Control method and device of ion chromatography three-column suppressor and computer readable storage medium

Abstract

The invention provides a control method of an ion chromatography three-column suppressor. The control method comprises the following steps: (1) obtaining the running time P1 of the three-column suppressor in an equilibrium state; (2) judging whether the balance state operation time P1 reaches the balance column switching time T1 or not, not switching the position of the suppressor column under the condition that P1 is less than T1, and switching the position of the suppressor column under the condition that P1 is equal to T1; (3) judging whether a sample introduction signal is received or not, and repeating the step (2) when the sample introduction signal is not received; turning to the step (4) when a sample introduction signal is received; (4) sample injection detection is started, and the operation time P2 of the three-column suppressor in the sample injection state is obtained; (5) judging whether the sample injection state operation time P2 reaches the sample injection column cutting time T2 or not, and under the condition that P2 is less than T2, not switching the suppressor column body; and under the condition that P2 is larger than or equal to T2, the position of the suppressor cylinder is switched, and the step (3) is repeated. The invention further discloses a control device of the ion chromatography three-column suppressor and a computer readable storage medium.

Description

Technical Field

[0001] The present invention belongs to the technical field of ion chromatography suppressors, and particularly relates to a control method and device for an ion chromatography three-column suppressor and a computer-readable storage medium. Background Art

[0002] Currently, in an ion chromatograph, a suppressor is a crucial component, and its main function is to significantly improve the detection sensitivity by reducing the background conductivity. In ion chromatography analysis, the eluent itself is usually a strong electrolyte with a high conductivity, which will mask the signal of the target ion and lead to a decrease in detection sensitivity. The suppressor converts the background ions in the eluent into substances with low conductivity through chemical or electrochemical reactions, thereby reducing the background conductivity and enhancing the detection signal. Among them, the suppressor includes two working states: the equilibrium state and the injection state. After the suppression column in the suppressor can be regenerated through the regeneration process after working for a period of time, it can continue the next operation. The regeneration process mainly includes two steps: water washing and acid washing. In the prior art, the regeneration process of the suppression column in the equilibrium state and the injection state is manually controlled, and there may be problems such as repeated use of the suppression column, untimely regeneration, or incomplete regeneration.

[0003] In order to solve the above technical problems, the present invention designs a control method and device for an ion chromatography three-column suppressor and a computer-readable storage medium. Summary of the Invention

[0004] The present invention provides a control method and device for an ion chromatography three-column suppressor and a computer-readable storage medium, aiming to solve the problems of untimely regeneration or incomplete regeneration of the suppression column of the ion chromatography column suppressor.

[0005] To achieve the above object, the present invention provides the following technical solution: A control method for an ion chromatography three-column suppressor includes the following steps: (1) Obtain the running time P1 of the three-column suppressor in the equilibrium state; (2) Judge whether the equilibrium state running time P1 reaches the equilibrium column switching time T1. When P1 < T1, do not switch the column position of the suppressor. When P1 = T1, switch the column position of the suppressor; (3) Judge whether an injection signal is received. When the injection signal is not received, repeat step (2); when the injection signal is received, transfer to step (4); (4) Start the injection detection, and obtain the running time P2 of the three-column suppressor in the injection state; (5) Judge whether the injection state running time P2 reaches the injection column switching time T2. When P2 < T2, do not switch the column of the suppressor; when P2 ≥ T2, switch the column position of the suppressor, and repeat step (3).

[0006] Based on the above technical solution, step (3) includes the following steps: S3.1, determine whether the preparation injection signal S1 is received. If the preparation injection signal S1 is not received, repeat step (2); if the preparation injection signal S1 is received, proceed to step S3.2; S3.2, determine whether the actual injection signal S2 is received within the first delay time. If the actual injection signal S2 is not received, repeat step (2); if the actual injection signal S2 is received, proceed to step (4).

