Mild resident whitening composition suitable for wash-off products as well as preparation method and application of mild resident whitening composition

Abstract

The invention provides a mild resident whitening composition suitable for a wash-off product as well as a preparation method and application of the mild resident whitening composition, and the mild resident whitening composition is prepared from the following components in parts by weight: 0.01 to 1 part of oxyresveratrol, 1 to 8 parts of bentonite, 0.1 to 10 parts of polyquaternium-7, 0.1 to 10 parts of 1, 3-propylene glycol and 0.1 to 5 parts of tocopheryl acetate. Through bentonite interlayer confinement adsorption and a polyquaternium-7 hydrogen bond-cation synergistic anchoring mechanism and in combination with a 1, 3-propylene glycol-tocopheryl acetate double-effect stabilizing system, the whitening and brightening effects of efficient active matter residence are achieved, and the whitening and brightening composition is stable, non-degradable, mild and non-irritant in a weakly acidic environment and a surfactant system and has a good application prospect. The composition is suitable for people with sensitive skin.

Description

Technical Field

[0001] The present invention belongs to the field of cosmetics, and in particular relates to a mild leave-in whitening composition suitable for rinse-off products, and a preparation method and application thereof. Background Art

[0002] As a natural diphenylethylene derivative, resveratrol oxide can effectively neutralize free radicals, inhibit melanin synthesis and enhance skin barrier repair function due to its polyphenolic hydroxyl and olefin conjugated structure. However, in rinse-off products, the phenolic hydroxyl and olefin bonds in its molecules are easily affected by the stripping effect of surfactant micelles. The hydrophilic end of the surfactant destroys the stability of the phenolic hydroxyl group through hydrogen bond competition, and the hydrophobic chain induces olefin bond configuration isomerization, resulting in degradation and inactivation of the active ingredient. In addition, the short contact time and water flushing make it difficult for it to effectively stay on the skin and exert its effect.

[0003] Current technologies mainly rely on liposome encapsulation or bentonite adsorption to improve retention, but liposomes are prone to membrane fusion and rupture in a surfactant environment, and bentonite physical adsorption has limited affinity for non-ionic active substances, and high addition levels can easily lead to excessive viscosity of the system; although cationic polymers can enhance retention through electrostatic film formation, the adsorption efficiency is greatly weakened under weakly acidic conditions due to insufficient dissociation of active substances, and neither method has effectively solved the problem of molecular structure instability caused by surfactants. Summary of the Invention

[0004] The purpose of the present invention is to provide a mild resident whitening composition, which can improve the resident effect of oxidized resveratrol, reduce the influence of surfactants, and improve its stability in a weak acid environment.

[0005] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0006] A mild leave-on whitening composition comprising the following components in parts by weight:

[0007] 0.01-1 parts by weight of resveratrol oxide, 1-8 parts by weight of bentonite, 0.1-10 parts by weight of polyquaternium-7, 0.1-10 parts by weight of 1,3-propylene glycol, and 0.1-5 parts by weight of tocopheryl acetate.

[0008] The amount of the resveratrol oxide is preferably 0.05 to 0.5 parts by weight, more preferably 0.1 parts by weight.

[0009] The bentonite is preferably present in an amount of 2 to 5 parts by weight, more preferably 3 parts by weight.

[0010] The polyquaternium-7 is preferably 1 to 5 parts by weight, more preferably 3 parts by weight.

[0011] The amount of the 1,3-propylene glycol is preferably 1 to 5 parts by weight, more preferably 3 parts by weight.

[0012] The tocopherol acetate is preferably in an amount of 0.3 to 1 part by weight, more preferably 0.5 part by weight.

[0013] In the present invention, the bentonite is at least one of sodium bentonite, calcium bentonite, and organic bentonite, preferably sodium bentonite. Bentonite acts as a physical adsorption carrier, capturing and storing oxidized resveratrol through its interlayer structure, thereby reducing flushing loss.

[0014] Polyquaternium-7 (PQ-7) forms a water-locking retention layer on the skin surface through cationic film formation and hydrogen bond anchoring, enhancing the adhesion of active ingredients.

