Medicinal and edible traditional Chinese medicine composition for invigorating spleen and tonifying kidney and preparation method of medicinal and edible traditional Chinese medicine composition

Abstract

The invention discloses a medicinal and edible traditional Chinese medicine composition for tonifying spleen and kidney and a preparation method thereof, and belongs to the technical field of biology and new medicine. The medicinal and edible traditional Chinese medicine composition for invigorating spleen and tonifying kidney comprises the following raw materials in parts by weight: 40-50 parts of American ginseng, 30-40 parts of lily, 10-20 parts of semen ziziphi spinosae, 5-10 parts of fructus gardeniae, 5-10 parts of poria cocos, 5-10 parts of platycodon grandiflorum, 5-10 parts of angelica sinensis and 20-30 parts of microcapsules, and the raw materials of the microcapsules comprise mulberries, rhizoma polygonati, lucid ganoderma and Chinese wolfberry fruits. In addition, the invention also provides a preparation method of the medicinal and edible traditional Chinese medicine composition, which comprises the following steps: mixing American ginseng, lily, spina date seed, gardenia, poria cocos, platycodon grandiflorum, angelica sinensis and water, boiling and extracting twice to obtain a second extract; and mixing the second extract with the microcapsules to obtain the medicinal and edible traditional Chinese medicine composition. The composition provided by the invention can effectively invigorate the spleen and tonify the kidney under the cooperation of all the components.

Description

Technical Field

[0001] The present invention relates to the field of biology and new medicine technology, and in particular to a Chinese medicinal composition with medicinal and edible properties for invigorating the spleen and kidneys and a preparation method thereof. Background Art

[0002] In modern society, with the increasingly rapid pace of life, people are constantly under high-intensity work pressure, irregular work and rest schedules, and unhealthy eating habits. This lifestyle leads to a gradual imbalance in bodily functions, and sub-health conditions such as Qi and blood deficiency, spleen and stomach weakness, and kidney deficiency are becoming increasingly common. According to relevant survey data, over 60% of urban office workers experience varying degrees of Qi and blood deficiency symptoms, manifesting as pale complexion, dizziness, fatigue, palpitations, and insomnia. Approximately 75% experience poor spleen and stomach function, often experiencing loss of appetite, indigestion, abdominal distension, and pain. Kidney deficiency symptoms are becoming increasingly common in both men and women, seriously impacting people's quality of life and physical health.

[0003] Therefore, relevant drugs are continued to solve the above problems. With the development of social economy and the change of health concepts, people's demand for safe and effective traditional Chinese medicine health services is increasing. Ginseng and Astragalus Paste is an ointment prepared and developed under the guidance of classical Chinese medicine theory and according to national standard technology. It has the effects of strengthening the spleen and dampness, replenishing qi and benefiting the kidney, promoting blood circulation and removing blood stasis, promoting muscle growth and strengthening bones, etc. It is usually used to regulate the body, enhance physical fitness or treat certain diseases. It is mainly composed of Chinese herbal medicines such as ginseng and astragalus, and is commonly found in Chinese medicine stores or pharmacies.

[0004] Paste is a common Chinese medicine preparation. It extracts the active ingredients of Chinese medicine and reduces impurities, which is beneficial to the human body's absorption. However, the active ingredients are easily inactivated and can be easily destroyed by gastric juice when consumed, thereby reducing or losing their corresponding functions.

[0005] Therefore, the need to develop a Chinese medicine composition with significant spleen and kidney invigorating effects is an urgent problem to be solved in the current field of Chinese medicine. Summary of the Invention

[0006] The purpose of the present invention is to overcome the above technical deficiencies, provide a Chinese medicine composition with medicinal and edible properties for invigorating the spleen and kidneys and a preparation method thereof, and solve the technical problem that the prior art lacks a Chinese medicine composition with significant invigorating the spleen and kidneys efficacy.

