Detection control method of sample analyzer and sample analyzer controller

Abstract

The invention relates to a detection control method of a sample analyzer and a sample analyzer controller. The sample analyzer can provide a single-person test and a multi-person test, can meet the requirements of the single-person test and the multi-person test on one sample analyzer, and obtains a first test and a target second test processed by the liquid separation needle in an action sequence during mixed test of the single-person test and the multi-person test; sample test modes of the first test and the second test are different and are one of single-person test and multi-person test; the first liquid adding duration of the sample test mode of the first test is longer than the second liquid adding duration of the sample test mode of the second test; and the liquid separation needle is controlled to execute the liquid adding operation sequence within the first liquid adding duration for the first test and the target second test in the action sequence, so that the test efficiency during single-person test and multi-person test mixed test is improved.

Description

[0001] This application is a divisional application submitted to the China Patent Office on February 19, 2024, with application number 202410183787.3, and the invention name is "Detection control method of sample analyzer and sample analyzer controller", all of which are incorporated by reference into this application. Technical Field

[0002] The present application relates to the fields of medical detection technology and sample analyzer technology, and in particular to a detection control method of a sample analyzer and a sample analyzer controller. Background Art

[0003] Reagent storage area Reagent storage area Sample analyzer is an instrument used to detect and analyze samples. In related technologies, sample analyzers, such as coagulation analyzers used for coagulation analysis, mostly use bottled reagents (multi-person reagents). The reagent volume of bottled reagents is sufficient for multiple samples, but in some application scenarios, the number of test items is small, resulting in the bottled reagents cannot be used up within the validity period after opening, resulting in reagent waste. Summary of the Invention

[0004] Based on this, it is necessary to provide a detection control method and device for a sample analyzer, a sample analyzer controller, a computer-readable storage medium, and a computer program product that can improve test efficiency in order to address the above technical problems.

[0005] In a first aspect, the present application provides a detection control method for a sample analyzer. The method comprises:

[0006] Obtaining a sample test mode for a first test of a sample analyzer; the sample test modes provided by the sample analyzer include single-person test and multi-person test;

[0007] determining a target reagent storage area according to the sample test mode;

[0008] In response to the liquid adding instruction of the first test, controlling the dispensing needle of the sample analyzer to move to above the target reagent container in the target reagent storage area;

[0009] The dispensing needle is controlled to be inserted into the target reagent container in a needle insertion manner corresponding to the sample testing mode, and the reagent is sucked from the target reagent container.

[0010] In a second aspect, the present application also provides a detection control device for a sample analyzer. The device comprises:

[0011] The detection mode determination module is used to obtain a sample test mode for a first test of the sample analyzer; the sample test modes provided by the sample analyzer include single-person test and multi-person test.

[0012] The storage area determination module is used to determine the target reagent storage area according to the sample test mode.

[0013] The control module is used to control the dispensing needle of the sample analyzer to move to the top of the target reagent container in the target reagent storage area in response to the liquid addition instruction of the first test; control the dispensing needle to lower the needle into the target reagent container in the needle lowering method corresponding to the sample test mode, and to absorb the reagent from the target reagent container.

[0014] In a third aspect, the present application further provides a sample analyzer controller. The computer device includes a memory and a processor, the memory stores a computer program, and the processor implements the detection control method of the sample analyzer of each of the above embodiments when executing the computer program.

[0015] In a fourth aspect, the present application further provides a computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, implements the detection control method of the sample analyzer of each of the above embodiments.

[0016] In a fifth aspect, the present application further provides a computer program product, which includes a computer program that, when executed by a processor, implements the detection control method of the sample analyzer according to each of the above embodiments.

