Device and method for quantifying a liquid

Abstract

The invention relates to the field of liquid treatment, and discloses a liquid quantitative treatment scheme which comprises a container used for containing liquid to be extracted or discharged; and a slim tube, the slim tube comprising: a through-flow line extending outwardly from the inside of the container to a bifurcation point; the first branch is communicated with the through-flow pipeline and extends to a first port from the bifurcation point; the second branch is communicated with the through-flow pipeline and extends to a second port from the bifurcation point; wherein a peristaltic pump is arranged in at least one of the through-flow pipeline, the first branch and the second branch in a series connection mode, and a stop valve or another peristaltic pump is arranged in at least the other of the through-flow pipeline, the first branch and the second branch in a series connection mode. And a predetermined volume of liquid between the bifurcation point and the first port or the second port can be intercepted.

Description

[0001] This application is a divisional application of the Chinese patent application with application number 2021100876082, application date January 22, 2021, and name “Device for quantitative processing of liquid”. Technical Field

[0002] The present application relates to the field of liquid processing, analysis or detection, and in particular, to a device for quantitatively processing liquid. Background Art

[0003] Currently, many technical fields involve the processing and / or analysis of liquids. For example, in the medical field, the food field, laboratory analysis, agriculture, forestry, animal husbandry, and fishery, the analysis of samples requires quantitative processing of the sample to be tested and the reagents. For another example, in the field of environmental protection, water quality testing requires intercepting a small quantitative sample and performing testing and analysis on the small sample. Among them, the accuracy of the intercepted amount of the liquid to be tested has a vital direct impact on the test results. If the sample cannot be accurately intercepted or the sampling volume of the liquid cannot be known, it will lead to large errors in the test results.

[0004] Traditionally, although many analytical instruments or liquid handling devices are capable of accurately injecting liquids in a smaller volume range (such as 0.05 ml to 2 ml), the objects to be tested are usually relatively clear and clean liquids that have undergone pre-treatment such as flocculation, sedimentation, and filtration under laboratory conditions. In addition, the costs of liquid pre-treatment equipment and labor are usually high.

[0005] This traditional solution is difficult to meet the actual working conditions of the current industry, because it is difficult to ensure the cleanliness of the liquid to be tested under certain actual working conditions. On the other hand, once the liquid to be tested is pretreated, the clean liquid will obviously be different from the actual liquid at the first site (such as COD, total phosphorus, total nitrogen, etc. in water quality testing), which is likely to affect the accuracy of the measurement, and even the suspended matter or impurities in the liquid may clog the pretreatment pipeline. For another example, for online monitoring in harsh working conditions, such as electroplating processing liquids, wet smelting mineral solutions, environmental protection sewage wastewater and other online detection fields, traditional technical solutions cannot achieve accurate quantitative detection of harsh liquids to be tested under such working conditions. In particular, there is a lack of a trace (such as 0.05-2 ml) liquid quantification technology that can be easy to maintain or even maintenance-free at a relatively low cost and for a relatively long time.

[0006] In addition, a typical quantitative metering flow path currently widely used in the field of analytical instruments and liquid processing is the "sequential injection" liquid inlet metering technology. This flow path technology has good stability, but in the past decade, with the emergence of a series of demanding new requirements for instruments and equipment such as low cost, high precision, taking into account both micro-inlet volume (such as 0.05-2 ml) and regular inlet volume (such as 2-10 ml) and rapid measurement and detection, several inherent defects of the traditional sequential injection liquid inlet metering technology have become increasingly apparent: for example, first, due to the need to apply multi-channel switching valves (or valve groups) and liquid inlet metering and detection devices, the cost of flow path devices in such traditional devices is relatively high; secondly, in the flow path scheme of such traditional devices, the liquid inlet and discharge need to be carried out sequentially in a transfer manner, so the operation steps are relatively It is complicated and takes a long time, which leads to relatively low overall work efficiency; thirdly, a more serious defect is that if the detection process requires continuous feeding of water samples and several different reagents under certain working conditions, the flow path in the traditional solution can only measure these water samples and reagents in sequence, and sometimes the pipeline needs to be fully cleaned when the next reagent is fed in, which causes the overall analysis process of the instrument to take too long, seriously affecting work efficiency; finally, in the flow path of the traditional device, the transfer pipeline has a long stroke, which can easily cause liquid to stick to the wall or remain inside the catheter and device, resulting in low measurement accuracy when performing micro-liquid processing.

[0007] In view of this, how to overcome at least some of the above-mentioned technical defects in traditional solutions, at least to a certain extent, has become a technical problem that needs to be urgently solved in this field. Summary of the Invention

[0008] The present application provides a novel solution for quantitatively processing liquids. To achieve the above-mentioned purpose, the present application provides a device for quantitatively processing liquids, the device comprising: a container for containing liquid to be extracted; and a capillary tube, the capillary tube comprising: a flow line extending outward from the interior of the container to a bifurcation point; a first branch communicating with the flow line and extending from the bifurcation point to a first port; and a second branch communicating with the flow line and extending from the bifurcation point to a second port; wherein a peristaltic pump is provided in series in at least one of the flow line, the first branch, and the second branch, and a shut-off valve or another peristaltic pump is provided in series in at least another of the flow line, the first branch, and the second branch, so as to be able to intercept a predetermined volume of liquid between the bifurcation point and the first port or the second port; wherein the pore size of the capillary tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.2 mm to 2 mm.

[0009] Preferably, the container is a container open to the atmosphere, and the flow conduit extends from the interior of the container to the outside of the container.

[0010] Preferably, a first peristaltic pump or a third peristaltic pump is arranged in series in the flow pipeline and / or the first branch, and a second peristaltic pump or a stop valve is arranged in series in the second branch. The peristaltic pump and / or the stop valve work together to enable a predetermined volume of liquid between the bifurcation point and the first port to flow out of the first port or the second port. In the working state, the first peristaltic pump is used to suck the liquid in the container and make the liquid overflow from the first port; in the non-working state, the first peristaltic pump and the second peristaltic pump are both in the cut-off state.

[0011] Preferably, the first peristaltic pump is arranged in series in the first branch, the first stop valve is arranged in series in the flow pipeline, and the second stop valve or the second peristaltic pump is arranged in series in the second branch; or the first peristaltic pump is arranged in series in the first branch, the flow pipeline is a through pipe, and the second stop valve or the second peristaltic pump is arranged in series in the second branch; or the first peristaltic pump is arranged in series in the first branch, the third peristaltic pump is arranged in series in the flow pipeline, and the second peristaltic pump or the second stop valve is arranged in series in the second branch; or the third peristaltic pump is arranged in series in the flow pipeline, the first stop valve is arranged in series in the first branch, and the second peristaltic pump or the second stop valve is arranged in series in the second branch; or the first branch is a through pipe, the second peristaltic pump or the second stop valve is arranged in series in the second branch, and the first peristaltic pump is arranged in series in the flow pipeline.

[0012] Preferably, the first branch is a pipeline extending obliquely from the bifurcation point to the first port, preferably extending obliquely upward or obliquely downward.

[0013] Preferably, the first branch is provided with a liquid detector at a position adjacent to the first port, and the liquid of the predetermined volume between the bifurcation point and the first port is the liquid between the bifurcation point and the liquid detector; and / or the second branch is provided with a liquid detector at a position adjacent to the second port, and the liquid of the predetermined volume between the bifurcation point and the second port is the liquid between the bifurcation point and the liquid detector.

[0014] Preferably, the liquid between the bifurcation point and the liquid detector is the liquid from the bifurcation point to a predetermined offset point based on the liquid detector.

[0015] Preferably, the container is a closed container that is not open to the atmosphere, the closed container is connected to a pressurizing device for increasing the air pressure in the container, and the flow conduit extends from the interior of the container to the outside of the container.

[0016] Preferably, a first stop valve is arranged in series in the flow pipeline, and a third peristaltic pump is arranged in series in the second branch. The third peristaltic pump cooperates with the first stop valve and the pressurizing device to allow a predetermined volume of liquid between the bifurcation point and the first port to flow out of the first port or the second port.

[0017] Preferably, a second stop valve is provided in series in the first branch, and the third peristaltic pump also serves as the pressurizing device.

[0018] Preferably, the pressurizing device is a heater arranged in the container, which is used to heat the air in the container; or the pressurizing device includes an auxiliary container connected to the atmosphere, which is connected to the container through a fourth peristaltic pump to pressurize the liquid in the auxiliary container into the container; or the pressurizing device includes a fourth peristaltic pump, and the liquid container is connected to the external atmosphere through the fourth peristaltic pump.

[0019] Preferably, the first branch is provided with a liquid detector at a position adjacent to the first port, and the liquid of the predetermined volume between the bifurcation point and the first port is the liquid between the bifurcation point and the liquid detector; and / or the first port is provided with an extension section extending downward, preferably vertically downward.

[0020] Preferably, the liquid between the bifurcation point and the liquid detector is the liquid from the bifurcation point to a predetermined offset point based on the liquid detector.

[0021] Through the technical solution of the present application, the working characteristics of the capillary tube and the peristaltic pump and / or the stop valve can be utilized to achieve at least some of the following beneficial technical effects.

[0022] For example, by using a combination of a capillary tube and a peristaltic pump and / or a stop valve, and utilizing simple control of the peristaltic pump and the stop valve, the liquid to be metered can be easily filled into the selected capillary tube and accurately filled by overflow. At the same time, the overflow method can also eliminate bubbles that may be generated at the beginning of liquid filling, thereby achieving high-precision liquid filling with a small amount of liquid. In addition to being able to accurately determine the volume of the liquid to be measured, the technical solution of the present application can also achieve high-precision metering and rapid liquid filling, as well as transporting high-precision volumes of liquid to subsequent processing containers or processes.

[0023] For example, the flow path topology in the technical solution of the present application is very simple, the types of flow path devices required are relatively small, and the devices are simple and easy to mold and mass produce. Some flow paths even require only one device (peristaltic pump) in addition to the catheter, so the cost can be greatly reduced, the assembly is very simple during the production process, and daily maintenance and repair during use are also very convenient.

[0024] Furthermore, the technical solution of this application primarily utilizes (small and micro) peristaltic pumps and stop valves, which are currently widely used and produced in the industrial field, and uses inexpensive capillary tubes as constant-volume tubes. These components are not only inexpensive but also offer stable and reliable performance. Therefore, compared with traditional solutions, this solution can significantly reduce costs and achieve excellent reliability.

[0025] In addition, since in the technical solution of the present application, as described above, high-precision constant volume metering can be achieved by utilizing the flow path design, preferably, a peristaltic pump can also be utilized (since the peristaltic pump tube is directly connected to the capillary tube, the peristaltic pump can more easily eliminate the dead volume interference problem of the residual liquid compared to the stop valve) to achieve a higher-precision liquid filling operation.

[0026] In addition, in the present application, not only can the expansion and modular combination of various flow path schemes be conveniently realized, but also a "concurrent micro-equivalent rapid liquid inlet technology" similar to the "clip loading" type can be realized in the scheme of some combined flow paths: in the traditional sequential liquid inlet method (such as the "sequential injection" liquid inlet technology), since there can usually be only one constant volume metering device and one peristaltic pump, the water sample or reagent must be driven into the constant volume metering device in turn by the peristaltic pump, and finally pushed or sucked into the designated container or pipeline; in the preferred embodiment of the present application, the "concurrent micro-equivalent rapid liquid inlet technology" of "pre-loading of medicine" (such as the application flow path) is used. Figure 21-24 、 Figure 33-42 The water sample and various reagents can be pre-filled in their respective branches at the same time, and then driven simultaneously or sequentially by the pumps on each branch, or sequentially by the pump in the trunk line, and injected into the reaction vessel, which greatly saves the overall time for completing the metering of all reagents and the subsequent cleaning.

[0027] Furthermore, the "sequential injection" liquid feeding technology requires that the water sample or reagent be first pumped into the quantitative tube for transfer and constant volume, and then the water sample or reagent in the quantitative tube be pumped into a predetermined container (such as a colorimetric tube). After the detection is completed, the discharge of waste liquid also requires a process opposite to it. Such operation is time-consuming and easily increases the risk of residual liquid in the flow path. In the preferred embodiment of the present application, the flow path does not need to be provided with a liquid storage unit. The flow path scheme in each combined flow path can independently allow the liquid to be tested (such as a water sample) and the reagent to directly enter the colorimetric tube leading to the reaction vessel. The work of liquid delivery and volume measurement can be completed at the same time, and the discharge is also simpler, only needing to discharge the liquid continuously at high speed to the waste liquid port. Moreover, due to the improvement of measurement accuracy, the volume of the liquid fed by the present application is greatly reduced, and the flow path stroke is also greatly shortened. Therefore, compared with the traditional method, this will greatly shorten the liquid feeding time and improve work efficiency; and due to the reduction of core components such as plunger pumps and metering quantitative tubes, not only the cost is greatly reduced, but also the volume of the device can be reduced to achieve miniaturization and portability.

