Drug-loaded microsphere preparation device

Abstract

The invention discloses a drug-loaded microsphere preparation device, and relates to the technical field of pharmaceutical preparations, the drug-loaded microsphere preparation device comprises an emulsification reaction container, a filtering centrifugal device is arranged on one side of the emulsification reaction container, a drying device is arranged on one side of the filtering centrifugal device, a stirring assembly is arranged in the emulsification reaction container, and the top of the stirring assembly is in transmission connection with a connecting assembly; a driving assembly is arranged below the emulsification reaction container, a supporting piece is arranged in the center of the bottom face of the emulsification reaction container, the driving assembly pushes the emulsification reaction container to shake around the supporting piece, meanwhile, the driving assembly is connected with a connecting assembly through a transmission shaft, and the connecting assembly drives the stirring assembly to rotate and reciprocates up and down at the same time. The stirring assembly rotates and reciprocates up and down under the combined action of the driving assembly and the connecting assembly, so that the emulsifying effect can be enhanced, the medicine and the polymer are mixed more uniformly, and the medicine carrying microspheres with uniform particle size and stable quality can be formed.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical preparations, and particularly to a device for preparing drug-loaded microspheres. Background Art

[0002] In recent years, with the rapid development of the pharmaceutical industry and the continuous development and improvement of pharmaceutical technologies and materials, sustained-release and controlled-release preparations, as a new type of pharmaceutical dosage form, can enhance the therapeutic effect of drugs and have great development and application prospects. Among them, drug-loaded microspheres have become a hot research direction in the development of sustained-release and controlled-release preparations due to their advantages such as reducing the dosing frequency, maintaining a stable blood drug concentration, and reducing toxic and side effects. A drug-loaded microsphere is a tiny drug delivery system that dissolves, disperses, adsorbs, or encapsulates drugs in a polymer skeleton material, which can control the drug release rate, improve the drug stability, and change the therapeutic effect of drugs.

[0003] When preparing microspheres, it is necessary to stir the emulsion. The existing preparation devices have insufficient stirring performance, slow efficiency, and do not have a shaking function, resulting in uneven particles in the later preparation. Therefore, there is an urgent need for a device for preparing drug-loaded microspheres to solve the problems existing in the above-mentioned prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a device for preparing drug-loaded microspheres to solve the problems existing in the prior art.

[0005] To achieve the above purpose, the present invention provides the following solution: The present invention provides a device for preparing drug-loaded microspheres, which includes an emulsification reaction container. A filtration and centrifugation device is arranged on one side of the emulsification reaction container, and a drying device is arranged on one side of the filtration and centrifugation device. A stirring component is arranged in the emulsification reaction container. The top of the stirring component is drivingly connected with a connecting component. A driving component is arranged below the emulsification reaction container. A support is arranged at the center of the bottom surface of the emulsification reaction container. The driving component pushes the emulsification reaction container to shake around the support. At the same time, the driving component is connected with the connecting component through a transmission shaft. The connecting component drives the stirring component to rotate while moving up and down reciprocally.

[0006] Preferably, the driving component includes a motor. The output shaft of the motor is fixedly connected with a connecting shaft. A pair of eccentric wheels are fixedly connected to the connecting shaft. A moving rod contacts the side wall of the eccentric wheel. The top of the moving rod intermittently contacts the bottom surface of the emulsification reaction container. A second bevel gear is fixedly connected to the connecting shaft. The second bevel gear meshes with a first bevel gear. The first bevel gear is fixedly connected with the transmission shaft.

[0007] Preferably, a fixed box is arranged outside the connecting shaft. The motor is fixedly connected with the inner wall of the fixed box. One end of the connecting shaft away from the motor is rotatably connected with the inner wall of the fixed box.

[0008] Preferably, a spring is sleeved outside the moving rod. A fixing plate is fixedly connected to the moving rod. One end of the spring is fixedly connected to the inner wall of the fixed box, and the other end of the spring is fixedly connected to the fixing plate.