[0017] The detection control method, device, sample analyzer controller, storage medium and computer program product of the above-mentioned sample analyzer, the sample analyzer can provide single-person testing and multi-person testing, and can realize single-person testing and multi-person testing needs on a sample analyzer, allowing medical structures to flexibly select single-person reagents and multi-person reagents for testing according to the sample volume and / or the number of test items, adapt to different application scenarios, and avoid reagent waste. Furthermore, for different sample testing modes, a matching needle insertion method is set, and then the dispensing needle is controlled to insert the needle into the target reagent container in the needle insertion method corresponding to the sample testing mode, and the reagent is drawn from the target reagent container for sample analysis and testing. This method takes into account the different storage volumes and storage forms of single-person reagents and multi-person reagents, so that the dispensing needle can draw reagents from the target reagent container in an orderly and efficient manner, thereby improving the reagent addition efficiency and testing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 FIG. 1 is an application environment diagram of a detection control method of a sample analyzer in one embodiment;

[0019] Figure 2 1 is a flow chart of a detection control method of a sample analyzer in one embodiment;

[0020] Figure 3 is a schematic diagram of a graphical user interface of a sample analyzer in one embodiment;

[0021] Figure 4 is a schematic diagram of the planar layout of a sample analyzer in one embodiment;

[0022] Figure 5 Schematic diagram of the action sequence of the dispensing needle movement cycle in one embodiment;

[0023] Figure 6 1 is a flow chart of a detection control method of a sample analyzer in one embodiment;

[0024] Figure 7 for Figure 5 The schematic diagram of the dispensing needle movement cycle after extension is shown;

[0025] Figure 8 is a structural block diagram of a detection control device of a sample analyzer in one embodiment;

[0026] Figure 9 FIG. 1 is a diagram showing the internal structure of a computer device in one embodiment. DETAILED DESCRIPTION

[0027] In order to make the purpose, technical solutions and advantages of this application more clear, the following further describes this application in detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not intended to limit this application.

[0028] The sample analyzer is applied to the field of medical inspection, and its function is to detect the sample to be tested, wherein the sample to be tested can be blood, urine or body fluid, etc. In the present application, the sample analyzer can be a coagulation analyzer, a blood analyzer, a urine analyzer or a body fluid analyzer. In the related art, the sample analyzer includes a sample placement area and a reagent bottle storage area (a multi-person reagent storage area), wherein the sample placement area is used to store a plurality of test tubes (also called sample tubes), and the reagent bottle storage area is used to store a plurality of reagent bottles, each of which can store different or the same type of reagents. In general, the reagent storage capacity of the reagent bottle is large, which can meet the use of multiple people, such as the use of dozens of test samples, and is suitable for scenes with a large sample size (for example, large hospitals or large testing institutions). However, for application scenarios with a small sample size, since the reagents stored in the reagent bottle have a use-by-date limit, especially after the reagent bottle is unsealed, once the reagent exceeds the expiration date, it cannot be continued to be used, resulting in a waste of reagents. To address these technical issues, related technologies have introduced reagent card strips, which are used to store reagents for a single test, eliminating the need for large reagent bottles. A single test is considered a single test, as opposed to a multiple test. This refers to a packaged, fixed quantity of reagents sufficient for testing a single sample (for a single person). However, it is understood that a sample analyzer with only reagent bottles or reagent card strips cannot fully accommodate all application scenarios.

[0029] Based on this, the sample analyzer of this application is configured to be compatible with both single-person and multi-person tests, allowing medical institutions to flexibly select the test method to adapt to different application scenarios (using single-person tests when there are few test items and using multi-person tests when there are many test items) to avoid reagent waste. On this basis, this application provides a detection control method for a sample analyzer to solve the problem of how to effectively perform detection control.

[0030] A detection and control method for a sample analyzer can be applied to Figure 1 In the application environment shown in FIG. In particular, the sample analyzer of this application takes a coagulation analyzer as an example. Figure 1 As shown, the control unit 100 of the sample analyzer is connected to the sampling unit 110, the reagent adding unit 130, the incubation unit 120, the detection unit 140, and the cup discarding unit 150, respectively, to implement the control of each of the above units. In one detection example, the control unit 100 controls the sampling unit 110 to add the sample to the detection cup, controls the reagent adding unit 130 to add the diluent to the detection cup, shakes the sample and diluent in the detection cup, and then sends the sample to the incubation unit 120 for incubation. After the incubation is completed, the reagent adding unit is controlled to add the reagent to the detection cup, and the detection cup is sent to the detection unit 140 for detection. After the detection is completed, the cup discarding unit 150 is controlled to discard the detection cup.

[0031] In the above example, more structures may be included, such as a cup feeding mechanism, a cup gripping hand, a cleaning device, etc. For example, the cup feeding mechanism is used to provide a test cup for the sample analyzer, and the test cup is, for example, an optical test cup; the cup gripping hand is used to transfer the test cup to different areas of the sample analyzer to cooperate with different units; the cleaning device is used to clean the sampling unit and the reagent adding unit.

