Traditional Chinese medicine composition for treating hepatic fibrosis and method for preparing external-application detoxifying chemical fiber paste by using traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine composition for treating hepatic fibrosis and a method for preparing external-application detoxification chemical fiber paste by using the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating hepatic fibrosis is prepared from angelica sinensis, radix paeoniae alba, herba lycopi, cowherb seeds, rheum officinale, sedum sarmentosum, astragalus membranaceus and liquorice, and the angelica sinensis and the radix paeoniae alba are used for nourishing blood and liver, soothing the liver and promoting the circulation of qi and serve as monarch drugs; the cowherb seed and the herba lycopi are used for promoting qi, activating blood and inducing diuresis and are used as minister Rheum officinale and sedum sarmentosum are used for clearing away heat and toxic materials; the radix astragali and the liquorice are used for tonifying qi and deficiency and harmonizing the medicines to serve as guides. The detoxification chemical fiber paste prepared from the traditional Chinese medicine composition has the characteristics of simplicity in use, reliable curative effect, no obvious toxic or side effect and the like, can be independently used, and also can be used as a matched medicine for oral administration treatment, so that the curative effect is further improved; the invention provides a novel medicine and a novel treatment method for treating chronic liver diseases and hepatic fibrosis caused by various reasons (viruses, ethanol, high fat diet, autoimmunity, schistosome, medicines or toxins and the like).

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine formulas, and in particular to a traditional Chinese medicine composition for treating liver fibrosis and a method for preparing an external application detoxification and fiber-forming cream using the composition. Background Art

[0002] Liver fibrosis refers to the excessive proliferation and abnormal deposition of collagen in the liver's extracellular matrix (ECM), which leads to the massive proliferation of fibrous connective tissue and pathological changes in liver structure or function. Liver damage can be caused by various etiologies, such as ethanol, viruses, toxins, drugs, or cholestasis. Excessive accumulation of ECM in the liver alters liver structure, leading to fibrosis. If the fibrosis process cannot be effectively controlled, it can eventually lead to cirrhosis and even liver cancer, posing a significant threat to patients. Furthermore, the high cost of treatment places a heavy burden on patients' families and society. Therefore, delaying, curbing, and even reversing the process of fibrosis is crucial for the prevention and treatment of cirrhosis and liver cancer.

[0003] The pathological process of liver fibrosis primarily involves the release of growth factors such as tumor necrosis factor-α, transforming growth factor-β1, platelet-derived growth factor, insulin-like growth factor I, and vascular endothelial growth factor by damaged hepatocytes, hepatic macrophages (i.e., Kupffer cells), sinusoidal endothelial cells, and platelets, which promote the activation of hepatic stellate cells. Activated hepatic stellate cells then transform into myofibroblast-like cells. Activated hepatic stellate cells and myofibroblast-like cells, in turn, continuously stimulate their own secretion of transforming growth factor-β1, further activating hepatic stellate cells. Studies have also shown that microRNAs, long noncoding RNAs, and exosomes are involved in the activation of hepatic stellate cells. Hepatic stellate cells are activated through these paracrine and autocrine pathways, continuously proliferating and clustering at sites of liver injury. They secrete large amounts of extracellular matrix components and proinflammatory cytokines, resulting in increased extracellular matrix deposition and decreased degradation, increased expression of α-smooth muscle activator protein, and excessive proliferation of fibrous connective tissue. In addition, transforming growth factor β1 can also activate the gene transcription of the extracellular matrix and increase its expression, inhibit the expression of matrix metalloproteinases and increase the expression of tissue metalloproteinase inhibitors to reduce the decomposition of extracellular matrix components, thereby causing excessive production of extracellular matrix with collagen as the main component, and ultimately causing the occurrence and development of liver fibrosis.

[0004] Hepatic stellate cells play a leading role in the development of liver fibrosis. Signaling pathways associated with hepatic stellate cell activation and their upstream and downstream molecules are highly promising targets for blocking hepatic stellate cell activation and reversing liver fibrosis. The development and reversal of liver fibrosis is a complex process involving multiple cells and cytokines. Profibrotic cytokines include tumor necrosis factor-α, transforming growth factor-β1, platelet-derived growth factor, interleukin-1, interleukin-8, interleukin-6, and leptin; while antifibrotic cytokines include inhibitors of matrix metalloproteinases, hepatocyte growth factor, interleukin-4, and interleukin-10. These factors, through various signal transduction pathways, mediate the activation and apoptosis of hepatic stellate cells, regulate extracellular matrix levels, and ultimately control the progression of liver fibrosis. Therefore, whether to effectively inhibit the activation and proliferation of hepatic stellate cells or promote their production of reduced extracellular matrix components and increase their degradation is crucial for reversing liver fibrosis. Therefore, the development process of liver fibrosis is complex, and various cytokines and cellular pathways "communicate" and influence each other, forming a complex network of interactions.

