Aerosol driver with drying function

Abstract

The invention discloses an aerosol driver with a drying function, and relates to a method for isolating and / or drying a drug delivery channel in a drug delivery instrument, the aerosol driver comprises a shell and a protective cover, the shell is internally provided with a sealing structure, and the protective cover is arranged in the shell. The sealing structure divides the interior of the shell into a containing cavity used for installing an aerosol tank and a delivery cavity used for delivering medicine, a nozzle connected with a discharging opening of a proportional valve rod on the aerosol tank is installed in the delivery cavity, and an installation opening matched with the nozzle in a sealing mode is formed in the sealing structure. The shell is further provided with a suction nozzle communicated with the delivery cavity. The protective cover is used for sealing the delivery cavity, and a drying agent is arranged in the delivery cavity or the protective cover. According to the invention, the problem of moisture can be fundamentally solved, the medicine delivery channel and the suction cavity on the suction nozzle are always kept in a dry state, and the problems caused by moisture in the air and moisture caused by expiration of a patient in the use process are completely eradicated.

Description

Technical Field

[0001] The present invention relates to a method for isolating and / or drying a drug delivery channel in a drug delivery device, and in particular to an aerosol driver with a drying function. Background Art

[0002] Metered dose inhaler (MDI) is a preparation form that delivers medication to the lungs through the respiratory tract after atomizing a medicinal liquid into uniform droplets through a drug delivery device. During the drug delivery process, the gas exhaled by the patient and the moisture in the air will moisten the residual aerosol powder inside the nozzle and valve stem, thereby causing it to adhere to the inner wall of the valve stem and the inner wall of the nozzle hole. After repeated use and long-term contact with moist air, it will cause the drug delivery channel to be narrow, and even cause blockage in severe cases. In order to solve this technical problem, a drug delivery system and related methods with drying and sealing functions are disclosed in the invention patent with application number 201880079337.2. However, the present invention has found after detailed study that its structural design is still imperfect, and the provided drug delivery system is still faced with the problem of large changes in spray morphology after long-term use, thereby affecting the uniformity of the delivered dose and effective lung deposition, reducing the clinical treatment effect.

[0003] In view of this, it is indeed necessary to propose improvements to the existing metered dose inhaler (MDI) nebulizer to solve the above-mentioned problems. Summary of the Invention

[0004] The purpose of the present invention is to provide an aerosol driver with a drying function, which can solve the moisture problem from the root, ensure that the drug delivery channel and the suction cavity of the mouthpiece are always kept dry, eliminate the above problems caused by moisture in the air and moisture caused by the patient's exhaled breath during use, avoid drug scaling on the valve stem, nozzle orifice and the inner wall of the nozzle, and maintain the stability of the atomization effect.

[0005] To achieve the purpose of the present invention, the technical solution adopted is: an aerosol driver with a drying function, comprising:

[0006] A housing having a sealing structure therein, the sealing structure dividing the interior of the housing into a receiving chamber for mounting the aerosol canister and a delivery chamber for delivering the drug, the delivery chamber containing a nozzle connected to the discharge port of the metered dose valve stem on the aerosol canister, the sealing structure having a mounting opening for sealingly engaging the nozzle; the housing also having a mouthpiece in communication with the delivery chamber;

[0007] and a protective cover, which is used to open or close the delivery cavity, and a desiccant is also provided in the delivery cavity or the protective cover.

[0008] Furthermore, a cavity is provided in the protective cover, and the desiccant is installed in the cavity.

[0009] Furthermore, the protective cover is provided with limiting ribs for pressing the desiccant.

[0010] Furthermore, an annular channel is formed between the periphery of the desiccant and the inner wall of the cavity.

[0011] Furthermore, a drying shell is installed in the delivery cavity, a desiccant is installed in the drying shell, and a side surface of the drying shell has a through hole.

[0012] Furthermore, the desiccant is in granular, powdery or block form.

[0013] Furthermore, the sealing structure includes a fixed plate fixed inside the shell and a sealing plate that can be close to or away from the fixed plate. When the protective cover is installed, the sealing plate is sealed and fits with the fixed plate, and the installation port on the sealing plate is slidingly sealed with the nozzle.

[0014] Furthermore, the sealing plate also has a fixing frame that passes through the fixing plate and extends into the delivery cavity. The protective cover and the fixing frame are jointly provided with a plug-in structure, which enables the protective cover to be installed while pulling the sealing plate and the fixing plate into fit.

[0015] Furthermore, the plug-in structure includes a pushing hole provided on the fixing frame and a pushing arm provided on the sealing plate, and a wall of the pushing hole is provided with a wedge-shaped surface that cooperates with the pushing arm.

[0016] Furthermore, the extended end of the fixing frame also has a limiting buckle A, and the delivery cavity also has a limiting buckle B for engaging with the limiting buckle A, and the limiting buckle A can slide on the limiting buckle B along the movement direction of the sealing plate.

[0017] Furthermore, the limiting buckle A is composed of two locking hooks arranged opposite to each other, and the limiting buckle B is T-shaped, and the two locking hooks in the limiting buckle A are hung on both sides of the limiting buckle B respectively.

[0018] Furthermore, a spring is installed between the fixing plate and the sealing plate.

[0019] Furthermore, a spring mounting hole is provided on the fixing plate or / and sealing plate, and the end of the spring is mounted in the spring hole.

[0020] Furthermore, the fixing plate is provided with a positioning post, and the sealing plate is provided with a sliding hole that is slidably matched with the positioning post.

[0021] Furthermore, a sealing ring is provided on the fitting surface of the sealing plate or the fitting surface of the fixing plate.

[0022] The beneficial effects of the present invention are:

[0023] 1. In the present invention, a sealing structure is provided in the outer shell to separate the delivery chamber from the receiving chamber, so that the protective cover is provided on the mouthpiece to seal the delivery chamber, and the desiccant is installed in the protective cover or the delivery chamber. When the patient is not in use, the desiccant in the delivery chamber or the protective cover can dry the entire delivery chamber. Since the valve stem and the nozzle on the aerosol can are both located in the delivery chamber, the desiccant in the protective cover or the delivery chamber can dry the valve stem and the mouthpiece on the aerosol can, solving the moisture problem from the root, ensuring that the drug delivery channel and the inner chamber of the mouthpiece are always kept dry, and eliminating the above problems caused by moisture in the air and moisture caused by the patient's exhalation during use. The driver provided by the present invention was used to investigate the use of three API drugs for 30 days. The change in the MMAD median particle size was less than 0.2μm, and the spray area of the driver at 3cm from the nozzle outlet decreased to 0.5cm 2 The spray angle of the driver at 5.3 cm and 8.3 cm from the nozzle outlet drops by less than 3°, which significantly improves the stability of the driver provided by the present invention in terms of atomization effect, spray area and spray angle.

[0024] 2. The driver provided by the present invention can effectively reduce the water vapor content in the channel, thereby reducing the potential risks brought by the accumulation of water vapor and the breeding of impurities and bacteria, providing patients with a safer and more efficient treatment experience.

[0025] 3. The driver provided by the present invention has a simpler design of structural components. While meeting the requirement of preventing scaling of the nozzle and the spray hole caused by moisture in the driver, it has fewer parts and lower costs during mass production, which can greatly reduce the production cost of the product. At the same time, since the driver components provided by the present invention are simpler and easier to assemble, the assembly efficiency can also be greatly improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings illustrate exemplary embodiments of the present invention and together with the description serve to explain the principles of the present invention. These drawings are included to provide a further understanding of the present invention and are incorporated in and constitute a part of this specification.

