Device and method for quantifying a liquid

Abstract

The invention relates to the field of liquid treatment, and discloses a liquid quantitative treatment scheme which comprises a container used for containing liquid to be extracted or discharged; and a slim tube, the slim tube comprising: a through-flow line extending outwardly from the inside of the container to a bifurcation point; the first branch is communicated with the through-flow pipeline and extends to a first port from the bifurcation point; the second branch is communicated with the through-flow pipeline and extends to a second port from the bifurcation point; wherein a peristaltic pump is arranged in at least one of the through-flow pipeline, the first branch and the second branch in a series connection mode, and a stop valve or another peristaltic pump is arranged in at least the other of the through-flow pipeline, the first branch and the second branch in a series connection mode. And a predetermined volume of liquid between the bifurcation point and the first port or the second port can be intercepted.

Description

[0001] This application is a divisional application of a Chinese patent application with the application number 2021100876082, the application date of January 22, 2021, and the title of "Device for Quantitatively Treating Liquids". Technical Field

[0002] This application relates to the field of liquid treatment, analysis or detection. Specifically, it relates to a device for quantitatively treating liquids. Background Art

[0003] Currently, the treatment and / or analysis of liquids are involved in many technical fields. For example: in the medical field, food field, laboratory analysis, agriculture, forestry, animal husbandry and fishery and other fields, the analysis of samples requires quantitative treatment of the samples to be tested and reagents. Another example is in the water quality detection in the environmental protection field, where it is necessary to intercept a quantitative small test sample and perform detection and analysis on the small test sample. Among them, the accuracy of the intercepted amount of the liquid to be tested has a crucial direct impact on the detection result. Once the test sample cannot be accurately intercepted or the sampling volume of the liquid is not known, it will lead to a large error in the detection result.

[0004] Traditionally, although many analytical instruments or liquid treatment devices can perform precise liquid feeding within a relatively small volume range (such as 0.05 ml to 2 ml), their objects to be detected are usually relatively clear and clean liquids after pretreatment such as flocculation precipitation and filtration in the laboratory state, and the costs of liquid pre-treatment devices and labor are usually high.

[0005] This traditional solution is difficult to meet the actual working conditions requirements of the current industrial community because it is difficult to ensure the cleanliness of the liquid to be tested in some actual working conditions. On the other hand, once the liquid to be tested is pretreated, the clean liquid is obviously different from the actual liquid at the first site (such as COD, total phosphorus, total nitrogen, etc. in water quality detection), which is very likely to affect the measurement accuracy. Moreover, the suspended solids or impurities in the liquid may even block the pretreatment pipeline. Another example is in the field of on-line monitoring under harsh working conditions, such as in the on-line detection fields of electroplating treatment solutions, wet smelting ore solutions, environmental protection sewage waste water, etc. The traditional technical solutions cannot achieve precise quantitative detection of such harsh liquids to be tested under such working conditions. In particular, there is a lack of a trace (such as 0.05 - 2 ml) liquid quantification technology that can be maintained relatively easily or even without maintenance at a relatively low cost and over a relatively long period of time.

[0006] In addition, a typical quantitative metering flow path currently widely used in the field of analytical instruments and liquid processing is the "sequential injection" liquid inlet metering technology. This flow path technology has good stability, but in the past decade, with the emergence of a series of demanding new requirements for instruments and equipment such as low cost, high precision, taking into account both micro-inlet volume (such as 0.05-2 ml) and regular inlet volume (such as 2-10 ml) and rapid measurement and detection, several inherent defects of the traditional sequential injection liquid inlet metering technology have become increasingly apparent: for example, first, due to the need to apply multi-channel switching valves (or valve groups) and liquid inlet metering and detection devices, the cost of flow path devices in such traditional devices is relatively high; secondly, in the flow path scheme of such traditional devices, the liquid inlet and discharge need to be carried out sequentially in a transfer manner, so the operation steps are relatively It is complicated and takes a long time, which leads to relatively low overall work efficiency; thirdly, a more serious defect is that if the detection process requires continuous feeding of water samples and several different reagents under certain working conditions, the flow path in the traditional solution can only measure these water samples and reagents in sequence, and sometimes the pipeline needs to be fully cleaned when the next reagent is fed in, which causes the overall analysis process of the instrument to take too long, seriously affecting work efficiency; finally, in the flow path of the traditional device, the transfer pipeline has a long stroke, which can easily cause liquid to stick to the wall or remain inside the catheter and device, resulting in low measurement accuracy when performing micro-liquid processing.

[0007] In view of this, how to overcome at least some of the above-mentioned technical defects in traditional solutions, at least to a certain extent, has become a technical problem that needs to be urgently solved in this field. Summary of the Invention

[0008] The present application provides a novel solution for quantitatively processing liquids. To achieve the above-mentioned purpose, the present application provides a device for quantitatively processing liquids, the device comprising: a container for containing liquid to be extracted; and a capillary tube, the capillary tube comprising: a flow line extending outward from the interior of the container to a bifurcation point; a first branch communicating with the flow line and extending from the bifurcation point to a first port; and a second branch communicating with the flow line and extending from the bifurcation point to a second port; wherein a peristaltic pump is provided in series in at least one of the flow line, the first branch, and the second branch, and a shut-off valve or another peristaltic pump is provided in series in at least another of the flow line, the first branch, and the second branch, so as to be able to intercept a predetermined volume of liquid between the bifurcation point and the first port or the second port; wherein the pore size of the capillary tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.2 mm to 2 mm.

[0009] Preferably, the container is a container that is open to the atmosphere, and the flow conduit extends from the interior of the container to the outside of the container.

[0010] Preferably, a first peristaltic pump or a third peristaltic pump is serially arranged in the flow-through pipeline and / or the first branch, a second peristaltic pump or a stop valve is serially arranged in the second branch, and the peristaltic pump and / or the stop valve cooperate to enable the liquid with a predetermined volume in the predetermined section between the bifurcation point and the first port to flow out of the first port or the second port. In the working state, the first peristaltic pump is used to suck the liquid in the container and make the liquid overflow from the first port; in the non-working state, both the first peristaltic pump and the second peristaltic pump are in the cut-off state.

[0011] Preferably, the first peristaltic pump is serially arranged in the first branch, a first stop valve is serially arranged in the flow-through pipeline, and a second stop valve or a second peristaltic pump is serially arranged in the second branch; or the first peristaltic pump is serially arranged in the first branch, the flow-through pipeline is a through pipe, and a second stop valve or a second peristaltic pump is serially arranged in the second branch; or the first peristaltic pump is serially arranged in the first branch, a third peristaltic pump is serially arranged in the flow-through pipeline, and a second peristaltic pump or a second stop valve is serially arranged in the second branch; or the third peristaltic pump is serially arranged in the flow-through pipeline, a first stop valve is serially arranged in the first branch, and a second peristaltic pump or a second stop valve is serially arranged in the second branch; or the first branch is a through pipe, a second peristaltic pump or a second stop valve is serially arranged in the second branch, and the first peristaltic pump is serially arranged in the flow-through pipeline.

[0012] Preferably, the first branch is a pipeline that extends obliquely from the bifurcation point to the first port, preferably extending obliquely upward or obliquely downward.

[0013] Preferably, a liquid detector is arranged at a position of the first branch adjacent to the first port, and the liquid with a predetermined volume between the bifurcation point and the first port is the liquid between the bifurcation point and this liquid detector; and / or a liquid detector is arranged at a position of the second branch adjacent to the second port, and the liquid with a predetermined volume between the bifurcation point and the second port is the liquid between the bifurcation point and this liquid detector.

[0014] Preferably, the liquid between the bifurcation point and the liquid detector is the liquid from the bifurcation point to a predetermined offset point based on this liquid detector.

[0015] Preferably, the container is a closed container that is not in communication with the atmosphere, and a pressurizing device for increasing the air pressure in the container is connected to this closed container, and the flow-through pipeline extends out of the container from the inside of the container.

[0016] Preferably, a first stop valve is serially arranged in the flow-through pipeline, and a third peristaltic pump is serially arranged in the second branch. The third peristaltic pump cooperates with the first stop valve and the pressurizing device to enable the liquid with a predetermined volume between the bifurcation point and the first port to flow out of the first port or the second port.

[0017] Preferably, a second stop valve is serially arranged in the first branch, and the third peristaltic pump also serves as the pressurizing device.

[0018] Preferably, the pressurizing device is a heater arranged in the container for heating the air in the container; or the pressurizing device includes an auxiliary container communicated with the atmosphere, and the auxiliary container is communicated with the container through a fourth peristaltic pump to pump the liquid in the auxiliary container into the container; or the pressurizing device includes a fourth peristaltic pump, and the liquid container is communicated with the external atmosphere through the fourth peristaltic pump.

[0019] Preferably, a liquid detector is arranged at a position of the first branch adjacent to the first port, and the liquid with a predetermined volume between the bifurcation point and the first port is the liquid between the bifurcation point and the liquid detector; and / or an extension section extending downward is arranged at the first port, preferably vertically downward.

[0020] Preferably, the liquid between the bifurcation point and the liquid detector is the liquid from the bifurcation point to a predetermined offset point based on the liquid detector.

[0021] Through the technical solution of the present application, by utilizing the working characteristics of the thin tube, the peristaltic pump and / or the stop valve, at least some of the following beneficial technical effects can be achieved.

[0022] For example, by adopting a combination of a thin tube, a peristaltic pump and / or a stop valve, and by simple control of the peristaltic pump and the stop valve, it is possible to simply fill the selected constant-volume thin tube with the liquid to be metered for inlet with accurate constant volume through overflow. At the same time, through the overflow method, the bubbles that may be generated at the beginning of the inlet can also be eliminated, so as to achieve high-precision inlet of micro liquid volume. In addition to accurately constant-volume the volume of the liquid to be measured, the technical solution of the present application can preferably also achieve high-precision metering and rapid inlet of the liquid, and convey the liquid with a high-precision volume to the subsequent processing container or process.

[0023] Again, in the technical solution of the present application, the flow path topology structure is very simple, the types of required flow path devices are few, and the devices are simple and convenient for mold opening and mass production. Some flow paths only require one device (peristaltic pump) even except for the conduit, so its cost can be greatly reduced, the assembly in the production and manufacturing process is very simple, and the daily maintenance and repair in the use process are also very convenient.

[0024] In addition, in the technical solution of the present application, most of the (miniature) peristaltic pumps and stop valves currently used in the industrial field are adopted, and at the same time, cheap thin tubes are used as the constant volume tubes. Such components are not only cheap but also have stable and reliable performance. Therefore, compared with the traditional solution, the cost can be greatly reduced and good reliability can be obtained.

[0025] In addition, in the technical solution of the present application, as described above, the use of the flow path scheme design can achieve high-precision constant volume metering. In the preferred case, a peristaltic pump (since the peristaltic pump tube is directly connected to the thin tube, compared with the stop valve, the peristaltic pump can more easily eliminate the dead volume interference problem of the residual liquid) can be used to achieve a higher-precision liquid inlet operation.

[0026] In addition, in the present application, not only can the expansion and modular combination of various flow path schemes be conveniently realized, but also the "concurrent micro-equivalent rapid liquid inlet technology" similar to "loading the magazine" can be realized in some combined flow path schemes: in the traditional sequential liquid inlet mode (such as the "sequential injection" liquid inlet technology), since there is usually only one constant volume metering device and one peristaltic pump, the water sample or reagent must be driven into the constant volume metering device by the peristaltic pump in sequence, and finally be pushed or sucked into the designated container or pipeline; while in the preferred embodiment of the present application, the "reagent pre-installed" "concurrent micro-equivalent rapid liquid inlet technology" (such as applying flow paths Figures 21 - 24 , Figures 33 - 42 etc.) is used. The water sample and various reagents can be pre-fixed in volume in their respective branches at the same time, and then be driven by the pumps on each branch simultaneously or in sequence, or be driven by the pump in the main pipeline in sequence, and injected into the reaction vessel, greatly saving the total time for completing all reagent metering liquid inlet and subsequent cleaning.

