Traditional Chinese medicine composition for treating gastroesophageal disease as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating gastroesophageal disease, which at least comprises the following components in parts by weight: 27-33 g of dandelion, 27-33 g of solanum lyratum, 13-17 g of goat milk, 27-33 g of fig, 13-17 g of radix ophiopogonis, 10-14 g of dendrobe, 8-10 g of almond and 8-10 g of fructus aurantii. The preparation method of the traditional Chinese medicine composition for treating gastroesophageal disease comprises the following steps: mixing the raw materials, adding 400ml of clear water, boiling with strong fire, continuously decocting for 30 minutes, filtering and extracting liquid medicine; adding 400ml of clear water into medicine residues, boiling with strong fire, continuing to decoct for 30 minutes, filtering and extracting medicine liquid; and combining the medicine liquid extracted twice. The traditional Chinese medicine composition for treating gastroesophageal diseases can be used for treating gastroesophageal diseases caused by stomach heat and qi stagnation, yin deficiency and intestinal stagnation, and has the effects of clearing stomach and nourishing yin, and promoting the circulation of qi and regulating the middle warmer.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating gastroesophageal disease, a preparation method and an application thereof. Background Art

[0002] Gastroesophageal diseases, such as chronic superficial gastritis, chronic erosive gastritis, chronic atrophic gastritis, gastric polyps, post-polyp surgery, gastric stromal tumors, post-operative gastric cancer, post-chemotherapy gastric cancer, gastric ulcer, duodenal ulcer, duodenitis, reflux esophagitis, esophageal erosion, Barrett's esophagus, hiatal hernia, gastroesophageal reflux disease, and cardia inflammation, are characterized by stomach heat and yin deficiency, qi stagnation, and intestinal stagnation. Common symptoms include dull pain in the stomach, abdominal distension, a burning sensation in the stomach or behind the sternum, belching, nausea, noisy discomfort, a feeling of hunger but no appetite, dry throat and mouth, thirst, weight loss, or fever in the five hearts, dry and hard stools, a reddish tongue with cracks, a thin fur with little saliva or a thin, greasy, and rough fur, and a stringy or thready pulse.

[0003] For such diseases, there is a lack of effective Chinese medicine in the prior art. Summary of the Invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating gastroesophageal disease, as well as a preparation method and application thereof, which can treat gastroesophageal disease caused by stomach heat and qi stagnation, yin deficiency and intestinal knot, and has the effects of clearing the stomach, nourishing yin, promoting qi and harmonizing the middle.

[0005] In order to solve the above technical problems, the present invention specifically provides the following technical solutions:

[0006] The present invention provides a traditional Chinese medicine composition for treating gastroesophageal disease. The formula of the traditional Chinese medicine composition comprises at least:

[0007] 27-33 grams of dandelion, 27-33 grams of white taro, 13-17 grams of goat milk, 27-33 grams of fig, 13-17 grams of Ophiopogon japonicus, 10-14 grams of Dendrobium, 8-10 grams of almond, and 8-10 grams of Citrus aurantium.

[0008] Preferably, the formula of the Chinese medicine composition is:

[0009] 30 grams of dandelion, 30 grams of white peony root, 15 grams of goat's milk, 30 grams of fig, 15 grams of Ophiopogon japonicus, 12 grams of Dendrobium officinale, 9 grams of almond, and 9 grams of Citrus aurantium.

[0010] Preferably, the formula of the Chinese medicine composition is as follows, in parts by weight:

[0011] 27 grams of dandelion, 27 grams of white taro, 13 grams of goat milk, 27 grams of fig, 13 grams of Ophiopogon japonicus, 10 grams of Dendrobium, 8 grams of almond, and 8 grams of Citrus aurantium.

[0012] Preferably, the formula of the Chinese medicine composition is as follows, in parts by weight:

[0013] 33 g of Taraxacum mongolicum, 33 g of Solanum lyratum Thunb., 17 g of Codonopsis lanceolata Benth. et Hook., 33 g of Ficus carica L., 17 g of Ophiopogon japonicus (Thunb.) Ker-Gawl., 14 g of Dendrobium officinale Kimura et Migo, 10 g of Armeniaca vulgaris Lam. var. ansu Maxim., 10 g of Aurantii Fructus Immaturus.

[0014] Preferably, by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of Coptis chinensis Franch., Evodia rutaecarpa (Juss.) Benth., Fritillaria thunbergii Miq., and Os Sepiae.

[0015] Preferably, by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of Codonopsis pilosula (Franch.) Nannf., Atractylodes macrocephala Koidz., stir-fried Endoconcha Japonica, and Six-Flavor Powder.