[0027] Figure 1 is an exploded view of the aerosol driver with drying function in Example 1;

[0028] Figure 2 is a structural diagram of the protective cover in Example 1;

[0029] Figure 3 Schematic diagram of the installation of the desiccant in Example 1;

[0030] Figure 4 is a layout diagram of the nozzles in Example 1;

[0031] Figure 5 is a layout diagram of the fixed plate in Example 1;

[0032] Figure 6 is a layout diagram of the sealing plate in Example 1;

[0033] Figure 7 is a structural diagram of the sealing plate in Example 1;

[0034] Figure 8 1 is a diagram of the engagement of the position-limiting buckle A and the position-limiting buckle B in Example 1;

[0035] Figure 9 This is a structural diagram of the desiccant installed in the protective cover in Example 1;

[0036] Figure 10 This is a schematic diagram of the aerosol driver with a drying function in Example 1 when the protective cover is not installed;

[0037] Figure 11 Schematic diagram of the protective cover of the aerosol driver with drying function in Example 1 when installed;

[0038] Figure 12 This is the CT image of the control driver before spraying provided in Control Example 1;

[0039] Figure 13 This is a CT image of the control driver provided in Control Example 1 20 days after spraying;

[0040] Figure 14 This is a CT image of the aerosol driver with drying function before spraying in Example 1;

[0041] Figure 15 This is a CT image of the aerosol driver with drying function in Example 1 after spraying for 20 days;

[0042] Figure 16 is an exploded view of the aerosol driver with drying function in Example 2;

[0043] Figure 17 is a structural diagram of the protective cover in Example 2;

[0044] Figure 18 Schematic diagram of the installation of the desiccant in Example 2;

[0045] Figure 19 is a layout diagram of the nozzles in Example 2;

[0046] Figure 20 is a layout diagram of the fixed plate in Example 2;

[0047] Figure 21is a layout diagram of the sealing plate in Example 2;

[0048] Figure 22 is a structural diagram of the sealing plate in Example 2;

[0049] Figure 23 1 is a diagram of the engagement of the position-limiting buckle A and the position-limiting buckle B in Example 2;

[0050] Figure 24 is a schematic diagram of the aerosol driver with a drying function in Example 2 when the protective cover is not installed;

[0051] Figure 25 Schematic diagram of the protective cover of the aerosol driver with drying function in Example 2 when installed;

[0052] Figure 26 This is a CT image of the aerosol driver with drying function before spraying in Example 2;

[0053] Figure 27 This is a CT image of the aerosol driver with drying function in Example 2 after 20 days of spraying;

[0054] Figure 28 is an exploded view of the control driver provided in Control Example 2;

[0055] Figure 29 It is a structural diagram of the protective cover in comparative example 2;

[0056] Figure 30 is a structural diagram of the cylindrical shell in comparative example 2;

[0057] Figure 31 is the layout diagram of the positioning ribs in the cylindrical shell in comparative example 2;

[0058] Figure 32 is a structural diagram of the nozzle in comparative example 2;

[0059] Figure 33 Schematic diagram of the installation of the desiccant in comparative example 2;

[0060] Figure 34 This is a schematic diagram of the structure in which the desiccant is installed in the protective cover in Comparative Example 2;

[0061] Figure 35 is a schematic diagram of the protective cover of the control driver provided in Comparative Example 2 when it is installed;

[0062] Figure 36 This is the CT image of the control driver before spraying provided in Control Example 2;

[0063] Figure 37 This is a CT image of the control driver provided in Control Example 2 20 days after spraying.

[0064] Markings and corresponding parts names in the accompanying drawings:

[0065] 1. Shell, 2. Protective cover, 3. Desiccant, 4. Cylindrical structure; 5. Drying shell, 6. Annular channel;

[0066] 100, accommodating chamber, 101, delivery chamber, 102, fixing plate, 103, sealing plate, 104, mounting opening, 106, fixing frame, 107, pushing hole, 108, wedge-shaped surface, 109, limiting buckle A, 120, limiting buckle B, 121, spring, 122, spring mounting hole, 123, positioning column, 124, sliding hole, 125, sealing ring, 126, nozzle, 127, suction nozzle, 128, avoidance opening, 129, opening;

[0067] 200, cavity, 201, push arm;

[0068] 400, limiting reinforcement;

[0069] 500, through hole;

[0070] 100', circular boss;

[0071] 200', semicircular buckle, 201', plug interface, 202', cylindrical shell, 204', positioning rib, 205', circular step surface, 206', convex ridge, 207', cross rib, 208', annular soft rubber pad, 209', circular boss. DETAILED DESCRIPTION

[0072] The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It will be understood that the specific embodiments described herein are intended only to explain the relevant content and are not intended to limit the present invention. It should also be noted that, for ease of description, only portions relevant to the present invention are shown in the accompanying drawings.

[0073] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments of the present invention can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0074] Example 1

[0075] like Figures 1 to 11As shown, the present invention provides an aerosol driver with a drying function, comprising a housing 1 and a protective cover 2. The housing 1 is L-shaped as a whole and includes a sealing structure located at a corner within the housing 1. The sealing structure divides the interior of the housing 1 into a receiving chamber 100 and a delivery chamber 101. The receiving chamber 100 is used to mount the aerosol canister, and the delivery chamber 101 is used to deliver the sprayed drug into the patient's oral cavity. The aerosol canister described in this embodiment has its own metered dose valve, and the delivery chamber 101 includes a nozzle 126. The nozzle 126 engages with the discharge port of the metered dose valve stem on the aerosol canister, and the nozzle orifice of the nozzle 126 communicates with the delivery chamber 101. Since the aerosol can is installed in the accommodating chamber 100 and the nozzle 126 is installed in the delivery chamber 101, in order to ensure that the valve stem of the metered dose valve on the aerosol can can be inserted into the nozzle 126, the sealing structure also has a mounting opening 104 that seals with the nozzle 126. This not only ensures the subsequent normal pressing of the aerosol can, but also ensures the airtight isolation of the accommodating chamber 100 and the delivery chamber 101.

[0076] In this embodiment, the installation height of the sealing structure within the housing 1 is lower than the upper end surface of the nozzle 126. That is, the end of the nozzle 126 closest to the accommodating chamber 100 extends through the installation opening 104 on the sealing structure and into the accommodating chamber 100. Of course, the installation height of the sealing structure within the housing 1 in this embodiment can also be higher than the nozzle 126. In this case, the installation opening 104 on the sealing structure needs to be in sealing engagement with the valve stem of the metered-dose valve on the aerosol can.

[0077] The housing 1 also has a suction nozzle 127, which is an integral structure with the housing 1. The interior of the suction nozzle 127 is connected to the interior of the delivery chamber 101, ensuring that the patient's mouth can be placed on the suction nozzle 127 when the aerosol driver is in use, and ensuring that the medicine sprayed through the nozzle 126 can enter the patient's oral cavity through the suction nozzle 127.

[0078] The aerosol driver further comprises a protective cover 2 covering the suction nozzle 127 . After the protective cover 2 is covered on the suction nozzle 127 , the delivery chamber 101 is closed, thereby isolating the delivery chamber 101 from the outside.

[0079] In order to ensure the dryness in the delivery chamber 101, Figure 3 As shown, a desiccant 3 is provided in the protective cover 2. When the protective cover 2 is placed on the suction nozzle 127, the desiccant 3 in the protective cover 2 can effectively dry the delivery chamber 101. Since the nozzle 126 is located in the delivery chamber 101 and the valve stem of the metered-dose valve on the aerosol can is inserted in the nozzle 126, the desiccant 3 can also dry the nozzle 126 and the valve stem of the metered-dose valve on the aerosol can, which can solve the moisture problem from the root and ensure that the drug delivery channel and the suction cavity of the suction nozzle 127 are always kept dry.