[0007] Based on the above technical solution, step (5) includes the following steps: S5.1, determine whether the injection state running time P2 reaches the injection column switching time T2. If P2 < T2, do not switch the suppressor column; if P2 ≥ T2, proceed to step S5.2; S5.2, determine whether the preparation injection signal S1 is received within the tail delay time. If the preparation injection signal S1 is not received, repeat step (2); if the preparation injection signal S1 is received, switch the position of the suppressor column and repeat step S3.2.

[0008] In a second aspect, the present invention provides a control device for an ion chromatography three-column suppressor, including an equilibrium time acquisition module, an equilibrium time judgment module, an injection signal judgment module, an injection time acquisition module, and an injection time judgment module. The equilibrium time acquisition module is configured to acquire the running time P1 of the three-column suppressor in the equilibrium state. The equilibrium time judgment module is configured to judge whether the equilibrium state running time P1 reaches the equilibrium column switching time T1. The injection signal judgment module is configured to judge whether an injection signal is received. The injection time acquisition module is configured to acquire the running time P2 of the three-column suppressor in the injection state. The injection time judgment module is configured to judge whether the injection state running time P2 reaches the injection column switching time T2.

[0009] In a third aspect, the present invention provides a control device for an ion chromatography three-column suppressor, including a processor and a memory storing program instructions. The processor is configured to execute the control method of the ion chromatography three-column suppressor as described in any one of the above embodiments when running the program instructions.

[0010] In a fourth aspect, the present invention provides a computer-readable storage medium storing program instructions, characterized in that when the program instructions are running, they are used to cause a computer to execute the control method of the ion chromatography three-column suppressor as described in any one of the above embodiments.

[0011] Compared with the related art, the beneficial effects of the present invention are as follows: 1. The control method of the ion chromatography triple-column suppressor in the present invention can ensure that the triple-column suppressor can be sampled at any time in any state, and the column can be regenerated in a timely and sufficient manner to ensure that the triple-column suppressor can work continuously online. Moreover, the setting of the balance column-switching time and the injection column-switching time enables the column being regenerated in the triple-column suppressor to be completely regenerated, so as to improve the accuracy of subsequent detections.

[0012] 2. During the ion chromatography detection process, switching the position of the suppressor column will cause abnormal peaks to appear on the chromatogram. In the control method of this application, sampling detection is started after receiving two signals, namely the ready-to-inject signal and the actual injection signal, which can avoid the appearance of abnormal peaks on the detection chromatogram and ensure the accuracy of the detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only one embodiment of the present invention. For those of ordinary skill in the art, without creative efforts, other implementation drawings can be obtained according to the provided drawings.

[0014] Figure 1 It is a flowchart of a control method for an ion chromatography triple-column suppressor provided by an embodiment of the present disclosure; Figure 2 It is a flowchart of another control method for an ion chromatography triple-column suppressor provided by an embodiment of the present disclosure; Figure 3 It is a schematic diagram of a control device for an ion chromatography triple-column suppressor provided by an embodiment of the present disclosure; Figure 4 It is a schematic diagram of another control device for an ion chromatography triple-column suppressor provided by an embodiment of the present disclosure. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0015] The present invention will be further described below in conjunction with the drawings and examples: The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the drawings, where the same or similar reference numerals represent the same or similar elements or elements with the same or similar functions from beginning to end. The embodiments described below by referring to the drawings are exemplary and are only used to explain the present invention, and should not be construed as a limitation of the present invention.

[0016] Currently, in an ion chromatograph, the suppressor is a crucial component, and its main function is to significantly improve the detection sensitivity by reducing the background conductivity. In ion chromatography analysis, the eluent itself is usually a strong electrolyte with a high conductivity, which can mask the signal of the target ions and lead to a decrease in detection sensitivity. The suppressor converts the background ions in the eluent into substances with low conductivity through chemical or electrochemical reactions, thereby reducing the background conductivity and enhancing the detection signal.

