 L / h, and the extraction time is 2.5 hours.

[0013] Preferably, the platycodon grandiflorum is a saponin extract obtained by ethanol reflux extraction, and the extraction method comprises the following steps: a. The platycodon grandiflorum is crushed through a 50-mesh sieve, 70%-80% ethanol is added, and the solid-liquid ratio is 1:8-1:12; b. The temperature is heated to 75-85℃, and reflux extraction is performed twice, each time for 1-2 hours; c. The ethanol extract is combined, the ethanol is recovered, concentrated to a thick paste, vacuum dried, crushed through an 80-mesh sieve, and the platycodon grandiflorum extract is obtained.

[0014] Preferably, in the ethanol extraction of the platycodon grandiflorum, the ethanol concentration is 75%, the solid-liquid ratio is 1:10, the extraction temperature is 80℃, the extraction time is 1.5 hours each time, the vacuum drying temperature is 60℃, and the drying time is 6 hours.

[0015] Preferably, the preparation method of the plant composition for treating nasal polyps and hypertrophy of nasal glands comprises the following steps: S1. Preparation of water extraction component: weigh radix scutellariae, honeysuckle, forsythia, and houttuynia cordata according to the proportion, and prepare the mixed extract dry powder according to the water extraction process; S2. Preparation of volatile oil component: weigh lonicera japonica, radix angelicae dahuricae, mentha haplocalyx, and eriostachys according to the proportion, and extract the volatile oil according to the supercritical extraction process, and adopt β-cyclodextrin inclusion, the inclusion temperature is 50-60℃, the stirring speed is 300-400 rpm, and the inclusion time is 2 hours; S3. Preparation of platycodon grandiflorum extract: weigh platycodon grandiflorum according to the proportion, and prepare the platycodon grandiflorum saponin extract according to the ethanol reflux extraction process; S4. Mixing of active ingredients: weigh bromelain, quercetin, curcumin, and boswellia serrata extract according to the proportion; S5. Total mixing: mix the water extraction dry powder obtained in step S1, the volatile oil inclusion obtained in step S2, the platycodon grandiflorum extract obtained in step S3, and the active ingredients of step S4, put them into a three-dimensional motion mixer, mix for 30-45 minutes, and the rotation speed is 10-15 rpm, to obtain a uniform plant composition.

[0016] Preferably, the specific process of β-cyclodextrin inclusion in step S2 is as follows: the mass ratio of volatile oil to β-cyclodextrin is 1:8, the inclusion temperature is 55°C, the stirring speed is 350 rpm, the inclusion time is 2 hours, and the product is spray-dried after inclusion with an inlet air temperature of 120°C and an outlet air temperature of 60°C. The mixing time of the three-dimensional mixer in step S5 is 40 minutes and the rotation speed is 12 rpm.

[0017] The design scheme proposed in this invention has the following beneficial effects during application: 1. This invention effectively reduces nasal inflammation and tissue edema through combined action. First, the magnolia flower and angelica dahurica in the formula can dispel wind-cold and clear the nasal passages, directly improving nasal ventilation. At the same time, herbs such as scutellaria baicalensis and honeysuckle can clear damp-heat toxins from the body through their heat-clearing and dampness-drying effects, inhibiting the inflammatory response from the root. Combined with modern active ingredients such as bromelain and curcumin, it can further block the release of inflammatory mediators and reduce capillary permeability, thereby significantly relieving the congestion and swelling of the nasal mucosa and promoting the shrinkage of polyp tissue. 2. This invention employs a segmented extraction process to maximize the retention of active ingredients. For water-soluble components such as Scutellaria baicalensis, dynamic water extraction combined with spray drying technology is used to effectively extract antibacterial substances such as baicalin. For volatile components such as Magnolia biondii, supercritical extraction technology is used to completely retain terpene volatile oils. Then, cyclodextrin inclusion technology is used to form stable inclusion complexes to solve the problem of easy loss of volatile oils. For Platycodon grandiflorus, ethanol reflux method is used to specifically extract saponin components. The three processes complement each other to ensure that the bioactivity of various active ingredients is completely preserved and synergistically exerted. 3. This invention can comprehensively repair the nasal mucosal barrier function and prevent recurrence. The active ingredients contained in Houttuynia cordata and Forsythia suspensa can enhance local immune function and inhibit abnormal glandular hyperplasia. Frankincense extract and quercetin can promote the repair of mucosal epithelial cells and restore the normal ciliary movement function. Peppermint volatile oil can immediately relieve nasal discomfort. Flavonoids in Centipeda minima can regulate immune response. The combined effect of multiple components forms a long-term protective mechanism, which can enhance the nasal cavity defense ability while eliminating existing lesions and significantly reduce the probability of disease recurrence. Detailed Implementation

