Blood separation device

Abstract

The invention provides a blood separation device, and relates to the technical field of blood detection clinical instruments. Comprising a base, a separation disc and a power mechanism, the separation disc is detachably connected with the power mechanism, and the power mechanism is arranged on the base; a placement groove is formed in the separation disc, and a test tube fixing piece is arranged in the placement groove; the test tube fixing piece comprises a clamping piece and a temperature control bag, and the temperature control bag is annular; the temperature control bag is provided with a filling opening, and the filling opening is filled with cooling liquid. The device further comprises a cooling liquid pressurizing and filling device. Compared with the prior art, the structure is simple, the use is convenient, the sample temperature in the separation process can be effectively controlled and stabilized, and the blood separation effect is effectively ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of clinical blood testing instruments, and in particular to a blood separation device. Background Art

[0002] Blood is composed of plasma, platelets, and blood cells. Centrifugation allows the separation of its components based on their weight. Blood separation technology is a crucial component of blood testing, enabling targeted detection of specific components. It also serves as a symptomatic treatment, rapidly removing pathological blood cell components and improving complications associated with hyperstasis syndrome and hyperviscosity.

[0003] During blood separation, the centrifugation temperature for preparing platelets and granulocytes is 20°-24°, while the centrifugation temperature for preparing other blood components is 2°-6°. This temperature difference is quite large, and some special diseases, such as multiple myeloma, are prone to poor serum separation. Higher temperatures can effectively increase the amount of serum separation. Existing blood separation devices are unable to adjust and control the sample temperature during separation. At the same time, the centrifugal process generates centrifugal force and friction during the centrifugation process, causing the sample temperature to rise, thereby affecting the separation effect. However, existing blood separation devices have a simple structure and a single function. In response to the temperature impact of the centrifugation operation on the sample, the existing devices are unable to effectively stabilize the sample temperature during separation, nor can they adjust the sample temperature during separation according to the specific conditions of the blood sample. This often greatly reduces the separation effect, affecting the test results after separation, and easily leads to a reduction in the effectiveness of blood separation treatment due to poor separation effect, greatly increasing the patient's treatment costs and endangering the patient's health.

[0004] Therefore, there is an urgent need for a blood separation device that can effectively control the sample temperature to solve the above problems. Summary of the Invention

[0005] The object of the present invention is to provide a blood separation device which has a simple structure, is easy to use, can effectively control and stabilize the sample temperature during the separation process, and effectively ensures the blood separation effect.

[0006] The embodiment of the present invention is achieved as follows:

[0007] An embodiment of the present application provides a blood separation device, which includes a base, a separation disc and a power mechanism. The separation disc is detachably connected to the power mechanism, and the power mechanism is arranged on the base; a placement groove is provided on the separation disc, and a test tube fixing member is provided in the placement groove; the test tube fixing member includes a clamping member and a temperature control bag, and the temperature control bag is annular; the temperature control bag is provided with a filling port, and the interior of the temperature control bag is filled with coolant; and a coolant pressurized filling device is also included.

[0008] In some embodiments of the present invention, a vertical cavity is provided in the above-mentioned test tube fixture, and an opening communicating with the vertical cavity is provided at the upper end of the test tube fixture; a clamping member is provided at the opening, and a temperature control bag is provided in the vertical cavity and connected to the bottom of the clamping member; a vertical through hole is provided on the clamping member, and the filling port passes through the vertical through hole and is fixedly connected thereto.

[0009] In some embodiments of the present invention, the above-mentioned clamping member includes a fixed clamping member and a movable clamping member, and the fixed clamping member and the movable clamping member are arranged in an arc shape relative to each other; the fixed clamping member is fixedly arranged on one side of the opening, and a horizontal slide groove is arranged at the opening, and the movable clamping member is slidably connected to the horizontal slide groove; a telescopic rod is arranged on the side of the movable clamping member away from the fixed clamping member.

[0010] In some embodiments of the present invention, the fixed clamp is arranged on a side away from the center of the separation disc, and the movable clamp is arranged on a side close to the center of the separation disc.

