Anti-hair loss composition and anti-hair loss wash supplies

Abstract

The invention relates to the field of wash supplies, and particularly discloses an anti-hair-loss composition and an anti-hair-loss wash supplies, the anti-hair-loss composition is composed of a cacumen biotae extract, a mulberry leaf extract, a cortex mori extract, a fructus viticis extract, a black mulberry extract, a polygonum multiflorum extract, a ligusticum wallichii extract and cedar wood oil according to a weight ratio of (2-4): (1-3): (0.2-1): (0.2-1): (0.1-0.5): (0.2-0.5): (0.05-0.5): (0.01-0.25); the anti-hair loss wash supplies comprise the anti-hair loss composition disclosed by the invention. The shampoo can mildly maintain the scalp environment, and tests prove that the shampoo can effectively promote hair growth and prevent alopecia.

Description

Technical Field

[0001] The present invention relates to the field of toiletries, in particular to an anti-hair loss composition and an anti-hair loss toiletries. Background Art

[0002] Hair plays a crucial role in personal appearance. Healthy, beautiful, and lustrous hair often enhances a person's image, but premature hair loss can negatively impact one's mental health and quality of life. Both men and women may experience early hair loss, characterized by gradual thinning, sparse hair, and fine hair, often accompanied by increased oil production on the scalp.

[0003] Currently, early-stage hair loss is mainly treated through hair growth drugs or hair transplantation. Among them, hair growth drug treatment mainly improves the condition through oral administration of finasteride, spironolactone and other drugs, and at the same time uses some topical ointments to solve hair loss caused by certain reasons to a certain extent, but it does not fundamentally maintain the scalp environment and provide a good foundation for hair growth; hair transplantation treatment mainly improves hair loss through hair follicle transplantation, but it is expensive and may have certain risks of hair follicle damage and bacterial infection.

[0004] Therefore, it is very necessary to study a kind of washing and protecting product that improves scalp environment and is convenient for maintaining hair. Summary of the Invention

[0005] The present invention provides an anti-hair loss composition and an anti-hair loss washing and care product, which can effectively improve the scalp environment, promote hair growth and prevent hair loss.

[0006] To achieve the above object, the technical solution of the present invention is:

[0007] Disclosed is an anti-hair loss composition, which comprises Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia fruit extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2-4:1-3:0.2-1:0.2-1:0.1-0.5:0.2-0.5:0.05-0.5:0.01-0.25.

[0008] Preferably, the anti-hair loss composition is composed of Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2:1:0.5:0.4:0.3:0.3:0.14:0.07.

[0009] Preferably, the Platycladus orientalis leaf extract is an ethanol extract; and / or the mulberry leaf extract is an ethanol extract; and / or the Morus alba bark extract is an ethanol extract; and / or the Vitex rotundifolia fruit extract is an ethanol extract; and / or the black mulberry extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract; and / or the Ligusticum chuanxiong extract is an ethanol extract.

[0010] Preferably, the weight of the Platycladus orientalis leaf extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the mulberry leaf extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Morus alba bark extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Vitex rotundifolia extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the black mulberry extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Polygonum multiflorum extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Ligusticum chuanxiong extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug.

[0011] Preferably, the preparation method of the Platycladus orientalis leaf extract and / or the mulberry leaf extract and / or the Morus alba bark extract and / or the Vitex rotundifolia fruit extract and / or the Morus nigra fruit extract and / or the Polygonum multiflorum extract and / or the Ligusticum chuanxiong extract comprises the following steps:

[0012] (1) Weighing the original medicinal material, crushing it, adding 2 to 5 times its weight of 5 to 10 wt% sodium bicarbonate solution and soaking it for at least 30 minutes to obtain a medicinal material soaking solution;

[0013] (2) adding 80% to 90% vol. ethanol solution in an amount of 2 to 5 times the weight of the medicinal material soaking solution to the medicinal material soaking solution to obtain a mixed medicinal material extract material, then adding 0.05 to 0.1 wt% of 2,6-di-tert-butyl-p-methylphenol by weight of the medicinal material mixed extract material, heating and refluxing for 2 to 3 hours, and separating the medicinal material alcohol extract; repeating the above steps 1 to 3 times, and combining the medicinal material alcohol extracts;

[0014] (3) The combined medicinal material alcohol extract is concentrated to 1 / 2 to 1 times the weight of the original medicinal material to obtain the corresponding medicinal material extract.