[0009] Preferably, the connecting component includes a fourth bevel gear which meshes with a third bevel gear. The third bevel gear is fixedly connected to the top of the transmission shaft. A connecting rod is fixedly connected to the center of the fourth bevel gear. One end of the connecting rod away from the fourth bevel gear is fixedly connected to a disc. An eccentric column is fixedly connected to the side wall of the disc. An annular frame is sleeved outside the eccentric column. One side of the annular frame away from the disc is fixedly connected to a shaft sleeve, and the shaft sleeve is in transmission connection with the stirring component.

[0010] Preferably, a transmission box is arranged outside the connecting rod. Limiting plates are slidably connected to both sides of the annular frame. The limiting plates are fixedly connected to the inner bottom surface of the transmission box. Limiting blocks are symmetrically arranged on the connecting rod. The limiting blocks are rotatably connected to the connecting rod and are fixedly connected to the inner bottom surface of the transmission box.

[0011] Preferably, the stirring component includes a stirring shaft which passes through the shaft sleeve and is rotatably connected to the shaft sleeve. The bottom of the stirring shaft extends into the emulsification reaction container and is fixedly connected with stirring blades.

[0012] Preferably, a plurality of stirring rods are further arranged on the stirring shaft, and the stirring rods are arc-shaped.

[0013] Preferably, retaining rings are symmetrically and fixedly connected to the stirring shaft, and the shaft sleeve is located between the two retaining rings.

[0014] Preferably, the top of the stirring shaft extends into a sleeve. The top of the sleeve is fixedly connected to the inner top surface of the transmission box. A surrounding groove is formed in the inner wall of the sleeve. A convex block is fixedly connected to the side wall of the stirring shaft, and the convex block is adapted to the surrounding groove.

[0015] The present invention discloses the following technical effects: During use, first dissolve the polymer material in an organic solvent, and disperse or dissolve the drug in this solution to form a dispersion system or solution. Then transfer the dispersion system or solution to an emulsification reaction vessel filled with an outer aqueous phase solution of PVA, and form small droplets by emulsification in the aqueous phase. The organic solvent first diffuses into the aqueous phase and then volatilizes into the air phase. The internal solution is made more uniform by the stirring assembly, and the emulsion droplets begin to harden into spheres. After being processed by a filtration and centrifugation device and a drying device, microspheres can be obtained. The present invention integrates the functions of emulsification, filtration and centrifugation, and drying, realizes the continuous operation of the preparation of drug-loaded microspheres, and improves production efficiency; the stirring assembly in the emulsification reaction vessel rotates and reciprocates up and down under the combined action of the driving assembly and the connecting assembly, which can enhance the emulsification effect, make the drug and the polymer mix more uniformly, and is conducive to the formation of drug-loaded microspheres with uniform particle size and stable quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The drawings forming a part of this application are used to provide a further understanding of this application. The schematic embodiments of this application and their descriptions are used to explain this application and do not constitute an improper limitation to this application. In the drawings:

[0017] Figure 1 is a schematic structural diagram of the present invention;

[0018] Figure 2 is a schematic internal structure diagram of the fixed box of the present invention;

[0019] Figure 3 is a schematic internal structure diagram of the transmission box of the present invention;

[0020] Figure 4 is a side view of the disc of the present invention;

[0021] Figure 5 is a schematic internal structure diagram of the emulsification reaction vessel of the present invention;

[0022] Figure 6 is a sectional view of the sleeve of the present invention;

[0023] In the figure: 1. Emulsification reaction vessel; 2. Transmission box; 3. Transmission shaft; 4. Filtration and centrifugation device; 5. Drying device; 6. Fixed box; 7. Moving rod; 8. Stirring shaft; 9. Motor; 10. First bevel gear; 11. Second bevel gear; 12. Eccentric wheel; 13. Spring; 14. Fixed plate; 15. Connecting shaft; 16. Third bevel gear; 17. Fourth bevel gear; 18. Limit block; 19. Connecting rod; 20. Disc; 21. Sleeve; 22. Bush; 23. Retaining ring; 24. Ring frame; 25. Eccentric column; 26. Limit plate; 27. Stirring rod; 28. Stirring blade; 29. Protrusion; 30. Surrounding groove. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0024] The preparation of drug-loaded microspheres refers to combining drugs with polymer materials and fabricating a spherical drug delivery system with a particle size ranging from micrometers to nanometers through specific processes. The core lies in utilizing the sustained-release, controlled-release, or targeting properties of polymer materials to encapsulate or adsorb drugs inside or on the surface of the microspheres, achieving the sustained release of drugs, targeted delivery, or local treatment. The preparation process generally includes the following steps: Material selection: According to the properties of the drug and treatment requirements, select suitable polymer materials (such as PLGA, sodium alginate, gelatin, etc.) as carriers. Drug loading: Embed the drug into the microsphere structure through methods such as physical adsorption, chemical bonding, or emulsion solvent evaporation. Microsphere shaping: Adopt techniques such as the emulsion-solvent evaporation method, spray drying method, phase separation method, etc. to form spherical or quasi-spherical microparticles. Post-treatment: Improve the stability of the microspheres and the drug encapsulation efficiency through steps such as washing, drying, and curing.

