Intelligent integrated wound treatment bandage based on multi-physiological index monitoring and electric response hydrogel

Abstract

The invention discloses an intelligent integrated wound treatment bandage based on multi-physiological index monitoring and electric response hydrogel. The intelligent integrated wound treatment bandage comprises a bandage body, a physiological index monitoring yarn, an electric activity hydrogel layer, a voltage modulation electrode and a portable control module. The bandage body is made of a breathable material with good biocompatibility, the bandage body and the physiological index monitoring yarn are integrally woven, and the wound state can be monitored in real time. The electroactive hydrogel layer is prepared into a structure similar to football alkene C60 and covers the inner side of the bandage body, medicine can be responsively released under the action of an electric field, and wound healing is promoted. The structure can ensure that wound exudate is not blocked, so that the wound exudate smoothly penetrates through the hydrogel layer to reach the physiological index monitoring yarn. The voltage modulation electrode is embedded in the bandage body, and the drug release rate is regulated and controlled by applying different voltage signals, and electrical stimulation treatment is carried out on a wound. The portable control module can receive the physiological data of the wound in real time and automatically adjust the voltage signal according to the physiological data of the wound, personalized treatment is achieved, the data can be uploaded to a smart phone or a cloud server, and remote monitoring of medical staff is facilitated.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to an intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel. Background Art

[0002] Wound healing is a complex and delicate physiological process involving multiple stages such as inflammation, proliferation and remodeling. During the wound healing process, the physiological indicators of the wound (such as temperature, pH, NH4 + , glucose, lactate, and uric acid) are crucial for assessing wound status and adjusting treatment plans in a timely manner. However, while traditional bandages provide basic protection, they lack the ability to monitor the wound's physiological environment in real time, which often leads to a delayed treatment response and affects healing efficiency.

[0003] While some smart bandage technologies have been developed to monitor certain physiological indicators of wounds, most of these products rely on external sensors, which not only complicates their use but can also affect data accuracy due to poor direct contact between the sensor and the wound. Furthermore, traditional bandages primarily rely on passive moisturizing and physical isolation to promote wound healing, offering limited functional support for accelerating inflammation, preventing infection, and promoting tissue repair.

[0004] To address these issues, the research community has recently begun exploring the design of smart bandages that integrate electronic components with bioactive materials, aiming to enable direct, real-time monitoring of wound physiological indicators and, in combination with drug delivery systems, active treatment. For example, some studies have embedded conductive polymers or nanomaterials into bandages to create smart platforms capable of monitoring bioelectrical signals. However, these platforms often overlook the intelligent release of drugs and the dynamic regulation of the wound microenvironment, and often focus on monitoring a single or limited set of physiological indicators.

[0005] This paper proposes an intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogels. This bandage incorporates an innovative stimuli-responsive electroactive hydrogel that can regulate the drug release rate in response to changes in specific wound physiological indicators, such as decreased pH or increased temperature. Furthermore, the bandage incorporates built-in voltage modulation electrodes that not only precisely control drug release from the hydrogel but also apply appropriate electrical stimulation based on wound needs to promote cell proliferation, accelerate tissue repair, and enhance antibacterial effects. Summary of the Invention

[0006] The purpose of the present invention is to provide an intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel to address the technical defects of existing wound care, such as insufficient monitoring, limited treatment effect and uncontrollable drug release.

[0007] The technical solution adopted to achieve the purpose of the present invention is:

[0008] An intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel, including a bandage body, physiological indicator monitoring yarn, an electroactive hydrogel layer, a voltage modulation electrode and a portable control module.

[0009] The bandage body is made of breathable and biocompatible materials, and 3 to 6 physiological indicator monitoring yarns are embedded inside. These yarns are evenly distributed in the wound area and can monitor key physiological indicators of the wound area in real time.

[0010] The electroactive hydrogel layer covers the inner side of the bandage body and directly contacts the wound. In the electroactive hydrogel layer, drug molecules are loaded into the hydrogel network through chemical bonds or physical encapsulation. When the voltage modulation electrode applies a specific electric field, the molecular structure of the hydrogel will respond to the action of the electric field.