[0015] 1,3-Propanediol acts as a solvent and stabilizing medium, dissolving oxidized resveratrol and forming a protective hydrogen bond network to prevent the active ingredient from degradation.

[0016] Tocopheryl acetate acts as a free radical scavenger, blocking the oxidation chain reaction and protecting the phenolic hydroxyl structure of oxidized resveratrol from being destroyed.

[0017] The preparation method of the mild leave-on whitening composition of the present invention comprises the following steps:

[0018] dissolving resveratrol oxide and tocopheryl acetate in 1,3-propylene glycol;

[0019] Disperse bentonite with 3 to 5 parts by weight of deionized water;

[0020] Mix the above two evenly, finally add polyquaternium-7, and continue mixing evenly to obtain the product.

[0021] The mild leave-on whitening composition of the present invention can be applied to whitening products, including but not limited to facial cleansers and sunscreens.

[0022] As one of its applications, the present invention proposes a facial cleanser, which includes the following raw materials in the following weight percentages: 10%-20% of a mild leave-on whitening composition, 1%-10% of a moisturizer, 10%-30% of a surfactant, 0.01%-0.3% of a pH regulator, 0.01%-0.3% of a thickener, and the balance is deionized water.

[0023] Preferably, the moisturizing agent includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butylene glycol, 1,3-propylene glycol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine, allantoin, sodium polyacrylate, and hydrogenated lecithin.

[0024] Preferably, the surfactant includes at least one of sodium cocoyl glycinate, potassium cocoyl glycinate, cocamidopropyl betaine, sodium cocoylaminopropionate, potassium cocoyl hydrolyzed oat protein, disodium cocoyl glutamate, sodium methyl cocamide taurate, sodium lauroamphoacetate, lauramidopropyl betaine, sodium lauryl sulfate, sodium laureth sulfate, sodium lauroyl glutamate, disodium lauroyl glutamate, polyoxyethylene fatty alcohol ether, polyoxyethylene alkylphenol ether, alkyl glycoside, palmitic acid, myristic acid, stearic acid, and lauric acid.

[0025] Preferably, the pH regulator comprises at least one of citric acid, arginine, disodium EDTA, tromethamine, and disodium EDTA.

[0026] Preferably, the thickener includes at least one of sodium chloride, ammonium chloride, polyacrylate crosspolymer-6, carbomer, carrageenan, gellan gum, xanthan gum, microcrystalline cellulose, cellulose gum, ethyl cellulose, tara gum, guar gum, ammonium acryloyldimethyltaurate / VP copolymer, and acrylic acid (ester) copolymer.

[0027] The preparation method of the above-mentioned facial cleanser comprises the following steps:

[0028] (1) mixing a moisturizer, a portion of a pH adjuster, and a mild leave-on whitening composition with deionized water, and homogenizing at 1300 rpm for 4 minutes;

[0029] (2) Add surfactant and stir at 800 rpm for 5 min to mix;

[0030] (3) Finally, add the remaining pH adjuster to adjust the pH to 5.5-6.5, and add the thickener to adjust the viscosity to 10,000 cps. Then stop stirring and discharge the material to obtain the facial cleanser.

[0031] Compared to existing technologies, this invention offers the following advantages: through the interlayer confined adsorption of bentonite and the hydrogen bond-cation synergistic anchoring mechanism of polyquaternium-7, combined with a dual-action stabilization system of 1,3-propylene glycol and tocopheryl acetate, it achieves highly effective retention of active ingredients for whitening and brightening. Furthermore, it is stable and non-degradable in weakly acidic environments and surfactant systems, and is gentle and non-irritating, making it suitable for people with sensitive skin. Through the synergistic four-step process of bentonite adsorption and storage, polyquaternium-7 cation anchoring, 1,3-propylene glycol dissolution and stabilization, and tocopheryl acetate antioxidant, this composition achieves highly effective retention and stable delivery of oxidized resveratrol in rinse-off products, overcoming the bottleneck of "instantaneous elution of active ingredients" in traditional cleansing products. DETAILED DESCRIPTION

[0032] In order to allow those skilled in the art to understand the present invention more clearly and intuitively, the present invention will be further described below.