[0017] Among them, the suppressor includes two working states: the equilibrium state and the injection state. After the suppression column in the suppressor has been working for a period of time, it can be regenerated through the regeneration process and then continue the next operation. The regeneration process mainly includes two steps: water washing and acid washing. In the prior art, the regeneration process of the suppression column in the equilibrium state and the injection state is manually controlled, and there may be problems such as repeated use of the suppression column, untimely regeneration, or incomplete regeneration. The three-column suppressor for ion chromatography can switch the relative positions of the three columns by rotating the column body, thereby switching the three columns that are respectively connected to the acid washing solution, the water washing solution, and the injection solution, so that one of the columns of the suppressor injects the sample, and the other two columns can be regenerated synchronously.

[0018] Combined with Figure 1 As shown, the embodiments of the present disclosure provide a control method for a three-column suppressor of an ion chromatograph, including the following steps: (1) Obtain the running time P1 of the three-column suppressor in the equilibrium state; (2) Determine whether the running time P1 in the equilibrium state reaches the equilibrium column switching time T1. When P1 < T1, do not switch the column position of the suppressor. When P1 = T1, switch the column position of the suppressor; (3) Determine whether an injection signal is received. When no injection signal is received, repeat step (2). When an injection signal is received, go to step (4); (4) Start injection detection and obtain the running time P2 of the three-column suppressor in the injection state; (5) Determine whether the running time P2 in the injection state reaches the injection column switching time T2. When P2 < T2, do not switch the column of the suppressor. When P2 ≥ T2, switch the column position of the suppressor and repeat step (3).

[0019] By adopting the control method of the ion chromatography triple-column suppressor provided in the embodiments of the present disclosure, the switching action of the suppressor column can be controlled according to the relationship between the running time of the triple-column suppressor and the balance column switching time in the balanced state, which can ensure that after the column in the triple-column suppressor maintains for T1 time in the balanced state, when regeneration is required, the column position can be switched in time to start regeneration. When the triple-column suppressor is in the balanced state, the suppressor can be controlled according to whether an injection signal is received. When no injection signal is received, the control of the suppressor in the balanced state is continued. When an injection signal is received, the switching action of the suppressor column is controlled according to the relationship between the injection running time and the injection column switching time of the triple-column suppressor, which can ensure that after the column in the triple-column suppressor works for T2 time in the injection state, when regeneration is required, the column position can be switched in time for regeneration. Subsequently, it is repeatedly judged whether an injection signal is received. If no injection signal is received, the steps of the balanced state control method are repeated. If an injection signal is received, the steps of the injection state control method are repeated.

[0020] In this way, it can be ensured that the column in the triple-column suppressor can be switched in time in both the balanced state and the injection state, avoiding repeated injection of the column, and enabling the column to be regenerated in time for the next operation. Moreover, the setting of the balance column switching time and the injection column switching time enables the column being regenerated in the triple-column suppressor to be completely regenerated, so as to improve the accuracy of subsequent detection.

[0021] Based on the above technical solution, step (3) includes the following steps: S3.1, judge whether the ready injection signal S1 is received. If the ready injection signal S1 is not received, repeat step (2); if the ready injection signal S1 is received, go to step S3.2; S3.2, judge whether the actual injection signal S2 is received within the first delay time. If the actual injection signal S2 is not received, repeat step (2); if the actual injection signal S2 is received, go to step (4).

[0022] Optionally, step (5) includes the following steps: S4.1, judge whether the injection state running time P2 reaches the injection column switching time T2. If P2 < T2, do not switch the suppressor column; if P2 ≥ T2, go to step S4.2; S4.2, judge whether the ready injection signal S1 is received within the tail delay time. If the ready injection signal S1 is not received, repeat step (2); if the ready injection signal S1 is received, switch the position of the suppressor column and repeat step S3.2.