[0027] Furthermore, the "sequential injection" type liquid inlet technology requires pumping the water sample or reagent into a metering tube for intermediate constant volume first, and then pumping the water sample or reagent in the metering tube into a predetermined container (such as a colorimetric tube). After the detection is completed, the discharge of the waste liquid also requires a reverse process. Such an operation is time-consuming and prone to increasing the risk of residual liquid in the flow path. In the preferred implementation of the present application, the flow path does not need to be provided with a liquid storage unit. The flow path schemes in each combined flow path can independently allow the liquid to be measured (such as a water sample) and the reagent to directly enter a colorimetric tube leading to the reaction container. The liquid feeding and volume metering can be completed simultaneously, and the liquid discharge is also simpler, only requiring continuous high-speed liquid discharge to the waste liquid port. Moreover, due to the improvement of the metering accuracy, the volume of the liquid introduced in the present application is greatly reduced, and the flow path travel is also greatly shortened. Therefore, compared with the traditional method, this will greatly shorten the liquid inlet time and improve work efficiency; and since the core components such as the plunger pump and the metering and quantitative tube are reduced, not only the cost is greatly reduced, but also the volume of the device can be reduced, realizing miniaturization and portability.

[0028] Other features and advantages of the present application will be described in detail in the subsequent specific implementation part. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The drawings are used to provide a further understanding of the present application and constitute a part of the specification. They are used together with the following specific implementation to explain the present application, but do not constitute a limitation to the present application. In the drawings:

[0030] Figures 1A to 1E And Figures 2 to 10 are respectively schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquids according to the present application.

[0031] Figures 11A to 11C is a schematic diagram of the A-type combined flow path of the device for quantitatively processing liquids according to the present application.

[0032] Figure 12 is a schematic diagram of the P-type combined flow path of the device for quantitatively processing liquids according to the present application.

[0033] Figures 13A to 13D is a schematic diagram of the B-type combined flow path of the device for quantitatively processing liquids according to the present application.

[0034] Figures 14A to 14C is a schematic diagram of the C-type combined flow path of the device for quantitatively processing liquids according to the present application.

[0035] Figures 15A to 15D is a schematic diagram of the BC-type combined flow path of the device for quantitatively processing liquids according to the present application.

[0036] Figures 16A to 16BSchematic diagram of the H-shaped combined flow path of the device for quantitatively processing liquids according to the present application.

[0037] Figures 17 to 43 Schematic diagrams of various reaction flow paths of the device for quantitatively processing liquids according to the present application, respectively.

[0038] Figure 44 Schematic diagram of the principle for expressing the technical advantages of the thin tube in the technical solution of the present application when in use. Detailed Description of the Invention

[0039] In the technical solution of the present application, emphasis is placed on describing the basic flow path of the device for quantitatively processing liquids, the combination of basic flow paths, and various application flow paths. It can be understood that in actual engineering applications, various liquid flow control methods can be achieved by combining the flow path scheme of the technical solution of the present application under the control of a computer system (such as a control unit like an industrial control computer or a single-chip microcomputer) for various components. The selection of the control unit and the program design can be made according to the actual working conditions.

[0040] As described above, the technical solution of the present application can be applied to various technical fields involving liquid processing and / or analysis, such as the medical field, the food field, and laboratory analysis, but is particularly applicable to water quality detection and analysis in the environmental protection field. For example, the technical solution of the present application is particularly applicable to water quality analyzers.

[0041] The following will describe the specific embodiments of the present application in detail with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are only for explaining and illustrating the present application and are not used to limit the present application.

[0042] I. Term Definitions

[0043] 1. Thin Tube

[0044] In the technical solution of the present application, the flow path adopts a thin tube design. The aperture of the thin tube is from 0.05 mm to 5 mm, preferably from 0.1 mm to 3 mm, more preferably from 0.2 mm to 2 mm, and even more preferably from 0.5 mm to 1.6 mm. In addition, throughout the flow path, the thin tube generally has a uniform aperture; however, within the allowable accuracy range or at the positions where components (such as peristaltic pumps or stop valves) are arranged, different apertures can also be designed.

[0045] The materials of the thin tube include but are not limited to various rubbers, plastics, or metals, etc. Commonly used tubes are silicone rubber tubes, fluororubber tubes, polytetrafluoroethylene tubes, etc.

[0046] In the technical solution of the present application, the reason for adopting the thin tube design is as follows.

[0047] As described above, by using a thin tube (combined with simple control of a peristaltic pump and / or a stop valve), not only can high-precision constant volume be achieved for a small liquid volume, but also high-precision micro liquid feeding (such as 0.1 - 2 milliliters) can be realized. For example, if a thin tube with a pore diameter of 0.5 mm and a length of 500 mm is selected for constant volume, the technical solution of the present application can easily achieve the constant volume measurement of about 100 microliters (0.1 milliliter) of sewage with an accuracy of up to ±2 microliters, and then convey the high-precision constant volume liquid out without residue. In addition, due to the use of a thin tube, it is possible to process and subsequently detect with a smaller volume of liquid sample, greatly reducing the cost of the reagents consumed.

[0048] More importantly, in the field of on-line monitoring under harsh working conditions, using the above-mentioned thin tube (the optimal choice for the inner diameter is 0.5 - 1.6 mm) also has three prominent advantages. First, it is relatively convenient to insert and remove the thin tube for maintenance, and the cost of regular replacement is also very low, which is particularly important for on-line monitoring instruments under harsh working conditions; second, for liquids that have been roughly filtered, such a pipe diameter can basically avoid pipeline blockage caused by possible suspended solids or impurities in the liquid, ensuring the stability of the flow path; third, when the conduit is thin enough, its inner diameter will be smaller than the liquid droplet height formed inside the conduit due to surface tension and wetting. At this time, the liquid will naturally converge and then seal the thin tube. Driven by the pump, the above liquid can be slowly fed into the target container, thus avoiding or reducing the amount of liquid retained or remaining in the pipeline that will affect the accuracy. If the aperture of the conduit is designed too large, after the liquid passes through the conduit, the liquid remaining on the inner wall of the pipeline is difficult to be removed by the gas blown in from the outside, because in this case, the maximum radial size of the liquid droplet of the remaining liquid is difficult to reach the height of the inner diameter of the pipeline. Therefore, even if gas is introduced, due to the existence of the above gap, it is difficult to more thoroughly remove the liquid remaining on the inner wall of the pipeline, as Figure 44 shown. In the technical solution of the present application, by selecting the above aperture size range of the thin tube, it is possible to make the maximum radial size of the liquid droplet finally formed by the liquid remaining on the inner wall of the pipeline reach or exceed the height of the inner diameter of the pipeline (as Figure 44 shown), so that the liquid or gas introduced can be used to more thoroughly remove the liquid remaining on the inner wall of the pipeline, and at the same time, it is possible to avoid the defect that the pipeline is easily blocked due to more impurities in the liquid to be measured in the field of on-line monitoring under harsh working conditions.

[0049] It can be understood that although the present application emphasizes the use of a thin tube, this does not mean excluding other non-thin tube devices that can form various complex combined channels in the present application. For example, the combined use of pipelines with a larger aperture can also be locally used with pipelines with a larger aperture without affecting the achievement of the invention purpose of the present application. For example, a thick constant volume tube is used when constant volume of a conventional volume exceeding 2 milliliters is required (see Figures 29 - 32) and a thick tube connected to the liquid discharge port for discharging waste liquid. This not only provides flexible wiring and low cost, but also facilitates maintenance during later use. Additionally, although the thin tube has been introduced above by taking the conduit as an example, it can be understood that on the premise of meeting the above-mentioned aperture size range, the thin tube in this application is not limited to the form of a conduit, and can also be other forms, such as an organic multi-way board, a microfluidic chip groove, etc.

[0050] 2. Peristaltic pump

[0051] In the technical solution of this application, the peristaltic pump is a generalized definition of a device or a combination of devices with peristaltic pump functions. Without special instructions, it generally refers to a device or a combination of devices that can drive liquid in both forward and reverse directions (sometimes only using its function of driving in a certain direction), and can cut off and close the pipeline when stationary. The above-mentioned generalized peristaltic pump includes but is not limited to the following specific devices or combinations of devices: a narrow sense peristaltic pump; a series combination of a shut-off valve and a pump (sometimes only using its function of driving in a certain direction) or a pump group (such as a combination composed of several diaphragm pumps, centrifugal pumps, etc.) that can drive fluid in both forward and reverse directions.

[0052] 3. Shut-off valve

[0053] In the technical solution of this application, the shut-off valve is a generalized definition of a device or a combination of devices with the function of being able to cut off and close a certain pipeline, including but not limited to the following specific devices: a diaphragm type two-way shut-off valve; a pinch type two-way shut-off valve (abbreviation: pinch valve); a peristaltic pump in a narrow sense (equivalent to closing when stationary and opening when rotating); a rotary switching type two-way or multi-way valve, etc.

[0054] 4. N-to-1 multi-channel valve (where N is a natural number greater than or equal to 2)

[0055] In the technical solution of this application, the N-to-1 multi-channel valve is a generalized definition of a device or a combination of devices. This device or combination of devices has a common port and N distribution ports. Through a control signal, the common port can be uniquely conducted to one of the N distribution ports or all not conducted. The above-mentioned generalized N-to-1 multi-channel valve includes but is not limited to the following specific devices or combinations of devices: a valve group formed by connecting N shut-off valves to the same common port; a multi-channel rotary switching valve (see Figure 35 ); other valve groups composed of multiple shut-off valves and multiple multi-channel switching valves, etc.

[0056] II. Basic flow path scheme

[0057] As Figures 1A to 1E and Figures 2 to 10 shown, the device provided in this application for quantitatively processing liquid (basic flow path scheme) includes:

[0058] Container P, which is used to hold the liquid to be extracted; and

[0059] A thin tube, which includes:

[0060] A flow-through pipeline 10, which extends outward from inside the container P to a bifurcation point a;

[0061] A first branch 11, which is communicated with the flow-through pipeline 10 and extends from the bifurcation point a to a first port K1; and

[0062] A second branch 12, which is communicated with the flow-through pipeline 10 and extends from the bifurcation point a to a second port K2;

[0063] Wherein, a peristaltic pump B1 is serially arranged in at least one of the flow-through pipeline 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is serially arranged in at least another one of the flow-through pipeline 10, the first branch 11 and the second branch 12, so as to be able to intercept a liquid with a predetermined volume between the bifurcation point a and the first port K1 or the second port K2. Wherein, the aperture of the thin tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.2 mm to 2 mm.

[0064] Container P is used to hold the liquid to be processed or analyzed. Container P can be made of various suitable materials, such as glass or plastic. The capacity of container P can be selected and designed according to specific working conditions. Usually, the maximum capacity of container P is 100 - 2000 ml. In addition, container P can be open, that is, communicated with the atmosphere; or it can be closed, that is, not directly communicated with the atmosphere. These two forms will be described in detail respectively in the following embodiments.

[0065] One end of the flow-through pipeline 10 is located inside the container P and extends outward to the bifurcation point a. From the bifurcation point a, the flow-through pipeline 10 is divided into a first branch 11 and a second branch 12. The first branch 11 has a first port K1, while the second branch 12 has a second port K2.

[0066] In order to accurately obtain the liquid sample to be processed or detected, a peristaltic pump B1 is serially arranged in at least one of the flow-through pipeline 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is serially arranged in at least another one of the flow-through pipeline 10, the first branch 11 and the second branch 12, so as to be able to intercept the liquid with a predetermined volume between the bifurcation point a and the first port K1 or the second port K2. Specifically, among the flow-through pipeline 10, the first branch 11 and the second branch 12, a peristaltic pump is serially arranged in at least one of them, and a stop valve or another peristaltic pump is arranged on at least another one of them. Among them, the peristaltic pump serves as the power source for sucking or pushing the liquid. When the peristaltic pump rotates and works, it can extract the liquid in the container P, and can also pump out the liquid after accurate volume determination; at the same time, when the peristaltic pump stops rotating, it can also be used for the function of cutoff. Therefore, by the cooperative work of the peristaltic pump and the stop valve, the liquid sample with a predetermined volume between the bifurcation point a and the first port K1 or the second port K2 can be accurately cutoff, so as to obtain an accurate acquisition of the liquid sample. In the following text, the interception process will be described in detail.