[0033] Example 1

[0034] The mild leave-on whitening composition of this embodiment includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, 3 parts by weight of polyquaternium-7, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of tocopheryl acetate.

[0035] During the preparation, corresponding parts by weight of resveratrol oxide and tocopherol acetate are weighed and dissolved in 1,3-propylene glycol, and corresponding parts by weight of bentonite are weighed and dispersed with 3 times the weight of deionized water, and the two are mixed evenly. Finally, corresponding parts by weight of polyquaternium-7 are added and mixed evenly to obtain a composition.

[0036] Example 2

[0037] The composition comprises 0.05 parts by weight of resveratrol oxide, 2 parts by weight of sodium bentonite, 5 parts by weight of polyquaternium-7, 1 part by weight of 1,3-propylene glycol and 1 part by weight of tocopherol acetate.

[0038] Example 3

[0039] The composition comprises 0.5 parts by weight of resveratrol oxide, 5 parts by weight of sodium bentonite, 1 part by weight of polyquaternium-7, 3 parts by weight of 1,3-propylene glycol and 0.3 parts by weight of tocopheryl acetate.

[0040] Example 4

[0041] The composition comprises 0.01 parts by weight of resveratrol oxide, 8 parts by weight of sodium bentonite, 0.1 parts by weight of polyquaternium-7, 0.1 parts by weight of 1,3-propylene glycol and 5 parts by weight of tocopherol acetate.

[0042] Example 5

[0043] The composition comprises 1 part by weight of resveratrol oxide, 1 part by weight of sodium bentonite, 10 parts by weight of polyquaternium-7, 10 parts by weight of 1,3-propylene glycol and 0.1 part by weight of tocopheryl acetate.

[0044] Example 6

[0045] The difference between Example 6 and Example 1 is that the bentonite selected is calcium-based bentonite.

[0046] Comparative Example 1

[0047] The difference between the present invention and Example 1 is that polyquaternium salt, 1,3-propylene glycol and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide and 3 parts by weight of sodium bentonite.

[0048] Comparative Example 2

[0049] The difference between this embodiment and Example 1 is that sodium bentonite, 1,3-propylene glycol and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide and 3 parts by weight of polyquaternium-7.

[0050] Comparative Example 3

[0051] The difference between the present invention and Example 1 is that sodium bentonite, polyquaternium salt and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide and 3 parts by weight of 1,3-propylene glycol.

[0052] Comparative Example 4

[0053] The difference between the present invention and Example 1 is that sodium bentonite, 1,3-propylene glycol and polyquaternium salt are not added, and the composition includes 0.1 parts by weight of resveratrol oxide and 0.5 parts by weight of tocopherol acetate.

[0054] Comparative Example 5

[0055] The difference from Example 1 is that 1,3-propylene glycol and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, and 3 parts by weight of polyquaternium-7.

[0056] Comparative Example 6

[0057] The difference between the present invention and Example 1 is that polyquaternium salt and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, and 3 parts by weight of 1,3-propylene glycol.

[0058] Comparative Example 7

[0059] The difference between the present invention and Example 1 is that 1,3-propylene glycol and polyquaternium salt are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, and 0.5 parts by weight of tocopherol acetate.

[0060] Comparative Example 8

[0061] The difference from Example 1 is that sodium bentonite and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of polyquaternium-7, and 3 parts by weight of 1,3-propylene glycol.

[0062] Comparative Example 9

[0063] The difference from Example 1 is that sodium bentonite and 1,3-propylene glycol are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of polyquaternium-7, and 0.5 parts by weight of tocopheryl acetate.

[0064] Comparative Example 10

[0065] The difference between the present invention and Example 1 is that sodium bentonite and polyquaternium salt are not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of tocopherol acetate.

[0066] Comparative Example 11

[0067] The difference from Example 1 is that sodium bentonite is not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of polyquaternium-7, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of tocopheryl acetate.