[0007] In order to achieve the above technical objectives, the technical solution of the present invention provides a Chinese medicine composition for strengthening the spleen and kidneys, which is characterized in that the raw materials, calculated by weight, include: 40-50 parts of American ginseng, 30-40 parts of lily, 10-20 parts of spinach seeds, 5-10 parts of gardenia, 5-10 parts of poria, 5-10 parts of platycodon, 5-10 parts of angelica and 20-30 parts of microcapsules, and the raw materials of the microcapsules include mulberry, polygonatum, ganoderma lucidum and wolfberry.

[0008] In some embodiments, the raw materials of the microcapsules are calculated by weight and include 30-40 parts of mulberry, 10-20 parts of polygonatum, 20-30 parts of ganoderma lucidum and 20-30 parts of wolfberry.

[0009] In some embodiments, the raw materials of the microcapsules further include 3-5 parts of soybean powder.

[0010] In some embodiments, 10-20 parts of isomaltooligosaccharide solution are further included.

[0011] In some embodiments, 0.02-0.05 parts of potassium sorbate are also included.

[0012] In some embodiments, the microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1-1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1-1.2 to obtain a first extract; dissolving maltodextrin in water to obtain a maltodextrin solution, then mixing it with the first extract, then emulsifying, and then freeze-drying to obtain the microcapsules.

[0013] In some embodiments, the maltodextrin is dissolved in water in a mass ratio of 1:(8-10) to water; and / or the mass ratio of the maltodextrin solution to the first extract is 10:(5-7).

[0014] In some embodiments, the microcapsules are prepared by the following steps: mixing a maltodextrin solution with soybean powder, then mixing with a first extract, then emulsifying, and then freeze-drying to obtain the microcapsules.

[0015] In addition, the present invention also provides a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0016] Mix American ginseng, lily, jujube seeds, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a second extract;

[0017] The second extract is mixed with the microcapsules to obtain the Chinese medicinal composition having both medicinal and edible properties.

[0018] In some embodiments, the method further includes mixing the second extract with a gum arabic solution, followed by emulsification, and then continuing to mix with the microcapsules, and then freeze-drying to obtain the Chinese medicine composition with both medicinal and edible properties.

[0019] Compared with the existing technology, the beneficial effects of the present invention include: American ginseng is used in the largest amount, mainly replenishing spleen qi and nourishing stomach yin, which is the core of strengthening the spleen; Poria helps American ginseng to strengthen the spleen and eliminate dampness, Angelica replenishes blood and nourishes blood, and Polygonatum replenishes qi and yin, and the three enhance the biochemical function of spleen and stomach qi and blood; Gardenia clears heat and prevents greasiness, lily and jujube kernel calm the mind and aid digestion, Platycodon regulates qi and prevents stagnation of tonics; wrapping ingredients such as mulberry, yellow elf ganoderma and wolfberry may delay the release and protect effective ingredients (such as antioxidants), while reducing irritation to the gastrointestinal tract and improving absorption efficiency, and thus with the cooperation of various components, it can effectively strengthen the spleen and kidney. DETAILED DESCRIPTION

[0020] The "range" disclosed in this application is defined in the form of a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundaries of a particular range. The range defined in this way can be inclusive or exclusive of the end values, and can be arbitrarily combined, i.e., any lower limit can be combined with any upper limit to form a range. For example, if a range of 60 to 120 and 80 to 110 is listed for a particular parameter, it is understood that a range of 60 to 110 and 80 to 120 is also expected. In addition, if the minimum range values listed are 1 and 2, and if the maximum range values listed are 3, 4, and 5, then the following ranges can all be expected: 1 to 3, 1 to 4, 1 to 5, 2 to 3, 2 to 4, and 2 to 5. In this application, unless otherwise specified, the numerical range "a to b" represents an abbreviation of any real number combination between a and b, wherein a and b are both real numbers. For example, a numerical range of "0-5" indicates that all real numbers between "0-5" are listed herein, and "0-5" is simply an abbreviation for these numerical combinations. Furthermore, stating that a parameter is an integer ≥ 2 is equivalent to disclosing that the parameter is, for example, an integer of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0021] Unless otherwise specified, the terms "include" and "comprising" used in this application may be open-ended or closed-ended. For example, "include" and "comprising" may mean that other components not listed may also be included or that only the listed components are included.