[0018] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0019] Example 1 A plant composition for treating nasal polyps and nasal adenoid hypertrophy, comprising the following raw materials in parts by weight: Magnolia biondii 10-15 parts, Angelica dahurica 8-12 parts, Scutellaria baicalensis 10-20 parts, Lonicera japonica 15-25 parts, Forsythia suspensa 10-18 parts, Platycodon grandiflorus 5-10 parts, Mentha haplocalyx 3-8 parts, Houttuynia cordata 10-20 parts, and Centipeda minima 5-12 parts. And the following active extracts: 1-3 parts bromelain, 0.5-2 parts quercetin, 0.5-1.5 parts curcumin, and 1-4 parts frankincense saw edge extract.

[0020] The preferred mass fractions of the raw materials are: 12 parts Magnolia biondii, 10 parts Angelica dahurica, 15 parts Scutellaria baicalensis, 20 parts Lonicera japonica, 14 parts Forsythia suspensa, 8 parts Platycodon grandiflorus, 5 parts Mentha haplocalyx, 15 parts Houttuynia cordata, and 8 parts Centipeda minima. The preferred mass fractions of the active extracts are: 2 parts bromelain, 1 part quercetin, 1 part curcumin, and 2.5 parts frankincense saw edge extract.

[0021] Among them, Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata in the herbal raw materials are extracts obtained through water extraction. The extraction method includes the following steps: a. Grind Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata into powder and pass them through a 40-mesh sieve, then mix them according to the mass ratio; b. Add 8-12 times the amount of purified water, heat to 90-100℃, and reflux extract twice, each time for 1.5-2 hours; c. Combine the extracts, filter, and concentrate under reduced pressure to obtain an extract with a relative density of 1.10-1.20; d. Spray drying: inlet air temperature 160-180℃, outlet air temperature 80-90℃, to obtain mixed extract dry powder.

[0022] In the water extraction process, the mass ratio of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata is 15:20:14:15, the amount of water used for extraction is 10 times the amount of water used, the extraction temperature is 95℃, the extraction time is 1.5 hours per extraction, the inlet air temperature for spray drying is 170℃, and the outlet air temperature is 85℃.

[0023] Among them, Magnolia biondii, Angelica dahurica, Mentha haplocalyx, and Centipeda minima have undergone supercritical processing. The volatile oil extract obtained by extraction was obtained under the following conditions: extraction pressure 25-30 MPa, extraction temperature 40-50℃, separation pressure 5-8 MPa, and separation temperature 30-40℃. The flow rate is 25-35 L / h, and the extraction time is 2-3 hours.

[0024] Among them, supercritical During extraction, the mass ratio of Magnolia biondii, Angelica dahurica, Mentha haplocalyx, and Centipeda minima was 12:10:5:8. The extraction pressure was 28 MPa, and the extraction temperature was 45℃. The separation pressure was 6 MPa, and the separation temperature was 35℃. The flow rate was 30 L / h, and the extraction time was 2.5 hours.

[0025] Among them, Platycodon grandiflorus is a saponin extract obtained by ethanol reflux extraction, and its extraction method includes: a. Crush the platycodon root and pass it through a 50-mesh sieve, then add 70%-80% ethanol, with a material-to-liquid ratio of 1:8-1:12; b. Heat to 75-85℃ and reflux extract twice, 1-2 hours each time; c. Combine the ethanol extracts, recover the ethanol, concentrate to a thick paste, vacuum dry, and pulverize through an 80-mesh sieve to obtain Platycodon grandiflorus extract.