[0068] Comparative Example 12

[0069] The difference from Example 1 is that no polyquaternium salt is added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of tocopherol acetate.

[0070] Comparative Example 13

[0071] The difference from Example 1 is that 1,3-propylene glycol is not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, 3 parts by weight of polyquaternium-7, and 0.5 parts by weight of tocopheryl acetate.

[0072] Comparative Example 14

[0073] The difference from Example 1 is that tocopherol acetate is not added, and the composition includes 0.1 parts by weight of resveratrol oxide, 3 parts by weight of sodium bentonite, 3 parts by weight of polyquaternium-7, and 3 parts by weight of 1,3-propylene glycol.

[0074] Comparative Example 15

[0075] The difference between the present invention and Example 1 is that sodium bentonite, 1,3-propylene glycol, polyquaternium salt and tocopheryl acetate are not added, and the composition includes 0.1 parts by weight of resveratrol oxide.

[0076] Comparative Example 16

[0077] The difference between the embodiment 1 and the embodiment 1 is that the component contents are different. The composition includes 0.001 parts by weight of resveratrol oxide, 10 parts by weight of sodium bentonite, 0.01 parts by weight of polyquaternium-7, 0.01 parts by weight of 1,3-propylene glycol, and 10 parts by weight of tocopheryl acetate.

[0078] Comparative Example 17

[0079] The difference between the embodiment 1 and the embodiment 1 is that the component contents are different. The composition includes 5 parts by weight of resveratrol oxide, 0.1 parts by weight of sodium bentonite, 20 parts by weight of polyquaternium-7, 20 parts by weight of 1,3-propylene glycol, and 0.01 parts by weight of tocopheryl acetate.

[0080] The composition and dosage of each embodiment and comparative example are shown in Table 1.

[0081] Table 1

[0082]

[0083] Application of the above mild leave-on whitening composition

[0084] Based on the above composition, the present invention provides a facial cleanser comprising the following raw materials in weight percentage: 10%-20% of a mild leave-on whitening composition, 1%-10% of a moisturizer, 10%-30% of a surfactant, 0.01%-0.3% of a pH regulator, 0.01%-0.3% of a thickener, and the balance being deionized water.

[0085] Preferably, the moisturizing agent includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butylene glycol, 1,3-propylene glycol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine, allantoin, sodium polyacrylate, and hydrogenated lecithin.

[0086] Preferably, the surfactant includes at least one of sodium cocoyl glycinate, potassium cocoyl glycinate, cocamidopropyl betaine, sodium cocoylaminopropionate, potassium cocoyl hydrolyzed oat protein, disodium cocoyl glutamate, sodium methyl cocamide taurate, sodium lauroamphoacetate, lauramidopropyl betaine, sodium lauryl sulfate, sodium laureth sulfate, sodium lauroyl glutamate, disodium lauroyl glutamate, polyoxyethylene fatty alcohol ether, polyoxyethylene alkylphenol ether, alkyl glycoside, palmitic acid, myristic acid, stearic acid, and lauric acid.

[0087] Preferably, the pH regulator comprises at least one of citric acid, arginine, disodium EDTA, tromethamine, and disodium EDTA.

[0088] Preferably, the thickener includes at least one of sodium chloride, ammonium chloride, polyacrylate crosspolymer-6, carbomer, carrageenan, gellan gum, xanthan gum, microcrystalline cellulose, cellulose gum, ethyl cellulose, tara gum, guar gum, ammonium acryloyldimethyltaurate / VP copolymer, and acrylic acid (ester) copolymer.