[0022] Unless otherwise specified, the term "or" is used in this application to be inclusive. For example, the phrase "A or B" means "A, B, or both A and B." More specifically, the condition "A or B" is satisfied if any of the following conditions are met: A is true (or exists) and B is false (or does not exist); A is false (or does not exist) and B is true (or exists); or both A and B are true (or exist).

[0023] This specific embodiment provides a Chinese medicinal composition for strengthening the spleen and kidneys, which is both medicinal and edible. The raw materials, calculated by weight, include: 40-50 parts of American ginseng, 30-40 parts of lily, 10-20 parts of spinach seeds, 5-10 parts of gardenia, 5-10 parts of poria, 5-10 parts of platycodon, 5-10 parts of angelica and 20-30 parts of microcapsules. The raw materials of the microcapsules include mulberry, polygonatum, ganoderma lucidum and wolfberry.

[0024] In some embodiments, the raw materials of the microcapsules are calculated by weight and include 30-40 parts of mulberry, 10-20 parts of polygonatum, 20-30 parts of ganoderma lucidum and 20-30 parts of wolfberry.

[0025] In some embodiments, the microcapsule ingredients also include 3-5 parts of soybean powder. Soybean powder has a certain adsorption capacity, which can absorb other ingredients in the microcapsule and help them be slowly released. Furthermore, the nutrients in soybean powder are easily absorbed and utilized by the spleen and stomach, further strengthening the physiological functions of the spleen and kidneys, achieving the effect of "treating both the symptoms and the root cause."

[0026] In some embodiments, 10-20 parts of isomaltooligosaccharide solution are further included.

[0027] In some embodiments, 0.02-0.05 parts of potassium sorbate are also included.

[0028] In some embodiments, the microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1-1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1-1.2 to obtain a first extract; dissolving maltodextrin in water at 50-60°C, then cooling to obtain a maltodextrin solution, then adding the maltodextrin solution to the first extract while stirring, then emulsifying with a high shear emulsifier (10,000-15,000 rpm) for 10-15 minutes, and then freeze-drying to obtain the microcapsules.

[0029] In some embodiments, the maltodextrin is dissolved in water in a mass ratio of 1:(8-10) to water; and / or the mass ratio of the maltodextrin solution to the first extract is 10:(5-7).

[0030] In some embodiments, the microcapsules are prepared by the following steps: mixing a maltodextrin solution with soybean powder, then mixing with a first extract, then emulsifying, and then freeze-drying to obtain the microcapsules.

[0031] In addition, this specific embodiment also proposes a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0032] Mix American ginseng, lily, jujube seeds, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a second extract;

[0033] The second extract is mixed with the microcapsules to obtain the Chinese medicinal composition having both medicinal and edible properties.

[0034] In some embodiments, the second extract is further mixed with a gum arabic solution, followed by emulsification, and then further mixed with the microcapsules, followed by freeze-drying to obtain the edible and medicinal Chinese medicine composition. The gum arabic solution is obtained by mixing gum arabic with 50-60°C water in a mass ratio of 1:(6-8), followed by cooling. The mass ratio of the gum arabic solution to the second extract is 1:(0.6-0.8). By utilizing the emulsifying and stabilizing properties of gum arabic and the cryogenic protection of freeze-drying, the extract is converted into a solid, retaining the spleen-tonifying and kidney-benefiting activity of the Chinese medicine composition while improving the dosage form's stability, ease of administration, and bioavailability, thereby further enhancing the spleen-tonifying and kidney-benefiting effects.

