Pharmaceutical composition and paste for preventing and treating eye asthenopia, myopia, presbyopia and xerophthalmia

Abstract

The invention relates to a pharmaceutical composition and paste for preventing and treating eye asthenopia, myopia, presbyopia and xerophthalmia and a preparation method of the pharmaceutical composition and paste. The pharmaceutical composition comprises the following components in percentage by weight: 50-80% of vaseline, 3-10% of paraffin, 1-5% of plant extract oil, 2-10% of traditional Chinese medicine extract ground powder, 0.5-2% of camphor, 0.1-2% of borneol and 0.5-3% of pearl layer powder. The traditional Chinese medicine composition is prepared from the following raw materials in percentage by weight: 0.1 to 1 percent of mirabilitum dehydratum, 0.1 to 0.2 percent of azone, 0.1 to 1 percent of artificial taurine, 0.1 to 0.5 percent of borax and 0.5 to 2 percent of menthol. The traditional Chinese medicine composition can be used for treating and relieving eye discomfort such as xerophthalmia, blurred vision, eye distension and eye pain; pseudomyopia can be treated after long-term use; the vision problems such as myopia and presbyopia are prevented, treated and relieved.

Description

BACKGROUND OF THE INVENTION

[0001] With the progress of technology and the popularization of electronic products such as mobile phones, TVs, and computers, people tend to use mobile phones and computers for long hours, watch TV for long hours, stay up late chatting and playing games online, face great learning pressure, study and write for long hours, etc. As a result, eye fatigue occurs due to excessive use of eyesight. Eye fatigue is a common ophthalmological disease, and its clinical manifestations include easy fatigue, eye swelling, eye tiredness, dryness, tearing, pain in the eyebrow arches, dizziness, etc., which make it impossible to sustain close work or reading for a long time. The basic pathological mechanism of eye fatigue is related to the imbalance of the liver, spleen, and kidney functions caused by various etiologies. Insufficient liver yin, excessive liver fire, deficiency of body fluids, and lack of moisture in the eyes; weakness of the spleen qi, failure of the clear yang to rise, failure of the turbid yin to descend, and the eyes not being warmed by the clear yang qi; deficiency of the kidney essence, which cannot reach the brain, resulting in emptiness of the brain marrow and the essence not nourishing the eyes; physical weakness, mental exhaustion over time, imbalance of nutrition, and long-term fatigue without rest, leading to blurred vision or even vision loss. Over time, it is easy to cause myopia, which directly affects people's lives and work. Eye fatigue has become a public health and social issue that attracts the attention of the whole society.

[0002] Myopia is also a common and frequently-occurring eye disease. There are various causes of myopia, such as myopia caused by poor eye use habits, genetic factors, application of drugs, etc. According to traditional Chinese medicine theory, myopia is mostly caused by disharmony of the zang-fu organs and meridians such as deficiency of the liver and kidney, deficiency of qi and blood, lack of nourishment of the eyes, qi stagnation and blood stasis, and blockage of the xuanfu, resulting in a decline in vision function. Since the pathogenesis of myopia is still not very clear, satisfactory results have not been achieved in terms of prevention and treatment. Currently, there are many methods for treating myopia on the market and in medical units. Most of them use glasses, health care instruments for treatment, and there are also vision correction instruments, pinhole glasses, laser therapy, magnetic therapy, electrotherapy, acupuncture and other methods, which are all common. Although these methods have some effects, they cannot cure the disease, and are prone to recurrence and aggravation of the condition. There are also some drugs on the market, such as western medicine preparations like atropine eye drops, and traditional Chinese medicine preparations like zengguang tablets, but the treatment time is long and the effect is not ideal. In severe cases, surgery is mostly used for treatment, but surgical treatment has great risks and many sequelae. In recent years, external preparations such as powders, ointments, and plasters, as well as internal preparations such as water, powders, pills, tablets, and capsules, in their formula compositions, some focus on nourishing the liver and kidney, some on promoting blood circulation to remove blood stasis, some on nourishing yin to promote fluid production, some on dispersing wind and removing dampness, clearing heat and purging fire, clearing heat and relieving restlessness, etc., and some on tonifying the middle qi and benefiting qi. From the existing publicly disclosed technical solutions, it can be seen that most of them ignore the nutritional deficiency of the eyes. If the nutrition of the eyes is supplemented, combined with promoting qi and blood circulation, nourishing the liver and kidney, balancing yin and yang, nourishing blood and calming the mind, antioxidant to eliminate free radicals to provide sufficient blood oxygen, so that the eye system can be nourished, eye fatigue and eye muscle spasm disappear, and the vision naturally returns to normal. Most of the early and middle-stage pseudo-myopia, mixed myopia, and astigmatism are formed due to eye fatigue and ciliary muscle spasm. Therefore, the combination of traditional Chinese medicines in the prescription is the basic guarantee for preventing and treating eye fatigue and myopia.

