Hair demineralizer compositions, methods and uses thereof

Abstract

The present disclosure provides a composition for preventing and removing metal deposits accumulated in hair and a method thereof. The hair demineralizer compositions described herein include one or more chelating agents effective to bind metals in hair under weakly alkaline conditions, such as a pH of about 6 to about 9. The hair demineralizer composition may further comprise one or more antioxidants and / or one or more anti-redeposition agents that further help mitigate the effects of accumulated metal deposits in the hair.

Description

[0001] Cross - reference to related applications

[0002] This application claims priority to U.S. Provisional Application No. 63 / 378,021, filed Sep. 30, 2022, the entire content of which is incorporated herein by reference.

[0003] Incorporation by reference

[0004] All publications, patents, and patent applications mentioned in this specification are incorporated herein by reference to the extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference. BACKGROUND OF THE INVENTION

[0005] Water hardness results from dissolved salts of various metals, including calcium (Ca 2+ ) and magnesium (Mg 2+ ). Hard water may also contain trace metals. When hard water evaporates, solid calcium carbonate (CaCO3), also known as scale, is formed. Water hardness levels vary significantly across the country and internationally. SUMMARY OF THE INVENTION

[0006] In one aspect, the present disclosure provides compositions and methods for demineralizing hair. In some embodiments, the composition is a hair demineralizing agent composition comprising one or more demineralizing agents and one or more antioxidants. In some embodiments, the composition has a pH of from about 6 to about 9.

[0007] Hard water has an adverse effect on hair and directly affects hair quality. At high concentrations, the various metal salts in hard water are difficult to wash out completely, resulting in the accumulation of minerals in the hair. The various metals in hard water may react with the chemicals in hair cleansing / processing products, rendering the products less effective. In some cases, the metals interfere with the uniformity of bleaching / whitening agents or hair coloring services, resulting in undesirable and streaky results. Mineral deposits formed by the metals in hard water may combine with hair cleansing / processing products to form contaminants that adhere to the hair. Frequent washing with hard water may cause these mineral deposits to accumulate, giving the hair a rough and dry texture. The effects of mineral deposits are exacerbated when peroxide is used for chemical treatment in whitening, hair coloring, or perming services. Additionally, these mineral deposits may cause the hair to appear dull, lackluster, or hazy. Accordingly, there is an unmet need for safe and effective demineralizing agent compositions and methods for demineralizing hair. A hair demineralizing agent composition can restore hair condition or improve hair processing by removing minerals from the hair.

[0008] In some aspects, the present disclosure provides a hair demineralizing agent composition comprising: one or more demineralizing agents; and one or more antioxidants. In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 9.

[0009] In some embodiments, each of the one or more demineralizing agents is bound to a primary metal, a secondary metal, or a combination of two or more thereof. In some embodiments, each of the one or more demineralizing agents is bound to a metal comprising calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Ce), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Rh), osmium (Os), or iridium (Ir), or a combination of two or more thereof. In some embodiments, the one or more demineralizing agents are bound to a metal selected from: calcium, magnesium, copper, iron, chromium, nickel, aluminum, lead, zinc, cadmium, mercury, arsenic, or a combination of two or more thereof.

[0010] In some embodiments, the hair demineralizing agent composition comprises at least 3 demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 4 demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 5 demineralizing agents.

[0011] In some embodiments, the one or more demineralizing agents are chelating agents or sequestrants.

[0012] In some embodiments, the one or more demineralizing agents include trisodium methylglycinediacetate (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamic acid diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediaminosuccinate, sodium thiosulfate, octanoyl hydroxamic acid, diisopropyl oxalate, disodium copper EDTA, hydroxyethyl ethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tri(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination of two or more thereof.

[0013] In some embodiments, at least one of the one or more demineralizing agents comprises tetrasodium EDTA.

[0014] In some embodiments, the hair demineralizing agent composition comprises at least two demineralizing agents.

[0015] In some embodiments, the one or more demineralizing agents include trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination of two or more thereof.

[0016] In some embodiments, the one or more antioxidants include carnosine, ascorbic acid, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, Daucus carota sativa root cell culture lysate, ammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract, Vitis vinifera / grape seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropin, Punica granatum peel / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin gallate (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, lipoic acid, or a combination of two or more thereof. In some embodiments, the one or more antioxidants are peptide-derived antioxidants. In some embodiments, the peptide-derived antioxidants are carnosine, valine-cysteine, diprolinine, diphenylalanine, or a combination of two or more thereof.

[0017] In some embodiments, the hair demineralizing agent composition comprises trisodium MGDA, sodium gluconate, tetrasodium EDTA, and carnosine.

[0018] In some embodiments, the hair demineralizing agent composition has a pH of from about 7 to about 8.

[0019] In some embodiments, the hair demineralizing agent composition comprises one or more surfactants. In some embodiments, the surfactant is a solubilizer. In some embodiments, the solubilizer is polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or a combination of two or more thereof.

[0020] In some embodiments, the surfactant is a detergent.

[0021] In some embodiments, the detergent is Sapindus mukorossi pericarp extract, potassium coco-hydrolyzed oat protein, Starmella bombicola / Brassica oil fermentation product, sophorolipid, rapeseed sophorolipid, rhamnolipid, glycolipid, lauramidopropyl hydroxysulfobetaine, lauryl hydroxysulfobetaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauryl sarcosinate, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 α-olefin sulfonate, benzethonium chloride, coconut oil amide propyl amine oxide, decyl amine oxide, decyl glucoside, lauryl glucoside, coconut glucoside, coconut oil amide propyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysulfobetaine, coconut oil amide propyl hydroxysulfobetaine, maltodextrin glucoside, hydrogenated starch hydrolysate, or a combination of two or more thereof.

[0022] In some embodiments, the hair demineralizing agent composition comprises one or more pH regulators. In some embodiments, the one or more pH regulators are lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, L-arginine, or a combination of two or more thereof.

[0023] In some embodiments, the hair demineralizing agent composition comprises one or more solvents.

[0024] In some embodiments, the one or more solvents include water, alcohol, isosorbide dimethyl ether, chlorotrifluoropropene, diol, triethyl citrate, or a combination of two or more thereof.

[0025] In some embodiments, the hair demineralizing agent composition comprises one or more anti-redeposition agents. In some embodiments, the one or more anti-redeposition agents comprise anionic-functionalized biopolymers having chelating ability. In some embodiments, the one or more anti-redeposition agents are sodium carboxymethyl inulin, xanthan gum, hydroxyethyl cellulose, hydroxymethyl cellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethyl cellulose, amylopectin, scleroglucan, guar gum, acacia senegal gum, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, or combinations thereof.

[0026] In some embodiments, the hair demineralizing agent composition further comprises one or more cosmetically or dermatologically acceptable excipients. In some embodiments, the one or more dermatologically acceptable excipients are perfume, preservative, or combinations thereof.

[0027] In some embodiments, the total concentration (% w / w) of the one or more demineralizing agents in the hair demineralizing agent is from about 0.1% to about 15%.

[0028] In some embodiments, the total concentration (w / w %) of the one or more demineralizing agents in the hair demineralizing agent is from about 0.1% to about 5%.

[0029] In some embodiments, the total concentration (% w / w) of the one or more antioxidants in the hair demineralizing agent composition is from about 0.1% to about 3%.

[0030] In another aspect, the present disclosure provides a method of demineralizing hair using the hair demineralizing agent composition disclosed herein.

[0031] In certain aspects, provided herein is a method of removing metals from hair, comprising administering a hair composition as described herein.

[0032] Based on the following detailed description, other aspects and advantages of the present disclosure will become apparent to those skilled in the art, in which only illustrative embodiments of the present disclosure are shown and described. As can be recognized, the present disclosure is capable of having other and different embodiments, and several details thereof can be modified in various obvious aspects, all of which do not depart from the present disclosure. Therefore, the drawings and description are to be regarded as illustrative in nature and not restrictive. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The novel features of the present disclosure are set forth in detail in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that illustrates embodiments in which the principles of the present disclosure are utilized, and to the accompanying drawings, in which:

[0034] Figures 1A - 1E FIG. 2 is a bar graph showing the average value of each element recorded on four hair samples evaluated by TOF-SIMS (Example 1) according to some embodiments of the present disclosure.

[0035] Figures 2A - 2E FIG. 3 shows the average value of each element recorded on four hair samples evaluated by TOF-SIMS (Example 2) according to some embodiments of the present disclosure.

[0036] Figures 3A - 3D FIG. 4 shows the average value of each element recorded on four hair samples evaluated by TOF-SIMS (Example 3) according to some embodiments of the present disclosure.

[0037] Figure 4 FIG. 5 shows the CIELAB system for measuring color according to some embodiments of the present disclosure.

[0038] Figure 5 FIG. 6 shows Δa after 5 pool treatment cycles and product use according to some embodiments of the present disclosure.

[0039] Figure 6 FIG. 7 shows the color change of units 1 and 2 after soaking and bleaching treatment in a contaminated hard water soak according to some embodiments of the present disclosure.

[0040] Figure 7 FIG. 8 shows the color change of units 3 and 4 after soaking and color treatment in a contaminated hard water soak according to some embodiments of the present disclosure. DETAILED DESCRIPTION

[0041] Water hardness comes from dissolved salts of various metals, including calcium (Ca 2+ ) and magnesium (Mg 2+ ). Example forms of these salts include bicarbonates (e.g., Ca(HCO3)2 or Mg(HCO3)2), sulfates (e.g., CaSO4 or MgSO4), and chlorides (e.g., CaCl2 or MgCl2). When hard water evaporates, solid calcium carbonate (CaCO3), also known as scale, is formed. Water hardness levels are typically reported in grains per gallon (gpg), parts per million (ppm), or milligrams per liter (mg / L). Table 1 shows water hardness levels and their representative concentrations.

[0042] Table 1. Water Hardness Levels

[0043] Hardness grade Metal content (mg / L) Metal content (gpg) Soft 0-17 <1.0 Slightly hard 17-60 1.0-3.5 Medium hard 61-120 3.5-7.0 Hard 121-180 7.0-10.5 Very hard >180 >10.5

[0044] There are significant differences in water hardness levels both nationally and internationally. For example, Portugal has naturally soft water, while the UK has very hard water. In some regions of the Middle East, the hardness exceeds 450 ppm (26 gpg).

[0045] Trace metals are also present at lower levels in tap water (both hard and soft). In some cases, the content of trace metals is 1 / 10 to 1 / 100 of the content of Mg 2+ and Ca 2+ . Non-limiting examples of trace metals include iron (Fe), copper (Cu), zinc (Zn), aluminum (Al), lead (Pb), nickel (Ni), cadmium (Cd), chromium (Cr), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os) and iridium (Ir). Elements at the edges of the periodic table, especially metals in groups IA and IIA, prefer specific charges (e.g., ionized Ca and Mg tend to carry a positive charge of 2+), while those in groups IB - VIIB in the middle (also known as transition metals) can carry different charges (e.g., Fe 2+ 、Fe 3+ 、Fe 4+ and Fe 6+ ). Therefore, these transition metals can participate in various oxidation-reduction (redox) reactions.

[0046] Trace metals are found in sources other than water. Some of these play important biological roles as macro minerals. These metals include Ca, Mg, Fe, Cu and Zn. Metals that are utilized or absorbed by the body may be removed during hair formation, where the metals ultimately enter the interior of the hair fiber. The metal content in hair is an indicator of biological levels and, in some cases, hair is used in forensics to monitor heavy metal exposure in the environment. In some cases, metals are found in consumer products. Example types of these metals include Cd, Ni, Pd, Fe, Cu and Al. In some cases, metals are found in pollutants. Examples of these metals include Hg, Pb, Cd and Al from cigarette smoke.

[0047] Hair proteins are naturally negatively charged. In some cases, alkaline conditions and oxidative damage can increase the negative charge on the hair, leading to an increased likelihood of metal deposits, as positively charged metal ions in water are attracted to and bind to the negatively charged hair proteins. These metals include Ca 2+ 、Mg 2+ and trace metal ions from hard and soft water. In some cases, sulfur-containing amino acids (such as cysteine, methionine) serve as binding sites for metal ions. When disulfide bonds are broken by chemical treatment (such as perming), free thiols that bind to metal ions are formed. In some cases, cysteic acid is formed by disrupting the oxidative chemistry to create additional binding sites for metal ions. Alkaline conditions are readily encountered, as the average pH of US household tap water is between 6.5 - 9.5, and most chemical services are carried out at a pH greater than 10 (in some cases exceeding 12).