[0023] Combined with Figure 2As shown in the figure, an embodiment of the present disclosure provides another control method for an ion chromatography three-column suppressor, including the following steps: A1. Obtain the running time P1 of the three-column suppressor in the equilibrium state; A2. Determine whether the equilibrium state running time P1 reaches the equilibrium column switching time T1. If P1 < T1, do not switch the suppressor column position. If P1 = T1, switch the suppressor column position, and repeat step A2; A3. Determine whether the ready-to-inject signal S1 is received. If the ready-to-inject signal S1 is not received, repeat step A2; if the ready-to-inject signal S1 is received, proceed to step A4; A4. Determine whether the actual injection signal S2 is received within the initial delay time. If the actual injection signal S2 is not received, repeat step A2; if the actual injection signal S2 is received, proceed to step A5; A5. Determine whether the injection state running time P2 reaches the injection column switching time T2. If P2 < T2, do not switch the suppressor column; if P2 ≥ T2, proceed to step A6; A6. Determine whether the ready-to-inject signal S1 is received within the tail delay time. If the ready-to-inject signal S1 is not received, repeat step A2; if the ready-to-inject signal S1 is received, switch the suppressor column position and repeat step A4.

[0024] When using the control method for the ion chromatography three-column suppressor provided by the embodiment of the present disclosure, when judging whether the injection signal is received, it is divided into two steps. First, judge whether the ready-to-inject signal S1 is received. When the ready-to-inject signal S1 is received, then judge whether the actual injection signal S2 is received within the initial delay time. When the actual injection signal S2 is received, then perform the suppressor control steps in the injection state. If the actual injection signal is not received within the initial delay time, return to the suppressor control steps in the equilibrium state. In this way, if there is a situation where the staff gives the ready-to-inject signal but does not give the actual injection signal for a long time, it can be avoided that the three-column suppressor has been in a waiting state, and the three-column suppressor can return to the equilibrium state to carry out subsequent normal work.

[0025] In this way, during the ion chromatography detection process, switching the suppressor column position will cause abnormal peaks to appear on the chromatogram. In the control method of this application, starting the injection detection after determining that both the injection signal and the actual injection signal are received can avoid the appearance of abnormal column-switching peaks in the detection chromatogram and ensure the accuracy of the detection results.

[0026] Combined with Figure 3As shown in the figure, an embodiment of the present disclosure provides a control device for an ion chromatography three-column suppressor, including an equilibrium time acquisition module, an equilibrium time judgment module, an injection signal judgment module, an injection time acquisition module, and an injection time judgment module. The equilibrium time acquisition module is configured to acquire the running time P1 of the three-column suppressor in the equilibrium state. The equilibrium time judgment module is configured to judge whether the running time P1 in the equilibrium state reaches the equilibrium column switching time T1. The injection signal judgment module is configured to judge whether an injection signal is received. The injection time acquisition module is configured to acquire the running time P2 of the three-column suppressor in the injection state. The injection time judgment module is configured to judge whether the running time P2 in the injection state reaches the injection column switching time T2.

[0027] Combined with Figure 4 As shown in the figure, an embodiment of the present disclosure provides a control device for an ion chromatography three-column suppressor, including a processor and a memory storing program instructions. Optionally, the device may further include a communication interface and a bus. Among them, the processor, the communication interface, and the memory can complete mutual communication through the bus, and the communication interface can be used for information transmission. The processor is configured to execute the control method of the ion chromatography three-column suppressor as described in any one of the above embodiments when running the program instructions.

[0028] In addition, when the logical instructions in the above-mentioned memory are implemented in the form of software function units and sold or used as an independent product, they can be stored in a computer-readable storage medium.

[0029] The memory, as a computer-readable storage medium, can be used to store software programs and computer-executable programs, such as the program instructions / modules corresponding to the method in the embodiment of the present disclosure. The processor executes functional applications and data processing by running the program instructions / modules stored in the memory, that is, implements the control method of the ion chromatography three-column suppressor described in the above embodiments.

