Medicinal and edible homologous compound preparation as well as preparation method and application thereof
Through the combination of medicinal and food homologous compound preparations, the medicinal and food homologous compound preparations prepared with the characteristics of traditional Chinese medicine has solved the problem of major side effects of drugs in the treatment of chronic bronchitis, and achieved the effects of warming the lungs and relieving phlegm, relieving cough and relieving asthma, which is suitable for alleviating the symptoms of chronic bronchitis.
Patent Information
- Application Number
- CN202510603642.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-12
- Publication Date
- 2025-08-19
AI Technical Summary
In the prior art, therapeutic drugs for chronic bronchitis have problems with long-term use of major side effects, drug resistance and adverse reactions, and lack effective natural therapy.
The preparation method is to use loquat leaves, green quartz, rosen fruit, ginger, lily, citrus, tangerine peel, guarana extract, cloves, natural menthol and erythritol. By combining the medicinal properties of different components, the preparation method is wet granulation to prepare the preparation of medicine and food homologous compound.
This preparation warms the lungs and eliminates phlegm, relieves cough and relieves asthma, nourishes yin and moistens dryness, promotes salivation and relieves pharynx, reduces reversal and stops vomiting, effectively relieves the symptoms of cough, phlegm, dry throat and other symptoms of chronic bronchitis, and is easy to operate and suitable for industrial production.
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Figure CN120501834A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of medicine-food compound preparations, and in particular to a medicine-food compound preparation, a preparation method thereof, and uses thereof. Background Art
[0002] Chronic bronchitis is a common respiratory disease characterized by chronic, nonspecific inflammation of the trachea, bronchial mucosa, and surrounding tissues. Symptoms include cough, sputum production, dry throat, and wheezing, often occurring for three months each year for two or more consecutive years. It is most common in autumn and winter, when temperatures drop sharply, and is particularly aggravated by colds.
[0003] Chronic bronchitis is primarily caused by factors such as long-term smoking, air pollution, and occupational exposure to dust and chemicals. Firstly, long-term smoking is one of the main causes of chronic bronchitis. Harmful substances in tobacco irritate the bronchial mucosa, leading to inflammation and increased mucus secretion, which in turn causes symptoms such as coughing, sputum production, and difficulty breathing. Furthermore, air pollutants such as sulfur dioxide and nitrogen oxides can damage the bronchi and trigger chronic inflammation. Secondly, occupational exposure to dust and chemicals is also a significant risk factor for chronic bronchitis. For example, people with long-term dust exposure, such as miners and construction workers, and those with long-term exposure to harmful chemicals, such as chemical plant workers, are all at high risk of developing chronic bronchitis. Furthermore, personal factors such as immune dysfunction, airway hyperresponsiveness (a condition in which the airways are more sensitive and prone to coughing or wheezing in response to cold air or smoke), autonomic dysfunction, aging, and genetic factors may all contribute to the development and progression of chronic bronchitis.
[0004] To treat chronic bronchitis, doctors typically prescribe medications tailored to the condition. Commonly used medications include antibiotics (such as amoxicillin and cefaclor), bronchodilators (such as albuterol and ipratropium bromide), and glucocorticoids (such as budesonide and fluticasone). These medications can relieve symptoms, reduce inflammation, and improve patients' quality of life.
[0005] Western medicine typically treats chronic bronchitis with antibiotics, antimicrobial drugs, or hormones. Long-term use can lead to tolerance, increased dosage, or even loss of effectiveness. It can also cause numerous adverse reactions and damage the body.
[0006] The concept of "medicine and food have the same origin" offers a natural approach that generally carries a lower risk of side effects than medications, allowing people to maintain their health through dietary adjustments in their daily lives. Summary of the Invention
[0007] In view of this, the present invention aims to propose a medicine-food compound preparation, so as to provide a product suitable for relieving chronic bronchitis.
[0008] To achieve the above object, the technical solution of the present invention is achieved as follows:
[0009] A medicinal and edible compound preparation, the components of which include loquat leaves, green kumquat, momordica grosvenori, ginger, lily, polygonatum, tangerine peel, guarana extract, cloves, natural menthol, and erythritol.