[0048] Depending on the water source and quality, various factors can affect the binding of metals to hair. In some embodiments, the factors include pH, the size of the metal ion, the concentration of the metal ion, other metal ions present, the state of the metal ion (e.g., complex salt or free form), and the condition of the hair. The general trend of the binding affinity of metals to hair is: Zn 2+ >Fe 2 + >Hg 2+ >Cu 2+ >Pb 2+ >Cr 3+ >Cd 2+ >Ni 2+ >Al 2+ 。Moreover, hair has an affinity for heavy metals, which can damage human hair, and the use of hair as an alternative material for heavy metal purification in aqueous media has been proposed and studied.

[0049] Metal ions in hard water can directly affect hair quality. For example, metal ions produce mineral deposits that interfere with hair cleansing and / or treatment and overall management. As a result, the hair looks dull and lackluster, appears hazy and has a rough texture, or is dry and brittle. In some cases, metals interfere with the uniformity of bleaching / whitening agents or hair dyeing services, resulting in undesirable and streaky results. In some cases, metal ions can change the way various products adhere to or interact with hair. In some cases, trace metal ions can cause more significant damage. In some cases, trace metal ions can catalyze oxidation reactions, further exacerbating the collateral damage of oxidizing chemicals to hair. In some cases, sunlight (UV), atmospheric oxygen, pollution, or chemical treatment with peroxides in whitening, hair dyeing, or perming services can exacerbate the effects of trace metal ions. In some cases, during hair chemical treatment, trace metal ions can cause uneven and unpredictable color, smoking foil, or hair loss. In some cases, metals can change the color of hair or cause it to fade. For example, the green hair of swimmers is a twofold problem. Contrary to popular belief, the problem is not caused by chlorine itself, but by the presence of blue-green Cu 2+ ions in the hair. Chlorine, the active chemical in pool disinfectants, acts as a strong oxidant that oxidizes the proteins in hair, increasing its ability to bind Cu 2+ ions. Further exposure to UV light (such as when swimming outdoors) increases the damage and subsequently increases the number of negative charges in the hair, causing more Cu 2+ to bind to the hair, thus exacerbating the micro-green color of the hair.

[0050] Accordingly, there is a need for a demineralizing agent composition that can effectively and safely remove metal ion deposits from hair. More specifically, there is a need for a demineralizing agent composition that can effectively bind various metal ions found in hard water, including calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os), or iridium (Ir), or a combination of two or more thereof.

[0051] Definitions

[0052] Unless otherwise defined, all technical terms, symbols, and other technical and scientific terms or expressions used herein are intended to have the same meaning as commonly understood by one of ordinary skill in the art to which the claimed subject matter pertains. In some instances, terms having a commonly understood meaning are defined herein for clarity and / or for ease of reference, and such definitions contained herein are not necessarily to be construed as representing a substantial difference from the commonly understood meaning in the art.

[0053] Throughout this application, various embodiments may be presented in a range of forms. It should be understood that the description of ranges is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of the disclosure. Thus, a description of a range should be considered to specifically disclose all possible sub-ranges as well as individual numerical values within that range. For example, a description of a range such as 1 to 6 should be considered to specifically disclose sub-ranges (such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, 3 to 6, etc.) and individual numbers within that range (e.g., 1, 2, 3, 4, 5, and 6). This applies regardless of the width of the range.

[0054] As used in this specification and the claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. For example, the term "a sample" includes a plurality of samples, including mixtures thereof.

[0055] The terms "determining", "measuring", "evaluating", "assessing", "assaying", and "analyzing" are often used interchangeably herein to refer to forms of measurement. These terms include determining the presence of an element (e.g., detecting). These terms can include quantitative, qualitative, or both quantitative and qualitative determinations. An evaluation can be relative or absolute. In addition to determining whether something is present based on the context, "detecting the presence of..." can also include determining the amount of its presence.

[0056] As used herein, the term "about" or "approximately" when referring to a measurable value such as an amount or concentration, etc., is intended to cover variations of 20%, 10%, 5%, 1%, 0.5% or even 0.1% of the specified amount. For example, in accordance with the practice in the art, "about" can mean plus or minus 10%. Alternatively, "about" can mean a range of plus or minus 20%, plus or minus 10%, plus or minus 5% or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude of a certain value, up to 5-fold or up to 2-fold. In cases where a particular value can be described in the present application and claims, unless otherwise stated, the term "about" can be considered to cover the acceptable error range of the particular value. In addition, where ranges, sub-ranges or both can be provided, these ranges or sub-ranges can include the endpoints of these ranges or sub-ranges.

[0057] In cases where a value is described as a range, it is understood that such disclosure includes disclosure of all possible sub-ranges within such range and specific numerical values falling within such range, whether or not the specific numerical values or specific sub-ranges are explicitly stated.

[0058] The terms "comprise", "have" and "include" are open-ended linking verbs. Any form or tense of one or more of these verbs (such as "comprises", "comprising", "has", "having", "includes" and "including") is also open-ended. For example, any method that "comprises", "has" or "includes" one or more steps is not limited to having only these one or more steps and also covers other unlisted steps.

[0059] As used herein, the term "mixture" or "mixtures" is intended to include a simple combination of substances and any compounds that can be produced from their combination.

[0060] As used herein, the term "cosmetically acceptable" refers to those compounds, substances, compositions and / or dosage forms that are suitable for contact with human or animal tissue within the scope of reasonable medical judgment, without producing excessive toxicity, irritation, allergic reactions or other problems or complications, and commensurate with a reasonable benefit / risk ratio.

[0061] As used herein, the term "cosmetically or dermatologically acceptable" means that the composition or component is suitable for contact with human skin tissue without producing abnormal toxicity, incompatibility, instability, allergic reactions, etc.

[0062] As used herein, the terms "metal" and "metal ion" are used interchangeably and refer to elements in the periodic table. When referring to a metal, different valence states or oxidation states of the metal are included. In some embodiments, for example, iron can refer to Fe and can also refer to Fe + 、Fe 2+ 、Fe 3+ 、Fe 4+ ,or a mixture of Fe in its various oxidation states. For example, when referring to Fe, it can include a mixture of Fe 2+ and Fe 4+ 、a mixture of Fe 2+ and Fe 3+ ,or a mixture of Fe 2+ 、Fe 3+ 、Fe 4+ , and so on.

[0063] The section headings used herein are for organizational purposes only and should not be construed as limiting the subject matter described.

[0064] Hair demineralizing agent composition

[0065] Provided herein is a hair demineralizing agent composition for safely removing various metal ions found in water in hair. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents and one or more antioxidants. In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 9 or from about 7 to about 8. In some embodiments, one or more demineralizing agents bind to metal ions in hair or in water. In some embodiments, one or more demineralizing agents bind to metal ions in hair that has been exposed to hard water. In some embodiments, one or more demineralizing agents and one or more antioxidants act together to address the negative effects associated with metal deposits in hair.

[0066] In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents, one or more antioxidants, and one or more pH regulators. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents, one or more antioxidants, one or more pH regulators, and one or more solvents. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents, one or more antioxidants, one or more pH regulators, one or more solvents, and one or more surfactants. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents, one or more antioxidants, one or more pH regulators, one or more solvents, one or more surfactants, and one or more anti-redeposition agents. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents, one or more antioxidants, one or more pH regulators, one or more solvents, one or more surfactants, one or more anti-redeposition agents, and one or more cosmetic or dermatologically acceptable excipients. In some embodiments, the hair demineralizing agent composition comprises any combination of one or more demineralizing agents, one or more antioxidants, one or more pH regulators, one or more solvents, one or more surfactants, one or more anti-redeposition agents, and one or more cosmetic or dermatologically acceptable excipients.

[0067] In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents and one or more antioxidants. In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 9. In some embodiments, the hair demineralizing agent composition comprises two or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises three or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises four or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises five or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises one or more antioxidants. In some embodiments, the hair demineralizing agent composition comprises two or more antioxidants. In some embodiments, the hair demineralizing agent composition comprises three or more antioxidants.

[0068] In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 8. In some embodiments, the hair demineralizing agent composition has a pH of from about 7 to about 9. In some embodiments, the hair demineralizing agent composition has a pH of from about 7 to about 8.

[0069] In some embodiments, the hair demineralizing agent composition comprises one or more anti-redeposition agents. The anti-redeposition agent can interact with metal ions or metal ions complexed with the demineralizing agent. In some embodiments, the anti-redeposition agent can prevent the precipitation of metal ions or metal ions complexed with the demineralizing agent. In some embodiments, the anti-redeposition agent comprises multiple negative charges. In some cases, the multiple negative charges can interact with metal ions or metal ions complexed with the demineralizing agent.

[0070] In some embodiments, the hair demineralizing agent composition of the present disclosure is selected from Table 5, Table 6, Table 7, Table 8, or Table 10A.

[0071] Demineralizing agent

[0072] In some embodiments, the demineralizing agent described herein targets and binds to the primary metals found in hard water. The primary metals directly affect the texture, appearance, and structural integrity of hair fibers. In addition, the primary metals can limit the ability of various molecules and compounds to penetrate the hair, resulting in reduced efficacy of certain hair treatments. In some embodiments, the primary metals include calcium (Ca) and magnesium (Mg). The demineralizing agent described herein can also target and bind to the regenerated metals (trace metals) found in hard water. These regenerated metals increase the oxidation reactions on the surface and inside the hair, which may alter chemical treatments and increase the likelihood of damage to the hair during chemical treatments. In some embodiments, the regenerated metals include copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os), or iridium (Ir), or a combination of two or more thereof.

[0073] The demineralizing agent disclosed herein contains a chelating agent. The term "chelating agent" refers to a chemical compound that forms a stable water-soluble complex by tightly binding to metal ions. They are also referred to as chelants or chelators, and these terms are used interchangeably herein. In some embodiments, the demineralizing agent contains a chelating agent. In some embodiments, the chelating agent binds to metal ions by forming a molecular cage around the metal ions. In some embodiments, the chelating agent forms at least two bonds with a metal or metal ion. In some embodiments, the chelating agent coordinates with at least two sites on a metal or metal ion. In some embodiments, the demineralizing agent contains a multivalent chelating agent. In some embodiments, the multivalent chelating agent forms at least one bond with a metal or metal ion. In some embodiments, the multivalent chelating agent coordinates with at least one site on a metal or metal ion.

[0074] In some embodiments, the demineralizing agent binds irreversibly to metal ions. In some embodiments, one or more demineralizing agents bind to metal ions, which is described by an affinity constant such as the dissociation constant (K D )). The dissociation constant is defined as the ratio of the product of the unbound chelating agent and the unbound metal ion to the chelating agent-metal ion complex and is expressed in concentration units such as moles per liter (L). In some embodiments, the chelating agent binds irreversibly to metal ions, and the K D of the reaction can be less than about 1×10 -7 M. In some cases, the chelating agent binds to metal ions with the following K D : about 10×10 -9 M, about 9×10 -9 M, about 8×10 -9 M, about 7×10 -9 M, about 6×10 -9 M, about 5×10 -9 M, about 4×10 -9 M, about 3×10 -9 M, about 2×10 -9 M, about 1×10 -9 M, 10×10 -8 M, about 9×10 -8 M, about 8×10 -8 M, about 7×10 -8 M, about 6×10 -8 M, about 5×10 -8 M, about 4×10 -8 M, about 3×10 -8 M, about 2×10 -8 M, about 1×10 -8 M, 10×10 -7 M, about 9×10 -7M, about 8×10 -7 M, about 7×10 -7 M, about 6×10 -7 M, about 5×10 -7 M, about 4×10 -7 M, about 3×10 -7 M, about 2×10 -7 M, about 1×10 -7 M, 10×10 -6 M, about 9×10 -6 M, about 8×10 -6 M, about 7×10 -6 M, about 6×10 -6 M, about 5×10 -6 M, about 4×10 -6 M, about 3×10 -6 M, about 2×10 -6 M, about 1×10 -6 M, 10×10 -5 M, about 9×10 -5 M, about 8×10 -5 M, about 7×10 -5 M, about 6×10 -5 M, about 5×10 -5 M, about 4×10 -5 M, about 3×10 -5 M, about 2×10 -5 M or about 1×10 -5 M.

[0075] In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least one demineralizing agent. In some embodiments, the hair demineralizing agent composition comprises at least two demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least three demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least four demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least five demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least six demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least seven demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least eight demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least nine demineralizing agents. In some embodiments, the hair demineralizing agent composition described herein comprises a plurality of chelating agents that act synergistically to prevent and remove mineral deposits that accumulate in the hair.