[0035] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0036] The pharmacology of each component is as follows:

[0037] American ginseng: Sweet, slightly bitter, and cooling; it enters the lung, heart, kidney, and spleen meridians, tonifying qi and nourishing yin, clearing heat and promoting fluid production. Its qi-tonifying effect directly enhances the spleen and stomach's function of transportation and transformation, improving symptoms such as loss of appetite and fatigue caused by spleen deficiency and qi deficiency. Its yin-nourishing properties prevent excessive qi tonification from damaging yin, making it suitable for those with both spleen and yin deficiency.

[0038] Poria: Sweet, mild, and neutral in nature; it enters the Heart, Lung, Spleen, and Kidney meridians. It invigorates the spleen and eliminates dampness, calming the mind and tranquilizing the spirit. By promoting diuresis and dispelling dampness, it alleviates dampness and turbidity in the spleen and stomach, restoring the spleen and stomach's function of ascending lucidity and descending turbidity, making it a commonly used herb for strengthening the spleen.

[0039] Polygonatum: Nature and flavor: sweet, neutral; enters the spleen, lung, and kidney meridians; tonifies qi and nourishes yin, strengthens the spleen and moistens the lungs. It can both tonify spleen qi and nourish spleen yin, suitable for those with spleen and stomach qi and yin deficiency, and has a mild medicinal property, nourishing without stagnation.

[0040] Angelica sinensis: Nature and flavor: sweet, pungent, warm; enters the liver, heart, and spleen meridians; nourishes blood, promotes blood circulation, regulates menstruation, and relieves pain. Entering the spleen meridian, it can strengthen the spleen and stomach Qi and blood production by replenishing blood, indirectly promoting spleen and stomach function (the spleen is the source of Qi and blood production).

[0041] Mulberry: Nature and flavor: sweet, sour, cold; enters the heart, liver, and kidney meridians; nourishes yin and blood, promotes fluid production and relieves dryness. It specifically enters the kidney meridian, nourishing kidney yin and improving symptoms such as soreness of the waist and knees, dizziness, and tinnitus caused by kidney yin deficiency.

[0042] Lycium barbarum: Nature and flavor: sweet, neutral; enters the liver and kidney meridians; nourishes the liver and kidneys, improves essence and eyesight. It is a classic herbal ingredient for tonifying the kidneys and replenishing essence, enhancing kidney essence reserves and improving kidney deficiency and essence deficiency.

[0043] Polygonatum: In addition to strengthening the spleen, its property of entering the kidney meridian can replenish kidney qi and nourish kidney yin, achieving "double nourishment of the spleen and kidneys."

[0044] American ginseng: enters the kidney meridian, nourishes yin and clears heat, can help improve kidney yin deficiency, and synergizes with mulberry and wolfberry to enhance the kidney-benefiting effect.

[0045] Lily: Nourishes the lungs and clears the heart, soothing the mind. By nourishing the heart's yin and calming the mind, it improves the effects of emotional imbalance on the spleen and stomach (Traditional Chinese Medicine believes that the heart and spleen are interconnected, and a restless mind can lead to spleen deficiency).

[0046] Ziziphus jujuba seeds: nourish the heart, soothe the mind, and reduce sweating. Similarly, soothing the mind can help the spleen and stomach digest food, and is especially suitable for those with spleen deficiency and insomnia.

[0047] Gardenia: It clears away heat and dampness, and helps dispel heat and dampness. It helps prevent Qi-tonifying and Yin-nourishing herbs from being too nourishing and hot, and balances the medicinal properties to avoid "tonifying while retaining pathogenic factors."

[0048] Platycodon grandiflorum: It clears the lungs, relieves sore throats, and eliminates phlegm and pus. As a guiding herb, it guides the upward movement of other herbs, while also assisting the spleen and stomach in digestion and metabolism by clearing the lungs and regulating qi (the lungs and spleen are like mother and child; clearing the lungs helps strengthen the spleen).