[0015] Of course, the extraction method of the above extract is not limited to the preferred method described above, and other methods such as supercritical extraction and ultrasonic extraction can also be used for extraction.

[0016] The present invention also provides an anti-hair loss cleaning product, comprising the anti-hair loss composition described above.

[0017] Preferably, the anti-hair loss composition is added to the toiletries as the only anti-hair loss active ingredient, and the weight percentage of the anti-hair loss composition added to the toiletries is 0.1% to 5.0%.

[0018] Preferably, the toiletries are shampoo, conditioner, hair mask or shampoo soap.

[0019] In the anti-hair loss composition of the present invention, each component has the following functions:

[0020] Platycladus orientalis (L.) Franco's dried branches and leaves are bitter and astringent in taste and cold in nature. They have the effects of cooling blood and stopping bleeding, resolving phlegm and relieving cough, and promoting hair growth and blackening hair.

[0021] Mulberry leaves are the dried leaves of Morus alba L., a plant of the Moraceae family. They are bitter and cold in nature. They have the effects of dispersing wind-heat, clearing the lungs, and improving eyesight.

[0022] Morus alba bark is the dried root bark of the dicotyledonous plant Morus alba L. after removing the cork. It tastes sweet and is cold in nature. It has the effects of clearing the lungs and relieving asthma, promoting water circulation and reducing swelling, and promoting blood circulation and removing blood stasis.

[0023] Vitex trifolia L.var.simplicifolia Cham. or Vitex trifolia L., a plant of the Verbenaceae family, is the dried mature fruit. It tastes spicy and bitter, is slightly cold in nature, and has the effects of dispersing wind-heat and clearing the head.

[0024] Black mulberry tastes sweet, flat and slightly cold in nature. It has the effects of nourishing blood and yin, promoting fluid production and quenching thirst, and moistening the intestines.

[0025] Polygonum multiflorum, the dried tuberous root of Polygonum multiflorum Thunb. of the Polygonaceae family, is pungent in taste and slightly warm in nature. It has the effects of nourishing essence and blood, detoxifying and stopping malaria, and moistening the intestines and promoting bowel movements.

[0026] Chuanxiong is the dried rhizome of Ligusticum chuanxiong Hort. of the Apiaceae family. It is pungent in taste and warm in nature. It has the effects of promoting blood circulation, promoting qi, dispelling wind and relieving pain.

[0027] Cedarwood oil, an essential oil extracted from the bark, trunk or wood of Cedrus by distillation, has astringent, antibacterial and sedative effects.

[0028] The present invention combines Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia fruit extract, black mulberry extract, Polygonum multiflorum extract, and Ligusticum chuanxiong extract for use in anti-hair loss shampoo and conditioner products. The product is natural and non-irritating, can gently maintain the scalp environment, and has been proven by experiments to be able to effectively promote hair growth and prevent hair loss. DETAILED DESCRIPTION

[0029] To make the objectives, technical solutions, and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the embodiments described are part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] An anti-hair loss composition, comprising: Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2-4:1-3:0.2-1:0.2-1:0.1-0.5:0.2-0.5:0.05-0.5:0.01-0.25 (e.g., 2:1:0.2:0.2:0.1:0.2:0 .05:0.01, 4:3:1:1:0.5:0.5:0.5:0.25, 2:1:0.5:0.4:0.3:0.3:0.14:0.07, 2:1:0.3:0.2:0.3:0.2:0.14:0.07, 3:1.5:1:0.5:0.3:0.3:0.2:0.1 or 3:2:1:0.5:0.4:0.4:0.2:0.07).

[0031] Preferably, the anti-hair loss composition is composed of Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2:1:0.5:0.4:0.3:0.3:0.14:0.07.