[0076] In some embodiments, one or more demineralizing agents include tetrasodium ethylenediaminetetraacetate (EDTA). In some embodiments, one or more demineralizing agents include tetrasodium ethylenediaminetetraacetate (EDTA), sodium phytate, phytic acid, or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium ethylenediaminetetraacetate (EDTA), sodium phytate, phytic acid, sodium gluconate, or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium ethylenediaminetetraacetate (EDTA), trisodium methylglycinediacetate (MGDA), tetrasodium glutamic acid diacetate (GLDA), or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium methylglycinediacetate (MGDA), or a combination thereof. In some embodiments, one or more demineralizing agents include sodium phytate, sodium gluconate, trisodium methylglycinediacetate (MGDA), or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA, sodium gluconate, trisodium methylglycinediacetate (MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA, sodium phytate, sodium gluconate, trisodium methylglycinediacetate (MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium methylglycinediacetate (MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium methylglycinediacetate (MGDA), tetrasodium GLDA, or a combination thereof. Non-limiting examples of chelating agents include trisodium methylglycinediacetate (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamic acid diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediaminosuccinate, sodium thiosulfate, octanoyl hydroxamic acid, diisopropyl oxalate, disodium EDTA-copper, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination of two or more thereof.

[0077] In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 2 demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 3 demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 4 demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises at least 5 demineralizing agents.

[0078] In some embodiments, one or more demineralizing agents include chelating agents, polyvalent chelating agents, or combinations thereof. In some embodiments, one or more demineralizing agents are chelating agents or polyvalent chelating agents.

[0079] In some embodiments, one or more demineralizing agents comprise at least two demineralizing agents. In some embodiments, one or more demineralizing agents comprise trisodium methylglycinediacetate (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediamine succinate, sodium thiosulfate, octanohydroxamic acid, diisopropyl oxalate, disodium copper EDTA, hydroxyethyl ethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), or trisodium HEDTA, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and sodium phytate. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and phytic acid. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and sodium gluconate. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and tetrasodium GLDA. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and one of tetrasodium GLDA, tetrasodium EDTA, trisodium EDTA, or disodium EDTA. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and tetrasodium EDTA. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and pentasodium pentetic acid. In some embodiments, one or more demineralizing agents comprise tetrasodium EDTA and tetrasodium GLDA. In some embodiments, one or more demineralizing agents comprise disodium EDTA and tetrasodium EDTA. In some embodiments, one or more demineralizing agents comprise disodium EDTA and trisodium ethylenediamine succinate. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and sodium thiosulfate. In some embodiments, one or more demineralizing agents comprise trisodium MGDA and octanohydroxamic acid.

[0080] In some embodiments, one or more demineralizing agents comprise at least three demineralizing agents. In some embodiments, the at least three demineralizing agents comprise trisodium MGDA and at least two demineralizing agents selected from the group consisting of sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, trisodium ethylenediamine succinate, sodium thiosulfate, octanoyl hydroxamic acid, diisopropyl oxalate, disodium EDTA-copper, pentasodium pentetic acid, hydroxyethyl ethylenediamine triacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), or trisodium HEDTA, or combinations of two or more thereof. In some embodiments, the at least three demineralizing agents include pentasodium pentetic acid, trisodium MGDA, and sodium phytate. In some embodiments, the at least three demineralizing agents include tetrasodium GLDA, tetrasodium EDTA, or oxalic acid. In some embodiments, the at least three demineralizing agents include trisodium MGDA, sodium phytate, and sodium gluconate. In some embodiments, the at least three demineralizing agents include sodium phytate, sodium gluconate, and tetrasodium GLDA. In some embodiments, the at least three demineralizing agents include sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three demineralizing agents include sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three demineralizing agents include trisodium MGDA, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three demineralizing agents include trisodium MGDA, sodium gluconate, and tetrasodium EDTA. In some embodiments, the at least three demineralizing agents include trisodium MGDA, sodium gluconate, and tetrasodium GLDA. In some embodiments, the at least three demineralizing agents include trisodium MGDA, sodium gluconate, and potassium citrate. In some embodiments, the at least three demineralizing agents include sodium thiosulfate, sodium gluconate, and potassium citrate. In some embodiments, the at least three demineralizing agents include octanoyl hydroxamic acid, sodium gluconate, and potassium citrate. In some embodiments, the at least three demineralizing agents include sodium citrate, sodium gluconate, and potassium citrate. In some embodiments, the at least three demineralizing agents include trisodium HEDTA, sodium gluconate, and potassium citrate. In some embodiments, the at least three demineralizing agents include sodium thiosulfate, octanoyl hydroxamic acid, and diisopropyl oxalate.In some embodiments, the at least three demineralizing agents include trisodium methylglycinediacetate (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediamine disuccinate, sodium thiosulfate, octanohydroxamic acid, diisopropyl oxalate, disodium copper EDTA, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tri(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA) or trisodium HEDTA, or a combination of three or more thereof.

[0081] In some embodiments, one or more demineralizing agents comprise at least four demineralizing agents. In some embodiments, the at least four demineralizing agents comprise trisodium MGDA, sodium phytate, phytic acid and sodium gluconate. In some embodiments, the at least four demineralizing agents comprise trisodium MGDA, sodium phytate, sodium gluconate and tetrasodium GLDA. In some embodiments, the at least four demineralizing agents comprise trisodium MGDA, sodium gluconate, tetrasodium GLDA and tetrasodium EDTA. In some embodiments, the at least four demineralizing agents comprise sodium phytate, sodium gluconate, tetrasodium GLDA and tetrasodium EDTA. In some embodiments, the at least four demineralizing agents comprise sodium phytate, sodium phytate, tetrasodium GLDA and tetrasodium EDTA. In some embodiments, the at least four demineralizing agents include sodium phytate, sodium phytate, tetrasodium GLDA and tetrasodium EDTA. In some embodiments, the at least four demineralizing agents include tetrasodium EDTA, trisodium EDTA, disodium EDTA and sodium gluconate. In some embodiments, the at least four demineralizing agents include pentasodium pentetic acid, tetrasodium GLDA, trisodium MGDA and sodium phytate. In some embodiments, the at least four demineralizing agents include trisodium ethylenediamine disuccinate, sodium thiosulfate and diisopropyl oxalate. In some embodiments, the at least four demineralizing agents include disodium copper EDTA, oxalic acid, trisodium HEDTA and sodium citrate. In some embodiments, the at least four demineralizing agents include oxalic acid, trisodium HEDTA, sodium citrate and octanohydroxamic acid. In some embodiments, the at least four demineralizing agents include oxalic acid, trisodium HEDTA, sodium citrate and diisopropyl oxalate. In some embodiments, the at least four demineralizing agents include trisodium methylglycinediacetate (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediamine disuccinate, sodium thiosulfate, octanohydroxamic acid, diisopropyl oxalate, disodium copper EDTA, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tri(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA) or trisodium HEDTA, or a combination of four or more thereof.

[0082] In some embodiments, one or more demineralizing agents comprise at least five demineralizing agents. In some embodiments, the at least five demineralizing agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least five demineralizing agents comprise sodium phytate, phytic acid, sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least five demineralizing agents comprise sodium phytate, phytic acid, sodium gluconate, tetrasodium GLDA, and sodium citrate. In some embodiments, the at least five demineralizing agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, and sodium citrate. In some embodiments, the at least five demineralizing agents include trisodium MGDA, sodium citrate, sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least five demineralizing agents include sodium citrate, sodium gluconate, tetrasodium GLDA, octanoyl hydroxamic acid, and diisopropyl oxalate. In some embodiments, the at least five demineralizing agents include sodium citrate, potassium citrate, sodium gluconate, tetrasodium GLDA, and diisopropyl oxalate. In some embodiments, the at least five demineralizing agents include tetrasodium EDTA, sodium gluconate, tetrasodium GLDA, octanoyl hydroxamic acid, and diisopropyl oxalate. In some embodiments, the at least five demineralizing agents include tetrasodium EDTA, potassium citrate, sodium gluconate, tetrasodium GLDA, and diisopropyl oxalate. In some embodiments, the at least five demineralizing agents include trisodium MGDA, sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium EDTA, or a combination of five or more thereof. In some embodiments, the at least five demineralizing agents include trisodium dicarboxymethylglycine (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediamine succinate, sodium thiosulfate, octanoyl hydroxamic acid, diisopropyl oxalate, disodium EDTA-copper, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tri(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), or trisodium HEDTA, or a combination of five or more thereof.

[0083] In some embodiments, one or more demineralizing agents are selected based on their ability to complex with a metal. In some embodiments, one or more demineralizing agents are selected based on their ability to complex with virgin metal, recycled metal, or a combination thereof. In some embodiments, one or more demineralizing agents are selected based on their ability to complex with virgin metal. In some embodiments, one or more demineralizing agents complex with Ca, Mg, or a combination thereof. In some embodiments, one or more demineralizing agents are selected based on their ability to complex with recycled metal. In some embodiments, one or more demineralizing agents complex with Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, or Ir, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Ca, Mg, Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, or Ir, or a combination of two or more thereof. In some embodiments, the one or more demineralizing agents complex with Ca, Mg, Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, or Ir, or a combination of two or more thereof. In some embodiments, the one or more demineralizing agents complex with Ca, Mg, Cu, Cr, Fe, Al, Zn, Ni, Cd, Pb, or Hg, or a combination of two or more thereof. In some embodiments, the one or more demineralizing agents complex with Ca, Mg, Cu, Cr, Fe, Al, Zn, Ni, Cd, or Pb, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Ca, Mg, Cu, Fe, Mn, or Zn, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Ca, Mg, Cu, Fe, or Mn, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Ca, Mg, Fe, or Zn, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Ca, Fe, Co, or Zn, or a combination of two or more thereof. In some embodiments, one or more demineralizing agents complex with Na, Cu, Li, or a combination of two or more thereof.

[0084] In some embodiments, one or more demineralizing agents comprise trisodium MGDA, which complexes with multivalent metal ions. For example, trisodium MGDA complexes with Ca 2+ , Cu 2+ , Fe 3+ , Mg 2+ or Mn 2+ or a combination of two or more thereof. In some embodiments, one or more demineralizing agents comprise sodium phytate. For example, sodium phytate complexes with Ca 2+ , Mg 2+ , Fe 3+ or Zn 2+ or a combination of two or more thereof. In some embodiments, one or more demineralizing agents comprise sodium gluconate. For example, sodium gluconate coordinates or chelates with monovalent ions. The monovalent ion can be Na + , Cu + or a combination of two or more thereof. In some embodiments, one or more demineralizing agents comprise tetrasodium glutamate diacetate. For example, tetrasodium glutamate diacetate complexes with Ca 2+ , Cu 2+ , Fe 3 + , Mg 2+ , Mn 2+ or Zn 2+ or a combination of two or more thereof. In some embodiments, one or more demineralizing agents include tetrasodium EDTA. For example, tetrasodium EDTA complexes with Fe 3+ , Co 2+ , Zn 2+ or Ca 2+ or a combination of two or more thereof. In some embodiments, one or more demineralizing agents include sodium citrate or potassium citrate. For example, potassium citrate or sodium citrate complexes with Fe 2+ , Fe 3+ , Mn 2+ , Co 2+ or Al 3+ or a combination of two or more thereof. In some embodiments, one or more demineralizing agents include pentasodium pentetate. For example, pentasodium pentetate binds to Tc 4+ , Zn 2+ , Mg 2+ or Mn 2+ or a combination of two or more thereof.

[0085] In some embodiments, one or more demineralizing agents may carry a net negative charge. In some embodiments, one or more demineralizing agents may carry a total net negative charge corresponding to the sum of the net negative charges of each of the one or more demineralizing agents. In some embodiments, one or more demineralizing agents may carry a net negative charge in a pH range of from about pH 6 to about pH 9, from about pH 7 to about pH 8, from about pH 7 to about pH 9, or from about pH 6 to about pH 8. In some embodiments, the net negative charge of each of the one or more demineralizing agents within the pH range is -1, -2, -3, -4, or -5.

[0086] In some embodiments, the total concentration (% w / w) of one or more demineralizing agents in the hair demineralizing agent composition is from about 0.1% to about 15%. In some embodiments, the concentration (% w / w) of each of the one or more demineralizing agents in the hair demineralizing agent composition is about 0.05%, about 0.1%, about 0.2%, about 0.4%, about 0.6%, about 0.8%, about 1%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, or any value therebetween. In some embodiments, the total concentration (% w / w) of one or more demineralizing agents in the hair demineralizing agent composition is from about 0.1% to about 15%, from about 0.2% to about 14%, from about 0.4% to about 13%, from about 0.6% to about 12%, from about 0.8% to about 11%, from about 1% to about 10%, from about 1.2% to about 9%, from about 1.4% to about 8%, from about 1.6% to about 7%, from about 1.8% to about 6%, from about 2% to about 5%, or from about 3% to about 4%. In some embodiments, when two or more demineralizing agents are present, the concentration of each demineralizing agent may be the same. In some embodiments, when two or more demineralizing agents are present, the concentration of each demineralizing agent may be different.