[0011] The voltage modulation electrode is embedded in the bandage body and is in direct contact with the hydrogel layer. By applying different voltage signals, it can not only regulate the release rate of the drug in the hydrogel, but also perform electrical stimulation treatment on the wound area to accelerate tissue repair and blood circulation.

[0012] The portable control module, connected to the physiological indicator monitoring yarn and voltage modulation electrodes, houses a built-in microprocessor and wireless communication module. It receives and analyzes wound physiological data in real time, automatically adjusting the voltage signal based on a pre-set algorithm to dynamically adjust personalized treatment plans. Furthermore, the control module uploads data to a smartphone or cloud server via Bluetooth or Wi-Fi, enabling remote monitoring and timely adjustments to treatment plans by medical staff.

[0013] In the above technical solution, the physiological indicator monitoring yarn has extremely high sensitivity and stability, ensuring the accuracy of the monitoring data, and is woven integrally with the bandage body to ensure close contact with the wound.

[0014] In the above technical solution, the electroactive hydrogel layer is prepared into a shape similar to "football olefin C 60 The "structure" can ensure that wound exudate is not blocked, allowing it to smoothly pass through the hydrogel layer to reach the physiological indicator monitoring yarn for monitoring. Moreover, through the intelligent response mechanism, the hydrogel layer can release drugs on demand under electric field stimulation, reducing waste and improving treatment effects.

[0015] In the above technical solution, the voltage modulation electrode is made of biocompatible material, embedded in the bandage body, and the surface is specially treated to ensure that it will not cause irritation or allergies to the patient's skin during long-term use.

[0016] In the above technical solution, the portable control module is designed to be compact and lightweight, easy to wear, and has a built-in battery that supports long-term operation and can be charged via USB, making it convenient for daily use.

[0017] In the above technical solution, the edge of the bandage body is designed with an easy-to-tear seal, which makes it easy to change the bandage without disturbing the wound while keeping the wound area clean and sterile.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] 1. In the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention, the physiological indicator monitoring yarn is woven into an integrated manner with the bandage body, and the voltage modulation electrode is embedded in the bandage body, which can avoid the problem of poor contact with the wound affecting the accuracy of the data and reduce the phenomenon of component detachment. The electroactive hydrogel layer is prepared into a similar "football olefin C 60 The "structure" is covered on the inner side of the bandage body, which can ensure that the wound exudate is not blocked, allowing it to pass smoothly through the hydrogel layer to reach the physiological indicator monitoring yarn for monitoring.

[0020] 2. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention can monitor multiple physiological indicators of the wound in real time through the built-in yarn-shaped sensor, providing doctors with more comprehensive and accurate wound status data, which helps to adjust the treatment plan in time and accelerate the wound healing process.

[0021] 3. The voltage modulation electrode in the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention can not only adjust the release rate of drugs in the hydrogel by precisely controlling the voltage to achieve personalized treatment, but also directly apply weak electrical stimulation to the wound area to promote cell proliferation and angiogenesis, further accelerating wound healing.

[0022] 4. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention achieves the dual synergistic effect of drug release and electrical stimulation therapy through electric field regulation. The voltage modulation electrode can dynamically adjust the porosity and permeability of the electroactive hydrogel by applying a specific electric field to achieve on-demand drug release; the simultaneous application of a weak electric field or a specific frequency electric field can directly stimulate cell proliferation, angiogenesis and collagen synthesis in the tissues around the wound, while enhancing local blood circulation and inhibiting bacterial biofilm formation. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 Shown is a front structural schematic diagram of the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel of the present invention.

[0024] Figure 2 Shown is a schematic diagram of the internal structure of the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel of the present invention.

[0025] Figure 3 Shown is a partial schematic diagram of the monitoring yarn embedded in the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention.

[0026] Figure 4 Shown is a schematic diagram of the stimulus-responsive electroactive hydrogel of the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel of the present invention.

[0027] Figure 5 Shown is a schematic diagram of the electrical stimulation current trend of the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel of the present invention.

[0028] Figure 6 Shown is a diagram showing the working principle of the intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel of the present invention.

