Medical pre-disinfection whole-course protective glove and preparation method thereof

Abstract

The invention belongs to the technical field of medical instruments, and discloses a medical pre-disinfection whole-course protective glove and a preparation method thereof.The body of the medical pre-disinfection whole-course protective glove is prepared from a latex outer layer and a medicine-soaked gauze lining layer which are integrally formed; the medicine-soaked gauze lining layer is prepared by soaking medical gauze in ethanol-herbal slow-release disinfection gel and then drying; the ethyl alcohol-herbal slow-release disinfection gel has weak viscosity, and when the ethyl alcohol-herbal slow-release disinfection gel is not used, the upper face and the lower face of the interior of the latex glove body are bonded, air in the latex glove body is emptied, meanwhile, an opening of the latex glove body is closed, and active ingredients are prevented from volatilizing and escaping. According to the invention, extra hand disinfection is not needed, active protection can be provided in the whole process of use by medical personnel, the protection effect is good, the use is convenient, the cost performance is high, and the device can be widely applied to the scenes of high-risk infectious virus sampling, field emergency medical assistance, chemotherapy drug configuration and the like, and has a wide application range.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a pair of medical pre-sterilized full-length protective gloves and a preparation method thereof. Background Art

[0002] Existing medical protective gloves are widely used in various medical settings. Common types include latex gloves, nitrile gloves, PVC gloves, and polyethylene gloves. Latex gloves offer excellent elasticity and a sensitive touch, making them suitable for delicate procedures (such as surgical procedures and sample collection). However, they also suffer from inherent structural strength limitations and a lack of antibacterial and antimicrobial properties. They are prone to breakage during use, and their resistance to needle puncture, chemical penetration, and viral barrier properties are mediocre, failing to simultaneously meet the requirements for fluid absorption, impermeability, and antibacterial properties. Therefore, traditional protective gloves primarily rely on a film layer as a physical barrier. Damage or puncture can pose an infection risk, and they require the use of external disinfectants. When using traditional protective gloves, medical staff must disinfect their hands before donning the gloves, as well as the gloves themselves. This is inconvenient, especially in scenarios requiring "zero penetration" and limited disinfection conditions, such as sampling for high-risk infectious viruses, field emergency medical assistance, and the preparation of chemotherapy drugs. Multiple and thorough disinfection is often impossible, and the overall protective effect falls short of meeting higher protection level standards. Furthermore, the gloves cannot provide active protection throughout the entire process of use.

[0003] To address these problems, some specially manufactured special medical protective gloves have also appeared in the prior art. For example, CN106174814A discloses an antibacterial glove and a preparation method thereof. During preparation, the glove is placed in a pretreatment solution for pretreatment, then immersed in an activation solution for activation, rinsed with pure water, immersed in an antibacterial solution, rinsed with pure water again, and then immersed in a cross-linking solution. Grafting is carried out under ultraviolet light, rinsed with pure water, and finally immersed in the antibacterial solution after the above treatment, rinsed with pure water, and dried in a ventilated place at room temperature to obtain the antibacterial glove. On the one hand, this is based on the existing gloves, with a new preparation process added. The overall process is complicated, and only the antibacterial performance of the product is improved, but the structural strength and overall protection level cannot be improved. Another type of sterile glove disclosed in KR20220077624A has a glove body comprising a three-layer structure of a glove lining, a disinfectant layer and a glove outer layer. The manufacturing process is cumbersome, and the structural strength and protection level are insufficient. Another type of protective glove for chemotherapy disclosed in CN 113057736 A comprises an antibacterial coating, an outer layer (including a cavity), an inner layer and a sweat-absorbing pad. The inner cavity of the outer layer is filled with disinfectant, and the inner side of the inner layer is fixedly connected to the sweat-absorbing pad. The structure is extremely complex and mainly relies on the antibacterial coating to provide external disinfection. When the glove body is damaged, the disinfectant flows out along the damaged area, and the glove is scrapped and cannot be used anymore. The overall cost-effectiveness is low, and it cannot be promoted and applied on a large scale. Summary of the Invention

[0004] In response to the shortcomings of the above-mentioned prior art, the purpose of the present invention is to meet the multiple requirements of disinfection-free, high structural strength, and continuous active protection when carrying out medical activities under severely restricted conditions such as high-risk infectious virus sampling and field emergency medical rescue. On the basis of existing special medical protective gloves, through the coordinated improvement of product structure, formula and process, an ethanol-herbal sustained-release disinfectant gel and a drug-impregnated gauze lining layer integrally formed with the latex layer are introduced, which greatly simplifies the product structure, formula and preparation process. Doctors do not need to disinfect their hands separately before use, nor do they need to disinfect the protective gloves themselves. The structural strength is high and can provide efficient active protection throughout the process of use by medical staff. On the basis of being able to meet the requirements of liquid absorption, impermeability, antibacterial, and comfortable wearing, the disinfectant active ingredients are slowly released and sealed, and the overall protection effect can meet the requirements of high protection level standards. It is particularly suitable for use in scenarios where "zero penetration" and disinfection conditions are limited, such as high-risk infectious virus sampling, field emergency medical rescue, and chemotherapy drug configuration. Deep disinfection of the hands can be achieved in a short time after wearing, and the overall cost is low, and it is easy to promote and use on a large scale to solve the above technical problems.