[0028] Other features and advantages of the present application will be described in detail in the subsequent detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The accompanying drawings are used to provide a further understanding of the present application and constitute a part of the specification. Together with the following detailed description, they are used to explain the present application but do not constitute a limitation of the present application. In the accompanying drawings:

[0030] Figures 1A to 1E as well as Figures 2 to 10 They are schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquid according to the present application.

[0031] Figures 11A to 11C Schematic diagram of a type A combined flow path of a device for quantitatively processing liquid according to the present application.

[0032] Figure 12 Schematic diagram of a P-type combined flow path of a device for quantitatively processing liquid according to the present application.

[0033] 13A to 13D Schematic diagram of a type B combined flow path of a device for quantitatively processing liquid according to the present application. 14A to 14C Schematic diagram of a C-type combined flow path of a device for quantitatively processing liquid according to the present application. 15A to 15D Schematic diagram of a BC-type combined flow path of a device for quantitatively processing liquid according to the present application. 16A to 16B Schematic diagram of an H-type combined flow path of a device for quantitatively processing liquid according to the present application. Figures 17 to 43 They are schematic diagrams of various reaction flow paths of the device for quantitatively processing liquid according to the present application. Figure 44 A schematic diagram illustrating the principle of expressing the technical advantages of the capillary tube used in the technical solution of the present application when in use. DETAILED DESCRIPTION

[0034] In the technical solution of the present application, the focus is on describing the basic flow paths, combinations of basic flow paths, and various application flow paths of the device for quantitatively processing liquids. It can be understood that in actual engineering applications, various liquid flow control methods can be achieved by combining the flow path scheme of the technical solution of the present application under the control of various components by a computer system (such as an industrial computer, a single-chip microcomputer, and other control units). The selection of the control unit and the program design can be selected according to the actual working conditions.

[0035] As described above, the technical solutions of this application can be applied to various technical fields involving liquid processing and / or analysis, such as the medical field, the food field, and laboratory analysis, but are particularly suitable for water quality testing and analysis in the field of environmental protection. For example, the technical solutions of this application are particularly suitable for water quality analyzers.

[0036] The following describes the specific embodiments of the present application in detail with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present application and are not intended to limit the present application.

[0037] I. Definition of Terms

[0038] 1. Thin tube

[0039] In the technical solution of this application, the flow path utilizes a capillary tube design, wherein the pore diameter of the capillary tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, more preferably 0.2 mm to 2 mm, and even more preferably 0.5 mm to 1.6 mm. Furthermore, the capillary tube generally has a uniform pore diameter throughout the flow path; however, different pore diameters may be designed within the permitted accuracy range or depending on the location of components (such as a peristaltic pump or shut-off valve).

[0040] The material of the capillary tube includes but is not limited to various rubbers, plastics or metals, etc. Commonly used tubes include silicone rubber tubes, fluororubber tubes, polytetrafluoroethylene tubes, etc.

[0041] In the technical solution of the present application, the thin tube design is adopted for the following reasons.

[0042] As mentioned above, the use of a capillary tube (combined with a simple control of a peristaltic pump and / or a stop valve) can not only achieve high-precision constant volume under micro-liquid volume, but also achieve high-precision micro-liquid inlet (such as 0.1-2 ml). For example, if a capillary tube with a pore size of 0.5 mm and a length of 500 mm is used for constant volume, the technical solution of the present application can easily achieve constant volume measurement of approximately 100 microliters (0.1 ml) of sewage with an accuracy of ±2 microliters, and then the high-precision constant volume liquid can be transported out without residue. In addition, due to the use of a capillary tube, it is possible to use a smaller volume of liquid sample for processing and subsequent detection work, which greatly reduces the cost of consumed reagents.

[0043] More importantly, in the field of online monitoring under harsh working conditions, the use of the above-mentioned thin tubes (optimally with an inner diameter of 0.5-1.6 mm) offers three significant advantages. First, the thin tubes are easy to plug in and out for maintenance, and the cost of regular replacement is very low, which is particularly important for online monitoring instruments under harsh working conditions. Second, for coarsely filtered liquids, this tube diameter can essentially prevent pipe blockage caused by suspended matter or impurities in the liquid, ensuring the stability of the flow path. Third, when the tube is sufficiently thin, its inner diameter will be smaller than the height of the liquid droplets formed inside the tube due to surface tension and infiltration. At this point, the liquid will naturally converge and seal the thin tube. Driven by the pump, the liquid can be slowly delivered to the target container, thus avoiding or reducing the amount of liquid retention or residual in the pipeline that can affect accuracy. If the aperture of the conduit is designed to be too large, the liquid remaining on the inner wall of the conduit after the liquid passes through the conduit will be difficult to be removed by the gas blown in from the outside, because in this case the maximum radial size of the droplets of the residual liquid is difficult to reach the height of the inner diameter of the conduit. Therefore, even if the gas is introduced, it is difficult to more thoroughly remove the residual liquid on the inner wall of the conduit due to the existence of the above-mentioned gaps. Figure 44 In the technical solution of the present application, by selecting the above-mentioned pore size range of the capillary tube, the maximum radial size of the droplets formed by the liquid remaining on the inner wall of the tube can reach or exceed the height of the inner diameter of the tube (such as Figure 44 As shown), the introduced fluid (such as liquid or gas) can be used to more thoroughly remove the residual liquid on the inner wall of the pipeline, while also avoiding the defect that the impurities in the liquid to be measured easily block the pipeline in the field of online monitoring under harsh working conditions.

[0044] It is understandable that although the present application emphasizes the use of thin tubes, this does not mean that other non-thin tube devices that can form various complex combination channels in the present application are excluded, such as the combined use of tubes with larger pore diameters. Under the condition that it does not affect the realization of the invention purpose of the present application, tubes with larger pore diameters can also be partially used, such as thick constant volume tubes when it is necessary to constant volume for a conventional volume of more than 2 ml (see Figure 29-32) and a thick tube connected to the wastewater outlet. This not only allows for flexible wiring and low costs, but also facilitates maintenance during later use. Furthermore, while the capillary tubes described above are described using catheters as an example, it is understood that, provided the aperture size ranges described above are met, the capillary tubes in this application are not limited to catheters and may also take other forms, such as organic manifolds, microfluidic chip grooves, etc.

[0045] 2. Peristaltic pump

[0046] In the technical solution of this application, a peristaltic pump is a broad definition of a device or device combination that has the function of a peristaltic pump. Unless otherwise specified, it generally refers to a device or device combination that can drive liquid in both directions (sometimes only uses its function of driving in a certain direction) and can cut off and close the pipeline when stationary. The above-mentioned broad peristaltic pump includes but is not limited to the following specific devices or device combinations: a peristaltic pump in a narrow sense; a series combination of a stop valve and a pump that can drive fluid in both directions (sometimes only uses its function of driving in a certain direction) or a pump group (such as a combination of several diaphragm pumps, centrifugal pumps, etc.), etc.

[0047] 3. Stop valve

[0048] In the technical solution of the present application, the stop valve is a broad definition of a device or combination of devices that has the function of shutting off a certain pipeline, including but not limited to the following specific devices: diaphragm-type two-way stop valve; clamp-type two-way stop valve (referred to as clamp valve); peristaltic pump in a narrow sense (equivalent to closing when stationary and opening when rotating); rotary switching two-way or multi-way valve, etc.

[0049] 4. N-choose-1 multi-channel valve (where N is a natural number greater than or equal to 2)

[0050] In the technical solution of this application, the N-to-1 multi-channel valve is a broad definition of a device or device combination, which has a common port and N distribution ports. Through a control signal, the common port can uniquely connect to one of the N distribution ports or shut off all of them. The above-mentioned broad N-to-1 multi-channel valve includes but is not limited to the following specific devices or device combinations: a valve group consisting of N shut-off valves connected to the same common port; a multi-channel rotary switching valve (see Figure 35 ); other valve groups consisting of multiple stop valves and multiple multi-channel switching valves, etc.

[0051] 2. Basic flow path scheme

[0052] like Figures 1A to 1E as well as Figures 2 to 10 As shown, the present application provides a device for quantitatively processing liquid (basic flow path scheme), the device comprising:

[0053] a container P for containing the liquid to be extracted; and

[0054] A capillary tube comprising:

[0055] A through-flow conduit 10 extending from the interior of the container P to a bifurcation point a;

[0056] a first branch 11 , which is in communication with the through-flow conduit 10 and extends from the bifurcation point a to the first port K1 ; and

[0057] a second branch 12 , which is in communication with the through-flow conduit 10 and extends from the bifurcation point a to a second port K2 ;

[0058] A peristaltic pump B1 is arranged in series in at least one of the flow pipeline 10, the first branch 11 and the second branch 12, and a shut-off valve F1, F2 or another peristaltic pump B2 is arranged in series in at least the other of the flow pipeline 10, the first branch 11 and the second branch 12, so as to intercept a predetermined volume of liquid between the bifurcation point a and the first port K1 or the second port K2, wherein the aperture of the capillary is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.2 mm to 2 mm.

[0059] The container P is used to hold the liquid to be processed or analyzed. The container P can be made of various suitable materials, such as glass or plastic. The capacity of the container P can be selected and designed based on the specific working conditions; typically, the maximum capacity of the container P is 100-2000 ml. Furthermore, the container P can be open, i.e., open to the atmosphere, or closed, i.e., not directly open to the atmosphere. These two configurations are described in detail in the following embodiments.

[0060] One end of the through-flow conduit 10 is located in the container P and extends outward to a bifurcation point a. From the bifurcation point a, the through-flow conduit 10 is divided into a first branch 11 and a second branch 12. The first branch 11 has a first port K1, and the second branch 12 has a second port K2.

[0061] In order to accurately obtain the liquid sample to be processed or tested, a peristaltic pump B1 is installed in series in at least one of the flow line 10, the first branch 11, and the second branch 12. A shut-off valve F1, F2, or another peristaltic pump B2 is installed in series in at least another of the flow line 10, the first branch 11, and the second branch 12, so as to be able to intercept a predetermined volume of liquid between the bifurcation point a and the first port K1 or the second port K2. Specifically, a peristaltic pump is installed in series in at least one of the flow line 10, the first branch 11, and the second branch 12, and a shut-off valve or another peristaltic pump is installed in at least another of the three. The peristaltic pump serves as a power source for sucking or pushing liquid. When the peristaltic pump rotates, it can extract liquid from the container P and also pump out the liquid after accurate volume is reached. At the same time, when the peristaltic pump stops rotating, it can also serve as a shut-off function. Therefore, the cooperation of the peristaltic pump and the shut-off valve can accurately shut off a predetermined volume of liquid sample between the bifurcation point a and the first port K1 or the second port K2, thereby obtaining a precise liquid sample.

[0062] The technical solution based on the innovative concept of the present application has many preferred implementation methods, mainly with multiple permutations and combinations between the flow line 10, the first branch 11, and the second branch 12, and the peristaltic pump and the stop valve. Specifically, one of the peristaltic pump, the stop valve, and the component-free setting (through pipe) can be selected from the flow line 10, the first branch 11, and the second branch 12, so there are a total of 3*3*3=27 combinations. At the same time, it is necessary to exclude the combination in which the flow line 10, the first branch 11, and the second branch 12 are all stop valves or are all component-free (because the combination in which all three are provided with stop valves or no components is not applicable), so there are a total of 25 combinations. These combinations are all within the scope of the present application.

[0063] The following will describe the structural composition, connection relationship, operation process and technical advantages of each preferred embodiment shown in the accompanying drawings.

[0064] Figures 1A to 1E as well as Figures 2 to 10 The main description is of the various implementation methods of a single device. For the convenience of explanation, this application agrees on the subsequent naming definitions of various basic flow paths. The names are divided into two parts, connected by a "-" sign in the middle. For example, "1A-Basic" means Figure 1A The basic flow path shown, "2-Basic" means Figure 2 The basic flow path shown in the figure can be deduced by analogy. In addition, due to Figures 1A to 1E There are five variations of the basic type (the principles are the same or similar), so we use "1-basic type" to represent Figures 1A to 1EThe five basic flow paths shown are generally explained using "1A-Basic" as an example.

