Magnesium alloy composite material and preparation method and application thereof

Abstract

The invention discloses a magnesium alloy composite material and a preparation method and application thereof, and belongs to the technical field of magnesium alloy materials. The magnesium alloy composite material comprises a polymer and a magnesium alloy material, and the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 50%. The composite material can be obtained by blending a polymer and a magnesium alloy material. The magnesium alloy composite material can be used for preparing devices or medicines for treating eye diseases, and is particularly used for preparing glaucoma drainage implantation instruments. Before magnesium alloy is degraded, the glaucoma drainage implantation instrument containing the magnesium alloy composite material is small in flow capacity, and low intraocular pressure can be prevented; after the magnesium alloy is degraded, a porous structure can be formed, so that the flow capacity of the drainage implantation instrument is increased, a normal drainage effect is achieved, and in addition, the magnesium alloy can also play a role in slowly releasing magnesium ions.

Description

Technical Field

[0001] The present invention relates to the technical field of magnesium alloy materials, and in particular, to a magnesium alloy composite material, a preparation method thereof, and an application thereof. Background Art

[0002] Glaucoma and cataract are common clinical ophthalmic diseases that can cause vision loss or even blindness in patients. Glaucoma drainage tubes are a promising treatment method for glaucoma and can be more minimally invasive than traditional trabeculectomy. However, current glaucoma drainage tubes are prone to causing low intraocular pressure.

[0003] In view of this, the present invention is specifically proposed. Summary of the Invention

[0004] The purpose of the present invention is to provide a magnesium alloy composite material, a preparation method thereof, and an application thereof to solve or improve the above technical problems.

[0005] This application can be implemented as follows:

[0006] In a first aspect, this application provides a magnesium alloy composite material, which includes a polymer and a magnesium alloy material, and the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 50%.

[0007] In an optional embodiment, the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 30%.

[0008] In an optional embodiment, the magnesium alloy material is uniformly distributed in the polymer.

[0009] In an optional embodiment, the polymer includes at least one of polyisobutylene, poly(styrene-b-isobutylene-b-styrene) triblock copolymer, polyurethane, polytetrafluoroethylene, acrylate, and silica gel.

[0010] In an optional embodiment, the polymer includes at least one of polyurethane, acrylate, and poly(styrene-b-isobutylene-b-styrene) triblock copolymer.

[0011] In an optional embodiment, the average particle size of the magnesium alloy material does not exceed 1 mm.

[0012] In an optional embodiment, the average particle size of the magnesium alloy material is 10 nm to 1 mm.

[0013] In a second aspect, this application provides a preparation method of a magnesium alloy composite material according to any one of the foregoing embodiments, including the following steps: blending the polymer and the magnesium alloy material.

[0014] In an alternative embodiment, the blending temperature is 100°C to 300°C, and the blending time is 5 minutes to 120 minutes.

[0015] In a third aspect, the present application provides an application of a magnesium alloy composite material according to any one of the foregoing embodiments in the preparation of devices or drugs for treating eye diseases.

[0016] In a fourth aspect, the present application provides a glaucoma drainage implant device, the preparation raw materials of which include the magnesium alloy composite material according to any one of the foregoing embodiments.

[0017] The beneficial effects of the present application include:

[0018] The present application can prepare a magnesium alloy composite material in which magnesium alloy materials are effectively distributed in a polymer in a simple manner. The magnesium alloy composite material can be used to prepare devices or drugs for treating eye diseases, especially for preparing glaucoma drainage implant devices. Before the magnesium alloy in the glaucoma drainage implant device containing the above magnesium alloy composite material degrades, the flow capacity of the drainage implant device is small, which can prevent low intraocular pressure; after the magnesium alloy degrades, a porous structure can be formed, making the flow capacity of the drainage implant device larger, achieving a normal drainage effect. In addition, it can also play a role in slowly releasing magnesium ions. Description of the Drawings

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for use in the embodiments. It should be understood that the following drawings only show some embodiments of the present invention, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, other related drawings can also be obtained based on these drawings without creative efforts.

[0020] Figure 1 Micrograph of the magnesium alloy composite material prepared in Example 1;

[0021] Figure 2 XRD pattern of the magnesium alloy composite material prepared in Example 1;

[0022] Figure 3 Micrograph of the magnesium alloy composite material prepared in Example 1 after magnesium degradation;

[0023] Figure 4 Micrograph of the drainage tube prepared from the magnesium alloy composite material provided in Example 1 before degradation;

[0024] Figure 5 Micrograph of the drainage tube prepared from the magnesium alloy composite material provided in Example 1 after degradation;

[0025] Figures 6 to 19They are respectively the physical pictures of the magnesium alloy composites prepared in Examples 1 to 10 and Comparative Examples 1, 3 to 5. Detailed implementation manners

[0026] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. For those not specified in the embodiments, they are carried out according to conventional conditions or the conditions recommended by the manufacturer. For the reagents or instruments whose manufacturers are not specified, they are all conventional products that can be obtained through commercial purchase.