[0029] In the figure: 1 smart bandage body, 2 seal, 3 physiological indicator monitoring yarn, 3-1 temperature sensor, 3-2 pH sensor, 3-3 NH4 + Sensor, 3-4 glucose sensor, 3-5 lactate sensor, 3-6 uric acid sensor, 3-7 reference electrode, 3-8 counter electrode, 4 stimulus-responsive electroactive hydrogel, 5-1 voltage modulation electrode (positive electrode), 5-2 voltage modulation electrode (negative electrode), 6 portable control module. DETAILED DESCRIPTION

[0030] The present invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0031] Example 1

[0032] See also Figure 1-5 , an intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electro-responsive hydrogel, including: a bandage body 1, a physiological indicator monitoring yarn 3, a stimulus-responsive electroactive hydrogel 4, a voltage modulation electrode and a portable control module 6.

[0033] The bandage body 1 is made of antibacterial fiber with good elasticity and antibacterial properties. The physiological index monitoring yarn 3 (including reference electrodes 3-7 and counter electrodes 3-8) is woven into an integrated whole with the bandage body 1. These yarn sensors are evenly distributed inside the bandage, corresponding to the location of the wound. These yarn sensors can monitor the temperature, pH, NH4 +, glucose, lactic acid, uric acid and other physiological indicators, thereby comprehensively reflecting the physiological environment of the wound and its metabolic state.

[0034] The stimuli-responsive electroactive hydrogel 4 was prepared into a similar "football-like" 60 The "structure" is arranged on the inner surface of the bandage body 1 and is in direct contact with the wound. The hydrogel can respond to the signal of the voltage modulation electrode to achieve precise release of the drug. The hydrogel can be loaded with dual-functional anti-inflammatory and antimicrobial peptides. The combination of these two drugs can more effectively inhibit wound infection, reduce inflammatory response, and promote wound healing. In the electroactive hydrogel layer, drug molecules are loaded into the hydrogel network by chemical bonds or physical encapsulation. When the voltage modulation electrode applies a specific electric field, the molecular structure of the hydrogel will undergo responsive changes due to the action of the electric field. The specific mechanism is as follows: (1) The electroactive hydrogel is composed of charged polymer chains (such as polyelectrolytes). After the voltage is applied, the charged groups inside the hydrogel undergo directional migration driven by the electric field, causing the hydrogel network to reversibly swell or shrink. This structural change changes the porosity of the hydrogel, thereby regulating the expansion and contraction of the drug molecules. Dissipation rate. For example, a positive voltage may cause the hydrogel to shrink (pores to shrink), slowing down drug release; a negative voltage may cause it to swell (pores to expand), accelerating drug release. (2) If the drug molecules loaded in the hydrogel are themselves electrically active (such as charged anti-inflammatory peptides), the electric field can directly drive the directional movement of drug molecules through electrodialysis or electromigration. For example, positively charged drug molecules migrate toward the wound under the attraction of the negative electric field, achieving targeted release. (3) The intensity (voltage value) and frequency of the electric field can precisely regulate the rate of drug release. For example: a low-frequency pulsed electric field (such as 0.1-1Hz) can periodically open the pores of the hydrogel to achieve intermittent drug release; a constant DC electric field (such as 0.5-3V) can achieve linear release by continuously changing the permeability of the hydrogel; a high-frequency AC electric field (such as 10-100Hz) can inhibit sudden drug release and maintain a stable concentration.

[0035] The voltage-modulating electrodes are embroidered onto the center of the bandage and at the edge of the wound. The voltage-modulating electrode (negative electrode) 5-2 located at the center of the bandage contacts the hydrogel. By controlling the electrode voltage (amplitude range: 0.5V to 3V (DC) or peak-to-peak 1V to 5V (AC / Pulse), frequency range: 0.1Hz to 100Hz (low-frequency pulse) or 10Hz to 10kHz (high-frequency AC)), the release rate and amount of the drug from the hydrogel can be precisely adjusted. The electrical stimulation function (current intensity: 50μA to 200μA (promoting cell proliferation) or 100μA to 500μA (enhancing antibacterial / blood circulation)) can also be achieved, stimulating cell proliferation and differentiation around the wound and accelerating the wound healing process. For example, a microcurrent (e.g., 50-200μA) can activate fibroblasts and keratinocytes around the wound, accelerating their proliferation; an electric field of a specific frequency (e.g., 10Hz) can enhance local blood circulation and reduce the accumulation of inflammatory factors.