[0016] Preferably, by weight parts, the formula of the traditional Chinese medicine composition further comprises one or any combination of Flos Chloranthi, Flos Rosae Rugosae, Flos Citriaurantii, and Flos Buddlejae.

[0017] In the second aspect of the present invention, a preparation method of a traditional Chinese medicine composition for treating gastroesophageal diseases is provided, which is characterized in that according to the formula of the traditional Chinese medicine composition, all traditional Chinese medicine raw materials are mixed, 400 ml of clear water is added, and after boiling with strong fire, it is continuously decocted for 30 minutes, and the medicinal liquid is filtered and extracted;

[0018] 400 ml of clear water is added to the medicinal residues, and after boiling with strong fire, it is continuously decocted for 30 minutes, and the medicinal liquid is filtered and extracted;

[0019] The medicinal liquids extracted twice are combined.

[0020] In the third aspect of the present invention, an application of a traditional Chinese medicine composition for treating gastroesophageal diseases is provided. The traditional Chinese medicine composition for treating gastroesophageal diseases is used to treat gastroesophageal diseases of stomach heat stagnation and yin deficiency with intestinal obstruction, and has the effects of clearing the stomach and nourishing yin, promoting qi flow and regulating the middle energizer.

[0021] The present invention has the following beneficial effects compared with the prior art: <U+ <U+

[0022] The present invention can treat gastroesophageal diseases of stomach heat stagnation and yin deficiency with intestinal obstruction, and has the effects of clearing the stomach and nourishing yin, promoting qi flow and regulating the middle energizer.

[0023] Taraxacum mongolicum clears heat and detoxifies, dispels carbuncles and dissipates nodules, and can also strengthen the stomach. Solanum lyratum Thunb., also known as Solanum lyratum Thunb., clears heat and promotes diuresis, detoxifies and reduces swelling, and also nourishes yin. The two herbs are the monarch herbs.

[0024] Codonopsis lanceolata Benth. et Hook., also known as Codonopsis lanceolata Benth. et Hook. and Codonopsis lanceolata Benth. et Hook., benefits qi and nourishes yin, warms and tonifies deficiency, and also detoxifies. Ficus carica L. nourishes yin and promotes fluid production, strengthens the spleen and promotes appetite, and also clears heat. The two herbs assist the monarch herbs to enhance the power of nourishing the stomach and protecting yin, and are the minister herbs. Ophiopogon japonicus (Thunb.) Ker-Gawl. and Dendrobium officinale Kimura et Migo benefit the stomach and promote fluid production, nourish yin and clear heat. Armeniaca vulgaris Lam. var. ansu Maxim. reduces adverse qi and moistens the intestine. Aurantii Fructus Immaturus promotes qi flow and soothes the middle energizer. They are all adjuvant herbs. The combination of all herbs exerts the effects of clearing heat and nourishing yin, regulating qi and relieving distension, and soothing the stomach and relieving pain. Detailed implementation manners

[0025] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0026] The present invention provides a traditional Chinese medicine composition for treating gastroesophageal diseases. According to parts by weight, the formula of the traditional Chinese medicine composition at least includes:

[0027] 27-33 grams of dandelion, 27-33 grams of solanum lyratum, 13-17 grams of codonopsis lanceolata, 27-33 grams of fig, 13-17 grams of ophiopogon japonicus, 10-14 grams of dendrobium, 8-10 grams of almond, and 8-10 grams of aurantii fructus immaturus.

[0028] Among them, dandelion clears heat and detoxifies, dispels carbuncles and dissipates nodules, and also strengthens the stomach. Solanum lyratum, also known as white hair vine, clears heat and promotes diuresis, detoxifies and reduces swelling, and also nourishes yin. The two herbs are used as the monarch herbs.

[0029] Codonopsis lanceolata, also known as lance asiabell root and four-leaf ginseng, benefits qi and nourishes yin, moistens and tonifies deficiency, and also detoxifies. Fig nourishes yin and promotes fluid production, strengthens the spleen and promotes appetite, and also clears heat. The two herbs assist the monarch herbs to enhance the power of nourishing yin and protecting the stomach, and are used as the minister herbs. Ophiopogon japonicus and dendrobium benefit the stomach and promote fluid production, nourish yin and clear heat. Almond reduces adverse qi and lubricates the intestines. Aurantii fructus immaturus promotes qi movement and soothes the middle. They are all used as the assistant herbs. The combination of various herbs plays the role of clearing heat and nourishing yin, regulating qi and relieving fullness, and soothing the stomach and relieving pain.

[0030] The present invention can treat gastroesophageal diseases such as stomach heat stagnation and yin deficiency with intestinal obstruction, and has the effects of clearing the stomach and nourishing yin, regulating qi and harmonizing the middle.