[0080] In this embodiment, in order to facilitate the arrangement of the desiccant 3, as shown in FIG. Figure 2 As shown, the protective cover 2 also has a cavity 200. Specifically, a cylindrical structure 4 is set in the center of the protective cover 2. The interior of the cylindrical structure 4 is the cavity 200. The desiccant 3 is installed in the cavity 200 to ensure that the protective cover 2 can be normally installed and disassembled without causing damage to the desiccant 3.

[0081] In order to prevent the desiccant 3 from falling out of the cavity 200, Figure 3 、 Figure 9 As shown, the protective cover 2 is further provided with a limiting rib 400 that can press the desiccant 3 into the cavity 200. In this embodiment, the limiting rib 400 is cross-shaped, and the limiting rib 400 is surrounded by a cannula that is plugged into the cylindrical structure 4. When the desiccant 3 is placed in the cavity 200, the cannula is inserted into the cavity 200, so that the limiting rib 400 presses the desiccant 3.

[0082] In this embodiment, the limiting rib 400 may also be in a grid shape, a cross shape, etc., and the limiting rib 400 may not rely on the plug-in cooperation between the insert tube and the cylindrical structure 4 to press the desiccant 3, but directly snap the limiting rib 400 around the cylindrical structure 4, or snap the limiting rib 400 around the circumferential surface of the protective cover 2, etc. That is, while ensuring that the limiting rib 400 can press the desiccant 3 in the cavity 200, the fixation of the limiting rib 400 can be adjusted according to demand.

[0083] In addition, in this embodiment, the desiccant 3 is compressed by the limiting ribs 400, which not only ensures the compression and fixation of the desiccant 3, but also ensures that the desiccant 3 can contact the delivery chamber 101 as much as possible, so that the drying effect of the delivery chamber 101 is guaranteed.

[0084] In order to make the desiccant 3 contact with the delivery cavity 101 as much as possible, Figure 3 As shown, after the desiccant 3 is installed in the cavity 200, there is a certain distance between the outer periphery of the desiccant 3 and the inner wall of the cavity 200, so that an annular channel 6 is formed between the outer periphery of the desiccant 3 and the inner wall of the cavity 200. After the desiccant 3 is placed in the cavity 200, the four sides of the desiccant 3 and the side of the desiccant 3 pressed by the limiting rib 400 can be fully released, so that the drying effect of the delivery cavity 101 is better.

[0085] When the side of the desiccant 3 pressed by the limiting ribs 400 is sufficient to dry the delivery chamber 101, there is no need to reserve a gap between the outer periphery of the desiccant 3 and the inner wall of the cavity 200. In addition, when the protective cover 2 is deep enough and the side of the desiccant 3 pressed by the limiting ribs 400 is sufficient to dry the delivery chamber 101, there is no need to set up a separate cavity 200 in the protective cover 2. In this case, the desiccant 3 can be directly set at the bottom of the protective cover 2 and then pressed by the limiting ribs 400. The inner wall of the protective cover 2 acts as the cylindrical structure 4, and the limiting ribs 400 can be directly buckled or snapped with the inner wall of the protective cover 2, which can achieve both the installation of the desiccant 3 and the pressing of the desiccant 3.

[0086] In this embodiment, the desiccant 3 can be in granular, powdered or block form. When the desiccant 3 is in granular or powdered form, in order to prevent the desiccant 3 from being scattered at will, the desiccant 3 can be first packaged in a net bag or a breathable packaging bag, and then the packaged desiccant 3 can be placed in the cavity 200.

[0087] In order to isolate the receiving cavity 100 and the delivery cavity 101, as Figure 5 、 Figure 6 、 Figure 7 、 Figure 10 、 Figure 11 As shown, the sealing structure includes a fixed plate 102 integral with the housing 1, and a sealing plate 103 located above the fixed plate 102. The sealing plate 103 is located on the side of the fixed plate 102 close to the accommodating chamber 100, and the sealing plate 103 can move closer to or further away from the sealing plate 103. When the sealing plate 103 is away from the fixed plate 102, the accommodating chamber 100 and the delivery chamber 101 have a certain degree of connectivity. When the sealing plate 103 is in contact with the fixed plate 102, the accommodating chamber 100 and the delivery chamber 101 are completely isolated. To ensure the dryness of the delivery chamber 101, when the protective cover 2 is placed on the suction nozzle 127, the sealing plate 103 is in a sealed contact with the fixed plate 102.

[0088] In this embodiment, since the position of the fixing plate 102 in the housing 1 remains fixed and the height of the nozzle 126 is higher than the height of the entire sealing structure, the fixing plate 102 and the nozzle 126 can be designed as one piece during design. At this time, the mounting port 104 on the fixing plate 102 and the outer wall of the nozzle 126 are seamlessly connected. Since the sealing plate 103 needs to be close to or away from the fixed plate 102, when the sealing plate 103 is designed, the mounting opening 104 on the sealing plate 103 is in sliding and sealing cooperation with the outer wall of the nozzle 126. When the mounting opening 104 on the sealing plate 103 and the outer wall of the nozzle 126 are in sliding and sealing cooperation, when the sealing plate 103 is at the farthest distance from the fixed plate 102, the nozzle 126 and the sealing plate 103 can be completely separated, or the nozzle 126 can still be inserted in the mounting opening 104 on the sealing plate 103; when the sealing plate 103 is at the farthest distance from the fixed plate 102, the nozzle 126 and the sealing plate 103 are completely separated. In this case, in order to ensure that the nozzle 126 can be accurately inserted into the mounting opening 104 on the sealing plate 103 when the sealing plate 103 is close to the fixed plate 102, the end of the nozzle 126 close to the sealing plate 103 can be chamfered so that the outer wall of the nozzle 126 close to the end of the sealing plate 103 is conical.

[0089] When the fixed plate 102 cooperates with the sealing plate 103 to achieve a sealed separation between the accommodating chamber 100 and the delivery chamber 101, it should be noted that when the fixed plate 102 and the sealing plate 103 are in contact, they can cover the entire cross-section of the housing 1. When this condition is met, when the fixed plate 102 is seamlessly connected to the inner wall of the housing 1 on all sides, a certain gap can be retained around the sealing plate 103 and the inner wall of the housing 1. However, when there is a certain gap between the fixed plate 102 and the inner wall of the housing 1 on all sides, the position on the sealing plate 103 corresponding to the gap must maintain a sliding and sealing fit with the inner wall of the housing 1. Of course, regardless of whether there is a gap at the junction of the fixed plate 102 and the inner wall of the housing 1, the sealing plate 103 can maintain a sliding and sealing fit with the inner wall of the housing 1 on all sides.

[0090] In order to ensure that the fixing plate 102 and the sealing plate 103 fit together when the protective cover 2 is covered, so that the delivery chamber 101 remains airtight, the sealing plate 103 is also provided with a fixing frame 106 extending toward the delivery chamber 101 on the side close to the fixing plate 102, and the fixing plate 102 is also provided with an avoidance opening 128 for the fixing frame 106 to pass through; at the same time, the protective cover 2 and the fixing frame 106 are jointly provided with a plug-in structure. When the protective cover 2 is covered on the suction nozzle 127, the protective cover 2 and the fixing frame 106 are plugged into each other through the plug-in structure, and the fixing frame 106 is pulled while plugging into each other, thereby driving the sealing plate 103 to move toward the fixing plate 102, so that the sealing plate 103 and the fixing plate 102 are sealed and fitted.