[0067] The technical solutions based on the innovative concept of the present application have many preferred implementation manners, mainly having various permutation and combination manners between the flow-through pipeline 10, the first branch 11, the second branch 12, the peristaltic pump and the stop valve. Specifically, among the flow-through pipeline 10, the first branch 11 and the second branch 12, any one of the peristaltic pump, the stop valve and no component setting (through pipe) can be selected, so there are a total of 3×3×3 = 27 combination manners. At the same time, the combination manners in which the flow-through pipeline 10, the first branch 11 and the second branch 12 are all stop valves or all no component settings need to be excluded (because the manners of all setting stop valves or all not setting components are not applicable), so there are a total of 25 combination manners. These combination manners are all within the scope of the present application.

[0068] In the following text, the structural composition, connection relationship, operation process and technical advantages will be described respectively in combination with each preferred implementation manner illustrated in the accompanying drawings.

[0069] Figures 1A to 1E and Figures 2 to 10 The various implementation manners of a single device have been mainly described. For the convenience of elaboration, the present application has stipulated the naming definitions of various basic flow paths in the follow-up. The name is divided into two parts, connected by a "-" sign in the middle. For example, "1A-basic type" represents Figure 1A the basic flow path shown, "2-basic type" represents Figure 2 the basic flow path shown, and so on. In addition, since Figures 1A to 1E the basic type has five variation forms (the principles are the same or relatively similar), so we use "1-basic type" to represent Figures 1A to 1EThe five basic flow paths shown are generally explained by taking "1A - basic type" as an example.

[0070] Next, the structural composition and connection relationship of each type of basic flow path will be described. For the sake of simplicity, only a part of the basic flow path is schematically drawn in the description of the basic type in this application.

[0071] As Figures 1A to 1E and Figures 2 to 6 shown, the basic flow path can have various connection forms.

[0072] For example Figure 1A and Figure 1B shown, the first peristaltic pump B1 is serially arranged in the first branch 11, the first stop valve F1 is serially arranged in the flow - through pipeline 10, and the second stop valve F2 or the second peristaltic pump B2 is serially arranged in the second branch 12.

[0073] For example Figure 1C and Figure 1D shown, the first peristaltic pump B1 is serially arranged in the first branch 11, the third peristaltic pump B3 is serially arranged in the flow - through pipeline 10, and the second peristaltic pump B2 or the second stop valve F2 is serially arranged in the second branch 12.

[0074] For example Figure 1E shown, the third peristaltic pump B3 is serially arranged in the flow - through pipeline 10, the first stop valve F1 is serially arranged in the first branch 11, and the second peristaltic pump B2 (not shown) or the second stop valve F2 is serially arranged in the second branch 12.

[0075] For example Figure 2 and Figure 3 shown, the first peristaltic pump B1 is serially arranged in the first branch 11, the flow - through pipeline 10 is a through - pipe, and the second stop valve F2 or the second peristaltic pump B2 is serially arranged in the second branch 12.

[0076] For example Figures 4 to 6 shown, the first branch 11 is a through - pipe, the second stop valve F2 or the second peristaltic pump B2 is serially arranged in the second branch 12, and the first peristaltic pump B1 is serially arranged in the flow - through pipeline 10.

[0077] Next, a more detailed description will be given to the basic flow paths shown in Figures 1A to 1E and Figures 2 to 10 as follows.

[0078] Embodiment 1

[0079] As Figures 1A to 1EAs shown, the structural composition and connection relationship of the device for quantitatively processing liquids are as follows.

[0080] Container P is used to hold the liquid to be extracted, and container P is a container communicating with the atmosphere. The flow path 10 of the thin tube extends out of container P from inside container P (preferably extending upward) and extends to the bifurcation point a. At this bifurcation point a, the flow path 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0081] In each of the flow path 10, the first branch 11 and the second branch 12, a peristaltic pump or a stop valve is serially arranged, and at least one of the flow path 10, the first branch 11 and the second branch 12 is serially arranged with a peristaltic pump. The following is an explanation of several different "1 - basic type" flow paths:

[0082] As Figure 1A shown in the "1A - basic type" basic flow path, a first stop valve F1 is serially arranged in the flow path 10, a first peristaltic pump B1 is serially arranged in the first branch 11, and a second stop valve F2 is serially arranged in the second branch 12.

[0083] Figure 1A The working process of the shown embodiment is as follows.

[0084] First, open the first stop valve F1 and keep the second stop valve F2 closed. Then rotate the first peristaltic pump B1 clockwise (based on the orientation shown in the figure, but not as a limitation to this application). At this time, the liquid in container P is drawn into the flow path 10 by the first peristaltic pump B1, passes through the first stop valve F1 and the first peristaltic pump B1, and then overflows and drains away through the first port K1.

[0085] Then, close the first stop valve F1, open the second stop valve F2, and rotate the first peristaltic pump B1 counterclockwise. Then, at this time, air enters from the first port K1, so that the liquid with a fixed volume in the tube between the bifurcation point a and the first port K1 can be taken out from the K2 port. Or, rotate the first peristaltic pump B1 clockwise, then air enters from the second port K2, so that the liquid with a fixed volume in the tube between the bifurcation point a and the first port k1 can be taken out from the first port K1.

[0086] As Figure 1B shown in the "1B - basic type" basic flow path, compared with Figure 1AThe main difference of the "1A - basic type" basic flow path shown is that the second stop valve F2 is replaced by the second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can function as a stop valve. With the liquid inlet operation process of the "1A - basic type" flow path, the liquid can be metered and fixed - volume in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with a fixed volume in a section of the pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be operated in the same direction but at different speeds to take out the above - mentioned liquid from the first port K1 or the second port K2. In this solution, the devices on the first branch 11 and the second branch 12 are preferably designed to be interchangeable, but they can also be different peristaltic pumps.

[0087] As Figure 1C shown, the main difference between the "1C - basic type" basic flow path and Figure 1A the "1A - basic type" basic flow path shown is that the first stop valve F1 is replaced by the third peristaltic pump B3. Therefore, when the third peristaltic pump B3 is stationary, it can function as a stop valve. With the liquid inlet operation process of the "1A - basic type" flow path, the liquid can be metered and fixed - volume in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with a fixed volume in a section of the pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the third peristaltic pump B3 can be operated in the same direction but at different speeds to take out the above - mentioned liquid from the first port K1 or the second port K2.

[0088] As Figure 1D shown, the main difference between the "1D - basic type" basic flow path and Figure 1A the "1A - basic type" basic flow path shown is that the first stop valve F1 and the second stop valve F2 are respectively replaced by the third peristaltic pump B3 and the second peristaltic pump B2. Therefore, when the second peristaltic pump B2 or the third peristaltic pump B3 is stationary, it can function as a stop valve. With the liquid inlet operation process of the "1A - basic type" flow path, the liquid can be metered and fixed - volume in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with a fixed volume in a section of the pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be operated in the same direction but at different speeds to take out the above - mentioned liquid from the first port K1 or the second port K2.

[0089] As Figure 1E shown, in the "1e - basic type" basic flow path, the third peristaltic pump B3 is serially arranged in the flow - through pipeline 10, the first stop valve F1 is serially arranged in the first branch 11, and the second stop valve F2 is serially arranged in the second branch 12.

[0090] Figure 1E The working process of the shown embodiment is described as follows.

[0091] First, open the first shut-off valve F1 and keep the second shut-off valve F2 closed. Then rotate the third peristaltic pump B3 counterclockwise (based on the orientation shown in the figure, but not as a limitation to this application). At this time, the liquid in the container P is drawn into the flow pipeline 10 by the third peristaltic pump B3, passes through the third peristaltic pump B3 and the first shut-off valve F1, and then overflows and drains through the first port K1.

[0092] Then, open the first shut-off valve F1, keep the first peristaltic pump B1 stationary, and open the second shut-off valve F2. At this time, air enters from the first port K1, and the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 is taken out from the second port K2 under the action of gravity. Similarly, due to the design of the thin pipe, when the third peristaltic pump B3 remains stationary and the second shut-off valve F2 is closed, the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 will not flow downward by itself, but will only flow out by itself under the action of gravity after the second shut-off valve F2 is opened.

[0093] From the above description, it can be seen that since the peristaltic pump has two rotational working conditions, it can be used to pump the liquid in the container P and also enable the liquid to be discharged from the corresponding port. The characteristics of the basic flow paths of each type in Figure 1 are as follows: on the three branches of the flow pipeline, the first branch, and the second branch, at least one peristaltic pump or shut-off valve must be connected in series on each branch, and there must be a branch with a peristaltic pump connected in series.

[0094] According to Figures 1A to 1E the shown implementation method, it is possible to extract a liquid sample of a predetermined volume with a relatively high working efficiency, and the accuracy of the volume of the obtained liquid sample is relatively high. Moreover, since the aperture of the thin pipe is small, the volume of the intercepted liquid sample is also relatively small. By adjusting the lengths of the first branch 11 and the second branch 12, the size of the liquid volume to be intercepted can be determined, and this method is also applicable in other implementation cases below.

[0095] Embodiment 2

[0096] As Figure 2 shown, the basic flow path structure composition and connection relationship of the device for quantitatively processing liquids are as follows.

[0097] The container P is used to hold the liquid to be extracted, and the container P is a container communicating with the atmosphere. The flow pipeline 10 of the thin pipe extends out of the container P from the inside of the container P (preferably extending upward) and extends to the bifurcation point a. At this bifurcation point a, the flow pipeline 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0098] As shown Figure 2 in the figure, no components are connected in series in the flow-through pipeline 10. A first peristaltic pump B1 is connected in series in the first branch 11, and a second stop valve F2 is connected in series in the second branch 12.

[0099] Figure 2 The working process of the shown embodiment is described as follows.

[0100] First, keep the second stop valve F2 closed, and then rotate the first peristaltic pump B1 clockwise (based on the orientation shown in the figure, but not as a limitation to this application). At this time, the liquid in the container P is drawn into the flow-through pipeline 10 by the first peristaltic pump B1, passes through the first peristaltic pump B1, and then overflows and drains through the first port K1.

[0101] Then, keep the first peristaltic pump B1 stationary (equivalent to a cut-off state), and open the second stop valve F2. At this time, air enters from the second port K2, so that the liquid between the bifurcation point a and the container P flows back into the container P under the action of gravity, while the liquid with a fixed volume in the pipe between the bifurcation point a and the first port k1 remains stationary due to the cut-off of the peristaltic pump B1 and the surface tension and non-expandability of the liquid.

[0102] Subsequently, rotate the first peristaltic pump B1 clockwise. Since the resistance at the second port K2 is slightly greater than the gravity that the liquid in the conduit in the container P has to overcome when rising, air enters from the second port K2, and then the liquid with a fixed volume in the pipe between the bifurcation point a and the first port k1 is taken out from the first port K1.

[0103] From the above description, it can be seen that by utilizing the pore size characteristics of the thin pipe and combining the physical effects of gravity, the non-expandability and surface tension of the liquid, the technical solution of this application can be realized at a relatively low cost.

[0104] Embodiment 3

[0105] As Figure 3 shown in the third preferred embodiment, the main difference from the second embodiment shown Figure 2 in the figure is that the second stop valve F2 is replaced by a second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can play a cut-off role. When it is necessary to take out the liquid with a fixed volume in the pipe between the bifurcation point a and the first port k1, the first peristaltic pump B1 and the second peristaltic pump B2 can be rotated in the same direction but at different speeds to take out the above liquid from the first port K1 or the second port K2.

[0106] Embodiment 4

[0107] As Figure 4As shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0108] Container P is used to hold the liquid to be extracted, and the container P is a container communicating with the atmosphere. The flow passage 10 of the thin tube extends out of the container P from the inside of the container P (preferably extending upward), and extends to the bifurcation point a. At this bifurcation point a, the flow passage 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0109] As Figure 4 shown, a first peristaltic pump B1 is serially arranged in the flow passage 10, no device is serially arranged in the first branch 11, and a second peristaltic pump B2 is serially arranged in the second branch 12.