[0010] Furthermore, the components of the medicine-food compound preparation include, by weight percentage, 20% to 30% loquat leaves, 10% to 20% kumquat, 8% to 15% momordica grosvenori, 8% to 15% ginger, 6% to 10% lily, 6% to 10% polygonatum, 3% to 7% tangerine peel, 3% to 7% guarana extract, 1% to 5% cloves, 0.5% to 2% natural menthol, and the rest is erythritol.
[0011] Compared with the prior art, the present invention has the following advantages:
[0012] The components of the medicinal and edible compound preparation of the present invention include loquat leaves, green kumquat, momordica grosvenori, ginger, lily, polygonatum, tangerine peel, guarana extract, cloves, natural menthol, and erythritol. The combination of loquat leaves and green kumquat, where loquat leaves have a slightly cold nature and green kumquat has a warm nature, can reduce the drug's bias, making the compound preparation more mild in nature and enhancing its cough and asthma-relieving efficacy.
[0013] At the same time, the medicinal and edible compound preparation of the present invention also utilizes the combination of Momordica grosvenori, Lilium bulbs, and Polygonatum odoratum, all of which enter the lung meridian. Their combined effects significantly enhance the compound preparation's yin-nourishing, moistening, and relieving throat pain. Furthermore, ginger, tangerine peel, and cloves in the compound preparation enter both the lung and stomach meridians. Their combined use enables the medicinal and edible compound preparation of the present invention to warm the lungs and resolve phlegm while also relieving nausea and vomiting.
[0014] Therefore, the entire medicine-food compound preparation of the present invention has the effects of warming the lungs and resolving phlegm, relieving cough and asthma, nourishing yin and moistening dryness, promoting the production of body fluid and relieving sore throat, and relieving adverse reactions and vomiting, which is beneficial for alleviating clinical symptoms of chronic bronchitis such as cough, sputum, dry throat, and wheezing, thereby providing a product suitable for alleviating the symptoms of chronic bronchitis.
[0015] At the same time, the present invention also provides a preparation method of the above-mentioned medicine-food compound preparation, which comprises:
[0016] Grind and sieve the loquat leaves, the lily, the polygonatum, the tangerine peel, the monk fruit, the ginger, the guarana extract, the clove, the kumquat, the erythritol, and the natural menthol respectively;
[0017] Premixing the sieved loquat leaves, lily bulbs, polygonatum odoratum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, kumquat and erythritol, and then adding ethanol to prepare wet granules;
[0018] The wet granules are dried to obtain dry granules, and the dry granules are mixed with the sieved natural menthol to obtain the medicine-food composite preparation.
[0019] Furthermore, the loquat leaves, the lily, the polygonatum, the tangerine peel, the momordica grosvenori, the ginger, the guarana extract, the cloves and the kumquat are sieved through an 80-mesh sieve; and / or,
[0020] The erythritol is sieved through a 40-mesh sieve; and / or,
[0021] The natural menthol was sieved through a 60-mesh sieve.
[0022] Furthermore, the premixing time is between 8 minutes and 15 minutes; and / or,
[0023] The total mixing time is between 18 minutes and 25 minutes.
[0024] Furthermore, the concentration of the ethanol is between 70% and 95%.
[0025] Furthermore, the drying temperature of the wet granules is between 35°C and 55°C.
[0026] The preparation method of the medicine-food compound preparation of the present invention adopts wet granulation, which has a simple process, is easy to operate, and is conducive to industrial production.
[0027] In addition, the present invention also proposes a use of the above-mentioned medicine-food compound preparation, which is used to relieve the symptoms of chronic bronchitis.
[0028] Furthermore, the symptoms of chronic bronchitis include at least one of cough, sputum and dry throat. BRIEF DESCRIPTION OF THE DRAWINGS
[0029] The accompanying drawings, which constitute part of the present invention, are provided to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are provided to explain the present invention and do not constitute an undue limitation of the present invention. In the accompanying drawings:
[0030] Figure 1 The present invention is a flow chart of the preparation method of the medicine-food compound preparation. DETAILED DESCRIPTION
[0031] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.
[0032] If no specific conditions are specified in the present invention, the process may be carried out in accordance with conventional conditions or the conditions recommended by the manufacturer of the equipment used. If the manufacturer of the reagents or instruments used is not specified, conventional products purchased from the market may be used. If no specific conditions are specified for the technical means or process methods involved, the process may be carried out in accordance with existing methods and procedures in the relevant field.