[0030] The memory may include a program storage area and a data storage area. Among them, the program storage area can store an operating system and application programs required for at least one function; the data storage area can store data created according to the use of the terminal device, etc. In addition, the memory may include a high-speed random access memory and may also include a non-volatile memory.

[0031] An embodiment of the present disclosure provides a computer-readable storage medium storing program instructions, and the program instructions, when running, are used to cause a computer to execute the control method of the ion chromatography three-column suppressor as described in any one of the above embodiments.

[0032] The technical solution of the embodiments of the present disclosure can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes one or more instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the method described in the embodiments of the present disclosure. The aforementioned storage medium may be a non-transitory storage medium, such as: a USB flash drive, a mobile hard disk, a read-only memory (ROM, Read-Only Memory), a random access memory (RAM, Random Access Memory), a magnetic disk, or an optical disc, and other media that can store program codes.

[0033] The above description and the drawings fully illustrate the embodiments of the present disclosure, enabling those skilled in the art to practice them. Other embodiments may include structural, logical, electrical, process, and other changes. The embodiments only represent possible variations. Unless explicitly required, individual components and functions are optional, and the order of operations can vary. Parts and features of some embodiments may be included in or replace parts and features of other embodiments. Moreover, the terms used in this application are only for describing the embodiments and are not used to limit the claims. As used in the description of the embodiments and the claims, unless the context clearly indicates otherwise, the singular forms "a", "an", and "the" are intended to also include the plural forms. Similarly, as used in this application, the term "and / or" refers to any and all possible combinations including one or more of the associated listed items. Additionally, when used in this application, the term "comprise" and its variants "comprises" and / or "comprising" etc. mean the presence of the stated features, wholes, steps, operations, elements, and / or components, but do not exclude the presence or addition of one or more other features, wholes, steps, operations, elements, components, and / or groups of these. Without further limitation, an element defined by the statement "comprising one..." does not exclude the presence of additional identical elements in the process, method, or device including the element. In this article, what each embodiment focuses on can be the differences from other embodiments, and the same or similar parts among the embodiments can be referred to each other. For the methods, products, etc. disclosed in the embodiments, if they correspond to the method part disclosed in the embodiments, the relevant parts can refer to the description of the method part.

[0034] Those skilled in the art can realize that the units and algorithm steps of each example described in combination with the embodiments disclosed herein can be implemented by electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are executed in a hardware or software manner may depend on the specific application and design constraints of the technical solution. The technician can use different methods for each specific application to implement the described functions, but such implementation should not be considered to exceed the scope of the embodiments of the present disclosure. Those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working processes of the systems, devices, and units described above can refer to the corresponding processes in the foregoing method embodiments and will not be elaborated herein.

[0035] In the embodiments disclosed herein, the disclosed methods, products (including but not limited to devices, equipment, etc.) can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units can be merely a logical function division, and there can be other division methods in actual implementation. For example, multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Additionally, the couplings or direct couplings or communication connections shown or discussed with each other can be through some interfaces. The indirect couplings or communication connections of devices or units can be electrical, mechanical, or other forms. The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they can be located in one place or distributed to multiple network units. Some or all of the units can be selected according to actual needs to implement this embodiment. Additionally, in the embodiments of the present disclosure, the functional units can be integrated in one processing unit, or each unit can exist physically alone, or two or more units can be integrated in one unit.