[0091] Furthermore, Figure 2 、 Figure 7As shown, the plug-in structure includes a pushing hole 107 provided on the fixed frame 106 and a pushing arm 201 provided on the sealing plate 103. The hole wall of the pushing hole 107 has a wedge-shaped surface 108. The height of the wedge-shaped surface 108 close to one end of the pushing arm 201 is lower than the height of the wedge-shaped surface 108 away from one end of the pushing arm 201. When the protective cover 2 is covered on the suction nozzle 127, the pushing arm 201 is inserted into the pushing hole 107. As the protective cover 2 continues to be covered, the pushing arm 201 continues to be inserted. While the pushing arm 201 is inserted, it pushes the fixed frame 106 toward the delivery chamber 101, thereby pulling the sealing plate 103 closer to the fixed plate 102. When the protective cover 2 is completely covered, the plug-in end of the pushing arm 201 is completely inserted into the pushing hole 107, and the sealing plate 103 is sealed and fitted with the fixed plate 102.

[0092] To ensure smoother movement of the sealing plate 103, two fixing frames 106 may be provided on the sealing plate 103, symmetrically arranged along the center of the sealing plate 103 and located on either side of the nozzle 126. Furthermore, two push arms 201 may be provided on the protective cover 2, corresponding to the two fixing frames 106. When the protective cover 2 includes a cylindrical structure 4, the push arms 201 may be integral with the cylindrical structure 4; however, the push arms 201 may also be separately provided on the outside of the cylindrical structure 4.

[0093] In this embodiment, in order to facilitate the insertion of the push arm 201 into the push hole 107 and the simultaneous movement of the fixed frame 106 via the wedge-shaped surface 108, the plug-in end of the push arm 201 can be configured as a circular or arcuate surface. Alternatively, the plug-in end of the push arm 201 can also be configured as an inclined surface that mates with the wedge-shaped surface 108 on the wall of the push hole 107. This design can also achieve the pushing of the fixed frame 106. In other words, the plug-in end of the push arm 201 can be adjusted as desired while ensuring that the push arm 201 can simultaneously push the fixed frame 106 through the push hole 107. Detailed descriptions are omitted here.

[0094] In order to prevent the sealing plate 103 from being directly separated from the fixing plate 102, Figure 7 、 Figure 8As shown, the end of the fixing frame 106 away from the sealing plate 103 is further provided with a limiting buckle A109, and the delivery chamber 101 is further provided with a limiting buckle B120 that engages with the limiting buckle A109. When the limiting buckle A109 and the limiting buckle B120 are engaged, the limiting buckle A109 can slide on the limiting buckle B120, and the sliding direction of the limiting buckle A109 on the limiting buckle B120 is consistent with the reciprocating direction of the sealing plate 103. The cooperation between the limiting buckle A109 and the limiting buckle B120 not only ensures that the sealing plate 103 will not separate from the fixing plate 102, but also enables the sealing plate 103 to maintain normal sliding, ensuring that the sealing plate 103 and the fixing plate 102 are sealed and fitted when the protective cover 2 is placed on the suction nozzle 127.

[0095] In order to achieve relative sliding of the limiting buckle A109 and the limiting buckle B120 while being engaged, the limiting buckle A109 is a locking hook arranged relatively at the extended end of the fixed frame 106, the length between the bent part of the locking hook and the extended end of the fixed frame 106 is not less than the movement stroke of the sealing plate 103, and the bending direction of the two locking hooks is toward the central axis of the fixed frame 106; the limiting buckle B120 is T-shaped, and the distance between the two locking hooks in the limiting buckle A109 is greater than the vertical thickness of the limiting buckle B120 and less than the horizontal width of the limiting buckle B120. The degree of the limit buckle is adjusted so that the bent hooks of the two lock hooks are hung on both sides of the horizontal part of the limit buckle B120 and are located on both sides of the vertical part of the limit buckle B120. When the fixed frame 106 moves toward the sealing plate 103, the two lock hooks cooperate with the two sides of the horizontal part of the limit buckle B120 to effectively prevent the limit buckle A109 from detaching from the limit buckle B120. Since the fixed frame 106 is fixed to the limit buckle A109 and the sealing plate 103 is fixed to the fixed frame 106, the sealing plate 103 can be effectively prevented from detaching during the movement.

[0096] In order to make the sealing plate 103 automatically reset when the protective cover 2 is removed from the suction nozzle 127, Figure 1 、 Figure 5 As shown, a spring mounting hole 122 is further provided on the surface of the fixing plate 102 on the side close to the sealing plate 103. A spring 121 is installed in the spring mounting hole 122, and the other end of the spring 121 is fixed to the sealing plate 103. When the protective cover 2 is removed from the suction nozzle 127, the pushing arm 201 exits the pushing hole 107 on the fixing frame 106, and the fixing frame 106 loses the limit of the pushing arm 201. At this time, the spring 121 pushes the sealing plate 103 away from the fixing plate 102 through its own elastic force, so that the sealing plate 103 is separated from the fixing plate 102. When the sealing plate 103 is reset, it also drives the fixing frame 106 to reset. When the fixing frame 106 is reset, the limit buckle A109 moves toward the horizontal part of the limit buckle B120, so that the sealing plate 103 will not fall off when it is reset.

[0097] In this embodiment, the spring mounting hole 122 can also be opened on the surface of the sealing plate 103 close to the side of the fixed plate 102. In this case, one end of the spring 121 is fixed to the fixed plate 102, and the other end of the spring 121 is installed in the spring mounting hole 122 on the sealing plate 103. At the same time, spring mounting holes 122 can be opened on the opposite surfaces of the fixed plate 102 and the sealing plate 103. In this case, the two ends of the spring 121 are respectively installed in the two spring mounting holes 122, and the two ends of the spring 121 do not need to be fixed. This not only makes the installation and removal of the spring 121 more convenient, but also allows the two ends of the spring 121 to be limited by the spring mounting holes 122, so that the spring 121 can be evenly compressed. In order to make the thrust of the spring 121 on the sealing plate 103 more balanced when it is reset, two springs 121 are installed between the fixed plate 102 and the sealing plate 103, and the two springs 121 are symmetrically arranged around the center of the sealing plate 103.

[0098] In order to prevent the sealing plate 103 from tilting during the movement, Figure 5 、 Figure 6 、 Figure 7 As shown, a positioning post 123 is provided on the side of the fixed plate 102 near the sealing plate 103, and a sliding hole 124 is provided on the sealing plate 103 for the positioning post 123 to pass through. The sliding hole 124 slidably engages with the positioning post 123. Through the cooperation between the positioning post 123 and the sliding hole 124, the sealing plate 103 can be guided by the positioning post 123 during movement, making the movement of the sealing plate 103 more stable. To further ensure the smooth movement of the sealing plate 103, two guide posts are provided on the fixed plate 102, and the two guide posts are arranged symmetrically about the center of the fixed plate 102. In this case, there are also two sliding holes 124 on the sealing plate 103 that slidably engage with the positioning post 123.