[0033] In Traditional Chinese Medicine (TCM), prevention is better than cure. Recommendations include quitting smoking, strengthening one's constitution, preventing colds, maintaining good indoor ventilation, eating small, frequent meals, drinking plenty of water, consuming more fresh fruits and vegetables, avoiding spicy foods, combining meat and vegetables, maintaining a regular sleep and rest schedule, exercising moderately, and regulating one's mood. Furthermore, the concept of "medicine and food sharing the same origin" is a crucial tool for preventing illness before it occurs. In TCM theory, this concept is closely linked to the "Four Qi and Five Flavors" (the cold, hot, warm, and cool properties of food, as well as the sour, bitter, sweet, pungent, and salty flavors). TCM believes that by properly combining the properties and flavors of food, the body's yin and yang balance can be balanced, achieving health and wellness. This concept of medicine and food sharing the same origin is widely used in dietary therapy. For example, ginger, known for its diaphoretic and anti-inflammatory properties, is often used to treat the early stages of a cold; hawthorn fruit aids digestion and is often used to alleviate food stagnation. These foods can be selected and combined in daily life based on individual constitution and seasonal changes. They offer therapeutic and health-enhancing benefits without the side effects of medication.
[0034] Therefore, in view of the above introduction, this embodiment relates to a compound preparation of medicine and food, so as to provide a product suitable for relieving chronic bronchitis.
[0035] In terms of overall design, the components of the medicine-food compound preparation of this embodiment include loquat leaves, green kumquat, momordica grosvenori, ginger, lily, polygonatum, tangerine peel, guarana extract, cloves, natural menthol, and erythritol.
[0036] Specifically, the loquat leaves in the above components are bitter, slightly cold in nature, and enter the lung and stomach meridians. They contain amygdalin and hydrocyanic acid produced by hydrolysis, which can relieve symptoms such as cough and wheezing. They also contain ethyl acetate, which can improve the infection symptoms of Staphylococcus aureus, Pneumococcus, and Shigella flexneri, achieving a certain antibacterial effect. In addition, the triterpene acids contained in loquat leaves have a certain improvement effect on airway inflammation of chronic bronchitis.
[0037] The green kumquat in the ingredients contains vitamin C, vitamin A, vitamin P, aromatic oil, carotenoids and other substances, which have the effects of regulating qi and relieving depression, resolving phlegm and relieving cough, strengthening the spleen and stimulating appetite.
[0038] The component, Momordica grosvenori, is the fruit of the Cucurbitaceae plant Momordica grosvenori. Momordica grosvenori is sweet, cool in nature, and enters the lung and spleen meridians. It has the effect of clearing heat and moistening the lungs, can relieve the dryness and heat of the lungs, moisturize the respiratory mucosa, promote the dilution and discharge of sputum, and can be used to treat chronic pharyngitis, bronchitis and other respiratory diseases.
[0039] The ginger in the ingredient is spicy and slightly warm in nature. It enters the lung, spleen, and stomach meridians. It has the effects of dispelling cold, warming the middle and stopping vomiting, warming the lungs and relieving cough. It is often used to treat colds, stomach cold vomiting, cold phlegm cough and other symptoms.
[0040] The lily in the component is the dried fleshy phosphorus leaf of the lily plant of the Liliaceae family. It tastes sweet, is cold in nature, and enters the heart and lung meridians. It has the effects of nourishing yin and moistening the lungs, relieving cough, clearing the heart and calming the mind. It is often used to treat yin deficiency and dry cough, cough with blood due to fatigue, restlessness and palpitations, insomnia and dreaminess, and trance.
[0041] The component Polygonatum odoratum is the dried rhizome of the Liliaceae plant Polygonatum odoratum. It tastes sweet, is neutral in nature, enters the lung and stomach meridians, and has the effects of nourishing yin and moistening dryness, relieving restlessness and quenching thirst. It is often used to treat lung and stomach yin damage, dry heat cough, dry throat and thirst, internal heat and thirst, etc.