[0110] Figure 4 The working process of the shown embodiment is as follows.

[0111] First, keep the second peristaltic pump B2 stationary, and then make the first peristaltic pump B1 rotate counterclockwise (based on the orientation shown in the figure, but not as a limitation to this application). At this time, the liquid in the container P is drawn into the flow passage 10 by the first peristaltic pump B1, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows and drains through the first port K1.

[0112] Then, keep the first peristaltic pump B1 stationary (equivalent to the cut-off state), and the second peristaltic pump B2 rotates counterclockwise. Then, at this time, air enters from the first port K1, so that the liquid with a fixed volume in the tube between the bifurcation point a and the first port k1 is taken out from the second port K2. Or, if the second peristaltic pump B2 rotates clockwise, air enters from the second port K2, so that the liquid with a fixed volume in the tube between the bifurcation point a and the first port k1 is taken out from the first port K1.

[0113] It can be seen from the above description that the stationary cut-off working conditions and the bidirectional rotation working conditions of the two peristaltic pumps can be used to intercept the liquid sample of the predetermined section from the first port K1 or the second port K2 as needed.

[0114] Embodiments 5 and 6

[0115] As Figure 5 and Figure 6 shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0116] Container P is used to hold the liquid to be extracted, and the container P is a container communicating with the atmosphere.

[0117] The flow-through pipeline 10 of the thin tube extends out of the container P from inside the container P (preferably extending upward), and extends to the bifurcation point a.

[0118] At this bifurcation point a, the flow-through pipeline 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2. The first branch 11 is a pipeline that extends obliquely from the bifurcation point a to the first port K1, extending either obliquely upward or obliquely downward. The inclination angle of this inclined pipeline relative to the horizontal plane can be selected and designed according to specific application conditions, such as between 30 degrees and 90 degrees, or preferably about 45 degrees.

[0119] As Figure 5 and Figure 6 shown, a first peristaltic pump B1 is serially arranged in the flow-through pipeline 10, no components are serially arranged in the first branch 11, and a second stop valve F2 is serially arranged in the second branch 12.

[0120] Figure 5 and Figure 6 The working process of the embodiment shown is as described below.

[0121] First, keep the second stop valve F2 closed. Then make the first peristaltic pump B1 rotate counterclockwise (based on the orientation shown in the figure, but not as a limitation to this application). At this time, the liquid in the container P is drawn into the flow-through pipeline 10 by the first peristaltic pump B1, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows and drains through the first port K1.

[0122] Then, in Figure 5 the working condition shown, the first peristaltic pump B1 remains stationary and the second stop valve F2 is opened. At this time, air enters from the second port K2, and the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 flows out from the first port K1 under the action of gravity. In this case, due to the design of the thin tube, when the first peristaltic pump B1 remains stationary and the second stop valve F2 is closed, the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 will not flow downward by itself, but will flow out by itself under the action of gravity only when the second stop valve F2 is opened.

[0123] And in Figure 6In the described operating condition, the first peristaltic pump B1 remains stationary and the second stop valve F2 is opened. At this time, air enters from the first port K1, and the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 flows out from the second port K2 under the action of gravity. Similarly, due to the design of the thin pipe, when the first peristaltic pump B1 remains stationary and the second stop valve F2 is closed, the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 will not flow downward by itself, but will only flow out by itself under the action of gravity after the second stop valve F2 is opened.

[0124] As can be seen from the above description, simply using the static cut-off function of the peristaltic pump, the inclined design of the branch, and the design of the thin pipe, it is possible to conveniently intercept and collect liquid samples with accurate volumes by using gravity.

[0125] The above various embodiments do not exhaust all the combination relationships under the technical solutions of the present application. For example, in different embodiments, when there are no flow path devices provided, the branch and the flow-through pipeline can be formed in the form of a through pipe. In some of the above embodiments, the flow-through pipeline 10 can be designed as a through pipe; while in other embodiments, the first branch 11 and / or the second branch can be designed as a through pipe. The working process of the embodiments not listed in the accompanying drawings of the specification of the present application can naturally refer to the detailed descriptions of the structures and working processes of the above various embodiments.

[0126] In each of the above embodiments, the container P is a container communicating with the atmosphere. However, in some operating conditions with more stringent requirements for strong corrosive reagents, volatile reagents, or water samples, the container P is designed as a closed container not directly communicating with the atmosphere, as Figures 7 to 10 shown. Such a closed container can be obtained by first injecting liquid into the container and then sealing it. The closed container is connected with a pressurizing device for increasing the air pressure inside the container, and the flow-through pipeline 10 extends out of the container P from inside the container P. The following will be described in detail Figures 7 to 10 in this regard.

[0127] Embodiment 7

[0128] As Figure 7 shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0129] The container P is used to hold the liquid to be extracted, and the container P is a closed container not directly communicating with the atmosphere.

[0130] The flow-through pipeline 10 of the thin tube extends out of the container P from inside the container P (preferably extending upward) and extends to the bifurcation point a. At this bifurcation point a, the flow-through pipeline 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0131] As Figure 7 shown, a first stop valve F1 is serially arranged in the flow-through pipeline 10, a second stop valve F2 is serially arranged in the first branch 11, and a third peristaltic pump B3 is serially arranged in the second branch 12.

[0132] Figure 7 The working process of the shown embodiment is as described below.

[0133] First, the first stop valve F1 is opened and the second stop valve F2 is closed. The third peristaltic pump B3 rotates clockwise, so that air enters the container P from the second port K2 through the first stop valve F1 for pressurization. Therefore, at this time, the third peristaltic pump B3 functions as a pressurizing device.

[0134] Then, the first stop valve F1 is first closed and the third peristaltic pump B3 is kept stationary (stopped). Then the first stop valve F1 and the second stop valve F2 are opened. At this time, the liquid in the container P will enter the flow-through pipeline 10 under the action of the internal pressure, and then overflow and drain through the first stop valve F1 and the second stop valve F2 through the first port K1.

[0135] Subsequently, the first stop valve F1 is closed again, and the third peristaltic pump B3 is rotated clockwise, then air enters from the second port K2, and the liquid with a fixed volume in the pipeline between the bifurcation point a and the first port k1 is pushed out through the first port K1. Or, the third peristaltic pump B3 is rotated counterclockwise, then air enters from the first port K1, and the liquid with a fixed volume in the pipeline between the bifurcation point a and the first port k1 is pushed out through the second port K2.

[0136] Embodiment 8

[0137] As Figure 8 shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0138] The container P is used to hold the liquid to be extracted, and the container P is a closed container that is not directly connected to the atmosphere. The pressurizing device is a heater 30 arranged in the container, and this heater is used to heat the air in the container.

[0139] The flow-through pipeline 10 of the thin pipe extends out of the container P from inside the container P (preferably extending upward) and extends to the bifurcation point a. At this bifurcation point a, the flow-through pipeline 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0140] As Figure 8 shown, a first stop valve F1 is serially arranged in the flow-through pipeline 10, no components are serially arranged in the first branch 11, and a third peristaltic pump B3 is serially arranged in the second branch 12.

[0141] Figure 8 The working process of the shown embodiment is as described below.

[0142] First, the first stop valve F1 is opened and the third peristaltic pump B3 is stationary. The heater 30 heats and pressurizes the air in the container P. At this time, the liquid in the container P will enter the flow-through pipeline 10 under the action of the internal pressure, and then overflow and drain through the first stop valve F1 and the bifurcation point a and through the first port K1.

[0143] Subsequently, the first stop valve F1 is closed, and the third peristaltic pump B3 is rotated clockwise. Then air enters from the second port K2, and the liquid with a fixed volume in the pipe between the bifurcation point a and the first port k1 is pushed out through the first port K1. Or, the third peristaltic pump B3 is rotated counterclockwise, then air enters from the first port K1, and the liquid with a fixed volume in the pipe between the bifurcation point a and the first port K1 is pushed out through the second port K2.

[0144] In this embodiment, a cooler is preferably provided. When a liquid sample with a predetermined volume is intercepted, the air in the container P can be cooled to enable the liquid between the bifurcation point a and the port 101 of the flow-through pipeline 10 to flow back into the container P, thus facilitating the next liquid extraction operation.

[0145] Embodiments 9 and 10

[0146] See Figure 9 and Figure 10 The main difference between the shown Embodiment IX and Figure 8 the shown Embodiment VIII lies in the pressurizing device.

[0147] In Embodiment X, as Figure 10 shown, the pressurizing device includes a fourth peristaltic pump B4, and the liquid container P is directly communicated with the external atmosphere through this fourth peristaltic pump B4. While in Embodiment IX, as Figure 9As shown, the fourth peristaltic pump B4 can be connected to another auxiliary container P2 (containing the same liquid) that communicates with the atmosphere to pump the liquid in the auxiliary container P2 into the container P to achieve pressurization.

[0148] For the working processes of other operations of intercepting a predetermined volume of liquid sample in a fixed volume, reference can be made to Embodiment 8.

[0149] The above various embodiments do not exhaust all the combinatorial relationships under the technical solutions of this application. For example, a peristaltic pump may also be serially arranged in the flow-through pipeline 10, and a peristaltic pump or a stop valve may be serially arranged in the second branch or the first branch. The peristaltic pump cooperates with the stop valve and the pressurizing device to enable the liquid sample with a predetermined volume between the bifurcation point a and the first port K1 to flow out of the first port K1 or the second port K2.

[0150] The above describes the embodiments of the closed container, and the above various embodiments can be selected and applied according to specific working conditions.

[0151] In addition, as shown in the figure, in a preferred case, a liquid detector S is provided at a position of the first branch 11 adjacent to the first port K1. The liquid with a predetermined volume between the bifurcation point a and the first port K1 is the liquid between the bifurcation point a and the liquid detector S. The liquid detector S can be various sensors suitable for judging the presence of liquid to judge whether there is liquid or the liquid reaches the position where the liquid detector S is located.

[0152] By providing the liquid detector S, it is not necessary to determine the volume capacity by making the liquid flow out of the first port K1. That is to say, in the embodiments provided with the liquid detector S, a more flexible volume of liquid sample near the liquid detector S from the bifurcation point a can be intercepted. At the same time, since there is no need for liquid overflow, waste can be prevented. Further preferably, the liquid between the bifurcation point a and the liquid detector S is the liquid from the bifurcation point a to a predetermined offset point based on the liquid detector S. The distance of the predetermined offset point can be controlled by an algorithm for liquid inflow in the flow path (for example, related to the flowing speed of the liquid, or related to whether there are bubbles in the liquid, or the length and volume of the bubbles), so as to perform error compensation on various uncertain factors (bubbles, liquid flow speed, pulsating liquid inlet error when the peristaltic pump feeds liquid, etc.) during liquid inlet to obtain a more accurate liquid sample with a predetermined volume. It can be understood that in the technical solutions of this application, a liquid detector S can also be provided at a position of the second branch 12 adjacent to its second port K2. It can be understood that the technical features of the liquid detector S can be applied to various basic flow paths in this application, and are not limited to the embodiments illustrated in the accompanying drawings of this application specification.

[0153] Preferably, an extension section (not shown) extending downward is provided at the first port K1, preferably extending vertically downward, so as to ensure that when the liquid overflows at the outlet of the capillary tube, the interference of uncertain factors on the volume quantitative interception is avoided, and the accuracy of constant volume is further improved.

[0154] Figures 1A to 1E and Figures 2 to 10 The various embodiments of the basic flow path have been mainly described. According to a further preferred embodiment, a single basic flow path can be appropriately arranged and combined to be applicable to the working occasions of multiple containers P containing the same or different liquids. The combined device scheme formed by the combination of a single basic flow path will be described in detail below.

[0155] In addition, it can be understood that the main advantage of the above basic flow path compared with the traditional technology is that the flow path scheme using a capillary tube combined with a peristaltic pump and / or a stop valve can achieve high-precision constant volume and push it out, and has high working efficiency, very low cost and can be flexibly combined (series, serial or parallel, parallel).

[0156] III. Combined Flow Path Solutions

[0157] As described above, each basic flow path includes five elements: a first port K1, a second port K2, a first branch 11, a second branch 12, and a bifurcation point a. According to different working conditions and liquid inlet requirements, the above various types of basic flow paths can be combined differently to obtain different combined flow path schemes.

