Composition and application thereof in preparation of product with eczema treatment effect

Abstract

The invention relates to a composition and application thereof in preparation of a product with an eczema treatment effect. The composition mainly comprises the following components: aesculus chinensis, radix rehmanniae recen, liquorice, semen coicis, golden cypress, coptis chinensis, rhizoma atractylodis, schizonepeta, poria cocos and radix angelicae. According to the invention, the main medicinal materials are firstly crushed, then boiled with water to extract beneficial components, and finally effective components are concentrated for nano-liposome embedding treatment, so that the loss of the beneficial components of the medicinal materials is effectively prevented, and meanwhile, the absorption of the body is promoted. The traditional Chinese medicine composition and the traditional Chinese medicine extract provided by the invention are natural in raw materials, wide in source and simple in preparation method, have a remarkable treatment effect on acute eczema, subacute eczema and chronic eczema, can remarkably improve skin symptoms such as itching, papule, seepage, erythema, skin lesion erosion and the like of patients, are exact in curative effect, are not easy to relapse after being cured, and are free of toxic and side effects. Good clinical application values are realized.

Description

Technical Field

[0001] The present invention belongs to the field of pharmaceutical technology, and specifically relates to a composition and an application thereof in preparing a product having the effect of treating eczema. Technical Background

[0002] Eczema is a common skin disease characterized by redness, itching, blistering, and scabs. Treatment options for eczema include topical medications, moisturizing, and avoiding irritation, while systemic treatments include oral medications, phototherapy, and biologics.

[0003] In traditional Chinese medicine theory, eczema is usually classified into wind-heat eczema, damp-heat eczema, blood-heat eczema, blood stasis eczema, qi stagnation eczema, qi and blood deficiency type eczema, and blood deficiency and wind-dryness type eczema, etc. according to its clinical manifestations, causes and physical characteristics.

[0004] The clinical manifestations of eczema are diverse, the main manifestations of which are redness and swelling of the skin, that is, redness and swelling of the affected area, sometimes accompanied by exudation; itching is the most common symptom of eczema, and patients often feel unbearable itching of the skin; blisters are small blisters that may appear on the red and swollen skin, which sometimes rupture and exude; scabs are formed on the skin surface after the blisters rupture.

[0005] There are two main treatment methods for eczema: local treatment and systemic treatment. Local treatments include topical medications such as corticosteroids, antihistamines, and topical antibiotics, which are used to relieve symptoms such as itching and redness. Systemic treatments include oral medications such as antihistamines and immunosuppressants, which are used to control flare-ups.

[0006] CN118557643A discloses a Chinese medicine composition for treating eczema and its preparation method. The Chinese medicine composition contains raw rehmannia root, red peony root, white peony root, angelica root, stir-fried peach kernel, Chuanxiong root, Cynanchum chinense, Kochia scoparia fruit, Dictamni root, Herba schizonepetae, Saposhnikovia divaricata, and Perilla leaf. Pharmacological experiments have shown that the Chinese medicine composition has anti-inflammatory, antipruritic, and anti-allergic effects. Clinical trials have confirmed that the effective rate and cure rate of eczema patients treated with the Chinese medicine composition are good. In clinical use, the Chinese medicine composition has a significant therapeutic effect and good clinical safety.

[0007] CN117018128A discloses a Chinese medicine composition for treating eczema, its preparation method, and application. The invention provides a Chinese medicine composition for treating eczema, belonging to the field of traditional Chinese medicine technology. The composition is prepared from the following Chinese medicine raw materials in parts by weight: 5-30 parts of Dictamni Cortex, 5-30 parts of Tribulus Terrestris, 5-30 parts of Phellodendron Amurense, 5-30 parts of Sophora Flavescentis, 10-30 parts of Rehmannia Glutinosa, 5-30 parts of Salvia Miltiorrhiza, 10-30 parts of Coix Seed, 5-30 parts of Poria, 5-30 parts of Stir-fried Atractylodes Macrocephala, 5-30 parts of Codonopsis Pilosula, and 5-30 parts of Radix Glycyrrhizae Preparata. The eleven Chinese medicines described in the invention have a synergistic effect, with the effects of clearing heat and detoxifying, strengthening the spleen and removing dampness. For eczema characterized by spleen deficiency and dampness, the composition can effectively reduce the EASI score and VAS score of skin lesions, treating both the symptoms and the root cause, with a high cure rate, a low recurrence rate, and minimal side effects on the human body. The composition is particularly suitable for the treatment of patients with eczema.