[0065] Next, the structural composition and connection relationship of each type of basic flow path are explained. For the sake of brevity, this application only schematically draws part of the basic flow path for the description of the basic type.

[0066] like Figures 1A to 1E as well as Figures 2 to 6 As shown, the basic flow path can have various connection forms.

[0067] For example Figure 1A and Figure 1B As shown, the first peristaltic pump B1 is connected in series in the first branch 11 , the first stop valve F1 is connected in series in the flow pipeline 10 , and the second stop valve F2 or the second peristaltic pump B2 is connected in series in the second branch 12 .

[0068] For example Figure 1C and Figure 1D As shown, the first peristaltic pump B1 is arranged in series in the first branch 11 , the third peristaltic pump B3 is arranged in series in the flow pipeline 10 , and the second peristaltic pump B2 or the second shut-off valve F2 is arranged in series in the second branch 12 .

[0069] For example Figure 1E As shown, the third peristaltic pump B3 is connected in series in the flow pipeline 10, the first stop valve F1 is connected in series in the first branch 11, and the second peristaltic pump B2 (not shown) or the second stop valve F2 is connected in series in the second branch 12.

[0070] For example Figure 2 and Figure 3 As shown, the first peristaltic pump B1 is provided in series in the first branch 11 , the through-flow pipeline 10 is a through-tube, and the second shut-off valve F2 or the second peristaltic pump B2 is provided in series in the second branch 12 .

[0071] For example Figures 4 to 6 As shown, the first branch 11 is a through pipe, the second branch 12 is provided with the second peristaltic pump B2 or the second shut-off valve F2 in series, and the through flow pipeline 10 is provided with the first peristaltic pump B1 in series.

[0072] Below Figures 1A to 1E as well as Figures 2 to 10 The basic flow path shown in Figure 2 is described in more detail.

[0073] Implementation Method 1

[0074] like Figures 1A to 1EAs shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0075] Container P is used to hold the liquid to be extracted and is open to the atmosphere. A capillary flow conduit 10 extends from the interior of container P outward (preferably upward) to a bifurcation point a. At this bifurcation point a, flow conduit 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from this bifurcation point a to a first port K1, and the second branch 12 extends from this bifurcation point a to a second port K2.

[0076] Each of the flow pipe 10, the first branch 11, and the second branch 12 is provided with a peristaltic pump or a shut-off valve in series, and at least one of the flow pipe 10, the first branch 11, and the second branch 12 is provided with a peristaltic pump in series. The following are descriptions of several different "1-basic" flow paths:

[0077] like Figure 1A In the basic flow path of “1A-Basic Type” shown, a first shut-off valve F1 is arranged in series in the flow pipeline 10 , a first peristaltic pump B1 is arranged in series in the first branch 11 , and a second shut-off valve F2 is arranged in series in the second branch 12 .

[0078] Figure 1A The operation of the illustrated embodiment is as follows.

[0079] First, open the first shut-off valve F1 and keep the second shut-off valve F2 closed. Then, rotate the first peristaltic pump B1 clockwise (based on the orientation shown in the figure, but not limiting this application). At this point, the liquid in the container P enters the flow line 10 under the pumping of the first peristaltic pump B1, passes through the first shut-off valve F1 and the first peristaltic pump B1, and then overflows and is discharged through the first port K1.

[0080] Next, close the first shutoff valve F1, open the second shutoff valve F2, and rotate the first peristaltic pump B1 counterclockwise. Air then enters through the first port K1, allowing the constant volume of liquid in the section of tube between the bifurcation point a and the first port K1 to be withdrawn through port K2. Alternatively, rotate the first peristaltic pump B1 clockwise, allowing air to enter through the second port K2, allowing the constant volume of liquid in the section of tube between the bifurcation point a and the first port K1 to be withdrawn through the first port K1.

[0081] like Figure 1B The basic flow path of "1B-Basic" shown is the same as Figure 1AThe main difference of the "1A-Basic" basic flow path shown is that the second stop valve F2 is replaced by the second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can play a shut-off role. Using the liquid inlet operation process of the "1A-Basic" flow path, the liquid can be measured and fixed in the first branch or the second branch. When it is necessary to take out the liquid with a fixed volume in a section of the tube between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be made to move in the same direction but at different speeds to take out the above liquid from the first port K1 or the second port K2. In this solution, the devices on the first branch 11 and the second branch 12 are preferably designed to be interchangeable, but they can also be different peristaltic pumps.

[0082] like Figure 1C The basic flow path of "1C-Basic" shown is the same as Figure 1A The main difference of the "1A-Basic" basic flow path shown is that the first shut-off valve F1 is replaced with the third peristaltic pump B3. Therefore, when the third peristaltic pump B3 is stationary, it can act as a shut-off valve. Using the liquid inlet operation process of the "1A-Basic" flow path, liquid can be metered and fixed in the first or second branch pipe. When it is necessary to remove the fixed volume of liquid in the section of pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the third peristaltic pump B3 can be operated in the same direction but at different speeds to remove the liquid from the first port K1 or the second port K2.

[0083] like Figure 1D The basic flow path of "1D-Basic" shown is the same as Figure 1A The main difference of the "1A-Basic" basic flow path shown is that the first stop valve F1 and the second stop valve F2 are replaced by the third peristaltic pump B3 and the second peristaltic pump B2, respectively. Therefore, when the second peristaltic pump B2 or the third peristaltic pump B3 is stationary, it can play a shutoff role. Using the liquid inlet operation process of the "1A-Basic" flow path, the liquid can be measured and fixed in the first branch pipe or the second branch pipe. When it is necessary to remove the liquid with a fixed volume in a section of the pipe between the bifurcation point a and the first port K1 or the second port K2, the first peristaltic pump B1 and the second peristaltic pump B2 can be made to move in the same direction but at different speeds to remove the above liquid from the first port K1 or the second port K2.

[0084] like Figure 1E In the basic flow path of “1e-basic type” shown, a third peristaltic pump B3 is arranged in series in the flow pipeline 10 , a first stop valve F1 is arranged in series in the first branch 11 , and a second stop valve F2 is arranged in series in the second branch 12 .

[0085] Figure 1E The operation of the illustrated embodiment is as follows.

[0086] First, open the first shut-off valve F1 and keep the second shut-off valve F2 closed. Then, rotate the third peristaltic pump B3 counterclockwise (based on the orientation shown in the figure, but not limiting this application). At this point, the liquid in the container P, pumped by the third peristaltic pump B3, enters the flow line 10, passes through the third peristaltic pump B3 and the first shut-off valve F1, and overflows and is discharged through the first port K1.

[0087] Then, the first shut-off valve F1 is opened, the first peristaltic pump B1 remains stationary, and the second shut-off valve F2 is opened. At this point, air enters through the first port K1, and the liquid in the section of the tube between the bifurcation point a and the first port K1, which has a constant volume, is withdrawn from the second port K2 under the action of gravity. Similarly, due to the design of the capillary tube, when the third peristaltic pump B3 remains stationary and the second shut-off valve F2 is closed, the liquid in the section of the tube between the bifurcation point a and the first port K1 will not flow downward on its own. Instead, it will flow out under the action of gravity only after the second shut-off valve F2 is opened.

[0088] As can be seen from the above description, since the peristaltic pump has a bidirectional rotational working state, it can be used to both aspirate the liquid in the container P and discharge the liquid from the corresponding port. The characteristics of the basic flow paths of Figure 1 are: in the three branches (the through-flow pipeline, the first branch, and the second branch), each branch must be connected in series with at least one peristaltic pump or stop valve, and at least one branch must be connected in series with a peristaltic pump.

[0089] according to Figures 1A to 1E The illustrated embodiment can extract a predetermined volume of liquid sample with high efficiency, and the volume of the obtained liquid sample is relatively accurate. Furthermore, due to the small aperture of the capillary tube, the volume of the liquid sample extracted is also relatively small. By adjusting the lengths of the first branch 11 and the second branch 12, the volume of liquid to be extracted can be determined. This method is also applicable to the other embodiments described below.

[0090] Implementation Method 2

[0091] like Figure 2 As shown, the basic flow path structure and connection relationship of the device for quantitatively processing liquid are as follows.

[0092] Container P is used to hold the liquid to be extracted and is open to the atmosphere. A capillary flow conduit 10 extends from the interior of container P outward (preferably upward) to a bifurcation point a. At this bifurcation point a, flow conduit 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from this bifurcation point a to a first port K1, and the second branch 12 extends from this bifurcation point a to a second port K2.

[0093] like Figure 2 As shown, no components are arranged in series in the flow line 10 , a first peristaltic pump B1 is arranged in series in the first branch 11 , and a second shut-off valve F2 is arranged in series in the second branch 12 .

[0094] Figure 2 The operation of the illustrated embodiment is as follows.

[0095] First, keep the second shut-off valve F2 closed, and then rotate the first peristaltic pump B1 clockwise (based on the orientation shown in the figure, but not limiting this application). At this point, the liquid in the container P enters the flow line 10 under the pumping of the first peristaltic pump B1, passes through the first peristaltic pump B1, and then overflows and is discharged through the first port K1.

[0096] Then, the first peristaltic pump B1 remains stationary (equivalent to the shutoff state), and the second shutoff valve F2 is opened. Air then enters through the second port K2, causing the liquid between the bifurcation point a and the container P to flow back into the container P under the action of gravity. However, the liquid in the section of the tube between the bifurcation point a and the first port k1, which has a constant volume, remains stationary due to the shutoff of the peristaltic pump B1 and the liquid's surface tension and inability to expand or contract.

[0097] Subsequently, the first peristaltic pump B1 is rotated clockwise. Since the resistance at the second port K2 is smaller than the gravity that the liquid in the tube in the container P has to overcome when it rises, air enters from the second port K2, and the liquid with a constant volume in the section of the tube between the bifurcation point a and the first port k1 is taken out from the first port K1.

[0098] From the above description, it can be seen that by utilizing the aperture characteristics of the capillary tube, combined with the physical effects of gravity, the non-expandability of the liquid and surface tension, the technical solution of the present application can be implemented at a relatively low cost.

[0099] Implementation Method 3

[0100] like Figure 3 The preferred embodiment 3 shown is Figure 2 The main difference in the second embodiment shown is that the second shut-off valve F2 is replaced with a second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can function as a shut-off valve. To remove a constant volume of liquid from the section of tube between the bifurcation point a and the first port k1, the first and second peristaltic pumps B1 and B2 can be operated in the same direction but at different speeds to remove the liquid from either the first port K1 or the second port K2.

[0101] Implementation Method 4

[0102] like Figure 4As shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0103] Container P is used to hold the liquid to be extracted and is open to the atmosphere. A capillary flow conduit 10 extends from the interior of container P outward (preferably upward) to a bifurcation point a. At this bifurcation point a, flow conduit 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from this bifurcation point a to a first port K1, and the second branch 12 extends from this bifurcation point a to a second port K2.

[0104] like Figure 4 As shown, a first peristaltic pump B1 is arranged in series in the flow line 10 , no components are arranged in series in the first branch 11 , and a second peristaltic pump B2 is arranged in series in the second branch 12 .

[0105] Figure 4 The operation of the illustrated embodiment is as follows.

[0106] First, keep the second peristaltic pump B2 stationary, then rotate the first peristaltic pump B1 counterclockwise (based on the orientation shown in the figure, but not limiting this application). At this point, the liquid in the container P enters the flow line 10 under the pumping of the first peristaltic pump B1, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows and is discharged through the first port K1.

[0107] Then, the first peristaltic pump B1 remains stationary (equivalent to the off state), while the second peristaltic pump B2 rotates counterclockwise. Air then enters through the first port K1, causing the constant volume of liquid in the section of the tube between the bifurcation point a and the first port k1 to be withdrawn through the second port K2. Alternatively, if the second peristaltic pump B2 rotates clockwise, air enters through the second port K2, causing the constant volume of liquid in the section of the tube between the bifurcation point a and the first port k1 to be withdrawn through the first port K1.

[0108] It can be seen from the above description that the stationary cut-off working condition and the bidirectional rotating working condition of the two peristaltic pumps can be utilized to intercept a predetermined section of liquid sample from the first port K1 or the second port K2 as needed.