[0099] In order to ensure the sealing effect when the sealing plate 103 and the fixed plate 102 are in contact with each other, a sealing ring 125 is further embedded on the side of the sealing plate 103 close to the fixed plate 102. The sealing ring 125 is located on the periphery of the mounting opening 104 on the fixed plate 102, so that the sealing effect is better when the sealing plate 103 and the fixed plate 102 are in contact with each other. Of course, in this embodiment, the sealing ring 125 can also be embedded on the surface of the fixed plate 102 close to the sealing plate 103, or the sealing ring 125 can also be embedded on the opposite surfaces of the fixed plate 102 and the sealing plate 103 at the same time. In addition, in this embodiment, the sealing ring 125 can also be replaced by a rubber gasket. In this case, the rubber gasket is directly attached to the surface of the fixed plate 102 close to the sealing plate 103, or attached to the surface of the sealing plate 103 close to the fixed plate 102, or attached to the opposite surfaces of the fixed plate 102 and the sealing plate 103 at the same time. When the sealing ring 125 is replaced by a rubber gasket, the rubber gasket also needs to be provided with a mounting opening 104 for the nozzle 126 to pass through, but the mounting opening 104 is matched with the nozzle 126 .

[0100] During production, one end of the spring 121 is inserted into the spring mounting hole 122 on the fixed plate 102, the sealing ring 125 is embedded in the sealing plate 103, and the sliding hole 124 on the sealing plate 103 cooperates with the positioning column 123, and the sealing plate 103 is installed above the fixed plate 102, and the other end of the spring 121 is inserted into the spring mounting hole 122 on the sealing plate 103; when the sealing plate 103 is installed, the fixing frame 106 passes through the fixing plate 103. 2 extends the avoidance opening 128 into the delivery chamber 101, and the limiting buckle A109 on the fixing frame 106 is buckled onto the limiting buckle B120; the aerosol can is installed in the accommodating chamber 100, and the valve stem of the metered dose valve on the aerosol can is inserted into the nozzle 126; finally, the desiccant 3 is installed in the cavity 200, and the cannula on the limiting rib 400 is inserted into the cavity 200, so that the limiting rib 400 presses and fixes the desiccant 3 in the cavity 200.

[0101] When using, such as Figure 11 As shown, the protective cover 2 is removed from the suction nozzle 127. When the protective cover 2 is removed, the push arm 201 exits the push hole 107 on the fixed frame 106, so that the fixed frame 106 loses the restriction of the push arm 201. At this time, the spring 121 pushes the sealing plate 103 away from the fixed plate 102 through its own elastic force, so that the sealing plate 103 is separated from the fixed plate 102. The sealing plate 103 drives the fixed frame 106 to reset while resetting. When the fixed frame 106 is reset, the limit buckle A109 moves toward the horizontal part of the limit buckle B120. At this time, the patient holds the suction nozzle 127 in his mouth and presses the aerosol can. The medicine in the aerosol can is sprayed out through the nozzle 126, and the sprayed medicine enters the patient's mouth through the delivery cavity 101 and the suction nozzle 127.

[0102] After use, if Figure 10As shown, the protective cover 2 is placed on the suction nozzle 127. While the protective cover 2 is being placed, the pushing arm 201 is gradually inserted into the pushing hole 107 on the fixed frame 106. As the protective cover 2 continues to be placed, the pushing arm 201 continues to be inserted. The pushing arm 201 cooperates with the wedge-shaped surface 108 on the inner wall of the pushing hole 107. While the pushing arm 201 is inserted, the fixed frame 106 is pushed toward the delivery chamber 101, thereby pulling the sealing plate 103 toward the fixed plate 102, and the spring 121 is gradually compressed. When the protective cover 2 is completely covered, the plug-in end of the pushing arm 201 is completely inserted into the pushing hole 107, the spring 121 is completely compressed, and the sealing plate 103 is sealed and fitted with the fixed plate 102. At this time, the delivery chamber 101 forms a completely enclosed space, and the desiccant 3 is exposed in the enclosed space, so that the desiccant 3 dries the enclosed space. Since the nozzle 126 is located in the delivery chamber 101 and the metered-dose valve stem on the aerosol can is inserted in the nozzle 126 , the desiccant 3 can dry the drug delivery channel of the nozzle 126 and the drug delivery channel of the metered-dose valve stem on the aerosol can while being delivered to the delivery chamber 101 .

[0103] The following is a comparison of the existing actuator without desiccant 3 as a comparative example 1 with the aerosol actuator with drying function provided in this embodiment. Figure 12 、 Figure 13 It can be seen that after the control driver was used with the drug once a day for 20 consecutive days, the valve stem, the spray hole and the inner wall of the nozzle 126 in the control driver were all in a state of scaling due to the drug absorbing moisture. Figure 14 、 Figure 15 It can be seen that after the same medication method is used, the valve stem, spray hole and inner wall of the nozzle 126 of the homemade actuator provided in this embodiment have only very slight drug scaling, which has a significant improvement effect. In addition, the difference between the homemade driver provided in this embodiment and the drug delivery system and related methods disclosed in the invention patent with application number 201880079337.2 is that the desiccant 3 in the homemade driver provided in this embodiment can not only dry the nozzle 126, the spray hole and the valve stem as a whole, but also dry the delivery chamber 101, the suction nozzle 127, and the protective cover 2, ensuring that drug scaling is formed in the nozzle 126, the spray hole, the valve stem, the delivery chamber 101, the suction nozzle 127, and the protective cover 2, thereby increasing the possibility of bacterial infection in the patient; while the invention patent with application number 201880079337.2 discloses a drug delivery system and related methods, in which the desiccant is installed in the protective cap, and the protective cap is directly sealed with the drug nozzle channel, so that the suction channel and the cover will not be dried, and the cover only plays a role in protecting dust and cannot seal moisture.

[0104] 1. Comparison of the spray pattern data of the self-made driver provided in this example

[0105] 1.1 Control driver spray pattern

[0106] Table 1-1: Control driver spray pattern data on day 1

[0107]

[0108]

[0109] Table 1-2: Control driver spray pattern data on day 10

[0110]

[0111] Table 1-3: Control driver spray pattern data on day 20

[0112]

[0113]

[0114] 1.2 Spray pattern of the homemade driver provided in this embodiment

[0115] Table 2-1: Spray pattern data of homemade actuator on day 1

[0116]

[0117] Table 2-2: Spray pattern data of the homemade driver on the 10th day

[0118]

[0119]

[0120] Table 2-3: Spray pattern data of the homemade driver on day 20

[0121]

[0122] Table 2-4: Spray pattern data of the homemade driver on day 30

[0123]

[0124]

[0125] According to the spray pattern data of the control driver and the self-made driver in Table 1-1 to Table 2-4, it can be seen that:

[0126] The budesonide control driver's FPF value decreased from 49.9% to 40.4% after 30 days, a decrease of 9.5%.

[0127] The formoterol fumarate control driver's FPF value decreased from 53.1% to 42.3% after 30 days, a decrease of 10.8%.

[0128] The control driver's glycopyrrolate FPF value decreased by 7.9% after 30 days, from 52.4% to 44.5%.

[0129] The FPF value of budesonide in the homemade driver decreased from 50.1% to 47.3% after 30 days, a decrease of 2.8%.

[0130] The FPF value of formoterol fumarate for the homemade driver decreased from 53.0% to 47.0% after 30 days, a decrease of 6%.

[0131] The FPF value of glycopyrrolate in the homemade driver decreased from 52.4% to 49.0% after 30 days, a decrease of 3.4%.

[0132] The custom actuator provided in this example significantly improved the FPF values of three API drugs. Furthermore, the above data show that after 30 days, the particle size of the custom actuator increased slightly, while the particle size of the control actuator increased significantly. As is well known, larger particle size reduces the therapeutic effect of inhaled drug formulations after pulmonary delivery. These data demonstrate that the custom actuator provided in this example significantly improves the delivery stability of various drugs.