[0005] As can be seen from the above, the current research on the pathogenesis of liver fibrosis has made great progress. Although there is a lot of research and development work on anti-liver fibrosis drugs, most of them are in preclinical research, and their main treatment symptoms are not liver fibrosis. There are almost no clinically specific therapeutic drugs for liver fibrosis. Western medicine currently treats liver fibrosis mainly by eliminating the cause, protecting liver tissue, inhibiting activated hepatic stellate cells, and increasing extracellular matrix degradation. There are no drugs to reverse liver fibrosis, and the clinical efficacy is unsatisfactory. Traditional Chinese medicine treatment effectively makes up for this shortcoming. Traditional Chinese medicine treatment of liver fibrosis has been widely accepted in China, and its efficacy has been confirmed.

[0006] The term "liver fibrosis" does not exist in ancient Chinese medical texts. Liver fibrosis falls under the traditional medical categories of "accumulation," "lumps," "liver obstruction," "piss syndrome," "bloating," "flank pain," and "jaundice." While physicians hold varying opinions, most now believe that the name of liver fibrosis closely resembles "accumulation." Key clinical symptoms include fatigue, flank pain, flank masses, and jaundice, and the condition may be absent. Regarding this disease, the Su Wen states, "Where evil gathers, the Qi must be weak." Zhang's Yi Tong, in line with the Su Wen, states, "Accumulation is caused by insufficient righteous Qi, which then allows evil Qi to take hold." When the body lacks righteous Qi, external pathogens can easily invade the weakened body, leaving the body unable to resist the evil, leading to a host of diseases. Therefore, deficiency of righteous Qi is crucial to the development of liver fibrosis. The Golden Chamber states the symptoms of accumulation: "Accumulation is a disease of the internal organs and is permanent; accumulation is a disease of the internal organs and occurs at specific times." The Prescriptions for Emergencies states that accumulation is caused by exposure to cold pathogens, leading to blood stagnation and accumulation. "Accumulation begins when cold strikes, and accumulation occurs when the cold stops." Zhang Jingyue believed that accumulation is caused by spleen and stomach deficiency. A weak spleen and stomach leads to insufficient production of qi and blood. Exposure to pathogens in any of the four seasons can cause accumulation. "Weak spleen and stomach, qi and blood deficiency, and seasonal exposure can all lead to accumulation." Modern physician Chen Guozhong believes that liver fibrosis is a dysfunction of the liver's drainage function, which directly affects the rise and fall of qi, the circulation of qi and blood, the transportation and transformation of food and water by the spleen and stomach, and the metabolism of fluids. Disharmony between the liver-wood and spleen-earth organs causes fluid to stagnate and form phlegm, leading to qi and blood stagnation in the liver. The combination of phlegm and blood stasis is the key to its formation, with the liver and spleen being the primary sites of disease. Chen Guoliang believes that liver fibrosis is a progressive disease process, initially caused by damp-heat pathogenic toxins. Over time, these pathogenic factors invade the interior, leading to qi stagnation, spleen dysfunction, poor blood circulation, and stasis. This dynamic process progresses from excess to deficiency, from the exterior to the interior, and from qi to blood. Deficiency of vital energy and blood stasis are key to the development of liver fibrosis, with deficiency of the underlying body and excess of the superficial. Qi stagnation, damp-heat, toxic pathogens, and blood stasis are superficial excess, while deficiency of qi, blood, liver, spleen, and kidney is the underlying deficiency. Ma Jizheng et al. discussed the etiology and pathogenesis of liver fibrosis from five perspectives: blood stasis, vital energy deficiency, turbid phlegm, toxic pathogens, and collateral disorders. They concluded that liver fibrosis is often caused by a deficiency of vital energy. Multiple pathogenic factors, including qi, blood, dampness, heat, stasis, and toxic substances, invade the body, resulting in blood vessel obstruction, qi stagnation, and blood stasis. The disease is localized in the liver and spleen, and all five internal organs are implicated. The basic pathogenesis is summarized as deficiency of vital energy, with the prevalence of pathogenic pathogens, prolonged invasion of toxic pathogens, and the invasion of collaterals, which damages the liver collaterals and leads to qi stagnation and blood stasis.