[0049] In the present invention, references to “some embodiments”, “this embodiment”, examples, etc. describe a subset of all possible embodiments, but it can be understood that “some embodiments” may be the same subset or different subsets of all possible embodiments, and may be combined with each other without conflict.

[0050] If similar descriptions of "first / second" appear in the application documents, the following explanation is added. In the following description, the terms "first\second\third" are merely used to distinguish similar objects and do not represent a specific order for the objects. It can be understood that "first\second\third" can be interchanged with the specific order or sequence where permitted, so that the embodiments described herein can be implemented in an order other than that described herein.

[0051] In this embodiment, the term "and / or" is merely a description of the association relationship between associated objects, indicating that three relationships may exist. For example, object A and / or object B may represent three situations: object A exists alone, object A and object B exist at the same time, and object B exists alone.

[0052] Example 1

[0053] This embodiment provides a Chinese medicine composition for strengthening the spleen and kidneys, which is both medicinal and edible. The raw materials, calculated by weight, include: 45 parts of American ginseng, 35 parts of lily, 15 parts of spinach seeds, 5-10 parts of gardenia, 8 parts of poria, 5 parts of platycodon, 10 parts of angelica, 25 parts of microcapsules, 10 parts of oligomaltodextrose solution and 0.02 parts of potassium sorbate; the raw materials of the microcapsules, calculated by weight, include 40 parts of mulberry, 15 parts of polygonatum, 25 parts of ganoderma lucidum and 25 parts of wolfberry.

[0054] The microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1 to obtain a first extract; dissolving maltodextrin in water at 60°C, cooling to obtain a maltodextrin solution, adding the maltodextrin solution to the first extract while stirring, emulsifying for 15 minutes using a high-shear emulsifier (10,000-15,000 rpm), and freeze-drying to obtain the microcapsules; dissolving maltodextrin in water at a mass ratio of 1:9; and the mass ratio of the maltodextrin solution to the first extract is 10:5.

[0055] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0056] Mix American ginseng, lily, spinach seed, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1 to obtain a second extract;

[0057] The second extract, isomaltooligosaccharide solution, potassium sorbate and the microcapsules are mixed to obtain the Chinese medicine composition having both medicinal and edible properties.

[0058] Example 2

[0059] This embodiment provides a Chinese medicine composition for strengthening the spleen and kidneys, which is both medicinal and edible. The raw materials, calculated by weight, include: 40 parts of American ginseng, 40 parts of lily, 20 parts of spinach seeds, 5 parts of gardenia, 10 parts of poria, 5 parts of platycodon, 8 parts of angelica, 20 parts of microcapsules, 15 parts of oligomaltodextrose solution and 0.05 parts of potassium sorbate; the raw materials of the microcapsules, calculated by weight, include 35 parts of mulberry, 10 parts of polygonatum, 20 parts of ganoderma lucidum and 30 parts of wolfberry.

[0060] The microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice for 1 hour each time, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.2 to obtain a first extract; dissolving maltodextrin in 50°C water, cooling to obtain a maltodextrin solution, adding the maltodextrin solution to the first extract while stirring, emulsifying for 10 minutes using a high-shear emulsifier (10,000-15,000 rpm), and freeze-drying to obtain the microcapsules; dissolving maltodextrin in water at a mass ratio of 1:10; and the mass ratio of the maltodextrin solution to the first extract is 10:7.

[0061] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0062] Mix American ginseng, lily, spinach seed, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1 hour, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.2 to obtain the second extract;

[0063] The second extract, isomaltooligosaccharide solution, potassium sorbate and the microcapsules are mixed to obtain the Chinese medicine composition having both medicinal and edible properties.