[0005] The technical solution provided by the present invention to achieve the above-mentioned purpose is: A medical pre-sterilized full-process protective glove comprises a latex glove body, which is prepared from an integrally formed latex outer layer and a medicated gauze lining layer; the medicated gauze lining layer is made by soaking medical gauze in an ethanol-herbal sustained-release disinfectant gel and then drying it; the ethanol-herbal sustained-release disinfectant gel has weak viscosity, and when not in use, the upper and lower surfaces of the latex glove body adhere to each other, thereby evacuating the air inside the latex glove body and sealing the openings of the latex glove body to prevent the active ingredients from volatilizing and escaping; during use, the medicated gauze lining layer slowly releases the active ingredients in the ethanol-herbal sustained-release disinfectant gel, continuously providing active protection.

[0006] The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 70-75% ethanol, 1-2% carboxymethyl chitosan, 2-3% glycerol, 3-5% herbal compound extract, 0.1-0.2% hydrogen peroxide, 0.1-0.2% sodium alginate, 0.02-0.05% β-cyclodextrin-encapsulated baicalin, and the balance being deionized water. The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 8~10%, honeysuckle extract 5~8%, clove extract 3~5%, peppermint extract 1~2%, and the balance is deionized water.

[0007] The volume ratio concentration of ethanol is 95%.

[0008] A method for preparing pre-sterilized medical protective gloves, comprising the following steps: S1: Preparation of ethanol-herbal slow-release disinfectant gel First, a herbal compound extract solution is prepared, and then a carboxymethyl chitosan gel solution is prepared. Then, the herbal compound extract solution, the carboxymethyl chitosan gel solution, ethanol, glycerol, sodium alginate, β-cyclodextrin-encapsulated baicalin, and hydrogen peroxide are sequentially added to deionized water at low temperature and homogenized. S2. Preparation of drug-soaked gauze lining layer The medical gauze is surface-pretreated, then immersed in an ethanol-herbal sustained-release disinfectant gel, vacuumed, taken out, dried at low temperature, and cut into gauze patches matching the mold; S3, Dipping Molding The cut gauze patch is attached to the mold surface, and the mold and the gauze patch are immersed in a dilute latex solution and quickly taken out. The gauze patch and the dilute latex solution together form a composite lining layer; then the mold is immersed in a high-solid content latex solution and quickly taken out to form a latex outer layer of moderate thickness; S4, vulcanization cross-linking Firstly, low-temperature drying and pre-vulcanization are carried out, and then microwave vulcanization is carried out to quickly cross-link the composite lining layer and the latex outer layer to complete the one-piece molding; S5. Post-processing The process is followed by crimping, demoulding, venting, quality inspection, sterilization and finally sealing and packaging.

[0009] The medical pre-sterilized full-length protective gloves and the preparation method thereof provided by the present invention have the following beneficial effects compared with the prior art: 1. The protective gloves and preparation method provided by the present invention are based on the existing special medical protective gloves. They meet the requirements of disinfection-free, high structural strength, continuous active protection, etc. when carrying out medical activities under severely restricted conditions such as high-risk infectious virus sampling and field emergency medical assistance. Through the coordinated improvement of product structure, formula and process, the product structure, formula and preparation process are greatly simplified by introducing ethanol-herbal sustained-release disinfectant gel and a drug-soaked gauze lining layer integrally formed with the latex layer. Doctors do not need to disinfect their hands before use, nor do they need to disinfect the protective gloves themselves. They can be worn for a short time without any problem. It only takes a short time (usually within 2-3 minutes) to achieve deep and thorough disinfection of the hands without the need for additional configuration and carrying of disinfectant. The protective gloves have high structural strength and can provide efficient active protection for medical staff throughout the entire process of use. In addition, on the basis of being able to meet the requirements of liquid absorption, impermeability, antibacterial, and comfortable wearing, the overall protection effect can meet the requirements of high protection level standards. They are particularly suitable for use in scenarios requiring "zero penetration" and limited disinfection conditions, such as high-risk infectious virus sampling, field emergency medical assistance, and chemotherapy drug configuration. They are easy to store, carry and use, and have a low overall cost, making them easy to promote and use on a large scale.

[0010] 2. The ethanol-herbal sustained-release disinfectant gel used in the present invention has good compatibility between the various components and a high ethanol content. It is compounded with active ingredients such as hydrogen peroxide under alkaline conditions, and has stable sustained-release, broad-spectrum, and rapid disinfection effects without irritating the skin. It can focus on the needs of high-risk viruses / toxic environments, as well as emergency rescue and other scenarios with limited disinfection conditions. It adopts sustained-release and active protection, and slowly releases the disinfection active ingredients during use, ensuring that highly diffusive bacteria entering from the cuff can also be intercepted outside the internal space of the glove, or the bacteria that enter the internal space can be quickly killed, which can fill the gap in the field of high-risk virus protection of existing medical gloves.