[0003] With the popularization, dependence and excessive use of mobile Internet + and smart phones, some adverse consequences have emerged among smart phone users, especially dry eye, blurred vision caused by the photosynthesis of blue light, eye fatigue, etc.; the mortality rate of eye cells damaged by blue light is too high, which is likely to cause cataracts. The light energy and heat energy can cause the drying up of the eye ducts, lacrimal sacs and lacrimal glands, resulting in dry eye and eye bags. The lymph nodes in the eye hip can hinder the discharge of eye cell secretions, causing poor eye circulation and the production of toxins. It is also another important origin of all eye diseases. Most of the medical technologies for vision are focused on surgical treatment technologies for existing problems, and there is a shortage of technologies in the direction of preventing, controlling and alleviating diseases before they occur. The present invention fills this gap in the field. Summary of the Invention

[0004] The purpose of the present invention is to propose a pharmaceutical composition and paste for preventing and treating eye fatigue, myopia, presbyopia and dry eye in view of the technical problems of eye fatigue and myopia, so as to achieve the advantages of scientific formula, reasonable structure, convenient use, rapid arrival of drug components at the affected area and good prevention and treatment effects.

[0005] In order to achieve the present invention, the following technical solutions are specifically adopted:

[0006] 1. A pharmaceutical composition and paste for preventing and treating eye fatigue, myopia, presbyopia and dry eye. Calculated based on 100 grams of the finished product, it is characterized by consisting of 50 - 80% of petrolatum, 3 - 10% of paraffin wax, 1 - 5% of plant extract oil, 2 - 10% of ground powder of traditional Chinese medicine extract, 0.5 - 2% of camphor, 0.1 - 2% of borneol, 0.5 - 3% of nacre powder, 0.1 - 1% of mirabilite, 0.1 - 0.2% of laurocapram, 0.1 - 1% of artificial taurine, 0.1 - 0.5% of borax, and 0.5 - 2% of menthol by weight percentage.

[0007] 2. A preferred pharmaceutical composition and paste for preventing and treating eye fatigue, myopia, presbyopia and dry eye according to the present invention. Calculated based on 100 grams of the finished product, it is characterized by consisting of 70 - 80% of petrolatum, 3 - 7% of paraffin wax, 3 - 5% of plant extract oil, 3 - 8% of ground powder of traditional Chinese medicine extract, 1 - 2% of camphor, 0.3 - 1% of borneol, 0.5 - 1.5% of nacre powder, 0.1 - 0.5% of mirabilite, 0.1 - 0.2% of laurocapram, 0.1 - 0.5% of artificial taurine, 0.1 - 0.3% of borax, and 0.5 - 1.5% of menthol by weight percentage.

[0008] 3. A more preferred pharmaceutical composition and paste for preventing and treating eye visual fatigue, myopia, presbyopia and dry eye. Based on 100 grams of the finished product, it is characterized by consisting of 80% petrolatum, 5% paraffin wax, 5% plant extract oil, 6% ground powder of traditional Chinese medicine extract, 1% camphor, 0.3% borneol, 0.9% nacre powder, 0.3% mirabilite, 0.1% laurocapram, 0.3% artificial taurine, 0.1% borax and 1% menthol by weight percentage.