[0064] Example 3

[0065] This embodiment provides a Chinese medicine composition for strengthening the spleen and kidneys, which is both medicinal and edible. The raw materials, calculated by weight, include: 50 parts of American ginseng, 30 parts of lily, 10 parts of spinach seeds, 10 parts of gardenia, 8 parts of poria, 8 parts of platycodon, 10 parts of angelica, 30 parts of microcapsules, 20 parts of isomaltooligosaccharide solution and 0.02 parts of potassium sorbate; the raw materials of the microcapsules, calculated by weight, include 30 parts of mulberry, 20 parts of polygonatum, 30 parts of ganoderma lucidum and 20 parts of wolfberry.

[0066] The microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1 to obtain a first extract; dissolving maltodextrin in water at 55°C, cooling to obtain a maltodextrin solution, adding the maltodextrin solution to the first extract while stirring, emulsifying for 12 minutes using a high-shear emulsifier (10,000-15,000 rpm), and freeze-drying to obtain the microcapsules; dissolving maltodextrin in water at a mass ratio of 1:8; and the mass ratio of the maltodextrin solution to the first extract is 10:7.

[0067] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0068] Mix American ginseng, lily, spinach seed, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1 hour, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.2 to obtain the second extract;

[0069] The second extract, isomaltooligosaccharide solution, potassium sorbate and the microcapsules are mixed to obtain the Chinese medicine composition having both medicinal and edible properties.

[0070] Example 4

[0071] The difference between the Chinese medicinal composition for strengthening the spleen and kidney and edible medicinal properties of this embodiment and that of Example 1 is that the raw materials of the microcapsules further include 4 parts of soybean powder.

[0072] The microcapsules were prepared by the following steps: mixing the maltodextrin solution of Example 1 with soybean powder, then adding the maltodextrin solution to the first extract while stirring, then emulsifying with a high shear emulsifier (10,000-15,000 rpm) for 15 minutes, and then freeze-drying to obtain the microcapsules.

[0073] The preparation method of the above-mentioned Chinese medicine composition with medicinal and edible properties in this embodiment is the same as that in Example 1.

[0074] Example 5

[0075] The difference between this embodiment and embodiment 1 is that the present embodiment does not contain isomaltooligosaccharide solution and potassium sorbate.

[0076] This embodiment provides a Chinese medicine composition for strengthening the spleen and kidneys, which is both medicinal and edible. The raw materials, calculated by weight, include: 45 parts of American ginseng, 35 parts of lily, 15 parts of spinach seeds, 5-10 parts of gardenia, 8 parts of poria, 5 parts of platycodon, 10 parts of angelica, and 25 parts of microcapsules; the raw materials of the microcapsules, calculated by weight, include 40 parts of mulberry, 15 parts of polygonatum, 25 parts of ganoderma lucidum, and 25 parts of wolfberry.

[0077] The microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1 to obtain a first extract; dissolving maltodextrin in water at 60°C, cooling to obtain a maltodextrin solution, adding the maltodextrin solution to the first extract while stirring, emulsifying for 15 minutes using a high-shear emulsifier (10,000-15,000 rpm), and freeze-drying to obtain the microcapsules; dissolving maltodextrin in water at a mass ratio of 1:9; and the mass ratio of the maltodextrin solution to the first extract is 10:5.

[0078] This embodiment also provides a method for preparing the above-mentioned Chinese medicine composition having both medicinal and edible properties, comprising the following steps:

[0079] Mix American ginseng, lily, spinach seed, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1 to obtain a second extract;

[0080] The second extract is mixed with an arabic gum solution, followed by emulsification, and then further mixed with the microcapsules, and then freeze-dried to obtain the edible and medicinal Chinese medicine composition; the arabic gum solution is obtained by mixing arabic gum and 60°C water in a mass ratio of 1:7 and then cooling; the mass ratio of the arabic gum solution to the second extract is 1:0.7.

[0081] Example 6

[0082] The difference between this embodiment and embodiment 5 is that the microcapsules further include 4 parts of soybean powder.