[0036] The portable control module 6 has an integrated sophisticated circuit system, specifically including: (1) Power management circuit: built-in rechargeable lithium polymer battery (typical capacity: 300-500mAh, voltage: 3.7V), integrated battery charging management chip (supports USB Type-C interface, input voltage: 5V±5%, charging current: 0.5-1A) and low-dropout linear regulator (LDO) / switching regulator (DC-DC), providing a stable, multi-channel output working voltage (for example: 1.8V, 3.3V, 5V) for the entire system. It has a low power consumption mode and battery power monitoring function. (2) Signal acquisition and conditioning circuit: Contains a multi-channel (corresponding to a variety of physiological indicator monitoring sensors) low-noise analog front end (AFE). AFE usually includes an instrumentation amplifier (for weak signal amplification, with adjustable gain range: 1-1000 times), an anti-aliasing filter (the cut-off frequency is set according to the sensor characteristics, typically in the range of 0.1Hz-100Hz) and a high-precision analog-to-digital converter (ADC, resolution: ≥16 bits, sampling rate: 1-100SPS programmable). This circuit is responsible for receiving physiological indicators to monitor yarn 3 (such as temperature sensor 3-1, pH sensor 3-2, NH4 +The weak electrical signals (such as voltage, current, and impedance) output by the sensor 3-3, etc. are amplified, filtered, and digitally converted. (3) Microprocessor Unit (MCU): A low-power, high-performance embedded microcontroller (such as an ARM Cortex-M series core, with a main frequency of 48-120MHz) is used, with built-in program memory (Flash) and data memory (RAM). The MCU runs the core control algorithm (such as PID control and state machine logic) and is responsible for: reading and processing the multi-channel sensor data converted by the ADC; analyzing the wound status in real time according to the preset algorithm (for example, a decision tree or machine learning model based on the wound pH value, temperature, and infection marker concentration); generating precise voltage modulation signal control instructions (including voltage amplitude, polarity, waveform - such as DC, pulse PWM, AC - and its frequency and duty cycle) and drug release control instructions based on the analysis results and the preset treatment strategy; and managing the data transmission and reception of the wireless communication module. (4) Electrode drive circuit: Receives control instructions from the MCU and generates precise and controllable voltage / current signals to be applied to the voltage modulation electrodes (5-1 positive electrode, 5-2 negative electrode). This circuit typically includes: ① A digital-to-analog converter (DAC): This converts the MCU's digital control instructions into an analog voltage reference (resolution: ≥12 bits). ② A precision voltage / current source amplifier: Based on the DAC output, it provides programmable drive capability. Key parameter ranges include: Output voltage range: -5V to +5V (or 0V to 5V, depending on the hydrogel and electrical stimulation requirements); Output current capability: Maximum ±5mA (sufficient to cover the required electrical stimulation and drug release control current); Supported waveform outputs: Constant DC, square wave pulses (PWM frequency range: 0.1Hz to 100Hz, duty cycle: 10%-90%), and sine wave / AC (AC frequency range: 1Hz to 10kHz). ③ A current monitoring and protection circuit: This circuit monitors the current flowing through the electrode and tissue in real time (typical electrical stimulation treatment current range: 50μA to 500μA), ensuring it remains within safe limits (e.g., <1mA) to prevent overcurrent damage to tissue. It also includes open / short circuit detection and protection. (5) Wireless communication module: integrated with Bluetooth low energy (BLE 5.0+, transmission distance: >10 meters) and / or Wi-Fi (such as 802.11b / g / n) chip and antenna. Responsible for transmitting the physiological data of the treated wound (such as temperature: accuracy ±0.1℃, range 32-42℃; pH: accuracy ±0.1, range 4.0-9.0; NH4 + The system uploads data such as concentration (detection limit 0.1mM), system status (battery level, operating mode, alarm information), and treatment parameter settings to a smartphone app or cloud server (upload interval can be set from 5 minutes to 60 minutes). It also receives downlink commands from the cloud or app (such as adjusting treatment parameters and starting / stopping monitoring or treatment).