[0087] In some embodiments, one or more demineralizing agents include trisodium MGDA, wherein trisodium MGDA is present in the composition in an amount of from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt%, or from about 0.9 wt% to about 1 wt%. For example, the trisodium MGDA is present in the composition in an amount of about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt% of the composition.

[0088] In some embodiments, one or more demineralizing agents include sodium phytate, wherein the sodium phytate is present in the composition in an amount of from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt%, or from about 0.9 wt% to about 1 wt%. For example, the sodium phytate is present in the composition in an amount of the following amounts of the composition: about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt%.

[0089] In some embodiments, one or more demineralizing agents include sodium gluconate, wherein sodium gluconate is present in the composition in an amount of from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt%, or from about 0.9 wt% to about 1 wt%. For example, sodium gluconate is present in the composition in an amount of the following amounts of the composition: about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt%.

[0090] In some embodiments, one or more demineralizing agents include tetrasodium glutamate diacetate, wherein tetrasodium glutamate diacetate is present in the composition in an amount of from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt%, or from about 0.9 wt% to about 1 wt%. For example, tetrasodium glutamate diacetate is present in the composition in an amount of from about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt% of the composition.

[0091] In some embodiments, one or more demineralizing agents include tetrasodium EDTA, wherein tetrasodium EDTA is present in the composition in an amount of from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt%, or from about 0.9 wt% to about 1 wt%. For example, tetrasodium EDTA is present in the composition in the following amounts of the composition: about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt%.

[0092] Antioxidant

[0093] Antioxidants are synthetic or naturally occurring molecules that inhibit oxidation reactions by neutralizing the unpaired electrons of free radicals through a resonance-stabilized bonding network. They act as reactive oxygen species (ROS) scavengers to reduce oxidative damage. Some non-limiting examples of antioxidants include vitamin C (ascorbic acid) and vitamin E (α-tocopherol). In some embodiments, one or more antioxidants can reduce oxidative reactions on the hair caused by regenerated (trace) metals that may remain after removal by the demineralizing agent. Most antioxidants are effective in reducing oxidation reactions under acidic conditions. In contrast, in some embodiments, one or more antioxidants act effectively under basic conditions to match the optimal activity of one or more demineralizing agents. In some embodiments, the optimal activity of one or more demineralizing agents includes binding to at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, or at least about 95% of the metal ions. In some embodiments, one or more antioxidants in the hair demineralizing agent composition of the present disclosure can be effective in the neutral or basic pH range. In some embodiments, one or more antioxidants in the hair demineralizing agent composition of the present disclosure can be effective at a pH of from about 6 to about 9 (e.g., at a pH of from about 7 to about 8).

[0094] In some embodiments, the hair demineralizing agent composition comprises one or more antioxidants. In some embodiments, the antioxidant comprises a peptide-derived antioxidant. In some embodiments, the peptide-derived antioxidant comprises phenylalanine, valine, cysteine, alanine, histidine, or a combination thereof. In some embodiments, the antioxidant comprises a dipeptide of alanine and histidine. In some embodiments, the peptide-derived antioxidant comprises carnosine, valine-cysteine, diprolinine, diphenylalanine, or a combination thereof. In some embodiments, the peptide-derived antioxidant comprises carnosine. In some embodiments, the antioxidant comprises carnosine, ascorbic acid, ascorbyl tetraisopalmitate, bioflavonoids, lycopene, carrot root cell culture lysate, ammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum extract, rosemary leaf extract, grape (Vitis vinifera / grape) seed extract, tea leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europaea (olive) leaf extract, oleuropein, pomegranate peel / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin gallate (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, or lipoic acid, or a combination of two or more thereof.

[0095] In some embodiments, the total concentration (% w / w) of one or more antioxidants in the hair demineralizing agent composition is from about 0.01% to about 5%. In some embodiments, the concentration (% w / w) of each of one or more antioxidants in the hair demineralizing agent composition is about 0.01%, about 0.02%, about 0.04%, about 0.06%, about 0.08%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, or any value therebetween. In some embodiments, the concentration (% w / w) of each of one or more antioxidants in the hair demineralizing agent composition is from about 0.01% to about 5%, from about 0.02% to about 4.5%, from about 0.04% to about 4%, from about 0.06% to about 3.5%, from about 0.08% to about 3%, from about 0.1% to about 2.5%, from about 0.5% to about 2%, or from about 1% to about 5%.

[0096] In some embodiments, the demineralizing agent composition comprises from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 5 wt%, from about 0.5 wt% to about 5 wt%, from about 1 wt% to about 5 wt%, from about 2 wt% to about 5 wt%, from about 1 wt% to about 2 wt% carnosine. For example, the carnosine is present in the composition in the following amounts of the composition: about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt% or about 5 wt%.

[0097] Anti-redeposition agent

[0098] The hair demineralizing agent composition may comprise one or more anti-redeposition agents. In some embodiments, the anti-redeposition agents disclosed herein are rheology modifiers or biodegradable functionalized biopolymers. In some embodiments, the anti-redeposition agent has a negative charge similar to that of hair or a chelating agent. In some embodiments, the anti-redeposition agent plays a role in the demineralizing ability of the hair demineralizing agent composition. In some embodiments, the anti-redeposition agent inhibits calcium carbonate (CaCO3) precipitation. In some embodiments, the anti-redeposition agent keeps metal ions dispersed in water so that the metal ions do not redeposit on the hair. In some embodiments, the anti-redeposition agent can prevent metal ions, metal / chelating agent complexes, or combinations thereof. In some embodiments, the anti-redeposition agent comprises a plurality of negatively charged groups. In some embodiments, the plurality of negatively charged groups coordinate with a metal or metal ion. In some embodiments, each of the plurality of negatively charged groups coordinates with a metal or metal ion. In some embodiments, at least two negatively charged groups coordinate with a metal or metal ion. In some embodiments, each of the plurality of negatively charged groups coordinates with at least one metal or metal ion. In some embodiments, the hair demineralizing agent composition comprises one or more anti-redeposition agents selected from: sodium carboxymethyl inulin, xanthan gum, hydroxyethyl cellulose, hydroxymethyl cellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethyl cellulose, amylopectin, scleroglucan, guar gum, gum arabic, sodium magnesium lithium silicate, or sodium magnesium fluorosilicate, or a combination of two or more thereof. In some embodiments, the anti-redeposition agent comprises sodium carboxymethyl inulin.

[0099] In some embodiments, the total concentration (% w / w) of one or more anti-redeposition agents in the hair demineralizing agent composition is from about 0.01% to about 10%. In some embodiments, the concentration (% w / w) of each of one or more anti-redeposition agents in the hair demineralizing agent composition is about 0.01%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10% or any value therebetween. In some embodiments, the concentration (% w / w) of one or more anti-redeposition agents in the hair demineralizing agent composition is from about 0.01% to about 10%, from about 0.05% to about 9.5%, from about 0.1% to about 9%, from about 0.2% to about 8.5%, from about 0.3% to about 8%, from about 0.4% to about 7.5%, from about 0.5% to about 7%, from about 0.6% to about 6.5%, from about 0.7% to about 6%, from about 0.8% to about 5.5%, from about 0.9% to about 5%, from about 1% to about 4.5%, from about 1.5% to about 4%, from about 2% to about 3.5% or from about 2.5% to about 3%.

[0100] In some embodiments, the demineralizing composition comprises sodium carboxymethyl inulin present in the composition in the following amounts: from about 0.005 wt% to about 5 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 0.6 wt% to about 2 wt%, from about 0.7 wt% to about 2 wt%, from about 0.8 wt% to about 2 wt%, from about 0.9 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 1.1 wt% to about 2 wt%, from about 1.2 wt% to about 2 wt%, from about 1.3 wt% to about 2 wt%, from about 1.4 wt% to about 2 wt%, from about 1.5 wt% to about 2 wt%, from 0.5 wt% to about 1 wt%, from about 0.6 wt% to about 1 wt%, from about 0.7 wt% to about 1 wt%, from about 0.8 wt% to about 1 wt% or from about 0.9 wt% to about 1 wt%. For example, sodium carboxymethyl inulin is present in the composition in the following amounts of the composition: about 0.005 wt%, 0.05 wt%, 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt% or about 5 wt%.

[0101] Surfactant

[0102] The hair demineralizing agent composition may comprise one or more surfactants. In some embodiments, the surfactant is a solubilizer. In some embodiments, the solubilizer comprises polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, or surfactin sodium, or a combination of two or more thereof. In some embodiments, the surfactant is a detergent. In some embodiments, the surfactant is a detergent comprising Sapindus mukorossi / soapnut pericarp extract, potassium coco-hydrolyzed oat protein, Candida bombicola / oleaginosus ferment extract, sophorolipid, rapeseed sophorolipid, rhamnolipid, glycolipid, lauramidopropyl hydroxysulfobetaine, lauryl hydroxysulfobetaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosinate, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 α-olefin sulfonate, benzethonium chloride, cocoamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, cocoyl glucoside, cocoamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysulfobetaine, cocamidopropyl hydroxysulfobetaine, maltodextrin glucoside, hydrogenated starch hydrolysate, or a combination thereof. In some embodiments, the detergent comprises a biosurfactant from soapnut. In some embodiments, the detergent comprises Sapindus mukorossi / soapnut extract. The soapnut extract is a source of saponins, which are biodegradable, making it a natural surfactant molecule with high environmental compatibility and low toxicity. The soapnut extract is effective in hard water due to its chelating ability and good foaming ability. It can be used for mild cleaning to assist in rinsing or washing away chelating agents.

[0103] In some embodiments, the total concentration (% w / w) of one or more surfactants in the hair demineralizing agent composition is from about 0.05% to about 30%. In some embodiments, the concentration (% w / w) of each of one or more surfactants in the hair demineralizing agent composition is about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 12%, about 14%, about 16%, about 18%, about 20%, about 22%, about 24%, about 26%, about 28%, about 30% or any value therebetween. In some embodiments, the concentration (% w / w) of one or more surfactants in the hair demineralizing agent composition is from about 0.05% to about 30%, from about 0.1% to about 28%, from about 0.5% to about 26%, from about 1% to about 24%, from about 1.5% to about 22%, from about 2% to about 20%, from about 2.5% to about 18%, from about 3% to about 16%, from about 3.5% to about 14%, from about 4% to about 12%, from about 4.5% to about 10%, from about 5% to about 9.5%, from about 5.5% to about 9%, from about 6% to about 8.5%, from about 6.5% to about 8%, or from about 7% to about 7.5%.

[0104] In some embodiments, the demineralizing agent composition comprises from about 0 wt% to about 5 wt%, from about 0.1 wt% to about 5 wt%, from about 0.5 wt% to about 5 wt%, from about 1 wt% to about 5 wt%, from about 2 wt% to about 5 wt%, from about 1 wt% to about 2 wt% of polysorbate 20. For example, polysorbate 20 is present in the composition in the following amounts of the composition: about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, about 2.5 wt%, about 3 wt%, about 3.5 wt%, about 4 wt%, about 4.5 wt% or about 5 wt%.

[0105] In some embodiments, the demineralizing agent composition comprises from about 0 wt% to about 5 wt%, from about 0.1 wt% to about 5 wt%, from about 0.5 wt% to about 5 wt%, from about 1 wt% to about 5 wt%, from about 2 wt% to about 5 wt%, from about 1 wt% to about 2 wt% of Sapindus peel extract. For example, the Sapindus peel extract is present in the composition in the following amounts of the composition: about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, about 2.5 wt%, about 3 wt%, about 3.5 wt%, about 4 wt%, about 4.5 wt% or about 5 wt%.

[0106] pH regulator

[0107] Primary metals and recycled metals are more soluble in acidic solutions. Thus, chelating agents are typically provided in compositions having an acidic pH. However, the specific chelating agents disclosed herein have been shown to be more effective under alkaline conditions. Accordingly, the present disclosure provides a hair demineralizing agent composition that is effective under alkaline pH conditions. In some embodiments, the hair demineralizing agent composition comprises one or more pH regulators to provide optimized pH conditions. In some embodiments, the hair demineralizing agent composition is effective under weakly alkaline conditions (at a pH of about 6 to about 9 or about 7 to about 8).

[0108] In some embodiments, the hair demineralizing agent composition has a pH of about 6, about 6.25, about 6.5, about 6.75, about 7, about 7.25, about 7.5, about 7.75, about 8, about 8.25, about 8.5, about 8.75, about 9 or any value therebetween. In some embodiments, the hair demineralizing agent composition has a pH of about 6 to about 9, about 6.25 to about 8.75, about 6.5 to about 8.5, about 6.75 to about 8.25, about 7 to about 8 or about 7.25 to about 7.75.