[0008] The technical problems of the above patents are: 1. Although symptoms can be alleviated after use, the recurrence rate is high; 2. The traditional decoction process is used, resulting in low drug utilization rate; Summary of the Invention

[0009] The Chinese medicine composition prepared by the present invention has a good effect on treating eczema, and the Chinese medicine composition has a fast effect, high efficacy and high drug utilization rate; The main purpose of the present invention is to provide a composition and its use in preparing a product having the effect of treating eczema; First, the present invention provides a traditional Chinese medicine composition containing horse chestnut, raw rehmannia root, liquorice, coix seed, phellodendron, coptis root, atractylodes, schizonepeta, poria, and angelica dahurica; Furthermore, the Chinese medicine composition is mainly prepared from the following raw materials, in parts by weight: 10-15 parts of Aesculus fragrans leaves, 10-15 parts of Rehmannia root, 5-10 parts of Licorice root, 3-6 parts of Coix seeds, 2-5 parts of Phellodendron amurense, 1-3 parts of Coptis chinensis, 2-5 parts of Atractylodes lancea, 3-6 parts of Schizonepeta tenuifolia, 1-5 parts of Poria cocos, and 3-6 parts of Angelica dahurica; Furthermore, the Chinese medicine composition is mainly prepared from the following raw materials, in parts by weight: 10-13 parts of Aesculus fragrans leaves, 10-14 parts of Rehmannia root, 5-8 parts of Licorice root, 3-6 parts of Coix seeds, 2-4 parts of Phellodendron amurense, 1-3 parts of Coptis chinensis, 2-5 parts of Atractylodes macrocephala, 3-5 parts of Schizonepeta tenuifolia, 1-4 parts of Poria cocos, and 3-5 parts of Angelica dahurica; Furthermore, the Chinese medicine composition is mainly prepared from the following raw materials, in parts by weight: 10-13 parts of Aesculus fragrans leaves, 10-14 parts of Rehmannia root, 5-8 parts of Licorice root, 3-6 parts of Coix seeds, 2-4 parts of Phellodendron amurense, 1-3 parts of Coptis chinensis, 2-5 parts of Atractylodes lancea, 3-5 parts of Schizonepeta tenuifolia, 1-4 parts of Poria cocos, and 3-5 parts of Angelica dahurica; Preferably, the Chinese medicine composition is mainly prepared from the following raw materials, in parts by weight: 11 parts of Aesculus fragrans leaves, 13 parts of Rehmannia root, 6 parts of Licorice root, 4 parts of Coix seeds, 2 parts of Phellodendron amurense, 2 parts of Coptis chinensis, 4 parts of Atractylodes lancea, 3 parts of Schizonepeta tenuifolia, 3 parts of Poria cocos, and 4 parts of Angelica dahurica; The present invention also provides a method for preparing the Chinese medicine composition: Step 1: Take each amount of the Chinese medicinal components, grind them through a 40-60 mesh sieve, continue to add water to extract for 1-1.5 hours, decoct for 2-3 hours, and filter with 300-400 mesh gauze to obtain the residue and the primary liquid; Step 2: continue to boil the residue obtained in step 1 at 50-60 degrees Celsius for 1-2 hours, and filter through 300-400 mesh gauze to obtain a secondary medicinal solution; Step 3: Combine the primary and secondary drug solutions obtained in Steps 1 and 2 above, add nanoliposomes, and continue concentrating at 60-80 degrees Celsius and a negative pressure of 0.08-0.11 MPa to obtain an extract concentrate; Step 4: Dry the extract obtained in step 3 above at 60-80 degrees Celsius and a negative pressure of 0.08-0.11 MPa to obtain a dry paste, grind it, and add appropriate amounts of auxiliary materials and binders to granulate it; The water-to-material ratio in step 1 is (10-20) ml:1 g, more preferably 15 ml:1 g; In the above step 2, the water-to-material ratio is (10-15) ml:1 g; more preferably 13 ml:1 g; The auxiliary material is dextrin, and its amount is the same as the weight of the crushed dry paste; The binder is ethanol with a volume fraction of 70-95%, more preferably 80-90%; The present invention also discloses the preparation steps of the nanoliposome embedding in step 3, which are as follows: S1. Weigh a certain amount of soybean lecithin and β-sitosterol and dissolve them in anhydrous ethanol at a mass ratio of 7-10:1. Ultrasonicate and evaporate in a preheated rotary evaporator under vacuum to remove the ethanol. S2. After the organic solvent evaporates, a thin film appears on the bottle wall. Continue rotary evaporation and the film collapses. S3. The extracted primary and secondary liquids were combined and poured into an evaporating flask. After 30-40 minutes, the film completely encapsulated the active ingredient of the liquid, the liquid was poured out, and ultrasonication was continued for 10-20 minutes. The mass ratio of soybean lecithin to β-sitosterol is (7-10):1, more preferably 8:1; The main functions of various ingredients in the present invention are as follows: Horse chestnut leaves, commonly used to treat varicose veins and hemorrhoids, have seed extracts that have anti-inflammatory, astringent, and vascular strengthening properties. Eczema treatment: May reduce inflammation caused by eczema through its anti-inflammatory properties. In composition: May help reduce skin redness and inflammation caused by eczema. In composition: May help reduce skin redness and inflammation caused by eczema. Dictamnus cortex, Dictamnus cortex is the root bark of the perennial herb Dictamnus and Dictamnus angustifolia of the Rutaceae family. Traditional Chinese medicine believes that Dictamnus cortex has the effects of clearing heat and dampness, dispelling wind and detoxifying. Modern research shows that Dictamnus cortex mainly contains alkaloids, steroids, limonoids, flavonoids and other compounds. The extract of Dictamnus cortex has anti-allergic, antibacterial, anti-cancer, anti-inflammatory and nerve-protecting effects. The treatment method of fumigation or sitz bath with the decoction of Dictamnus cortex compound can clear heat and dampness, relieve itching and kill bacteria, and its water extract has antipyretic and anti-inflammatory effects. In vitro and in vivo experiments have shown that the water extract and ethanol extract of Dictamnus cortex have different degrees of antibacterial effects on many skin fungi such as Trichophyton concentricus, Trichophyton thunbergii and Trichophyton rubrum; Raw Rehmannia root has the effects of nourishing yin and reducing fire, clearing heat and cooling blood, and is often used to treat various symptoms caused by blood heat; its therapeutic effect on eczema: it may relieve skin itching and inflammation caused by eczema by clearing heat and cooling blood; its role in the composition: it may help regulate dampness and heat in the body, thereby alleviating eczema symptoms.