[0109] Implementation Methods Five and Six

[0110] like Figure 5 and Figure 6 As shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0111] The container P is used to contain the liquid to be extracted, and the container P is a container open to the atmosphere.

[0112] The through-flow conduit 10 of the capillary extends from the interior of the container P to the outside of the container P (preferably upwards) and to a bifurcation point a.

[0113] At the bifurcation point a, the flow conduit 10 is divided into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2. The first branch 11 extends obliquely from the bifurcation point a to the first port K1, either upward or downward. The angle of inclination of the inclined conduit relative to the horizontal plane can be selected and designed based on the specific application conditions, such as between 30 and 90 degrees, or preferably approximately 45 degrees.

[0114] like Figure 5 and Figure 6 As shown, a first peristaltic pump B1 is arranged in series in the flow line 10 , no components are arranged in series in the first branch 11 , and a second shut-off valve F2 is arranged in series in the second branch 12 .

[0115] Figure 5 and Figure 6 The operation of the illustrated embodiment is as follows.

[0116] First, keep the second shut-off valve F2 closed. Then, rotate the first peristaltic pump B1 counterclockwise (based on the orientation shown in the figure, but not limiting this application). At this point, the liquid in the container P, pumped by the first peristaltic pump B1, enters the flow line 10, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows and is discharged through the first port K1.

[0117] Then, in Figure 5 In the illustrated operating condition, the first peristaltic pump B1 remains stationary, and the second shut-off valve F2 is open. Air enters through the second port K2, while the liquid, which holds a constant volume within the section of tubing between bifurcation point a and the first port K1, flows out of the first port K1 under the action of gravity. In this scenario, due to the design of the capillary tube, when the first peristaltic pump B1 remains stationary and the second shut-off valve F2 is closed, the liquid within the section of tubing between bifurcation point a and the first port K1 does not flow downward on its own. Instead, it flows out under the action of gravity only after the second shut-off valve F2 is opened.

[0118] And in Figure 6In the illustrated operating condition, the first peristaltic pump B1 remains stationary, and the second shut-off valve F2 is open. Air enters through the first port K1, and the liquid, which holds a constant volume within the section of tubing between bifurcation point a and the first port K1, flows out through the second port K2 under the action of gravity. Similarly, due to the design of the capillary tube, when the first peristaltic pump B1 remains stationary and the second shut-off valve F2 is closed, the liquid, which holds a constant volume within the section of tubing between bifurcation point a and the first port K1, does not flow downward on its own. Instead, it flows out under the action of gravity only after the second shut-off valve F2 is opened.

[0119] From the above description, it can be seen that simply utilizing the static cut-off function of the peristaltic pump and the inclined design of the branch, combined with the design of the capillary tube, it is possible to conveniently intercept and collect liquid samples of an accurate volume using gravity.

[0120] The above embodiments do not exhaust the various combinations under the technical solution of this application. For example, in different embodiments, when no flow path device is provided, the branch and the flow conduit can be formed into a through-tube form. In some of the above embodiments, the flow conduit 10 can be designed as a through-tube; while in other embodiments, the first branch 11 and / or the second branch can be designed as a through-tube. The working process of the embodiments not shown in the drawings of the specification of this application can naturally refer to the detailed description of the structure and working process of the above-mentioned various embodiments.

[0121] In the above embodiments, the container P is a container that is open to the atmosphere. However, in some working conditions that require strong corrosive reagents, volatile reagents or water samples, the container P is designed to be a closed container that is not directly open to the atmosphere, such as Figures 7 to 10 As shown. This closed container can be obtained by first injecting liquid into the container and then sealing it. The closed container is connected to a pressurizing device for increasing the air pressure in the container, and the flow pipe 10 extends from the inside of the container P to the outside of the container P. Figures 7 to 10 This is described in detail.

[0122] Implementation Method Seven

[0123] like Figure 7 As shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0124] The container P is used to contain the liquid to be extracted, and the container P is a closed container that is not directly connected to the atmosphere.

[0125] A capillary flow conduit 10 extends from the interior of the container P outward from the container P (preferably upward) to a bifurcation point a. At this bifurcation point a, the flow conduit 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0126] like Figure 7 As shown, a first shutoff valve F1 is arranged in series in the flow line 10 , a second shutoff valve F2 is arranged in series in the first branch 11 , and a third peristaltic pump B3 is arranged in series in the second branch 12 .

[0127] Figure 7 The operation of the illustrated embodiment is as follows.

[0128] First, the first shut-off valve F1 is opened and the second shut-off valve F2 is closed. The third peristaltic pump B3 rotates clockwise, allowing air to enter the container P from the second port K2 through the first shut-off valve F1, thereby pressurizing the container. Therefore, the third peristaltic pump B3 now functions as a pressurizing device.

[0129] Next, close the first shut-off valve F1, keeping the third peristaltic pump B3 stationary (off). Then, open the first shut-off valve F1 and the second shut-off valve F2. At this point, the liquid in the container P, under the action of internal pressure, enters the flow line 10, passes through the first shut-off valve F1 and the second shut-off valve F2, and overflows and is discharged through the first port K1.

[0130] Then, close the first shut-off valve F1 and rotate the third peristaltic pump B3 clockwise, causing air to enter through the second port K2 and push the constant volume of liquid in the section of tube between the bifurcation point a and the first port k1 out of the first port K1. Alternatively, rotate the third peristaltic pump B3 counterclockwise, causing air to enter through the first port K1 and push the constant volume of liquid in the section of tube between the bifurcation point a and the first port k1 out of the second port K2.

[0131] Implementation Method Eight

[0132] like Figure 8 As shown, the structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0133] The container P is used to contain the liquid to be extracted, and the container P is a closed container that is not directly connected to the atmosphere. The pressurizing device is a heater 30 provided in the container, and the heater is used to heat the air in the container.

[0134] A capillary flow conduit 10 extends from the interior of the container P outward from the container P (preferably upward) to a bifurcation point a. At this bifurcation point a, the flow conduit 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0135] like Figure 8 As shown, a first shut-off valve F1 is arranged in series in the flow line 10 , no components are arranged in series in the first branch 11 , and a third peristaltic pump B3 is arranged in series in the second branch 12 .

[0136] Figure 8 The operation of the illustrated embodiment is as follows.

[0137] First, the first shutoff valve F1 is opened, and the third peristaltic pump B3 is stationary. Heater 30 heats and pressurizes the air within container P. Under the influence of internal pressure, the liquid within container P enters flow conduit 10, passes through the first shutoff valve F1 and bifurcation point a, and overflows and is discharged through the first port K1.

[0138] Then, close the first shut-off valve F1 and rotate the third peristaltic pump B3 clockwise, causing air to enter through the second port K2 and push the constant volume of liquid in the section of tube between the bifurcation point a and the first port K1 out of the first port K1. Alternatively, rotate the third peristaltic pump B3 counterclockwise, causing air to enter through the first port K1 and push the constant volume of liquid in the section of tube between the bifurcation point a and the first port K1 out of the second port K2.

[0139] In this embodiment, a cooler is preferably provided. After the predetermined volume of liquid sample is intercepted, the air in the container P can be cooled so that the liquid between the bifurcation point a and the port 101 of the flow line 10 can flow back into the container P, thereby facilitating the next liquid collection operation.

[0140] Implementation Methods Nine and Ten

[0141] See also Figure 9 and Figure 10 The ninth embodiment shown is the Figure 8 The main difference of the eighth embodiment shown is the pressurizing device.

[0142] In the tenth embodiment, if Figure 10 As shown, the pressurizing device includes a fourth peristaltic pump B4, and the liquid container P is directly connected to the external atmosphere through the fourth peristaltic pump B4. In the ninth embodiment, as shown in FIG. Figure 9As shown, the fourth peristaltic pump B4 can be connected to another auxiliary container P2 (containing the same liquid) that is open to the atmosphere to pressurize the liquid in the auxiliary container P2 into the container P to achieve pressurization.

[0143] For other working processes of intercepting a predetermined section of a fixed volume of liquid sample, reference may be made to Implementation Example 8.

[0144] The above embodiments do not exhaust the various combinations of the technical solutions of this application. For example, a peristaltic pump may be provided in series with the flow conduit 10, and a peristaltic pump or a shut-off valve may be provided in series with the second branch or the first branch. The peristaltic pump cooperates with the shut-off valve and the pressurizing device to allow a predetermined volume of liquid sample between the bifurcation point a and the first port K1 to flow out of the first port K1 or the second port K2.

[0145] The above describes the embodiments of the closed container, and each of the above embodiments can be selected and applied according to specific working conditions.

[0146] In addition, as shown in the figure, in a preferred embodiment, a liquid detector S is provided at a position adjacent to the first port K1 on the first branch 11, and the predetermined volume of liquid between the bifurcation point a and the first port K1 is the liquid between the bifurcation point a and the liquid detector S. The liquid detector S can be any sensor suitable for determining whether liquid exists, so as to determine whether liquid exists or has reached the position where the liquid detector S is located.

[0147] By setting up a liquid detector S, it is not necessary to determine the volume capacity by forcing the liquid to flow out of the first port K1. That is to say, in an embodiment in which a liquid detector S is provided, a liquid sample can be intercepted from the bifurcation point a to a more flexible volume end near the liquid detector S. At the same time, since there is no need for liquid overflow, waste can be prevented. Further preferably, the liquid between the bifurcation point a and the liquid detector S is the liquid from the bifurcation point a to a predetermined offset point based on the liquid detector S, and the distance of the predetermined offset point can be controlled by the algorithm of the flow path liquid inlet (for example, it is related to the flow rate of the liquid, or whether there are bubbles in the liquid, or the length and volume of the bubbles), thereby achieving error compensation for various uncertain factors during liquid inlet (bubbles, liquid flow rate, pulsating liquid inlet error during peristaltic pump liquid inlet, etc.) to obtain a more accurate predetermined volume of liquid sample. It is understandable that in the technical solution of the present application, a liquid detector S can also be provided at a position adjacent to the second port K2 of the second branch 12. It can be understood that the technical features of the liquid detector S can be applied to various basic flow paths in this application, and are not limited to the implementation methods illustrated in the drawings of this application specification.

[0148] Preferably, the first port K1 is provided with a downward extending section (not shown), preferably extending vertically downward, to ensure that when the liquid overflows from the capillary outlet, the interference of uncertain factors on the quantitative interception of volume is avoided, thereby further improving the accuracy of volume determination.

[0149] Figures 1A to 1E as well as Figures 2 to 10 The following primarily describes various embodiments of basic flow paths. According to further preferred embodiments, individual basic flow paths can be appropriately arranged and combined to accommodate multiple containers P containing the same or different liquids. The following describes in detail a combined device solution formed by combining individual basic flow paths.

[0150] In addition, it can be understood that the main advantage of the above-mentioned basic flow path over traditional technology is that the flow path solution using a thin tube combined with a peristaltic pump and / or a stop valve can achieve high-precision volume determination and push it out, and it has high work efficiency, very low cost and can be flexibly combined (in series, serial or parallel, parallel).

[0151] 3. Combined flow path solution

[0152] As described above, each basic flow path includes five elements: a first port K1, a second port K2, a first branch 11, a second branch 12, and a bifurcation point a. Depending on the operating conditions and fluid inlet requirements, the various basic flow paths described above can be combined to create different combined flow path solutions.

[0153] For ease of explanation, this application stipulates the subsequent naming definitions for various access methods of various basic flow paths to the main flow branch. The name is divided into three parts, connected by a "-" sign in the middle, such as "1-K1-B". The specific naming definitions are as follows:

[0154] The first part of the name indicates the basic flow path used, such as Figures 1A to 1E If one of the basic flow paths is used, the name of this part is "1". Figure 2 For the basic flow path of Figure 1, the name of this part is "2", and so on. It should be noted that since the basic flow path in Figure 1 has five variants, but the principles are the same, we use the "1A-Basic" flow path as an example. In the combined flow paths, we generally use "1" to unify the naming unless otherwise specified.

[0155] The second part of the name identifies the connection point between the basic flow path and the main flow branch. If the connection point is the first port K1, the name of this part is "K1"; if the connection point is the second port K2, the name of this part is "K2"; if the connection point is the bifurcation point a, the name of this part is "a", and so on.

