Preparation method of medicament for rosacea, acne rosacea and hormone face

Abstract

The invention discloses a preparation method of a medicament for rosacea, acne rosacea and hormone face, and belongs to the technical field of biological medicines. The invention aims to provide a medicament for safely, effectively and conveniently treating rosacea, acne rosacea and hormonal face, can relieve symptoms, and does not have the problems of relapse, more adverse reactions and the like. The medicament is prepared from the following raw materials in parts by weight: 10 to 20 parts of radix scutellariae, 10 to 20 parts of cortex phellodendri, 10 to 20 parts of radix sophorae flavescentis, 20 to 40 parts of fructus cnidii, 10 to 20 parts of fructus kochiae, 10 to 20 parts of cortex dictamni, 10 to 20 parts of honeysuckle flower, 10 to 20 parts of fructus forsythiae, 2 to 4 parts of radix angelicae sinensis and 8 to 16 parts of liquorice root. The medicament disclosed by the invention comprehensively solves a series of technical problems caused by skin barrier damage through the effects of supplementing intercellular lipid, resisting inflammation, relieving, promoting collagen synthesis, regulating skin immunity and the like, and an effective solution is provided for repairing the skin barrier and recovering skin health.

Description

Technical Field

[0001] The present invention belongs to the field of biological medicine technology. Specifically, it is a method for preparing a medicament for rosacea, rhinophyma, and hormone face. Background Art

[0002] Rosacea, also known as rhinophyma, is a chronic inflammatory skin disease mainly occurring in the central part of the face. Its pathogenesis is not yet clear and may be related to factors such as genetics and abnormal neurovascular regulation functions. It is mainly manifested as symptoms such as skin flushing, telangiectasia, papules, pustules, etc. It not only affects the appearance of patients but may also have a negative impact on the mental health of patients.

[0003] Hormone face is caused by the long-term improper use of glucocorticoid drugs or cosmetics containing hormones, etc., resulting in damage to the skin barrier and presenting a series of symptoms such as thinning of the skin, flushing, itching, dryness, desquamation, etc., bringing great pain to patients.

[0004] The patent document Mussel Adhesive Protein Product and Its Application in Inhibiting Skin Inflammation (Application No. CN202210132153.6) discloses the application of mussel adhesive protein or its preparation in inhibiting skin inflammation. Specifically, it discloses the application of mussel adhesive protein or its preparation in dermatitis, eczema, skin ulcers, burn surgery (including skin grafting), chilblains, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancer, folliculitis, urticaria, drug eruption, etc.; in sunburn, polymorphic light eruption, pathological alopecia (including hair transplantation), acne vulgaris, rosacea (i.e., rhinophyma), etc.; in the treatment of otitis externa. Skin inflammation is a skin-related disease and is one of the common and frequently-occurring diseases that seriously affect human health. When the skin barrier function declines, the skin will show internal skin inflammations such as roughness, flushing, itching, eczema, dryness, etc.

[0005] This technical solution has excellent effects in relieving erythema, swelling, edema, blisters, bullae caused by various skin inflammations, inhibiting the exudation of subcutaneous tissue fluid, relieving enlarged pores, and inhibiting itching and pain caused by inflammation. However, this technical solution is only for the application in the treatment of otitis externa.

[0006] Currently, there are many treatment methods for rosacea, rhinophyma, and hormone face, but the effects vary. Some traditional treatment methods, such as topical antibiotics, retinoid drugs, etc., can relieve symptoms to a certain extent, but there are problems such as easy recurrence and more adverse reactions. Physical methods such as laser treatment and photodynamic therapy are costly, have high technical requirements for operators, and may also have complications such as pigmentation and skin burns. Therefore, it is of great significance to develop a safe, effective, and convenient medicament for treating rosacea, rhinophyma, and hormone face. Summary of the Invention

[0007] The object of the present invention is to provide a method for preparing a medicament for rosacea, rhinophyma and hormone-dependent facial dermatitis. The prepared medicament can effectively improve the symptoms of rosacea, rhinophyma and hormone-dependent facial dermatitis, and has high safety and few side effects.