[0109] In some embodiments, one or more pH regulators may be present to adjust the pH of the hair composition. In some embodiments, the pH regulator may have a pK a . In some embodiments, the pK a of the pH regulator may be substantially the same as the pH of the hair composition. In some cases, the pH regulator may include a pK a of about 6 to about 9, about 6 to about 8, about 6 to about 7, about 7 to about 9, about 7 to 8 or about 8 to 9。In some embodiments, the pH regulator does not react with one or more demineralizing agents. In some embodiments, the pH regulator does not interact with one or more demineralizing agents. In some embodiments, one or more pH regulators include lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, or L-arginine, or a combination of two or more thereof. In some embodiments, one or more pH regulators include lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, or L-arginine, or a combination of two or more thereof.

[0110] In some embodiments, the total concentration (% w / w) of one or more pH regulators in the hair demineralizing agent composition is from about 0.01% to about 5%. In some embodiments, the concentration (% w / w) of each of one or more pH regulators in the hair demineralizing agent composition is about 0.01%, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, or any value therebetween. In some embodiments, the concentration (% w / w) of one or more pH regulators in the hair demineralizing agent composition is from about 0.01% to about 5%, from about 0.05% to about 4.5%, from about 0.1% to about 4%, from about 0.15% to about 3.5%, from about 0.2% to about 3%, from about 0.25% to about 2.5%, from about 0.3% to about 2%, from about 0.35% to about 1.5%, from about 0.4% to about 1%, from about 0.45% to about 0.95%, from about 0.5% to about 0.9%, from about 0.55% to about 0.85%, from about 0.6% to about 0.8%, from about 0.6% to about 0.75%, or from about 0.65% to about 0.7%.

[0111] In some embodiments, the demineralizing composition comprises lactic acid present in the composition in an amount of from about 0 wt% to about 2 wt%, from about 0.1 wt% to about 2 wt%, from about 0.5 wt% to about 2 wt%, from about 1 wt% to about 2 wt%, from about 0.05 wt% to about 1 wt%, from about 0.1 wt% to about 1 wt%, or from about 0.5 wt% to about 1 wt%. For example, lactic acid is present in the composition in the following amounts of the composition: about 0.1 wt%, about 0.2 wt%, about 0.3 wt%, about 0.4 wt%, about 0.5 wt%, about 0.6 wt%, about 0.7 wt%, about 0.8 wt%, about 0.9 wt%, about 1 wt%, about 1.1 wt%, about 1.2 wt%, about 1.3 wt%, about 1.4 wt%, about 1.5 wt%, about 1.6 wt%, about 1.8 wt%, about 1.9 wt%, about 2 wt%, or about 5 wt%.

[0112] Solvents and excipients

[0113] In some embodiments, the hair demineralizing agent composition comprises one or more solvents. In some embodiments, the one or more solvents comprise an aqueous solvent. In some embodiments, the one or more solvents comprise a polar solvent, a non-polar solvent, or a combination thereof. In some embodiments, the one or more solvents comprise water, an alcohol, a diol, an ester, an ether, a ketone, an organic acid, or a halogenated solvent, or a combination of two or more thereof. In some embodiments, the alcohol comprises methanol, ethanol, propanol, isopropanol, 1-butanol, 2-butanol, isobutanol, 1,4-butanediol, benzyl alcohol, or a combination of two or more thereof. In some embodiments, the diol comprises glycerol, ethylene glycol, or a combination thereof. In some embodiments, the esters include tert-butyl acetate, butyl acetate, ethylene carbonate, propyl acetate, dimethyl carbonate, ethyl acetate, ethyl propionate, methyl acetate, ethyl formate, or a combination of two or more thereof. In some embodiments, the ethers include diethylene glycol, anisole, diphenyl ether, dibutyl ether, tert-butyl ethyl ether, tert-amyl methyl ether, isosorbide dimethyl ether, phenetole, or a combination of two or more thereof. In some embodiments, the ketones include acetone, methyl ethyl ketone, cyclohexanone, cyclopentanone, or a combination of two or more thereof. In some embodiments, the organic acids include propionic acid, acetic anhydride, acetic acid, trimethyl citrate, triethyl citrate, or a combination of two or more thereof. In some embodiments, the halogenated solvents include chlorobenzene, trichloroacetonitrile, chloroacetic acid, chlorotrifluoropropene, or a combination of two or more thereof. In some embodiments, the one or more solvents include water and an alcohol. In some cases, the one or more solvents include water, methanol, or a combination thereof. In some cases, the one or more solvents include water, ethanol, or a combination thereof. In some embodiments, the one or more solvents include water, an alcohol, an ether, or a combination of two or more thereof. In some embodiments, the one or more solvents include water, an alcohol, an ether, an organic acid, or a combination of two or more thereof. In some embodiments, the one or more solvents include water, an alcohol, an ether, an organic acid, a halogenated solvent, or a combination of two or more thereof. In some embodiments, the one or more solvents include water, an alcohol, an ether, an organic acid, a halogenated solvent, or a combination of two or more thereof. In some embodiments, the one or more solvents include water, an alcohol, isosorbide dimethyl ether, chlorotrifluoropropene, a diol, triethyl citrate, or a combination of two or more thereof. In some embodiments, one or more solvents include water, an alcohol, a diol, or a combination of two or more thereof.

[0114] In some embodiments, the total concentration (% w / w) of one or more solvents or cosolvents in the hair demineralizing agent composition is from about 5% to about 90%. In some embodiments, the concentration of each of one or more solvents or cosolvents in the hair demineralizing agent composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, or any value therebetween. In some embodiments, the concentration of one or more solvents or cosolvents in the hair demineralizing agent composition is from about 5% to about 90%, from about 10% to about 85%, from about 15% to about 80%, from about 20% to about 75%, from about 25% to about 70%, from about 20% to about 65%, from about 25% to about 60%, from about 30% to about 55%, from about 35% to about 50%, or from about 40% to about 45%.

[0115] In some embodiments, the demineralizing composition comprises water present in the composition at from about 80 wt% to about 95 wt%, from about 80 wt% to about 85 wt%, from about 85 wt% to about 95 wt%, from about 90 wt% to about 95 wt%, or from about 85 wt% to about 90 wt%. For example, water is present in the composition in the following amounts of the composition: about 80 wt%, about 81 wt%, about 82 wt%, about 83 wt%, about 84 wt%, about 85 wt%, about 86 wt%, about 87 wt%, about 88 wt%, about 89 wt%, about 90 wt%, about 91 wt%, about 92 wt%, about 93 wt%, about 94 wt%, or about 95 wt%.

[0116] In some embodiments, the hair demineralizing agent composition comprises one or more cosmetically or dermatologically acceptable excipients. In some embodiments, the one or more cosmetically or dermatologically acceptable excipients include fragrances, preservatives, or combinations thereof. In some embodiments, the hair demineralizing agent composition further comprises one or more cosmetically or dermatologically acceptable excipients (including fragrances, preservatives, or combinations thereof). In some embodiments, the preservatives include gluconolactone, benzyl alcohol, calcium gluconate, sodium benzoate, phenoxyethanol, potassium sorbate, ethylhexylglycerin, caprylyl glycol, octanohydroxamic acid, or combinations of two or more thereof.

[0117] Method for Demineralizing Hair

[0118] The present disclosure also provides a method for demineralizing hair using the hair demineralizing agent composition disclosed herein.

[0119] In some embodiments, the method includes contacting a hair demineralizing agent composition as described herein with metal-containing water. In some embodiments, the metal includes virgin metal, recycled metal, or a combination thereof. In some embodiments, the water is hard water. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises one or more antioxidants. In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 9. In some embodiments, the method includes binding one or more demineralizing agents to the metal. In some embodiments, each of the one or more demineralizing agents binds to the metal. In some embodiments, binding of the one or more demineralizing agents includes removing from about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95%, about 99%, or about 100% of each metal in the water. In some embodiments, the one or more demineralizing agents remove from about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95%, about 99%, or about 100% of the total metal in the water.

[0120] In some embodiments, the method includes contacting a hair demineralizing agent composition as described herein with metal-containing hair. In some embodiments, the metal includes virgin metal, recycled metal, or a combination thereof. In some embodiments, the water is hard water. In some embodiments, the hair demineralizing agent composition comprises one or more demineralizing agents. In some embodiments, the hair demineralizing agent composition comprises one or more antioxidants. In some embodiments, the hair demineralizing agent composition has a pH of from about 6 to about 9. In some embodiments, the method includes binding one or more demineralizing agents to the metal. In some embodiments, each of the one or more demineralizing agents binds to the metal. In some embodiments, binding of the one or more demineralizing agents includes removing from about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95%, about 99%, or about 100% of each metal in the hair. In some embodiments, the one or more demineralizing agents remove from about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95%, about 99%, or about 100% of the total metal in the hair.

[0121] In some embodiments, a method of demineralizing hair comprises applying a demineralizing agent to the hair. In some embodiments, the method comprises leaving the demineralizing agent on the hair for several minutes. In some embodiments, the method comprises massaging or combing the hair to obtain an even coating. In some embodiments, the method comprises washing the hair with a hair cleansing product. In some embodiments, the method comprises thoroughly rinsing the hair. In some embodiments, the method comprises drying the hair. In some embodiments, a method of demineralizing hair comprises applying a demineralizing agent to the hair, leaving the demineralizing agent on the hair for several minutes, massaging or combing the hair to obtain an even coating, washing the hair with a hair cleansing product, thoroughly rinsing the hair, and drying the hair. In some embodiments, a method of demineralizing hair comprises applying a demineralizing agent to the hair, leaving it on the hair for several minutes, massaging or combing the hair to obtain an even coating, and proceeding directly to a chemical service. In some embodiments, a method of demineralizing hair comprises: applying a demineralizing agent to the hair, leaving it on the hair for several minutes, adding heat, massaging or combing the hair to obtain an even coating, and rinsing off or proceeding to a chemical service. In some embodiments, the demineralizing agent composition is added directly to the cleansing product.

[0122] In some cases, after applying the demineralizing agent to the hair, the demineralizing agent remains on the hair for about 1 minute, about 2 minutes, about 3 minutes, about 4 minutes, about 5 minutes, about 6 minutes, about 7 minutes, about 8 minutes, about 9 minutes, about 10 minutes, about 11 minutes, about 12 minutes, about 13 minutes, about 14 minutes, about 15 minutes, about 16 minutes, about 17 minutes, about 18 minutes, about 19 minutes, about 20 minutes, about 21 minutes, about 22 minutes, about 23 minutes, about 24 minutes, about 25 minutes, about 26 minutes, about 27 minutes, about 28 minutes, about 29 minutes, about 30 minutes, or any value therebetween. In some cases, after applying the demineralizing agent to the hair, the demineralizing agent remains on the hair for about 1 minute to about 30 minutes, about 2 minutes to about 29 minutes, about 3 minutes to about 28 minutes, about 4 minutes to about 27 minutes, about 5 minutes to about 26 minutes, about 6 minutes to about 25 minutes, about 7 minutes to about 24 minutes, about 8 minutes to about 23 minutes, about 9 minutes to about 22 minutes, about 10 minutes to about 21 minutes, about 11 minutes to about 20 minutes, about 12 minutes to about 19 minutes, about 13 minutes to about 18 minutes, about 14 minutes to about 17 minutes, or about 15 minutes to about 16 minutes.

[0123] In some embodiments, the method comprises contacting the hair with a hair demineralizing agent composition. In some embodiments, the method further comprises binding to about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95% or about 99% of the total metal ion concentration in the hair. In some embodiments, the method comprises binding to about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95% or about 99% of the nascent or regenerated metal in the hair as compared to untreated hair. In some embodiments, the method comprises providing a metal / demineralizing agent complex, wherein one or more demineralizing agents complex with metal ions to provide the metal / demineralizing agent complex. In some embodiments, one or more demineralizing agents provide a metal / demineralizing agent complex formed by complexing one or more demineralizing agents with about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95% or about 99% of the metal ions. In some embodiments, one or more demineralizing agents complex with about 10% to about 95%, about 20% to about 80%, about 30% to about 70%, about 40% to about 60%, about 10% to about 20%, about 10% to about 30%, about 10% to about 40%, about 10% to about 50%, about 10% to about 60%, about 10% to about 70%, about 10% to about 80%, about 10% to about 90%, about 20% to about 30%, about 20% to about 40%, about 20% to about 50%, about 20% to about 60%, about 20% to about 70%, about 20% to about 80% or about 20% to about 90% of the metal ions present in the hair prior to contact with the demineralizing agent composition.