[0032] Preferably, the Platycladus orientalis leaf extract is an ethanol extract; and / or the mulberry leaf extract is an ethanol extract; and / or the Morus alba bark extract is an ethanol extract; and / or the Vitex rotundifolia fruit extract is an ethanol extract; and / or the black mulberry extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract; and / or the Ligusticum chuanxiong extract is an ethanol extract.

[0033] Preferably, the weight of the Platycladus orientalis leaf extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5, or 1) of the weight of the original drug; and / or the weight of the mulberry leaf extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5, or 1) of the weight of the original drug; and / or the weight of the Morus alba bark extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5, or 1) of the weight of the original drug; and / or the weight of the Vitex rotundifolia extract is calculated by concentrating its weight to and / or the weight of the black mulberry extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Polygonum multiflorum extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5 or 1) of the weight of the original drug; and / or the weight of the Chuanxiong extract is calculated by concentrating its weight to 1 / 2 to 1 (e.g., 1 / 2, 1 / 2 / 3, 4 / 5 or 1) of the weight of the original drug.

[0034] Preferably, the Platycladus orientalis leaf extract is an ethanol extract; and / or the mulberry leaf extract is an ethanol extract; and / or the Morus alba bark extract is an ethanol extract; and / or the Vitex rotundifolia fruit extract is an ethanol extract; and / or the black mulberry extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract; and / or the Ligusticum chuanxiong extract is an ethanol extract. The preparation method comprises the following steps:

[0035] (1) Weighing the original medicinal material, crushing it, adding 2 to 5 times its weight of 5 to 10 wt% sodium bicarbonate solution and soaking it for at least 30 minutes to obtain a medicinal material soaking solution;

[0036] (2) adding 80% to 90% vol. ethanol solution in an amount of 2 to 5 times the weight of the medicinal material soaking solution to the medicinal material soaking solution to obtain a mixed medicinal material extract material, then adding 0.05 to 0.1 wt% of 2,6-di-tert-butyl-p-methylphenol by weight of the medicinal material mixed extract material, heating and refluxing for 2 to 3 hours, and separating the medicinal material alcohol extract; repeating the above steps 1 to 3 times, and combining the medicinal material alcohol extracts;

[0037] (3) The combined medicinal material alcohol extract is concentrated to 1 / 2 to 1 times the weight of the original medicinal material to obtain the corresponding medicinal material extract.

[0038] Of course, the extraction method of the above extract is not limited to the preferred method described above, and other methods such as supercritical extraction and ultrasonic extraction can also be used for extraction.

[0039] The present invention also provides an anti-hair loss cleaning product, comprising the anti-hair loss composition described above.

[0040] Preferably, the anti-hair loss composition is added to the toiletries as the only anti-hair loss active ingredient, and the weight percentage of the anti-hair loss composition added to the toiletries is 0.1%-5.0% (e.g., 0.1%, 0.3%, 0.5%, 1%, 3% or 5%).

[0041] Preferably, the toiletries are shampoo, conditioner, hair mask or shampoo soap.

[0042] The present invention will be further described below by way of examples, but the protection scope of the present invention is not limited to these examples.

[0043] In this embodiment, the preparation method of Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia fruit extract, black mulberry extract, Polygonum multiflorum extract, and Ligusticum chuanxiong extract is as follows: (1) respectively taking the corresponding original medicinal materials and crushing them, adding 2 times the weight of 10wt% sodium bicarbonate solution and soaking for 1 hour to obtain medicinal material soaking liquid; (2) adding 85%vol. ethanol solution 5 times the weight of the medicinal material soaking liquid to the medicinal material soaking liquid to obtain a mixed medicinal material extraction material, and then adding 0.05wt% of 2,6-di-tert-butyl-p-methylphenol by weight of the medicinal material mixed extraction material, heating and refluxing at 80°C for 2 hours to separate the medicinal material alcohol extract; repeating the above steps once, and combining the medicinal material alcohol extracts; (3) taking the combined medicinal material alcohol extract, concentrating to 1 / 2 times the weight of the original medicinal material, and obtaining the corresponding medicinal material extract.

[0044] The anti-hair loss composition is prepared by mixing Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia fruit extract, black mulberry extract, Polygonum multiflorum extract and Ligusticum chuanxiong extract in a certain proportion to obtain the anti-hair loss composition.