[0042] The tangerine peel in the component is the outer red part of the mature peel of the tangerine plant of the Rutaceae family. It tastes pungent and bitter, and is warm in nature. It enters the lung and spleen meridians and has the effects of dispelling cold, drying dampness, promoting qi, and eliminating phlegm. In addition, the geraniol, linalool, naringin and other ingredients contained in tangerine peel have antibacterial and anti-inflammatory effects. It is often used to treat cough with excessive phlegm, food stagnation and alcohol damage, vomiting, nausea, and fullness in the body.
[0043] The guarana extract in the ingredients is extracted from guarana seeds. It is rich in polyphenols and has strong antioxidant capacity. It can neutralize free radicals, reduce cell damage, and enhance the body's metabolism.
[0044] The cloves in the ingredients are the dried flower buds of the Myrtaceae plant clove. They are pungent in taste and warm in nature. They enter the spleen, stomach, lung and kidney meridians. They have the effects of warming the middle and relieving adverse reactions, warming the kidneys and assisting yang. They are often used to treat spleen and stomach deficiency and cold, hiccups and vomiting, anorexia, vomiting and diarrhea, cold pain in the heart and abdomen, kidney deficiency and impotence, etc.
[0045] The natural menthol in the ingredient is extracted from the leaves and stems of mint. It is a terpene organic compound that has the effects of dispersing wind-heat, clearing the head, relieving sore throat and rash, and soothing the liver and promoting qi.
[0046] Erythritol in the components is a sweetener with low energy and good taste. In this embodiment, it is used to improve the taste of the preparation and make it easier to take.
[0047] Based on the above introduction to each component, the medicine-food compound preparation of this embodiment is used in combination by using loquat leaves and kumquat, taking advantage of the fact that loquat leaves are slightly cold and kumquat is warm, which can reduce the bias of the medicine and make the medicinal properties of the compound preparation milder, while also enhancing its cough and asthma-relieving effect.
[0048] At the same time, the present invention also utilizes the combination of Momordica grosvenori, Lilium bulbs, and Polygonatum odoratum, all of which enter the lung meridian. Their combined effects significantly enhance the compound's yin-nourishing, moistening, and sore throat-relieving effects. Furthermore, ginger, tangerine peel, and cloves in the compound not only enter the lung meridian but also the stomach meridian. Their combined use enables the present invention to warm the lungs and resolve phlegm while also relieving nausea and vomiting.
[0049] Therefore, the entire medicine-food compound preparation of this embodiment has the effects of warming the lungs and resolving phlegm, relieving cough and asthma, nourishing yin and moistening dryness, promoting fluid production and relieving sore throat, and relieving adverse reactions and vomiting, which is beneficial for alleviating clinical symptoms of chronic bronchitis such as cough, sputum, dry throat, and wheezing, thereby providing a product suitable for alleviating the symptoms of chronic bronchitis.
[0050] It is worth noting that, based on the above overall component composition, further, in the specific implementation, the components of the medicine-food compound preparation of this embodiment can be, by weight percentage, for example, 20% to 30% loquat leaves, 10%-20% green kumquat, 8% to 15% momordica grosvenori, 8% to 15% ginger, 6% to 10% lily, 6% to 10% polygonatum, 3% to 7% tangerine peel, 3% to 7% guarana extract, 1% to 5% cloves, 0.5% to 2% natural menthol, and the rest is erythritol.
[0051] In this embodiment, based on the above introduction to the components of the medicinal and edible compound preparation, in specific implementation, the above medicinal and edible compound preparation is a rational preparation method, combined with Figure 1 As shown, the specific steps include:
[0052] Step S1: Grind and sieve loquat leaves, lily bulbs, polygonatum odoratum, tangerine peel, monk fruit, ginger, guarana extract, cloves, kumquat, erythritol, and natural menthol respectively.
[0053] In the above step S1, loquat leaves, lily, polygonatum, tangerine peel, monk fruit, ginger, guarana extract, cloves and green kumquat are sieved. As a preferred embodiment, for example, loquat leaves, lily, polygonatum, tangerine peel, monk fruit, ginger, guarana extract, cloves and green kumquat can be sieved using an 80-mesh sieve.
[0054] At the same time, in the above step S1, erythritol is sieved. As a preferred embodiment, for example, erythritol can be sieved through a 40-mesh sieve.
[0055] In addition, in the above step S1, the natural menthol is sieved. As a preferred embodiment, for example, the natural menthol can be sieved through a 60-mesh sieve.