[0124] In some embodiments, the method further comprises removing the metal / demineralizing agent complex. In some embodiments, removing the metal / demineralizing agent complex comprises washing the hair. In some cases, washing the hair comprises washing the hair with a hair cleansing product. In some embodiments, the method comprises removing a portion of the metal ions from the hair. In some embodiments, removing a portion of the metal ions from the hair is performed after washing the hair. In some embodiments, removing a portion of the metal ions from the hair comprises removing from about 10% to about 95%, about 20% to about 80%, about 30% to about 70%, about 40% to about 60%, about 10% to about 20%, about 10% to about 30%, about 10% to about 40%, about 10% to about 50%, about 10% to about 60%, about 10% to about 70%, about 10% to about 80%, about 10% to about 90%, about 20% to about 30%, about 20% to about 40%, about 20% to about 50%, about 20% to about 60%, about 20% to about 70%, about 20% to about 80%, or about 20% to about 90% of the metal ions from the hair. In some embodiments, the amount of metal ions removed from the hair can be determined by Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS).

[0125] In some embodiments, after applying the demineralizing agent to the hair, heat can be added to increase the reaction for more severe mineral build-up situations.

[0126] In some embodiments, the methods described herein can improve hair texture and shine. In some embodiments, the methods described herein can improve hair color. In some embodiments, the methods described herein can prevent or improve swimmer's hair. In some embodiments, the methods described herein can improve hair processing, including perming, straightening, bleaching, coloring, and using other hair care products (such as bond builders).

[0127] Examples

[0128] The following examples are included for illustrative purposes only and are not intended to limit the scope of the disclosure.

[0129] Example 1: Evaluation of specific elements on hair fibers by time - of - flight secondary ion mass spectrometry (TOF - SIMS) (I)

[0130] The presence of 10 elements on single hair fibers was evaluated before and after applying the exemplary hair demineralizing agent disclosed herein.

[0131] A total of 3 samples were used to treat 1 g of hair tress. The samples included demineralizing agent A (trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA; no antioxidant; pH 7 - 8), demineralizing agent B (trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA; no antioxidant; pH 4 - 5), and commercial product I (CP-I) (sodium gluconate and disodium EDTA). CP-I also contained ascorbic acid as an antioxidant. The whole pack of CP-I was mixed with 2 ounces of warm water. The bleached hair tress was rinsed 10 times with contaminated hard water containing a mixture of primary metals and recycled metals. The primary metals included but were not limited to Ca and Mg. The recycled metals included but were not limited to iron (Fe), copper (Cu), sodium (Na), aluminum (Al), lead (Pb), cadmium (Cd), chromium (Cr), and nickel (Ni). Then the hair tress was treated with demineralizing agent A or B as disclosed herein at 40% w / w of the total composition. The hair tress was massaged for 30 seconds and allowed to stand for 4 minutes, and then rinsed with ordinary water.

[0132] The samples tested included i) control hair fibers treated with contaminated hard water, ii) contaminated hair fibers treated with demineralizing agent A, iii) contaminated hair fibers treated with demineralizing agent B, and iv) contaminated hair fibers treated with CP-I.

[0133] The elements on the surface of the hair fibers analyzed by TOF-SIMS included iron (Fe), copper (Cu), sodium (Na), aluminum (Al), magnesium (Mg), lead (Pb), cadmium (Cd), chromium (Cr), nickel (Ni), and calcium (Ca).

[0134] TOF-SIMS utilizes secondary ion mass spectrometry of atomic species or low molecular weight fragments formed when a positively charged bismuth ion beam bombards the surface of a sample. The unique characteristic positive or negative ions of chemical compounds present at the beam impact point are analyzed according to the mass / charge ratio (m / z).

[0135] Three bleached hair tresses were rinsed 10 times with contaminated hard water. Three hair fibers were randomly selected for TOF-SIMS analysis (control). Then these hair tresses were treated with the products (demineralizing agent A, demineralizing agent B, and CP-I) and rinsed with ordinary water. Three hair fibers were randomly selected for TOF-SIMS analysis (after treatment). The samples were measured using a TOF-SIMS system (nanoTOFII, Physical Electronics) at 30 kV Bi + ions. During the analysis process, low energy electrons and Ar + ions (+ / - 10 eV) were used to maintain the charge neutrality of the sample surface.

[0136] TOF-SIMS images were recorded on three single fibers from samples of the control and three treatments (demineralizing agent A, demineralizing agent B, and CP-I). The distribution of ten target elements (Ca, Mg, Cu, Fe, Cd, Ni, Na, Al, Cr, and Pb) on the hair surface was obtained by calculating the relative amounts of each as determined in the MS.

[0137] TOF-SIMS images were recorded for: three hair fibers from a bleached hair bundle rinsed 10 times with "contaminated" hard water (control), three hair fibers from a contaminated hair bundle treated with demineralizing agent A, three hair fibers from a contaminated hair bundle treated with demineralizing agent B, and three hair fibers from a contaminated hair bundle treated with CP-I. Table 2 summarizes the average values of each element recorded on the four hair samples ( Figure 1A -E). The relative decrease (%) in the presence of metal ions compared to the control is presented.

[0138] Table 2. Average values of each element on the four hair samples

[0139]

[0140] Chelation of these elements associated with the three products tested showed significant differences depending on the element analyzed. Copper and lead on the hair surface were significantly reduced regardless of the product used for treatment. Based on these results, products demineralizing agent A and CP-I were the most effective in cleaning the metals on the hair surface. In fact, after treatment with CP-I, seven metals were reduced, and after treatment with demineralizing agent A, six metals were reduced. Product demineralizing agent B was still effective in cleaning the metal deposits on the hair surface, although less effective than demineralizing agent A and CP-I. The results in Table 2 indicate that demineralizing agent A was relatively more effective than the commercial product CP-I in removing regenerated metals including Cu 2+ 、Pb 2+ 、Cd 2+ and Ni 2+ . Demineralizing agent A was also relatively more effective than the commercial product CP-I in removing the primary metal Mg 2+ . Example 2: By time - of - flight secondary ion mass spectrometry (TOF - SIMS) Evaluation of specific elements (II) on hair fibers

[0141] The presence of 11 elements on single hair fibers was evaluated before and after applying the exemplary hair demineralizing agents disclosed herein.

[0142] Two samples were used to treat 1 g of hair tresses. The samples included the demineralizing agent C (trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium EDTA, carnosine) in Table 8 and CP-I. The entire packet of CP-I was mixed with 2 ounces of warm water. The bleached hair tresses were rinsed 10 times with the contaminated hard water. Then the hair tresses were treated with the exemplary demineralizing agent disclosed herein at 40% w / w. The hair tresses were massaged for 30 seconds and left standing for 4 minutes, and then rinsed with plain water.

[0143] The samples tested included i) control hair fibers treated 10 times with the contaminated hard water, ii) contaminated hair fibers treated with the demineralizing agent C of Table 8, and iii) contaminated hair fibers treated with CP-I.

[0144] The elements on the surface of the hair fibers analyzed by TOF-SIMS included iron (Fe), copper (Cu), zinc (Zn), aluminum (Al), magnesium (Mg), lead (Pb), cadmium (Cd), chromium (Cr), nickel (Ni), calcium (Ca), and mercury (Hg).

[0145] TOF-SIMS utilizes secondary ion mass spectrometry of atomic species or low molecular weight fragments formed when a positively charged bismuth ion beam bombards the surface of a sample. The unique characteristic positive or negative ions of the chemical compounds present at the beam impact point are analyzed according to the mass / charge ratio (m / z).

[0146] Three bleached hair tresses were rinsed 10 times with the contaminated hard water. Three hair fibers were randomly selected for TOF-SIMS analysis (control). Then these hair tresses were treated with the products (demineralizing agent C and CP-I) and rinsed with plain water. Three hair fibers were randomly selected for TOF-SIMS analysis (after treatment). The samples were measured using a TOF-SIMS system (nanoTOFII, Physical Electronics) at 30 kV Bi+ ions. During the analysis process, low energy electrons and Ar + ions (+ / - 10 eV) were used to keep the sample surface charge neutral.

[0147] TOF-SIMS images were recorded on 3 single fibers from the control (control / Control) and 3 treated samples (demineralizing agent C and CP-I in Table 8). The distribution of 11 target elements (Ca, Mg, Cu, Fe, Cd, Ni, Zn, Al, Hg, Cr, and Pb) on the hair surface was obtained by calculating the relative amount of each as determined in the MS spectra.

[0148] Recorded TOF-SIMS images of 3 hair fibers (control) from bleached hair bundles (rinsed 10 times with "contaminated" hard water), 3 hair fibers from contaminated hair bundles treated with demineralizer C, and 3 hair fibers from contaminated hair bundles treated with CP-I. Table 3 summarizes the average values of each element recorded on the three hair samples ( Figure 2A -E). Table 3 presents the relative reduction in the presence of metal ions relative to the control.

[0149] Table 3. Average values of each element on 3 hair samples

[0150]

[0151] Mercury is the least detected element detected on the hair fibers. Chelation of these elements associated with the two products tested showed significant differences depending on the element analyzed. Copper, lead, nickel, manganese, and zinc on the hair surface were significantly reduced regardless of the product used for treatment. Based on these results, the demineralizer product C of formulation in Table 8 is the most effective in cleaning the metals on the hair surface. In fact, after treatment with the demineralizer C of the formulation in Table 8, the concentrations of 7 metals including calcium were reduced. In this study, the product CP-I was the least effective in cleaning the metal deposits on the hair surface. Compared with CP-I, the demineralizer C in Table 8 removed more primary metals, as demonstrated by the higher relative reduction of Ca 2+ and Mg 2+ (29% and 48% respectively). Similarly, compared with CP-I, the demineralizer C in Table 8 also removed a larger portion of secondary metals such as Cu 2+ , Cr 2+ , Fe 2+ , Al 3+ , Zn 2+ , Cd 2+ and Pb 2+ . Example 3: Evaluation of specific elements (III) on hair fibers by time - of - flight secondary ion mass spectrometry (TOF - SIMS) Figure 3A

[0152] The presence of 12 elements on single hair fibers was evaluated before and after applying the hair demineralizers disclosed herein.

[0153] Three samples were used to treat 1 g of hair tresses. The samples included the hair demineralizing agent composition in Table 5 (such as Demineralizing Agent C in Table 6) (10 minutes), CP-I (30 minutes), and Commercial Product II (CP-II) (glycine, without antioxidant) (4 minutes). The CP-I package contains a chelating agent (sodium gluconate, disodium EDTA), an antioxidant (ascorbic acid), and an anti-redeposition agent (xanthan gum). CP-I is a low pH product. The entire package of CP-I was mixed with 2 ounces of warm water. The bleached hair tresses were rinsed 10 times with contaminated hard water. Then the hair tresses were treated with the exemplary hair demineralizing agent disclosed herein at 60% w / w. The hair tresses were massaged for 30 seconds and allowed to stand for 4 minutes, and then rinsed with ordinary water.

[0154] The samples tested included i) control hair fibers treated 10 times with contaminated hard water, ii) contaminated hair fibers treated with Demineralizing Agent C in Table 8, iii) contaminated hair fibers treated with CP-I, and iv) contaminated hair fibers treated with CP-II.

[0155] The elements on the surface of the hair fibers analyzed by TOF-SIMS included iron (Fe), copper (Cu), zinc (Zn), aluminum (Al), magnesium (Mg), lead (Pb), cadmium (Cd), chromium (Cr), nickel (Ni), calcium (Ca), arsenic (As), and mercury (Hg).

[0156] TOF-SIMS utilizes secondary ion mass spectrometry of atomic species or low molecular weight fragments formed when a positively charged bismuth ion beam bombards the surface of a sample. The unique characteristic positive or negative ions of chemical compounds present at the beam impact point are analyzed according to the mass / charge ratio (m / z).

[0157] Three bleached hair tresses were rinsed 10 times with contaminated hard water. Three hair fibers were randomly selected for TOF-SIMS analysis (control). Then these hair tresses were treated with the products (Demineralizing Agent C, CP-I, and CP-II in Table 8) and rinsed with ordinary water. Three hair fibers were randomly selected for TOF-SIMS analysis (after treatment). The samples were measured using a TOF-SIMS system (nanoTOFII, Physical Electronics) at 30 kV Bi+ ions. During the analysis process, low energy electrons and Ar+ ions (±10 eV) were used to keep the surface charge of the sample neutral.

[0158] TOF-SIMS images were recorded on three single fibers from the control (control / Control) and the three treated samples (Demineralizing Agent C, CP-I, and CP-II in Table 8). The distribution of 11 target elements (Ca, Mg, Cu, Fe, Cd, Ni, Zn, Al, Hg, Cr, and Pb) on the hair surface was obtained by calculating the relative amount of each as determined in the MS spectrum.