[0083] The microcapsules were prepared by the following steps: mixing the maltodextrin solution of Example 1 with soybean powder, adding the maltodextrin solution to the first extract while stirring, emulsifying with a high shear emulsifier (10,000-15,000 rpm) for 15 minutes, and freeze-drying to obtain the microcapsules.

[0084] The other raw material components and preparation method of the Chinese medicine composition with medicinal and edible properties are the same as those in Example 5.

[0085] Related test 1

[0086] To establish a spleen and stomach deficiency model, 80 mice were fasted for 24 hours, but not water, to maintain a relatively empty gastrointestinal tract. They were then gavaged with a 50% ethanol solution for five consecutive days, with each mouse receiving 1 ml twice daily. Ethanol, a strong irritant, can damage the gastric mucosa, disrupting the normal physiological function of the gastrointestinal tract and causing symptoms of spleen and stomach deficiency, such as loss of appetite and indigestion. This successfully established a spleen and stomach deficiency model.

[0087] In the Chinese medicine composition group, the Chinese medicine compositions of Examples 1-4 of the present invention were administered in the form of pastes to mice at a dosage of 1.0 mL / kg, once daily for 14 consecutive days. The drugs of Examples 5-6 were administered in the form of solid microcapsules to mice at a dosage of 1 g / kg, once daily for 14 consecutive days.

[0088] Model control group: 1.0 mL / kg of normal saline was administered orally once a day for 14 consecutive days. The model control group consisted of mice that had undergone modeling and were not given any medication.

[0089] Normal control group: 1.0 mL / kg of normal saline was administered orally once a day for 14 consecutive days. No modeling was performed on the mice in the normal control group.

[0090] Positive drug control group: According to the experimental model, the corresponding positive drug was given by gavage. For the spleen and stomach deficiency model, 1.0 mL / kg of Sijunzi Decoction was given once a day for 14 consecutive days.

[0091] There were 10 mice in each group, and the mice had free access to feed and drinking water.

[0092] Gastrointestinal function indicators (used to detect spleen and stomach weakness) Observe and record the weight changes and food intake of mice, and test pepsin activity and. The specific test data results are shown in Table 1 below.

[0093] Table 1

[0094]

[0095] As can be seen from Table 1, the pharmaceutical compositions of Examples 1-3 increased the body weight and pepsin activity of mice, while the pharmaceutical compositions of Examples 4-6 increased the body weight and pepsin activity of mice to a greater extent, especially the pharmaceutical composition of Example 6 which increased the body weight and pepsin activity most significantly.

[0096] Related test 2

[0097] Establishing a kidney deficiency model: Mice were subcutaneously injected with hydrocortisone at a dose of 20 mg / kg for seven consecutive days. Long-term use of hydrocortisone can inhibit the function of the hypothalamic-pituitary-adrenal axis, leading to hormonal imbalances in mice and symptoms associated with kidney deficiency, such as weakness in the waist and knees and decreased immunity.

[0098] In the Chinese medicine composition group, the Chinese medicine compositions of Examples 1-4 of the present invention were administered in the form of pastes to mice at a dosage of 1.0 mL / kg, once daily for 14 consecutive days. The drugs of Examples 5-6 were administered in the form of solid microcapsules to mice at a dosage of 1 g / kg, once daily for 14 consecutive days.

[0099] Model control group: 1.0 mL / kg of normal saline was administered orally once a day for 14 consecutive days. The model control group consisted of mice that had undergone modeling and were not given any medication.

[0100] Normal control group: 1.0 mL / kg of normal saline was administered orally once a day for 14 consecutive days. No modeling was performed on the mice in the normal control group.

[0101] Positive drug control group: mice were given 1g / kg of Liuwei Dihuang Wan according to their body weight, once a day for 14 consecutive days.

[0102] There were 10 mice in each group, and the mice had free access to feed and drinking water.

[0103] Renal function indicators (used to detect kidney deficiency): Serum creatinine (Cr) and blood urea nitrogen (BUN) levels in mice, as well as superoxide dismutase (SOD) activity in kidney tissue, were measured. The specific results are shown in Table 2 below.

