Application of tortoise shells in treatment of female sexual dysfunction

Abstract

The invention discloses application of tortoise shells in treatment of female sexual dysfunction, the tortoise shells are applied to women for the first time, especially to treatment of sexual dysfunction of climacteric women, and the treatment effect is remarkable; the composition is simple, the cost is low, and a new direction and more choices can be provided for improving and treating the female sexual dysfunction.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly to the application of tortoise shell in the treatment of female sexual dysfunction. Background Art

[0002] Female sexual dysfunction (FSD) refers to the disorder of one or several links in the process of female sexual intercourse, including lack of sexual desire, inability to arouse sexual desire, inability to reach orgasm, etc., or symptoms such as pain related to sexual intercourse. Female sexual dysfunction is prone to occur in female groups around menopause. The physical and mental troubles brought by female sexual dysfunction affect people's quality of life and even the harmony of the family. However, the current society pays little attention to female sexual dysfunction. At present, there are few effective drugs for the treatment of female sexual dysfunction. Among them, hormonal drugs have better effects, but also have greater side effects. Summary of the Invention

[0003] Based on the above background, the present invention provides the application of tortoise shell in the treatment of female sexual dysfunction, which is composed of tortoise shell as the effective component, and can effectively improve and treat the sexual dysfunction of women, especially menopausal women.

[0004] The technical solution provided by the present invention is as follows:

[0005] The application of tortoise shell in the preparation of drugs for the treatment of female sexual dysfunction.

[0006] Further, the characteristics of the female sexual dysfunction include at least one of the following:

[0007] ① Decreased sexual desire or complete lack of sexual desire;

[0008] ② Sexual arousal disorder and / or insufficient lubrication;

[0009] ③ Difficulty in achieving and maintaining lubrication;

[0010] ④ Difficulty in achieving orgasm, low orgasm intensity or lack of sexual pleasure;

[0011] ⑤ Sexual intercourse pain.

[0012] Further, the female is a menopausal woman.

[0013] Further, the menopausal woman is a perimenopausal woman.

[0014] Further, the effective component of the drug is the extract of tortoise shell.

[0015] Further, the drug can be made into a vaginal administration preparation by adding pharmaceutically acceptable adjuvants.

[0016] Specifically, solid preparations such as tablets, capsules, powders, granules, dripping pills, suppositories; or liquid preparations such as sols, suspensions, emulsions are all acceptable.

[0017] Based on the same inventive concept, the present invention also provides the use of tortoise shell in the preparation of products for enhancing female sexual arousal and / or enhancing sexual desire.

[0018] Furthermore, the product is a vaginal administration preparation.

[0019] Based on the same inventive concept, the present invention also provides a drug for treating female sexual dysfunction, which is made from raw materials in the following proportions by weight:

[0020] 70-85% of tortoise shell glue, 2-15% of microcrystalline cellulose, 5-15% of pregelatinized starch.

[0021] Furthermore, the drug is a vaginal administration capsule.

[0022] The beneficial effects achieved by the present invention are as follows:

[0023] The present invention first applies tortoise shell to treat female sexual dysfunction, especially for menopausal women, with significant treatment effects and no side effects; and has a simple composition and low cost. Therefore, the present invention can provide a new direction and more choices for improving and treating female sexual dysfunction. Detailed implementation manners

[0024] To make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0025] Example 1: A drug for treating female sexual dysfunction, which is made from raw materials in the following proportions by weight:

[0026] 82% of tortoise shell glue, 6% of microcrystalline cellulose, 12% of pregelatinized starch.

[0027] The tortoise shell glue in this example can be extracted with water or ethanol as a solvent and then concentrated into glue.

[0028] Specifically, when using water as a solvent, the preparation of the drug of the present invention includes the following steps:

[0029] 1) Take tortoise shell, cut and break it into appropriate-sized blocks or flakes;

[0030] 2) After adding water to the crushed turtle shell, the amount of water should be sufficient to submerge the turtle shell. Then, slowly boil it over medium-low heat for 30 - 45 minutes (when the water evaporates and decreases, add boiling water appropriately to supplement). After taking out the decoction, add water again to the turtle shell and slowly boil it over medium-low heat for 30 - 45 minutes. After taking out the decoction again, add water again to the turtle shell and slowly boil it over medium-low heat for 30 - 45 minutes, and then take out the decoction again;

[0031] 3) Combine the three decoctions, filter, and keep the filtrate;

[0032] 4) Heat and concentrate the filtrate to collect the glue until the glue solution can form a flag (that is, scoop up the glue solution with a spoon, and the glue solution can drip in a flag shape along the edge of the spoon). After stopping heating, wait until the temperature drops to 60 °C, add microcrystalline cellulose while stirring. After complete solidification, conduct vacuum drying, pulverize, sieve through 50 - 80 meshes, and then mix it with pregelatinized starch;

[0033] 5) Fill the above medicine into capsules at 0.5 g per capsule, and the capsules are made of gelatin.