[0133] 2. Comparison of driver area data between the driver and the self-made driver provided in this embodiment

[0134] 2.1 Spray area data at a distance of 3 cm from the driver

[0135] Table 3-1: Spray area data on the first day

[0136]

[0137] Table 3-2: Spray area data on the 10th day

[0138]

[0139] Table 3-3: Spray area data on the 20th day

[0140]

[0141]

[0142] Table 3-4: Spray area data on the 30th day

[0143]

[0144] 2.2 Spray area data at a distance of 6 cm from the driver

[0145] Table 4-1: Spray area data on the first day

[0146]

[0147] Table 4-2: Spray area data on the 10th day

[0148]

[0149] Table 4-3: Spray area data on the 20th day

[0150]

[0151]

[0152] Table 4-4: Spray area data on the 30th day

[0153]

[0154] According to the data in Table 3-1 to Table 4-4, the spray area data of the control driver and the homemade driver at 3cm for 30 days are as follows: the spray area of the control driver is 3.8cm after 30 days. 2 Down to 3.0cm 2 , down 0.8cm 2 After 30 days, the spray area of the self-made driver increased from 3.8cm 2 Down to 3.5cm 2 , down 0.3cm 2 .

[0155] The spray area data of the control driver and the self-made driver at 6 cm for 30 days are shown. The spray area of the control driver is 7.7 cm after 30 days. 2 Down to 5.8cm 2 , down 1.9cm 2 After 30 days, the spray area of the self-made driver increased from 8.0 cm 2 Down to 7.4cm 2 , down 0.6cm 2 .

[0156] The spray area of the homemade actuator provided in this embodiment decreases slightly at 3 cm and 6 cm, while the decrease of the control actuator is more obvious. Therefore, it can be seen that the homemade actuator provided in this embodiment has good stability in drug delivery.

[0157] 3. Data on the spray plume angle of the control driver and the self-made driver provided in this embodiment

[0158] Table 5-1: Driver spray angle data

[0159]

[0160] According to the data in Table 5-1, the 30-day spray angle data of the control driver and the homemade driver at 5.3 cm and 8.3 cm respectively, the spray angle of the control driver at 5.3 cm decreased from 19.8° to 12.4°, a decrease of 7.4°; the spray angle at 8.3 cm decreased from 22.6° to 14.7°, a decrease of 7.9°.

[0161] The spray angle of the homemade driver at 5.3 cm decreased from 19.6° to 17.2°, a decrease of 2.4°, and the spray angle at 8.3 cm decreased from 22.5° to 19.8°, a decrease of 2.7°.

[0162] The spray area of the homemade driver provided in this embodiment decreases very slightly at 5.3 cm and 8.3 cm, while the spray angle of the control driver decreases significantly. Therefore, it can be seen that the spray angle of drug delivery of the homemade driver provided in this embodiment has better stability.

[0163] Example 2

[0164] The difference between the aerosol driver with a drying function provided in this embodiment 2 and the aerosol driver with a drying function provided in embodiment 1 is that: Figures 16 to 25 As shown, the installation position and installation method of the desiccant 3 are different. Specifically, in this embodiment 2, the desiccant 3 is set in the delivery cavity 101.

[0165] In this embodiment 2, Figure 18 As shown, in order to place the desiccant 3 in the delivery chamber 101, a desiccant housing 5 is installed in the delivery chamber 101, and the desiccant 3 is installed in the desiccant housing 5. To ensure that the desiccant 3 can be fully released, the desiccant housing 5 is provided with through holes 500 communicating with its interior on one side, two sides, or all four sides.

[0166] In order to facilitate the installation and replacement of the desiccant 3, a groove adapted to the end of the drying shell 5 can be opened at the bottom of the delivery chamber 101, and an opening 129 for the drying shell 5 to be inserted can be opened on the fixing plate 102. Figure 20As shown, when the desiccant housing 5 containing the desiccant 3 needs to be installed, the desiccant housing 5 can be inserted into the groove at the bottom of the delivery chamber 101 through the opening 129 on the fixing plate 102, and the upper end of the desiccant housing 5 is kept inserted in the opening 129 on the fixing plate 102, thereby defining the ends of the desiccant housing 5 and completing the installation of the desiccant housing 5. Of course, when the desiccant housing 5 is installed in the above manner, it should be noted that in order to ensure the sealing fit between the sealing plate 103 and the fixing plate 102, the desiccant housing 5 cannot be higher than the upper surface of the fixing plate 102 after installation.

[0167] In this embodiment, if Figure 20 、 Figure 24 As shown, in order not to affect the spraying of the medicine by the nozzle 126, the covering of the protective cover 2 and the movement of the sealing plate 103, the drying housing 5 can be located behind the nozzle 126 or outside the limiting buckle B120 during installation, but the drying housing 5 cannot be located in front of the spray hole of the nozzle 126.

[0168] The aerosol driver with a drying function provided in this embodiment 2 is used in the same manner as the aerosol driver with a drying function provided in embodiment 1. The aerosol driver with a drying function provided in this embodiment 2 is assembled in the same manner as the aerosol driver with a drying function provided in embodiment 1, with the only difference being that the drying housing 5 containing the desiccant 3 must be installed before the sealing plate 103 is installed.

[0169] The following compares the existing actuator without desiccant 3 as control example 1 with the aerosol actuator with desiccant function provided in this embodiment. Figure 12 、 Figure 13 It can be seen that after the control driver used the drug once a day for 20 consecutive days, the valve stem, spray hole and inner wall of the nozzle 126 of the control device had obvious scaling caused by drug absorption. Figure 26 、 Figure 27 As can be seen, after the same medication application, the self-produced actuator provided in this embodiment exhibited only very slight drug scaling on the valve stem, spray hole, and inner wall of nozzle 126, demonstrating significant improvement. Furthermore, the self-produced actuator provided in this embodiment differs from the drug delivery system and related methods disclosed in patent application number 201880079337.2 in that the desiccant 3 in the self-produced actuator provided in this embodiment can dry out nozzle 126, spray hole, and valve stem as a whole, ensuring that drug scaling within nozzle 126 is eliminated, thereby reducing the likelihood of bacterial infection in patients.

[0170] 1. Comparison of the spray pattern data of the self-made driver provided in this example

[0171] 1.1 Spray pattern of control driver

[0172] Table 6-1: Spray pattern data of control driver on day 1

[0173]

[0174] Table 6-2: Spray pattern data of control driver on day 10

[0175]

[0176]

[0177] Table 6-3 Spray pattern data of control driver on the 20th day

[0178]

[0179] Table 6-4 Spray pattern data of control driver on day 30

[0180]

[0181]

[0182] 1.2 Spray pattern of the homemade driver provided in this embodiment

[0183] Table 7-1: Spray pattern data of the homemade driver on the first day

[0184]

[0185] Table 7-2: Spray pattern data of the homemade driver on the 10th day

[0186]

[0187]

[0188] Table 7-3: Spray pattern data of the homemade driver on the 20th day

[0189]

[0190] Table 7-4: Spray pattern data of the homemade driver on the 30th day

[0191]

[0192]

[0193] According to the spray pattern data of the control driver and the self-made driver in Table 6-1 to Table 7-4, it can be seen that:

[0194] The budesonide control driver's FPF value decreased from 49.9% to 40.4% after 30 days, a decrease of 9.5%.

[0195] The formoterol fumarate control driver's FPF value decreased from 53.1% to 42.3% after 30 days, a decrease of 10.8%.