[0011] 3. The product and preparation method provided by the present invention are characterized by the following main processes: a combination of ethanol-herbal sustained-release disinfectant gel + impregnated gauze lining + step-by-step impregnation + low-temperature vulcanization + post-treatment is prepared in advance, which achieves a stable combination of gauze and ethanol-herbal sustained-release disinfectant gel and a higher active ingredient load; on the other hand, it also improves the interfacial strength of the latex and gauze, allowing the gauze lining and the latex outer layer to be stably compounded, while improving the structural strength and active protection capability of the gloves. The gloves can maintain structural integrity and internal sealing when encountering large mechanical wear, tearing, and acupuncture; and finally, it can ensure that the active ingredient loss in the ethanol-herbal sustained-release disinfectant gel is small, and can be continuously released in the confined space inside the gloves during use to maintain an effective disinfection concentration. Compared with traditional medical protective gloves and their preparation processes, the product of the present invention has the three advantages of active protection, environmental protection and safety, and comfortable wearing. It can replace traditional disinfectants, and the manufacturing process is compact, easy to mass-produce, and the cost is controllable. The comprehensive cost of a single pair of gloves is less than 2.5 yuan during mass production.

[0012] 4. The medical protective gloves provided by the present invention can meet the requirements of the second category medical device standards. By introducing a gauze lining layer that absorbs ethanol-herbal sustained-release disinfectant gel and controlling the overall thickness, it can ensure the convenience of medical staff when collecting virus samples or handling other toxic items. At the same time, the inside of the gloves can maintain a high disinfection concentration and protective state throughout the process, protecting the hands of medical staff from toxic substances and completely isolating them. It can also prevent bacteria from entering through the openings or damaged parts of the gloves and contacting the human body. The gauze lining layer, on the one hand, carries the condensed liquid, and on the other hand, can enhance the protective effect and prevent damage to the rubber layer of the gloves.

[0013] 5. The medical protective gloves provided by the present invention use an ethanol-herbal sustained-release disinfectant gel which mainly contains ethanol and Chinese herbal medicine extracts. The gel is pre-soaked in the gauze of the inner lining of the gloves and then dried to keep them dry and stored in a sealed manner. When in use, medical staff can wear the gloves directly in low-risk areas without having to disinfect their hands in advance. They can thoroughly disinfect their hands inside the gloves and maintain a high disinfection concentration before going to high-risk areas for sampling, treatment, and other medical activities. During this process, any bacteria or viruses that enter the gloves can be killed at any time. After use, the medical staff can directly remove the gloves when returning to the low-risk area. At this time, there is no need to perform other special protective operations such as hand disinfection. This greatly reduces the protective supplies required for medical staff entering and leaving high-risk areas and simplifies the protective operation process.

[0014] 6. The medical protective gloves provided by the present invention use an ethanol-herbal sustained-release disinfectant gel with a sustained-release composite enhanced bactericidal effect, which can effectively kill a variety of common pathogenic bacteria, viruses and other microorganisms. Ethanol is the main disinfectant ingredient, and Chinese herbal extracts can enhance the antibacterial effect. Carboxymethyl chitosan has sustained-release properties and weak viscosity, which can prolong the action time of the disinfectant ingredients and make it easy for the gauze to fit tightly to the mold surface to form the glove lining layer; carboxymethyl chitosan, glycerol and Chinese herbal extracts can all improve the moisturizing performance of the lining layer, improve odor, and reduce the irritation of the lining layer to the skin.

[0015] 7. After actual testing, the products and preparation processes provided by the present invention have broken through the limitations of existing similar products and applications. They can be widely used in scenarios requiring "zero penetration" such as high-risk infectious virus sampling, field emergency medical assistance, and chemotherapy drug configuration. There is no need to carry other hand disinfection products. It has a wide range of applications and low overall cost, which facilitates large-scale, low-cost promotion and popularization. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the outline structure of the medical pre-sterilized full-length protective gloves prepared according to an embodiment of the present invention.

[0017] Figure 2 This is a schematic diagram of the planar unfolding structure of the medicated gauze lining layer in the medical pre-sterilized full-length protective gloves prepared according to an embodiment of the present invention.