[0158] For the convenience of description, this application stipulates the naming definitions of various access methods for connecting various basic flow paths to the main flow branch. The name is divided into three parts, connected by a "-" sign in the middle, such as the "1-K1-B" type. The specific naming definitions are as follows:

[0159] The first part of the name indicates the basic flow path used. For example, if the basic flow path of Figures 1A to 1E one of them is used, the name of this part is "1". If the basic flow path of Figure 2 is used, the name of this part is "2", and so on; it should be noted that since there are five variants of the basic flow path in Figure 1, but their principles are the same, so we use the "1A-basic type" flow path as an example. In the combined flow path, generally we uniformly use "1" for unified naming, unless special instructions are required.

[0160] The second part of the name identifies the access point of the basic flow path and the main flow branch. For example, if the access point is the first port K1, the name of this part is "K1"; if the access point is the second port K2, the name of this part is "K2"; if the access point is the bifurcation point a, the name of this part is "a". And so on.

[0161] The third part of the name identifies how each type of basic flow path is merged to connect to the main stream branch. The different merging methods are defined as follows:

[0162] Type A means that each type of basic flow path is independent and connected to the main flow branch in parallel, marked as "A". Figure 11A and Figure 11B As shown, Figure 11C Only one basic flow path is shown as an example, but it can be understood that multiple basic flow paths can be connected in parallel;

[0163] P type means that each type of combined flow path is independent and connected to the main flow branch in parallel, but a peristaltic pump B is required on the main flow branch to better drive fluid metering and liquid inlet. This type of combined flow path is marked as "P", such as Figure 12 As shown;

[0164] Type B means that the first branches 11 of the same or different basic flow paths are combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "B", such as Figures 13A to 13D As shown;

[0165] Type C indicates that the second branches 12 of the same or different basic flow paths are combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "C". Figures 14A to 14C As shown;

[0166] BC type means that the first branch 11 of the same or different basic flow paths are combined and shared, and the second branch 12 is also combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "BC", such as Figures 15A to 15D As shown;

[0167] Type H indicates that the bifurcation point a of each type of basic flow path is merged and shared, and is directly connected to the main flow branch through point a. A peristaltic pump or stop valve is connected in series on the main flow branch; or, one or several first branches or second branches in the basic flow path are directly used as the main flow branch; this type of combined flow path is marked as "H", as shown in Figure 16.

[0168] It should be noted that the so-called A, B, C, BC, P, H, etc. are named only to distinguish different types of flow path solutions and do not constitute a limitation on the scope of protection of this application. The above flow path solution naming method also applies to the flow path solutions shown in other figures of this application.

[0169] It should be noted that in all types of combined flow paths, the bifurcation point a can physically exist as either a point or a section of the flow path. At the same time, to more conveniently and concisely display the topological structure of each combined flow path accessing the main trunk branch, in this application, the main trunk branches in each figure are segmented (into three lines) and displayed separately. It should be noted that these main trunk branches can also be composed of a connected main trunk branch as needed.

[0170] Next, the structural composition and connection relationships of each type of combined flow path will be described. For the sake of simplicity, in this application, only 1 or 2 basic flow paths are schematically drawn for some combined flow paths. It should be noted that in actual application, there can be designs with more basic flow paths. In addition, in the combined flow path scheme, the main trunk branch can be one or more. All these deformation forms are within the protection scope of this application.

[0171] 3.1A - type Combined Flow Path:

[0172] The definition of the A-type combined flow path is as follows: Each basic flow path is independent and is connected to a certain higher-level main trunk branch through its first port K1 or second port K2, thereby forming a combined flow path that can perform parallel liquid inlet (or can also be used for liquid discharge). One port of this main trunk branch is closed, and the other port serves as the common outlet for transporting liquid for each basic flow path, as Figures 11A to 11C shown.

[0173] Figures 11A - 11C lists some combined forms in which the basic flow paths shown in FIGS. 1 to Figure 6 are connected in parallel to the same main trunk branch.

[0174] For example, "1-K1-A type" means that the basic flow path in FIG. 1 accesses the main trunk branch through the first port K1, "1-K2-A type" means that the basic flow path in FIG. 1 accesses the main trunk branch through the second port K2, and "2-K1-A type" means that Figure 2 the basic flow path in accesses the main trunk branch through the first port K1, and so on.

[0175] Again, for example, as Figures 11A to 11C shown, the first port K1 of one of the basic flow paths shown, Figures 1A to 1E the second port K2 of one of the basic flow paths shown, and Figures 1A to 1E the first port K1 of the basic flow path shown can be independently connected to the same main trunk flow path; or the first port K1 (or second port K2) of the basic flow path shown, Figure 2 the first port K1 of the basic flow path shown, and Figure 3 the second port K2 of the basic flow path shown can be connected to the same main trunk flow path; or alternatively, Figure 4 the first port K1 of the basic flow path shown, Figure 4 and the second port K2 of the basic flow path shown can be connected to the same main trunk flow path; or one can also chooseFigure 6 The second port K2 of the shown basic flow path and the first port or the second port (not shown) of other basic flow paths are connected to the same main trunk flow path. Each of the above basic flow paths can independently feed liquid according to the aforementioned metering liquid feeding steps.

[0176] Meanwhile, liquid detectors S are installed on the branch pipes connecting to the main trunk branch in "Type 1-K1-A", "Type 2-K1-A", "Type 3-K1-A", "Type 3-K2-A", "Type 4-K1-A", and "Type 6-K2-A" for metering positioning or detecting whether the liquid reaches the detection position, ensuring that the liquid does not enter the main trunk branch according to the working conditions during metering.

[0177] It can be understood that in Figures 11A to 11C the combined flow path scheme shown is only Figures 1A to 1E and Figures 2 to 6 a part of all possibilities of the permutations and combinations of the basic flow paths shown. The protection scope of this application covers all forms of its permutations and combinations. For example, N basic flow paths can be connected to the same main trunk flow path, where N is a natural number greater than or equal to 1, and each basic flow path can choose its own feasible first port K1 or second port K2 to access the same main trunk flow path. It can also be understood that the basic flow path is not limited to the basic flow path scheme shown in FIGS. 1 to Figure 6 shown, and the basic flow path scheme shown in <http: / / www.example.com / Figures 7 to 10 shown can also be selected.

[0178] It can be understood that as described above, although this application emphasizes the use of thin tubes, this does not mean excluding other non-thin tube devices that can form various complex combined channels in this application. Without affecting the achievement of the invention purpose of this application, pipelines with larger apertures can also be locally adopted. For example, as Figure 11C shown, when it is necessary to volumetrically fix a conventional volume exceeding, for example, 2 milliliters, the first branch 11 of "Type 6-K2-A" can adopt a thick volumetric fixing tube to increase the liquid feeding or discharging speed, thereby improving the overall processing or detection speed of the device.

[0179] The beneficial effect of the A-type combined flow path is that the water samples or reagents connected by each basic flow path can be fed and metered simultaneously in parallel, and this performance can greatly improve the overall processing efficiency or detection speed of the device.

[0180] 3.2P - type Combined Flow Path

[0181] Preferably, in order to more conveniently realize the flow of the liquid, at least one peristaltic pump B can be arranged on the main trunk flow path of the A-type combined flow path, as Figure 12 shown. This type of combined flow path is named "P-type combined flow path" in this application.

[0182] Figure 12Two combined flow paths of "5-K2-P type" and "6-K2-P type" are listed. Due to the peristaltic pump B on the main flow path, the fluid can flow in the basic flow path not only by gravity or the drive of other pumps, but also the movement control of the liquid can be better achieved by using the peristaltic pump B on the main flow path. It can be understood that Figure 12 This is only an exemplary representation. Other basic flow paths with different quantities can also be selected, and each basic flow path can choose its own first port K1 or second port K2 to access the same main flow path. At this time, the peristaltic pump B in the P-type main flow path needs to cooperate with the respective peristaltic pumps and stop valves in the basic flow paths so as to better transport the liquid in the flow path according to the set requirements.

[0183] 3.3B - type Combined Flow Path:

[0184] The definition of the B-type combined flow path is: the first branches 11 of the same type of basic flow paths are merged and shared, and then access a certain higher-level main branch through the merged and shared first port K1 or the separately independent second port K2 (K2'), thus forming a combined flow path that can feed liquid in parallel (can also be used for draining liquid). One port of this main branch is closed, and the other port is used as the common outlet for transporting the liquid of each B-type combined flow path, as Figures 13A to 13D shown.

[0185] Figures 13A to 13D lists the combination forms in which each basic flow path shown in Figures 1A to 1E and Figures 2 to 6 is combined according to the above rules and then connected in parallel to the same main branch through the first port K1 or the second port K2.

[0186] For example, "1-K1-B type" means the basic flow path in Figures 1A - 1E where its first branch 11 is merged and shared, and then accesses the main branch through the first port K1; "1-K2-B type" refers to the basic flow path in Figures 1A - 1E where its first branch 11 is merged and shared, and then accesses the main branch through the second port K2; "4-K1-B type" means the basic flow path in Figure 4 where its first branch 11 is merged and shared, and then accesses the main branch through the first port K1; "4-K2-B type" refers to the basic flow path in Figure 4 where its first branch 11 is merged and shared, and then accesses the main branch through the second port K2; "6-K2-B type" refers to the basic flow path in Figure 6 where its first branch 11 is merged and shared, and then accesses the main branch through the second port K2; and so on.

[0187] Each of the above-mentioned basic flow paths can feed liquid according to the aforementioned metering liquid inlet principle and steps. However, when one of the flow paths is working, except for the devices on the first branch 11 that work together, the devices on other basic flow paths should be in a stationary state (the peristaltic pump is stationary and the stop valve is closed), which will not be elaborated here again.

[0188] Preferably, a liquid detector S can be installed on the branch pipe connecting each B-type combined flow path to the main stream branch for metering positioning or detecting whether the liquid reaches the detection position, so as to ensure that the liquid will not enter the main stream branch during metering according to the working conditions.

[0189] It can be understood that the combined flow path scheme shown in Figures 13A to 13D is only an implementation manner formed by combining the basic flow paths shown in part of the diagrams according to the B-type combined flow path. It can be understood that this application is not limited to this, and the protection scope of this application covers all permutations and combinations of various basic flow paths. For example, the basic flow paths used to implement the combined flow path are not limited to Figures 1A - 1E and Figures 2 to 6 the basic flow path schemes shown, and the basic flow path scheme shown in Figures 7 to 10 can also be selected, or the basic flow path scheme not shown in the diagrams can be selected.

[0190] Compared with the A-type and P-type combined flow paths, the beneficial effect of the B-type combined flow path is that the number of peristaltic pumps or stop valves is reduced, and accordingly the cost is saved and the stability is improved.

[0191] 3.4C - type Combined Flow Path:

[0192] The definition of the C-type combined flow path is: the second branches 12 of the same type of basic flow paths are merged and shared, and then connected to a certain higher-level main stream branch through the independent first ports K1 (K1') or the merged and shared second port K2, so as to form a combined flow path that can feed liquid separately (or can also be used for draining liquid). One port of the main stream branch is closed, and the other port is used as the common outlet for transporting liquid of each C-type combined flow path, as shown in Figures 14A to 14C shown.

[0193] Figures 14A to 14C lists the combined forms in which the basic flow paths shown in Figures 1A - 1E and Figures 2 to 6 are merged and combined according to the above rules and then connected in parallel to the same main stream branch through the first port K1 or the second port K2.

[0194] For example, "1-K1-C type" means the basic flow path in Figure 1, whose second branch 12 is merged and shared, and then connected to the main stream branch through the first port K1; "1-K2-C type" refers to Figure 1AIn the basic flow path, the second branch 12 is merged and shared, and then accesses the main flow branch through the second port K2; "4-K2-C type" means Figure 4 In the basic flow path, the second branch 12 is merged and shared, and then accesses the main flow branch through the second port K2; and so on.