[0007] Other researchers have aligned the Western medical mechanisms of liver fibrosis with TCM pathogenesis theory to guide syndrome differentiation and treatment. The pathogenesis of liver fibrosis is summarized as "deficiency leading to accumulation." "Deficiency" primarily manifests in spleen qi deficiency, liver qi deficiency, and liver and kidney yin essence deficiency, manifesting as damage to the hepatic sinusoidal wall and a decrease in the number and function of hepatic parenchymal cells. "Accumulation" primarily manifests in heat, dampness, toxicity, and blood stasis blocking the collaterals, manifesting as pathological changes such as excessive deposition of extracellular matrix in the liver and capillarization of the hepatic sinusoids. Modern TCM experimental studies of liver fibrosis adhere to TCM theory, applying TCM etiologies to generate corresponding TCM syndromes. This creates a combined disease-syndrome animal model of liver fibrosis that exhibits both Western medical and TCM syndromes. This allows for the exploration of the evolution of liver fibrosis and the screening of effective TCM treatments. This fully embodies the unique characteristics of TCM and provides a theoretical basis for the treatment of liver fibrosis with TCM. In the 1990s, Chinese scholars proposed through laboratory research and clinical trials that the synthesis and decomposition of fibrous connective tissue in the liver are in a dynamic equilibrium process under normal circumstances. When the two contradictory opposing sides lose balance, liver fibrosis and cirrhosis will occur. Traditional Chinese medicine is one of the effective means to reverse liver fibrosis.

[0008] Among the many treatment methods in Traditional Chinese Medicine (TCM), herbal patch therapy, with its unique meridian conduction and therapeutic effects, is a major hallmark of TCM. It can achieve the goal of external treatment for internal illnesses while avoiding the potential liver and stomach damage associated with internal medications. Furthermore, it offers therapeutic benefits unattainable with internal treatments. According to the principles of meridian theory, meridians are crucial components of the human body, connecting the interior and exterior, the upper and lower parts, and the internal and external organs. Applying herbal patches to acupoints allows the absorption of the drug through the acupoints, allowing the drug's physical and chemical stimulation to directly affect the multi-layered and multifunctional meridian system. This interaction stimulates and synergizes the effects, resulting in a synergistic effect, thus achieving the goal of external treatment for internal illnesses. Modern medical research has also confirmed the unique sensitivity of meridian acupoints to the physical and chemical stimulation of drugs, their amplification, overall regulation, and drug storage. This is a key mechanism in TCM's approach to external treatment for internal illnesses. Summary of the Invention

[0009] The technical problem to be solved by the present invention is to address the deficiencies of the above-mentioned prior art and provide a traditional Chinese medicine composition for treating liver fibrosis and a method for preparing a detoxification and fibrosis-removing paste for external application. Angelica sinensis and white peony root nourish blood and soften the liver, soothe the liver and promote qi circulation, and are the main ingredients; Vaccaria segetalis and Zedoariae rhizome promote qi circulation, activate blood circulation and promote diuresis, and are the ministers; Rhubarb and Herba Coptidis clear away heat and detoxify, and are the adjuvants; Astragalus and Licorice root invigorate qi, replenish deficiency and harmonize the other medicines, and are the envoys. The detoxification and fibrosis-removing paste has the characteristics of being simple to use, having a reliable efficacy and having no obvious toxic and side effects. It can be used alone or as a combination medicine for internal treatment, which further improves the efficacy. It provides a new medicine and treatment method for the treatment of chronic liver disease and liver fibrosis.

[0010] A traditional Chinese medicine composition for treating liver fibrosis is composed of the following raw materials in parts by weight: 6-30 parts of angelica sinensis, 6-30 parts of white peony root, 9-30 parts of zedoaria officinalis, 6-30 parts of fenugreek, 1-15 parts of rhubarb, 10-30 parts of creeping vine, 9-30 parts of astragalus and 3-15 parts of liquorice.

[0011] 2. The traditional Chinese medicine composition for treating liver fibrosis according to claim 1 is characterized in that it is composed of the following raw materials in parts by weight: 9 parts of angelica sinensis, 15 parts of white peony root, 15 parts of zedoaria officinalis, 10 parts of vaccaria segetalis, 3 parts of rhubarb, 15 parts of creeping vine, 15 parts of astragalus and 5 parts of licorice.