[0008] To achieve the above technical object, the technical solution adopted by the present invention is as follows:

[0009] The raw materials of the medicament include, by weight: 10-20 parts of Scutellaria baicalensis, 10-20 parts of Phellodendron amurense, 10-20 parts of Sophora flavescens, 20-40 parts of Fructus Cnidii, 10-20 parts of Kochia scoparia, 10-20 parts of Dictamnus dasycarpus, 10-20 parts of Lonicera japonica, 10-20 parts of Forsythia suspensa, 2-4 parts of Angelica sinensis, 8-16 parts of Glycyrrhiza uralensis.

[0010] The unique ratio provided by the present invention aims at the complex pathological mechanisms of rosacea, rhinophyma and hormone-dependent facial dermatitis, and synergistically takes effect from multiple aspects such as clearing heat and detoxifying, drying dampness and relieving itching, promoting blood circulation to remove blood stasis, and regulating various herbs. The present invention is based on in-depth research on the pathological mechanisms such as damaged skin barrier and inflammatory reaction of rosacea, rhinophyma and hormone-dependent facial dermatitis. By utilizing the characteristics of each medicinal material in the raw materials, such as using the anti-inflammatory effects of Scutellaria baicalensis and Phellodendron amurense to reduce the damage of inflammation to the skin barrier, and at the same time using Angelica sinensis to promote blood circulation to provide nutrition for barrier repair, this systematic integration and application of the action mechanisms of each raw material.

[0011] Specifically, the preparation method includes the following steps:

[0012] Step 1, pretreatment of raw materials: Wash Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Fructus Cnidii, Kochia scoparia, Dictamnus dasycarpus, Lonicera japonica, Forsythia suspensa, Angelica sinensis, and Glycyrrhiza uralensis respectively, remove impurities, cut into thin slices or small sections, and set aside;

[0013] Step 2, first extraction: Put the pretreated raw materials into an extraction tank, add 5-10 times the total weight of the raw materials of water, soak for 1-2 hours, then heat to boiling, keep boiling gently for 1-2 hours, filter, and collect the filtrate;

[0014] Step 3, second extraction: Add 3-5 times the total weight of the raw materials of water to the filter residue, heat to boiling again, keep boiling gently for 0.5-1 hour, filter, and collect the filtrate;

[0015] Step 4, combine the filtrates: Combine the filtrates obtained from the two extractions, put them into a concentration pot, and concentrate under reduced pressure to obtain a clear paste;

[0016] Step 5, drying and powder making: Put the clear paste into a spray dryer, and perform spray drying under the conditions of an inlet air temperature of 150-180°C and an outlet air temperature of 80-100°C to obtain a dry powder;

[0017] Step 6: Preparation of the preparation. Add an appropriate amount of excipients to the dry powder. After mixing evenly, prepare tablets, capsules, granules or topical ointments as needed.

[0018] For the invention adopting the above technical solution, in the medicament, firstly, it has the efficacy of clearing heat and detoxifying. Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Lonicera japonica and Forsythia suspensa have the efficacy of clearing heat and detoxifying, and can effectively reduce skin inflammatory reactions, relieve symptoms such as redness, papules and pustules of rosacea, rhinophyma and hormone face.

[0019] Secondly, it has the efficacy of drying dampness and relieving itching. Cnidium monnieri, Kochia scoparia and Dictamnus dasycarpus have the effect of drying dampness and relieving itching, can improve symptoms such as skin itching and desquamation, and reduce the discomfort of patients.

[0020] Thirdly, it has the efficacy of coordinating the properties of various drugs. Glycyrrhiza uralensis has the effect of coordinating the properties of various drugs, can relieve the toxicity and side effects of other drugs, and at the same time enhance the overall efficacy of the medicament.

[0021] Fourthly, it has the efficacy of metabolism. Angelica sinensis contains a variety of active ingredients, these ingredients can stimulate the metabolism of skin cells, enhance the activity of cells, and promote the increase in the production of intercellular lipids.