[0195] Each of the above basic flow paths can feed liquid according to the aforementioned metering liquid feeding principle and steps. However, when one of the flow paths is working, except for the devices on the first branch 11 that cooperate with it, the devices on other basic flow paths should be in a stationary state (the peristaltic pump is stationary and the stop valve is closed). This will not be elaborated here.

[0196] At the same time, a liquid detector S can be installed on the branch pipe where each C-type combined flow path is connected to the main flow branch, for metering and positioning, or for detecting whether the liquid reaches the detection position, to ensure that the liquid does not enter the main flow branch according to the working conditions during metering.

[0197] It can be understood that in Figures 14A to 14C the combined flow path scheme shown is only Figures 1A - 1E and Figures 2 to 6 a part of the most practical and feasible flow path formed by combining the basic flow paths shown according to the C-type combined flow path. The protection scope of this application covers all permutation and combination forms thereof. For example, the basic flow paths used to implement the combined flow path are not limited to Figures 1A - 1E and Figures 2 to 6 the basic flow path schemes shown, and the basic flow path scheme shown in Figures 7 to 10 can also be selected, or the basic flow path scheme not shown in the figure can also be selected.

[0198] It should be noted that the "1-K1-C type" combined flow path has two or more access points to the main flow branch: K1 and K1'. The above two points can be different positions on the same main flow branch (such as Figures 14A to 14C shown), or can be distributed to access different main flow branches (not shown).

[0199] Compared with the A-type and P-type combined flow paths, the beneficial effect of the C-type combined flow path is to reduce the number of peristaltic pumps or stop valves, thereby saving costs and improving stability.

[0200] 3.5BC - type Combined Flow Path:

[0201] The definition of the BC-type combined flow path is as follows: the first branch 11 and the second branch 12 of the same-type basic flow path are respectively merged and shared, and then connected to a certain higher-level main flow branch through the merged and shared first port K1 or the merged and shared second port K2, thereby forming a combined flow path that can feed liquid separately (and can also be used for draining liquid). One port of this main flow branch is closed, and the other port is used as the common outlet for transporting liquid of each BC-type combined flow path, as Figures 15A to 15D shown.

[0202] Figures 15A to 15D lists the combined forms in which each basic flow path shown in Figures 1A - 1E and Figures 2 to 6 is merged and combined according to the above rules, and then connected in parallel to the same main flow branch through the first port K1 or the second port K2.

[0203] For example, "1-K1-BC type" means Figures 1A - 1E one of the basic flow paths, where the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the first port K1; "1-K2-BC type" refers to the basic flow path in Figure 1, where the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the second port K2; "4-K1-BC type" means Figure 4 the basic flow path in which, the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the first port K1; "4-K2-BC type" refers to Figure 4 the basic flow path in which, the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the second port K2; "6-K2-BC type" refers to Figure 6 the basic flow path in which, the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the second port K2; and so on.

[0204] Among them, Figures 15A to 15C the combined flow path shown is a combination of two different types of variants of "1-basic type", and the devices connected in series in the flow pipeline are a peristaltic pump and a stop valve respectively, and their stopping effects are the same.

[0205] Each of the above basic flow paths can feed liquid according to the aforementioned metering liquid feeding principle and steps. Only when one of the flow pipelines is working, except for the devices on the first branch 11 that cooperate with each other, the devices on other basic flow paths should be in a static state (the peristaltic pump is static and the stop valve is closed). This will not be elaborated here.

[0206] Meanwhile, a liquid detector S may be installed on the branch pipe connecting each BC-type combined flow path to the main flow branch for metering and positioning, or for detecting whether the liquid has reached the detection position, ensuring that the liquid does not enter the main flow branch according to the working conditions during metering.

[0207] It can be understood that the combined flow path scheme shown in Figures 15A to 15D is only an implementation manner formed by combining the basic flow paths shown in Figures 1A - 1E and Figures 2 to 6 in the BC-type combined flow path. The protection scope of this application covers all permutation and combination forms thereof. It can also be understood that, for example, the basic flow paths used to implement the combined flow path are not limited to the basic flow path schemes shown in Figures 1A - 1E and Figures 2 to 6 . The basic flow path scheme shown in Figures 7 to 10 can also be selected, or the basic flow path scheme not shown in the figure can also be selected.

[0208] Compared with the A-type, P-type, B-type, and C-type combined flow paths, the beneficial effect of the BC-type combined flow path is that it more effectively reduces the number of peristaltic pumps or stop valves, correspondingly saves costs, and improves stability.

[0209] 3.5H - type Combined Flow Path:

[0210] The definition of the H-type combined flow path is as follows: the bifurcation points a of each type of basic flow path are merged and shared, and directly access the main flow branch through point a. A peristaltic pump or a stop valve is connected in series on this main flow branch; alternatively, one or several of the first branches or the second branches in the basic flow path are directly used as the main flow branch. In the H-type combined flow path, a peristaltic pump or a stop valve is connected in series on all the flow-through branches, the first branches 11, and the second branches 12 of the basic flow path, and there must be at least one peristaltic pump. Among them, in all the above-mentioned first branches 11 and second branches 12, some of the first branches 11 or second branches 12 are used as constant-volume metering conduits, and the other first branches 11 or second branches 12 or the aforementioned main flow branch can be used as the outlet for transporting the liquid, as shown in Fig. 16. Through the above combination rules, multiple combined flow paths that can be flexibly combined for liquid inlet (can also be used for liquid discharge) can be formed.

[0211] Figure 16A Fig. 17 shows two H-type combined flow paths, both of which adopt the basic flow path of Fig. 1 and the bifurcation point a is used in combination. The difference is that a peristaltic pump is connected in series on the main flow branch of the left flow path, and a stop valve is connected in series on the main flow branch of the right flow path.

[0212] Figure 16B Fig. 18 shows a more complex H-type combined flow path. Except for the three flow-through branches below, each branch above can be used as a constant-volume metering tube or a liquid output outlet.

[0213] Each of the above-mentioned basic flow paths can feed liquid according to the aforementioned metering liquid-feeding principle and steps. However, when one of the flow-through pipelines is working, except for the devices on a certain first branch 11 or a certain second branch that cooperate with it, the devices on other basic flow paths should be in a static state (the peristaltic pump is static and the stop valve is closed). This will not be elaborated here.

[0214] Compared with the A, P, B, C, and BC-type combined flow paths, the greatest advantage of the H-type combined flow path is its flexible combination. With the fewest devices, liquid can be metered in fixed volumes according to different specifications and then transported to different ports (such as multiple reaction vessels) for subsequent processing.

[0215] The above has described in detail various combination schemes of the basic flow paths of this application. During operation, the liquid in each container can be intercepted in predetermined volume segments separately, either simultaneously or by selectively choosing one or several containers. Finally, it is pushed out from the selected ports in sequence or simultaneously. Therefore, the various combination schemes of the above basic flow paths can intercept high-precision quantitative liquid for the liquids in multiple different containers separately, simultaneously, or in a predetermined order, and transport the quantitatively intercepted high-precision liquid. Moreover, due to the combination of the basic flow paths, the use of components can be greatly reduced, thereby reducing the overall cost.

[0216] In addition, as described above, Figures 11A to 11C and Figures 12 to 16A and Figure 16B exemplarily shows various types of combined flow path schemes based on the basic flow path. The basic flow path used to implement the combined flow path is not limited to Figures 1A to 1E and Figures 2 to 6 the basic flow path scheme shown, and the basic flow path scheme shown in Figures 7 to 10 can also be selected, or the basic flow path scheme not shown in the figure can be selected. All possible combination methods of these basic flow paths are within the scope of this application.

[0217] In addition, it should be noted that various liquid-feeding and / or liquid-discharging in the above various combined flow paths can be implemented according to the liquid-feeding and / or liquid-discharging methods of various types of basic flow paths. Therefore, these variation forms are all within the scope of this application.

[0218] IV. Application Flow Path Solutions

[0219] In the application flow path scheme, it includes a (reaction) vessel 100, which is used for reaction processing and / or detection and analysis, and has a top opening at the top and / or a bottom opening at the bottom.

[0220] In order to inject a required predetermined liquid sample (intercepting an accurate volume) into the vessel 100 for reaction processing and / or detection and analysis, the above-mentioned basic flow path scheme and / or combined flow path scheme can be connected to the vessel 100. According to different application conditions, it can be connected to the vessel 100 through an opening at the bottom, or it can be connected to the vessel 100 through an opening at the bottom and an opening at the top, or it can also be connected to the vessel 100 through an opening at the bottom and the middle of the vessel 100. In other words, the bottom, top or middle of the vessel 100 can all be used as connection access points. Preferably, a peristaltic pump or a stop valve is connected to the opening at the bottom of the vessel 100 to maintain the reaction liquid in the vessel 100 or discharge the liquid after the reaction is completed.

[0221] As Figure 17 shown, the device (application flow path) for quantitatively processing liquids has a vessel 100, which is used for reaction processing and / or detection and analysis and has a top opening at the top. Among them, the top opening is simultaneously connected to various basic flow paths or various combined flow paths (or their suitable combinations). Each container of various basic flow paths or various combined flow paths can be used to hold different liquids, such as distilled water, water samples to be detected, standard liquids, shielding agents, color developing agents, cleaning liquids, etc. A peristaltic pump or a stop valve is connected to the bottom of the reaction vessel 100, preferably a peristaltic pump that can be driven forward and backward (which can be used to drain liquid downward and blow air upward to stir the liquid respectively).

[0222] As Figure 18 shown, the device (application flow path) for quantitatively processing liquids has a vessel 100, which is used for reaction processing and / or detection and analysis and has a top opening at the top and a bottom opening at the bottom. Among them, the top opening and the bottom opening are simultaneously connected to various basic flow paths or various combined flow paths (or their suitable combinations). Each container of various basic flow paths or various combined flow paths can be used to hold different liquids, such as distilled water, water samples to be detected, standard liquids, shielding agents, color developing agents, cleaning liquids, etc.

[0223] As Figure 19 and Figure 20As shown, the device (application flow path) for quantitatively processing liquids has a vessel 100 for reaction processing and / or detection and analysis, with a top opening at the top and a bottom opening at the bottom. Among them, the bottom opening is simultaneously connected to various basic flow paths or various combined flow paths (or their suitable combinations). Among them, each container of various basic flow paths or various combined flow paths can be used to hold different liquids, such as distilled water, water samples to be detected, standard liquids, shielding agents, color-developing agents, cleaning solutions, etc. When the bottom opening is connected to a basic flow path or a combined flow path, not only can the container P be used to hold waste liquid, but also a cleaning solution can be held, and the cleaning solution can be introduced into the vessel 100 to facilitate the cleaning operation of the vessel 100.

[0224] As Figure 20 shown, preferably, a basic reaction flow path is formed around a reactor vessel 100. The bottoms of multiple basic reaction flow paths can be connected together to share one or several liquid discharge outlets, thereby allowing multiple reactor vessels 100 to work simultaneously, greatly improving work efficiency. As Figure 23 shown, on each connection channel between adjacent reactor vessels, at least one peristaltic pump or stop valve must be serially connected to control the on / off between the connecting pipelines.

[0225] Under the guidance of the above-mentioned connection method between the basic flow path or the combined flow path and the reactor vessel 100, many application flow path combination schemes for the device for quantitatively processing liquids can be formed.

[0226] As Figures 21 to 23 are all exemplary embodiments of connecting the basic flow path or the combined flow path scheme to the top opening of the reactor vessel 100. In this embodiment, different types of liquids (such as water samples, shielding agents, color-developing agents, etc.) can be introduced into the vessel 100 relatively independently from above, thus avoiding cross-contamination between the water samples and the reagents.

[0227] Figure 21 On the left side of the flow path, for example, a "1-K1-BC" type combined flow path is used to meter the inlet of distilled water and water samples and enter from the top of the reactor vessel 100; at the same time, on the right side, a "4-K1-B" type combined flow path is used to enter liquid from the top of the reactor vessel 100. A peristaltic pump or stop valve is connected to the bottom of the reactor vessel 100, preferably a peristaltic pump that can be driven forward and backward (which can be used for discharging liquid downward and blowing air upward to stir the liquid respectively). The advantages of this design are simple principle, concise structure, high metering accuracy, and the preparation and metering of water samples and reagents can be carried out concurrently, saving time. At the same time, the inlet of water samples and reagents does not interfere with each other and there will be no cross-contamination.