[0056] Step S2: pre-mixing the sieved loquat leaves, lily bulbs, polygonatum odoratum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, kumquat, and erythritol, and then adding ethanol to prepare wet granules;
[0057] The pre-mixing time in step S2 may preferably be between 8 minutes and 15 minutes.
[0058] Meanwhile, the concentration of ethanol used in the above step S2 may preferably be, for example, between 75% and 95%. The use of ethanol as a binder for wet granulation is beneficial for subsequent drying and removal of the binder.
[0059] Step S3: drying the wet granules to obtain dry granules, and mixing the dry granules with the sieved natural menthol to obtain a medicine-food compound preparation.
[0060] The drying temperature of the wet particles in step S3 is preferably, for example, between 35°C and 55°C.
[0061] Meanwhile, the total mixing time in the above step S3 may preferably be between 18 minutes and 25 minutes, for example.
[0062] According to the above introduction, the preparation method of the medicinal and edible compound preparation of this embodiment adopts wet granulation, which has a simple process, is easy to operate, and is conducive to industrial production.
[0063] In addition, this embodiment also relates to the use of the above-mentioned medicine-food compound preparation. Specifically, the medicine-food compound preparation of this embodiment is used to relieve the symptoms of chronic bronchitis.
[0064] The above-mentioned chronic bronchitis symptoms may be, for example, at least one of cough, sputum production and dry throat.
[0065] Therefore, the medicinal and edible compound prepared in this embodiment can provide a product suitable for relieving chronic bronchitis.
[0066] Based on the above introduction, with respect to the medicinal and edible compound preparation of the present invention, its preparation method and use, further, in the specific implementation, reference may be made to the following preparation examples.
[0067] Example 1
[0068] This Example 1 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0069] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0070] S2. Premix 20 g loquat leaves, 10 g lily bulbs, 10 g polygonatum, 7 g tangerine peel, 10 g momordica grosvenori, 10 g ginger, 7 g guarana extract, 5 g cloves, 15 g kumquat, and 4 g erythritol, and then add ethanol to prepare wet granules.
[0071] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0072] Example 2
[0073] This Example 2 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0074] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0075] S2. Pre-mix 30 g of loquat leaves, 8 g of lily bulbs, 8 g of polygonatum, 5 g of tangerine peel, 10 g of momordica grosvenori, 10 g of ginger, 5 g of guarana extract, 3 g of cloves, 15 g of kumquat, and 4 g of erythritol after sieving, and then add ethanol to prepare wet granules;
[0076] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0077] Example 3
[0078] This Example 3 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0079] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0080] S2. Premix 25 g loquat leaves, 10 g lily bulbs, 8 g polygonatum, 5 g tangerine peel, 13 g momordica grosvenori, 10 g ginger, 5 g guarana extract, 3 g cloves, 15 g kumquat, and 4 g erythritol, and then add ethanol to prepare wet granules.
[0081] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0082] Example 4
[0083] This Example 4 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0084] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0085] S2. Premix 23 g of sieved loquat leaves, 8 g of lily bulbs, 10 g of polygonatum, 4 g of tangerine peel, 13 g of momordica grosvenori, 13 g of ginger, 5 g of guarana extract, 3 g of cloves, 15 g of kumquat, and 4 g of erythritol, and then add ethanol to prepare wet granules.
[0086] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0087] Example 5
[0088] This Example 5 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0089] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0090] S2. Premix 23 g of sieved loquat leaves, 8 g of lily bulbs, 8 g of polygonatum, 5 g of tangerine peel, 13 g of momordica grosvenori, 13 g of ginger, 5 g of guarana extract, 4 g of cloves, 15 g of kumquat, and 4 g of erythritol, and then add ethanol to prepare wet granules.
[0091] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0092] Example 6
[0093] This Example 6 is to prepare the above-mentioned medicinal and edible compound preparation, and the specific preparation steps are as follows:
[0094] S1. Grind loquat leaves, lily, polygonatum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, and green kumquat respectively, and sieve through an 80-mesh sieve for later use; grind erythritol and sieve through a 40-mesh sieve for later use; grind natural menthol and sieve through a 60-mesh sieve for later use.