[0026] In the ethanol extraction of Platycodon grandiflorus, the ethanol concentration was 75%, the material-to-liquid ratio was 1:10, the extraction temperature was 80℃, the extraction time was 1.5 hours per extraction, the vacuum drying temperature was 60℃, and the drying time was 6 hours.

[0027] The preparation method of the plant composition for treating nasal polyps and nasal adenoid hypertrophy includes the following steps: S1. Preparation of water-extractable components: Weigh out Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata according to the ratio, and prepare a mixed extract powder according to the water extraction process; S2. Preparation of volatile oil components: Weigh out Magnolia biondii, Angelica dahurica, Mentha haplocalyx, and Centipeda minima according to the specified ratio, and prepare the volatile oil components using supercritical fluid chromatography. The volatile oil was extracted using an extraction process and then encapsulated with β-cyclodextrin at an encapsulation temperature of 50-60℃, a stirring speed of 300-400rpm, and an encapsulation time of 2 hours. S3. Preparation of Platycodon grandiflorus extract: Weigh Platycodon grandiflorus according to the formula and prepare Platycodon grandiflorus saponin extract by ethanol reflux extraction process; S4. Mixed active ingredients: Weigh out bromelain, quercetin, curcumin, and frankincense saw blade extract according to the specified ratio; S5. General Mixing: Mix the water-extracted dry powder obtained in step S1, the volatile oil inclusion complex obtained in step S2, the Platycodon grandiflorus extract obtained in step S3, and the active ingredient obtained in step S4. Put them into a three-dimensional motion mixer and mix for 30-45 minutes at a speed of 10-15 rpm to obtain a uniform plant composition.

[0028] The specific process of β-cyclodextrin inclusion in step S2 is as follows: the mass ratio of volatile oil to β-cyclodextrin is 1:8, the inclusion temperature is 55℃, the stirring speed is 350rpm, the inclusion time is 2 hours, and the inclusion is spray-dried with an inlet air temperature of 120℃ and an outlet air temperature of 60℃. In step S5, the mixing time of the three-dimensional mixer is 40 minutes and the rotation speed is 12 rpm.

[0029] Example 2 The raw material ratio for preparing the plant composition is as follows: 12 parts Magnolia biondii, 10 parts Angelica dahurica, 15 parts Scutellaria baicalensis, 20 parts Lonicera japonica, 14 parts Forsythia suspensa, 8 parts Platycodon grandiflorus, 5 parts Mentha haplocalyx, 15 parts Houttuynia cordata, 8 parts Centipeda minima, 2 parts Bromelain, 1 part Quercetin, 1 part Curcumin, and 2.5 parts Serratus angustifolia extract.

[0030] Preparation method: S1. Preparation of water extract components: Take 15 parts of Scutellaria baicalensis, 20 parts of Lonicera japonica, 14 parts of Forsythia suspensa, and 15 parts of Houttuynia cordata, pulverize them through a 40-mesh sieve, mix them evenly, add 10 times the amount of purified water, heat to 95℃, reflux extract twice, 1.5 hours each time, combine the extracts, filter, concentrate under reduced pressure to an extract with a relative density of 1.15, spray dry at an inlet air temperature of 170℃ and an outlet air temperature of 85℃ to obtain a mixed extract powder; S2. Preparation of volatile oil components: Take 12 parts of Magnolia biondii, 10 parts of Angelica dahurica, 5 parts of Mentha haplocalyx, and 8 parts of Centipeda minima, mix them, and use supercritical fluid chromatography. Extraction conditions: extraction pressure 28 MPa, extraction temperature 45℃, separation pressure 6 MPa, separation temperature 35℃. The flow rate was 30 L / h, the extraction time was 2.5 hours, the volatile oil was collected, and it was included in the mixture at a mass ratio of volatile oil to β-cyclodextrin of 1:8. The inclusion temperature was 55℃, the stirring speed was 350 rpm, the inclusion time was 2 hours, and the mixture was spray-dried after inclusion. The inlet air temperature was 120℃ and the outlet air temperature was 60℃ to obtain the volatile oil inclusion complex. S3. Preparation of Platycodon grandiflorus extract: Take 8 parts of Platycodon grandiflorus, pulverize and pass through a 50-mesh sieve, add 10 times the amount of 75% ethanol, reflux at 80℃ twice, 1.5 hours each time, combine the extracts, recover the ethanol, concentrate to a thick paste, vacuum dry at 60℃ for 6 hours, pulverize and pass through an 80-mesh sieve to obtain Platycodon grandiflorus saponin extract. S4. Weigh the active ingredients: Weigh 2 parts of bromelain, 1 part of quercetin, 1 part of curcumin, and 2.5 parts of frankincense saw blade extract. S5. Total Mixing: Mix S1 water-extracted dry powder, S2 volatile oil inclusion complex, S3 Platycodon grandiflorus extract and S4 active ingredient, put them into a three-dimensional motion mixer, mix for 40 minutes at 12 rpm to obtain a uniform plant composition.