[0228] Figure 22 The flow path is on the Figure 21 basis of the flow path, and a "4-K1-BC" type combined flow path is used to replaceFigure 24 A peristaltic pump or a stop valve connected to the bottom of the middle reaction vessel 100. At the same time, two flow-through pipelines are connected at node b, which are respectively used for discharging waste liquid and metering the inflow of cleaning liquid. This design also has a liquid detector Sb connected in series on the pipeline at the bottom of the reaction vessel 100. This liquid detector, in cooperation with the peristaltic pump below, can achieve the dilution operation of the liquid.

[0229] The specific operation process is as follows: First, the water sample is introduced into the reaction vessel 100, and then the peristaltic pump Bb1 is used to drain the liquid until the last liquid just passes the liquid detector Sb. At this time, the drainage is stopped, and the peristaltic pump Bb1 or the peristaltic pump Bb2 rotates in reverse to send the intercepted fixed volume of liquid back into the reaction vessel 100. After that, the peristaltic pump Bbn starts to introduce distilled water, and the inflow volume can be determined by the liquid detector Sb in cooperation with the inflow time of the peristaltic pump Bbn. Finally, the peristaltic pump Bb1 or the peristaltic pump Bb2 rotates in reverse to blow all the diluted liquid above node b into the reaction vessel 100, completing the dilution of the original water sample. Compared with Figure 21 Figure 22 It illustrates a flow path topology structure and a dilution method for diluting a water sample based on the flow path construction idea of the present application.

[0230] Figure 23 On the left side of the flow path, a basic flow path of "1A - basic type" is used to meter the inflow of the water sample, which enters from the top of the reaction vessel 100. At the same time, on the right side, two basic flow paths of "4 - basic type" are used to introduce liquid from the top of the reaction vessel 100. The bottom of the reaction vessel 100 is connected with a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven forward and backward (which can be respectively used for draining liquid downward and blowing air upward to stir the liquid). Compared with Figure 21 the flow path, the advantage of this design is the complete separation of the two reagents on the right side, eliminating any possibility of cross - contamination.

[0231] As Figures 24 to 27 shown, they are all ways of connecting the basic flow path or the combined flow path scheme to the bottom opening of the reaction vessel 100. In this embodiment, different types of liquids (such as water samples, shielding agents, color - developing agents, etc.) can be relatively independently introduced into the vessel 100 from the bottom, and the waste liquid can be received and cleaning can be carried out. The beneficial effects of this design are as follows: Devices with the same functions such as peristaltic pumps, stop valves, and liquid detectors on different combined branches can be combined and used. For example, the pumps for draining liquid or blowing air, the distilled water pumps for cleaning, and the liquid detectors for detecting liquid, etc. In this way, the flow path can be simplified and the cost can be saved; in addition, the method of discharging and receiving liquid from the bottom of the reaction vessel 100 is also very beneficial to the cleaning of each pipeline, with high cleaning efficiency, saving cleaning water, and reducing the number of air inlets and discharge ports.

[0232] As Figure 24 shown in the flow path, it is to Figure 22The "4-K1-BC" type combined flow path with liquid inlet on the left side of the top of the flow path reaction vessel 100 and the "4-K1-B" type combined flow path with liquid inlet on the right side are moved to the bottom of the reaction vessel 100 for liquid inlet.

[0233] Figure 25 It shows a flow path that can realize the liquid inlet function more simply without reducing the number of water samples and reagents. The flow path is a "4-K1-BC type" combined flow path connected under the reaction vessel, wherein point b to point a is a common first branch, used as the output port for water samples or reagents; the branch of the series peristaltic pump Bd connected to point d is a common second branch, used to drain liquid or pump air into the main flow path, and push the measured liquid into the reaction vessel 100. The multiple branches where the peristaltic pumps Bc, Brn, Br1, and Bb are located are flow pipes. The different metering principles and liquid inlet processes of this combined flow path are Figure 4 The basic flow path and Figures 15A to 15D This has been explained in the introduction of the BC type combined flow path.

[0234] In all application flow paths of this application, the constant volume of liquid during liquid inlet can be achieved by controlling the speed and time of each liquid inlet peristaltic pump, or by controlling the positioning of the liquid segment head at a certain position near the liquid detector S ( Figure 25 ), for example in Figure 25 、 Figure 26 In the example, the liquid detector S between node a and node b can be used to accurately determine the volume of the liquid, or to provide an early warning to determine whether the liquid has passed through this point when the instrument is running.

[0235] exist Figure 26 In order to complete the liquid metering and volume determination more accurately, the series peristaltic pump Bf connected to point f can also be used to empty the liquid from point f to point a and above into the waste liquid barrel through the waste liquid branch. At this time, the right end position of the precise liquid volume determination is located by the position of the physical node f. Figure 26 This connection structure is shown.

[0236] In order to more flexibly utilize the physical space volume between the nodes on the main branch to perform constant volume operation on the liquid to be intercepted, the designer can add some branches connecting air or liquid on the main branch to intercept the volume of different micro-liquid amounts with high precision. Figure 27 An example is shown in which the designer adds a new branch for connecting air or for flushing water discharge at point e between the reagent branch and the distilled water branch to minimize cross contamination between reagents and water samples (standard solution and distilled water).

[0237] In order to completely avoid cross contamination between reagents and water samples (standard solution and distilled water), water samples and reagents can be added simultaneously. Figure 28An example is shown where the outlets of all reagents are moved to the top liquid inlet of the reaction vessel 100.

[0238] Next, we take Figure 27 as an example to illustrate the basic principles and processes of such flow path metering, liquid inlet, stirring, liquid discharge, and dilution. It should be noted that Figures 25 to 28 the corresponding principles and processes of other flow paths in

[0239] Figure 27 are similar, so the working processes of similar application flow paths will not be elaborated further.

[0240] When the peristaltic pump Bg or Be or Bf rotates counterclockwise, air can be blown into the reaction vessel 100 to stir the liquid. The above three pumps can also be used as the liquid discharge outlets.

[0241] Figure 27 The flow path realizes the dilution operation of the liquid in the reaction vessel 100 as follows: First, start the peristaltic pump Bg or Be to discharge liquid. Before the water tail passes point f, the above peristaltic pump stops. Then, rotate the peristaltic pump Bf clockwise to drain the excess liquid to be diluted outside point f. Then, rotate the peristaltic pump Bg or Be counterclockwise again to send the intercepted liquid into the reaction vessel 100. Finally, adopt the aforementioned metering liquid inlet mode to inlet distilled water into the reaction vessel 100 in the micro-liquid volume or large volume liquid inlet mode, and mix evenly after blowing air and stirring.

[0242] In Figures 22 to 28In the combined flow path at the bottom or top of the middle reaction vessel 100, at least one peristaltic pump communicates with the atmosphere. Preferably, the peristaltic pump communicating with the atmosphere is the farthest from the vessel 100 on the common thin tube. Therefore, this peristaltic pump can accurately feed all reagent containers or reagent vessels on the common thin tube into the reaction vessel 100.

[0243] Preferably, as Figures 22 to 28 shown, a liquid detector S is provided at a position where the common thin tube is adjacent to the bottom opening. Thus, it is possible to intercept a liquid with a determined volume between each bifurcation point and this liquid detector S, so as to obtain a liquid sample with a more accurately intercepted volume. The position of this liquid detector can be at any position between the intersection point b and the bottom a of the reaction vessel 100. The advantages of the liquid detector S can be referred to the detailed description above.

[0244] In addition, in all application flow paths, the arrangement order of each container P relative to the vessel 100 can be selectively designed according to the working procedure. For example, since it is necessary to push various reaction liquids by air, the peristaltic pump directly communicating with the atmosphere needs to be the farthest from the vessel 100 compared with the peristaltic pumps in series in the pipeline of other containers.

[0245] From the above description, it is obvious that in Figures 25 to 28 the shown implementation scheme, the combination of the basic flow path has achieved a high degree of dynamic integration. As Figure 26 shown, the reaction flow path further includes a waste liquid container Pf. This waste liquid container is a container communicating with the atmosphere and has a waste liquid pipeline extending out of the waste liquid container Pf from the inside of the waste liquid container Pf. A peristaltic pump Bf is serially arranged in this waste liquid pipeline. Preferably, the peristaltic pump in this waste liquid pipeline communicates with a part between the point b and the bottom opening a (at the Figure 26 bifurcation point f), and at this time, the liquid detector (S) is located near the intersection point f. As Figure 26 shown, the leftmost peristaltic pump directly communicates with the atmosphere, so as to introduce air into the common thin tube. At the same time, the waste liquid container Pf and its peristaltic pump Bf are dedicated to receiving waste liquid, thus avoiding mutual interference when introducing air; moreover, since the waste liquid container Pf is relatively close to the vessel 100, it can achieve on-site drainage, improve efficiency, and also avoid pollution of the waste liquid. The characteristics of the waste liquid container Pf can also be applied to other suitable application flow paths.

[0246] In Figure 27In the shown embodiments, an air / rinsing water discharge port container is further added to perform a dilution function. In the flow path of the present application, the method for realizing the dilution function is flexible. In addition to the aforementioned dilution scheme, different operations can also be used to achieve the dilution function. Specifically, for the liquid to be diluted in the vessel 100, first, with other peristaltic pumps stationary, the peristaltic pump of the air / rinsing water discharge port container is rotated to suck the liquid to be diluted into the air / rinsing water discharge port container. At this time, the liquid to be diluted fills between the air / rinsing water discharge port and the bottom opening a. Then, other peristaltic pumps are closed and only the peristaltic pump of the waste liquid container is rotated, so that the liquid to be diluted between the intersection point f and the bottom opening a is discharged into the waste liquid. At this time, the liquid to be diluted fills between the air / rinsing water discharge port and f. Then, other peristaltic pumps are closed and only the leftmost peristaltic pump is operated to push the liquid to be diluted between the intersection point e and f into the vessel 100 by using air. Then, distilled water is sucked into the vessel 100, thus realizing the dilution process of the liquid to be diluted.

[0247] Figure 29 Shows that on the basis of Figures 26 to 28 a "4-K2-BC type" combined flow path is adopted to replace the original liquid inlet branch roads for the water sample, standard solution, and distilled water. Since the first branch road from c1-Kc is shared, the liquid inlet volumes of the water sample, standard solution, and distilled water are the same, and it is not easy to cause cross-contamination with the reagent. If a larger volume of liquid needs to be metered, the conduit c1-Kc for volume determination can be replaced with a branch road with a thick tube connected in series in the middle, where the thick tube must open upward and the outlet is higher than the bifurcation point c1 to ensure that the liquid does not flow away from the outlet of the thick tube.

[0248] Figure 30 is to move Figure 29 the combined flow path for the water sample, standard solution, and distilled water inlet of

[0249] Figure 31 to the end of the main line flow path (the far left relative to the reaction vessel 100). Such a structure can directly use the Kc port as the air port and the discharge port for discharging rinsing water. At the same time, placing the water sample, standard solution, and distilled water at the far left is beneficial to protecting the above three liquids from contaminating the reagents or reaction solutions on the right. This kind of position adjustment of the similar basic flow path or combined flow path on the main line flow path can have various forms, not limited to the specific form shown in the figure, and these deformations are all within the scope of the present application. Figure 32 and Figure 29 respectively move Figure 30 the "4-K2-BC type" combined flow path of the main stream branch road of

[0250] Figures 25 to 32The application flow path is characterized by combining and sharing the first branches 11 and / or the second branches 12 that cooperate with each liquid inlet and outlet port, minimizing the devices (peristaltic pumps, stop valves, or liquid detectors) used in the application flow path, thereby simplifying the flow path and reducing costs.

[0251] In Figures 25 to 32 the application flow path, since the constant-volume branch pipes are shared, all reagents can only be volumetrically fixed in the common constant-volume branch pipes in sequence and then sent into the reaction vessel 100. To accelerate the metering and liquid inlet speed, the present application also proposes several application flow paths with concurrent metering that can achieve rapid analysis.