[0010] Licorice, also known as "beauty grass," "honey grass," and "national elder," is the dried root and rhizome of the leguminous plants Glycyrrhiza uralensis, Glycyrrhiza inflata, and Glycyrrhiza glabra. Glycyrrhizin, extracted and refined from licorice, is used in cosmetics and skincare products to regulate the skin's immune function, enhance its disease resistance, eliminate inflammation, prevent allergies, and cleanse the skin. It also eliminates adverse reactions to cosmetics and other external factors, maintains the emulsified state of the product for a long time, and prevents oxidation and deterioration. Job's tears seed has diuretic and dampness-inducing properties, strengthens the spleen, and relieves diarrhea, and is commonly used to treat edema and dampness in the middle jiao. Its eczema-treating properties may help eliminate excess water from the body through its diuretic and dampness-inducing properties, alleviating edema caused by eczema. Its role in compositions may help regulate water balance in the body and alleviate skin edema caused by eczema. Phellodendron amurense is bitter and cold, and enters the kidney, bladder, and large intestine meridians; it clears away heat and dampness, purges fire and detoxifies, and reduces fever; modern pharmacological studies have shown that Phellodendron amurense has antibacterial, anti-inflammatory, and antioxidant effects on the skin. The combination of Coptis chinensis and Phellodendron amurense has pharmacological effects such as anti-infection, antibacterial, anti-inflammatory, antipyretic, and antipruritic. The combination of Coptis chinensis and Phellodendron amurense can eliminate hydroxyl free radicals. Atractylodes lancea is pungent, bitter, and warm, and enters the kidney and stomach meridians; it can dry out dampness, strengthen the spleen, dispel rheumatism, and release the exterior. Modern pharmacological studies have shown that Atractylodes lancea has the effects of regulating gastrointestinal function, regulating immunity, and having anti-inflammatory, antibacterial, and anti-tumor effects. Schizonepeta, with its antipyretic and anti-itching properties, is commonly used to treat colds and urticaria. Eczema treatment: It may relieve itching caused by eczema through its antipruritic and anti-rash properties. Its role in the composition: It may help relieve skin itching caused by eczema. Poria cocos detoxifies, removes dampness, and promotes joint function. It is used for limb cramps and muscle and bone pain caused by syphilis and mercury poisoning; damp-heat stranguria, leukorrhea, carbuncles, scrofula, and scabies. Poria cocos has diuretic and dampness-eliminating properties, strengthens the spleen, and calms the mind, and is commonly used to treat edema and insomnia. Its eczema-treating properties may help eliminate excess water from the body through its diuretic and dampness-eliminating properties. Its role in composite compositions may help regulate water balance and alleviate edema caused by eczema. Angelica dahurica has the effects of dispelling cold, expelling wind and relieving pain, and is often used to treat colds and headaches. Its role in treating eczema is to relieve skin symptoms caused by eczema by dispelling wind. Its role in the composition is to help relieve skin discomfort caused by eczema. Beneficial technical effects of the present invention: 1. The Chinese medicine composition and Chinese medicine extract provided by the present invention have natural raw materials with a wide source, simple preparation method, no organic solvents, safe and reliable, low cost, and synergistic effect between the components to achieve the purpose of preventing and treating eczema by clearing away heat and dampness, strengthening the middle jiao, and regulating the spleen and stomach qi; 2. The Chinese medicine composition and Chinese medicine extract provided by the present invention have significant therapeutic effects on acute eczema, subacute eczema and chronic eczema, and can significantly improve patients' skin symptoms such as itching, papules, exudation, erythema, skin lesions and erosions. The efficacy is definite and recurrence is not easy after cure, which has good clinical application value. DETAILED DESCRIPTION