[0022] Fifthly, this medicament uses natural Chinese herbal medicines as raw materials, through scientific extraction and preparation processes, does not add harmful substances such as hormones and antibiotics, has high safety, and is not easy to produce drug resistance and dependence after long-term use.

[0023] Further defined, in the drying and powder making process, in step S1: transfer of the clear paste. Transfer the clear paste with a relative density of 1.10 - 1.20 obtained by vacuum concentration to a clean and sterile container. The temperature of the clear paste should be cooled to room temperature to avoid affecting the spray drying effect and the stability of active ingredients due to too high temperature. At the same time, ensure that there is no caking or precipitation in the clear paste, and filtration can be carried out if necessary to ensure the smoothness of the subsequent spraying process.

[0024] Step S2: feeding of the clear paste. Slowly transport the prepared clear paste to the nozzle of the spray dryer through a peristaltic pump. The feeding speed is controlled within the range that can make the nozzle spray evenly and the droplets in the drying tower can be fully dried, and the feeding speed is set at 2000 - 3000 mL / min.

[0025] Step S3: air supply of the clear paste. The inlet air temperature is set at 150 - 180 °C. The inlet air temperature can provide sufficient heat to quickly evaporate the moisture of the droplets. However, too high temperature may cause loss of heat-sensitive components, so it needs to be strictly controlled. The outlet air temperature is set at 80 - 100 °C. This temperature range not only ensures the full drying of the droplets, but also avoids the deterioration of the dry powder due to too high temperature. By adjusting the heating power of the hot air system and the air volume of the induced draft fan, maintain the inlet air and outlet air temperatures within the set range.

[0026] Step S4: Forming dry powder particles. The clear extract is formed into tiny droplets by high-speed rotation or high-pressure spraying at the nozzle. The droplets come into full contact with hot air and quickly evaporate water. During the process of the droplets falling in the drying tower, water is continuously lost and dry powder particles are gradually formed. In this process, it is necessary to closely observe the spraying state and material flow in the drying tower to ensure the uniformity and stability of the drying process.

[0027] Step S5: Collecting dry powder particles. The dried dry powder particles enter the cyclone separator with the airflow. Most of the dry powder is separated by centrifugal force and collected in the lower collecting container here. A small amount of unseparated fine powder is further collected by the bag filter to improve the recovery rate of the dry powder.

[0028] Step S6: Testing the dry powder. Quality testing is carried out on the collected dry powder, including indicators such as moisture content, particle size distribution, appearance color, etc. The moisture content should be controlled at a low level, generally not exceeding 5%, to ensure the stability of the dry powder. The particle size distribution needs to meet the product requirements and is detected by equipment such as a laser particle size analyzer to ensure that the dry powder has a suitable particle size, which is beneficial for subsequent formulation molding. The appearance color should be uniform, without obvious color difference or foreign matter. If the test results do not meet the requirements, it is necessary to adjust the spray drying conditions and prepare again.

[0029] Compared with the prior art, the skin barrier is like a protective cover of the skin. It is composed of sebum film, keratin in the stratum corneum, intercellular lipids, etc., and plays important roles such as maintaining skin moisture, preventing the invasion of external harmful substances, and regulating skin immunity. When the skin barrier is damaged, the skin will become sensitive and fragile, showing a series of problems such as dryness, peeling, flushing, itching, and stinging, seriously affecting the health and beauty of the skin. The present invention has a significant effect on repairing and improving the damaged skin barrier, effectively solving many technical problems caused by the damaged skin barrier.