[0089] The application examples of the present invention and the comparative application examples respectively provide a facial cleanser, the components (mass percentage) of the facial cleanser are shown in Table 2; wherein, the mild leave-on whitening compositions used in Application Examples 1-6 are respectively the mild leave-on whitening compositions prepared in Examples 1-6, and the mild leave-on whitening compositions used in Application Examples 7-8 are respectively the mild leave-on whitening compositions prepared in Example 1; the mild leave-on whitening compositions used in Comparative Application Examples 1-17 are respectively the compositions prepared in Comparative Examples 1-17; a blank application example is also provided, the only difference between the blank application example and Application Example 1 being that the mild leave-on whitening composition is not added;

[0090] Table 2

[0091]

[0092]

[0093] The preparation method of each of the above-mentioned facial cleansers comprises the following steps:

[0094] (1) Glycerin, disodium EDTA, and a mild leave-on whitening composition (omitted in the blank application example because this component is not present) were mixed with deionized water and homogenized at 1300 rpm for 4 minutes to obtain a preformed phase A;

[0095] (2) Add three surfactants to the prefabricated phase A in sequence, stir at 800 rpm for 5 min, and mix;

[0096] (3) Finally, add the remaining pH adjuster (citric acid) to adjust the pH to 5.5-6.5, and add the thickener (sodium chloride) to adjust the viscosity to 10,000 cps. Then stop stirring and discharge the material to obtain the facial cleanser.

[0097] Effect Experiment

[0098] 1. Stability test of oxidized resveratrol in the composition

[0099] Detection Principle: Facial cleanser provides a weak acid + surfactant environment for oxidized resveratrol. In this environment, oxidized resveratrol becomes extremely unstable, resulting in degradation. Once degraded, oxidized resveratrol cannot be detected by HPLC. This experiment uses HPLC to measure the amount of oxidized resveratrol in facial cleanser to demonstrate the improved stability of oxidized resveratrol.

[0100] Stability test: The theoretical value of the oxidized resveratrol content of the facial cleansers prepared in Application Examples 1-6 and Comparative Application Examples 1-17 is recorded as M0 = oxidized resveratrol addition amount / total weight of facial cleanser. After the facial cleanser is prepared, it is allowed to stand at room temperature in the dark for 24 hours. Then, 1g of the facial cleanser prepared in the application example and the comparative application example is accurately weighed, dissolved in 10mL of methanol, ultrasonically extracted for 10min, filtered through a 0.22μm filter membrane, and the oxidized resveratrol content is determined by high performance liquid chromatography. A standard solution with a gradient concentration (1μg / mL, 5μg / mL, 10μg / mL, 20μg / mL, 50μg / mL, 100μg / mL) is prepared using an oxidized resveratrol standard (purchased from Source Leaf Bio, B21467), and a standard curve is drawn. According to the standard curve formula, combined with the peak area of oxidized resveratrol detected in each application example, the oxidized resveratrol content M1 in each sample is calculated. The chromatographic column used was a C18 column (100 mm × 2.1 mm, 3 μM), the mobile phase was 60% methanol, the flow rate was 0.5 mL / min, and the sample volume was 10 μL. The retention rate of oxidized resveratrol was then calculated as: oxidized resveratrol retention rate = M1 / M0 × 100%. The results are shown in Table 3.

[0101] Table 3

[0102] Case Retention rate of oxidized resveratrol (%) Application Example 1 99.2 Application Example 2 96.5 Application Example 3 92.6 Application Example 4 81.1 Application Example 5 70.5 Application Example 6 98.9 Application Example 7 98.9 Application Example 8 99.0 Application range 70～100 Comparative Application Example 1 6.0 Comparative Application Example 2 13.3 Comparative Application Example 3 7.2 Comparative Application Example 4 19.2 Comparative Application Example 5 18.0 Comparative Application Example 6 11.4 Comparative Application Example 7 23.8 Comparative Application Example 8 19.0 Comparative Application Example 9 31.2 Comparative Application Example 10 26.0 Comparative Application Example 11 37.2 Comparative Application Example 12 29.0 Comparative Application Example 13 35.9 Comparative Application Example 14 23.5 Comparative Application Example 15 1.7 Comparative Application Example 16 22.9 Comparative Application Example 17 15.3 Comparative application range 1～40

[0103] The results of the application examples and comparative application examples shown in Table 3 show that the combination of bentonite, polyquaternium-7, 1,3-propylene glycol, and tocopheryl acetate significantly improves the stability of resveratrol oxide in facial cleansers. Application Example 1 and Comparative Application Examples 1-15 show that the effects of the present application cannot be achieved without one or more of these components. Application Example 1 and Comparative Application Examples 16-17 show that the effects of the present application cannot be achieved when the mass percentages of the components in Comparative Application Examples 16-17 are outside the ranges given in the present application.