[0037] Example 2

[0038] Based on Example 1, the physiological indicator monitoring yarn 3 was optimized. The yarn uses more advanced sensing materials (such as functionalized carbon nanotube yarns, conductive polymer composite nanofibers), which improves the accuracy and stability of monitoring (such as long-term drift of pH monitoring <0.05pH / day, temperature response time <1 second). In addition to using electrochemical deposition to prepare yarns, nanofiber technologies such as electrospinning can also be used to integrate sensing materials. At the same time, the types and quantities of physiological indicator monitoring yarns 3 are increased (for example, a dissolved oxygen sensor is added - measuring range: 0-100% air sat., accuracy: ±2%; a humidity sensor - measuring range: 20-100% RH, accuracy: ±3% RH), which can monitor more wound physiological indicators and provide more data support for a comprehensive assessment of the wound.

[0039] Furthermore, improvements have been made to the stimuli-responsive electroactive hydrogel, increasing the variety of drugs (such as antibiotics and growth factors) and increasing drug loading (loading rate: 5-20wt%) and release efficiency. By adjusting the hydrogel's formulation (such as monomer ratio and cross-linker concentration) and preparation process, it can respond more sensitively and linearly to signals from the voltage-modulated electrode (for example, applying 1V DC can increase the release rate of a specific drug by 2-5 times), achieving timed and quantitative drug release.

[0040] Example 3

[0041] Based on Example 1, the voltage modulation electrode is personalized. According to the size, location and type of the wound (such as chronic ulcer, burn, surgical incision), the shape and size of the electrode can be adjusted (electrode effective area: 0.1cm 2 Up to 2cm 2 ) and position (electrode spacing: 0.5cm to 3cm) to meet the needs of different wounds. For example, for larger wounds (>5cm 2 ), the number or area of electrodes can be increased to expand the stimulation range; for deeper wounds (>0.5cm), the electrodes can be placed closer to the bottom of the wound to increase the penetration depth of the electric field and the therapeutic effect (current density range in tissue: 100μA / cm 2 Up to 500μA / cm 2 ).

[0042] At the same time, the software algorithm inside the portable control module 6 has been upgraded, adding more complex intelligent algorithms (such as adaptive fuzzy PID control based on real-time sensor data, simple machine learning prediction model) and adaptive control functions. The control module can automatically and dynamically adjust the drug release rate (basic release rate: 0.1-5μg / cm2 / h, can reach 1-50μg / cm under stimulation response 2 / h) and electrical stimulation parameters (voltage, current, frequency, and duty cycle are automatically optimized within the specified range) to achieve highly personalized treatment plans. In addition, the control module also has voice prompts and remote control functions, which can remind patients to change bandages or adjust treatment plans in a timely manner. Medical staff can also remotely control the bandage's operation (such as setting / modifying parameter thresholds and triggering emergency drug release) via smartphones or cloud servers.

[0043] Example 4

[0044] Based on Examples 1-3, see Figure 6 The working process of an intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electroresponsive hydrogel includes:

[0045] Step 1: Wrap the smart bandage around the wound and adjust the bandage seal to suit the size and location of the wound. Ensure that the physiological indicator monitoring yarn 3 is in full contact with the wound to accurately monitor the wound status.

[0046] Step 2: Power the portable control module 6 with a battery, start the portable control module 6, and control the physiological indicator monitoring yarn 3 through the integrated microprocessor module to start working. The physiological indicator monitoring yarn 3 begins to monitor various physiological indicators of the wound in real time and transmits the data to the portable control module 6.

[0047] Step 3: The MCU inside the portable control module 6 analyzes and processes the received data. According to the actual situation of the wound (such as pH < 6.0 (strong acidic infection environment) or temperature > 38.5 ° C (local inflammation and fever)) and the preset algorithm, it automatically generates and outputs a control signal to the electrode drive circuit to accurately adjust the drug release parameters of the stimulus-responsive electroactive hydrogel 4 (such as applying -1.5V DC for 10 minutes to quickly release antimicrobial peptides) and the electrical stimulation parameters of the voltage-modulated electrode (such as applying 100μA, 20Hz square wave pulses to promote angiogenesis). For example, when the wound shows signs of infection (such as NH4 + When the concentration is >1.0 mM), the drug release amount and rate can be increased; when the wound heals slowly (such as low glucose, hypoxia), the electrical stimulation parameters can be adjusted to enhance the stimulation intensity (such as increasing the current to 150 μA) or change the frequency (such as switching to 50 Hz AC to inhibit biofilm).