[0030] This medicament comprehensively solves a series of technical problems brought about by the damaged skin barrier through multiple functions such as supplementing intercellular lipids, anti-inflammatory and soothing, promoting collagen synthesis, and regulating skin immunity, providing an effective solution for the repair of the skin barrier and the restoration of skin health. Whether for patients with rosacea, rhinophyma, or hormone face, their damaged skin barriers can be gradually repaired under the action of this medicament, enabling the skin to restore normal physiological functions and appearance states. Brief Description of the Drawings

[0031] The present invention can be further illustrated by the non-limiting embodiments given in the drawings;

[0032] Figure 1 It is a schematic process flow diagram of the preparation method of the medicament of the present invention;

[0033] Figure 2Schematic diagram of the drying and powder-making method for the medicament of the present invention;

[0034] Figure 3 Quality inspection indicators for the dry powder in the medicament preparation method of the present invention; Detailed implementation manners

[0035] In order to enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be further described below in conjunction with the drawings and embodiments.

[0036] As Figure 1 , Figure 2 , Figure 3 shown, a preparation method for a medicament for rosacea, rhinophyma and hormone face, the raw materials of the medicament include, by weight: 10-20 parts of Scutellaria baicalensis, 10-20 parts of Phellodendron amurense, 10-20 parts of Sophora flavescens, 20-40 parts of Fructus Cnidii, 10-20 parts of Kochia scoparia, 10-20 parts of Dictamnus dasycarpus, 10-20 parts of Lonicera japonica, 10-20 parts of Forsythia suspensa, 2-4 parts of Angelica sinensis, 8-16 parts of Glycyrrhiza uralensis.

[0037] The preparation method includes the following steps: Step 1, raw material pretreatment, wash Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Fructus Cnidii, Kochia scoparia, Dictamnus dasycarpus, Lonicera japonica, Forsythia suspensa, Angelica sinensis, and Glycyrrhiza uralensis respectively, remove impurities, cut into thin slices or small sections, and set aside; Step 2, first extraction, put the pretreated raw materials into an extraction tank, add 5-10 times the total weight of the raw materials of water, soak for 1-2 hours, then heat to boiling, keep boiling gently for 1-2 hours, filter, and collect the filtrate; Step 3, second extraction, add 3-5 times the total weight of the raw materials of water to the filter residue, heat to boiling again, keep boiling gently for 0.5-1 hour, filter, and collect the filtrate; Step 4, combine the filtrates, combine the filtrates obtained from the two extractions, put them into a concentration pot, and concentrate under reduced pressure to a clear paste; Step 5, drying and powder-making, put the clear paste into a spray dryer, and carry out spray drying under the conditions of an inlet air temperature of 150-180°C and an outlet air temperature of 80-100°C to obtain dry powder; Step 6, preparation forming, add appropriate excipients to the dry powder, mix evenly, and make different dosage forms such as tablets, capsules, granules or topical ointments as needed.

[0038] Specifically, in Step 5, drying and powder-making, it specifically includes, S1 clear paste transfer step, transfer the clear paste with a relative density of 1.10-1.20 obtained by concentration under reduced pressure to a clean and sterile container. The temperature of the clear paste should be cooled to room temperature to avoid affecting the spray drying effect and the stability of the active ingredients due to too high temperature. At the same time, ensure that the clear paste has no caking or precipitation phenomenon, and filter if necessary to ensure the smoothness of the subsequent spraying process.

[0039] S2 Clear extract feeding step: Slowly transport the prepared clear extract to the nozzle of the spray dryer through a peristaltic pump. The feeding speed is controlled within the range that can make the nozzle spray evenly and the droplets in the drying tower can be fully dried, and the feeding speed is set at 2000 - 3000 mL / min.

[0040] S3 Clear extract air supply step: The inlet air temperature is set at 150 - 180 °C. A higher inlet air temperature can provide sufficient heat to quickly evaporate the moisture of the droplets. However, too high a temperature may cause loss of heat-sensitive components, so it needs to be strictly controlled. The outlet air temperature is set at 80 - 100 °C. This temperature range not only ensures that the droplets are fully dried but also prevents the dry powder from deteriorating due to excessive temperature. By adjusting the heating power of the hot air system and the air volume of the induced draft fan, maintain the inlet and outlet air temperatures within the set range.