[0104] 2. Skin retention test

[0105] This experiment investigates the skin retention efficacy of oxidized resveratrol in the application examples and comparative application examples, specifically including the following steps:

[0106] Experimental method: 14 healthy volunteers were recruited, 7 males and 7 females, aged 18-45 years old, with no skin damage on the inner forearms. Three 3×3 cm marks were made on the forearms of the volunteers. 2Test area, each arm tested 3 groups of samples, each group of samples were randomly tested on the arm test area of 3 volunteers, the specific test method is: evenly apply 0.2g of the facial cleanser prepared by application example 1-8 and comparative application example 1-17 on the test area, then massage for 60 seconds to simulate washing the face, then rinse with 37℃ warm water for 10 seconds, and pat dry with sterile gauze. After washing, immediately use skin tape Lightly press the marked area (pressure 500g, time 10s), peel off the residue on the skin surface, repeat 3 times, store the tape in a centrifuge tube and freeze in the dark. Add 1mL of methanol to the centrifuge tube containing the tape, ultrasonically extract for 30min, filter through a 0.22μm filter membrane, and use high-performance liquid chromatography to determine the content of oxidized resveratrol M2. The test method is the same as the high-performance liquid chromatography detection method in the stability experiment of oxidized resveratrol in the composition in effect experiment 1. The retention rate of oxidized resveratrol is then calculated, oxidized resveratrol retention rate = M2 / M0×100%. The results are shown in Table 4 below.

[0107] Table 4

[0108]

[0109]

[0110] The results of the application examples and comparative application examples shown in Table 4 show that the combination of bentonite, polyquaternium-7, 1,3-propylene glycol, and tocopheryl acetate significantly improves the skin retention efficacy of resveratrol oxide. Application Example 1 and Comparative Application Examples 1-15 show that the effects of the present application cannot be achieved without one or more of these components. Application Example 1 and Comparative Application Examples 16-17 show that the effects of the present application cannot be achieved when the mass percentages of the components in Comparative Application Examples 16-17 are outside the ranges given in the present application.

[0111] 3. Human efficacy test to explore the safety and whitening effect of the composition

[0112] Experimental Methods: 126 Asian adult test subjects aged 18-60 with dull facial skin and self-conscious skin sensitivity were randomly divided into 21 groups of 6 people each. The volunteers used the samples (facial cleansers prepared in Application Examples 1, Application Examples 7-8, Comparative Application Examples 1-17, and the blank application example) on their entire faces once a day, morning and evening, rubbing for 1 minute each time before rinsing with warm water. Volunteers were prohibited from using other whitening products during the test period. Data were collected on Day 0 and Day 28 of use.

[0113] After the visit, the subjects cleansed their faces with a non-irritating cleanser and sat quietly in an air-conditioned room with a constant temperature and humidity (21±1°C, 50±10%) for 30 minutes. The redness a* value of the cheeks was measured using a CK skin color test probe CL400, and the skin color ITA° value of the cheeks was measured using a spectrophotometer CM-26d.

[0114] The skin safety of the sample is represented by the improvement of the a* value, and the whitening ability is represented by the improvement of the ITA° value. The formula is as follows:

[0115] a* value improvement rate = (T0-T28) / T0*100%; ITA° value improvement rate = (T0-T28) / T0*100%; the results are shown in Table 5.

[0116] Table 5

[0117]

[0118]

[0119] In the table, negative values indicate excessive cleansing leading to redness and slight irritation of the skin.

[0120] The results shown in Table 5 indicate that the facial cleansers of Application Examples 1, 7, and 8 are highly safe and have excellent whitening properties, demonstrating the safety of the compositions. Furthermore, the compositions in these application examples, due to their synergistic effect on the retention of oxidized resveratrol, retain sufficient oxidized resveratrol content in the facial cleansers, thereby significantly improving the whitening effect of the facial cleansers compared to the comparative application examples. In the comparative application examples, the retention of oxidized resveratrol by the compositions was significantly reduced, directly impacting the whitening effect of the facial cleansers.