[0045] 1. Screening of anti-hair loss compositions

[0046] Animal experiment: Animals used in the animal experiment of the anti-hair loss shampoo and conditioner: 8 Wistar rats, half male and half female.

[0047] Experimental drugs: 5% minoxidil; 5% aqueous solutions of composition #1, composition #2, composition #3, composition #4, and composition #5. The composition compositions are shown in Table 1.

[0048] Table 1 Composition of 1#-5# compositions

[0049]

[0050] Test Method: Rats were numbered 1-16. The backs of the rats were evenly divided into four areas (2 cm x 2 cm) ABCD, with the spine as the midline, from head to tail. Half of each area was divided into two sections. After removing all hair, the drug was applied according to the arrangement in Table 2, with a dosage of 0.2 ml. A blank was smeared with distilled water. After 21 days, a tuft of new hair was plucked from the treated area. Ten longer hairs were visually selected and measured with a vernier caliper. The average value was used as the hair growth length value for that area. The hair in the treated area was then carefully removed, collected, and weighed to obtain the hair growth weight value.

[0051] Table 2 List of drugs administered to mice in the screening test of the anti-hair loss composition

[0052]

[0053] The test results are shown in Table 3:

[0054] Table 3 Anti-hair loss test effect of mixed component test

[0055] area Rat hair length (mm) Gross weight of growing rats (mg) 5% minoxidil (mice 1-8) 14.09 49.03 Composition #1 (mice 1-8) 13.92 48.88 Composition 2# (mice 1-8) 12.67 45.93 Composition #5 (mice 1-8) 16.09 53.17 Blank (mice 1-8) 12.01 44.59 5% minoxidil (mice 9-16) 14.37 49.55 Composition #3 (mice 9-16) 13.55 47.79 Composition 4# (mice 9-16) 12.31 45.51 Composition #5 (mice 9-16) 16.38 53.49 Blank (mice 9-16) 12.16 45.26

[0056] The experimental results show that the 5# composition has the effect of promoting hair growth.

[0057] 2. Anti-hair loss efficacy test of anti-hair loss compositions with different ratios

[0058] Animal experiment: Animals used in the animal experiment of the anti-hair loss shampoo and conditioner: 8 Wistar rats, half male and half female.

[0059] Experimental drugs: 5% minoxidil; 5% aqueous solutions of 1# anti-hair loss composition, 2# anti-hair loss composition, and 3# anti-hair loss composition, wherein the composition of 3# anti-hair loss composition is the same as that of 5# composition, and the compositions of 1# anti-hair loss composition and 2# anti-hair loss composition are shown in Table 4.

[0060] Table 4 Anti-shedding composition composition

[0061]

[0062] Test Method: Rats were numbered 1-8. The backs of the rats were evenly divided into four areas (2 cm x 2 cm) ABCD, with the spine as the midline, from head to tail. Half of each area was left and half was right. After removing all hair, the drug was applied according to the arrangement in Table 5, with a dosage of 0.2 ml. A blank was smeared with distilled water. After 21 days, a tuft of new hair was plucked from the treated area. Ten longer hairs were visually selected and measured with a vernier caliper. The average value was calculated as the hair growth length for that area. The hair in the treated area was then carefully removed, collected, and weighed to obtain the hair growth weight.

[0063] Table 5 List of drugs applied to mice in the screening test of anti-hair loss compositions with different ratios

[0064]

[0065] The test results are shown in Table 6:

[0066] Table 6 Anti-hair loss test effect of mixed components

[0067] area Rat hair length (mm) Gross weight of growing rats (mg) 5% minoxidil 14.23 49.35 1# Anti-shedding composition 12.33 45.57 2# Anti-shedding composition 14.67 49.58 3# Anti-shedding composition 16.49 53.61 blank 12.19 45.12

[0068] The experimental results show that the shampoo and conditioner of the present invention has the effect of promoting hair growth, and the anti-hair loss effect of the 3# anti-hair loss composition is the best.

[0069] 3. Shampoo Anti-Hair Loss Test

[0070] 3.1 Preparation of anti-hair loss shampoo: apply the above 3# anti-hair loss composition to shampoo.