[0011] In some embodiments of the present invention, the bottom of the vertical cavity is in an inverted cone shape and is provided with an elastic buffer pad.

[0012] In some embodiments of the present invention, the inclination of the tapered bottom of the vertical cavity on the side close to the fixed clamp is greater than that on the side close to the movable clamp.

[0013] In some embodiments of the present invention, the placement groove is arranged in a long strip shape along the radial direction of the separation disk, and the outer side of the test tube fixing piece is arranged in a square shape; a plurality of grooves are evenly arranged on both sides of the radial direction of the placement groove, and clamps adapted to the shape of the grooves are arranged on both sides of the test tube fixing piece.

[0014] In some embodiments of the present invention, the cross section of the groove is square, a horizontal concave hole is provided on the side of the clamp away from the test tube fixture, and a top block connected to its bottom through a telescopic spring is provided in the horizontal concave hole.

[0015] In some embodiments of the present invention, the above-mentioned coolant pressurized filling device includes a storage tank, which is equipped with a temperature regulation system; an infusion tube and an electric pump are provided in the storage tank, and one end of the infusion tube is detachably connected to the filling port.

[0016] In some embodiments of the present invention, a pressure sensor and a temperature sensor are provided in the temperature control bag.

[0017] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0018] Existing blood separation devices are unable to effectively stabilize the sample temperature during separation, nor can they adjust the sample temperature during separation according to the specific conditions of the blood sample. The present invention provides a blood separation device, which includes a base, a separation disc, and a power mechanism, wherein the separation disc and the power mechanism are detachably connected and the power mechanism is disposed on the base; the separation disc is provided with a placement groove, and the placement groove is provided with a test tube fixture; the test tube fixture includes a clamping member and a temperature control bag, and the temperature control bag is annular; the temperature control bag is provided with a filling port, and the interior of the temperature control bag is filled with coolant; and a coolant pressurizing filling device is also included.

[0019] The present invention provides a placement groove on the separation disk, and the sample is fixed by the clamping part on the test tube fixing part and then placed in the placement groove for positioning; the annular temperature control bag can effectively fit the sample after being pressurized and filled with coolant, and the sample temperature is controlled and stabilized by heat transfer; at the same time, the staff can use the coolant pressurized filling device to fill the coolant with a predetermined temperature into it through the filling port of the temperature control bag; the detachable separation disk and power mechanism make the replacement and maintenance of the device more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 A front view of an embodiment of the present invention;

[0022] Figure 2 A top view of a separation disc according to an embodiment of the present invention;

[0023] Figure 3 is a cross-sectional view of a test tube fixing member according to an embodiment of the present invention;

[0024] Figure 4 is a cross-sectional view of a clamping member according to an embodiment of the present invention;

[0025] Figure 5 for Figure 2 A magnified view of point A;

[0026] Figure 6 for Figure 4 Magnified view of point B;

[0027] Figure 7 A front view of an embodiment of the present invention;

[0028] Figure 8This is a cross-sectional view of a separated upper cover according to an embodiment of the present invention.

[0029] Icons: 1. Base; 2. Separation plate; 3. Power mechanism; 4. Placement slot; 5. Test tube fixture; 6. Temperature control bag; 7. Filling port; 8. Vertical cavity; 9. Opening; 10. Vertical through hole; 11. Fixing clamp; 12. Movable clamp; 13. Horizontal slide; 14. Telescopic rod; 15. Buffer pad; 16. Groove; 17. Clamp; 18. Horizontal recessed hole; 19. Telescopic spring; 20. Top block; 21. Storage tank; 22. Temperature regulation system; 23. Infusion tube; 24. Electric pump; 25. Separation cover; 26. Annular slide; 27. Rotating cover; 28. Regular hexagonal groove; 29. Infusion through hole; 30. Liquid separation chamber; 31. Bearing; 32. Sliding slide; 33. Connecting pipe; 34. Liquid separation tube; 35. Positioning pin; 36. Support column. DETAILED DESCRIPTION

[0030] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.