[0018] Figure 3 A schematic diagram of the three-dimensional structure of the medical pre-sterilized full-process protective gloves prepared according to an embodiment of the present invention; Figure 4 A schematic diagram of the three-dimensional appearance structure of the medical pre-sterilized full-length protective gloves prepared in accordance with an embodiment of the present invention from another perspective; Figure 5 This is a schematic diagram of the use status of the medical pre-sterilized full-process protective gloves prepared according to an embodiment of the present invention. DETAILED DESCRIPTION

[0019] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the technical solutions of the present invention are further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only intended to illustrate the present invention and are not intended to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

[0020] Basic Example See also Figure 1-Figure 2The medical pre-sterilized full-length protective latex gloves provided in this embodiment are available in sizes XS, S, M, L, XL, or XXL. The pre-sterilized full-length protective medical gloves comprise a latex glove body 1, which is formed from an integrally formed latex outer layer 2 and a medicated gauze lining layer 3. The medicated gauze lining layer 3 is made by soaking medical gauze in an ethanol-herbal sustained-release disinfectant gel and then drying it. The ethanol-herbal sustained-release disinfectant gel has weak viscosity. When not in use, the upper and lower surfaces of the latex glove body adhere to each other, evacuating the air inside the glove body and sealing the openings of the latex glove body to prevent the active ingredients from volatilizing and escaping. During use, the medicated gauze lining layer 3 slowly releases the active disinfectant ingredients in the ethanol-herbal sustained-release disinfectant gel, continuously providing active protection. This can rapidly kill bacteria / viruses on the hands of medical personnel, as well as bacteria / viruses that enter the glove from the wrist, preventing them from contacting human skin.

[0021] The medical gauze is a hollow polyester / cotton composite gauze that has been treated with plasma surface activation. The gauze can be selected according to needs, and high-count and high-density combed cotton gauze is preferred.

[0022] In each embodiment, the specific selection of medical gauze can comprehensively consider design factors such as application scenario (e.g., liquid absorption, impermeability, antibacterial), mechanical properties (strength, elasticity), and regulatory compliance (YY / T, USP, EN standards), while also taking into account water absorption, breathability, and strength. Surface modification (e.g., plasma treatment) can be used to improve the adsorption uniformity of the ethanol-herbal sustained-release disinfectant gel. In each embodiment of the present invention, hollow polyester / cotton composite yarn can be specifically selected. This hollow polyester / cotton composite yarn has a better synergistic effect with the ethanol-herbal sustained-release disinfectant gel, with a high adsorption capacity. It is suitable for applications requiring rapid adsorption and breathability, high humidity, or prolonged operation, ensuring that the active ingredients adsorbed within the glove can maintain an effective sterilizing concentration over time.

[0023] The drug-impregnated gauze lining layer 3 of each glove comprises an upper piece 31 and a lower piece 32 in a symmetrical structure, which, after being vulcanized and formed with the latex outer layer 1, form the upper and lower surfaces with weak adhesiveness inside the latex glove body 1 .

[0024] The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 70-75% ethanol, 1-2% carboxymethyl chitosan, 2-3% glycerol, 3-5% herbal compound extract, 0.1-0.2% hydrogen peroxide, 0.1-0.2% sodium alginate, 0.02-0.05% β-cyclodextrin-encapsulated baicalin, and the balance being deionized water. The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 8~10%, honeysuckle extract 5~8%, clove extract 3~5%, peppermint extract 1~2%, and the balance is deionized water.

[0025] The volume ratio concentration of ethanol is 95%.