[0025] The main uses of drug-loaded microspheres include: 1. Sustained and controlled drug release for long-term treatment: Achieve the sustained release of drugs through the degradation or diffusion control of polymer materials, reducing the frequency of drug administration. For example, leuprorelin microspheres are used in the treatment of prostate cancer and can achieve drug administration once a month. Stable blood drug concentration: Avoid fluctuations in drug concentration, improve the therapeutic effect, and reduce side effects. 2. Targeted delivery for cancer treatment: Through surface modification (such as antibodies, ligands), enable the microspheres to specifically recognize tumor cells and achieve precise treatment. For example, doxorubicin microspheres can target tumor tissues and reduce damage to normal tissues. Delivery to the inflammatory site: Direct anti-inflammatory drugs to the inflammatory site and increase the local drug concentration. 3. Local treatment and embolization therapy: Inject the microspheres into the tumor-feeding artery to block blood supply and release chemotherapy drugs, achieving the effect of "starving the tumor". For example, HepaSphere microspheres are used in interventional treatment of liver cancer. Tissue repair: Microspheres loaded with growth factors can promote bone defect repair or soft tissue regeneration. 4. Reduce drug side effects and systemic toxicity: Through targeted delivery or local release, reduce the distribution of drugs in non-target organs and lower systemic toxicity. Improve drug stability: Protect the drug from the influence of the in vivo environment and improve bioavailability. 5. Cross-field applications in gene therapy: Microspheres loaded with DNA or RNA can be used for gene delivery to achieve gene therapy. Vaccine delivery: Serve as a vaccine adjuvant or antigen carrier to enhance the immune response.

[0026] The preparation of drug-loaded microspheres forms a microsphere system with sustained-release, controlled-release, or targeting functions by combining drugs with polymer materials, and is widely used in fields such as cancer treatment, local treatment, and tissue repair. Its core advantages lie in improving drug efficacy, reducing side effects, and decreasing the frequency of drug administration, providing an important tool for personalized medicine.