[0009] 4. The above-mentioned pharmaceutical composition and paste for preventing and treating eye visual fatigue, myopia, presbyopia and dry eye. Based on 100 grams of the finished product, it is characterized in that the 6 grams of ground powder of traditional Chinese medicine extract in the 6% is made from the following raw materials by weight: (0.5 grams of dried ginseng, 0.3 grams of white chrysanthemum, 0.3 grams of trichosanthes root, 0.5 grams of andrographis paniculata leaves, 1.2 grams of indigo naturalis, 0.5 grams of liquorice, 0.5 grams of coptis, 0.4 grams of sophora subprostrata, 0.2 grams of human urine sediment, 0.2 grams of gypsum fibrosum, 0.3 grams of acorus calamus, 0.3 grams of cuscuta chinensis, 0.5 grams of cassia obtusifolia, 0.3 grams of tribulus terrestris. (All of the above materials are traditional Chinese medicine extracts passing through a 500-mesh sieve, and the finished powder materials of the traditional Chinese medicine extracts reaching 500 meshes). The 5 grams of plant extract oil in the 5% is made from the following raw materials by weight: 1.5 grams of peppermint oil, 1 gram of cinnamon oil, 0.5 gram of camphor oil, 1 gram of anise oil, 1 gram of ocimum gratissimum oil.

[0010] 5. The preparation method of the pharmaceutical composition and paste for preventing and treating eye visual fatigue, myopia, presbyopia and dry eye according to any one of 1 or 2 or 3 or 4 above, comprising the following steps:

[0011] (1) The raw material finished fine powders of dried ginseng, white chrysanthemum, trichosanthes root, andrographis paniculata leaves, indigo naturalis, liquorice, coptis, sophora subprostrata, human urine sediment, gypsum fibrosum, acorus calamus, cuscuta chinensis, cassia obtusifolia, tribulus terrestris extracts in parts by weight are all required to reach more than 500 meshes - between 800 meshes, and the water content is less than 2%;

[0012] (2) Weigh and stir evenly the medicinal materials obtained in step (1) to obtain a mixed powder;

[0013] (3) After step (2), camphor, borneol, mirabilite, borax, menthol, nacre powder are respectively ground into 500-mesh powder. Artificial taurine is ground into 800-mesh powder. Weigh and stir evenly to obtain a mixed powder;

[0014] (4) Weigh and stir evenly peppermint oil, cinnamon oil, camphor oil, anise oil, ocimum gratissimum oil to obtain a mixed oil;

[0015] (5) Weigh petrolatum and paraffin wax in proportion, add them to a cleaned emulsifying pot, heat and start stirring at a speed of 300 revolutions per minute, heat up to 100 °C. Keep stirring for 20 minutes for sterilization and then continue to stir and cool down;

[0016] (6) When the temperature drops to 80°C, pour the mixed powder obtained in step (2) into it, continue to keep it warm and stir at 80°C for 20 minutes, with a rotation speed of 800 revolutions per minute;

[0017] (7) When the temperature drops to 50°C, weigh the mixed powder obtained in step (3) according to the formula amount, wait until it cools down to 50 degrees and add it to the stirring for 20 minutes, with a rotation speed of 800 revolutions per minute;

[0018] (8) Add the mixed oil obtained in step (5) when the temperature drops to 40°C, stir for 5 minutes and then take out, with a rotation speed of 100 revolutions per minute.

[0019] 8. A pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye, according to claim 1 or 2 or 3, characterized in that it is composed of 7.6% of the pharmaceutical composition for preventing and treating ocular asthenopia and myopia, 7.4% of the skin penetration enhancer and drug odor volatilization promoter, and 85% of the wetting agent by weight percentage.

[0020] 9. The pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye described in items 7 and 8 above are composed of ginseng radix recens, flos chrysanthemi, trichosanthis radix, andrographis paniculata leaves, indigo naturalis, glycyrrhiza uralensis, coptis chinensis, sophora subprostrata, renzhongbai, calcite, acorus calamus, cuscutae semen, cassiae semen, tribuli fructus, borax, nacre powder, mirabilitum, artificial bezoar.

[0021] 10. The skin penetration enhancer and volatilizer described in items 7 and 8 above are composed of mentha arvensis oil, cinnamon oil, camphor oil, anise oil, ocimum gratissimum oil, camphor, borneol, laurocapram, menthol.

[0022] 11. The skin wetting agent described in items 7 and 8 above is vaseline and paraffin.

[0023] 12. The pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye described above are filled with the paste prepared by the above method into a medical eye mask cup, and directly volatilize and fumigate in the eye mask cup, or can also be applied to the eye surrounding acupoints for absorption with this product, and act through the eye surrounding meridians and percutaneous absorption. It has the effects of promoting blood circulation and dredging meridians, clearing the liver and improving eyesight, improving blood circulation, and improving ocular nutrition.