[0026] A method for preparing pre-sterilized medical protective gloves comprises the following steps: S1: Preparation of ethanol-herbal slow-release disinfectant gel First, a herbal compound extract is prepared, and then a carboxymethyl chitosan gel solution is prepared. Then, at low temperature, the herbal compound extract, the carboxymethyl chitosan gel solution, ethanol, glycerol, sodium alginate, β-cyclodextrin-encapsulated baicalin, and hydrogen peroxide are sequentially added to deionized water for homogenization. The method specifically comprises the following steps: S1-1: Preparation of raw materials Ethanol, carboxymethyl chitosan, glycerol, hydrogen peroxide, scutellaria baicalensis extract, honeysuckle extract, clove extract, mint extract, sodium alginate, β-cyclodextrin-encapsulated baicalin (baicalin-β-cyclodextrin inclusion complex), and deionized water were prepared respectively; S1-2: Preparation of herbal compound extracts Add the scutellaria baicalensis extract, honeysuckle extract, clove extract, and mint extract to the remaining amount of deionized water, and homogenize at 1500-2000 rpm for 5-10 minutes to obtain a herbal composite extract; S1-3: Preparation of carboxymethyl chitosan gel solution Carboxymethyl chitosan is added to an appropriate amount of deionized water, stirred continuously until the carboxymethyl chitosan is completely dissolved, and the pH value is adjusted to 6.0-7.0 to obtain a carboxymethyl chitosan gel solution. This preparation method can effectively improve the solubility of chitosan, and synergize with sodium alginate and β-cyclodextrin-encapsulated baicalin to improve the dispersion uniformity and sustained-release effect of the active ingredients in the disinfectant gel formula. Secondly, the pH value of the final disinfectant gel is adjusted to less than 7 (the herbal composite extract is also alkaline), and the alkaline environment improves the stability of hydrogen peroxide. S1-4: Preparation of ethanol-herbal slow-release disinfectant gel Carboxymethyl chitosan gel, glycerol, herbal compound extract, sodium alginate, β-cyclodextrin-encapsulated baicalin, and ethanol were added to deionized water and homogenized at 1500-2000 rpm for 10-20 minutes. Finally, hydrogen peroxide was added and homogenized again at 1500-2000 rpm for 5-10 minutes to obtain an ethanol-herbal sustained-release disinfectant gel, which was then allowed to stand at a low temperature of no more than 15°C for use. S2. Preparation of drug-soaked gauze lining layer The medical gauze is surface pretreated, then immersed in ethanol-herbal slow-release disinfectant gel, vacuumed, taken out and dried at low temperature, and cut into gauze patches matching the mold; the specific steps include: S2-1: Pretreatment of medical gauze Plasma surface activation treatment is performed on medical gauze. Low-temperature plasma is used to activate the fiber surface and introduce hydrophilic groups such as hydroxyl groups (-OH) to optimize the porosity of the gauze to balance adsorption capacity and air permeability. Specifically, a plasma grafting polymerization (PGP) treatment process can be used. First, plasma is used to activate the gauze fiber surface and introduce active groups. Then, new active branches are attached to the fiber surface through grafting polymerization reaction to form a new surface layer, thereby simultaneously improving the adsorption capacity and air permeability of the disinfectant gel. S2-2: Vacuum impregnation Immerse the pretreated medical gauze in the ethanol-herbal sustained-release disinfectant gel, evacuate the area, maintain the vacuum at -0.08 MPa, and immerse for 3 to 5 minutes to allow the disinfectant gel to fully penetrate into the fibers of the medical gauze. S2-3: Low temperature drying Dry with hot air circulation at no more than 40°C for 20-30 minutes to control the final moisture content to 5-8wt%; S2-4: Symmetrical cutting Cut the medical gauze into upper and lower pieces that match the shape and size of the glove mold and have a symmetrical structure; S3, Dipping Molding The cut gauze patch is attached to the mold surface, and the mold and the gauze patch are immersed in a dilute latex solution and quickly taken out. The gauze patch and the dilute latex solution form a composite lining layer; and then immersed in a high-solid content latex solution and quickly taken out to form a latex outer layer of moderate thickness. The specific steps include: S3-1: Gauze lining fitting First, prepare a mold (usually made of ceramic or aluminum, shaped to match your hand) and clean it. Then, attach the pre-treated gauze lining, including the upper and lower sheets, directly to the upper and lower surfaces of the mold using their own weak adhesive properties. S3-2: First Dipping Immerse the mold and the gauze lining as a whole in a dilute latex solution with a solid content of 15-20wt% for 5-10 seconds, allowing the dilute latex solution to fully penetrate the cotton yarn of the gauze lining and the gaps between the cotton yarns to form a composite lining layer; S3-3: Second dipping Then immerse in a latex solution with a solid content of 30-35 wt% for 10-15 seconds to form a latex outer layer with a thickness of 0.2-0.5 mm; The latex liquid and the diluted latex liquid are both made by mixing natural latex and nitrile rubber in a mass ratio of 7:3, and are filtered and stabilized, and then appropriately added with additives, such as a vulcanizing agent (such as sulfur), an accelerator (such as zinc oxide), an anti-aging agent, etc., to enhance the stability, elasticity and durability of the latex; S3-4: Leaching Rinse the impregnated mold with hot water to remove water-soluble proteins on the outer surface of the latex layer (to reduce the risk of allergies) and excess additives; In this step, if the medical gauze used is too thin or the mesh is too sparse, a mold pretreatment step may also be included. Before S3-1, the hand mold is pre-immersed in a coagulant solution (such as a 5wt% solution of calcium nitrate, calcium carbonate, or calcium acetate) to form an isolation layer to avoid difficulty in demolding after vulcanization. At the same time, it can also allow the latex that passes through the gauze mesh to evenly adhere to the mold surface.

[0027] During the dipping process, the thickness of the inner lining layer and the outer film can be adjusted by controlling the dipping time (usually several seconds to tens of seconds) of the mold and the gauze lining as a whole into the latex solution, as well as the number of dipping times. However, usually one dipping of each is sufficient to meet the requirements.