[0156] The third part of the name identifies how each type of basic flow path is merged to connect to the main stream branch. The different merging methods are defined as follows:

[0157] Type A means that each type of basic flow path is independent and connected to the main flow branch in parallel, marked as "A". Figure 11A and Figure 11B As shown, Figure 11C Only one basic flow path is shown as an example, but it can be understood that multiple basic flow paths can be connected in parallel;

[0158] P type means that each type of combined flow path is independent and connected to the main flow branch in parallel, but a peristaltic pump B is required on the main flow branch to better drive fluid metering and liquid inlet. This type of combined flow path is marked as "P", such as Figure 12 As shown;

[0159] Type B means that the first branches 11 of the same or different basic flow paths are combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "B", such as 13A to 13D As shown;

[0160] Type C indicates that the second branches 12 of the same or different basic flow paths are combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "C". 14A to 14C As shown;

[0161] BC type means that the first branch 11 of the same or different basic flow paths are combined and shared, and the second branch 12 is also combined and shared, and then connected to the main flow branch through the first port K1 or the second port K2. This type of combined flow path is marked as "BC", such as 15A to 15D As shown;

[0162] H type means that the bifurcation point a of each type of basic flow path is merged and shared, and is directly connected to the main flow branch through point a. A peristaltic pump or stop valve is connected in series to the main flow branch; or, one or more first branches or second branches in the basic flow path are directly used as the main flow branch; this type of combined flow path is marked as "H", such as Figure 16A or Figure 16B shown.

[0163] It should be noted that the so-called A, B, C, BC, P, H, etc. are named only to distinguish different types of flow path solutions and do not constitute a limitation on the scope of protection of this application. The above flow path solution naming method also applies to the flow path solutions shown in other figures of this application.

[0164] It should be noted that in all types of combined flow paths, the bifurcation point a can be physically a point in the flow path or a section of the flow path. At the same time, in order to more conveniently and concisely display the topological structure of each combined flow path connected to the main flow branch, this application separates the main flow branches in each figure into segments (in three rows) and displays them separately. It should be noted that these main flow branches can also be composed of a connected main flow branch as needed.

[0165] The following describes the structural composition and connection relationships of various combined flow paths. For the sake of brevity, this application schematically illustrates only one or two basic flow paths for certain combined flow paths. It should be noted that multiple basic flow paths can be used in practice. Furthermore, in a combined flow path scheme, there can be one or more main branches. All of these variations are within the scope of protection of this application.

[0166] 3.1A type combined flow path:

[0167] The definition of type A combined flow path is: each basic flow path is independent of each other and is connected to a higher-level main flow branch through its first port K1 or second port K2, thus forming a combined flow path that can be used for parallel liquid inflow (and also for liquid discharge). One port of the main flow branch is closed, and the other port is used as a common outlet for the liquid transported by each basic flow path, such as Figures 11A to 11C shown.

[0168] Figures 11A-11C The following table lists the methods used in Figures 1 to Figure 6 The shown partial combination form is that each basic flow path is connected in parallel to the same main flow branch.

[0169] For example, "1-K1-A type" means that the basic flow path in Figure 1 is connected to the main flow branch through the first port K1, "1-K2-A type" means that the basic flow path in Figure 1 is connected to the main flow branch through the second port K2, and "2-K1-A type" means Figure 2 The basic flow path in is connected to the main flow branch through the first port K1, and so on.

[0170] For example, Figures 11A to 11C As shown, you can Figures 1A to 1E The first port K1 of the basic flow path shown in one of them, Figures 1A to 1E The second port K2 of the basic flow path shown in one of them and Figure 2 The first ports K1 of the basic flow paths shown are independently connected to the same main flow path; Figure 3 The first port K1 (or the second port K2) of the basic flow path shown, Figure 4 The first port K1 of the basic flow path shown and Figure 4 The second port K2 of the basic flow path shown is connected to the same main flow path; or you can also choose Figure 6 The second port K2 of the basic flow path shown and the first port or second port (not shown) of other basic flow paths are connected to the same main flow path. The above basic flow paths can be independently fed with liquid according to the aforementioned metered liquid feeding steps.

[0171] At the same time, in "1-K1-A type", "2-K1-A type", "3-K1-A type", "3-K2-A type", "4-K1-A type" and "6-K2-A type", a liquid detector S is installed on the branch pipe connected to the main branch for metering and positioning, or to detect whether the liquid has reached the detection position, to ensure that the liquid does not enter the main branch according to the working conditions during metering.

[0172] It is understandable that in Figures 11A to 11C The combined flow scheme shown in Figures 1A to 1E as well as Figures 2 to 6 The scope of protection of this application covers all possible combinations of basic flow paths shown in FIG1 . For example, N basic flow paths can be connected to the same trunk flow path, where N is a natural number greater than or equal to 1, and each basic flow path can select its own feasible first port K1 or second port K2 to connect to the same trunk flow path. It can also be understood that the basic flow paths are not limited to the basic flow paths shown in FIG1 to FIG2 . Figure 6 The basic flow path shown can also be selected Figures 7 to 10 Basic flow scheme shown.

[0173] It is understandable that, as mentioned above, although the present application emphasizes the use of thin tubes, this does not mean that other non-thin tube devices that can form various complex combination channels in the present application are excluded. Without affecting the purpose of the invention of the present application, pipes with larger pore diameters can also be partially used, such as Figure 11C As shown, when it is necessary to constant the volume of a conventional volume exceeding, for example, 2 ml, the first branch 11 of the "6-K2-A type" can use a thick constant volume tube to increase the liquid inlet or discharge speed, thereby improving the overall processing or detection speed of the device.

[0174] The beneficial effect of the Type A combined flow path is that the water samples or reagents connected to each basic flow path can be simultaneously and concurrently metered. This performance can greatly improve the overall processing efficiency or detection speed of the device.

[0175] 3.2P type combined flow path

[0176] Preferably, in order to more conveniently realize the flow of liquid, at least one peristaltic pump B can be set on the main flow path of the A-type combined flow path, such as Figure 12 This type of combined flow path is named "P-type combined flow path" in this application.

[0177] Figure 12The two combined flow paths of "5-K2-P type" and "6-K2-P type" are listed. Due to the peristaltic pump B on the main flow path, the fluid in the basic flow path can not only flow by gravity or other pumps, but also use the peristaltic pump B on the main flow path to better control the movement of the liquid. It can be understood that Figure 12 This is for illustrative purposes only. A different number of basic flow paths can also be selected, and each basic flow path can select its own first port K1 or second port K2 to connect to the same main flow path. In this case, the peristaltic pump B in the P-type main flow path needs to work in conjunction with the peristaltic pumps and stop valves in the basic flow paths to better transport the liquid in the flow paths according to the set requirements.

[0178] 3.3B type combined flow path:

[0179] The definition of a Type B combined flow path is: the first branches 11 of the same type of basic flow paths are combined and shared, and then connected to a higher-level main flow branch through the combined shared first port K1 or the independent second port K2 (K2'), thereby forming a combined flow path that can be used for parallel liquid inflow (and also for liquid discharge). One port of the main flow branch is closed, and the other port serves as the common outlet for the transported liquid of each Type B combined flow path, such as 13A to 13D shown.

[0180] 13A to 13D The use of Figures 1A to 1E and Figures 2 to 6 The basic flow paths shown are combined according to the above rules and then connected in parallel to the same main flow branch through the first port K1 or the second port K2.

[0181] For example, "1-K1-B type" means Figure 1A-1E The basic flow path in the first branch 11 is merged and shared, and then connected to the main flow branch through the first port K1; "1-K2-B type" means Figure 1A-1E The basic flow path in the first branch 11 is merged and shared, and then connected to the main flow branch through the second port K2; "4-K1-B type" means Figure 4 The basic flow path in the first branch 11 is merged and shared, and then connected to the main flow branch through the first port K1; "4-K2-B type" means Figure 4 The basic flow path in the first branch 11 is merged and shared, and then connected to the main branch through the second port K2; "6-K2-B type" means Figure 6 The basic flow path in the first branch 11 is merged and shared, and then connected to the main flow branch through the second port K2; and so on.

[0182] Each of the above-mentioned basic flow paths can be fed with liquid according to the aforementioned metered liquid feeding principles and steps. However, when one of the flow pipelines is working, except for the devices on the first branch 11 working together, the devices on the other basic flow paths should be in a static state (peristaltic pump is stationary and the stop valve is closed), which will not be repeated here.

[0183] Preferably, each type B combined flow path can be equipped with a liquid detector S on the branch pipe connected to the main branch for metering and positioning, or detecting whether the liquid reaches the detection position, so as to ensure that the liquid does not enter the main branch during metering according to working conditions.

[0184] It is understandable that in 13A to 13D The combined flow path scheme shown in the figure is only an implementation method formed by combining the basic flow paths shown in the figure according to the type B combined flow path. It can be understood that the present application is not limited to this. The protection scope of the present application covers all permutations and combinations of various basic flow paths. For example, the basic flow paths used to implement the combined flow paths are not limited to Figure 1A-1E and Figures 2 to 6 The basic flow path shown can also be selected Figures 7 to 10 The basic flow path scheme shown is not shown in the figure, and other basic flow path schemes can also be selected.

[0185] Compared with the A-type and P-type combined flow paths, the beneficial effect of the B-type combined flow path is that the number of peristaltic pumps or stop valves is reduced, which correspondingly saves costs and improves stability.

[0186] 3.4C type combined flow path:

[0187] The definition of a C-type combined flow path is: the second branches 12 of the same type of basic flow paths are combined and shared, and then connected to a higher-level main flow branch through each independent first port K1 (K1') or the combined and shared second port K2, thereby forming a combined flow path that can be used for separate liquid inlet (and also for liquid discharge). One port of the main flow branch is closed, and the other port serves as a common outlet for the transported liquid of each C-type combined flow path, such as 14A to 14C shown.

[0188] 14A to 14C The use of Figure 1A-1E and Figures 2 to 6 The basic flow paths shown are combined according to the above rules and then connected in parallel to the same main flow branch through the first port K1 or the second port K2.

[0189] For example, "1-K1-C type" means the basic flow path in Figure 1, where the second branch 12 is combined and shared, and then connected to the main flow branch through the first port K1; "1-K2-C type" means Figure 1AThe basic flow path in the second branch 12 is combined and shared, and then connected to the main flow branch through the second port K2; "4-K2-C type" means Figure 4 The second branch 12 of the basic flow path in the embodiment is merged and shared, and then connected to the main flow branch through the second port K2; and so on.

[0190] Each of the aforementioned basic flow paths can be fed with liquid according to the aforementioned metered liquid feeding principles and steps. However, when one of the flow paths is in operation, the components on the other basic flow paths, except for the components on the first branch 11 working in conjunction with it, should be in a stationary state (peristaltic pump is stationary and stop valve is closed). This will not be repeated here.

[0191] At the same time, each C-type combined flow path can be equipped with a liquid detector S on the branch pipe connected to the main branch for metering and positioning, or detecting whether the liquid has reached the detection position, to ensure that the liquid does not enter the main branch during metering according to the working conditions.

[0192] It is understandable that in 14A to 14C The combined flow scheme shown in Figure 1A-1E and Figures 2 to 6 The basic flow path shown is a part of the most practical flow path formed by combining the C-type combined flow path. The protection scope of this application covers all its permutations and combinations. For example, the basic flow path used to realize the combined flow path is not limited to Figure 1A-1E and Figures 2 to 6 The basic flow path shown can also be selected Figures 7 to 10 The basic flow path scheme shown is not shown in the figure, and other basic flow path schemes can also be selected.

[0193] It should be noted that the “1-K1-C type” combined flow path has two or more access points for connecting to the main branch: K1 and K1'. The above two points can be different locations of the same main branch (such as 14A to 14C As shown), it can also be distributed and connected to different main stream branches (not shown).

[0194] Compared with the A-type and P-type combined flow paths, the C-type combined flow path has the beneficial effect of reducing the number of peristaltic pumps or stop valves, which correspondingly saves costs and improves stability.

[0195] 3.5BC type combined flow path:

[0196] The definition of a BC type combined flow path is: the first branch 11 and the second branch 12 of the same basic flow path are respectively merged and shared, and then connected to a higher-level main flow branch through the merged shared first port K1 or the merged shared second port K2, thereby forming a combined flow path that can be used for liquid inlet (and also for liquid discharge). One port of the main flow branch is closed, and the other port is used as a common outlet for the transported liquid of each BC type combined flow path, such as 15A to 15D shown.

[0197] 15A to 15D The use of Figure 1A-1E and Figures 2 to 6 The basic flow paths shown are combined according to the above rules and then connected in parallel to the same main flow branch through the first port K1 or the second port K2.