[0031] Example 3 The raw material ratio for preparing the plant composition is as follows: 10 parts Magnolia biondii, 8 parts Angelica dahurica, 10 parts Scutellaria baicalensis, 15 parts Lonicera japonica, 10 parts Forsythia suspensa, 5 parts Platycodon grandiflorus, 3 parts Mentha haplocalyx, 10 parts Houttuynia cordata, 5 parts Centipeda minima, 1 part bromelain, 0.5 parts quercetin, 0.5 parts curcumin, and 1 part frankincense saw edge extract.

[0032] The preparation method is the same as in Example 2, only the raw material ratio is adjusted.

[0033] Example 4 The raw material ratio for preparing the plant composition is as follows: 15 parts Magnolia biondii, 12 parts Angelica dahurica, 20 parts Scutellaria baicalensis, 25 parts Lonicera japonica, 18 parts Forsythia suspensa, 10 parts Platycodon grandiflorus, 8 parts Mentha haplocalyx, 20 parts Houttuynia cordata, 12 parts Centipeda minima, 3 parts bromelain, 2 parts quercetin, 1.5 parts curcumin, and 4 parts frankincense saw edge extract.

[0034] The preparation method is the same as in Example 2, only the raw material ratio is adjusted.

[0035] Comparative Example 1 Lacking the volatile oil components of Magnolia biondii and Angelica dahurica; Compared with Example 2, no volatile oil component was prepared, while the other components and preparation methods were the same.

[0036] Comparative Example 2 Lacking Scutellaria baicalensis and Lonicera japonica water extract components; Compared with Example 2, no water extract component was prepared, while the remaining components and preparation methods were the same.

[0037] Comparative Example 3 Lacking Platycodon grandiflorus extract; Compared with Example 2, Platycodon grandiflorus extract was not prepared, but the remaining components and preparation methods were the same.

[0038] Comparative Example 4 It lacks active ingredients, such as bromelain. Compared with Example 2, no bromelain, quercetin, curcumin, or frankincense saw edge extract were added, while the remaining components and preparation methods were the same.

[0039] Comparative Example 5 Traditional decoction process: All herbal medicines, except for the active ingredients, are decocted together with water for extraction, concentrated and dried, and then the active ingredients are added and mixed. Specifically, all herbal medicines are pulverized, decocted twice with water, concentrated and dried, and then the active ingredients are added and mixed.

[0040] Experimental Example 1 Evaluation of anti-inflammatory effects - mouse ear swelling model; Methods: Healthy ICR mice were randomly divided into a blank group, a model group, Example 2 to 4 groups, and Comparative Example 1 to 5 groups, with 10 mice in each group. Each group was administered the drug by gavage for 7 consecutive days. After the last administration, xylene was applied to the right ear to induce inflammation, and the left ear was used as a control. The mice were sacrificed 30 minutes later, and both ears were punched and weighed to calculate the degree of ear swelling and the inhibition rate.

[0041] result: Group Ear swelling (mg) Inhibition rate (%) Model group 12.5±1.2 - Example 2 5.2±0.8 58.4 Example 3 6.1±0.9 51.2 Example 4 5.8±0.7 53.6 Comparative Example 1 9.8±1.1 21.6 Comparative Example 2 10.2±1.0 18.4 Comparative Example 3 8.9±0.9 28.8 Comparative Example 4 9.5±1.0 24.0 Comparative Example 5 11.2±1.1 10.4 Conclusion: The anti-inflammatory effects of the two to four groups were significantly better than those of the comparative group, indicating that the composition of the present invention has a synergistic anti-inflammatory effect.