[0028] S4, vulcanization cross-linking First, low-temperature drying and pre-vulcanization are carried out, and then microwave vulcanization is carried out to quickly cross-link the composite lining layer and the latex outer layer to complete the one-piece molding; the specific steps include: S4-1: Low temperature drying and pre-vulcanization Use hot air of no more than 70℃ to heat and dry the wet film, pre-vulcanize it, make some latex molecules undergo cross-linking reaction, preliminarily set the shape, and dry the latex outer layer; S4-2: Microwave vulcanization Maintain rapid microwave vulcanization at a low temperature of no more than 70°C to quickly cross-link the composite lining layer and the latex outer layer to complete the one-piece molding and ensure that the latex of the composite lining layer is fully cured; Specifically, low-temperature rapid microwave vulcanization is performed at a frequency of 2.45 GHz and a power of 5-10 kW. The vulcanization temperature is controlled below 70°C and the vulcanization time is 3-5 minutes. This allows the composite inner lining layer and the latex outer layer to be rapidly cross-linked, completing the integral molding. Microwave vulcanization ensures that the inner latex layer is fully cured. After the final vulcanization is completed, the cross-linking of the molecular chains of the inner and outer latex layers can improve the mechanical properties and chemical resistance of the integral molding. S5. Post-processing The following steps are carried out in sequence: crimping, demoulding, exhaust, quality inspection, sterilization, and finally sealing and packaging: S5-1: Hemming: Fold the wrist edge of the glove inward 1-2 times to form a neat hem structure. This can be done by mechanical hemming, a rotating brush or roller device to fold the wrist edge of the glove inward 1-2 times to form a neat hem structure (to enhance the seal and prevent the edge from tearing during wear). Finally, heat setting is performed. After hemming, the shape is fixed by briefly heating (70-90℃) to ensure the edge is firm. S5-2: Demolding: Slowly peel the glove from the mold along the mold's axis. Automated equipment can be used to partially loosen the glove from the mold (especially around the fingers) by using compressed air or water. Then, a robotic arm can be used to grip the edge of the glove and slowly peel it along the mold's axis to avoid tearing. S5-3: Drying: Use hot air below 70°C to dry the outer surface of the gloves; S5-4: Quality inspection: Perform inflation leak detection, tensile strength test, thickness uniformity test and visual inspection (no holes or impurities required); S5-5: Exhaust: Press the entire glove flat to fit the top and bottom of the glove tightly together, exhaust the air inside the glove, and seal the internal space of the glove to prevent the volatilization and escape of active ingredients such as ethanol; S5-6: Sterilization: ethylene oxide (EO) sterilization, temperature 50°C, humidity 60%, EO concentration 600 mg / L, sterilization time 4 hours; S5-7: Sealed packaging: Each glove should be packaged separately and sealed; specifically, plastic sealing or aluminum foil vacuum packaging can be used to isolate the air and prevent the disinfectant active ingredients inside the gloves from being oxidized during storage.

[0029] The composite formula of alcohol (ethanol)-carboxymethyl chitosan-Chinese herbal medicine extract provided in the embodiment of the present invention performs best after comprehensive comparison with many other similar formulas, has good bactericidal effect, good sustained-release performance, and is skin-friendly. At the same time, the preparation process is relatively simple and easy to mass produce.

[0030] The following describes the details with reference to several specific embodiments.

[0031] Example 1 See also Figure 3-Figure 4 The medical pre-sterilized full-length protective gloves and their preparation method provided in this embodiment are a specific selection and application of the basic embodiment. The structure of the medical pre-sterilized full-length protective gloves is exactly the same as that of the basic embodiment, except that: Medical gauze specifically selects high count and high density combed cotton gauze, Ne 40 / 1, warp and weft density 24×20; The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 70% ethanol, 1.5% carboxymethyl chitosan, 2% glycerol, 3% herbal compound extract, 0.15% hydrogen peroxide, 0.1% sodium alginate, 0.02% β-cyclodextrin-encapsulated baicalin, and the balance deionized water; The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 8%, honeysuckle extract 6.5%, clove extract 4.5%, peppermint extract 1.5%, and the balance is deionized water.

[0032] The medical pre-sterilized full-protection latex gloves provided in this embodiment are of medium size (M type), with a rolled edge circumference of 20-22 cm and a total thickness of the inner and outer layers of approximately 0.3-0.4 mm. They are highly versatile and can cover most adults. Figure 3-Figure 4 The figure is a schematic diagram of the three-dimensional outline structure of the latex glove product prepared in this embodiment. The texture of the gauze in the composite lining layer can be seen clearly through the outer latex layer. Some of the raised textures also form surface lines on the outer latex layer, increasing the friction of the outer layer and improving the anti-slip ability, significantly enhancing the structural strength and operational flexibility of the glove product.

[0033] Example 2 See also Figure 5 The medical pre-sterilized full-length protective gloves and the preparation method thereof provided in this embodiment are substantially the same as those in Example 1, except that: The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 72.5% ethanol, 1% carboxymethyl chitosan, 2.5% glycerol, 3.5% herbal compound extract, 0.1% hydrogen peroxide, 0.15% sodium alginate, 0.05% β-cyclodextrin-encapsulated baicalin, and the balance deionized water; The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 9.5%, honeysuckle extract 5%, clove extract 3.5%, peppermint extract 2%, and the balance is deionized water.

[0034] The medical pre-sterilized, full-protective latex gloves provided in this embodiment are specifically XL-sized: the hem circumference is 25 cm or greater, and the wrist is extended. The total thickness of the inner and outer layers is approximately 0.4-0.6 mm, to accommodate higher levels of protection and other special needs. As can be seen from the figure, when in use, these medical pre-sterilized, full-protective gloves can completely cover the hands and wrists of medical personnel, allowing for a greater amount of sustained-release disinfectant gel to be carried, thereby enhancing disinfection and protection. The texture of the gauze lining of the composite inner lining layer penetrates through the outer latex layer to form a surface pattern on the outer latex layer, increasing surface friction and making the gloves non-slip.