[0027] The magnesium alloy composite material provided in the present application, its preparation method, and application will be specifically described below.

[0028] The present application provides a magnesium alloy composite material, which includes a polymer and a magnesium alloy material, and the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 50%.

[0029] It should be noted that multiple eye regions of the human body (such as vitreous body and aqueous humor) contain magnesium, and magnesium can play a role in maintaining the function and structural integrity of eye tissues, and is also crucial in maintaining retinal function. By compounding the magnesium alloy with the polymer to prepare a composite material, the present application can be used to improve ophthalmic diseases.

[0030] In the above magnesium alloy composite material, the magnesium alloy material is distributed in the polymer. In some preferred implementation manners, the magnesium alloy material is uniformly distributed in the polymer.

[0031] As a reference, the mass percentage of the magnesium alloy material in the magnesium alloy composite material can be 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10%, or 5%, etc., or other amounts not exceeding 50%.

[0032] In some relatively typical implementation manners, the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 30%.

[0033] If the mass percentage of the magnesium alloy material in the magnesium alloy composite material exceeds 50%, it will result in too little polymer, making it difficult to form a sufficient polymer network for the magnesium alloy material to be embedded in, and ultimately difficult to form a complete composite material, which is likely to become debris.

[0034] In the present application, the polymer may include, by way of example but not limitation, at least one of polyisobutylene, poly(styrene-b-isobutylene-b-styrene) triblock copolymer (SIBS), polyurethane, acrylate, and silica gel. In some more typical embodiments, the polymer includes at least one of polyurethane, acrylate, and poly(styrene-b-isobutylene-b-styrene) triblock copolymer. Among them, acrylate may include, by way of example but not limitation, substances such as polymethyl methacrylate, etc.

[0035] The average particle size of the magnesium alloy material used in the present application does not exceed 1 mm. In some more typical embodiments, the average particle size of the magnesium alloy material is 10 nm to 1 mm, such as 10 nm, 50 nm, 100 nm, 200 nm, 500 nm, 800 nm, or 1000 nm, etc., and can also be any other value within the range of 10 nm - 1 mm. In some specific embodiments, the average particle size of the magnesium alloy material is 20 μm or 50 μm.

[0036] If the average particle size of the magnesium alloy material is too large, on the one hand, it is difficult to embed it into the polymer, and on the other hand, the degradation effect is poor, which is not conducive to the formation of Mg 2+ Enter the eye.

[0037] For reference, the magnesium alloy material used in the present application can be pure magnesium particles or other alloy materials containing magnesium.

[0038] Correspondingly, the present application also provides a preparation method of the above magnesium alloy composite material, including the following steps: blending the polymer and the magnesium alloy material.

[0039] In some embodiments, the blending can be carried out in common polymer blending equipment, and in other embodiments, the blending can also be carried out in a screw extruder.

[0040] For reference, the blending temperature can be 100°C to 300°C, such as 100°C, 150°C, 200°C, 250°C, or 300°C, etc., and can also be any other value within the range of 100°C to 300°C.

[0041] If the blending temperature is lower than 100°C, the polymer is difficult to soften, resulting in difficulty in embedding the magnesium alloy material into the polymer, or the magnesium alloy material and the polymer will be unevenly mixed; if the blending temperature is higher than 300°C, it is easy to cause the polymer to degrade or age, and it is difficult to obtain a magnesium alloy composite material with qualified quality.

[0042] The blending time can be 5 min to 120 min, such as 5 min, 10 min, 20 min, 50 min, 80 min, 100 min, or 120 min, etc., and can also be any other value within the range of 5 min to 120 min.

[0043] Similarly, if the blending time is shorter than 5 min, it is difficult for the polymer to soften, resulting in difficulty in embedding the magnesium alloy material into the polymer, or uneven mixing of the magnesium alloy material and the polymer; if the blending time is longer than 120 min, it is easy to cause polymer degradation or aging, and it is difficult to obtain a magnesium alloy composite material with qualified quality.

[0044] In addition, the present application also provides an application of the above magnesium alloy composite material in the preparation of devices or drugs for treating eye diseases.