[0104] Table 2

[0105]

[0106] As can be seen from Table 2, the pharmaceutical compositions of Examples 1-6 can reduce the levels of creatinine and urea nitrogen, and can also increase the SOD activity in kidney tissue. The pharmaceutical composition of Example 6 can most significantly increase the SOD activity in kidney tissue and reduce the levels of creatinine and urea nitrogen.

[0107] We selected 40 patients with spleen and stomach deficiency or kidney deficiency and divided them into two groups. After taking the composition of Example 6 of the present application, Sijunzi Decoction, or Liuwei Dihuang Pills respectively, the improvement rate reached 90% after a 14-day taking period, while the improvement rate of patients taking Sijunzi Decoction or Liuwei Dihuang Pills was only 60%.

[0108] The specific embodiments of the present invention described above do not limit the scope of protection of the present invention. Any other corresponding changes and modifications made based on the technical concept of the present invention should be included in the scope of protection of the claims of the present invention.

Claims

1. A Chinese medicinal composition for invigorating the spleen and kidneys, characterized in that: The raw materials are calculated by weight and include: 40-50 parts of American ginseng, 30-40 parts of lily, 10-20 parts of spinach seeds, 5-10 parts of gardenia, 5-10 parts of poria, 5-10 parts of platycodon, 5-10 parts of angelica and 20-30 parts of microcapsules. The raw materials of the microcapsules include mulberry, polygonatum, ganoderma lucidum and wolfberry.

2. The Chinese medicine composition of claim 1, wherein: The raw materials of the microcapsule are calculated by weight and include 30-40 parts of mulberry, 10-20 parts of polygonatum, 20-30 parts of ganoderma lucidum and 20-30 parts of wolfberry.

3. The Chinese medicine composition of claim 1 or 2, characterized in that: The raw materials of the microcapsules also include 3-5 parts of soybean powder.

4. The Chinese medicine composition of claim 1, wherein: Also includes 10-20 parts of isomaltooligosaccharide liquid.

5. The Chinese medicinal composition of claim 4, wherein: Also included is 0.02-0.05 parts of potassium sorbate.

6. The Chinese medicine composition of claim 1, wherein: The microcapsules are prepared by the following steps: mixing mulberry, polygonatum, ganoderma lucidum, wolfberry and water, boiling and extracting twice, each time for 1-1.5 hours, combining the filtrates, and concentrating under reduced pressure to a relative density of 1.1-1.2 to obtain a first extract; dissolving maltodextrin in water to obtain a maltodextrin solution, then mixing the maltodextrin solution with the first extract, emulsifying, and then freeze-drying to obtain the microcapsules.

7. The Chinese medicinal composition of claim 6, wherein: The maltodextrin is dissolved in water in a mass ratio of 1:(8-10); and / or the mass ratio of the maltodextrin solution to the first extract is 10:(5-7).

8. The Chinese medicinal composition of claim 6, wherein: The microcapsules are prepared by the following steps: mixing maltodextrin solution with soybean powder, then mixing with the first extract, then emulsifying, and then freeze-drying to obtain the microcapsules.

9. A method for preparing the edible and medicinal Chinese medicine composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: Mix American ginseng, lily, jujube seeds, gardenia, poria, platycodon, angelica and water, boil and extract twice, each time for 1-1.5 hours, combine the filtrates, and concentrate under reduced pressure to a relative density of 1.1-1.2 to obtain a second extract; The second extract is mixed with the microcapsules to obtain the Chinese medicinal composition having both medicinal and edible properties.

10. The method for preparing the edible and medicinal Chinese medicine composition according to claim 9, characterized in that: The method further comprises mixing the second extract with a gum arabic solution, emulsifying the solution, mixing the solution with the microcapsules, and freeze-drying the solution to obtain the Chinese medicine composition having both medicinal and edible properties.

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