[0048] Step 4: The portable control module 6 uploads the wound monitoring data and treatment results to the smartphone and cloud server via the wireless communication module. Medical staff can check the wound condition in real time and adjust the treatment plan as needed.

[0049] Step 5: During the wound healing process, the patient can regularly change the bandage or perform necessary cleaning and care. The portable control module 6 can record the wound healing process and treatment effect to provide a reference for subsequent treatment.

[0050] For ease of explanation, spatial relative terms such as "upper", "lower", "left", and "right" are used in the embodiments to illustrate the relationship between one element or feature shown in the figures and another element or feature. It should be understood that, in addition to the orientation shown in the figures, spatial terms are intended to include different orientations of the device in use or operation. For example, if the device in the figure is inverted, the element described as being "under" other elements or features will be positioned "above" other elements or features. Therefore, the exemplary term "under" can include both upper and lower orientations. The device can be positioned in other ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used here can be interpreted accordingly.

[0051] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel, characterized in that: It includes a bandage body, physiological indicator monitoring yarn, an electroactive hydrogel layer, a voltage modulation electrode and a portable control module. The bandage body is made of breathable and biocompatible materials, and is embedded with 3 to 6 physiological indicator monitoring yarns. These yarns are evenly distributed in the wound area and can monitor key physiological indicators of the wound area in real time. The electroactive hydrogel layer covers the inner side of the bandage body and directly contacts the wound. In the electroactive hydrogel layer, drug molecules are loaded into the hydrogel network through chemical bonds or physical embedding. When a specific electric field is applied by the voltage modulation electrode, the molecular structure of the hydrogel undergoes responsive changes due to the action of the electric field. The voltage modulation electrode is embedded in the bandage body and is in direct contact with the hydrogel layer. By applying different voltage signals, it can not only regulate the release rate of the drug in the hydrogel, but also perform electrical stimulation treatment on the wound area, accelerating tissue repair and blood circulation. The portable control module is connected to the physiological indicator monitoring yarn and voltage modulation electrode, and has a built-in microprocessor and wireless communication module. It can receive and analyze wound physiological data in real time, automatically adjust the voltage signal according to a preset algorithm, and realize dynamic adjustment of personalized treatment plans. At the same time, the control module can upload data to a smartphone or cloud server via Bluetooth or Wi-Fi, making it convenient for medical staff to remotely monitor and timely adjust treatment plans.

2. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel according to claim 1 is characterized in that: The physiological indicator monitoring yarn has extremely high sensitivity and stability, ensuring the accuracy of the monitoring data, and is woven integrally with the bandage body to ensure close contact with the wound.

3. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel according to claim 1, characterized in that: The electroactive hydrogel layer was prepared into a similar "footballene C 60 The "structure" can ensure that wound exudate is not blocked, allowing it to smoothly pass through the hydrogel layer to reach the physiological indicator monitoring yarn for monitoring. Moreover, through the intelligent response mechanism, the hydrogel layer can release drugs on demand under electric field stimulation, reducing waste and improving treatment effects.

4. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel according to claim 1, characterized in that: The voltage modulation electrode is made of biocompatible material, embedded in the bandage body, and its surface is specially treated to ensure that it will not cause irritation or allergies to the patient's skin during long-term use.

5. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel according to claim 1, characterized in that: The portable control module is compact and lightweight, easy to wear, and has a built-in battery that supports long-term operation and can be charged via USB, making it convenient for daily use.

6. The intelligent integrated wound treatment bandage based on multi-physiological indicator monitoring and electrical response hydrogel according to claim 1, characterized in that: The bandage body is designed with an easy-tear seal on the edge, allowing for easy bandage changes without disturbing the wound while keeping the wound area clean and sterile.

Images