[0027] Drug-loaded microsphere preparation devices can be classified into various types according to different preparation principles and technologies: 1. Emulsion evaporation method preparation device. Principle: The drug and polymer are dissolved in an organic solvent, and an oil-in-water (W / O) emulsion is formed through emulsification, and then the organic solvent is evaporated to form microspheres. Device features: Stirrer: Used to mix the drug, polymer, and organic solvent to form a uniform oil phase. Emulsifier: Such as a high-pressure homogenizer or ultrasonic emulsifier, used to form a stable emulsion. Volatilization device: Such as a rotary evaporator or spray dryer, used to remove the organic solvent. Applications: Widely used in the preparation of polymer microspheres such as PLGA and PLA. 2. Spray drying method preparation device. Principle: The solution or suspension of the drug and polymer is sprayed into a hot gas stream through a sprayer, and the solvent quickly evaporates to form microspheres. Device features: Sprayer: Such as an air-atomizing sprayer or pressure-type sprayer, used to atomize the liquid into tiny droplets. Drying tower: Provides a hot gas stream to evaporate the solvent in the droplets. Collector: Used to collect the dried microspheres. Applications: Suitable for drugs with good thermal stability, such as the microsphere preparation of proteins and polypeptides. 3. Phase separation method preparation device. Principle: By changing the solvent conditions (such as temperature, pH value, adding a non-solvent, etc.), the polymer precipitates from the solution and encapsulates the drug to form microspheres. Device features: Reaction kettle: Used to mix the drug, polymer, and solvent and control the reaction conditions. Stirrer: Ensures uniform mixing. Separator: Such as a centrifuge or filter, used to separate the microspheres and the solvent. Applications: Suitable for the microsphere preparation of various polymers and drugs. 4. Microfluidic method preparation device. Principle: Utilize a microfluidic chip to precisely control the fluid flow to form monodisperse droplets, and then form microspheres through solidification. Device features: Microfluidic chip: Has micron-sized channels for precisely controlling the fluid. Syringe pump: Used to drive the fluid flow. Solidification device: Such as an ultraviolet light curing device or thermal curing device, used to solidify the droplets. Applications: Can prepare microspheres with uniform and controllable particle sizes, suitable for high-precision drug delivery systems. 5. Membrane emulsification method preparation device. Principle: Utilize the pore size of the membrane to control the size of the emulsion droplets, form a uniform emulsion through membrane emulsification, and then evaporate the solvent to form microspheres. Device features: Membrane emulsifier: Has a microporous membrane for controlling the size of the emulsion droplets. Pressure pump: Used to drive the liquid through the membrane. Volatilization device: Such as a rotary evaporator, used to remove the solvent. Applications: Can prepare microspheres with uniform particle sizes and good dispersibility. 6. Supercritical fluid method preparation device. Principle: Utilize the solubility and diffusivity of supercritical fluids (such as CO2), dissolve the drug and polymer in it, and then precipitate the polymer by rapidly reducing the pressure to form microspheres. Device features: Supercritical fluid reactor: Used to control the temperature and pressure to form a supercritical fluid. Nozzle: Used to spray the solution of the drug and polymer into the supercritical fluid. Collector: Used to collect the microspheres. Applications: Suitable for the microsphere preparation of thermosensitive drugs and polymers. 7. Electrostatic spraying method preparation device. Principle: Utilize a high-voltage electrostatic field to make the solution or suspension of the drug and polymer form charged droplets, and the droplets fly and dry in the electric field to form microspheres.Device features: Electrostatic sprayer: It has a high-voltage power supply and a nozzle for forming charged droplets. Collector: It is used to collect the dried microspheres. Application: It can prepare microspheres with small particle size and good dispersibility, and is suitable for nano-scale drug delivery systems. 8. Automated preparation system, Principle: Integrate multiple preparation technologies into an automated system to achieve continuous and efficient preparation of microspheres. Device features: Automated control: Control the parameters of each step through PLC or computer. Modular design: Different modules can be replaced according to needs to achieve different preparation methods. On-line monitoring: Real-time monitor parameters such as the particle size and morphology of microspheres. Application: Suitable for large-scale industrial production.

[0028] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0029] To make the above objects, features, and advantages of the present invention more obvious and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0030] Refer to Figures 1-6 As shown, this embodiment provides a drug-loaded microsphere preparation device, which includes an emulsification reaction container 1. A filtration and centrifugation device 4 is arranged on one side of the emulsification reaction container 1, and a drying device 5 is arranged on one side of the filtration and centrifugation device 4. A stirring component is arranged in the emulsification reaction container 1. The top of the stirring component is connected by a transmission connection component. A driving component is arranged below the emulsification reaction container 1. A support member is arranged at the center of the bottom surface of the emulsification reaction container 1. The driving component pushes the emulsification reaction container 1 to shake around the support member. At the same time, the driving component is connected to the connection component through a transmission shaft 3. While the connection component drives the stirring component to rotate, it also moves up and down reciprocally.

[0031] In use, first dissolve the polymer material in an organic solvent, and disperse or dissolve the drug in the solution to form a dispersion system or solution. Then transfer the dispersion system or solution to the emulsification reaction vessel 1, which contains an outer aqueous phase solution of PVA. Emulsify to form small droplets in the aqueous phase. The organic solvent first diffuses into the aqueous phase and then volatilizes into the air phase. The internal solution is made more uniform by the stirring assembly, and the emulsion droplets begin to harden into spheres. After being processed by the filtration and centrifugation device 4 and the drying device 5, microspheres can be obtained. The present invention integrates the functions of emulsification, filtration, centrifugation, and drying, realizing continuous operation in the preparation of drug-loaded microspheres and improving production efficiency. The stirring assembly in the emulsification reaction vessel 1 rotates and reciprocates up and down under the combined action of the driving assembly and the connecting assembly, which can enhance the emulsification effect, make the drug and the polymer mix more uniformly, and is conducive to the formation of drug-loaded microspheres with uniform particle size and stable quality.