[0011] Before further describing the specific embodiments of the present invention, it should be understood that the scope of the present invention is not limited to the specific embodiments described below. It should also be understood that the terminology used in the examples is intended to describe specific embodiments and is not intended to limit the scope of the present invention. The experimental procedures in the following examples, where specific conditions are not specified, were generally performed under conventional conditions or according to the conditions recommended by the respective manufacturers.

[0012] When the embodiments provide numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as those generally understood by those skilled in the art. In addition to the specific methods, equipment, and materials used in the embodiments, according to the prior art mastery and the description of the present invention by those skilled in the art, any methods, equipment, and materials of the prior art similar or identical to the methods, equipment, and materials described in the embodiments of the present invention may also be used to implement the present invention.

[0013] Unless otherwise specified, the test methods, detection methods, and preparation methods disclosed in the present invention all adopt conventional techniques in this technical field.

[0014] Example 1 A Chinese medicine composition, characterized in that the preparation method is as follows: Step 1: Take 11 parts of Aesculus fragrans leaves, 13 parts of Rehmannia root, 6 parts of Licorice root, 4 parts of Coix seeds, 2 parts of Phellodendron chinense, 2 parts of Coptis chinensis, 4 parts of Atractylodes lancea, 3 parts of Schizonepeta tenuifolia, 3 parts of Poria cocos, and 4 parts of Angelica dahurica, grind them through a 60-mesh sieve, continue to add water to extract for 1.5 hours, decoct for 2 hours, and use a water-to-material ratio of 15 ml:1 g. Continue to filter with 400-mesh gauze to obtain the residue and the primary liquid; Step 2: continue to boil the medicinal residue obtained in step 1 at 60 degrees Celsius for 1.5 hours, with a water-to-material ratio of 13 ml: 1 g, and continue to filter with 400 mesh gauze to obtain a secondary medicinal solution; Step 3: The primary and secondary drug solutions obtained in Steps 1 and 2 are combined, embedded in nanoliposomes, and further concentrated at 60 degrees Celsius and a negative pressure of 0.1 MPa to obtain an extract concentrate; Step 4: Dry the extract obtained in the above step 3 at 70 degrees Celsius and a negative pressure of 0.1 MPa to obtain a dry paste, grind it, add dextrin, an auxiliary material with the same weight as the dry paste, and granulate it with an appropriate amount of 85% volume fraction ethanol.

[0015] The present invention also discloses the preparation steps of the nanoliposomes in step 3 above: S1. Weigh a certain amount of soybean lecithin and β-sitosterol, dissolve them in anhydrous ethanol in a mass ratio of 8:1, and ultrasonically dissolve them in anhydrous ethanol. Place them on a preheated rotary evaporator and evaporate them under vacuum to remove the ethanol. S2. After the organic solvent evaporates, a thin film appears on the bottle wall. Continue rotary evaporation and the film collapses. S3. Combine the extracted primary and secondary drug solutions and pour them into an evaporating flask. After 35 minutes, the film will completely encapsulate the active ingredients of the drug solution. Pour out the liquid and continue ultrasonication for 15 minutes.

[0016] Example 2 The difference between Example 2 and Example 1 is that the Chinese medicinal components in Example 2 are: 10 parts of Aesculus fragrans, 11 parts of Rehmannia root, 7 parts of Licorice root, 5 parts of Coix seed, 3 parts of Phellodendron amurense, 1 part of Coptis chinensis, 4 parts of Atractylodes lancea, 4 parts of Schizonepeta tenuifolia, 3 parts of Poria cocos, and 4 parts of Angelica dahurica.

[0017] Example 3 The difference between Example 3 and Example 1 is that the Chinese medicinal components in Example 2 are: 13 parts of Aesculus fragrans, 7 parts of Rehmannia root, 7 parts of Licorice root, 4 parts of Coix seed, 2 parts of Phellodendron chinense, 2 parts of Coptis chinensis, 4 parts of Atractylodes lancea, 4 parts of Schizonepeta tenuifolia, 4 parts of Poria cocos, and 5 parts of Angelica dahurica.

[0018] Comparative Example 1

[0019] The difference between Comparative Example 1 and Example 1 is that the Chinese herbal medicine extract is not embedded in nanoliposomes; Comparative Example 2

[0020] The difference between Comparative Example 2 and Example 1 is that the substances used to prepare nanoliposomes in Comparative Example 2 are egg yolk lecithin and cholesterol; Test Example 1: Clinical efficacy study

[0021] Using the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial)" as diagnostic criteria, patients with eczema were randomly divided into an experimental group and a control group, with 30 cases in each group. The two groups showed no statistically significant differences in age, gender, or disease duration (P > 0.05), indicating comparability. The drug was administered once every three days for a seven-day course, with a maximum treatment course of three courses. The efficacy of the treatment was statistically analyzed. A follow-up visit was conducted one month after the completion of treatment to assess recurrence.

[0022] Standard of care: Cured: Symptoms disappeared, eczema subsided, and there was no itching: Significantly effective: Eczema subsides by 65% or more, with no itching; Effective: Eczema subsides by 25-65%, with slight itching; Ineffective: No change before and after treatment, or the change is not obvious; Dosage: 100 mL / d / person; Control group: Ebastine was taken according to the instructions; Blank control group: no treatment; The experiment lasted for 10 days. After the experiment was completed, the patients' recovery was observed, and the results are shown in Table 1. After the treatment was completed, the recurrence of cured patients in the experimental and control groups was investigated to observe whether the patients had relapsed. The investigation was conducted once in the third, sixth, and ninth weeks after the completion of the experiment, and the results are shown in Table 1.