[0035] Example 3 The medical pre-sterilized full-length protective gloves and the preparation method thereof provided in this embodiment are substantially the same as those in Examples 1 and 2, except that: The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 75% ethanol, 2% carboxymethyl chitosan, 3% glycerol, 5% herbal compound extract, 0.2% hydrogen peroxide, 0.2% sodium alginate, 0.03% β-cyclodextrin-encapsulated baicalin, and the balance deionized water; The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 10%, honeysuckle extract 7.5%, clove extract 3%, peppermint extract 1%, and the balance is deionized water.

[0036] Example 4 The medical pre-sterilized full-length protective gloves and the preparation method thereof provided in this embodiment are substantially the same as those in Examples 1 to 3, except that: The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 74% ethanol, 1.75% carboxymethyl chitosan, 2.75% glycerol, 4.5% herbal compound extract, 0.15% hydrogen peroxide, 0.16% sodium alginate, 0.04% β-cyclodextrin-encapsulated baicalin, and the balance deionized water; The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 8.5%, honeysuckle extract 8%, clove extract 5%, peppermint extract 1.75%, and the balance is deionized water.

[0037] The preparation processes and products provided in the above-mentioned embodiments of the present invention can be mass-produced through a highly automated production line, and the products can simultaneously meet the requirements of medical gloves such as protection, comfort, and biosafety.

[0038] The pre-sterilized medical protective gloves provided by the above-mentioned embodiments of the present invention have been tested and successfully passed the EN 455 series of tests (non-porosity, physical properties, and biological evaluation). They comply with the following domestic standards: GB7543-2006 Material and Technical Requirements for Sterilized Rubber Surgical Gloves; GB 10213-2006 Technical Specifications for Medical Rubber Examination Gloves; and GB 24788-2009 Limits for Residual Powder and Protein on Glove Surfaces, and are therefore suitable for industrial application.

[0039] It should be noted that in other embodiments of the present invention, within the scope of the product shape, structure, formula components, ratios, preparation steps, process parameters and conditions recorded in the present invention, other different schemes obtained by specific selection can achieve the technical effects recorded in the present invention, so the present invention will no longer list them one by one.

[0040] The above description is merely a preferred embodiment of the present invention and does not constitute any form of limitation to the present invention. Any person skilled in the art can utilize the methods and techniques disclosed above to make numerous possible variations and modifications to the present invention, or to create equivalent embodiments with equivalent variations, without departing from the scope of the present invention. Any equivalent variations based on the components, proportions, and processes of the present invention are intended to be encompassed within the scope of the present invention.

Claims

1. A medical pre-sterilized full-process protective glove, characterized in that: The invention comprises a latex glove body (1), which is made of an integrally formed latex outer layer (2) and a drug-soaked gauze lining layer (3); the drug-soaked gauze lining layer (3) is made of medical gauze soaked in ethanol-herbal slow-release disinfectant gel and then dried; the ethanol-herbal slow-release disinfectant gel has weak viscosity, and when not in use, the upper and lower parts of the latex glove body are bonded together, thereby evacuating the air inside the latex glove body and sealing the opening of the latex glove body to prevent the active ingredients from volatilizing and escaping; during use, the drug-soaked gauze lining layer (3) slowly releases the active ingredients in the ethanol-herbal slow-release disinfectant gel, continuously providing active protection.

2. The medical pre-sterilized full-length protective gloves according to claim 1, characterized in that: The ethanol-herbal sustained-release disinfectant gel is made of the following components in percentage by mass: 70-75% ethanol, 1-2% carboxymethyl chitosan, 2-3% glycerol, 3-5% herbal compound extract, 0.1-0.2% hydrogen peroxide, 0.1-0.2% sodium alginate, 0.02-0.05% β-cyclodextrin-encapsulated baicalin, and the balance being deionized water. The herbal compound extract is made of the following components in the following mass percentages: Scutellaria baicalensis extract 8-10%, honeysuckle extract 5-8%, clove extract 3-5%, peppermint extract 1-2%, and the balance is deionized water; The volume ratio concentration of ethanol is 95%.

3. The medical pre-sterilized full-protection gloves according to claim 1, characterized in that: The medical gauze is a hollow polyester / cotton composite gauze that has been subjected to low-temperature plasma surface activation treatment.

4. The medical pre-sterilized full-protection gloves according to claim 1, characterized in that: The drug-impregnated gauze lining layer (3) of each glove comprises an upper piece (31) and a lower piece (32) of a symmetrical structure, which, after being vulcanized and formed with the latex outer layer (1), form the upper and lower surfaces with weak adhesiveness inside the latex glove body (1).