[0032] In a further optimized solution, the driving assembly includes a motor 9. The output shaft of the motor 9 is fixedly connected to a connecting shaft 15. A pair of eccentric wheels 12 are fixedly connected to the connecting shaft 15. The side wall of the eccentric wheel 12 contacts a moving rod 7. The top of the moving rod 7 intermittently contacts the bottom surface of the emulsification reaction vessel 1. A second bevel gear 11 is fixedly connected to the connecting shaft 15. The second bevel gear 11 meshes with a first bevel gear 10. The first bevel gear 10 is fixedly connected to a transmission shaft 3. The driving assembly adopts a structure in which the motor 9 drives the connecting shaft 15 and the eccentric wheels 12. Through the intermittent contact between the eccentric wheel 12 and the moving rod 7, the emulsification reaction vessel 1 is pushed to shake around the support, which helps the mixing and dispersion of the materials in the emulsification reaction vessel 1 and improves the emulsification efficiency. At the same time, the second bevel gear 11 on the connecting shaft 15 meshes with the first bevel gear 10, transmitting the power to the transmission shaft 3, realizing a clever design of power transmission and providing a power basis for the subsequent movement of the connecting assembly to drive the stirring assembly.

[0033] In a further optimized solution, a fixed box 6 is provided outside the connecting shaft 15. The motor 9 is fixedly connected to the inner wall of the fixed box 6. The end of the connecting shaft 15 away from the motor 9 is rotatably connected to the inner wall of the fixed box 6. The setting of the fixed box 6 plays a role in protecting and fixing the motor 9 and the connecting shaft 15, ensuring the stable operation of the driving assembly. The motor 9 is fixedly connected to the inner wall of the fixed box 6, and the end of the connecting shaft 15 away from the motor 9 is rotatably connected to the inner wall of the fixed box 6. This structure makes the rotation of the connecting shaft 15 smoother, reduces vibration and noise, and improves the reliability and service life of the device.

[0034] In a further optimized solution, a spring 13 is sleeved on the outer side of the moving rod 7, a fixing plate 14 is fixedly connected to the moving rod 7, one end of the spring 13 is fixedly connected to the inner wall of the fixing box 6, and the other end of the spring 13 is fixedly connected to the fixing plate 14. The setting of the spring 13 enables the moving rod 7 to be elastically reset under the push of the eccentric wheel 12, ensuring the intermittent contact effect between the moving rod 7 and the bottom surface of the emulsification reaction container 1, making the shaking of the emulsification reaction container 1 more stable and regular. The setting of the fixing plate 14 facilitates the installation and fixing of the spring 13, ensuring that the spring 13 can function normally.

[0035] Further optimization scheme, the connection assembly includes a fourth bevel gear 17, the fourth bevel gear 17 is meshed with the third bevel gear 16, the third bevel gear 16 is fixedly connected to the top of the transmission shaft 3, the center of the fourth bevel gear 17 is fixedly connected to a connecting rod 19, the end of the connecting rod 19 away from the fourth bevel gear 17 is fixedly connected to a disc 20, the side wall of the disc 20 is fixedly connected to an eccentric column 25, the outer side of the eccentric column 25 is sleeved with an annular frame 24, the side of the annular frame 24 away from the disc 20 is fixedly connected to a shaft sleeve 22, and the shaft sleeve 22 is transmission-connected to the stirring assembly. The connection assembly transmits the rotation of the transmission shaft 3 to the connecting rod 19 through the meshing of the third bevel gear 16 and the fourth bevel gear 17, thereby realizing the transmission and steering of power. The cooperation between the disc 20 and the eccentric column 25 on the connecting rod 19 and the annular frame 24 enables the annular frame 24 to drive the shaft sleeve 22 to move up and down. This design ingeniously converts the rotational motion of the transmission shaft 3 into the rotation and up and down reciprocating motion of the stirring assembly, further enhancing the stirring effect and facilitating the preparation of drug-loaded microspheres.