[0041] S4 Dry powder particle formation step: The clear extract is formed into tiny droplets by high-speed rotation or high-pressure spraying at the nozzle. The droplets are in full contact with the hot air and quickly evaporate moisture. During the process of the droplets falling in the drying tower, the moisture is continuously lost and gradually forms dry powder particles. During this process, closely observe the spraying state and material flow in the drying tower to ensure that the drying process is uniform and stable.

[0042] S5 Dry powder particle collection step: The dried dry powder particles enter the cyclone separator with the airflow. Most of the dry powder is separated by centrifugal force here and collected in the collection container at the lower part. A small amount of fine powder that is not separated is further collected by a bag filter to improve the recovery rate of the dry powder.

[0043] S6 Dry powder detection step: Conduct quality detection on the collected dry powder, including moisture content, particle size distribution, and appearance color index.

[0044] From Figure 3 It can be seen from the dry powder quality detection indicators that the dry powder particles prepared by this preparation process have a moisture content ≤ 4.0%. A lower moisture content helps to improve the stability of the dry powder, reduce the risk of microbial growth, and is beneficial for long-term preservation. The particle size distribution is D90: 30 - 50 μm, ensuring that the dry powder particle size is more suitable for subsequent preparation into various dosage forms and is beneficial for skin absorption. The appearance color is uniform, light brown, without obvious color difference and foreign matter, which is convenient for visually judging the product consistency.

[0045] Specifically, the weight ratio of Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Dictamnus dasycarpus, Lonicera japonica, Forsythia suspensa, Angelica sinensis, and Glycyrrhiza uralensis is 1:1:1:2:1:1:1:1:0.2:0.8.

[0046] More specifically, the soaking time in step two is 1.5 hours, and the decocting time is 1.5 hours.

[0047] In Step 3, the amount of water added is 4 times the total weight of the raw materials, and the decocting time is 0.8 hours.

[0048] In Step 4, the temperature for vacuum concentration is 70 °C, and the relative density of the clear extract after concentration is 1.15.

[0049] In Step 5, the inlet air temperature is 160 °C, and the outlet air temperature is 90 °C.

[0050] In a specific scheme, when preparing tablets, the excipients include sodium carboxymethylcellulose and magnesium stearate.

[0051] When preparing capsules, the excipients include hydroxypropyl methylcellulose.

[0052] When preparing topical ointments, the excipients include petrolatum and lanolin.

[0053] Example 1: Preparation of tablets

[0054] Raw material preparation: Weigh 15 parts of Scutellaria baicalensis, 15 parts of Phellodendron amurense, 15 parts of Sophora flavescens, 30 parts of Fructus Cnidii, 15 parts of Kochia scoparia, 15 parts of Dictamnus dasycarpus, 15 parts of Lonicera japonica, 15 parts of Forsythia suspensa, 3 parts of Angelica sinensis, and 12 parts of Glycyrrhiza uralensis.

[0055] Preparation steps:

[0056] Raw material pretreatment: Wash and cut each raw material according to the above method.

[0057] First extraction: Put the raw materials into an extraction tank, add 8 times the total weight of the raw materials of water, soak for 1.5 hours, heat to boiling and then decoct at a gentle boil for 1.5 hours, and filter to obtain the filtrate.

[0058] Second extraction: Add 4 times the total weight of the raw materials of water to the filter residue, decoct at a gentle boil for 0.8 hours after boiling, and filter to obtain the filtrate.

[0059] Combine the filtrates: Combine the two filtrates and concentrate them under reduced pressure at 70 °C to a clear extract with a relative density of 1.15.

[0060] Drying and powder making: Spray-dry the clear extract under the conditions of an inlet air temperature of 160 °C and an outlet air temperature of 90 °C to obtain dry powder.

[0061] Forming the preparation: Add an appropriate amount of sodium carboxymethylcellulose and magnesium stearate to the dry powder, mix evenly and press into tablets. Among them, the content of the active ingredient of Fructus Cnidii after making tablets is ≥ 20%.