5. A method for preparing pre-sterilized medical protective gloves, characterized in that: It includes the following steps: S1: Preparation of ethanol-herbal slow-release disinfectant gel First, a herbal compound extract solution is prepared, and then a carboxymethyl chitosan gel solution is prepared. Then, the herbal compound extract solution, the carboxymethyl chitosan gel solution, ethanol, glycerol, sodium alginate, β-cyclodextrin-encapsulated baicalin, and hydrogen peroxide are sequentially added to deionized water at low temperature and homogenized. S2. Preparation of drug-soaked gauze lining layer The medical gauze is surface-pretreated, then immersed in an ethanol-herbal sustained-release disinfectant gel, vacuumed, taken out, dried at low temperature, and cut into gauze patches matching the mold; S3, Dipping Molding The cut gauze patch is attached to the mold surface, and the mold and the gauze patch are immersed in a dilute latex solution and quickly taken out. The gauze patch and the dilute latex solution together form a composite lining layer; then the mold is immersed in a high-solid content latex solution and quickly taken out to form a latex outer layer of moderate thickness; S4, vulcanization cross-linking Firstly, low-temperature drying and pre-vulcanization are carried out, and then microwave vulcanization is carried out to quickly cross-link the composite lining layer and the latex outer layer to complete the one-piece molding; S5. Post-processing The process is followed by crimping, demoulding, venting, quality inspection, sterilization and finally sealing and packaging.

6. The method for preparing the medical pre-sterilized full-length protective gloves according to claim 5, characterized in that: S1 specifically includes the following steps: S1-1: Preparation of raw materials Ethanol, carboxymethyl chitosan, glycerol, hydrogen peroxide, scutellaria baicalensis extract, honeysuckle extract, clove extract, mint extract, sodium alginate, β-cyclodextrin-encapsulated baicalin, and deionized water were prepared respectively; S1-2: Preparation of herbal compound extracts Adding scutellaria baicalensis extract, honeysuckle extract, clove extract, and mint extract to the remaining amount of deionized water, and homogenizing to obtain a herbal composite extract; S1-3: Preparation of carboxymethyl chitosan gel solution Add carboxymethyl chitosan to an appropriate amount of deionized water, continue stirring until the carboxymethyl chitosan is completely dissolved, and adjust the pH value to 6.0-7.0 to obtain a carboxymethyl chitosan gel solution; S1-4: Preparation of ethanol-herbal slow-release disinfectant gel Carboxymethyl chitosan gel, glycerol, herbal compound extract, sodium alginate, β-cyclodextrin-encapsulated baicalin, and ethanol are added to deionized water and homogenized. Finally, hydrogen peroxide is added and homogenized again to obtain an ethanol-herbal sustained-release disinfection gel, which is then allowed to stand at low temperature for use.

7. The method for preparing the medical pre-sterilized full-length protective gloves according to claim 5, characterized in that: S2 specifically includes the following steps: S2-1: Pretreatment of medical gauze Plasma surface activation treatment of medical gauze; S2-2: Vacuum impregnation Immerse the pretreated medical gauze in ethanol-herbal slow-release disinfectant gel and vacuum; S2-3: Low temperature drying Dry with hot air circulation at no more than 40°C to control the final moisture content to 5~8wt%; S2-4: Symmetrical cutting Cut the medical gauze into upper and lower pieces that match the shape and size of the glove mold and have a symmetrical structure.

8. The method for preparing the medical pre-sterilized full-length protective gloves according to claim 5, characterized in that: S3 specifically includes the following steps: S3-1: Gauze lining fitting The pre-treated and cut gauze lining, including the upper and lower sheets, is attached to the mold surface using its own weak adhesiveness; S3-2: First Dipping Immerse the mold and the gauze lining as a whole in a dilute latex solution with a solid content of 15-20wt%, allowing the dilute latex solution to fully penetrate the cotton yarns of the gauze lining and the gaps between the cotton yarns to form a composite lining layer; S3-3: Second dipping Then immerse it in a latex solution with a solid content of 30-35w to form a latex outer layer with a thickness of 0.2-0.5 mm; S3-4: Leaching The mold after dipping is rinsed with hot water to remove water-soluble proteins and excess additives on the outer surface of the latex layer.

9. The method for preparing the medical pre-sterilized full-length protective gloves according to claim 5, characterized in that: S4 specifically includes the following steps: S4-1: Low temperature drying and pre-vulcanization Use hot air no higher than 80℃ to heat and dry the wet film, pre-vulcanize it, make some latex molecules undergo cross-linking reaction, preliminarily set the shape, and dry the latex outer layer; S4-2: Microwave vulcanization Maintain rapid microwave vulcanization at a low temperature of no more than 80°C to quickly cross-link the composite lining layer and the latex outer layer to complete the one-piece molding and ensure that the latex of the composite lining layer is completely cured.

10. The method for preparing the medical pre-sterilized full-length protective gloves according to claim 5, characterized in that: S5 specifically includes the following steps: S5-1: Demolding: Slowly peel the glove from the mold along the mold axis; S5-2: Rolling: Fold the wrist edge of the glove inward 1~2 times to form a neat rolled edge structure; S5-3: Drying: Use hot air below 70℃ to dry the outer surface of the gloves S5-4: Quality inspection: perform inflation leak detection, tensile strength test, thickness uniformity test and visual inspection; S5-5: Exhaust: Press the entire glove flat to make the top and bottom of the glove fit tightly together and exhaust the air inside the glove. S5-6: Sterilization: Ethylene oxide sterilization; S5-7: Sealed packaging: Each glove should be packaged individually and sealed.

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