[0042] Experimental Example 2 In vitro antibacterial test: Staphylococcus aureus, Streptococcus pneumoniae; Methods: The diameter of the inhibition zone of each drug against common nasal pathogens was determined by the agar diffusion method, with a concentration of 100 mg / mL. result: Group S. aureus (mm) S. pneumoniae (mm) Example 2 18.5±1.2 16.8±1.0 Example 3 17.2±1.1 15.5±0.9 Example 4 18.0±1.0 16.2±1.1 Comparative Example 1 12.3±0.8 11.0±0.7 Comparative Example 2 10.5±0.6 9.8±0.5 Comparative Example 3 9.8±0.7 8.5±0.6 Conclusion: The composition of the present invention has a significant inhibitory effect on common pathogenic bacteria in the nose.

[0043] Experimental Example 3 Clinical efficacy observation; Methods: 120 patients with nasal polyps or nasal adenoid hypertrophy were randomly divided into 6 groups and given the preparations of Example 2 and Comparative Examples 1 to 5, respectively, twice a day for 4 consecutive weeks. The improvement of symptoms such as nasal congestion, runny nose, and loss of smell was observed, and the overall effective rate was evaluated.

[0044] result: Group Number of cases Effective Effective Ineffective Total effective rate (%) Example 2 20 12 6 2 90.0 Comparative Example 1 20 6 7 7 65.0 Comparative Example 2 20 5 6 9 55.0 Comparative Example 3 20 7 6 7 65.0 Comparative Example 4 20 6 5 9 55.0 Comparative Example 5 20 4 5 11 45.0 Conclusion: The overall effective rate of the Example 2 group was significantly higher than that of each comparative group, indicating that the composition of the present invention has significant advantages in clinical treatment.

[0045] The core effects of this treatment are: It exerts its therapeutic effect through multiple anti-inflammatory and anti-allergic mechanisms, utilizing various plant-based active ingredients to synergistically inhibit inflammatory mediators and regulate immune responses. Water extracts of Scutellaria baicalensis, Lonicera japonica, Forsythia suspensa, and Houttuynia cordata contain flavonoids, chlorogenic acid, and other components, which can inhibit histamine release and prostaglandin synthesis, reducing inflammatory exudation of the nasal mucosa. Volatile oils from Magnolia biondii and Angelica dahurica, etc., are absorbed through supercritical fluid extraction. The extract retains terpenoid compounds, which act directly on mucosal capillaries to reduce vascular permeability. The added bromelain breaks down fibrin at inflamed sites. Quercetin, as a natural antihistamine, blocks the binding of allergens to IgE. Curcumin inhibits the NF-κB signaling pathway. Acetyl-11-keto-β-boswellic acid from the frankincense saw blade extract targets the 5-lipoxygenase pathway. The extract powder obtained through water extraction and supercritical fluid extraction are also available. Different dosage forms, such as volatile oil extracts obtained through extraction, work together to form a comprehensive intervention from the initial stage to the development stage of inflammation; The therapeutic effect is achieved by improving nasal microcirculation and promoting tissue repair. In terms of regulating local blood circulation and promoting epithelial cell regeneration, the saponin D in Platycodon grandiflorus obtained by ethanol reflux extraction can enhance the frequency of ciliary movement. Combined with the cooling sensation produced by menthol in peppermint volatile oil, it can improve nasal ventilation. The taraxerol in Centipeda minima can stimulate the production of mucosal secretory immunoglobulin A and enhance local immunity. In the preparation process, by precisely controlling parameters such as the extraction temperature of 95℃ in the water extraction process and the air inlet temperature of 170℃ in the spray drying process, the heat-sensitive components such as isochlorogenic acid A in honeysuckle are effectively preserved. At the same time, the volatile oil components are treated with β-cyclodextrin inclusion technology. Under the conditions of inclusion temperature of 55℃ and stirring speed of 350rpm, a stable inclusion complex is formed, which prolongs the mucosal retention time of effective components such as magnolol in magnolia biondii. The process of mixing at 12rpm for 40 minutes in a three-dimensional motion mixer ensures that the components are evenly distributed and jointly promote the repair and functional recovery of diseased tissues. This treatment synergistically addresses nasal lesions through multiple antibacterial effects and mucus regulation. The antibacterial effect encompasses both direct inhibition of pathogenic microorganisms and regulation of nasal flora balance. Decanoyl acetaldehyde from Houttuynia cordata and forsythoside from Forsythia suspensa form a natural antibacterial complex, synergistically inhibiting common pathogens such as Staphylococcus aureus and Streptococcus pneumoniae. During preparation, parameters such as 10 times the amount of purified water and 1.5 hours of extraction time in the water extraction process were optimized to maximize the extraction of baicalin from Scutellaria baicalensis and phenylethanoid glycosides from Forsythia suspensa. Simultaneously, bromelain reduces nasal mucus viscosity through enzymatic hydrolysis, and combined with the expectorant effect of platycodon saponins, forms an effective mucus clearance system. Supercritical fluid extraction... The peppermint volatile oil obtained by the extraction process under the conditions of extraction pressure of 28MPa and extraction temperature of 45℃ contains menthone, which can stimulate the trigeminal nerve endings and reflexively promote glandular secretion and dilution. Finally, through the thorough mixing of the three-dimensional motion mixer, the water-soluble components and fat-soluble components are evenly dispersed, and together they maintain the ecological balance of the nasal cavity microenvironment.