[0095] S2. Premix 28 g loquat leaves, 7 g lily bulbs, 7 g polygonatum, 5 g tangerine peel, 15 g momordica grosvenori, 11 g ginger, 5 g guarana extract, 4 g cloves, 12 g kumquat, and 4 g erythritol, and add ethanol to prepare wet granules.
[0096] S3. Dry the wet granules to obtain dry granules, and then mix the dry granules with 2 g of sieved natural menthol to obtain a medicine-food compound preparation.
[0097] Verification Example
[0098] This validation example is to verify the alleviating effect of the medicinal and edible compound preparation on the symptoms of chronic bronchitis by observing the changes in symptoms, vital capacity, and serum interleukin-4 inflammatory factor levels after taking the medicinal and edible compound preparation prepared in Example 1. The specific implementation steps for the above validation process are as follows:
[0099] 1. Trial population
[0100] The clinical symptoms of chronic bronchitis were cough, sputum and dry throat.
[0101] 2. Crowd Grouping
[0102] A total of 120 selected trial subjects were randomly divided into two groups, namely the compound preparation group and the control group, with 60 people in each group.
[0103] 3. Trial method
[0104] Compound preparation group: oral compound preparation for 21 consecutive days;
[0105] Control group: Oral administration of cefradine and ambroxol for 21 consecutive days.
[0106] 4. Observation indicators
[0107] 4.1 Symptom assessment: The subjective feelings of the trial takers before and after the trial, such as cough, sputum, and dry throat symptoms, were recorded and scored according to their severity (no symptoms = 0 points, mild = 2 points, moderate = 4 points, severe = 6 points). The changes in symptom scores and the proportion of improvement were analyzed.
[0108] 4.2 Vital capacity: Compare the vital capacity values of the compound preparation group and the control group before and after the trial.
[0109] 4.3 Levels of interleukin-4 inflammatory factor in serum: Compare the interleukin-4 values before and after the trial in the compound preparation group and the control group.
[0110] 5. Verify the results
[0111] 5.1 Symptom changes in the two groups before and after the trial, including the changes in the score corresponding to the cough symptom are shown in Table 1 below, the changes in the score corresponding to the sputum symptom are shown in Table 2 below, and the changes in the score corresponding to the dry throat symptom are shown in Table 3 below.
[0112] Table 1
[0113]
[0114] Note: #Compared with the first day of trial, P < 0.05.
[0115] As can be seen from the data in Table 1, the cough symptoms of the trial group and the control group were significantly improved, with significant differences, and the compound preparation group was better than the control group (P < 0.05).
[0116] Table 2
[0117]
[0118] Note: #Compared with the first day of trial, P < 0.05.
[0119] As can be seen from the data in Table 2, the symptoms of expectoration in both the compound preparation group and the control group were significantly improved, with significant differences (P < 0.05).
[0120] Table 3
[0121]
[0122] Note: #Compared with the first day of trial, P < 0.05.
[0123] As can be seen from the data in Table 3, the dry throat symptoms of the trial group and the control group were significantly improved, with significant differences, and the compound preparation group was better than the control group (P < 0.05).
[0124] 5.2 The changes in vital capacity of the two groups before and after the trial are shown in Table 4 below.
[0125] Table 4
[0126]
[0127]
[0128] Note: #Compared with the first day of trial, P < 0.05.
[0129] As can be seen from the data in Table 4, the dry throat symptoms of the trial group in both the compound preparation group and the control group were significantly improved, with significant differences, and the compound preparation group was better than the control group (P < 0.05).
[0130] 5.3 The changes in the levels of interleukin-4 inflammatory factor in the serum of the two groups of people before and after the trial are shown in Table 5 below.
[0131] Table 5
[0132]
[0133] Note: #Compared with the first day of trial, P < 0.05.
[0134] As can be seen from the data in Table 5, there was no significant difference in the interleukin-4 inflammatory factor levels between the compound preparation group and the control group before treatment (P>0.05); after treatment, the interleukin-4 inflammatory factor levels decreased significantly, and the difference was significant (P<0.05).
[0135] During the validation process, the control group, taking cefradine, demonstrated rapid and reliable bactericidal effects against drug-resistant Staphylococcus aureus and various other broad-spectrum antibiotic-resistant bacilli, making it suitable for respiratory infections such as bronchitis. Meanwhile, the control group, taking ambroxol, a mucolytic drug, is indicated for both acute and chronic bronchitis. Taking both drugs together can improve symptoms of cough, sputum production, and dry throat in patients with chronic bronchitis. Therefore, the combined use of both drugs served as the control group for this validation study.