[0012] The present invention also provides a method for preparing an external detoxification and fibrosis-removing ointment using the above-mentioned traditional Chinese medicine composition for treating liver fibrosis, comprising the following steps: Step 1: Mix angelica, white peony root, zedoaria, vaccaria, rhubarb, scutellaria baicalensis, astragalus and licorice, grind into powder, sieve and set aside; Step 2: Mix warm boiled water and honey to obtain a mixed solution, add the sieved powder in S1 to the mixed solution, prepare it into a paste, and evenly spread it on the external application fixing patch to obtain an external application detoxification and chemical fiber paste.

[0013] According to the method for preparing an external detoxification and fibrosis ointment for the Chinese medicinal composition for treating liver fibrosis provided by the present invention, the particle size of the powder after sieving in step 1 is ≤120 μm.

[0014] According to the method for preparing an external detoxification and fibrosis ointment for the Chinese medicinal composition for treating liver fibrosis provided by the present invention, the volume ratio of warm boiled water and honey in step 2 is 1:3, and the volume mass ratio of the mixed solution and powder is 4:1.

[0015] According to the method for preparing an external application detoxification and fibrosis-removing ointment for the Chinese medicinal composition for treating liver fibrosis provided by the present invention, the thickness of the external application detoxification and fibrosis-removing ointment in step 2 is 0.3 to 0.5 cm.

[0016] According to the traditional Chinese medicine composition for treating liver fibrosis provided by the present invention, the liver fibrosis is caused by viruses, ethanol, high-fat diet, autoimmunity, schistosomiasis, drugs or toxins.

[0017] In the prescription, angelica and white peony root are used to nourish blood and soften the liver, soothe the liver and promote qi circulation, which are the main ingredients; the liver is responsible for regulating qi, water and blood throughout the body, with fenugreek and zelantoide as the ministers to promote qi, activate blood circulation and promote diuresis; rhubarb and creeping vine are used to clear away heat and detoxify, which are the auxiliary ingredients, and creeping vine is also a proven medicine for treating liver disease; in order to prevent the strong elimination of evil from damaging the body, astragalus and licorice are added to replenish qi, nourish deficiency and harmonize the various medicines.

[0018] Compared with the prior art, the present invention has the following advantages: The traditional Chinese medicine composition for treating liver fibrosis of the present invention is composed of angelica, white peony root, zedoaria, fenugreek, rhubarb, scutellaria baicalensis, astragalus and licorice. Angelica and white peony root nourish blood and soften liver, soothe liver and promote qi circulation, and are the main ingredients; fenugreek and zedoaria promote qi, activate blood circulation and promote diuresis, and are the minister ingredients; rhubarb and scutellaria baicalensis clear away heat and detoxify, and are the adjuvant ingredients; astragalus and licorice invigorate qi, replenish deficiency and harmonize all the medicines, and are the guiding ingredients.

[0019] The detoxification and fibrosis-reducing paste prepared from the traditional Chinese medicine composition has the characteristics of simple use, reliable efficacy, and no obvious toxic side effects. It can not only be used alone, but also be used as a combined medicine for oral treatment to further improve the efficacy. It provides a new medicine and treatment method for the treatment of chronic liver disease and liver fibrosis caused by viruses, ethanol, high-fat diet, autoimmunity, schistosomiasis, drugs or toxins.

[0020] The present invention will be further described in detail below with reference to the embodiments. DETAILED DESCRIPTION

[0021] Example 1

[0022] This embodiment provides a traditional Chinese medicine composition for treating liver fibrosis, which is composed of the following raw materials in parts by weight: 9 parts of angelica sinensis, 15 parts of white peony root, 15 parts of zedoaria officinalis, 10 parts of fenugreek, 3 parts of rhubarb, 15 parts of creeping vine, 15 parts of astragalus and 5 parts of liquorice.

[0023] This embodiment also provides a method for preparing an external detoxification and fibrosis-removing ointment using the above-mentioned traditional Chinese medicine composition for treating liver fibrosis, comprising the following steps: Step 1: Mix angelica, white peony root, zedoaria, vaccaria, rhubarb, scutellaria baicalensis, astragalus and licorice, grind into powder, and pass through a 120-mesh sieve for later use; Step 2: Mix warm boiled water and honey in a volume ratio of 1:3 to obtain a mixed solution, add the sifted powder in S1 to the mixed solution in a volume mass ratio of 4:1, and prepare it into a paste. The paste should be fixed in shape and the drug should not overflow. Evenly spread it on the external application fixing patch of the plaster. The size of the external application fixing patch is 10×15 cm. The external application detoxification and chemical fiber paste is obtained, and the thickness of the plaster is 0.3 to 0.5 cm.