[0036] Further optimization scheme, a transmission box 2 is provided on the outside of the connecting rod 19, and limit plates 26 are slidably connected on both sides of the annular frame 24. The limit plates 26 are fixedly connected to the inner bottom surface of the transmission box 2. The limit blocks 18 are symmetrically arranged on the connecting rod 19. The limit blocks 18 are rotatably connected to the connecting rod 19, and the limit blocks 18 are fixedly connected to the inner bottom surface of the transmission box 2. The transmission box 2 provides installation and protection space for the connection assembly, making the operation of the connection assembly more stable. The setting of the limit plates 26 plays a role in limiting and guiding the annular frame 24, ensuring that the annular frame 24 can move back and forth up and down along a straight line. The rotational connection and fixed connection between the limit blocks 18 and the connecting rod 19 not only ensure the rotational freedom of the connecting rod 19, but also limit the axial movement of the connecting rod 19, thereby improving the stability and reliability of the connection assembly.

[0037] For a further optimized solution, the stirring assembly includes a stirring shaft 8. The stirring shaft 8 passes through the bushing 22 and is rotatably connected to the bushing 22. The bottom of the stirring shaft 8 extends into the emulsification reaction vessel 1 and is fixedly connected with a stirring blade 28. The stirring shaft 8 of the stirring assembly passes through the bushing 22 and is rotatably connected to the bushing 22, realizing the stable rotation of the stirring shaft 8. The stirring blade 28 at the bottom of the stirring shaft 8 can fully stir the materials in the emulsification reaction vessel 1, promoting the mixing of the drug and the polymer. The stirring shaft 8 extends into the emulsification reaction vessel 1, enabling the stirring action to directly act on the materials and improving the stirring efficiency.

[0038] For a further optimized solution, a number of stirring rods 27 are also arranged on the stirring shaft 8, and the stirring rods 27 are arc-shaped. The arc-shaped stirring rods 27 on the stirring shaft 8 increase the stirring area, can better stir the materials, and make the material mixing more uniform. The arc design can also reduce the shear force on the materials during stirring, avoid the damage of the drug and the polymer, and is beneficial to the formation of drug-loaded microspheres with good quality.

[0039] For a further optimized solution, retaining rings 23 are symmetrically and fixedly connected to the stirring shaft 8, and the bushing 22 is located between the two retaining rings 23. The retaining rings 23 on the stirring shaft 8 play a limiting role on the bushing 22, preventing the bushing 22 from axially moving on the stirring shaft 8 and ensuring the normal operation of the stirring assembly. At the same time, the retaining rings 23 can also disperse the force received by the bushing 22, reduce the wear of the bushing 22, and extend the service life of the bushing 22.

[0040] For a further optimized solution, the top of the stirring shaft 8 extends into the sleeve 21. The top of the sleeve 21 is fixedly connected to the inner top surface of the transmission box 2. A circumferential groove 30 is formed on the inner wall of the sleeve 21, and a convex block 29 is fixedly connected to the side wall of the stirring shaft 8. The convex block 29 is adapted to the circumferential groove 30. The circumferential groove 30 in the sleeve 21 is adapted to the convex block 29 on the side wall of the stirring shaft 8, playing a guiding and limiting role on the stirring shaft 8, enabling the stirring shaft 8 to maintain stable rotation during the up and down reciprocating movement. This design further improves the stability and reliability of the stirring assembly, ensuring the smooth progress of the preparation process of the drug-loaded microspheres.

[0041] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "longitudinal", "transverse", "up", "down", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0042] The embodiments described above are only descriptions of the preferred embodiments of the present invention, and do not limit the scope of the present invention. Without departing from the spirit of the present invention design, various deformations and improvements made by those of ordinary skill in the art to the technical solutions of the present invention should fall within the protection scope determined by the claims of the present invention.