[0071] Examples 1 to 3 are the raw materials and weight percentages of the anti-hair loss shampoo, as shown in Table 7:

[0072] Table 7 Anti-hair loss shampoo formula

[0073]

[0074] 3.2 Anti-hair loss test of anti-hair loss shampoo

[0075] Sixty volunteers with an average hair loss of more than 100 hairs per day were selected and divided into three groups, with half male and half female. The male subjects washed their hair daily, while the female subjects washed their hair every two days. They combed their hair twice a day, collected and counted the fallen hairs, and the average value was calculated. The test results are shown in Table 8:

[0076] Table 8 Average value of hair loss

[0077]

[0078] The experimental results show that the shampoo and conditioner containing the 3# anti-hair loss composition has an anti-hair loss effect, and the anti-hair loss effect is more significant with the increase of usage time and content.

Claims

1. An anti-hair loss composition, characterized in that The anti-hair loss composition comprises Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2-4:1-3:0.2-1:0.2-1:0.1-0.5:0.2-0.5:0.05-0.5:0.01-0.

25.

2. The anti-hair loss composition according to claim 1, characterized in that The anti-hair loss composition is composed of Platycladus orientalis leaf extract, mulberry leaf extract, Morus alba bark extract, Vitex rotundifolia extract, black mulberry extract, Polygonum multiflorum extract, Ligusticum chuanxiong extract, and cedarwood oil in a weight ratio of 2:1:0.5:0.4:0.3:0.3:0.14:0.

07.

3. The anti-hair loss composition according to claim 1, characterized in that The Platycladus orientalis leaf extract is an ethanol extract; and / or the mulberry leaf extract is an ethanol extract; and / or the Morus alba bark extract is an ethanol extract; and / or the Vitex rotundifolia fruit extract is an ethanol extract; and / or the black mulberry extract is an ethanol extract; and / or the Polygonum multiflorum extract is an ethanol extract; and / or the Ligusticum chuanxiong extract is an ethanol extract.

4. The anti-hair loss composition according to claim 1, characterized in that The weight of the Platycladus orientalis leaf extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the mulberry leaf extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Morus alba bark extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Vitex rotundifolia extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the black mulberry extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Polygonum multiflorum extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug; and / or the weight of the Ligusticum chuanxiong extract is calculated by concentrating its weight to 1 / 2 to 1 of the weight of the original drug.

5. The anti-hair loss composition according to claim 4, characterized in that The preparation method of the Platycladus orientalis leaf extract and / or the mulberry leaf extract and / or the Morus alba bark extract and / or the Vitex rotundifolia fruit extract and / or the Morus nigra fruit extract and / or the Polygonum multiflorum extract and / or the Ligusticum chuanxiong extract comprises the following steps: (1) Weigh the original medicinal material, crush it, add 2 to 5 times its weight of 5 to 10 wt% sodium bicarbonate solution and soak it for at least 30 minutes to obtain the medicinal material soaking solution; (2) adding 80% to 90% vol. ethanol solution in an amount of 2 to 5 times the weight of the medicinal material soaking solution to the medicinal material soaking solution to obtain a mixed medicinal material extraction material, and then adding 0.05 to 0.1 wt% of 2,6-di-tert-butyl-p-methylphenol by weight of the medicinal material mixed extraction material, heating and refluxing for 2 to 3 hours, and separating the medicinal material alcohol extract; repeating the above steps 1 to 3 times, and combining the medicinal material alcohol extracts; (3) Take the combined medicinal material alcohol extract and concentrate it to 1 / 2 to 1 times the weight of the original medicinal material to obtain the corresponding medicinal material extract.

6. An anti-hair loss cleaning product, characterized in that: The invention comprises the anti-hair loss composition according to any one of claims 1 to 5.

7. The anti-hair loss toiletries according to claim 6, characterized in that: The anti-hair loss composition is added to the toiletries as the only anti-hair loss active ingredient, and the weight percentage of the anti-hair loss composition added to the toiletries is 0.1% to 5.0%.

8. The anti-hair loss toiletries according to claim 6, characterized in that: The washing and care products are shampoo, hair conditioner, hair mask or shampoo soap.

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