Myopia medicine formula and preparation method thereof

Abstract

The invention discloses a myopia medicine formula and a preparation method thereof. The formula is composed of dactylicapnos scandens, honeysuckle flower extract and plant xanthophyll extract according to a ratio of 7: 2: 1. The dactylicapnos alkaloid can relax human eye ciliary muscle spasm, the honeysuckle flower extract can resist inflammation and improve eye environment, the plant xanthophyll can protect retina and resist oxidation, and the three components have a synergistic effect. According to the preparation method, macroporous adsorption resin is adopted to extract dactylicapnos scandens alkaloid, and the medicine dispensing method adopts a reinforced permeation technology to continuously dispense medicine per hour. The medicine can effectively treat pseudomyopia and eyestrain of teenagers, and is small in side effect and remarkable in effect.

Description

Technical Field

[0001] The present invention relates to the field of medical technology, in particular to a myopia drug formula and a preparation method thereof. Background Art

[0002] Adolescent pseudomyopia and eye fatigue caused by continuous close-up use have become common health issues in modern society. Medical research shows that approximately 68% of adolescents aged 12-18 experience temporary vision loss caused by ciliary muscle spasm. This persistent contraction of the ciliary muscle, caused by prolonged reading and screen time, can develop into true myopia if not promptly addressed. Typical symptoms include the visual fatigue triad: blurred vision, soreness around the eyes, photophobia, and tearing. Some patients also experience headaches and decreased concentration.

[0003] The present application aims to provide an eye drop for improving pseudomyopia in adolescents and eye fatigue caused by continuous close-range eye use. Summary of the Invention

[0004] The present invention provides a myopia drug formula and a preparation method thereof, and aims to solve the technical problem of providing an eye drop for improving pseudomyopia in adolescents and eye fatigue caused by continuous close-range eye use.

[0005] In order to achieve the above-mentioned object of the invention, the technical solution adopted by the present invention is:

[0006] On the one hand, the formula of myopia medicine includes alkaloids isolated from Zijinlong, honeysuckle extract, and plant lutein, with the mass ratio of 4~7:1~3:1~2.

[0007] Furthermore, the ratio of alkaloids isolated from Zijinlong, honeysuckle extract, and plant lutein is 7:2:1, respectively.

[0008] On the other hand, the method for preparing the myopia drug formulation is characterized by comprising the following steps:

[0009] The myopia medicine is obtained by mixing the Zijinlong alkaloids, honeysuckle extract and plant lutein in proportion.

[0010] Furthermore, the extraction method of Zijinlong alkaloids is:

[0011] The medicinal material of Zijinlong is crushed, sieved, and extracted with an appropriate solvent. After the extract is concentrated, it passes through a macroporous adsorption resin column and is eluted with ethanol solutions of different concentrations in sequence. The eluate containing alkaloids is collected, concentrated and dried to obtain the Zijinlong alkaloid extract.

[0012] The beneficial effects of the present invention are:

[0013] 1. Unique formula compatibility: The combination of dactylicapnos scandens, honeysuckle extract, and plant lutein plays a role in multiple aspects such as spasmolysis, anti-inflammation, protecting the retina, and antioxidation, forming a comprehensive treatment for eye problems. Compared with single-component drugs, the effect is more comprehensive and significant.

[0014] 2. Safe and without side effects: The dactylicapnos scandens component has no effect on heart rate, blood pressure, or pupils and has no side effects of atropine drugs. Both honeysuckle and plant lutein are natural ingredients with high safety and are suitable for teenagers.

[0015] 3. Innovative preparation and administration methods: Macroporous adsorption resin is used to extract dactylicapnos scandens alkaloids during the preparation process, improving the purity and extraction efficiency of the active ingredients; a unique eye-dropping method combined with enhanced penetration technology promotes drug absorption and accumulation, enhancing the therapeutic effect of the drug. Detailed implementation manners

[0016] The following further illustrates the detailed implementation manners of the present invention.

[0017] It should be noted that the words "front", "rear", "left", "right", "upper", and "lower" used in the following description refer to directions, and the words "inner" and "outer" refer to the directions towards or away from the geometric center of a specific component respectively.

[0018] In order to make the content of the present invention easier to be clearly understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention.

[0019] Embodiment 1

[0020] The drug formula for myopia includes the alkaloids isolated from dactylicapnos scandens, honeysuckle extract, and plant lutein, and their mass ratio is 4 - 7:1 - 3:1 - 2.

[0021] Preferably, the ratio of the alkaloids isolated from dactylicapnos scandens, honeysuckle extract, and plant lutein is 7:2:1 in sequence.