[0198] For example, "1-K1-BC type" means Figure 1A-1E One of the basic flow paths has its first branch 11 and second branch 12 merged and shared, and then connected to the main flow branch through the first port K1; "1-K2-BC type" refers to the basic flow path in Figure 1, its first branch 11 and second branch 12 merged and shared, and then connected to the main flow branch through the second port K2; "4-K1-BC type" means Figure 4 The basic flow path in which the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the first port K1; "4-K2-BC type" means Figure 4 The basic flow path in which the first branch 11 and the second branch 12 are merged and shared, and then connected to the main branch through the second port K2; "6-K2-BC type" means Figure 6 In the basic flow path, the first branch 11 and the second branch 12 are respectively merged and shared, and then connected to the main flow branch through the second port K2; and so on.

[0199] in, Figures 15A to 15C The combined flow path in the figure shows a combination of two different types of variants of "1-Basic Type". The devices connected in series on the flow pipeline are a peristaltic pump and a stop valve, and their stop effects are the same.

[0200] Each of the aforementioned basic flow paths can be fed with liquid according to the aforementioned metered liquid feeding principles and steps. However, when one of the flow paths is in operation, the components on the other basic flow paths, except for the components on the first branch 11 working in conjunction with it, should be in a stationary state (peristaltic pump is stationary and stop valve is closed). This will not be repeated here.

[0201] At the same time, each BC type combined flow path can be equipped with a liquid detector S on the branch pipe connected to the main branch for metering and positioning, or detecting whether the liquid has reached the detection position, to ensure that the liquid does not enter the main branch during metering according to the working conditions.

[0202] It is understandable that in 15A to 15D The combined flow scheme shown in Figure 1A-1E and Figures 2 to 6 The basic flow path shown is formed by combining the BC type combined flow paths. The protection scope of this application covers all the permutations and combinations thereof. It can also be understood that, for example, the basic flow paths used to implement the combined flow paths are not limited to Figure 1A-1E and Figures 2 to 6 The basic flow path shown can also be selected Figures 7 to 10 The basic flow path scheme shown is not shown in the figure, and other basic flow path schemes can also be selected.

[0203] Compared with the A-type, P-type, B-type, and C-type combined flow paths, the BC-type combined flow path has the beneficial effect of more effectively reducing the number of peristaltic pumps or stop valves, which correspondingly saves costs and improves stability.

[0204] 3.5H type combined flow path:

[0205] The definition of an H-type combined flow path is: the bifurcation point a of each type of basic flow path is merged and shared, and is directly connected to the main flow branch through point a, and a peristaltic pump or a stop valve is connected in series on the main flow branch; or, one or several first branches or second branches in the basic flow path are directly used as main flow branches. In the H-type combined flow path, a peristaltic pump or a stop valve is connected in series on the flow branches, first branches 11 and second branches 12 of all basic flow paths, and there must be at least one peristaltic pump. Among them, among all the above-mentioned first branches 11 and second branches 12, some of the first branches 11 or second branches 12 are used as constant volume metering conduits, and the other first branches 11 or second branches 12 or the aforementioned main flow branches can be used as outlets for conveying liquids, such as Figure 16A or Figure 16B By using the above combination rules, multiple combined flow paths that can be flexibly combined for liquid inlet (and also for liquid discharge) can be formed.

[0206] Figure 16A Two H-type combined flow paths are shown, both of which use the basic flow path in Figure 1, and the bifurcation point a is combined and used. The difference is that the flow path on the left is connected in series with a peristaltic pump on the main flow branch, and the flow path on the right is connected in series with a stop valve on the main flow branch.

[0207] Figure 16BA more complex H-type combined flow path is shown. Except for the three flow branches at the bottom, each branch at the top can be used as a constant volume metering tube or liquid output outlet.

[0208] Each of the aforementioned basic flow paths can be fed with liquid according to the aforementioned metered liquid feeding principles and steps. However, when one of the flow paths is operating, the components on the other basic flow paths, except for the components on a certain first branch 11 or a certain second branch, should be in a static state (peristaltic pump is stationary and stop valve is closed). This will not be repeated here.

[0209] Compared with A, P, B, C, and BC type combined flow paths, the biggest advantage of the H type combined flow path is its flexible combination. It can use a minimum of devices to measure liquids according to different specifications and then transport them to different ports (such as multiple reaction vessels) for subsequent processing.

[0210] The various combination schemes of the basic flow paths of the present application are described in detail above. During operation, the liquid in each container can be intercepted in predetermined volume segments separately, either simultaneously or selectively from one or several containers. Finally, it is pushed out from the selected ports in sequence or simultaneously. Therefore, the various combination schemes of the above-mentioned basic flow paths can intercept the liquid in multiple different containers separately, simultaneously or in a predetermined order, with high precision and quantitative liquid, and deliver the quantitative liquid intercepted with high precision. Moreover, due to the combination of the basic flow paths, the use of components can be greatly reduced, thereby reducing the overall cost.

[0211] In addition, as mentioned above, Figures 11A to 11C and Figures 12 to 16A and Figure 16B The various types of combined flow path solutions based on the basic flow path are shown as examples. The basic flow path used to realize the combined flow path is not limited to Figures 1A to 1E and Figures 2 to 6 The basic flow path shown can also be selected Figures 7 to 10 The basic flow path scheme shown in the figure can also be selected from basic flow path schemes not shown in the figure. Various possible combinations of these basic flow paths are within the scope of this application.

[0212] In addition, it should be pointed out that the various liquid inlets and / or liquid discharges in the above-mentioned various combined flow paths can be implemented according to the liquid inlet and / or liquid discharge methods of various types of basic flow paths, so these variations are all within the scope of this application.

[0213] 4. Application flow path solution

[0214] In the application flow path solution, a (reaction) vessel 100 is included. The vessel 100 is used for reaction processing and / or detection analysis and has a top opening located at the top and / or a bottom opening located at the bottom.

[0215] In order to inject the required predetermined liquid sample (intercepted with an accurate volume) into the vessel 100 for reaction treatment and / or detection analysis, the above-mentioned basic flow path scheme and / or combined flow path scheme can be connected to the vessel 100. Depending on the application conditions, it can be connected to the vessel 100 at the bottom opening, or it can be connected to the vessel 100 at the bottom opening and the top opening, or it can also be connected to the vessel 100 at the bottom opening and the middle of the vessel 100. In other words, the bottom, top or middle of the vessel 100 can all be used as a connection access point. Preferably, a peristaltic pump or a stop valve is connected to the bottom opening of the vessel 100 to maintain the reaction liquid in the vessel 100 or to discharge the liquid after the reaction is completed.

[0216] like Figure 17 As shown, the device for quantitatively processing liquid (application flow path) has a vessel 100, which is used for reaction treatment and / or detection analysis and has a top opening at the top. Wherein, the top opening is simultaneously connected to various basic flow paths or various combination flow paths (or their suitable combinations). Wherein, each container of various basic flow paths or various combination flow paths can be used to accommodate different liquids, such as distilled water, water samples to be detected, standard liquids, shielding agents, color developers, cleaning solutions, etc. The bottom of the reaction vessel 100 is connected to a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven forward and reverse (can be used to drain liquid downward and blow air upward to stir the liquid).

[0217] like Figure 18 As shown, the device for quantitatively processing liquids (application flow path) comprises a vessel 100, which is used for reaction processing and / or detection analysis and has a top opening at the top and a bottom opening at the bottom. The top opening and the bottom opening are connected to various basic flow paths or various combination flow paths (or suitable combinations thereof). Each container of each basic flow path or various combination flow paths can be used to hold different liquids, such as distilled water, water samples to be tested, standard liquids, shielding agents, color developers, cleaning fluids, etc.

[0218] like Figure 19 and Figure 20As shown, the device for quantitatively processing liquid (application flow path) has a vessel 100, which is used for reaction treatment and / or detection analysis and has a top opening at the top and a bottom opening at the bottom. The bottom opening is connected to various basic flow paths or various combination flow paths (or their appropriate combinations) at the same time. Each container of the various basic flow paths or various combination flow paths can be used to hold different liquids, such as distilled water, water samples to be tested, standard liquids, shielding agents, color developers, cleaning liquids, etc. When the bottom opening is connected to the basic flow path or the combination flow path, the container P can be used not only to hold waste liquid, but also to hold cleaning liquid, and the cleaning liquid is introduced into the vessel 100 to facilitate the cleaning operation of the vessel 100.

[0219] like Figure 20 As shown, preferably, a basic reaction flow path is formed around a reaction vessel 100. The bottoms of multiple basic reaction flow paths can be connected together to share one or more drainage outlets, thereby allowing multiple reaction vessels 100 to work simultaneously, thereby greatly improving work efficiency. Figure 23 As shown, each connecting channel between adjacent reaction vessels must be serially connected with at least one peristaltic pump or shut-off valve for controlling the on-off between the connecting pipelines.

[0220] Under the guidance of the above-mentioned communication mode between the basic flow path or the combined flow path and the reaction vessel 100, a variety of application flow path combination solutions for the device for quantitatively processing liquids can be formed.

[0221] like Figures 21 to 23 These are exemplary embodiments of connecting a basic flow path or a combined flow path solution to the top opening of the reaction vessel 100. In this embodiment, different types of liquids (such as water samples, shielding agents, color developers, etc.) can be introduced relatively independently from above into the vessel 100, thereby avoiding cross contamination of the water sample and reagents.

[0222] Figure 21 The left side of the flow path uses, for example, a "1-K1-BC" type combined flow path to meter distilled water and water samples, which enter from the top of the reaction vessel 100. Simultaneously, the right side uses a "4-K1-B" type combined flow path to allow liquid to enter from the top of the reaction vessel 100. The bottom of the reaction vessel 100 is connected to a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven in both directions (for downward drainage and upward agitation). The advantages of this design are simple principle, concise structure, high metering accuracy, and the simultaneous metering of water sample and reagent preparation solutions, saving time. At the same time, the inflow of water sample and reagent does not interfere with each other, preventing cross contamination.

[0223] Figure 22 The flow path is Figure 21 Based on the flow path, a "4-K1-BC" type combined flow path was used to replace the Figure 24 The bottom of the reaction vessel 100 is connected to a peristaltic pump or shut-off valve. Two flow lines are connected at node b, one for draining waste liquid and the other for metering the cleaning liquid. This design also features a liquid detector Sb connected in series to the bottom line of the reaction vessel 100. This detector, in conjunction with the peristaltic pump below, dilutes the liquid.

[0224] The specific operation process is as follows: first, put the water sample into the reaction vessel 100, then use the peristaltic pump Bb1 to drain the liquid until the last liquid just passes the liquid detector Sb, then stop draining the liquid, and the peristaltic pump Bb1 or peristaltic pump Bb2 reverses to return the intercepted fixed volume of liquid to the reaction vessel 100. After that, the peristaltic pump Bbn starts to feed distilled water. The volume of the liquid fed can be determined by the liquid detector Sb and the feeding time of the peristaltic pump Bbn. Finally, the peristaltic pump Bb1 or peristaltic pump Bb2 reverses to blow all the dilution liquid above the b node into the reaction vessel 100, completing the dilution of the original water sample. Figure 21 compared to, Figure 22 A flow path topology and dilution method for diluting water samples based on the flow path construction concept of this application are described.

[0225] Figure 23 The left side of the flow path uses the "1A-Basic Type" basic flow path to meter the water sample into the top of the reaction vessel 100. At the same time, the right side uses two "4-Basic Type" basic flow paths to enter the top of the reaction vessel 100. The bottom of the reaction vessel 100 is connected to a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven forward and reverse (can be used to drain the liquid downward and blow air upward to stir the liquid). Figure 21 Compared with the flow path, the advantage of this design is the complete separation of the two reagents on the right, eliminating any possibility of cross contamination.

[0226] like Figures 24 to 27 As shown, all of them are ways of connecting the basic flow path or the combined flow path scheme to the bottom opening of the reaction vessel 100. In this embodiment, different types of liquids (such as water samples, shielding agents, color developers, etc.) can be introduced into the vessel 100 relatively independently from the bottom, and waste liquid can be received and cleaned. The beneficial effect of this design is that peristaltic pumps, stop valves, liquid detectors and other devices with the same functions on different combined branches can be used in combination, such as pumps for draining or blowing, distilled water pumps for cleaning, liquid detectors for detecting liquids, etc., which can simplify the flow path and save costs; in addition, the method of introducing and discharging liquids from the bottom of the reaction vessel 100 is also very beneficial for cleaning each pipeline, with high cleaning efficiency, saving cleaning water, and reducing the number of air ports and exhaust ports.