[0031] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort shall fall within the scope of protection of the present invention.

[0032] Example

[0033] Please refer to Figure 1-6 This embodiment provides a blood separation device, which includes a base 1, a separation disc 2 and a power mechanism 3. The separation disc 2 is detachably connected to the power mechanism 3, and the power mechanism 3 is arranged on the base 1; a placement groove 4 is provided on the separation disc 2, and a test tube fixing member 5 is provided in the placement groove 4; the test tube fixing member 5 includes a clamping member and a temperature control bag 6, and the temperature control bag 6 is annular; the temperature control bag 6 is provided with a filling port 7, and the interior of the temperature control bag is filled with coolant; and a coolant pressurized filling device is also included.

[0034] During blood separation, the centrifugal temperatures used to prepare various blood components vary widely, and the centrifugal process generates centrifugal force and friction during the centrifugal process, causing the sample temperature to rise, thereby affecting the separation effect. The present invention provides a placement slot 4 on the separation disc 2, allowing the sample to be positioned after being secured by a clamp on a test tube fixture 5 and then placed in the placement slot 4. The annular temperature control bag 6, after being pressurized and filled with coolant, can effectively adhere to the sample, controlling and stabilizing the sample temperature through heat transfer, effectively ensuring the suitability and stability of the sample separation temperature during separation. Furthermore, the operator can use a coolant pressurized filling device to fill the temperature control bag 6 with pre-set coolant through the filling port 7. The detachable connection between the separation disc 2 and the power mechanism 3 facilitates replacement and maintenance of the device. It is understood that the annular temperature control bag 6 can also adhere to the sample after being filled with liquid. The coolant can be a liquid with a large specific heat capacity, preferably water. The temperature control bag 6 can be made of rubber with good thermal conductivity, such as a silicone water bag. The filling port 7 can be equipped with a switch.

[0035] In some embodiments of the present invention, a vertical cavity 8 is provided within the test tube holder 5, and an opening 9 is provided at the upper end thereof, communicating with the vertical cavity 8. A clamp is positioned at the opening 9, and a temperature control bag 6 is positioned within the vertical cavity 8 and connected to the bottom of the clamp. The clamp is provided with a vertical through-hole 10, through which the filling port 7 passes and is fixedly connected. The maximum volume of the temperature control bag 6 is greater than that of the vertical cavity 8. The arrangement of the vertical cavity 8 allows the temperature control bag 6 to be positioned within the vertical cavity 8. After being filled with liquid, the temperature control bag 6 can fully fill the internal space, achieving close contact and heat exchange with the sample while also assisting in securing the sample. During centrifugation, the sample tilts outward under the influence of centrifugation, which can easily cause displacement and reduce the separation effect. However, under the centrifugal force, the coolant within the temperature control bag 6 can partially move to the side of the sample away from the center of the separation disk 2, providing effective support for the sample and preventing loosening and displacement that may affect the separation effect. The vertical through hole 10 is provided to facilitate the staff to fill or extract liquid from the temperature control bag 6 .

[0036] In some embodiments of the present invention, the clamping member includes a fixed clamping member 11 and a movable clamping member 12, and the fixed clamping member 11 and the movable clamping member 12 are arranged in an arc shape relative to each other; the fixed clamping member 11 is fixedly arranged on one side of the opening 9, and a horizontal slide 13 is provided at the opening 9, and the movable clamping member 12 is slidably connected to the horizontal slide 13; a telescopic rod 14 is provided on the side of the movable clamping member 12 away from the fixed clamping member 11. The staff can control the extension and retraction of the telescopic rod 14 to achieve the movement of the movable clamping member 12 on the horizontal slide 13, thereby achieving the approach and separation of the movable clamping member 12 and the fixed clamping member 11, thereby tightening or loosening the sample. It is understandable that the telescopic rod 14 can be selected from the common electric telescopic rod 14 or manual telescopic rod 14 on the market; a clamping member can also be provided near the bottom of the vertical cavity 8 to further stabilize the sample, and the temperature control bag 6 is located between the upper and lower clamping members.