[0031] Example 1:

[0032] The formula of the traditional Chinese medicine composition is 30 grams of dandelion, 30 grams of solanum lyratum, 15 grams of codonopsis lanceolata, 30 grams of fig, 15 grams of ophiopogon japonicus, 12 grams of dendrobium, 9 grams of almond, and 9 grams of aurantii fructus immaturus.

[0033] Example 2:

[0034] The formula of the traditional Chinese medicine composition is 27 grams of dandelion, 27 grams of solanum lyratum, 13 grams of codonopsis lanceolata, 27 grams of fig, 13 grams of ophiopogon japonicus, 10 grams of dendrobium, 8 grams of almond, and 8 grams of aurantii fructus immaturus.

[0035] Example 3:

[0036] The formula of the traditional Chinese medicine composition is 33 grams of dandelion, 33 grams of solanum lyratum, 17 grams of codonopsis lanceolata, 33 grams of fig, 17 grams of ophiopogon japonicus, 14 grams of dendrobium, 10 grams of almond, and 10 grams of aurantii fructus immaturus.

[0037] The preparation method comprises the following steps: mixing all the Chinese medicinal raw materials according to the formula of the Chinese medicinal composition, adding 400 ml of water, boiling over high heat, and then decocting for 30 minutes, filtering and extracting the medicinal liquid;

[0038] Add 400ml of water to the residue, bring to a boil over high heat and continue decocting for 30 minutes, then filter and extract the medicinal liquid;

[0039] Combine the two extraction solutions.

[0040] Some gastroesophageal diseases are manifested by dry mouth and throat, belching and acid reflux, abdominal pain and bloating, heartburn and noisy mouth, dry stool, red tongue and rough coating. The basic pathogenesis is stomach heat and qi stagnation, and yin deficiency and intestinal knot.

[0041] For example, dull pain in the epigastrium can be caused by stomach heat, which disrupts the stomach meridians. Yin deficiency deprives the stomach of nourishment, leading to pain. Qi stagnation leads to obstruction and pain. The Complete Works of Jingyue states that "pain that is gradual and unresolved is often caused by deficiency." Regarding treatment, The True Transmission of Medicine states that "the location of pain varies depending on the qi, blood, yin, and yang. If we generalize treatment by promoting qi circulation and removing stagnation, it would be reasonable to say that if the qi is unblocked, there will be no pain. However, the methods for unblocking the qi vary... Deficiency can be helped to unblock the qi." This is based on an understanding of the pathogenesis and syndrome differentiation of these gastroesophageal diseases.

[0042] When considering treatment strategies, the following three aspects can be considered: first, clearing stomach heat and eliminating pathogenic factors that erode the stomach meridians, using herbs such as dandelion and white twig; second, nourishing stomach yin and ensuring the nourishment of the stomach's yin fluid, using herbs such as goat's milk, fig, ophiopogon japonicus, and dendrobium; and third, regulating stomach qi and maintaining the smooth flow of qi in the middle burner, using herbs such as apricot kernel and fructus aurantii. In short, clearing heat and nourishing yin, promoting qi circulation and harmonizing the stomach, can achieve the goal of eliminating bloating and relieving pain.

[0043] The following provides specific clinical data:

[0044] Wang, a 72-year-old female, presented with recurrent epigastric discomfort for over three months. She reported experiencing epigastric discomfort for three months, along with abdominal distension, frequent belching, fatigue, and anxiety. She reported restful sleep and a normal appetite, but with dry, hard stools. Examination revealed a tired appearance, a thin figure, and an anxious demeanor. Her heart and lungs were normal, with slight tenderness beneath the xiphoid process. Her tongue was red and cracked, with a thin, greasy coating, and a thready, wiry pulse.

[0045] A gastroscopy report from two years ago showed chronic non-atrophic gastritis with erosions. The patient also had a history of anxiety.

[0046] Syndrome differentiation: stomach heat and yin deficiency, spleen deficiency and qi stagnation.

[0047] Example 1 is preferred, and the gastroesophageal disease is treated with a traditional Chinese medicine composition for treating gastroesophageal disease.

[0048] Prescription: The formula of the Chinese medicine composition is 30 grams of dandelion, 30 grams of white peony root, 15 grams of goat milk, 30 grams of fig, 15 grams of Ophiopogon japonicus, 12 grams of Dendrobium, 9 grams of almond, and 9 grams of Citrus aurantium.

[0049] Take 7 doses, 1 dose per day, divided into 2 times, once in the morning and once in the afternoon.

[0050] Follow-up visit: The discomfort of abdominal distension and fullness was relieved, the frequency of belching decreased, there was phlegm in the throat, the stool was smoother than before, the tongue was slightly red, the tongue coating was thin, and the pulse was thready.