Claims

1. A drug-loaded microsphere preparation device, characterized in that: It includes an emulsification reaction vessel (1), a filtration and centrifugation device (4) is arranged on one side of the emulsification reaction vessel (1), a drying device (5) is arranged on one side of the filtration and centrifugation device (4), a stirring assembly is arranged in the emulsification reaction vessel (1), a connection assembly is drivingly connected to the top of the stirring assembly, a driving assembly is arranged below the emulsification reaction vessel (1), a support member is arranged at the center of the bottom surface of the emulsification reaction vessel (1), the driving assembly pushes the emulsification reaction vessel (1) to shake around the support member, and at the same time, the driving assembly is connected to the connection assembly through a transmission shaft (3), and the connection assembly drives the stirring assembly to rotate and move up and down reciprocally while rotating.

2. The drug-loaded microsphere preparation device according to claim 1, characterized in that: The driving assembly includes a motor (9), an output shaft of the motor (9) is fixedly connected to a connection shaft (15), a pair of eccentric wheels (12) are fixedly connected to the connection shaft (15), a moving rod (7) is in contact with the side wall of the eccentric wheel (12), the top of the moving rod (7) is intermittently in contact with the bottom surface of the emulsification reaction vessel (1), a second bevel gear (11) is fixedly connected to the connection shaft (15), the second bevel gear (11) meshes with a first bevel gear (10), and the first bevel gear (10) is fixedly connected to the transmission shaft (3).

3. The drug-loaded microsphere preparation device according to claim 2, characterized in that: A fixed box (6) is arranged outside the connection shaft (15), the motor (9) is fixedly connected to the inner wall of the fixed box (6), and one end of the connection shaft (15) away from the motor (9) is rotatably connected to the inner wall of the fixed box (6).

4. The drug-loaded microsphere preparation device according to claim 3, wherein: A spring (13) is sleeved outside the moving rod (7), a fixing plate (14) is fixedly connected to the moving rod (7), one end of the spring (13) is fixedly connected to the inner wall of the fixed box (6), and the other end of the spring (13) is fixedly connected to the fixing plate (14).

5. The drug-loaded microsphere preparation device according to claim 1, characterized in that: The connection assembly includes a fourth bevel gear (17), the fourth bevel gear (17) meshes with a third bevel gear (16), the third bevel gear (16) is fixedly connected to the top of the transmission shaft (3), a connecting rod (19) is fixedly connected to the center of the fourth bevel gear (17), one end of the connecting rod (19) away from the fourth bevel gear (17) is fixedly connected to a disc (20), an eccentric column (25) is fixedly connected to the side wall of the disc (20), an annular frame (24) is sleeved outside the eccentric column (25), and a shaft sleeve (22) is fixedly connected to one side of the annular frame (24) away from the disc (20), and the shaft sleeve (22) is drivingly connected to the stirring assembly.

6. The drug-loaded microsphere preparation device according to claim 5, wherein: A transmission box (2) is arranged outside the connecting rod (19), limiting plates (26) are slidably connected to both sides of the annular frame (24), the limiting plates (26) are fixedly connected to the inner bottom surface of the transmission box (2), limiting blocks (18) are symmetrically arranged on the connecting rod (19), the limiting blocks (18) are rotatably connected to the connecting rod (19), and the limiting blocks (18) are fixedly connected to the inner bottom surface of the transmission box (2).

7. The drug-loaded microsphere preparation device according to claim 6, wherein: The stirring assembly includes a stirring shaft (8), the stirring shaft (8) passes through the bushing (22) and is rotatably connected to the bushing (22), and the bottom of the stirring shaft (8) extends into the emulsification reaction vessel (1) and is fixedly connected with a stirring blade (28).

8. The drug-loaded microsphere preparation device according to claim 7, wherein: A plurality of stirring rods (27) are further arranged on the stirring shaft (8), and the stirring rods (27) are arc-shaped.

9. The drug-loaded microsphere preparation device according to claim 7, wherein: Blocking rings (23) are symmetrically and fixedly connected to the stirring shaft (8), and the bushing (22) is located between the two blocking rings (23).

10. The drug-loaded microsphere preparation device according to claim 7, wherein: The top of the stirring shaft (8) extends into a sleeve (21), the top of the sleeve (21) is fixedly connected to the inner top surface of the transmission box (2), a surrounding groove (30) is formed in the inner wall of the sleeve (21), a convex block (29) is fixedly connected to the side wall of the stirring shaft (8), and the convex block (29) is adapted to the surrounding groove (30).

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