[0024] Technical features of the present invention:

[0025] 1. The traditional Chinese medicine extract of the product uses ingredients with high dryness and small molecular mesh numbers, and the traditional Chinese medicine powder reaches the state of broken walls, and the medicinal properties of the finished product are fully precipitated and highly active when heated;

[0026] 2. This product has strong volatility and good penetration, can dredge the lacrimal gland ducts and promote the production of tears, and reduce dry eye;

[0027] 3. The volatility of this product promotes the activation of eye cells and the opening of cell mouths, effectively absorbing effective nutrients and eye care ingredients to enhance cell energy, promote the metabolism of eye cells. The activation and stimulation degrees of the product have been repeatedly tested, and the evaporation ratio is in the best state, which is the state that least damages cells.

[0028] 4. The fumigation of this product promotes the metabolism of various components of the eyeball, promotes cell circulation and activates micro-resonance.

[0029] 5. The fumigation of the essence medicine oil of this product and subcutaneous penetration relieve the stiffness and spasm of the ciliary muscle, lens suspensory ligament and eye muscles. It has a health care effect on eye fatigue and deepening myopia.

[0030] 6. The combination of the essential oil compounded with medicine oil and the selected penetration enhancer and volatile agent used in this invention, together with the Chinese medicine extract with a mesh number of 500 - 800, highly improves the subcutaneous penetration ability of the product, and has strong volatility in the closed eye mask cup, fully achieving the new technology (black technology) of absorption through volatilization.

[0031] 7. This product is awaiting research on its effect of relieving glaucoma in promoting the blood circulation of the ophthalmic artery and vein.

[0032] 8. This product is awaiting research on its help in relieving cataract by promoting the circulation of eye cells.

[0033] Advantages of the invention:

[0034] 1. Aiming at the many causes of eye visual fatigue and myopia, this invention effectively combines the formula of the composition of this invention and the prepared paste. The components of the formula combination have the effects of clearing heat and detoxifying, clearing the liver and nourishing the liver, nourishing the kidney and improving eyesight, improving and promoting blood circulation around the eyes, improving the absorption of nutrients by eye cells, relieving spasm of eye muscles, calming the nerves, scavenging free radicals, accelerating metabolism, promoting the generation of visual cells, etc. It can promote the repair of optic nerve and retinal cells, enhance the stability of the vitreous body, and is used to treat various eye diseases such as visual fatigue, myopia, and dry eyes caused by various reasons. Its formula is reasonable and the curative effect is unique.

[0035] 2 The pharmaceutical composition and paste of the present invention for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye have a simple preparation method and are convenient to use, providing many conveniences for patients' self-use. Compared with traditional dry or wet medicated eye patches, the present invention uses a paste filled in a medical eye mask cup. This product directly volatilizes and fumigates in the eye mask cup, or can be applied by dotting the product around the eye acupoints for absorption, and acts through the meridians around the eyes and transdermal absorption. It has the effects of promoting blood circulation to dredge meridians, clearing the liver and improving eyesight, improving blood circulation, and improving eye nutrition. By releasing the drug for a long time and evenly, it stimulates the nerve receptors and terminal blood vessels around the eyes, effectively improves the blood circulation and nerve regulation around the eyes, improves the blood circulation and metabolism of eye tissues, and restores the physiological regulation of eye muscles, so as to achieve the purpose of improving asthenopia and effectively improving eyesight recovery.

[0036] 3. The paste of the present invention is applied around the eyes without using a heating eye mask. The purpose is to reduce the self-use ability and convenience of patients. Using a heating eye mask may lead to uneven drug release due to poor personal control and requires the care of others, which is extremely inconvenient for users. The product of the present invention is more convenient to use. Clinical verification has proved that the product of the present invention is used for the treatment of asthenopia and myopia, with a short treatment cycle, high cure rate, definite curative effect and no recurrence; the product of the present invention has a wide range of applicable populations, especially for those with asthenopia caused by high work pressure, long-term use of computers, long-term writing, and lack of rest during reading, as well as early treatment and early benefit for adolescent myopia patients with intense academic work, which has important practical significance. Detailed implementation mode

[0037] The following further describes the present invention in detail with specific embodiments for better understanding of the present invention.