[0036] The flowcharts and block diagrams in the accompanying drawings illustrate the possible architectures, functions, and operations of systems, methods, and computer program products according to embodiments of the present disclosure. In this regard, each block in the flowchart or block diagram may represent a module, a segment of a program, or a part of code that contains one or more executable instructions for implementing a specified logical function. In some alternative implementations, the functions noted in the blocks may occur in a different order than that noted in the accompanying drawings. For example, two consecutive blocks may actually be executed substantially in parallel, or they may sometimes be executed in reverse order, depending on the functions involved. In the descriptions corresponding to the flowcharts and block diagrams in the accompanying drawings, the operations or steps corresponding to different blocks may also occur in a different order than that disclosed in the description, and sometimes there is no specific order between different operations or steps. For example, two consecutive operations or steps may actually be executed substantially in parallel, or they may sometimes be executed in reverse order, depending on the functions involved. Each block in the block diagram and / or flowchart, as well as combinations of blocks in the block diagram and / or flowchart, can be implemented by a dedicated hardware-based system that performs the specified functions or actions, or can be implemented by a combination of dedicated hardware and computer instructions.

[0037] The present invention has been described by way of example above, but the present invention is not limited to the above specific embodiments. Any modification or variation based on the present invention falls within the scope of protection of the present invention.

Claims

1. A control method for an ion chromatography triple-column suppressor, characterized in that, It includes the following steps: (1) Obtain the running time P1 of the three-column suppressor in the equilibrium state; (2) Determine whether the running time P1 in the equilibrium state reaches the equilibrium column-switching time T1. If P1 < T1, do not switch the column position of the suppressor. If P1 = T1, switch the column position of the suppressor; (3) Determine whether an injection signal is received. If no injection signal is received, repeat step (2). If an injection signal is received, proceed to step (4); (4) Start injection detection and obtain the running time P2 of the three-column suppressor in the injection state; (5) Determine whether the running time P2 in the injection state reaches the injection column-switching time T2. If P2 < T2, do not switch the column of the suppressor. If P2 ≥ T2, switch the column position of the suppressor and repeat step (3).

2. The control method of the ion chromatography triple-column suppressor according to claim 1, characterized in that, Step (3) includes the following steps: S3.1, Determine whether the ready-to-inject signal S1 is received. If the ready-to-inject signal S1 is not received, repeat step (2). If the ready-to-inject signal S1 is received, proceed to step S3.2; S3.2, Determine whether the actual injection signal S2 is received within the initial delay time. If the actual injection signal S2 is not received, repeat step (2). If the actual injection signal S2 is received, proceed to step (4).

3. The control method of the ion chromatography triple-column suppressor according to claim 2, wherein Step (5) includes the following steps: S5.1, Determine whether the running time P2 in the injection state reaches the injection column-switching time T2. If P2 < T2, do not switch the column of the suppressor. If P2 ≥ T2, proceed to step S5.2; S5.2, Determine whether the ready-to-inject signal S1 is received within the tail delay time. If the ready-to-inject signal S1 is not received, repeat step (2). If the ready-to-inject signal S1 is received, switch the column position of the suppressor and repeat step S3.

2.

4. A control device for an ion chromatography triple-column suppressor, characterized in that, It includes an equilibrium time acquisition module, an equilibrium time judgment module, an injection signal judgment module, an injection time acquisition module, and an injection time judgment module. The equilibrium time acquisition module is configured to obtain the running time P1 of the three-column suppressor in the equilibrium state. The equilibrium time judgment module is configured to determine whether the running time P1 in the equilibrium state reaches the equilibrium column-switching time T1. The injection signal judgment module is configured to determine whether an injection signal is received. The injection time acquisition module is configured to obtain the running time P2 of the three-column suppressor in the injection state. The injection time judgment module is configured to determine whether the running time P2 in the injection state reaches the injection column-switching time T2.

5. A control device for an ion chromatography triple-column suppressor, comprising a processor and a memory storing program instructions, characterized in that, The processor is configured to execute the control method of the ion chromatography three-column suppressor according to any one of claims 1 to 3 when running the program instructions.

6. A computer-readable storage medium storing program instructions, characterized in that, When the program instructions are running, they are used to cause the computer to execute the control method of the ion chromatography three-column suppressor according to any one of claims 1 to 3.

Images