[0032] In some embodiments, the sampling unit and the reagent adding unit can be integrated into a dispensing unit, which can realize sample adding and reagent adding operations.

[0033] In one embodiment, Figure 2 As shown, a detection control method of a sample analyzer is provided, and the method is applied to Figure 1 The control unit in the example is used to illustrate the process, which includes the following steps:

[0034] Step 202 : Acquire a sample test mode for a first test of a sample analyzer; the sample test mode of the sample analyzer includes single-person test and multi-person test.

[0035] A test is a test item performed on a sample by a sample analyzer. The test items of a sample analyzer vary depending on the type of sample analyzer. Taking a coagulation analyzer as an example, test items may include the PT (Prothrombin time) test, the APTT (Activated Partial Thromboplastin Time) test, the TT (Thrombin time) test, the FIB (Fibrinogen) test, the FDP (Fibrin / Fibrinogen Degradation Products) test, the DD (D-Dimer) test, and the AT-III (Antithrombin III) test.

[0036] The sample analyzer used in the detection and control method of the sample analyzer of the present application can implement two sample testing modes, namely single-person testing and multi-person testing.

[0037] A single-dose test is used to test a sample using a single dose of reagent. A multi-dose test is used to test a sample using multiple doses of reagent. It is understood that a single sample may undergo multiple tests simultaneously. For example, a single sample may undergo seven tests simultaneously: PT, APTT, TT, FIB, FDP, DD, and AT-III, also known as the seven coagulation tests. PT, APTT, TT, and FIB are the four routine coagulation tests. The four routine coagulation tests are the most commonly used clinically for initial coagulation screening, used for preliminary diagnosis of coagulation disorders. The test volume is relatively high, so multi-dose reagents can be used. The two fibrinolysis and antithrombin III tests, among the seven coagulation tests, are used for further diagnosis of bleeding disorders, to assess fibrinolysis and anticoagulant function. The test volume in medical institutions is relatively low, so single-dose reagents can be used. When the four coagulation tests are tested together with the two fibrinolysis or antithrombin III tests, multi-dose reagents and single-dose reagents can be used, respectively. Of course, when the overall sample size of a medical institution is small, single-person reagents can be used.

[0038] It is worth noting that the terms "multiple-sample test" and "single-sample test" in this application refer to tests in a specific setting. As mentioned above, for a single sample, the four coagulation tests (PT, APTT, TT, and FIB) can correspond to multiple-sample tests, while the two fibrinolysis tests (FDP, DD, AT-III, or antithrombin III) can correspond to single-sample tests.

[0039] Specifically, how to choose between single-sample testing and multi-sample testing can be achieved through the sample application or sample registration process of the graphical user interface. For example, Figure 3 For the graphical user interface of sample analyzer, it can be displayed on the display screen of sample analyzer, or it can be displayed on the computer equipment connected with the sample analyzer communication, for providing user with human-computer interaction mode.This graphical user interface comprises loading channel 210 and sample result display interface 220, wherein loading channel 210 comprises single portion reagent card strip channel bitmap 211 and multiple sample bitmaps 212, single portion reagent card strip channel bitmap 211 corresponds to single portion reagent card strip, and sample bitmap 212 corresponds to sample tube.When carrying out sample application or sample registration, sample bitmap 212 can be clicked, select to use single portion reagent or multi-person portion reagent in the test configuration interface (not shown) that pops up.It is understandable that the graphical user interface of sample analyzer can also include the bitmap (not shown) of multi-person portion reagent bottle.

[0040] In one embodiment, how to select single-person detection and multi-person detection can also determine the sample detection mode of the first test by automatic recognition. When the sampling unit is used to collect the sample to be tested from the sample tube on one or more sample racks, the control unit of the sample analyzer obtains the sample rack information of each sample rack by scanning a code (bar code or QR code) or image recognition. Each sample rack can be used to carry one sample tube or multiple sample tubes. Wherein, the sample rack information can include the bar code, QR code, number or sample rack type of the sample rack, and the sample rack type includes a sample loading rack and a reagent card strip loading rack. The sample loading rack is used to carry one sample tube or multiple sample tubes, and the reagent card strip loading rack is used to carry a single-person reagent card strip and 1 sample tube, with the position of the multiplexed sample placement area. After the control unit obtains the sample rack information of each sample rack, the control unit obtains the sample detection mode based on the sample rack information. For example, when the sample rack type is a reagent card strip loading rack, the sample tube on the reagent card strip loading rack is automatically associated with the single-person reagent card strip, that is, the test performed by the sample to be tested in the sample tube all adopts single-person reagent.