[0024] Before applying the detoxification and chemical fiber paste prepared in this example, the patient is instructed to empty his bowels and bladder, lie flat on his back, expose the ribs or liver area, and select acupoints such as Zhangmen, Qimen, Burong, and Chengman.

[0025] Apply the plaster to the above-mentioned acupuncture points and fix it with adhesive tape. If the patient needs to get up and walk, use a multi-head strap to fix it. Apply once a day, 1 patch (60g) each time, for 6 to 8 hours, and use it continuously for 1 month.

[0026] The nature of liver fibrosis is deficiency of the root and excess of the superficial symptoms, with pathogenic factors prevalent and the body weak. Treatment should focus on eliminating pathogenic factors while not forgetting to replenish the deficiency. Among them, the "evil factors" are qi stagnation, blood stasis, and internal accumulation of dampness and heat.

[0027] The treatment strategy is guided by the principle that "the liver stores blood and regulates qi". In the prescription, angelica and white peony root are used to nourish blood and soften the liver, regulate liver qi and regulate qi, and are the main ingredients. The liver governs the regulation of qi, water, and blood throughout the body, with Vaccaria segetalis and Ze Lan acting as assistants to regulate qi, blood, and diuresis. Rhubarb and Herba Lycopodii are used as adjuvants to clear away heat and detoxify. Herba Lycopodii is also a proven medicine for treating liver diseases. In order to prevent the strong elimination of evil from damaging the body, astragalus and licorice are added to replenish qi, nourish deficiency and harmonize the other medicines.

[0028] If the applied area shows signs of allergy such as redness, itching, or blisters, stop using the product.

[0029] Detoxification and Fiber Removal Paste has the characteristics of simple use, reliable efficacy, and no obvious toxic side effects. It can not only be used alone, but also as a combination of oral treatment to further improve the efficacy, providing a new drug and treatment method for the treatment of chronic liver disease and liver fibrosis.

[0030] Example 2 This embodiment provides an external detoxification and fibrosis-removing paste for treating liver fibrosis, which is composed of the following raw materials in parts by weight: 6 parts of angelica sinensis, 6 parts of white peony root, 9 parts of zedoaria officinalis, 6 parts of fenugreek, 1 part of rhubarb, 10 parts of creeping vine, 9 parts of astragalus and 3 parts of licorice.

[0031] This embodiment also provides a method for preparing the above-mentioned external detoxification and chemical fiber paste for treating liver fibrosis, comprising the following steps: Step 1: Mix angelica, white peony root, zedoaria, vaccaria, rhubarb, scutellaria baicalensis, astragalus and licorice, grind into powder, and pass through a 120-mesh sieve for later use; Step 2: Mix warm boiled water and honey in a volume ratio of 1:3 to obtain a mixed solution, add the sifted powder in S1 to the mixed solution in a volume mass ratio of 4:1, and prepare it into a paste. The paste should be fixed in shape and the drug should not overflow. Evenly spread it on the external application fixing patch of the plaster. The size of the external application fixing patch is 10×15 cm. The external application detoxification and chemical fiber paste is obtained, and the thickness of the plaster is 0.3 to 0.5 cm.

[0032] Example 3 This embodiment provides an external detoxification and fiber-forming paste for treating liver fibrosis, which is composed of the following raw materials in parts by weight: 30 parts of angelica sinensis, 30 parts of white peony root, 30 parts of zedoaria officinalis, 30 parts of fenugreek, 15 parts of rhubarb, 30 parts of creeping vine, 30 parts of astragalus and 15 parts of licorice.

[0033] This embodiment also provides a method for preparing the above-mentioned external detoxification and chemical fiber paste for treating liver fibrosis, comprising the following steps: Step 1: Mix angelica, white peony root, zedoaria, vaccaria, rhubarb, scutellaria baicalensis, astragalus and licorice, grind into powder, and pass through a 120-mesh sieve for later use; Step 2: Mix warm boiled water and honey in a volume ratio of 1:3 to obtain a mixed solution, add the sifted powder in S1 to the mixed solution in a volume mass ratio of 4:1, and prepare it into a paste. The paste should be fixed in shape and the drug should not overflow. Evenly spread it on the external application fixing patch of the plaster. The size of the external application fixing patch is 10×15 cm. The external application detoxification and chemical fiber paste is obtained, and the thickness of the plaster is 0.3 to 0.5 cm.