[0023] Table 1 Clinical efficacy of the Chinese medicine composition of the present invention

[0024] It can be seen from Table 1 above that the Chinese medicine composition of the present invention prepared in Example 1 has a better therapeutic effect on eczema, while the effect of Comparative Example 1 is the worst.

[0025] Comparing Examples 1-3, it can be seen that the different ratios of the various Chinese medicine components will affect the therapeutic effect on eczema. The possible reasons are: 1. The antibacterial synergistic threshold effect of Phellodendron chinense and Coptis chinensis: The mass ratios of Phellodendron chinense and Coptis chinensis in the examples are different, and the antibacterial activity is different. Exceeding the optimal synergistic ratio will lead to a weakening of the π-π stacking effect of the isoquinoline alkaloids; 2. The dynamic balance of immune regulation of Rehmannia glutinosa and Licorice: When the two are not in a suitable ratio range, the immune regulation effect will be reduced; 3. The lipid barrier repair synergy of Aesculus fragrans and Poria cocos: The aescin and Poria cocos polysaccharide provided by Aesculus fragrans have a higher activity of epidermal ceramide synthase at a certain mass ratio, but the imbalance of the ratio of the two leads to a decrease in repair efficiency; Comparison of Example 1 with Comparative Example 1 shows that the therapeutic effect of the Chinese medicine component on eczema after the medicinal material extract is encapsulated in nanoliposomes is significantly improved. The possible reasons are: 1. Enhanced transdermal absorption: Liposomes increase the transdermal permeability coefficient of hydrophilic components, such as berberine, thereby increasing its epidermal retention; 2. Sustained and controlled release properties: The phase transition temperature of the lipid bilayer allows the drug to be slowly released at skin temperature to maintain an effective concentration; 3. Protection of component stability: For example, the degradation rate of oxidation-sensitive components in Phellodendron chinense, such as berberine ketone, is reduced during storage at room temperature after lipid encapsulation; Comparing Example 1 with Comparative Example 2, it can be seen that the materials used to prepare nanoliposomes are different, and the effects of the prepared traditional Chinese medicine composition on the treatment of eczema are also different. The possible mechanisms are: 1. Membrane structure adaptability: soybean lecithin contains a high proportion of unsaturated fatty acids, and the thickness of the liposome membrane formed with β-sitosterol is reduced, which is more conducive to the transmembrane diffusion of lipophilic components; 2. Surface charge optimization: the soybean lecithin / β-sitosterol system has stronger electrostatic repulsion than egg yolk lecithin / cholesterol, and the particle size distribution is reduced, which reduces the encapsulation rate caused by storage aggregation; 3. Targeted release characteristics: β-sitosterol can specifically bind to the skin stratum corneum lipids, thereby improving the targeted release rate of liposomes in the epidermis; Clinical case excerpts:

[0026] Case 1: Mr. Tang, male, 30 years old, had skin papules with exudate and scattered blisters on his abdomen and legs for 2 years. The condition worsened for 1 week. After 5 days of applying topical medication, the itching was relieved and the skin lesions were reduced. After 10 days of medication, the skin scabs formed. After 8 weeks of medication, the condition was cured, the rash subsided, the skin exudate decreased, and the itching improved.

[0027] Case 2: Xue, a 30-year-old female, was 10 weeks pregnant and had multiple abdominal rashes for two months, accompanied by itching and exudation. After one week of topical medication, the itching disappeared and the exudation decreased. Four weeks later, the rash was completely healed. A follow-up visit one year later showed no recurrence.

[0028] Case 3: Ms. Liu, a 30-year-old female, presented with red erosive lesions and exudate over the areola, painful and cracked nipples, and skin flushing for a year. The symptoms worsened over a week and resolved after eight weeks of medication. No recurrence was observed during a one-year follow-up.

[0029] Case 4: Zhou, male, 30 years old, had scattered erythema, papules, scratches and scales in the cubital fossa, and the skin epidermis in this area was rough. He recovered after 12 weeks of medication and had no recurrence during one year of follow-up.