[0041] In one embodiment, when the sampling unit is used to collect samples to be tested from sample tubes on a plurality of sample racks, the control unit of the sample analyzer may obtain test information of the samples, where the test information includes a sample test mode.

[0042] Step 204: Determine a target reagent storage area according to the sample test mode.

[0043] Among them, the sample analyzer is provided with a multi-person reagent storage area and a single-person reagent storage area. The multi-person reagent storage area is used to store reagent bottles to perform multi-person sample analysis tests. The single-person reagent storage area includes at least one reagent card strip storage channel to store reagent card strips, wherein the reagent card strip includes at least one reagent storage position to store single-person reagent to perform single-person sample analysis tests.

[0044] The layout diagram of a sample analyzer according to an embodiment is shown in FIG. Figure 4 As shown, it includes a single-portion reagent storage area and a multi-portion reagent storage area. Among them, the multi-portion reagent storage area can be used to store reagent bottles to perform multi-portion sample analysis tests. The multi-portion reagent storage area includes multiple reagent containers (such as reagent bottles) for storing multi-portion reagents. Multi-portion reagents are reagents that can be used multiple times. Each reagent bottle contains a large amount of reagent and can be used for multiple tests.

[0045] The type of reagent stored in the reagent container is related to the test items of the sample analyzer. Taking a coagulation analyzer as an example, the reagent bottles in the multi-person reagent storage area are used to store at least one of the following reagents: PT (Prothrombin time) reagent, APTT (Activated Partial Thromboplastin Time) reagent, TT (Thrombin time) reagent, FIB (Fibrinogen) reagent, FDP (Fibrin / Fibrinogen Degradation Products) reagent, DD (D-Dimer) reagent, and AT-III (Antithrombin III) reagent.

[0046] Optionally, the multi-person reagent storage area can also be used to store common reagent bottles, which are used to store buffer solutions, cleaning solutions and / or diluents; wherein the common reagent bottles can be arranged in an array.

[0047] The single-dose reagent storage area includes at least one reagent card storage channel for storing reagent card strips. The reagent card strips contain at least one reagent storage location for storing single-dose reagents for performing single-dose sample analysis tests. Single-dose reagents are disposable reagents; each reagent pack contains only the reagents required for a single test and is used only for a single test. The type of single-dose reagent depends on the test item being tested by the sample analyzer.

[0048] In one embodiment, the reagent cartridge can be used to store buffers, wash solutions, and / or diluents.

[0049] Taking the coagulation analyzer as an example, the reagent card strip can include four reagent storage positions, which can be used to store PT reagent, APTT reagent, TT reagent and FIB reagent respectively, or only store DP (Fibrin / Fibrinogen Degradation Products, fibrin (original) degradation products) reagent, DD (D-Dimer, D-dimer) reagent, AT-III (antithrombin III) reagent or one or more, so that the reagent card strips can be used in combination.

[0050] Step 206 : In response to the liquid adding instruction of the first test, control the dispensing needle of the sample analyzer to move to above the target reagent container in the target reagent storage area.

[0051] As mentioned above, the sample analyzer is provided with a multi-portion reagent storage area corresponding to a multi-portion test, and a single-portion reagent storage area corresponding to a single-portion test. The multi-portion reagent storage area and the single-portion reagent storage area are both provided for storing diluents and cleaning fluids. Therefore, in the single-portion test and the liquid addition operation in the multi-portion test, it is necessary to obtain the corresponding reagents from the corresponding reagent storage area. In this application, reagents include diluents (buffers), cleaning fluids and detection reagents. Adding liquid is also adding reagents, including operations such as adding diluents, adding detection reagents and using cleaning fluid to clean the inner wall of the dispensing needle. In the following situations, unless otherwise specified, adding reagents generally refers to adding detection reagents. Wherein the detection reagent refers to the reagent used for the test, such as the PT reagent used for the PT test.