[0159] Record the TOF-SIMS images of 3 hair fibers (control) from bleached hair bundles (rinsed 10 times with "contaminated" hard water), 3 hair fibers from contaminated hair bundles treated with demineralizing agent C in Table 8, 3 hair fibers from contaminated hair bundles treated with CP-I, and 3 hair fibers from contaminated hair bundles treated with CP-II. Table 4 summarizes the average value of each element recorded on the four hair samples ( Example 4: Preparation of hair demineralizing agent -D). CP-I is as described above, and CP-II contains a chelating agent (glycine).

[0160] Table 4. Average value of each element on 3 hair samples

[0161]

[0162] Although the chemical composition of the custom hard water was changed, it was hoped to improve the visualization of some metals that are more difficult to image. Mercury (Hg 2+ ) is apparently still the least detected element on the hair fibers. The chelation of these metals associated with the three tested products showed significant differences depending on the metal analyzed. Copper, aluminum, nickel, and zinc on the hair surface were significantly reduced regardless of the product used for treatment. Based on these results, the demineralizing agent C formulation of the product is the most effective in cleaning the metals on the hair surface. In fact, after treatment with the demineralizing agent in Table 8, the concentrations of 8 metals including calcium were reduced. The relative reduction (%) of different metal ions in the hair compared to the control is presented in Table 4 above. In this study, CP-I was the least effective in cleaning the metal deposits on the hair surface.

[0163] Example 5: Prevention and removal of swimmers' hair color

[0164] Tables 5-8 provide hair demineralizing agent compositions. Exemplary hair demineralizing agent compositions are prepared by formulation and mixing techniques, or by mixing a solvent (water), a chelating agent, a surfactant, an anti-redeposition polymer or a rheology modifier, an antioxidant, a pH regulator, and a preservative together at an elevated temperature. The hair demineralizing agent compositions are as described in Table 5. The components are thoroughly mixed at an elevated temperature and then cooled to ambient temperature. In some cases, the components are completely mixed at room temperature. Other ingredients can be added to the cooled product. Unless otherwise specified, the amounts reflect the weight percentages of the active materials. The pH of demineralizing agent D, demineralizing agent E, and demineralizing agent C is each about 7 to about 8.

[0165] Table 5. Hair demineralizing agent composition

[0166]

[0167] Table 6. Hair demineralizing agent D composition

[0168]

[0169]

[0170] Table 7. Composition of Hair Demineralizer E

[0171]

[0172]

[0173] Table 8. Composition of Hair Demineralizer C

[0174]

[0175]

[0176] Figure 4

[0177] Ten bundles of European medium brown hair (3.0 g, 8” long, 1” wide) bleached with 9% paste were used for each treatment group.

[0178] The bleaching treatment protocol using Clairol Professional BW2 whitening agent and Salon Care clear 30vol developer is as follows: First, mix the powder bleach and developer in a weight ratio of 13:22, and bleach 6 bundles of hair per batch, so this will result in a usage of 15 g per bundle of hair. Apply the mixture evenly to both sides of the hair with a brush and massage the hair with fingers. Close the foil and place the hair in an oven at 40 ± 2 °C for 30 minutes. Manually operate for 2 minutes under tap water at 40 °C with a controlled flow rate of 1.0 GPM to thoroughly wash off the bleach on the hair. Dry the hair using medium heat and high speed settings. After the hair is dry, perform another bleaching cycle. Manually operate for 2 minutes under tap water set at 40 °C with a controlled flow rate of 1.0 GPM to thoroughly wash off the bleach on the hair. Apply 0.3 g of 15% SLES to each hair bundle. Massage the hair for 30 seconds and rinse for 30 seconds. All the hair is dried overnight at 60 ± 2 °C and 20 ± 2 °C.

[0179] A total of three test groups (3 units) were tested: Test group 1 (unit 1) was a control treated only with a sink and without washing. Test group 2 (unit 2) used only the demineralizer C in Table 8 once after 5 treatment cycles, and test group 3 (unit 3) used only the representative demineralizer C in Table 8 disclosed herein and a detoxifying shampoo once after 5 treatment cycles.

[0180] Each treatment was performed using an Intellifaucet set at approximately 40 °C and a flow rate of 1.0 GPM. The extreme simulated pool water consisted of deionized (DI) water, 4 ppm chlorine, and 0.5 ppm copper (the pool water manufacturer (AquaVet) recommends 1 ppm copper for pools, but this results in too dark a color). All test groups were soaked in the simulated pool water for one hour and then processed as follows: Test group 1 (Unit 1) had the hair air-dried and then began the next cycle, and color readings were taken on the dry hair after 5 treatment cycles. Test group 2 (Unit 2) had the hair air-dried before starting the next cycle. Only after the 5th cycle, on the dry hair, 60% w / w chelating agent was applied to the hair strands. The hair was massaged for 30 seconds, left for 4 minutes, rinsed for 30 seconds, and air-dried, and then color readings were taken. After 5 pool treatment cycles, followed by a single treatment with the chelating agent, color readings were taken on the dry hair. Test group 3 (Unit 3) had the hair air-dried and then began the next cycle. Only after the 5th cycle, on the dry hair, 60% w / w chelating agent was applied to the hair strands. The hair was massaged for 30 seconds, left for 4 minutes, and rinsed for 30 seconds. On the wet hair, 10% w / w shampoo was applied to the hair strands. The hair was massaged for 30 seconds, rinsed for 30 seconds, and air-dried, and then color readings were taken. After 5 treatment cycles, followed by a single treatment with the chelating agent (washing with a detoxifying agent), color readings were taken on the dry hair. For each treatment group, before the next cycle, the hair was dried overnight at 22 ± 2 °C, 60 ± 5% RH (relative humidity).

[0181] All bleached hair strands were labeled for identification. Baseline L, a, b measurements were taken using a Hunter Lab UltraScan VIS colorimeter to characterize the initial color of the hair. Technical hair color is typically quantified using the CIELAB L, a, b system (parameters are further elaborated in the appendix). This color is represented as a 3-dimensional matrix, where "L" represents lightness on a scale of 0 to 100, "a" represents the red-green range (positive values indicate higher red), and "b" represents the yellow-blue range (positive values indicate higher yellow). This is shown in Figure 5 . Typically, the change in hair color is evaluated by calculating the differences of these parameters relative to a reference state (i.e., ΔL * , Δa * and Δb * ). In addition, the overall color change ΔE is typically reported. That is

[0182] ΔE = √[ΔL *2 + Δa *2 + Δb *2However, in this study, the Δa parameter was used to evaluate the greenness of the hair. Ten (10) color measurements were made on each bundle of hair. Ten (10) bundles of hair for each treatment provided adequate statistical rigor. Box and whisker plots were generated using Statistica TM while statistical data (Student's t-test, confidence level 95%) were calculated using JMP TM analysis software. The data are given in the appendix. The test results are as Treatment shown in and Table 9A.

[0183] Table 9A. Results of color change

[0184] Average value N Standard deviation Standard error of the mean Unit 3 Unit 2 10 -8.8 0.8 0.2 Unit 1 10 -9.6 1.1 0.3 Example 6: Color absorption test 10 -12.5 0.6 0.2

[0185] When compared to the untreated, the following methods reduced the greenness of the hair in simulated pool water treatment: using only once the representative chelating agent and detoxifying shampoo disclosed herein after 5 treatment cycles, and using only once the representative chelating agent disclosed herein after 5 treatment cycles.

[0186] CIELAB L * a * b * parameters: The "L" scale measures the lightness or gray-scale component of a colored sample, where L = 0 represents black and L = 100 represents white. The ΔL value (the difference between after and before treatment) indicates whether the sample has become lighter (positive value) or darker (negative value) due to any treatment protocol. The "a" scale measures the chromaticity difference of the red-green component of the observed color. A positive change in a is associated with an increase in the red component. The "b" scale relates to the chromaticity difference of the yellow-blue component, and a positive change in it indicates an increase in yellow. Using these L, a, b values, other parameters can be calculated. The change in C (denoted by ΔC) represents the change in chromaticity. ΔE is a measure of the total color difference between the sample (after) and the sample (before). ΔH represents the change in hue.

[0187] C = (a 2 + b 2 ) 0.5

[0188] ΔC = (C 后 - C 前 )

[0189] ΔL = L 后 - L 前

[0190] ΔE = [(ΔL) 2 +(Δa) 2 + Δb) 2 0.5 ​

[0191] ΔH = [(ΔE) 2 -(ΔL) 2 -(△C) 2 0.5 ΔL is a good monitoring indicator for fading because it is a luminance parameter. It can be seen that ΔE (a parameter representing color change) is an excellent monitoring indicator for fading phenomena because its change is actually a "combination" of luminance and color changes. It covers more than one type of change in the fading phenomenon. Therefore, the change in ΔE is a good indicator of colorfastness under any research treatment protocol.

[0192] Dyeing treatment protocol

[0193] For each treatment group, 20 European medium brown hairs (3.0 g, 8" long, 1" wide) soaked in contaminated hard water and 20 bleached European medium brown hairs (3.0 g, 8" long, 1" wide) soaked in contaminated hard water were used. The contaminated hard water contains transition metals as well as calcium and magnesium salts.

[0194] Bleaching treatment protocol: Mix 1 part Clairol Professional BW2 hair powder whitener with 2 parts Salon Care 40 volume Crème developer. Add 10 g of the mixture to each hair bundle with a brush (5 g on each side) and massage the hair thoroughly. Place the hair on a heating plate maintained at 27 °C. Bleach the hair at 27 °C for 40 minutes. After 20 minutes (midway), turn the hair over and massage to make the coloring uniform. Rinse for 2 minutes (or until the water runs clear) under an Intellifaucet at 40 °C and a flow rate of 1.0 GPM. Let the hair sit for at least 12 hours.

[0195] Color fading test : Use a commercial hair dye and perform the coloring treatment on the hair bundles according to the procedure. Combine the color components according to the manufacturer's instructions and mix well. Add 10 g of the mixture to each hair bundle with a brush (5 g on each side) and massage the hair thoroughly. Place the hair on a heating plate maintained at 27 °C. Color the hair at 27 °C for 20 minutes. After 10 minutes (midway), turn the hair over and massage to make the coloring uniform. Rinse for 2 minutes (or until the water runs clear) under an Intellifaucet at 40 °C and a flow rate of 1.0 GPM. Let the hair sit for at least 12 hours before taking the post-coloring readings.

[0196] ​A total of four test groups (4 units) were tested: Test Group 1 (Unit 1) was treated with contaminated hard water and bleach (on virgin hair); Test Group 2 (Unit 2) was treated with contaminated hard water, Demineralizer C of Table 8, and bleach (on virgin hair); Test Group 3 (Unit 3) was treated with contaminated hard water and a dye (on bleached hair); and Test Group 4 (Unit 4) was treated with contaminated hard water, Demineralizer C of Table 8, and a dye (on bleached hair).

[0197] Each treatment was carried out using an Intellifaucet set at approximately 40 °C and a flow rate of 1.0 GPM. Three photographs were taken of all the hair, including before treatment with contaminated hard water, after treatment with contaminated hard water, and after application of the bleach / dye. The more detailed procedures for the test groups are as follows.

[0198] Color (L * A * B) change tests were performed on Units 1 and 2. The substrate for each unit was 3 g of 8” long, 1” wide European medium brown hair soaked in contaminated hard water. 10 hairs were used for each unit. The measurement time points occurred after soaking in contaminated hard water and after treatment. Unit 1 was treated with contaminated hard water + water + bleach. Unit 2 was treated with contaminated hard water + Demineralizer C in Table 8 + bleach. The contaminated hard water treatment involved soaking for 5 minutes, then blow-drying at low temperature and repeating 10 times. The hair was allowed to dry and equilibrated at 60% RH. For the application of the chelating agent (or water for the control unit), on dry hair, 60% w / w of Demineralizer C in Table 8 was applied to the hair bundle. The hair was massaged for 30 seconds, left for 4 minutes, not rinsed, and allowed to air dry, then bleached or dyed. The bleach application was carried out as follows: 1 part of Clairol Professional BW2 hair powder whitener was mixed with 2 parts of Salon Care 40 volume Crème developer. 10 g of the mixture was added to each hair bundle with a brush (5 g on each side), and the hair was massaged thoroughly. The hair was placed on a heating plate maintained at 27 °C. The hair was bleached at 27 °C for 40 minutes. The hair was turned over and massaged after 10 min (midway) to make the coloring uniform. It was rinsed for 2 minutes (or until the water ran clear) under an Intellifaucet at 40 °C and a flow rate of 1.0 GPM. And the hair was allowed to stand for at least 12 hours before taking the post-bleach readings.