[0227] like Figure 24 The flow path shown is Figure 22The "4-K1-BC" type combined flow path with liquid inlet on the left side of the top of the flow path reaction vessel 100 and the "4-K1-B" type combined flow path with liquid inlet on the right side are moved to the bottom of the reaction vessel 100 for liquid inlet.

[0228] Figure 25 It shows a flow path that can realize the liquid inlet function more simply without reducing the number of water samples and reagents. The flow path is a "4-K1-BC type" combined flow path connected under the reaction vessel, wherein point b to point a is a common first branch, used as the output port for water samples or reagents; the branch of the series peristaltic pump Bd connected to point d is a common second branch, used to drain liquid or pump air into the main flow path, and push the measured liquid into the reaction vessel 100. The multiple branches where the peristaltic pumps Bc, Brn, Br1, and Bb are located are flow pipes. The different metering principles and liquid inlet processes of this combined flow path are Figure 4 The basic flow path and 15A to 15D This has been explained in the introduction of the BC type combined flow path.

[0229] In all application flow paths of this application, the constant volume of liquid during liquid inlet can be achieved by controlling the speed and time of each liquid inlet peristaltic pump, or by controlling the positioning of the liquid segment head at a certain position near the liquid detector S ( Figure 25 ), for example in Figure 25 、 Figure 26 In the example, the liquid detector S between node a and node b can be used to accurately determine the volume of the liquid, or to provide an early warning to determine whether the liquid has passed through this point when the instrument is running.

[0230] exist Figure 26 In order to complete the liquid metering and volume determination more accurately, the series peristaltic pump Bf connected to point f can also be used to empty the liquid from point f to point a and above into the waste liquid barrel through the waste liquid branch. At this time, the right end position of the precise liquid volume determination is located by the position of the physical node f. Figure 26 This connection structure is shown.

[0231] In order to more flexibly utilize the physical space volume between the nodes on the main branch to perform constant volume operation on the liquid to be intercepted, the designer can add some branches connecting air or liquid on the main branch to intercept the volume of different micro-liquid amounts with high precision. Figure 27 An example is shown in which the designer adds a new branch for connecting air or for flushing water discharge at point e between the reagent branch and the distilled water branch to minimize cross contamination between reagents and water samples (standard solution and distilled water).

[0232] In order to completely avoid cross contamination between reagents and water samples (standard solution and distilled water), water samples and reagents can be added simultaneously. Figure 28An example is shown in which the outlets for all reagents are moved to the top of the reaction vessel 100 for inlet.

[0233] Next, we will Figure 27 Take the following as an example to explain the basic principles and processes of flow metering, liquid feeding, stirring, liquid discharge and dilution. Figures 25 to 28 The corresponding principles and processes of other flow paths are similar, so the working processes of similar application flow paths will not be described in detail.

[0234] Figure 27 The high-precision liquid metering process is as follows: To meter a water sample, peristaltic pump Bb first rotates counterclockwise. The sample passes through liquid detector S and stops after a certain volume has been overshot. Peristaltic pump Bb then stops, while peristaltic pump Bf rotates clockwise for a moment, sucking in excess liquid beyond point f and discharging it into waste. This completes high-precision liquid metering of micro-liquid volumes (e.g., 0.05-2 ml). Alternatively, the colorimetric detector G in reaction vessel 100 can be used to meter larger volumes (when the liquid level reaches the optical axis horizontal line at point G, the device detects a signal, thus completing the positional metering). Peristaltic pumps Bb and Bf then stop, while peristaltic pumps Bg or Be rotate counterclockwise to deliver the liquid between points b and f into reaction vessel 100. This method can be used to meter and meter other liquids and reagents within the flow path. By selecting different cutoff points for the water segment head (abbreviated as "water head") and the air purge point, designers can achieve different micro-liquid metering volumes. By doing so, a predetermined volume of different liquids in different containers can be pushed into the vessel 100 in a predetermined order, and then a reaction and / or analysis can be performed in the vessel 100 .

[0235] The peristaltic pumps Bg, Be, or Bf rotate counterclockwise to blow air into the reaction vessel 100 to stir the liquid. The three pumps can also serve as outlets for liquid discharge.

[0236] Figure 27 The flow path is used to dilute the liquid in the reaction vessel 100 as follows: first, the peristaltic pump Bg or Be is started to discharge the liquid. When the water tail does not pass point f, the peristaltic pump is stopped. Then, the peristaltic pump Bf is rotated clockwise to discharge the excess liquid to be diluted beyond point f. Then, the peristaltic pump Bg or Be is rotated counterclockwise to deliver the intercepted liquid into the reaction vessel 100. Finally, the aforementioned metered liquid injection mode is used to inject distilled water into the reaction vessel 100 using a micro-liquid volume or large-volume liquid injection mode, and the mixture is evenly mixed after blowing and stirring.

[0237] exist Figures 22 to 28In the combined flow path at the bottom or top of the reaction vessel 100, at least one peristaltic pump is vented to the atmosphere. Preferably, the peristaltic pump vented to the atmosphere is located farthest from the vessel 100 on the common capillary tube. Therefore, the peristaltic pump can accurately deliver all reagent containers or reagent vessels on the common capillary tube into the reaction vessel 100.

[0238] Preferably, if Figures 22 to 28 As shown, a liquid detector S is positioned adjacent to the bottom opening of the common capillary tube. This allows for the interception of a specific volume of liquid between each bifurcation point and the liquid detector S, thereby obtaining a more accurate volumetric measurement of the liquid sample. The liquid detector can be positioned anywhere between the intersection point b and the bottom a of the reaction vessel 100. The advantages of the liquid detector S are described in detail above.

[0239] Furthermore, in all application flow paths, the order in which the containers P are arranged relative to the vessel 100 can be selectively designed based on the operating procedure. For example, because air is required to propel various reaction liquids, the peristaltic pump directly connected to the atmosphere needs to be located farthest from the vessel 100 compared to the peristaltic pumps connected in series in the passage lines of other containers.

[0240] From the above description, it is clear that Figures 25 to 28 In the embodiment shown, the combination of basic flow paths has achieved a high degree of dynamic integration. Figure 26 As shown, the reaction flow path also includes a waste liquid container Pf, which is a container connected to the atmosphere and has a waste liquid pipeline extending from the inside of the waste liquid container Pf to the outside of the waste liquid container Pf, and a peristaltic pump Bf is arranged in series in the waste liquid pipeline. Preferably, the peristaltic pump in the waste liquid pipeline is connected to the portion between the point b and the bottom opening a (at Figure 26 At this time, the liquid detector (S) is located near the intersection f. Figure 26 As shown, the leftmost peristaltic pump is directly connected to the atmosphere, allowing air to be introduced into the common capillary tube. Meanwhile, the waste liquid container Pf and its peristaltic pump Bf are dedicated to receiving waste liquid, thus avoiding interference with the introduction of air. Furthermore, since the waste liquid container Pf is relatively close to the vessel 100, it can achieve local discharge, improving efficiency and preventing contamination of the waste liquid. The features of the waste liquid container Pf can also be applied to other suitable flow paths.

[0241] exist Figure 27In the illustrated embodiment, an air / rinse water outlet container is also added to perform a dilution function. In the flow path of the present application, the methods for implementing the dilution function are flexible. In addition to the aforementioned dilution scheme, different operations can also be used to achieve the dilution function. Specifically, for the liquid to be diluted in the vessel 100, first, while the other peristaltic pumps are stationary, the peristaltic pump of the air / rinse water outlet container is rotated to draw the liquid to be diluted into the air / rinse water outlet container. At this point, the liquid to be diluted fills the area between the air / rinse water outlet and the bottom opening a. Then, the other peristaltic pumps are turned off, and only the peristaltic pump of the waste liquid container is rotated, causing the liquid to be diluted between the intersection f and the bottom opening a to be discharged into the waste liquid. At this point, the liquid to be diluted fills the area between the air / rinse water outlet and f. Then, the other peristaltic pumps are turned off, and only the leftmost peristaltic pump is operated, using air to push the liquid to be diluted between the intersection e and f into the vessel 100. Distilled water is then drawn into the vessel 100, completing the dilution process of the liquid to be diluted.

[0242] Figure 29 Shown in Figures 26 to 28 Based on this, a "4-K2-BC" combined flow path replaces the separate inlet branches for the raw water sample, standard solution, and distilled water. Because the first branch, c1-Kc, is shared, the inlet volumes for the sample, standard solution, and distilled water are consistent, minimizing cross-contamination with reagents. If larger volumes of liquid need to be metered, the volumetric conduit c1-Kc can be replaced with a branch with a thicker tube in series. The thicker tube must open upwards and have its outlet higher than the bifurcation point c1 to prevent liquid from escaping through the outlet.

[0243] Figure 30 It will Figure 29 The combined inlet flow path for the water sample, standard solution, and distilled water has been moved to the rear end of the main flow path (the far left end relative to the reaction vessel 100). This configuration allows the Kc port to be used directly as an air port and a drain for rinse water. Placing the water sample, standard solution, and distilled water at the far left end helps protect these three liquids from contaminating the reagents or reaction solution on the right. This position adjustment of a similar basic flow path or combined flow path on the main flow path can take many forms, not limited to the specific form shown in the figure, and all such variations are within the scope of this application.

[0244] Figure 31 and Figure 32 They are Figure 29 and Figure 30 The main branch "4-K2-BC type" combined flow path is replaced with another flow path, the new main branch flow path type is "1-K1-P type". Its liquid inlet method and process can be found in the previous description of this application.

[0245] Figures 25 to 32The characteristic of the application flow path is that the first branches 11 and / or the second branches 12 corresponding to the inlet and outlet ports are merged and shared, so that the devices (peristaltic pumps, stop valves or liquid detectors) used in the application flow path are minimized, thereby simplifying the flow path and reducing costs.

[0246] exist Figures 25 to 32 In the application flow path, since the constant volume branch is shared, all reagents can only be constant volume in the common constant volume branch in turn, and then sent to the reaction vessel 100. In order to speed up the metering and liquid injection speed, the application also proposes several application flow paths that can perform concurrent metering and achieve rapid analysis.

[0247] Figure 33 is Figure 29 Based on the above, the flow lines from reagent 1 to reagent n are replaced with a "4-basic" flow line (N of the above reagent inlet flow lines form a "4-K2-BC" combined flow line). The biggest advantage of this type of flow line is that it can achieve concurrent metering and volume determination of water samples and various reagents, and then quickly add liquids in sequence according to process needs. Similarly, it can also achieve simultaneous cleaning of each branch, which can greatly save the full cycle detection time of the instrument.

[0248] It should be noted that the outlet of the first branch 11 of each of the aforementioned "4-Basic" reagent flow paths still returns to the reagent bottle container P. This has the advantage that the reagent pumped out by the peristaltic pump returns to the reagent bottle, saving reagent and eliminating the impact of bubbles that may have originally been contained in the capillary tube. By increasing the rotation time of the peristaltic pump, the stability and high precision of the entire liquid inlet system are ensured. This structural feature and its beneficial effects are applicable to all flow paths submitted in this application.

[0249] Figure 34 Another practical application flow path is shown, in which the water sample, standard solution, and distilled water are metered and fixed in parallel on their respective first branches through a "4-basic" flow path. They are then connected to a higher-level "4-basic" flow path, ultimately connecting to the bottom of the reaction vessel 100. The individual reagents are connected to the top opening of the reaction vessel 100 in the same manner. The advantage of this flow path is that each liquid is metered in individually, resulting in a fast flow rate. This flow path is particularly advantageous during dilution, as distilled water is already readily available. To further reduce the number of components, the peristaltic pumps for the "air / rinse water outlets" on the upper and lower main branches of this application flow path can be omitted, with air or rinse water discharged directly from ports such as Kb / Kc / Kd.

[0250] Figure 35 An application flow path is shown, which uses a stop valve group (F3, F4, ..., Fn in the dotted box) and a peristaltic pump Bc2, which functionally replaces Figure 33The multiple branch lines connected to the peristaltic pumps at the lower end of point C1 can also be replaced by an N-to-1 multi-channel switching valve.