[0030] Finally, it should be noted that the above embodiments are used to illustrate the technical solutions of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. Use of a traditional Chinese medicine composition containing horse chestnut, raw rehmannia, liquorice, coix seed, phellodendron, coptis root, atractylodes, schizonepeta, smilax glabra and angelica dahurica in preparing a product for treating eczema.

2. The use according to claim 1, characterized in that The traditional Chinese medicine composition is mainly prepared from the following raw materials, calculated by weight: 10-15 parts of Aesculus fragrans leaves, 10-15 parts of Rehmannia root, 5-10 parts of Licorice root, 3-6 parts of Coix seeds, 2-5 parts of Phellodendron amurense, 1-3 parts of Coptis chinensis, 2-5 parts of Atractylodes lancea, 3-6 parts of Schizonepeta tenuifolia, 1-5 parts of Poria cocos, and 3-6 parts of Angelica dahurica.

3. The use according to claim 1, characterized in that The traditional Chinese medicine composition is mainly prepared from the following raw materials, calculated by weight: 10-13 parts of horsetail leaves, 10-14 parts of raw rehmannia root, 5-8 parts of liquorice, 3-6 parts of coix seeds, 2-4 parts of phellodendron, 1-3 parts of coptis chinensis, 2-5 parts of atractylodes, 3-5 parts of schizonepeta tenuifolia, 1-4 parts of poria, and 3-5 parts of angelica dahurica.

4. The use according to claim 3, characterized in that The Chinese medicine composition is mainly prepared from the following raw materials, calculated by weight: 11 parts of Aesculus fragrans leaves, 13 parts of Rehmannia root, 6 parts of Licorice root, 4 parts of Coix seeds, 2 parts of Phellodendron amurense, 2 parts of Coptis chinensis, 4 parts of Atractylodes lancea, 3 parts of Schizonepeta tenuifolia, 3 parts of Poria cocos, and 4 parts of Angelica dahurica.

5. The Chinese medicine composition according to any one of claims 1 to 4, characterized in that The preparation method is: Step 1: Take each amount of the Chinese medicinal components, grind them through a 40-60 mesh sieve, continue to add water to extract for 1-1.5 hours, decoct for 2-3 hours, and filter with 300-400 mesh gauze to obtain the residue and the primary liquid; Step 2: continue to boil the residue obtained in step 1 at 50-60 degrees Celsius for 1-2 hours, and filter through 300-400 mesh gauze to obtain a secondary medicinal solution; Step 3: The primary and secondary drug solutions obtained in Steps 1 and 2 are combined, embedded in nanoliposomes, and further concentrated at 60-80 degrees Celsius and a negative pressure of 0.08-0.11 MPa to obtain an extract concentrate; Step 4: Dry the extract obtained in the above step 3 at 60-80 degrees Celsius and a negative pressure of 0.08-0.11 MPa to obtain a dry paste, grind it, and add appropriate amounts of auxiliary materials and adhesives to granulate.

6. The Chinese medicine composition according to claim 5, characterized in that: The water-to-material ratio in step 1 is (10-20) ml:1 g, and the water-to-material ratio in step 2 is (10-15) ml:1 g.

7. The Chinese medicine composition according to claim 5, characterized in that The preparation steps of step 3 nanoliposome embedding are as follows: S1. Weigh a certain amount of soybean lecithin and β-sitosterol and dissolve them in anhydrous ethanol at a mass ratio of 7-10:

1. Ultrasonicate and evaporate in a preheated rotary evaporator under vacuum to remove the ethanol. S2. After the organic solvent evaporates, a thin film appears on the bottle wall. Continue rotary evaporation and the film collapses. S3. Combine the extracted primary and secondary drug solutions and pour them into an evaporating flask. After 30-40 minutes, the film will completely embed the active ingredients of the drug solution. Pour out the liquid and continue ultrasonication for 10-20 minutes.

8. The Chinese medicine composition according to claim 5, characterized in that: The auxiliary material is dextrin, and its usage amount is the same as the weight of the crushed dry paste.

9. The Chinese medicine composition according to claim 5, characterized in that: The adhesive is ethanol with a volume fraction of 70-95%.

10. Use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in preparing a product for treating eczema.

Images