[0045] Correspondingly, the present application also provides a glaucoma drainage implant device, the preparation raw materials of which include the above magnesium alloy composite material.

[0046] Exemplarily, the glaucoma drainage implant device can be a glaucoma drainage tube or an intraocular lens, etc. Among them, the form of the glaucoma drainage tube can include a single-chamber tube, a double-chamber tube, and a multi-chamber tube. The number of cavities in the "multi-chamber tube" > 2.

[0047] Before the degradation of the magnesium alloy, the flow capacity of the glaucoma drainage tube containing the above magnesium alloy composite material is small, which can prevent low intraocular pressure; after the degradation of the magnesium alloy, the composite material can form a porous structure, increasing the flow capacity of the drainage tube and achieving a normal drainage effect. In addition, it can also play a role in slowly releasing magnesium ions, enabling the effective absorption of magnesium ions.

[0048] The features and properties of the present invention will be further described in detail below in conjunction with embodiments.

[0049] Example 1

[0050] This example provides a magnesium alloy composite material, and its preparation includes: blending a poly(styrene-b-isobutylene-b-styrene) triblock copolymer (SIBS) and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 90:10. The blending temperature is 150 °C, and the blending time is 10 min.

[0051] Example 2

[0052] This example provides a magnesium alloy composite material, and its preparation includes: blending a poly(styrene-b-isobutylene-b-styrene) triblock copolymer and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 90:10. The blending temperature is 100 °C, and the blending time is 30 min.

[0053] Example 3

[0054] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a poly(styrene-b-isobutylene-b-styrene) triblock copolymer and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 90:10. The blending temperature is 200 °C, and the blending time is 5 min.

[0055] Example 4

[0056] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polyurethane and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 95:5. The blending temperature is 180 °C, and the blending time is 30 min.

[0057] Example 5

[0058] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polyurethane and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 95:5. The blending temperature is 200 °C, and the blending time is 10 min.

[0059] Example 6

[0060] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polyurethane and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 95:5. The blending temperature is 250 °C, and the blending time is 5 min.

[0061] Example 7

[0062] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polymethyl methacrylate and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 95:5. The blending temperature is 180 °C, and the blending time is 20 min.

[0063] Example 8

[0064] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polymethyl methacrylate and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 90:10. The blending temperature is 180 °C, and the blending time is 25 min.

[0065] Example 9

[0066] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending a polymethyl methacrylate and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 80:20. The blending temperature is 180 °C, and the blending time is 30 min.

[0067] Example 10

[0068] This embodiment provides a magnesium alloy composite material, and its preparation includes: blending polymethyl methacrylate and pure magnesium particles with an average particle size of 100 μm in a blender at a mass ratio of 70:30. The blending temperature is 180 °C and the blending time is 30 min.

[0069] Comparative Example 1

[0070] The difference between this comparative example and Example 1 is that: the mass ratio of poly(styrene-b-isobutylene-b-styrene) triblock copolymer (SIBS) to pure magnesium particles with an average particle size of 100 μm is 40:60.

[0071] The remaining conditions remain unchanged.

[0072] Comparative Example 2

[0073] The difference between this comparative example and Example 1 is that: the average particle size of the magnesium alloy material is 1.5 mm.

[0074] The remaining conditions remain unchanged.

[0075] Comparative Example 3

[0076] The difference between this comparative example and Example 1 is that: the blending temperature is 80 °C.

[0077] The remaining conditions remain unchanged. Comparative Example 4

[0078] The difference between this comparative example and Example 1 is that: the blending temperature is 320 °C.

[0079] The remaining conditions remain unchanged. Comparative Example 5

[0080] The difference between this comparative example and Example 1 is that: the blending time is 2 min.

[0081] The remaining conditions remain unchanged. Comparative Example 6

[0082] The difference between this comparative example and Example 1 is that: the blending time is 140 min.

[0083] The remaining conditions remain unchanged.

[0084] Test Example 1

[0085] ① Taking Example 1 as an example, the prepared magnesium alloy composite material was observed under a microscope, and the results are as Figure 1 shown.

[0086] From Figure 1 it can be seen that: in the magnesium alloy composite material prepared in this embodiment, the magnesium particles are evenly distributed in the poly(styrene-b-isobutylene-b-styrene) triblock copolymer.

[0087] ②. Taking Example 1 as an example, the prepared magnesium alloy composite material was subjected to XRD analysis, and the results are as Figure 2 shown.