[0038] Embodiment:

[0039] Preparation of a pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye:

[0040] (1) Calculated by 100 grams of finished product, the ground powder of traditional Chinese medicine extract is made from the following raw materials in parts by weight: 0.5 grams of ginseng radix, 0.3 grams of flos chrysanthemi, 0.3 grams of trichosanthis radix, 0.5 grams of andrographis paniculata leaves, 1.2 grams of indigo naturalis, 0.5 grams of glycyrrhiza uralensis, 0.5 grams of coptidis rhizoma, 0.4 grams of sophora subprostrata root, 0.2 grams of human urine sediment, 0.2 grams of gypsum rubrum, 0.3 grams of acorus calamus, 0.3 grams of cuscuta chinensis, 0.5 grams of cassia obtusifolia, 0.3 grams of tribulus terrestris. The extracts are all required to be fine powder of raw material products with a mesh size of more than 500 meshes - between 800 meshes, and the water content is less than 2% w / w;

[0041] (2) Weigh the raw materials in parts by weight obtained in step (1) and stir evenly to obtain a mixed powder;

[0042] (3) After step (2), 1% camphor, 0.3% borneol, 0.9% nacre powder, 0.3% mirabilite, 0.1% laurocapram, 0.3% artificial taurine, 0.1% borax, and 1% menthol are weighed respectively. The weighed parts are stirred evenly to obtain a mixed powder;

[0043] (4) Peppermint oil, cinnamon oil, camphor oil, anise oil, and ocimum basilicum oil are weighed (for 100 g of the finished product, the plant extract oil is made from the following weighed parts of raw materials: 1.5 g of peppermint oil, 1 g of cinnamon oil, 0.5 g of camphor oil, 1 g of anise oil, and 1 g of ocimum basilicum oil) and stirred evenly to obtain a mixed oil;

[0044] (5) Weigh vaseline and paraffin in proportion, add them to a cleaned emulsifying pot, heat and start stirring at a speed of 300 revolutions per minute, heat up to 100 °C, keep stirring for 20 minutes for sterilization, and then continue stirring to cool down;

[0045] (6) When the temperature drops to 80 °C, the mixed powder obtained in step (2) is poured in, and stirring is continued at 80 °C for 20 minutes at a speed of 800 revolutions per minute;

[0046] (7) When the temperature drops to 50 °C, the mixed powder obtained in step (3) is weighed according to the formula amount and added when cooled down to 50 °C, and stirred for 20 minutes at a speed of 800 revolutions per minute;

[0047] (8) The mixed oil obtained in step (5) is added when the temperature drops to 40 °C, and stirred for 5 minutes at a speed of 100 revolutions per minute.

[0048] Usage method: The paste prepared by the above method is filled into a medical eye mask cup, and the volatile gas is directly fumigated in the eye mask cup, or the product can also be applied topically to the eye acupoints for absorption.

[0049] Applicable symptoms: Treat and relieve eye discomfort such as dry eyes, blurred vision, eye swelling and pain; long-term use can treat pseudomyopia; prevent, treat and relieve vision problems such as myopia and presbyopia.

[0050] Clinical data

[0051] I. Clinical observation of the present invention on eye fatigue

[0052] 1. Patient data:

[0053] There are 100 clinical cases. The main manifestations of the patients are eye swelling and pain, dryness, blurred vision, and increased bloodshot eyes; even mental restlessness and uneasiness.

[0054] 2. Treatment method:

[0055] The paste of the present invention is filled into two medical eye mask cups, with 5 g filled in each cup; the eye mask cups are buckled on the eyes to let the volatile gas in the paste eye mask cups of the present invention fumigate. Once in the morning and once in the evening, 20 minutes each time, and 15 days is a treatment course.

[0056] 3. Treatment results

[0057] Effect of using once: 98 patients used it once, and the blood streaks in the eyes decreased; 66 patients saw things clearer than before.

[0058] Effect of one treatment course: 88 people showed marked effect (symptoms basically disappeared); 10 people showed improvement (symptoms significantly improved); 2 people showed effectiveness (symptoms relieved).

[0059] It can be seen from the treatment results that the total effective rate of the present invention in treating eye visual fatigue is 100%, among which 88% showed marked effect, 10% showed improvement, and 2% showed effectiveness.

[0060] It can be seen from the treatment results that the non-woven fabric medicine bag containing paste of the present invention can nourish the liver and kidney, benefit essence and improve eyesight, improve microcirculation, increase blood flow in the eyes, clear the liver and improve eyesight, and calm the mind. It can effectively improve eye visual fatigue caused by general reasons.