[0034] Example 4 In this embodiment, the external application detoxification and chemical fiber cream prepared in Example 1 was selected.

[0035] The external application detoxification and fibrosis cream is suitable for patients with chronic liver disease and liver fibrosis caused by various reasons (such as viruses, ethanol, high-fat diet, autoimmunity, schistosomiasis, drugs or toxins, etc.).

[0036] The following patients are prohibited from using this product: those with severe skin diseases and skin damage; those with severe blood diseases and sensory disorders; those who are allergic to patch medications and adhesive plasters; those with decompensated cirrhosis and severe complications such as upper gastrointestinal bleeding and hepatic encephalopathy; those with severe primary diseases of other organs, such as heart failure, kidney failure, etc.; pregnant or lactating women.

[0037] This embodiment uses a plaster to apply the detoxifying and fibrous ointment to the flanks or liver area to treat chronic liver disease and liver fibrosis. The drug can be directly absorbed through the skin through osmosis and enter the local liver meridians to exert its therapeutic effect. This route of administration can quickly take effect locally and avoid drug metabolism in the liver through the gastrointestinal tract. It is convenient, safe, easily accepted by patients, and has no obvious adverse reactions. It is worthy of clinical promotion and application.

[0038] The detoxification and fibrosis cream prepared in Example 1 was used to treat 100 patients with various types of chronic liver disease and liver fibrosis (viral hepatitis, alcoholic liver disease, fatty liver, autoimmune liver disease, etc.), including 84 males and 16 females. 92 patients showed significant effects and 8 patients showed no effect. The liver fibrosis index of the patients with significant effects was effectively reduced.

[0039] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any way. Any simple modification, change and equivalent variation made to the above embodiment based on the essence of the invention technology shall still fall within the scope of protection of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for treating liver fibrosis, characterized in that: The invention is composed of the following raw materials in parts by weight: 6-30 parts of angelica sinensis, 6-30 parts of white peony root, 9-30 parts of zedoaria officinalis, 6-30 parts of fenugreek, 1-15 parts of rhubarb, 10-30 parts of creeping vine, 9-30 parts of astragalus and 3-15 parts of liquorice.

2. The Chinese medicine composition for treating liver fibrosis according to claim 1, characterized in that The invention is composed of the following raw materials in parts by weight: 9 parts of angelica sinensis, 15 parts of white peony root, 15 parts of zedoaria officinalis, 10 parts of fenugreek, 3 parts of rhubarb, 15 parts of creeping vine, 15 parts of astragalus and 5 parts of liquorice.

3. A method for preparing an external detoxification and fiber-forming cream using the Chinese medicine composition for treating liver fibrosis according to any one of claims 1 to 2, characterized in that: The following steps are involved: Step 1: Mix angelica, white peony root, zedoaria, vaccaria, rhubarb, scutellaria baicalensis, astragalus and licorice, grind into powder, sieve and set aside; Step 2: Mix warm boiled water and honey to obtain a mixed solution, add the sieved powder in S1 to the mixed solution, prepare it into a paste, and evenly spread it on the external application fixing patch to obtain an external application detoxification and chemical fiber paste.

4. A method for preparing an external detoxification and fiber-forming paste using the Chinese medicine composition for treating liver fibrosis according to claim 3, characterized in that: The particle size of the powder after sieving in step 1 is ≤120 μm.

5. A method for preparing an external detoxification and fiber-forming paste using the Chinese medicine composition for treating liver fibrosis according to claim 3, characterized in that: In step 2, the volume ratio of warm boiled water to honey is 1:3, and the volume mass ratio of the mixed solution to powder is 4:

1.

6. A method for preparing an external detoxification and fiber-forming paste using the Chinese medicinal composition for treating liver fibrosis according to claim 3, characterized in that: The thickness of the externally applied detoxification and chemical fiber cream in step 2 is 0.3 to 0.5 cm.

7. The Chinese medicine composition for treating liver fibrosis according to claim 1, characterized in that: The liver fibrosis is caused by viruses, ethanol, high-fat diet, autoimmunity, schistosomiasis, drugs or toxins.