[0196] The FPF value of the control driver treated with glycopyrrolate decreased by 7.9% from 52.4% to 44.5% after 30 days.

[0197] The FPF value of budesonide in the homemade driver decreased from 50.1% to 47.3% after 30 days, a decrease of 2.8%.

[0198] The FPF value of the homemade driver, formoterol fumarate, decreased from 53.1% to 47.5% after 30 days, a decrease of 5.6%.

[0199] The FPF value of glycopyrrolate in the homemade driver decreased from 52.4% to 48.9% after 30 days, a decrease of 3.5%.

[0200] The custom actuator provided in this example significantly improved the FPF values of three API drugs. Furthermore, the above data show that after 30 days, the particle size of the custom actuator increased slightly, while the particle size of the control actuator increased significantly. As is well known, larger particle size reduces the therapeutic effect of inhaled drug formulations after pulmonary delivery. These data demonstrate that the custom actuator provided in this example significantly improves the delivery stability of various drugs.

[0201] 2. Comparison of driver area data between the driver and the self-made driver provided in this embodiment

[0202] 2.1 Spray area data at a distance of 3 cm from the driver

[0203] Table 8-1: Spray area data on the first day

[0204]

[0205] Table 8-2: Spray area data on the 10th day

[0206]

[0207]

[0208] Table 8-3: Spray area data on the 20th day

[0209]

[0210] Table 8-4: Spray area data on the 30th day

[0211]

[0212] 2.2 Spray area data at a distance of 6 cm from the driver

[0213] Table 9-1: Spray area data on the first day

[0214]

[0215] Table 9-2: Spray area data on the 10th day

[0216]

[0217]

[0218] Table 9-3: Spray area data on the 20th day

[0219]

[0220] Table 9-4: Spray area data on the 30th day

[0221]

[0222] According to the data in Table 8-1 to Table 9-4, the spray area data of the control driver and the self-made driver at 3cm for 30 days are as follows: the spray area of the control driver is 3.8cm after 30 days. 2 Down to 3.0cm 2 , down 0.8cm 2 After 30 days, the spray area of the self-made driver increased from 3.8cm 2 Down to 3.4cm 2 , down 0.4cm 2 .

[0223] The spray area data of the control driver and the self-made driver at 6 cm for 30 days are shown. The spray area of the control driver is 7.7 cm after 30 days. 2 Down to 5.8cm 2 , down 1.9cm 2 After 30 days, the spray area of the self-made driver was increased from 8.5cm 2 Down to 7.5cm 2 , down 1.0cm 2 .

[0224] The spray area of the homemade actuator provided in this embodiment decreases slightly at 3 cm and 6 cm, while the decrease of the control actuator is more obvious. Therefore, it can be seen that the homemade actuator provided in this embodiment has good stability in drug delivery.

[0225] 3. Data on the spray plume angle of the control driver and the self-made driver provided in this embodiment

[0226] Table 10-1: Spray Angle Data

[0227]

[0228] According to the data in Table 10-1, the 30-day spray angle data of the control driver and the homemade driver at 5.3 cm and 8.3 cm respectively show that the spray angle of the control driver at 5.3 cm decreased from 19.8° to 12.4°, a decrease of 7.4°; the spray angle at 8.3 cm decreased from 22.6° to 14.7°, a decrease of 7.9°.

[0229] The spray angle of the homemade driver at 5.3 cm decreased from 19.5° to 17.4°, a decrease of 2.1°, and the spray angle at 8.3 cm decreased from 22.8° to 19.3°, a decrease of 3.5°.

[0230] The spray area of the actuator provided in this embodiment decreases slightly at 5.3 cm and 8.3 cm, while the spray angle of the control actuator decreases significantly. Therefore, it can be seen that the spray angle of the homemade actuator drug delivery provided in this embodiment has better stability.

[0231] Comparative Example 2

[0232] The control driver provided in this comparative example 2 is different from the aerosol driver with drying function provided in Example 1 in that: Figures 28 to 35 As shown, the design of the sealing structure is cancelled, so that the accommodating chamber 100 is connected with the delivery chamber 101, and the pushing arm 201 provided in the protective cover 2 is correspondingly cancelled. The structure of the desiccant 3 provided in the protective cover 2 is adjusted. The specific adjustment method is as follows:

[0233] like Figure 29 As shown, the cylindrical structure 4 provided on the protective cover 2 is modified into two semicircular buckles 200' arranged opposite to each other, forming an insertion port 201' between the two semicircular buckles 200', and a cylindrical shell 202' is inserted into the insertion port 201'. The inner wall of the cylindrical shell 202' is provided with a plurality of positioning ribs 204' at one end close to the protective cover 2, and the plurality of positioning ribs 204' are evenly spaced and arranged along the circumference of the cylindrical shell 202'. Figure 33As shown, the desiccant 3 is cylindrical and is inserted into the cylindrical shell 202'. Since the inner wall of the cylindrical shell 202' has positioning ribs 204', after the desiccant 3 is inserted into the cylindrical shell 202', an annular channel 6 is formed between the outer surface of the desiccant 3 and the inner wall of the cylindrical shell 202', and the four sides of the desiccant 3 and the side of the desiccant 3 pressed by the limiting ribs 400 can be fully released.

[0234] In order to prevent the cylindrical shell 202' from falling off when inserted into the plug port 201', Figure 30 As shown, the outer circular surface of the cylindrical shell 202' is in the shape of a stepped shaft, so that the cylindrical shell 1 has a circular stepped surface 205', and the large diameter end and length of the cylindrical shell 202' are adapted to the diameter and depth of the plug-in port 201'; at the same time, ridges 206' are provided on the two semicircular clips 200' to engage with the circular stepped surface 205'. When the cylindrical shell 1 is inserted into the plug-in port 201', the ridges 206' on the two semicircular clips 200' are engaged with the circular stepped surface 205' on the cylindrical shell 1, thereby clamping the cylindrical shell 1 in the plug-in port 201', effectively preventing the cylindrical shell 1 from falling off.

[0235] In addition, if Figure 30 、 Figure 34 As shown, a cross rib 207' is provided on the end of the cylindrical shell 202' away from the protective cover 2. An annular soft rubber pad 208' is also fixed to the side of the cross rib 207' away from the protective cover 2. A circular boss 209' is also provided on the nozzle 126. The circular boss 209' is located outside the nozzle orifice of the nozzle 126 and mates with the annular soft rubber pad 208'. When the protective cover 2 is placed on the suction nozzle 127 of the housing 1, the circular boss 209' on the nozzle 126 abuts against the annular soft rubber pad 208', sealing the nozzle opening of the nozzle 126 with the cylindrical shell 202'.

[0236] During production, the aerosol can is installed in the accommodating chamber 100, and the valve stem of the metered-dose valve on the aerosol can is inserted into the nozzle 126. Next, the cylindrical desiccant 3 is inserted into the cylindrical shell 202', and the cylindrical shell 202' is inserted between the two semicircular clips 200'. When the ridges 206' on the semicircular clips 200' come into contact with the circular stepped surface 205' on the cylindrical shell 1, the cylindrical shell 202' is clamped and fixed.

[0237] When in use, remove the protective cover 2 from the mouthpiece 127, hold the mouthpiece 127 in the patient's mouth, press the aerosol can, and the medicine in the aerosol can is sprayed out through the nozzle 126. The sprayed medicine enters the patient's mouth through the delivery cavity 101 and the mouthpiece 127. Figure 35As shown, the protective cover 2 is placed on the suction nozzle 127, and the circular boss 209' on the nozzle 126 is pressed against the annular soft rubber pad 208', so that the nozzle of the nozzle 126 is sealed and connected to the cylindrical housing 202'. The cylindrical housing 202', the nozzle 126 and the valve stem of the metered dose valve on the aerosol can are connected, and the desiccant 3 can fully dry the nozzle 126 and the valve stem of the metered dose valve on the aerosol can.