[0034] Example 2:

[0035] Thirty-six patients with female sexual dysfunction evaluated as having a score of < 25 on the Female Sexual Function Index (FSFI) scale, aged 42 - 57 years, 5 of whom had been menopausal for more than 1 year, and 26 patients had been judged by doctors to be in the perimenopausal period.

[0036] The FSFI scale is a multi-dimensional standardized tool widely used to evaluate female sexual dysfunction (FSD), covering six dimensions: libido, sexual arousal, vaginal lubrication, orgasm, satisfaction, and dyspareunia. The total score range of the scale is 0 to 36 points, and the higher the score, the better the sexual function.

[0037] Exclusion criteria: ① Pregnancy; ② Urinary and reproductive system infections, malignant tumors, within 1 month after gynecological surgery, severe organic diseases of the heart, liver, and kidneys, neurological diseases, those with intellectual and mental disorders; ③ Sexual dysfunction caused by gynecological inflammation, organic lesions, and endocrine system diseases; ④ Sexual dysfunction caused by psychological factors; ⑤ Caused by male factors; ⑥ Those without a fixed sexual partner; ⑦ Taking drugs that affect or are suspected of affecting sexual function (such as antihypertensive drugs, sedatives).

[0038] Treat the enrolled patients with Example 1. During treatment, insert one capsule into the vagina every night before going to bed, as close to the cervical os as possible. After continuous treatment for 16 weeks, conduct the FSFI scale evaluation again.

[0039] Efficacy criteria:

[0040] Marked effect: FSFI scale score > 25;

[0041] Effective: The increase in the FSFI scale score is 10 points or more (including 10 points), but ≤ 25;

[0042] Ineffective: The FSFI scale score has not changed or decreased, or the increase in the score is less than 10 points.

[0043] Therapeutic effect results: Among the above patients, 4 were ineffective, 12 were effective, and 20 were markedly effective. The effective rate was 88.9%.

[0044] Comparison of sexual function indices (average values) of the above patients before and after intervention is shown in the following table:

[0045]

[0046] The present invention can also be applied to improve the sexual desire of normal women and enhance sexual pleasure. For example, before sexual intercourse, insert a capsule into the vagina as close to the cervical os as possible. After 20 - 30 minutes, it can promote excitement, facilitate reaching orgasm, and enhance sexual pleasure.

[0047] The above describes the present invention and its implementation manners. Such description is not restrictive. What is shown in the embodiments is only one of the implementation manners of the present invention, and the actual structure is not limited thereto. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the gist of the present invention, design similar structural manners and embodiments to this technical solution without creative efforts, they shall fall within the protection scope of the present invention.

Claims

1. Use of tortoise shell in the preparation of drugs for treating female sexual dysfunction.

2. The application according to claim 1, wherein The characteristics of the female sexual dysfunction include at least one of the following: ① Decreased libido or complete lack of libido; ② Sexual arousal disorder and / or insufficient lubrication; ③ Difficulty in achieving and maintaining lubrication; ④ Difficulty in achieving orgasm, low orgasm intensity or lack of sexual pleasure; ⑤ Dyspareunia.

3. The application according to claim 2, wherein The female is a menopausal woman.

4. The application according to claim 3, wherein The menopausal woman is a perimenopausal woman.

5. The application according to claim 1, wherein The effective ingredient of the drug is the extract of tortoise shell.

6. The application according to claim 1, wherein The drug can be made into a vaginal administration preparation by adding pharmaceutically acceptable adjuvants.

7. Use of tortoise shell in the preparation of products for enhancing female sexual arousal and / or enhancing sexual desire.

8. The application according to claim 7, wherein The product is a vaginal administration preparation.

9. A drug for treating female sexual dysfunction, characterized in that, By weight, it is made from raw materials in the following proportions: Colla carapacis et plastri testudinis 70 - 85%, microcrystalline cellulose 2 - 15%, pregelatinized starch 5 - 15%.

10. A drug for treating female sexual dysfunction according to claim 9, characterized in that, The drug is a vaginal administration preparation.

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