[0051] For the syndrome differentiation of this type of gastroesophageal disease, it can be clinically divided into two categories: deficiency and excess. For the excess syndrome, the main pattern is stomach heat and qi stagnation, with more acute distending pain and resistance to pressure, and the treatment is more likely to achieve results; for the deficiency syndrome, the main patterns are yin deficiency and qi deficiency, with more slow distending pain and preference for pressure, and the condition is lingering and difficult to cure. This is the key to syndrome differentiation. The treatment of epigastric distending pain with Shuangying Ruguojian is mainly based on the co-existence of excess and deficiency patterns of stomach heat, qi stagnation, yin deficiency in the patient. When formulating the specific prescription and medication, it is necessary to combine the diversity of clinical symptoms, pay attention to careful syndrome differentiation, and flexibly implement the treatment.

[0052] First, for clearing heat with bitter-cold herbs, it is necessary to avoid damaging the stomach, and more relatively mild heat-clearing herbs are selected, such as dandelion, codonopsis lanceolata, forsythia, and oldenlandia diffusa.

[0053] Second, for regulating qi without damaging yin, flower herbs can be selected for their characteristics of being mild, fragrant, and soothing, such as adding mume flower, rose flower, daidai flower, and fingered citron flower.

[0054] Third, the syndrome of stomach heat, qi stagnation, and yin deficiency is closely related to the disharmony of liver and spleen functions. If there is liver depression transforming into fire, with restlessness and acid regurgitation, it is advisable to add coptis chinensis, evodia rutaecarpa, fritillaria thunbergii, and cuttlebone; if the spleen fails to transport and transform, with poor appetite, it is advisable to add codonopsis pilosula, atractylodes macrocephala, stir-fried gallus gallus domesticus gigeriae gallus, and medicated leaven.

[0055] The above embodiments are only exemplary embodiments of the present application and are not used to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements within the essence and protection scope of the present application, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the present application.

Claims

1. A traditional Chinese medicine composition for treating gastroesophageal diseases, characterized in that, By weight, the formula of the traditional Chinese medicine composition at least includes: 27-33 grams of dandelion, 27-33 grams of solanum lyratum, 13-17 grams of codonopsis lanceolata, 27-33 grams of fig, 13-17 grams of ophiopogon japonicus, 10-14 grams of dendrobium officinale, 8-10 grams of almond, 8-10 grams of aurantii fructus immaturus.

2. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, wherein, By weight, the formula of the traditional Chinese medicine composition is: 30 grams of dandelion, 30 grams of solanum lyratum, 15 grams of codonopsis lanceolata, 30 grams of fig, 15 grams of ophiopogon japonicus, 12 grams of dendrobium officinale, 9 grams of almond, 9 grams of aurantii fructus immaturus.

3. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, characterized in that, By weight, the formula of the traditional Chinese medicine composition is: 27 grams of dandelion, 27 grams of solanum lyratum, 13 grams of codonopsis lanceolata, 27 grams of fig, 13 grams of ophiopogon japonicus, 10 grams of dendrobium officinale, 8 grams of almond, 8 grams of aurantii fructus immaturus.

4. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, wherein, By weight, the formula of the traditional Chinese medicine composition is: 33 grams of dandelion, 33 grams of solanum lyratum, 17 grams of codonopsis lanceolata, 33 grams of fig, 17 grams of ophiopogon japonicus, 14 grams of dendrobium officinale, 10 grams of almond, 10 grams of aurantii fructus immaturus.

5. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, wherein, By weight, the formula of the traditional Chinese medicine composition further includes one or any several of coptis chinensis, evodia rutaecarpa, fritillaria thunbergii, and cuttlebone.

6. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, wherein, By weight, the formula of the traditional Chinese medicine composition further includes one or any several of codonopsis pilosula, atractylodes macrocephala, stir-fried endothelium corneum gigeriae galli, and medicated leaven.

7. The traditional Chinese medicine composition for treating gastroesophageal diseases according to claim 1, characterized in that, By weight, the formula of the traditional Chinese medicine composition further includes one or any several of green plum blossom, rose flower, daidai flower, and fingered citron flower.

8. A method for preparing a traditional Chinese medicine composition for treating gastroesophageal diseases as described in any one of claims 1-7, characterized in that, According to the formula of the traditional Chinese medicine composition, all the traditional Chinese medicine raw materials are mixed, 400 ml of clear water is added, and after boiling over high heat, it is continuously decocted for 30 minutes, and the medicinal liquid is filtered and extracted; [[ID= ​ 9. Use of a traditional Chinese medicine composition for treating gastroesophageal diseases according to any one of claims 1-7, characterized in that, ​