[0136] Through the above results, it can be seen from the data in Tables 1, 2 and 3 that the symptoms of cough, sputum and dry throat in the chronic bronchitis group taking the compound preparation were significantly improved on the 21st day compared with the symptoms on the 1st day, and the effect was better than that of the control group taking cefradine and ambroxol. Therefore, it can be seen that taking the compound preparation can effectively relieve the symptoms of cough, sputum and dry throat in the chronic bronchitis group.
[0137] At the same time, it can be seen from the data in Tables 4 and 5 that the lung capacity of the chronic bronchitis group taking the compound preparation on the 21st day was significantly increased compared with that on the 1st day, and the level of interleukin-4 inflammatory factor in the serum was significantly decreased, indicating that the lung condition and inflammation of the trial group were alleviated.
[0138] In summary, the ingredients of the food-drug compound preparation of the present invention work synergistically to warm the lungs and resolve phlegm, relieve cough and asthma, nourish yin and moisten dryness, promote the production of body fluids and relieve sore throat, and relieve adverse reactions and vomiting, thereby relieving clinical symptoms of chronic bronchitis such as cough, sputum, and dry throat, thereby providing a food-drug compound preparation suitable for relieving symptoms of chronic bronchitis. Figure 1 It can be seen that the preparation method of the medicine-food compound preparation of the present invention has a simple process, is easy to operate, and is conducive to industrial production.
[0139] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.
Claims
1. A medicinal and edible compound preparation, characterized by: The components of the medicine-food compound preparation include loquat leaves, green kumquat, momordica grosvenori, ginger, lily, polygonatum, tangerine peel, guarana extract, cloves, natural menthol and erythritol.
2. The medicinal and edible compound preparation according to claim 1, characterized in that: The components of the medicine-food compound preparation include, by weight percentage, 20% to 30% loquat leaves, 10% to 20% kumquat, 8% to 15% momordica grosvenori, 8% to 15% ginger, 6% to 10% lily, 6% to 10% polygonatum, 3% to 7% tangerine peel, 3% to 7% guarana extract, 1% to 5% cloves, 0.5% to 2% natural menthol, and the rest is erythritol.
3. The method for preparing the medicinal and edible compound preparation according to claim 1 or 2, wherein: The preparation method comprises: Grind and sieve the loquat leaves, the lily, the polygonatum, the tangerine peel, the monk fruit, the ginger, the guarana extract, the clove, the kumquat, the erythritol, and the natural menthol respectively; Premixing the sieved loquat leaves, lily bulbs, polygonatum odoratum, tangerine peel, momordica grosvenori, ginger, guarana extract, cloves, kumquat and erythritol, and then adding ethanol to prepare wet granules; The wet granules are dried to obtain dry granules, and the dry granules are mixed with the sieved natural menthol to obtain the medicine-food composite preparation.
4. The method for preparing the medicine-food compound preparation according to claim 3, characterized in that: The loquat leaves, the lily, the polygonatum, the tangerine peel, the momordica grosvenori, the ginger, the guarana extract, the cloves and the kumquat are sieved through an 80-mesh sieve; and / or, The erythritol is sieved through a 40-mesh sieve; and / or, The natural menthol was sieved through a 60-mesh sieve.
5. The method for preparing the medicine-food compound preparation according to claim 3, characterized in that: The premixing time is between 8 minutes and 15 minutes; and / or, The total mixing time is between 18 minutes and 25 minutes.
6. The method for preparing the medicine-food compound preparation according to claim 3, characterized in that: The concentration of the ethanol is between 70% and 95%.
7. The method for preparing the medicine-food compound preparation according to claim 3, characterized in that: The drying temperature of the wet granules is between 35°C and 55°C.
8. The use of the medicinal and edible compound preparation according to claim 1 or 2, characterized in that: The medicine-food composite preparation is used for relieving the symptoms of chronic bronchitis.
9. The use of the medicinal and edible compound preparation according to claim 8, characterized in that: The chronic bronchitis symptoms include at least one of cough, sputum production and dry throat.