[0199] Color (L * A *B) Variation Test. The substrate for each unit is 3g, 8” long, 1” wide European medium brown hair that has been bleached and soaked in contaminated hard water. 10 hairs were tested per unit. Measurement time points occurred after soaking in contaminated hard water and after treatment. Unit 3 was treated with contaminated hard water + water + dye. Unit 4 was treated with contaminated hard water + Demineralizer C of Table 8 + dye. The contaminated hard water treatment involved soaking for 5 minutes, then blow-drying at low temperature and repeating 10 times. Let the hair dry and equilibrate at 60% RH. The bleach application was carried out as follows: Mix 1 part Clairol Professional BW2 hair powder whitener with 2 parts Salon Care 40volume Crème developer. Add 10 grams of the mixture to each lock of hair (5g on each side) with a brush and massage the hair well. Place the hair on a heating plate maintained at 27°C. Bleach the hair at 27°C for 40 minutes. Flip the hair and massage it after 10 minutes (midway) to even out the coloring. Rinse for 2 minutes (or until the water runs clear) under an Intellifaucet at 40°C and a flow rate of 1.0 GPM. Let the hair sit for at least 12 hours. The chelating agent application (or water for the control unit) was carried out as follows: On dry hair, apply 60% w / w Demineralizer C of Table 8 to the lock of hair. Massage for 30 seconds. Let it sit for 4 minutes without rinsing. And let the hair air dry before bleaching or dyeing. The dye application was carried out as follows: The lock of hair was dyed using a commercial product according to the following procedure. Combine the color components according to the manufacturer's instructions and mix well. Add 10 grams of the mixture to each lock of hair (5g on each side) with a brush and massage the hair well. Place the hair on a heating plate maintained at 27°C. Dye the hair at 27°C for 20 minutes. Flip the hair after 10 minutes (midway) and massage to even out the coloring. Rinse for 2 minutes (or until the water runs clear) under an Intellifaucet at 40°C and a flow rate of 1.0 GPM. Let the hair sit for at least 12 hours before taking the post-dyeing readings. Let the hair equilibrate overnight at 22 ± 2°C, 60 ± 5% RH, and then take the time point measurements after soaking in hard water and after the dyeing / bleaching treatment.

[0200] Figure 4 : All dyed locks of hair were labeled for identification. Baseline L, a, b measurements were taken using a Hunter Lab UltraScan VIS colorimeter to characterize the initial color of the hair. Technical hair color is typically quantified using the CIELAB L, a, b system (parameters are further elaborated in the appendix). This color is represented as a 3-dimensional matrix where "L" represents lightness on a scale of 0 to 100, "a" represents the red-green range (positive values indicate higher red), and "b" represents the yellow-blue range (positive values indicate higher yellow). This is shown in Figure 6in the schematic diagram. Generally, the change in hair color is evaluated by calculating the differences of these parameters relative to a reference state (i.e., ΔL * , Δa * and Δb * ). In addition, the overall color change ΔE is usually reported. That is

[0201] ΔE = √[ΔL *2 + Δa *2 + Δb *2

[0202] Ten (10) color measurements are made for each bundle of hair. Ten (10) bundles of hair processed each time can provide appropriate statistical rigor. Box-and-whisker plots are generated using Statistica TM while statistical data (Student's t-test, confidence level is 95%) are calculated using JMP TM analysis software. The data are given in the appendix. The test results are as shown in Figure 7 , Example 7: Metal chelating ability of the formulation evaluated by qualitative water test strips and Table 9B.

[0203] Table 9B. Results of Color Change

[0204]

[0205]

[0206] After the hair is soaked in contaminated hard water and bleached, there is no statistical difference in the overall color change (ΔE) between the hair treated with DI water and the hair treated with a chelating agent in Unit 1 and Unit 2. This indicates that the demineralizing agent C in Table 8 does not affect the enhancement effect, volume, or processing time of the bleaching / brightening service.

[0207] After the hair is soaked in contaminated hard water and dyed, when comparing Unit 3 and 4 (the hair bundles treated with DI water and the demineralizing agent C in Table 8), there is a statistical difference in the overall color change ΔE. Applying hair dye on untreated hair is significantly darker than applying hair dye on hair treated with a chelating agent. This indicates that using the demineralizing agent C in Table 8 helps to achieve optimal color deposition for a more true and vivid color.

[0208] Test solution, test strip and evaluation

[0209] ​ ​— Pre - allocate 50 g of each solution into medium - sized weighing dishes for test strip evaluation. For the positive control and negative control, measure 100% pure solutions of contaminated hard water (as detailed in the previous section of the article) and ASTM type II deionized water, respectively. For the test groups, prior to test strip evaluation, pre - mix the contaminated hard water solution and the chelating agent formulation as follows: Dispense 30 g of contaminated hard water and 20 g of the chelating agent formulation into the weighing dish and manually mix for 10 seconds. This was determined to be the most effective method to quantify the chelating agent performance through test strip measurements.

[0210] Obtain water test strips with color indicator panels from Amazon. The indicator panels can show water hardness and the presence of certain trace metals. According to the instructions on the water test kit, dip each strip into the solution to be tested for approximately 2 seconds and then remove it. Perform color comparison evaluation 15 seconds after removing from the solution, noting that the color is no longer representative once it dries. The side of the test strip container depicts standard representative color calibrations to estimate the content of each indicated compound. Qualitative color comparisons are made by eye and converted into the data reported in Table 10A. The data reports the performance of the compositions and formulations as the reduction of the detected metals relative to the positive control - the more asterisks indicate a greater change (more significant reduction) of the detected metals compared to the contaminated hard water (CHW) control, as shown in Table 10B.

[0211] The results of the test strip chelation experiment are shown in Table 10A, and Table 10B presents an explanatory note of the results in Table 10A. The study shows that the compositions modified in different ways in Table 10A have different degrees of metal chelation, as indicated by the color - indicating water test strips.

[0212] Table 10A. Qualitative water test strip results of the formulations

[0213]

[0214]

[0215] Table 10B. Legend for Table 10A

[0216]

[0217] Although the preferred embodiments of the present disclosure have been shown and described herein, it will be apparent to those skilled in the art that these embodiments are provided by way of example only. Those skilled in the art will now conceive of many variations, changes, and substitutions without departing from the present disclosure. It should be understood that various alternatives to the embodiments of the present disclosure described herein may be employed in practicing the present disclosure. The following claims are intended to define the scope of the present disclosure and are intended to cover methods and structures within the scope of these claims and their equivalents.

Claims

1. A hair demineralizing agent composition, comprising: One or more demineralizing agents; and One or more antioxidants; Among them, The hair demineralizing agent composition has a pH of about 6 to about 9.

2. The hair demineralizing agent composition according to claim 1, wherein each of the one or more demineralizing agents is combined with a primary metal, a recycled metal, or a combination of two or more thereof.

3. The hair demineralizing agent composition according to claim 1, wherein each of the one or more demineralizing agents is combined with a metal, the metal including calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Ce), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Rh), osmium (Os), or iridium (Ir), or a combination of two or more thereof.

4. The hair demineralizing agent composition according to claim 1 or 2, wherein the one or more demineralizing agents are combined with a metal selected from: calcium, magnesium, copper, iron, chromium, nickel, aluminum, lead, zinc, cadmium, mercury, arsenic, or a combination of two or more thereof.

5. The hair demineralizing agent composition according to any one of claims 1-4, wherein the hair demineralizing agent composition comprises at least 3 demineralizing agents.

6. The hair demineralizing agent composition according to any one of claims 1-5, wherein the hair demineralizing agent composition comprises at least 4 demineralizing agents.

7. The hair demineralizing agent composition according to any one of claims 1-6, wherein the hair demineralizing agent composition comprises at least 5 demineralizing agents.

8. The hair demineralizing agent composition according to any one of claims 1-7, wherein the one or more demineralizing agents are chelating agents or multivalent chelating agents.

9. The hair demineralizing agent composition according to any one of claims 1-8, wherein the one or more demineralizing agents include trisodium dicarboxymethyl alanine (MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (GLDA), tetrasodium ethylenediaminetetraacetate (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetic acid, trisodium ethylenediaminosuccinate, sodium thiosulfate, octanoyl hydroxamic acid, diisopropyl oxalate, disodium EDTA-copper, hydroxyethyl ethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tri(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination of two or more thereof.

10. The hair demineralizing agent composition according to any one of claims 1-9, wherein at least one of the one or more demineralizing agents comprises tetrasodium EDTA.

11. The hair demineralizing agent composition according to any one of claims 1-10, which comprises at least two demineralizing agents.

12. The hair demineralizing agent composition according to any one of claims 1-9, wherein the one or more demineralizing agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination of two or more thereof.

13. The hair demineralizing agent according to any one of claims 1-12, wherein the one or more antioxidants comprise carnosine, ascorbic acid, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, carrot root cell culture lysate, ammonium glycyrrhizinate, alpha-lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract, Vitis vinifera / grape seed extract, tea tree leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europaea (olive) leaf extract, oleuropein, pomegranate peel / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, lipoic acid, or a combination of two or more thereof.

14. The hair demineralizing agent composition according to any one of claims 1-13, wherein the one or more antioxidants are peptide-derived antioxidants.

15. The hair demineralizing agent composition according to claim 14, wherein the peptide-derived antioxidant is carnosine, valine-cysteine, diprolinine, diphenylalanine, or a combination of two or more thereof.

16. The hair demineralizing agent composition according to any one of claims 1-14, which comprises trisodium MGDA, sodium gluconate, tetrasodium EDTA, and carnosine.

17. The hair demineralizing agent composition according to claim 16, wherein the hair demineralizing agent composition has a pH of about 7 to about 8.

18. The hair demineralizing agent composition according to any one of claims 1-17, further comprising one or more surfactants.

19. The hair demineralizing agent composition according to claim 18, wherein the surfactant is a solubilizer.

20. The hair demineralizing agent composition according to claim 19, wherein the solubilizer is polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, surfactin sodium, or a combination of two or more thereof.

21. The hair demineralizing agent composition according to claim 18, wherein the surfactant is a detergent.

22. The hair demineralizing agent composition according to claim 21, wherein the cleaning agent is sapindus peel extract, potassium coco-hydrolyzed oat protein, Candida bombicola / Glucanomyces brassicae ferment extract, sophorolipid, rapeseed sophorolipid, rhamnolipid, glycolipid, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha-olefin sulfonate, benzethonium chloride, cocoamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, cocoyl glucoside, cocoamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, maltodextrin glucoside, hydrogenated starch hydrolysate, or a combination of two or more thereof.

23. The hair demineralizing agent composition according to any one of claims 1-22, further comprising one or more pH regulators.

24. The hair demineralizing agent composition according to claim 23, wherein the one or more pH regulators are lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, L-arginine, or a combination of two or more thereof.

25. The hair demineralizing agent composition according to any one of claims 1-24, further comprising one or more solvents.

26. The hair demineralizing agent composition according to claim 25, wherein the one or more solvents include water, alcohol, isosorbide dimethyl ether, chlorotrifluoropropene, diol, triethyl citrate, or a combination of two or more thereof.

27. The hair demineralizing agent composition according to any one of claims 1-26, further comprising one or more anti-redeposition agents.

28. The hair demineralizing agent composition according to claim 27, wherein the one or more anti-redeposition agents include anionic functionalized biopolymers having chelating ability.

29. The hair demineralizing agent composition according to claim 27, wherein the one or more anti-redeposition agents are sodium carboxymethyl inulin, xanthan gum, hydroxyethyl cellulose, hydroxymethyl cellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethyl cellulose, amylopectin, scleroglucan, guar gum, gum arabic, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, magnesium sodium fluorosilicate, or a combination thereof.

30. The hair demineralizing agent composition according to any one of claims 1-29, further comprising one or more cosmetically or dermatologically acceptable excipients, wherein the one or more dermatologically acceptable excipients are fragrances, preservatives, or a combination thereof.

31. The hair demineralizing agent composition according to any one of claims 1-30, wherein the total concentration (% w / w) of the one or more demineralizing agents in the hair demineralizing agent is about 0.1% to about 15%.

32. The hair demineralizing agent composition according to claim 31, wherein the total concentration (w / w%) of the one or more demineralizing agents in the hair demineralizing agent is from about 0.1% to about 5%.

33. The hair demineralizing agent composition according to any one of claims 1 - 32, wherein the total concentration (% w / w) of the one or more antioxidants in the hair demineralizing agent composition is from about 0.1% to about 3%.

34. A method for demineralizing hair, the method comprising using the hair demineralizing agent composition according to any one of claims 1 - 33.

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