[0238] Depend on Figure 36 、 Figure 37 It can be seen that after the control actuator provided in this comparative example was used with the drug once a day for 20 consecutive days, the valve stem, the spray hole and the inner wall of the nozzle 126 of the control actuator were obviously scaled due to the drug absorbing moisture.

[0239] 1. Comparison of the spray pattern data of the driver

[0240] Table 11-1: Control driver spray pattern data on day 1

[0241]

[0242]

[0243] Table 11-2: Control driver spray pattern data on day 10

[0244]

[0245]

[0246] Table 11-3: Control driver spray pattern data on day 20

[0247]

[0248] Table 11-4: Control driver spray pattern data on day 30

[0249]

[0250]

[0251] According to the spray pattern data of the control driver in Table 11-1 to Table 11-4, it can be seen that:

[0252] The budesonide control driver's FPF value decreased from 49.9% to 44.9% after 30 days; a decrease of 5.0%.

[0253] The formoterol fumarate control driver showed a 9.3% decrease in FPF value from 53.0% to 43.7% after 30 days.

[0254] The FPF value of the control driver treated with glycopyrrolate decreased by 5.2% from 52.2% to 47.0% after 30 days.

[0255] The data of the control-designed driver show that the spray particle size of the control driver increases significantly after 30 days, and the FPF value decreases significantly.

[0256] 2. Compare the drive area data

[0257] 2.1 Control driver spray area data at a spray distance of 3cm

[0258] Table 12-1: Spray area data on the first day

[0259]

[0260] Table 12-2: Spray area data on the 10th day

[0261]

[0262]

[0263] Table 12-3: Spray area data on the 20th day

[0264]

[0265] Table 12-4: Spray area data on the 30th day

[0266]

[0267] 2.2 Control driver spray area data at a spray distance of 6 cm

[0268] Table 13-1: Spray area data on the first day

[0269]

[0270] Table 13-2: Spray area data on the 10th day

[0271]

[0272] Table 13-3: Spray area data on the 20th day

[0273]

[0274] Table 13-4: Spray area data on the 30th day

[0275]

[0276] According to the data in Table 12-1 to Table 13-4, the spray area of the control driver at 3 cm increased from 4.2 cm to 3.3 cm after 30 days. 2 Down to 3.3cm 2 , down 0.9cm 2 After 30 days, the spray area of the control driver at 6 cm was increased from 8.0 cm 2 Down to 6.3cm 2 , down 1.7cm 2 .

[0277] The decrease in the control driver was more obvious, and the control driver had poor stability in drug delivery.

[0278] 3. Comparison of drive spray plume angle data

[0279] Table 14-1: Driver spray angle data

[0280]

[0281] According to the data in Table 14-1, the 30-day spray angle data of the control driver at 5.3 cm and 8.3 cm showed that the spray angle of the control driver at 5.3 cm decreased from 21.6° to 14.5°, a decrease of 7.1°; the spray angle at 8.3 cm decreased from 22.6° to 16.5°, a decrease of 6.1°.

[0282] It should be noted that the points of 3 cm, 6 cm, 5.3 cm and 8.3 cm in this manual are all based on the nozzle outlet, and the MMAD in this manual is the particle size, and FPF is the effective site deposition amount.

[0283] It should be understood by those skilled in the art that the above embodiments are merely for the purpose of illustrating the present invention clearly, and are not intended to limit the scope of the present invention. For those skilled in the art, other changes or modifications may be made based on the above disclosure, and these changes or modifications are still within the scope of the present invention.

Claims

1. An aerosol driver with a drying function, characterized in that: include: A housing (1) having a sealing structure therein, the sealing structure dividing the interior of the housing (1) into a receiving chamber (100) for mounting an aerosol can and a delivery chamber (101) for delivering a drug, a nozzle (126) connected to a discharge port of a metered-dose valve stem on the aerosol can being mounted in the delivery chamber (101), the sealing structure having a mounting opening (104) in sealing engagement with the nozzle (126); the housing (1) also having a suction nozzle (127) in communication with the delivery chamber (101); and a protective cover (2), wherein the protective cover (2) is used to open or close the delivery chamber (101), and a desiccant (3) is further provided in the delivery chamber (101) or the protective cover (2).

2. The aerosol driver with drying function according to claim 1, characterized in that: A cavity (200) is provided in the protective cover (2), and the desiccant (3) is installed in the cavity (200); preferably, a limiting rib (400) for pressing the desiccant (3) is also provided in the protective cover (2); preferably, an annular channel (6) is formed between the periphery of the desiccant (3) and the inner wall of the cavity (200).

3. The aerosol driver with drying function according to claim 1, characterized in that: A drying shell (5) is installed in the delivery chamber (101), a desiccant (3) is installed in the drying shell (5), and a through hole (500) is provided on a side of the drying shell (5); preferably, the desiccant (3) is in granular, powdery or blocky form.

4. The aerosol driver with drying function according to claim 2 or 3, characterized in that: The sealing structure comprises a fixing plate (102) fixed inside the housing (1) and a sealing plate (103) that can be moved closer to or farther away from the fixing plate (102); when the protective cover (2) is installed, the sealing plate (103) and the fixing plate (102) are in sealing contact, and the mounting opening (104) on the sealing plate (103) and the nozzle (126) are in sliding sealing contact.

5. The aerosol driver with drying function according to claim 4, characterized in that: The sealing plate (103) is further provided with a fixing frame (107) which passes through the fixing plate (102) and extends into the delivery cavity (101). The protective cover (2) and the fixing frame (107) are provided with a plug-in structure, which enables the protective cover (2) to be covered while pulling the sealing plate (103) and the fixing plate (102) into contact.

6. The aerosol driver with drying function according to claim 5, characterized in that: The plug-in structure comprises a pushing hole (107) provided on a fixed frame (107) and a pushing arm (201) provided on a sealing plate (103); a wedge-shaped surface (108) matching with the pushing arm (201) is provided on the hole wall of the pushing hole (107).

7. The aerosol driver with drying function according to claim 5, characterized in that: The extending end of the fixing frame (107) is further provided with a limiting buckle A (109), and the delivery cavity (101) is further provided with a limiting buckle B (120) engaged with the limiting buckle A (109), and the limiting buckle A (109) can slide on the limiting buckle B (120) along the movement direction of the sealing plate (103).

8. The aerosol driver with drying function according to claim 7, characterized in that: The limiting buckle A (109) is composed of two locking hooks arranged opposite to each other, and the limiting buckle B (120) is T-shaped, and the two locking hooks in the limiting buckle A (109) are respectively hung on both sides of the limiting buckle B (120).

9. The aerosol driver with drying function according to claim 4, characterized in that: A spring (121) is further installed between the fixing plate (102) and the sealing plate (103); preferably, a spring installation hole (122) is further provided on the fixing plate (102) or / and the sealing plate (103), and the end of the spring (121) is installed in the spring (121) hole.

10. The aerosol driver with drying function according to claim 4, characterized in that: The fixing plate (102) is also provided with a positioning column (123), and the sealing plate (103) is also provided with a sliding hole (124) that slides with the positioning column (123); preferably, a sealing ring (125) is also provided on the fitting surface of the sealing plate (103) or the fitting surface of the fixing plate (102).

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