[0251] Figure 36 Shows a Figure 33 This system expands the application flow path for multiple detection indicators. In this flow path, reagents for four different detection indicators (COD, ammonia nitrogen, total phosphorus, and total nitrogen) are connected to the main flow path below the reaction vessel via different nodes h, g, t, and r. The reaction vessel 100 is shared by the four indicators. The inlet channels for the water sample, standard solution, and distilled water are connected to the main flow path below the reaction vessel from point C. The drainage and air pumping are driven by peristaltic pumps Bf and Bq, which are also shared. This application flow path can be easily expanded to realize the function of sequentially detecting four indicators in a time-sharing manner, at a low cost, by simply adding a few more peristaltic pumps and their control components.

[0252] Figure 37 The flow path will Figure 36 The distilled water branch in the flow path is separated into an independent "4-basic type" flow path structure, which can be used to complete the metering and volume determination of the diluent distilled water in advance during the dilution operation, thereby reducing the time required for liquid preparation during the dilution operation.

[0253] Figure 38 and Figure 39 is another practical application flow path type. Figure 38 In the example, the main body connected to the bottom of the reaction vessel is a "5-K2-P" (or "6-K2-P") combined flow path. Each intersection b, c, d, e, r, and rn is connected to a "5-basic" flow path (or "6-basic" flow path). There is an "air / rinsing water / waste liquid outlet" on the left and right sides of the flow path, respectively, to achieve rapid liquid inlet and outlet and complete dilution. It should be noted that the peristaltic pump B at the bottom of the reaction vessel 100 can also be located on the top connection pipeline.

[0254] Figure 39 It is applied Figure 37 The combination of ideas will Figure 37 All "4-basic type" flow paths and "4-K2-C" type combination flow paths are replaced by "5-basic type" (or "6-basic type") flow paths and "5-K2-P type" (or "6-K2-P type") combination flow paths respectively.

[0255] In order to use as few devices as possible to measure more indicators (requires more reagents) or achieve more functions, for example, the analyzers for total phosphorus and total nitrogen have the same reagent, and the customer hopes to have an instrument with two-in-one functions that can measure total phosphorus and total nitrogen at the same time. Figures 40 to 42 Several flow paths are provided to solve the above problems.

[0256] Figure 40 is Figure 36 Based on the original reaction vessel 100, a second reaction vessel was added in parallel via intersection c. The bottom pipelines of the two reaction vessels are each connected in series with a shutoff valve Fc / Fw. By controlling the opening and closing of shutoff valves Fc and Fw, the indicator reagents connected below the main flow path can be directed to enter the two different reaction vessels, thereby achieving simultaneous detection of two indicators.

[0257] Figure 41 is Figure 39 Based on the above, a second reaction vessel is added in parallel next to the original reaction vessel 100 through the intersection c. A peristaltic pump Bc / Bw is connected in series to the bottom pipelines of each of the two reaction vessels. By controlling the start and stop of the peristaltic pump Bc / Bw, the indicator reagents connected below the main flow path can be controlled to enter the two different reaction vessels respectively, thereby achieving simultaneous detection of two indicators. The above peristaltic pump can also be connected in series to the sealed pipeline at the top of the reaction vessel.

[0258] Figure 42 This figure shows a practical application flow path based on an H-type combined flow path. This flow path can simultaneously detect total phosphorus and total nitrogen using a small number of peristaltic pumps, stop valves, liquid detectors, and two reaction vessels. Furthermore, the reagent port and water sample, standard solution, and distilled water ports used for both indicators can be shared.

[0259] Taking the measurement of a water sample as an example, the specific liquid filling and draining process is as follows: Before operation, all shutoff valves and peristaltic pumps on the branch lines are closed or stationary. First, shutoff valve Fe is opened, and peristaltic pump Be1 rotates counterclockwise, allowing the water sample to overflow into the capillary tube at the e-Ke end and to reach a constant volume. Then, peristaltic pump Be1 is turned off, and peristaltic pump Bk rotates counterclockwise, pumping the water sample from the capillary tube at the e-Ke end into the left reaction vessel. The same method is then used to transfer the water sample to the right reaction vessel. Then, using the same method, various reagents are sequentially filled into the capillary tube r-Kr1 or the capillary tube rn-Krn to a constant volume and pumped into different reaction vessels on the left and right to begin the reaction test. After the test is completed, the liquid is drained by rotating Bx, Bf, Bk, and B1 clockwise (usually, the flow rates of Bx and Bf are greater than those of Bk and B1).

[0260] like Figures 21 to 42 The following are schematic diagrams of the reaction flow paths of the preferred embodiments of the present application, and their working process can be selected and applied in combination with the basic flow path and the combined flow path scheme. As shown in the accompanying drawings, the arrows in the figures can be used to make corresponding explanations or to indicate the replacement of adjacent diagrams. A zigzag line can represent a longer pipeline. In addition, some ports can flow back into the container P to save liquid in the event of overflow while avoiding contamination of the external environment.

[0261] In addition, it needs to be explained that when describing the working processes of the above-mentioned basic flow paths, combined flow paths and application flow paths, the liquid inlet process and liquid discharge process of various basic flow paths are described in detail, and the liquid inlet process and liquid discharge process of certain embodiments of various combined flow paths and application flow paths are described in detail by way of example. However, it can be understood by those skilled in the art that, on the basis of the liquid inlet and liquid discharge processes of the basic flow paths, in the combined flow paths and application flow paths and their various modified combination embodiments, the possible existing implementation methods of various simultaneous and / or sequential implementations of the liquid inlet and liquid discharge methods of various basic flow paths are all within the scope of this application, and are not limited to these implementation methods explicitly disclosed in this application and the drawings in its specification.

[0262] For the sake of brevity, this application does not provide a detailed description of each combination flow path and application flow path and its liquid inlet and discharge processes, but rather describes them by way of examples. Therefore, for those skilled in the art, based on the content already disclosed in this application, they can know the technical contents of other combination flow paths and application flow paths that are not described in detail. Therefore, the technical contents of these combination flow paths and application flow paths are also deemed to be fully disclosed in this application.

[0263] In addition, to fully demonstrate the structure and operating principles of the technical solution, this application is mainly described according to a three-layer architecture: basic flow path, combined flow path, and application flow path. Each solution in each layer of the architecture has its own characteristics for actual industrial application. Therefore, the applicant has designed a patent layout for each technical solution at each level disclosed in this application, and has gradually filed subsequent applications based on this patent layout to provide sufficient patent protection for the innovative achievements of this application.

[0264] The preferred embodiments of the present application are described in detail above with reference to the accompanying drawings. However, the present application is not limited to the specific details of the above embodiments. Within the technical concept of the present application, various simple variations can be made to the technical solution of the present application, and these simple variations all fall within the scope of protection of the present application (for example, Figure 43 Flow path shown). It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, this application will not further describe various possible combinations. In addition, the various different embodiments of this application can also be combined in any manner, as long as they do not violate the concept of this application, and they should also be regarded as the content disclosed in this application.

Claims

1. A device for quantitatively treating a liquid, characterized in that The device includes: a container (P) for containing the liquid to be extracted, the container (P) being a closed container not open to the atmosphere, the closed container being connected to a pressurizing device for increasing the air pressure in the container, the flow conduit (10) extending from the interior of the container (P) to the outside of the container (P); and A capillary tube comprising: A through-flow conduit (10), the through-flow conduit (10) extending outward from the interior of the container (P) to a bifurcation point (a); a first branch (11), the first branch (11) being in communication with the through-flow conduit (10) and extending from the bifurcation point (a) to the first port (K1); and a second branch (12), the second branch (12) being in communication with the through-flow pipeline (10) and extending from the bifurcation point (a) to a second port (K2); A peristaltic pump (B3) is arranged in series in at least one of the through-flow pipeline (10), the first branch (11) and the second branch (12); a shut-off valve (F1, F2) or another peristaltic pump (B2, B3) is arranged in series in at least another of the through-flow pipeline (10), the first branch (11) and the second branch (12), so as to be able to intercept a predetermined volume of liquid between the bifurcation point (a) and the first port (K1) or the second port (K2); wherein the aperture of the capillary tube is 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.5 mm to 2 mm.

2. The device according to claim 1, characterized in that A first stop valve (F1) is provided in series in the flow pipeline (10), and a third peristaltic pump (B3) is provided in series in the second branch (12). The third peristaltic pump (B3) cooperates with the first stop valve (F1) and the pressurizing device to allow a predetermined volume of liquid between the bifurcation point (a) and the first port (K1) to flow out of the first port (K1) or the second port (K2).

3. The device according to claim 2, characterized in that A second stop valve (F2) is provided in series in the first branch (11), and the third peristaltic pump (B3) also serves as the pressurizing device (13).

4. The device according to claim 2, characterized in that The pressurizing device is a heater (30) disposed in the container, and the heater is used to heat the air in the container; or The pressurizing device comprises an auxiliary container (P2) connected to the atmosphere, the auxiliary container (P2) being connected to the container (P) via a fourth peristaltic pump (B4) so as to pressurize the liquid in the auxiliary container (P2) into the container (P); or The pressurizing device includes a fourth peristaltic pump (B4), and the liquid container (P) is connected to the external atmosphere through the fourth peristaltic pump (B4).

5. The device according to claim 2, characterized in that The first branch (11) is provided with a liquid detector (S) at a position adjacent to the first port (K1), and the predetermined volume of liquid between the bifurcation point (a) and the first port (K1) is the liquid between the bifurcation point (a) and the liquid detector (S); and / or The first port (K1) is provided with an extension section extending downward, preferably vertically downward.

6. The device according to claim 5, characterized in that The liquid between the bifurcation point (a) and the liquid detector (S) is the liquid from the bifurcation point (a) to a predetermined offset point based on the liquid detector (S).

7. A method for quantitatively treating a liquid, characterized in that The method is based on the device according to any one of claims 1 to 6 for quantitatively processing liquid, and the method comprises: Pressurizing the container (P) so that the liquid in the container (P) reaches the first port (K1) when the second branch (12) is blocked; and Air is allowed to enter from the first port (K1) or the second port (K2) to intercept a predetermined volume of liquid between the bifurcation point (a) and the first port (K1) or the second port (K2).

8. The method according to claim 7, characterized in that A first stop valve (F1) is provided in series in the flow pipeline (10), and a third peristaltic pump (B3) is provided in series in the second branch (12), so that air enters from the first port (K1) or the second port (K2) to intercept a predetermined volume of liquid between the bifurcation point (a) and the first port (K1) or the second port (K2), comprising: The first stop valve (F1) is closed, and under the drive of the third peristaltic pump (B3), air is allowed to enter from the first port (K1) or the second port (K2), so that the liquid between the bifurcation point (a) and the first port (K1) is pushed out from the first port (K1) or the second port (K2).

9. The method according to claim 8, characterized in that A second shut-off valve (F2) is provided in series in the first branch (11) to pressurize the container (P) so that the liquid in the container (P) reaches the first port (K1) when the second branch (12) is shut off, comprising: Open the first stop valve (F1), close the second stop valve (F2), and drive the third peristaltic pump (B3) to rotate clockwise, so that air enters the container (P) from the second port (K2) through the first stop valve (F1) to increase the pressure; First, the first stop valve (F1) is closed, the third peristaltic pump (B3) is kept stationary, and then the first stop valve (F1) and the second stop valve (F2) are opened. Under the action of the internal pressure, the liquid in the container (P) enters the flow line (10), and then passes through the first stop valve (F1) and the second stop valve (F2) to reach the first port (K1).

10. The method according to claim 8, characterized in that A heater (30) is provided in the container (P), no components are provided in series in the first branch (11), and the container (P) is pressurized so that the liquid in the container (P) reaches the first port (K1) when the second branch (12) is cut off, comprising: The first stop valve (F1) is opened, the third peristaltic pump (B3) is stationary, and the heater (30) heats and pressurizes the air in the container (P). Under the action of the internal pressure, the liquid in the container (P) enters the flow pipe (10), and then passes through the first stop valve (F1) and the bifurcation point (A) to reach the first port (K1).

11. The method according to claim 8, characterized in that The container (P) is connected to another auxiliary container (P2) that is open to the atmosphere through a fourth peristaltic pump (B4). The fourth peristaltic pump (B4) pressurizes the liquid in the auxiliary container (P2) into the container (P) to pressurize the container (P).

12. The method according to claim 8, characterized in that The liquid container (P) is directly connected to the external atmosphere through a fourth peristaltic pump (B4), and the fourth peristaltic pump (B4) allows the external atmosphere to enter the container (P) to pressurize the container (P).

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