[0061] II. Clinical observation of the present invention on myopia.

[0062] The usage method is the same as that for eye visual fatigue mentioned above. If the effect of one treatment course is not good, two to five treatment courses can be repeated as needed. 100 patients with mild and moderate myopia were clinically observed and treated. Myopia caused by heredity or trauma was excluded. Among them, mild myopia is within 300 degrees; moderate myopia is 300 - 600 degrees, and the main symptom is blurred vision.

[0063] Analysis of treatment results:

[0064] 90% of the patients used it once, and clinical symptoms and signs such as blurred vision when looking at distant objects were relieved;

[0065] 62 cases were cured, accounting for 62%. The cure standard is: symptoms and signs such as blurred vision when looking at distant objects disappear, and the visual acuity increases to 1.0 or above.

[0066] 12 cases showed marked effect, accounting for 12%. The marked effect standard is: clinical symptoms and signs such as blurred vision when looking at distant objects basically disappear, and the visual acuity increases by two levels or more but does not reach 1.0.

[0067] 17 cases showed effectiveness, accounting for 17%. The effectiveness standard is: the visual acuity increases by 1 - 2 levels.

[0068] 9 cases were ineffective, accounting for 9%. The ineffectiveness standard is: the visual acuity increases by less than 1 level or does not increase.

[0069] Note: Based on the international standard logarithmic visual acuity chart, Level 1 is one row.

[0070] The above embodiments are only the implementation manners for further describing the present invention through embodiments, but the protection scope of the present invention is not limited thereto. Without departing from the essence of the present invention, those skilled in the art can make various corresponding changes and modifications within the technical scope disclosed by the present invention, and all of them should fall within the protection scope of the present invention.

Claims

1. A pharmaceutical composition and paste for preventing and treating eye visual fatigue, myopia, presbyopia and dry eye. Calculated based on 100 grams of the finished product, it is characterized in that It is made up of, by weight percentage, 50 - 80% petrolatum, 3 - 10% paraffin wax, 1 - 5% plant extract oil, 2 - 10% ground powder of traditional Chinese medicine extract, 0.5 - 2% camphor, 0.1 - 2% borneol, 0.5 - 3% nacre powder, 0.1 - 1% mirabilite, 0.1 - 0.2% laurocapram, 0.1 - 1% artificial taurine, 0.1 - 0.5% borax, and 0.5 - 2% menthol.

2. The pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye according to claim 1, based on 100 grams of the finished product, is characterized in that It is made up of, by weight percentage, 70 - 80% petrolatum, 3 - 7% paraffin wax, 3 - 5% plant extract oil, 3 - 8% ground powder of traditional Chinese medicine extract, 1 - 2% camphor, 0.3 - 1% borneol, 0.5 - 1.5% nacre powder, 0.1 - 0.5% mirabilite, 0.1 - 0.2% laurocapram, 0.1 - 0.5% artificial taurine, 0.1 - 0.3% borax, and 0.5 - 1.5% menthol.

3. The pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye according to claim 1, based on 100 grams of the finished product, is characterized in that It is made up of, by weight percentage, 80% petrolatum, 5% paraffin wax, 5% plant extract oil, 6% ground powder of traditional Chinese medicine extract, 1% camphor, 0.3% borneol, 0.9% nacre powder, 0.3% mirabilite, 0.1% laurocapram, 0.3% artificial taurine, 0.1% borax, and 1% menthol.

4. The pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye according to claims 1-3, based on 100 grams of the finished product, are characterized in that The 6 grams of ground powder of traditional Chinese medicine extract of 6% is made from the following raw materials by weight: (0.5 grams of dried ginseng, 0.3 grams of white chrysanthemum, 0.3 grams of trichosanthis root, 0.5 grams of andrographis leaves, 1.2 grams of indigo naturalis, 0.5 grams of liquorice root, 0.5 grams of coptis root, 0.4 grams of sophora subprostrata root, 0.2 grams of human urine sediment, 0.2 grams of gypsum fibrosum, 0.3 grams of acorus calamus, 0.3 grams of cuscuta chinensis, 0.5 grams of cassia seed, 0.3 grams of tribulus terrestris. (All of the above materials are traditional Chinese medicine extracts passing through a 500 - mesh sieve, and the finished powder materials of traditional Chinese medicine extracts reaching 500 - mesh). The 5 grams of plant extract oil of 5% is made from the following raw materials by weight: 1.5 grams of peppermint oil, 1 gram of cinnamon oil, 0.5 grams of camphor oil, 1 gram of anise oil, 1 gram of ocimum gratissimum oil.