[0121] The above description of the embodiments is intended to facilitate understanding and application of the present invention by those skilled in the art. It will be apparent that those skilled in the art can readily make various modifications to these embodiments and apply the general principles described herein to other embodiments without requiring inventive effort. Therefore, the present invention is not limited to the embodiments described herein, and improvements and modifications made by those skilled in the art based on the disclosure of the present invention should fall within the scope of protection of the present invention.

Claims

1. A mild leave-on whitening composition, characterized in that: The composition comprises the following components in parts by weight: 0.01-1 parts by weight of resveratrol oxide, 1-8 parts by weight of bentonite, 0.1-10 parts by weight of polyquaternium-7, 0.1-10 parts by weight of 1,3-propylene glycol, and 0.1-5 parts by weight of tocopheryl acetate.

2. A mild leave-on whitening composition, characterized in that: The invention comprises the following components in parts by weight: 0.05-0.5 parts of resveratrol oxide, 2-5 parts by weight of bentonite, 1-5 parts by weight of polyquaternium-7, 1-5 parts by weight of 1,3-propylene glycol and 0.3-1 part by weight of tocopherol acetate.

3. A mild leave-on whitening composition, characterized in that: The invention comprises the following components in parts by weight: 0.1 parts of resveratrol oxide, 3 parts by weight of bentonite, 3 parts by weight of polyquaternium-7, 3 parts by weight of 1,3-propylene glycol, and 0.5 parts by weight of tocopheryl acetate.

4. A mild leave-on whitening composition according to any one of claims 1 to 3, characterized in that: The bentonite is at least one of sodium bentonite, calcium bentonite and organic bentonite.

5. The method for preparing a mild leave-on whitening composition according to any one of claims 1 to 3, wherein: The steps include: dissolving resveratrol oxide and tocopheryl acetate in 1,3-propylene glycol; Disperse bentonite with 3 to 5 parts by weight of deionized water; Mix the above two evenly, finally add polyquaternium-7, and continue mixing evenly to obtain the product.

6. Use of the mild leave-on whitening composition according to any one of claims 1 to 3 in whitening products.

7. A facial cleanser, characterized in that: The invention comprises the following raw materials in weight percentage: 10%-20% of a mild leave-on whitening composition according to any one of claims 1 to 3, 1%-10% of a moisturizer, 10%-30% of a surfactant, 0.01%-0.3% of a pH regulator, 0.01%-0.3% of a thickener, and the balance is deionized water.

8. A facial cleanser according to claim 7, characterized in that: The moisturizing agent includes at least one of glycerin, D-panthenol, vitamin B5, 1,3-butylene glycol, 1,3-propylene glycol, sodium hyaluronate, tremella polysaccharide, trehalose, betaine, allantoin, sodium polyacrylate, and hydrogenated lecithin.

9. The facial cleanser according to claim 7, characterized in that: The surfactant includes at least one of sodium cocoyl glycinate, potassium cocoyl glycinate, cocamidopropyl betaine, sodium cocoylaminopropionate, potassium cocoyl hydrolyzed oat protein, disodium cocoyl glutamate, sodium methyl cocamide taurate, sodium lauroamphoacetate, lauramidopropyl betaine, sodium lauryl sulfate, sodium laureth sulfate, sodium lauroyl glutamate, disodium lauroyl glutamate, polyoxyethylene fatty alcohol ether, polyoxyethylene alkylphenol ether, alkyl glucoside, palmitic acid, myristic acid, stearic acid, and lauric acid.

10. The facial cleanser according to claim 7, characterized in that: The thickener includes at least one of sodium chloride, ammonium chloride, polyacrylate crosspolymer-6, carbomer, carrageenan, gellan gum, xanthan gum, microcrystalline cellulose, cellulose gum, ethyl cellulose, tara gum, guar gum, ammonium acryloyldimethyltaurate / VP copolymer, and acrylic acid (ester) copolymer.

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