[0037] In some embodiments of the present invention, the fixed clamp 11 is arranged on a side away from the center of the separation disk 2, and the movable clamp 12 is arranged on a side close to the center of the separation disk 2. The bottom of the vertical cavity 8 is in an inverted cone shape and is provided with an elastic buffer pad 15. The provision of the buffer pad 15 can make the sample close to the bottom while avoiding damage due to collision or pressure. The side of the cone-shaped bottom of the vertical cavity 8 close to the fixed clamp 11 has a greater inclination than the side close to the movable clamp 12, which is convenient for staff to place samples of different diameters. The bottom of the side with a larger inclination can provide good support for the sample, while the side with a smaller inclination allows the bottom of the sample to better move toward and fit closely to the side with a larger inclination. Furthermore, a gasket can be added to the fixed clamp 11 to make it fit closely to the side of the sample in the vertical state after placement.

[0038] In some embodiments of the present invention, the placement slot 4 is arranged in an elongated strip along the radial direction of the separation disc 2, and the outer side of the test tube fixture 5 is arranged in a square shape; a plurality of grooves 16 are evenly arranged on both radial sides of the placement slot 4, and clamps 17 that match the shape of the grooves 16 are provided on both sides of the test tube fixture 5. The elongated placement slot 4 allows staff to freely select the centrifugal position of the sample according to actual conditions, and adjust it by pulling out and inserting the test tube fixture 5; the arrangement of the clamps 17 and grooves 16 effectively limits the test tube fixture 5 and facilitates position adjustment. It is understandable that a device housing or a centrifugal cover can be provided to limit the upper part of the test tube fixture 5 to prevent it from moving out.

[0039] In some embodiments of the present invention, the cross-section of groove 16 is square. A horizontal recess 18 is provided on the side of latch 17 away from test tube holder 5. A top block 20 is disposed within horizontal recess 18 and connected to its bottom via a telescopic spring 19. The arrangement of top block 20 and the spring effectively increases the stability of test tube holder 5 through friction between top block 20 and groove 16. Furthermore, a retaining recess can be provided in groove 16 to further increase friction between it and top block 20.

[0040] In some embodiments of the present invention, the coolant pressurized filling device includes a storage tank 21, which is equipped with a temperature control system 22. An infusion tube 23 and an electric pump 24 are provided within the storage tank 21, one end of which is detachably connected to the filling port 7. The electric pump 24 ensures that the infusion tube 23 can fill or withdraw liquid from the temperature control bag 6. The temperature control system 22 can be a commercially available temperature control device, such as a compressor, condenser, throttle valve, and evaporator. A pressure sensor and a temperature sensor are provided within the temperature control bag 6 to facilitate monitoring of the pressure and temperature of the temperature control bag 6 and prevent damage to the sample due to excessive pressure.

[0041] Please refer to Figure 7-8 Furthermore, a separate upper cover 25 can be provided, connected to the base 1 via a support column 36 connected thereto; an annular chute 26 is provided at the bottom of the separate upper cover 25, to which a rotating cover 27 is slidably connected; a regular hexagonal protrusion is provided at the center of the upper end of the separation disc 2, and a regular hexagonal groove 28 is provided at the bottom of the rotating cover 27 to facilitate rotation of the rotating cover 27. The separate upper cover 25 is provided with an infusion hole 29, and a liquid separation cavity 30 is provided within the rotating cover 27. The infusion tube 23 passes through the infusion hole 29 and is connected to the liquid separation cavity 30 via a bearing 31; the bottom of the rotating cover 27 is provided with a sliding groove 32 that is compatible with the placement groove 4, and a connecting tube 33 is provided on the sliding groove 32. The connecting tube 33 is connected to the liquid separation tank via a liquid separation tube 34. It can be understood that a self-closing valve is provided in the connecting tube 33. When the connecting tube 33 is inserted into the filling port 7, the ejector pin of the filling port 7 is inserted into the connecting tube 33 to open the self-closing valve to connect the liquid separation tank and the temperature control bag 6; a positioning pin 35 is provided on the sliding groove 32 to fix the position of the connecting tube 33 on the sliding groove 32.