[0062] Example 2: Preparation of capsules

[0063] Raw material preparation: Weigh 10 parts of Scutellaria baicalensis, 10 parts of Phellodendron amurense, 10 parts of Sophora flavescens, 20 parts of Fructus Cnidii, 10 parts of Kochia scoparia, 10 parts of Dictamnus dasycarpus, 10 parts of Lonicera japonica, 10 parts of Forsythia suspensa, 2 parts of Angelica sinensis, and 8 parts of Glycyrrhiza uralensis.

[0064] Preparation steps:

[0065] Raw material pretreatment: The same as Example 1.

[0066] First extraction: Add 5 times the total weight of the raw materials of water, soak for 1 hour, simmer for 1 hour after boiling, and filter.

[0067] Second extraction: Add 3 times the total weight of the raw materials of water, simmer for 0.5 hour after boiling, and filter.

[0068] Combine the filtrates: Concentrate under reduced pressure at 60 °C to a clear extract with a relative density of 1.10.

[0069] Drying and powder making: Spray dry at an inlet air temperature of 150 °C and an outlet air temperature of 80 °C to obtain dry powder.

[0070] Forming the preparation: Add an appropriate amount of hydroxypropyl methylcellulose to the dry powder and fill it into capsules to make capsule preparations. Among them, the content of the active ingredient of Cnidium monnieri in the tablets is ≥ 20%.

[0071] Example 3: Preparation of an external ointment

[0072] Raw material preparation: Weigh 20 parts of Scutellaria baicalensis, 20 parts of Phellodendron amurense, 20 parts of Sophora flavescens, 40 parts of Cnidium monnieri, 20 parts of Kochia scoparia, 20 parts of Dictamnus dasycarpus, 20 parts of Lonicera japonica, 20 parts of Forsythia suspensa, 4 parts of Angelica sinensis, and 16 parts of Glycyrrhiza uralensis.

[0073] Preparation steps:

[0074] Raw material pretreatment: The same as Example 1.

[0075] First extraction: Add 10 times the total weight of the raw materials of water, soak for 2 hours, simmer for 2 hours after boiling, and filter.

[0076] Second extraction: Add 5 times the total weight of the raw materials of water, simmer for 1 hour after boiling, and filter.

[0077] Combine the filtrates: Concentrate under reduced pressure at 80 °C to a clear extract with a relative density of 1.20.

[0078] Drying and powder making: Spray dry at an inlet air temperature of 180 °C and an outlet air temperature of 100 °C to obtain dry powder.

[0079] Forming the preparation: Add appropriate amounts of vaseline and lanolin excipients to the dry powder to make an external ointment. Among them, the content of the active ingredient of Cnidium monnieri in the tablets is ≥ 20%.

[0080] The present invention has the following effects

[0081] First, supplement the intercellular lipids and repair the skin structure.

[0082] The skin barrier of patients with rosacea and acne rosacea is often damaged due to repeated inflammation, while hormone face is caused by the destruction of the barrier structure due to long-term hormone use. Multiple natural plant ingredients in this medicine play a key role. For example, Dictamnus dasycarpus Turcz. contains a variety of active substances, which can promote the proliferation and differentiation of keratinocytes, help repair the damaged stratum corneum, and restore its normal arrangement and function. As an important part of the skin barrier, the repair of the stratum corneum structure helps to enhance the skin's ability to block external irritants and microorganisms, and reduce the loss of moisture through the epidermis. The active ingredients in Kochia scoparia (L.) Schrad. and Fructus Cnidii can participate in the synthesis and regulation of intercellular lipids. Intercellular lipids are like glue, filling between keratinocytes and maintaining the tightness of the skin barrier. By promoting the balance of intercellular lipids, the medicine further strengthens the skin barrier structure, enables the skin to restore normal barrier function, effectively relieves the sensitive state of the skin of patients with rosacea, acne rosacea and hormone face, and reduces the discomfort caused by external stimuli.

[0083] Second, anti-inflammatory and soothing, reducing inflammatory damage.