[0022] Alkaloids isolated from Zijinlong (Purple Dragon) have been clinically proven to be effective antispasmodic and analgesic drugs for the eyes. They act directly on smooth muscle and, unlike anticholinergic drugs, have no effect on heart rate, blood pressure, or pupils, nor do they have the side effects of atropine-like drugs. Honeysuckle is known in Traditional Chinese Medicine for its heat-clearing, detoxifying, and dispersing wind-heat. Its extract, when applied to the eyes, exhibits anti-inflammatory and antibacterial properties, alleviating potential ocular inflammation, improving the ocular microenvironment, and creating favorable conditions for drug absorption and efficacy. It can also help alleviate eye fatigue. Lutein, a key carotenoid, has unique effects on the eye. It filters harmful blue light, reducing retinal damage and protecting retinal cells. Lutein also possesses strong antioxidant properties, scavenging free radicals in the eye, alleviating oxidative stress and damage to ocular tissues, slowing aging, and improving eye muscle fatigue and pain.

[0023] In summary, the combination of the three has a unique synergistic effect; Zijinlong solves the key pathological factors of pseudomyopia by relaxing ciliary muscle spasms; honeysuckle extract is anti-inflammatory, improves the eye environment, reduces the adverse stimulation of external factors to the eyes, and promotes drug absorption; plant lutein protects the retina and anti-oxidation, working together from multiple links, it can not only effectively treat pseudomyopia, but also comprehensively improve eye conditions and relieve problems such as eye fatigue.

[0024] Example 2

[0025] The preparation method of the myopia drug formula comprises the following steps:

[0026] The myopia medicine, i.e. eye drops, is obtained by mixing the alkaloids of Zijinlong, the extract of honeysuckle and the plant lutein in proportion.

[0027] Furthermore, the extraction method of Zijinlong alkaloids is:

[0028] The medicinal material of Zijinlong is crushed, sieved, and extracted with an appropriate solvent (such as ethanol). After the extract is concentrated, it passes through a macroporous adsorption resin column and is eluted with ethanol solutions of different concentrations in sequence. The eluate containing alkaloids is collected, concentrated and dried to obtain the Zijinlong alkaloid extract.

[0029] Applicable symptoms: adjust vision. Used to treat pseudomyopia in adolescents and eye fatigue caused by continuous close-up use of vision.

[0030] Clinical application: 40 patients with pseudomyopia, aged 8 - 18 years old, all met the diagnostic criteria for pseudomyopia and had not used other ophthalmic therapeutic drugs in the past week. The eye drop application method of the present invention was adopted, with eye drops applied once every hour continuously, 1 - 2 drops each time. After applying the eye drops, the patient closed their eyes and rested for 5 minutes, and the eye drops were applied 8 times continuously. Visual acuity was measured 5 - 10 minutes after each application of the eye drops, and the data was recorded. The results showed that the total effective rate increased from 21.5% at the first time to 89.1% at the 8th time, and the marked effective rate increased from 21.5% at the first time to 89.1% at the 8th time. Both the total effective rate and the marked effective rate increased with the number of times of applying the eye drops. The effect of applying the eye drops three times was lower than that of the 8th time. After statistical analysis, the difference was significant (P < 0.05).

[0031] Usage method (eye drop application method): 1 - 2 drops each time. After applying the eye drops, the patient closes their eyes and rests for 5 minutes, and the eye drops are applied 5 times continuously.

[0032] The above are only the preferred embodiments of the present invention for patent, and are not intended to limit the present invention for patent. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention for patent shall be included within the protection scope of the present invention for patent.

Claims

1. A pharmaceutical formulation for myopia, characterized in that it comprises alkaloids isolated from Dactylicapnos scandens, honeysuckle extract, and plant lutein, and their mass ratio is (4 - 7):(1 - 3):(1 - 2).

2. The pharmaceutical formulation for myopia according to claim 1, characterized in that the proportions of alkaloids isolated from Dactylicapnos scandens, honeysuckle extract, and plant lutein are 7:2:1 in sequence.

3. Preparation method of myopia drug formula, characterized in that, It comprises the following steps Mix alkaloids of Dactylicapnos scandens, honeysuckle extract, and plant lutein in proportion to obtain the pharmaceutical for myopia.

4. The preparation method of the pharmaceutical formulation for myopia according to claim 3, characterized in that the extraction method of alkaloids of Dactylicapnos scandens is Crush the Dactylicapnos scandens medicinal materials, sieve them, extract with a suitable solvent, after concentrating the extract, pass it through a macroporous adsorption resin column, elute successively with ethanol solutions of different concentrations, collect the eluate containing alkaloids, concentrate and dry it to obtain the alkaloid extract of Dactylicapnos scandens.