[0088] It can be seen from Figure 2 that: in the magnesium alloy composite material prepared in this example, the characteristic peaks of both poly(styrene-b-isobutylene-b-styrene) triblock copolymer (SIBS) and Mg are superimposed.

[0089] ③. Taking Example 1 as an example, the prepared magnesium alloy composite material was degraded with PBS buffer solution, and the degraded material was observed under a microscope. The results are as Figure 3 shown.

[0090] It can be seen from Figure 3 that: after the magnesium in the magnesium alloy composite material is degraded, a porous structure is formed in the magnesium alloy composite material.

[0091] ④. The magnesium alloy composite material prepared in Example 1 was made into a drainage tube, and the micrograph of the obtained drainage tube is as Figure 4 shown. It can be seen from Figure 4 that magnesium particles are evenly mixed in the tube wall.

[0092] Furthermore, the above drainage tube was degraded, and the micrograph of the degraded drainage tube is as Figure 5 shown. It can be seen from Figure 5 that after the drainage tube is degraded, a through-channel is formed in its tube wall.

[0093] ⑤. The physical diagrams of the magnesium alloy composite materials prepared in Examples 1 to 10 and Comparative Examples 1, 3 to 5 are as Figures 6 to 19 shown.

[0094] It can be seen from Figures 6 to 15 that better magnesium alloy composite materials can be prepared in Examples 1 to 10. It can be seen from Figure 16 that: in Comparative Example 1, due to the too high proportion of pure magnesium particles, the internal bonding ability of the magnesium alloy composite material is poor, and delamination and splitting have occurred. It can be seen from Figure 17 that: in Comparative Example 3, the plasticization is insufficient and the material components are not evenly mixed. It can be seen from Figure 18 that: in Comparative Example 4, the blending temperature is too high, and the material is oxidized and turns yellowish-black. It can be seen from Figure 19 that: in Comparative Example 5, the blending time is insufficient and the material is not evenly mixed.

[0095] In addition, in Comparative Example 2, the average particle size of the magnesium alloy material is too large, and the thickness of the prepared glaucoma drainage implant device is too thick to be applied to intraocular drainage. The blending time of Comparative Example 6 is too long, which increases energy consumption, and the material system has aged and oxidized.

[0096] In summary, the present application can prepare a magnesium alloy composite material with effectively distributed magnesium alloy material in the polymer in a simple manner. This magnesium alloy composite material can be used to prepare medical devices or drugs for treating eye diseases, especially for preparing glaucoma drainage implant devices (such as drainage tubes, etc.). Before the degradation of the magnesium alloy in the glaucoma drainage tube containing the above magnesium alloy composite material, the flow capacity of the drainage tube is small, which can prevent low intraocular pressure; after the degradation of the magnesium alloy, a porous structure can be formed, making the flow capacity of the drainage tube larger and achieving a normal drainage effect. In addition, it can also play a role in slowly releasing magnesium ions.

[0097] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A magnesium alloy composite material, characterized in that, The magnesium alloy composite material comprises a polymer and a magnesium alloy material, and the mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 50%.

2. The magnesium alloy composite material according to claim 1, characterized in that, The mass percentage of the magnesium alloy material in the magnesium alloy composite material does not exceed 30%.

3. The magnesium alloy composite material according to claim 1, wherein The magnesium alloy material is uniformly distributed in the polymer.

4. The magnesium alloy composite material according to any one of claims 1 to 3, characterized in that The polymer comprises at least one of polyisobutylene, poly(styrene-b-isobutylene-b-styrene) triblock copolymer, polyurethane, polytetrafluoroethylene, acrylate, and silica gel.

5. The magnesium alloy composite material according to claim 4, wherein, The polymer comprises at least one of polyurethane, acrylate, and poly(styrene-b-isobutylene-b-styrene) triblock copolymer.

6. The magnesium alloy composite material according to any one of claims 1 to 3, characterized in that, The average particle size of the magnesium alloy material does not exceed 1 mm; Preferably, the average particle size of the magnesium alloy material is 10 nm to 1 mm.

7. A method for preparing a magnesium alloy composite material according to any one of claims 1 to 6, characterized in that, It includes the following steps: blending the polymer and the magnesium alloy material.

8. The preparation method according to claim 7, wherein, The blending temperature is 100 °C to 300 °C, and the blending time is 5 min to 120 min.

9. Use of a magnesium alloy composite material according to any one of claims 1 to 6 in the preparation of a device or a drug for treating eye diseases.

10. A glaucoma drainage implant device, characterized in that, The raw materials for preparing the glaucoma drainage implant device include the magnesium alloy composite material according to any one of claims 1 to 6.

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