[0046] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A plant composition for treating nasal polyps and hypertrophy of nasal glands, characterized by comprising: The plant composition is composed of the following mass parts of raw medicinal materials: 10-15 parts of lonicera japonica, 8-12 parts of radix angelicae pubescentis, 10-20 parts of radix scutellariae, 15-25 parts of lonicera japonica, 10-18 parts of forsythia suspensa, 5-10 parts of platycodon grandiflorum, 3-8 parts of mentha haplocalyx, 10-20 parts of houttuynia cordata, and 5-12 parts of euryscomus ferugineus; and the following active extraction ingredients: 1-3 parts of bromelain, 0.5-2 parts of quercetin, 0.5-1.5 parts of curcumin, and 1-4 parts of boswellia serrata extract.

2. The plant composition for treating nasal polyps and hypertrophy of nasal glands according to claim 1, characterized in that: The preferred mass parts of the raw medicinal materials are: 12 parts of lonicera japonica, 10 parts of radix angelicae pubescentis, 15 parts of radix scutellariae, 20 parts of lonicera japonica, 14 parts of forsythia suspensa, 8 parts of platycodon grandiflorum, 5 parts of mentha haplocalyx, 15 parts of houttuynia cordata, and 8 parts of euryscomus ferugineus. The preferred mass parts of the active extraction ingredients are: 2 parts of bromelain, 1 part of quercetin, 1 part of curcumin, and 2.5 parts of boswellia serrata extract.

3. The plant composition for treating nasal polyps and nasal adenoid hypertrophy according to claim 2, characterized in that: The radix scutellariae, lonicera japonica, forsythia suspensa, and houttuynia cordata in the plant raw medicinal materials are dry powders of extracts obtained through a water extraction process, and the extraction method comprises the following steps: a. grinding the radix scutellariae, lonicera japonica, forsythia suspensa, and houttuynia cordata separately to pass through a 40-mesh sieve, and mixing them according to a mass ratio; b. adding 8-12 times the amount of purified water, heating to 90-100°C, and refluxing extraction for 2 times, each for 1.5-2 hours; c. combining the extraction liquids, filtering, and concentrating under reduced pressure to a relative density of 1.10-1.20 of the extract; d. spray drying, with an inlet air temperature of 160-180°C and an outlet air temperature of 80-90°C, to obtain the dry powder of the mixed extract.