[0084] Inflammation is a common symptom of rosacea, acne rosacea and hormone face, and is also an important factor leading to skin barrier damage. Inflammatory reactions release a variety of inflammatory mediators, which not only cause symptoms such as skin redness, pain and itching, but also interfere with the normal metabolism and repair process of the skin barrier. Ingredients such as Scutellaria baicalensis Georgi, Phellodendron amurense Rupr., Lonicera japonica Thunb. and Forsythia suspensa (Thunb.) Vahl in this medicine have strong anti-inflammatory abilities. Baicalein in Scutellaria baicalensis Georgi can inhibit the activation of inflammatory signaling pathways and reduce the release of inflammatory factors such as interleukin and tumor necrosis factor, thus reducing skin inflammatory reactions. Phellodendron amurense Rupr. also has anti-inflammatory and antibacterial effects, can inhibit the reproduction of harmful microorganisms on the skin surface, and reduce the risk of inflammation caused by microbial infection. By effectively reducing inflammation, the medicine prevents further damage to the skin barrier by inflammation, creating favorable conditions for the self-repair of the skin barrier. At the same time, the relief of inflammation can also reduce the discomfort symptoms of patients, such as the subsidence of redness and the relief of itching, improving the quality of life of patients.

[0085] Third, promoting collagen synthesis and enhancing skin toughness.

[0086] The repair of the skin barrier requires an adequate supply of nutrients, while the skin microcirculation of patients with rosacea, acne rosacea and hormone face often has obstacles, affecting the transport of nutrients and the excretion of metabolic wastes. Angelica sinensis (Oliv.) Diels in this medicine plays a role in promoting blood circulation. The active ingredients in Angelica sinensis (Oliv.) Diels can not only promote blood circulation, but also have certain antioxidant effects, can scavenge free radicals in the skin, reduce the damage of free radicals to skin cells, and further protect the skin barrier. By improving skin microcirculation, the medicine provides an adequate material basis for the repair of the skin barrier, accelerates the repair process of the damaged barrier, and enables the skin to recover to a healthy state faster.

[0087] Fourth, regulate skin immunity and restore normal immune function.

[0088] After the skin barrier is damaged, the immune function of the skin is prone to disorder, leading to abnormal immune responses, which are relatively common in patients with rosacea, rhinophyma, and hormone-dependent dermatitis. Abnormal immune responses can trigger the immune system to attack its own skin tissues, further damaging the skin barrier. Licorice in this medicament has the function of regulating immunity, and its main component, glycyrrhizin, can regulate the activity of immune cells and balance immune responses. Glycyrrhizin can inhibit over-activated immune cells and reduce the production of antibodies such as immunoglobulin E, thereby reducing the occurrence probability of allergic reactions. At the same time, it can also enhance the immune defense ability of the skin and improve the skin's resistance to pathogens. By regulating skin immunity, the medicament prevents secondary damage to the skin barrier caused by abnormal immune responses, maintains the stability of the skin internal environment, and provides a good immune environment for the continuous repair and consolidation of the skin barrier.

[0089] The above has introduced in detail a preparation method of a medicament for rosacea, rhinophyma, and hormone-dependent dermatitis provided by the present invention. The description of specific embodiments is only used to help understand the method of the present invention and its core idea. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

Claims

1. A preparation method of a medicament for rosacea, rhinophyma and hormone face, characterized in that The raw materials of the medicament include, by weight: 10 - 20 parts of Scutellaria baicalensis, 10 - 20 parts of Phellodendron amurense, 10 - 20 parts of Sophora flavescens, 20 - 40 parts of Cnidium monnieri, 10 - 20 parts of Kochia scoparia, 10 - 20 parts of Dictamnus dasycarpus, 10 - 20 parts of Lonicera japonica, 10 - 20 parts of Forsythia suspensa, 2 - 4 parts of Angelica sinensis, and 8 - 16 parts of Glycyrrhiza uralensis.

2. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 1, characterized in that, The preparation method includes the following steps: Step 1, raw material pretreatment: Wash Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Dictamnus dasycarpus, Lonicera japonica, Forsythia suspensa, Angelica sinensis, and Glycyrrhiza uralensis respectively, remove impurities, cut into thin slices or small sections, and set aside. Step 2, first extraction: Put the pretreated raw materials into an extraction tank, add 5 - 10 times the total weight of the raw materials of water, soak for 1 - 2 hours, then heat to boiling, keep it boiling gently for 1 - 2 hours, filter, and collect the filtrate. Step 3, second extraction: Add 3 - 5 times the total weight of the raw materials of water to the filter residue, heat to boiling again, keep it boiling gently for 0.5 - 1 hour, filter, and collect the filtrate. Step 4, combine the filtrates: Combine the filtrates obtained from the two extractions, put them into a concentration pot, and concentrate under reduced pressure to obtain a clear paste. Step 5, drying and powder making: Put the clear paste into a spray dryer, and carry out spray drying under the conditions of an inlet air temperature of 150 - 180 °C and an outlet air temperature of 80 - 100 °C to obtain dry powder. Step 6, preparation forming: Add appropriate excipients to the dry powder, mix evenly, and make tablets, capsules, granules or topical ointments as needed.

3. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 2, characterized in that: In the step 5 of drying and powder making, it specifically includes: S1 clear paste transfer step, transfer the clear paste with a relative density of 1.10 - 1.20 obtained by concentration under reduced pressure to a clean and sterile container, and the temperature of the clear paste should be cooled to room temperature to ensure that there is no caking or precipitation in the clear paste. S2 clear paste feeding step: Slowly transport the prepared clear paste to the nozzle of the spray dryer through a peristaltic pump, and control the feeding speed within the range that can make the nozzle spray evenly and the droplets in the drying tower can be fully dried. The feeding speed is set at 2000 - 3000 mL / min. S3 clear paste air supply step: Set the inlet air temperature at 150 - 180 °C. The inlet air temperature can provide sufficient heat to quickly evaporate the water in the droplets, and set the outlet air temperature at 80 - 100 °C. S4 dry powder particle formation step: The clear paste is sprayed under high pressure at the nozzle to form tiny droplets. The droplets are in full contact with the hot air and quickly evaporate water. During the falling process of the droplets in the drying tower, water is continuously lost, and dry powder particles are gradually formed. S5 dry powder particle collection step: The dried dry powder particles enter the cyclone separator with the air flow. Most of the dry powder is separated and collected in the lower collection container by the centrifugal force here, and a small amount of unseparated fine powder is further collected by a bag filter. S6 dry powder detection step: Conduct quality detection on the collected dry powder, including moisture content, particle size distribution, and appearance color index.

4. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 3, characterized in that: The weight ratio of Scutellaria baicalensis, Phellodendron amurense, Sophora flavescens, Cnidium monnieri, Kochia scoparia, Dictamnus dasycarpus, Lonicera japonica, Forsythia suspensa, Angelica sinensis, and Glycyrrhiza uralensis is 1:1:1:2:1:1:1:1:0.2:0.

8.

5. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 4, characterized in that: The soaking time described in Step 2 is 1.5 hours, and the decocting time is 1.5 hours.

6. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 5, characterized in that: The amount of water added described in Step 3 is 4 times the total weight of the raw materials, and the decocting time is 0.8 hours.

7. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 6, characterized in that: The temperature for vacuum concentration described in Step 4 is 70 °C, and the relative density of the clear extract after concentration is 1.

15.

8. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 7, characterized in that: The inlet air temperature described in Step 5 is 160 °C, and the outlet air temperature is 90 °C.

9. The preparation method of the medicament for rosacea, rhinophyma and hormone face according to claim 8, wherein: When made into tablets, the excipients include sodium carboxymethylcellulose and magnesium stearate; when made into capsules, the excipients include hydroxypropyl methylcellulose; when made into external ointments, the excipients include petrolatum and lanolin.

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