5. The preparation method of the pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye according to claim 4, wherein the ground powder of the traditional Chinese medicine extract, camphor, borneol, nacre powder, mirabilite, artificial bezoar, borax and menthol, characterized in that, It includes the following steps (1) The extracts of dried ginseng, white chrysanthemum, trichosanthis root, andrographis leaves, indigo naturalis, liquorice root, coptis root, sophora subprostrata root, human urine sediment, gypsum fibrosum, acorus calamus, cuscuta chinensis, cassia seed, and tribulus terrestris selected are required to be finished fine powders of raw materials with a mesh size above 500 - 800 meshes and a water content less than 2% w / w; (2) Weigh the raw materials in the weight parts obtained in step (1) and stir evenly to obtain a mixed powder; (3) After step (2), camphor, borneol, mirabilite, borax, menthol, and nacre powder are respectively ground into 500 - mesh powder. Artificial taurine is ground into 800 - mesh powder.

6. According to the preparation method of the pharmaceutical composition and paste for preventing and treating eye visual fatigue, myopia, presbyopia, and dry eye as described in claim 4, the plant extract oil is made from the following high - purity original extract oils by weight: peppermint oil, cinnamon oil, camphor oil, anise oil, ocimum gratissimum oil. Weigh the raw materials in the weight parts and stir evenly to obtain a mixed oil.

7. The preparation method of the pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye according to claim 1 or 2 or 3, characterized in that, It includes the following steps: (1) Weigh vaseline and paraffin in proportion, add them to a cleaned emulsifying pan, heat and start stirring at a speed of 300 revolutions per minute, and heat up to 100 °C. Keep stirring for 20 minutes for sterilization and then continue stirring to cool down; (2) According to step (2) of claim 5, when the temperature drops to 80 °C, pour in the ground powder of the traditional Chinese medicine extract and the mixed powder weighed in proportion, and continue stirring at 80 °C for 20 minutes at a speed of 800 revolutions per minute; (3) According to step (3) of claim 5, when the temperature drops to 50 °C, weigh the mixed powder ground from camphor, borneol, nacre powder, artificial bezoar, etc. according to the formula amount, and add it when the temperature drops to 50 °C and stir for 20 minutes at a speed of 800 revolutions per minute; (4) Weigh the mixed oil in proportion according to claim 6, add it when the temperature drops to 40 °C, and add laurocapram weighed in proportion according to claim 3 and stir for 5 minutes at a speed of 100 revolutions per minute.

8. The paste of a pharmaceutical composition for treating ocular asthenopia and myopia according to claim 1 or 2 or 3, characterized in that, It is composed of 7.6% of the pharmaceutical composition for preventing and treating ocular asthenopia and myopia, 7.4% of the skin penetration enhancer and drug odor volatilization promoter, and 85% of the wetting agent by weight percentage.

9. The paste according to claim 7 or 8, characterized in that, The pharmaceutical composition and paste for preventing and treating ocular asthenopia and myopia are composed of ginseng, white chrysanthemum, trichosanthes root, andrographis leaf, indigo naturalis, licorice, coptis, sophora subprostrata, human urine sediment, gypsum rubrum, acorus calamus, cuscuta chinensis, cassia seed, tribulus terrestris, borax, nacre powder, mirabilite, artificial bezoar.

10. The paste according to claim 7 or 8, characterized in that, The skin penetration enhancer and volatilizer are composed of peppermint oil, cinnamon oil, camphor oil, anise oil, ocimum gratissimum oil, camphor, borneol, laurocapram, menthol.

11. The paste according to claim 7 or 8, characterized in that, The skin wetting agent is vaseline and paraffin.

12. The above-mentioned pharmaceutical composition and paste for preventing and treating ocular asthenopia, myopia, presbyopia and dry eye are characterized in that, The paste prepared by the above method is filled into a medical eye mask cup, and the volatile gas is directly fumigated in the eye mask cup, or it can also be applied to the eye acupoints around the eyes for absorption by this product, and it takes effect through the meridians around the eyes and percutaneous absorption.