[0042] In summary, an embodiment of the present invention provides a blood separation device, which includes a base 1, a separation disc 2 and a power mechanism 3, wherein the separation disc 2 is detachably connected to the power mechanism 3, and the power mechanism 3 is arranged on the base 1; a placement groove 4 is provided on the separation disc 2, and a test tube fixture 5 is provided in the placement groove 4; the test tube fixture 5 includes a clamping member and a temperature control bag 6, and the temperature control bag 6 is annular; the temperature control bag 6 is provided with a filling port 7, and is filled with coolant; and further includes a coolant pressurizing filling device. The present invention provides a placement groove 4 on the separation disc 2, and the sample is fixed by the clamping member on the test tube fixture 5 and then placed in the placement groove 4 for positioning; the annular temperature control bag 6 can effectively fit the sample after being pressurized and filled with coolant, and the sample temperature is controlled and stabilized by heat transfer; at the same time, the staff can use the coolant pressurizing filling device to fill the coolant with a predetermined temperature into it through the filling port 7 of the temperature control bag 6; the detachably connected separation disc 2 and the power mechanism 3 make the replacement and maintenance of the device more convenient.

[0043] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A blood separation device, characterized in that: It includes a base, a separation disc and a power mechanism, the separation disc is detachably connected to the power mechanism, and the power mechanism is arranged on the base; the separation disc is provided with a placement groove, and a test tube fixing piece is provided in the placement groove; the test tube fixing piece includes a clamping piece and a temperature control bag, and the temperature control bag is annular; the temperature control bag is provided with a filling port, and the interior of the bag is filled with coolant; it also includes a coolant pressurized filling device.

2. A blood separation device according to claim 1, characterized in that: A vertical cavity is provided in the test tube fixture, and an opening communicating with the vertical cavity is provided at the upper end of the test tube fixture; the clamping member is provided at the opening, and the temperature control bag is provided in the vertical cavity and connected to the bottom of the clamping member; a vertical through hole is provided on the clamping member, and the filling port passes through the vertical through hole and is fixedly connected thereto.

3. A blood separation device according to claim 2, characterized in that: The clamping member includes a fixed clamp and a movable clamp, and the fixed clamp and the movable clamp are arranged in an arc shape relative to each other; the fixed clamp is fixedly arranged on one side of the opening, and a horizontal slide groove is provided at the opening, and the movable clamp is slidably connected to the horizontal slide groove; a telescopic rod is provided on the side of the movable clamp away from the fixed clamp.

4. A blood separation device according to claim 3, characterized in that: The fixed clamp is arranged on a side away from the center of the separation disc, and the movable clamp is arranged on a side close to the center of the separation disc.

5. A blood separation device according to claim 4, characterized in that: The bottom of the vertical cavity is in an inverted cone shape and is provided with an elastic buffer pad.

6. A blood separation device according to claim 5, characterized in that: The inclination of the tapered bottom of the vertical cavity on a side close to the fixed clamp is greater than that on a side close to the movable clamp.

7. A blood separation device according to claim 1, characterized in that: The placement slot is arranged in a long strip shape along the radial direction of the separation disk, and the outer side of the test tube fixing piece is arranged in a square shape; multiple grooves are evenly arranged on both radial sides of the placement slot, and clamps adapted to the shape of the grooves are arranged on both sides of the test tube fixing piece.

8. A blood separation device according to claim 7, characterized in that: The cross section of the groove is square. A horizontal concave hole is provided on the side of the clamp away from the test tube fixing piece. A top block connected to the bottom of the horizontal concave hole is provided in the horizontal concave hole through a telescopic spring.

9. The blood separation device according to claim 1, characterized in that: The coolant pressure filling device includes a storage tank, which is provided with a temperature regulation system; an infusion tube and an electric pump are provided in the storage tank, and one end of the infusion tube is detachably connected to the filling port.

10. A blood separation device according to claim 9, characterized in that: A pressure sensor and a temperature sensor are arranged in the temperature control bag.

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