[0252] Figure 33 is based on Figure 29 and replaces the flow paths of reagent 1 to reagent n with "4-basic type" flow paths (N such reagent liquid inlet flow paths form a "4-K2-BC" combined flow path). The greatest advantage of this type of flow path is that it can achieve concurrent metering and volume fixing of the water sample and each reagent, and then rapidly feed the liquid in sequence according to the process requirements. Similarly, it can also clean each branch simultaneously, thus greatly saving the full-cycle detection time of the instrument.

[0253] It should be noted that the outlet of the first branch 11 of the "4-basic type" flow path of each reagent still returns to the reagent bottle container P. The advantage of this is that the reagent pumped out by the peristaltic pump returns to the reagent bottle, which not only saves reagents but also eliminates the influence of the bubbles that may originally exist in the thin tube. By increasing the rotation time of the peristaltic pump, the stability and high precision of the entire liquid inlet system are ensured. This structural feature and its beneficial effects are applicable to all flow paths submitted in the present application.

[0254] Figure 34 shows another practical application flow path. In it, the water sample, standard solution, and distilled water are volumetrically fixed in parallel on their respective first branches through the "4-basic type" flow path, and then connected to a higher-level "4-basic type" flow path and finally connected to the bottom of the reaction vessel 100. Each reagent is connected to the top opening of the reaction vessel 100 in the same way. The advantage of this flow path is that each liquid is metered and fed independently, with a fast speed. Especially during dilution, since the distilled water for dilution is already prepared, the dilution speed of this flow path will be very fast. To further reduce the devices, the peristaltic pumps at the "air / rinsing water discharge ports" of the upper and lower main flow branches of this application flow path can be omitted, and the air or rinsing water is directly discharged from ports such as Kb / Kc / Kd.

[0255] Figure 35 shows an application flow path that uses a stop valve group (F3, F4,..., Fn within the dashed box) and a peristaltic pump Bc2 to functionally replace Figure 33Multiple branch branches connecting to the lower end of point C1 of the connection peristaltic pump. The stop valve group can also be replaced by an N-to-1 multi-channel switching valve.

[0256] Figure 36 shows a multi-detection index extended application flow path based on Figure 33 In this flow path, reagents for 4 different detection indexes (COD, ammonia nitrogen, total phosphorus, total nitrogen) are respectively connected to the main flow path below the reaction vessel from different nodes h, g, t, r. The reaction vessel 100 is shared by the four indexes. The water sample, standard solution, and distilled water inlet channels are connected to the main flow path below the reaction vessel from point C. The drainage and pumping of air are driven by the peristaltic pump Bf and the peristaltic pump Bq, and are also shared. This application flow path can easily expand and implement the function of sequentially detecting 4 indexes at different times at a low cost by only adding a few peristaltic pumps and their control devices.

[0257] Figure 37 The flow path of Figure 36 independently separates the distilled water branch in the flow path in the structure of the "4-basic type" flow path. During the dilution operation, it can be used to complete the metering and constant volume of the distilled water for the dilution solution in advance, and the preparation time for the stock solution during the dilution operation can be reduced.

[0258] Figure 38 and Figure 39 is another practical type of application flow path. In Figure 38 , the main body connected to the bottom of the reaction vessel is a "5-K2-P type" (it can also be a "6-K2-P type") combined flow path. The "5-basic type" flow paths (it can also be "6-basic type" flow paths) are connected to the intersection points b, c, d, e, r, rn. There is an "air / rinsing water / waste liquid drain port" on the left and right sides of the flow path to achieve the functions of rapid liquid inlet and outlet and dilution. It should be noted that the peristaltic pump B at the bottom of the reaction vessel 100 can also be located on the pipeline connected to the top.

[0259] Figure 39 applies the Figure 37 combined idea, and replaces all the "4-basic type" flow paths and "4-K2-C" type combined flow paths in Figure 37 with "5-basic type" (it can also be "6-basic type") flow paths and "5-K2-P type" (it can also be "6-K2-P type") combined flow paths respectively.

[0260] In order to achieve the purpose of measuring more indexes (requiring more reagents) or implementing more functions with as few devices as possible. For example, in the analyzers for total phosphorus and total nitrogen, one reagent is the same, and customers hope to have an instrument with a two-in-one function that can measure total phosphorus and total nitrogen at the same time. Figures 40 to 42 Then several flow paths to solve the above problems are provided.

[0261] Figure 40 Based on Figure 36 , a reactor vessel is added in parallel beside the original reactor vessel 100 through the intersection point c. A stop valve Fc / Fw is connected in series to the bottom pipelines of the above two reactor vessels respectively. By controlling the opening and closing of the stop valves Fc and Fw, the respective indicator reagents connected to the lower part of the main flow path can be controlled to enter the two different reactor vessels, so as to realize the simultaneous detection of two indicators.

[0262] Figure 41 Based on Figure 39 , a reactor vessel is added in parallel beside the original reactor vessel 100 through the intersection point c. A peristaltic pump Bc / Bw is connected in series to the bottom pipelines of the above two reactor vessels respectively. By controlling the rotation and stop of the peristaltic pumps Bc / Bw, the respective indicator reagents connected to the lower part of the main flow path can be controlled to enter the two different reactor vessels, so as to realize the simultaneous detection of two indicators. The above peristaltic pumps can also be connected in series to the top sealed pipelines of the reactor vessels.

[0263] Figure 42 Shows a practical application flow path based on the H-type combined flow path. This flow path can use a small number of peristaltic pumps, stop valves, liquid detectors and 2 reactor vessels to realize the simultaneous inspection of two indicators of total phosphorus and total nitrogen. Moreover, one reagent port and the water sample, standard solution and distilled water ports used for the two indicators can also be shared.

[0264] Taking the measurement of water samples as an example, the specific liquid inlet and drainage processes are as follows: Before operation, all stop valves and peristaltic pumps on the branches are in the closed or stationary state. First, the stop valve Fe is opened, and the peristaltic pump Be1 rotates counterclockwise, and the water sample enters the thin tube at the e-Ke end and overflows and is fixed in volume; then the peristaltic pump Be1 is closed, and the peristaltic pump Bk rotates counterclockwise, and the water sample is pumped from the thin tube in the e-Ke section into the left reactor vessel, and then in the same way, the water sample is sent into the right reactor vessel. Then, in the same or similar way, various reagents are fixed in volume in the thin tube r-Kr1 or the thin tube rn-Krn in turn, and are pumped into the left and right different reactor vessels to start the reaction detection; after the detection is completed, rotating Bx, Bf, Bk, B1 clockwise (usually the flow rates of Bx and Bf are greater than those of Bk and B1) can drain the liquid.

[0265] Such as Figures 21 to 42 Are respectively schematic diagrams of the reaction flow paths of the preferred embodiments of the present application, and their working processes can be selected and applied in combination with the basic flow path and the combined flow path schemes. As shown in the accompanying drawings of the specification, the arrows in the figures can be used for corresponding explanations and can also be used to represent the replacement of adjacent figures. The zigzag line can represent a pipeline with a longer length. In addition, some ports can be refluxed to the container P to save liquid during overflow, and at the same time, pollution of the external environment can be avoided.

[0266] In addition, it should be explained that when describing the working processes of the above basic flow paths, combined flow paths, and application flow paths, the liquid inlet processes and liquid discharge processes of various basic flow paths are described in detail, and the liquid inlet processes and liquid discharge processes of some embodiments of various combined flow paths and application flow paths are described in detail by way of examples. However, it can be understood by those skilled in the art that based on the liquid inlet and liquid discharge processes of the basic flow paths, in the combined flow paths, application flow paths, and their various deformation combination embodiments, all possible embodiments in which the liquid inlet and liquid discharge methods of various basic flow paths are carried out synchronously and / or sequentially are within the scope of this application, and are not limited to the embodiments clearly disclosed in this application and its accompanying drawings.

[0267] For the sake of brevity, in this application, each combined flow path and application flow path and their liquid inlet and liquid discharge processes are not described in detail, but are described by way of examples. Therefore, for those skilled in the art, based on the content already disclosed in this application, the technical content of other combined flow paths and application flow paths that have not been described in detail can be learned. Therefore, the technical content of these combined flow paths and application flow paths is also regarded as being fully disclosed in this application.

[0268] In addition, in order to fully display the structure and operating principle of the technical solution, in this application, it is mainly described according to a three-layer architecture of basic flow paths, combined flow paths, and application flow paths. Each solution in each layer architecture has its own characteristics in actual industrial applications. Therefore, the applicant designs a patent layout for each technical solution at each level disclosed in this application, and gradually submits subsequent applications according to this patent layout to fully protect the innovative achievements of this application.

[0269] The preferred embodiments of this application have been described in detail above with reference to the accompanying drawings. However, this application is not limited to the specific details in the above embodiments. Within the scope of the technical concept of this application, various simple modifications can be made to the technical solution of this application, and these simple modifications all belong to the protection scope of this application (for example Figure 43 the flow paths shown). In addition, it should be noted that in the above specific embodiments, the various specific technical features described can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, this application does not separately explain various possible combination methods. In addition, any combination can be made between various different embodiments of this application, as long as it does not violate the idea of this application, it should also be regarded as the content disclosed in this application.

Claims

1. A device for quantitatively processing a liquid, characterized in that, The device includes: a container (P) for containing the liquid to be extracted, the container (P) being a container communicating with the atmosphere, and the flow-through pipeline (10) extending outward from inside the container (P); and a capillary tube, which includes: a flow-through pipeline (10) extending outward from inside the container (P) to a bifurcation point (a); a first branch (11) communicating with the flow-through pipeline (10) and extending from the bifurcation point (a) to a first port (K1); and a second branch (12) communicating with the flow-through pipeline (10) and extending from the bifurcation point (a) to a second port (K2); wherein, a peristaltic pump (B1) is serially arranged in the first branch (11), and a stop valve (F2) or another peristaltic pump (B2) is serially arranged in the second branch (12), wherein, in a state where the second branch (12) is blocked, the peristaltic pump (B1) arranged in the first branch (11) is driven to suck the liquid in the container (P) and make the liquid reach the first port (K1), then the peristaltic pump (B1) remains stationary but the stop valve (F2) of the second branch (12) is opened or the other peristaltic pump (B2) in the second branch (12) is driven to make the liquid between the bifurcation point (a) and the container (P) flow back to the container (P) under the action of gravity, and then the peristaltic pump (B1) is driven, the stop valve (F2) of the second branch (12) is opened or the other peristaltic pump (B2) in the second branch (12) is driven, so as to intercept a liquid with a predetermined volume between the bifurcation point (a) and the first port (K1); wherein, the aperture of the capillary tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.5 mm to 2 mm.

2. The device according to claim 1, characterized in that, The first branch (11) is a pipeline extending obliquely from the bifurcation point (a) to the first port (K1), preferably extending obliquely upward or obliquely downward.

3. The device according to claim 1 or 2, characterized in that a liquid detector (S) is arranged at a position adjacent to the first port (K1) of the first branch (11), and the liquid with a predetermined volume between the bifurcation point (a) and the first port (K1) is the liquid between the bifurcation point (a) and this liquid detector (S).

4. The device according to claim 3, characterized in that the liquid between the bifurcation point (a) and the liquid detector (S) is the liquid from the bifurcation point (a) to a predetermined offset point based on the liquid detector (S).

5. A method for quantitatively processing a liquid, characterized in that, This method quantitatively processes liquid based on the device according to any one of claims 1-4, and this method includes: in a state where the second branch (12) is blocked, the peristaltic pump (B1) arranged in the first branch (11) is driven to suck the liquid in the container (P) and make the liquid reach the first port (K1); The peristaltic pump (B1) remains stationary, but the shut-off valve (F2) of the second branch (12) is opened or driven by the other peristaltic pump (B2) in the second branch (12), so that the liquid between the bifurcation point (a) and the container (P) flows back to the container (P) under the action of gravity; and The peristaltic pump (B1) is driven, the shut-off valve (F2) of the second branch (12) is opened or the other peristaltic pump (B2) in the second branch (12) is driven, so as to be able to intercept a liquid of a predetermined volume between the bifurcation point (a) and the first port (K1).

Images