4. The plant composition for treating nasal polyps and nasal adenoid hypertrophy according to claim 3, characterized in that: In the water extraction process, the mixed mass ratio of the radix scutellariae, lonicera japonica, forsythia suspensa, and houttuynia cordata is 15:20:14:15, the amount of water used for extraction is 10 times, the extraction temperature is 95°C, the extraction time is 1.5 hours each time, the spray drying inlet air temperature is 170°C, and the outlet air temperature is 85°C.

5. The plant composition of claim 4 for treating nasal polyps and hypertrophy of nasal glands. The magnolia, white pyrite, mint, goose grass are obtained by supercritical extraction The volatile oil extract is obtained by extraction, and the extraction conditions include: extraction pressure 25-30 MPa, extraction temperature 40-50 ℃, separation pressure 5-8 MPa, separation temperature 30-40 ℃, The flow rate is 25-35 L / h, and the extraction time is 2-3 hours.

6. The plant composition of claim 5 for treating nasal polyps and hypertrophy of nasal glands. The supercritical In the extraction, the mixed mass ratio of the magnolia, the white peony root, the mint and the aspidistra elatior is 12:10:5:8, the extraction pressure is 28 MPa, the extraction temperature is 45℃, the separation pressure is 6 MPa, the separation temperature is 35℃, The flow rate is 30 L / h, and the extraction time is 2.5 hours.

7. The plant composition of claim 6 for treating nasal polyps and hypertrophy of nasal glands. The platycodon grandiflorum is a saponin extract obtained through ethanol reflux extraction, and the extraction method comprises the following steps: a. grinding the platycodon grandiflorum to pass through a 50-mesh sieve, adding 70%-80% ethanol, and setting the solid-liquid ratio to 1:8-1:12; b. heating to 75-85°C, and refluxing extraction for 2 times, each for 1-2 hours; c. combining the ethanol extraction liquids, recovering the ethanol, concentrating to a thick paste, vacuum drying, grinding to pass through an 80-mesh sieve, and obtaining the platycodon grandiflorum extract.

8. The plant composition for treating nasal polyps and hypertrophy of nasal glands according to claim 7, characterized in that: In the platycodon grandiflorum ethanol extraction, the ethanol concentration is 75%, the solid-liquid ratio is 1:10, the extraction temperature is 80°C, the extraction time is 1.5 hours each time, the vacuum drying temperature is 60°C, and the drying time is 6 hours.

9. The method for preparing the plant composition for treating nasal polyps and hypertrophy of nasal glands according to any one of claims 1-8, characterized in that: The preparation method of the plant composition for treating nasal polyps and hypertrophy of nasal glands comprises the following steps: S1. preparing a water extraction component: weighing the radix scutellariae, lonicera japonica, forsythia suspensa, and houttuynia cordata according to the proportions, and preparing the dry powder of the mixed extract according to the water extraction process; S2, preparation of volatile oil components: according to the proportion of Magnolia, Baiji, mint, goose grass, according to the supercritical extraction process to extract volatile oil, and β-cyclodextrin inclusion, inclusion temperature is 50-60℃, stirring speed 300-400rpm, inclusion time 2 hours; S3. preparing a platycodon grandiflorum extract: weighing the platycodon grandiflorum according to the proportions, and preparing the platycodon grandiflorum saponin extract according to the ethanol reflux extraction process; S4. mixing active ingredients: weighing bromelain, quercetin, curcumin, and boswellia serrata extract according to the proportions; S5, total mixing: the water extract powder obtained in step S1, the inclusion compound of volatile oil obtained in step S2, the extract of Platycodon grandiflorum obtained in step S3 and the active ingredient of step S4 are mixed and put into a three-dimensional motion mixer, mixed for 30-45 minutes at a speed of 10-15 rpm to obtain a uniform plant composition.

10. A method for preparing a plant composition for treating nasal polyps and nasal adenoid hypertrophy according to claim 9, characterized in that: The specific process of the β-cyclodextrin inclusion in step S2 is as follows: the mass ratio of volatile oil to β-cyclodextrin is 1:8, the inclusion temperature is 55°C, the stirring speed is 350 rpm, the inclusion time is 2 hours, and after inclusion, spray drying is performed at an inlet temperature of 120°C and an outlet temperature of 60°C; The mixing time of the three-dimensional mixer in step S5 is 40 minutes and the speed is 12 rpm.

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