[0052] The liquid addition operation for the first test depends on the type of dispensing needle. For example, if the dispensing needle is a sample dispensing needle, the liquid addition operation for the first test can be at least one of adding a diluent and aspirating a cleaning fluid for inner wall cleaning. For another example, if the dispensing needle is used for both sample and reagent addition, the liquid addition operation for the first test can be at least one of adding a diluent, aspirating a cleaning fluid for inner wall cleaning, and adding a detection reagent. Among them, the operation of adding diluent and adding detection reagent of the dispensing needle includes moving from the dispensing needle origin to above the target reagent container in the target reagent storage area, inserting the needle into the target reagent container in the needle-inserting method corresponding to the sample test mode, and sucking the diluent or detection reagent from the target reagent container, lifting the needle and moving to the liquid adding position to discharge the diluent or detection reagent and add it to the detection cup; the operation of absorbing cleaning liquid for inner wall cleaning of the dispensing needle includes moving from the dispensing needle origin to above the target reagent container in the target reagent storage area, inserting the needle into the target reagent container in the needle-inserting method corresponding to the sample test mode, and sucking the cleaning liquid from the target reagent container, lifting the needle and moving to the dispensing needle origin (cleaning device), and discharging the cleaning liquid before the next dispensing needle action.

[0053] Taking the addition of liquid as an example, in some embodiments, the sample analyzer is provided with a sampling unit and a reagent adding unit. The control unit controls the sampling unit to add the sample of the first test into the detection cup. The control unit then controls the reagent adding unit to move to the top of the target reagent container in the target reagent storage area to perform the reagent adding operation. The sampling unit is usually a sampling needle, and the reagent adding unit is usually a reagent adding needle. That is, in this embodiment, the sampling needle and the reagent adding needle respectively perform the sampling and reagent adding operations. The liquid separating needle in this embodiment is the reagent adding needle of the reagent adding unit.

[0054] In some embodiments, the sample analyzer is provided with a dispensing unit. The control unit controls the dispensing unit to add the sample for the first test into the test cup. The control unit then controls the dispensing unit to move to above the target reagent container in the target reagent storage area to perform the reagent addition operation. That is, in this embodiment, the dispensing unit is used to perform both sample dispensing and reagent addition and dispensing operations.

[0055] Wherein, after determining the target reagent storage area, the control unit can determine the target reagent container according to the test item type of the first test. Generally speaking, the target reagent container stores the reagent required for the first test. In certain embodiments, when the target reagent storage area stores a plurality of target reagent containers suitable for the first test, the control unit can also determine the target reagent container according to the priority of the reagent bottle. For example, according to the unsealing date, production date, etc. of the reagent, the target reagent container is determined in combination with the type of the first test. For example, if the target reagent storage area stores two bottles of A reagent required for the first test, the reagent bottle with the earliest unsealing time in these two bottles of A reagent can be determined as the target reagent container, so as to give priority to the reagent unsealed first.

[0056] Step 208 : Control the dispensing needle to insert into the target reagent container in a needle insertion manner corresponding to the sample testing mode, and draw reagent from the target reagent container.

[0057] Among them, due to the different storage volumes and storage forms of single-portion reagents and multi-portion reagents, if the needle insertion method is not distinguished, and the same needle insertion method is used to obtain the reagents for both, there may be problems such as the inability to obtain the reagents or low efficiency in obtaining the reagents. For example, multi-portion reagents are packaged in bottles. During the multi-portion test process, the amount of reagent in the reagent bottle changes with consumption. When inserting the needle, it is often necessary to detect the liquid level to determine the position to add the reagent in order to accurately absorb the required amount of reagent. At the same time, when the liquid amount in the reagent bottle is insufficient, it can be detected by liquid level detection and switched to another reagent bottle storing the same reagent. Single-portion reagents are for single use, and the amount of reagent in the reagent card strip is relatively fixed. If the liquid level detection method is also used when inserting the needle, the efficiency of reagent acquisition is affected.

[0058] Therefore, this embodiment takes into account the different storage volumes and storage formats of single-dose and multi-dose reagents, and sets matching needle insertion methods for different sample testing modes. The dispensing needle is then controlled to insert the needle into the target reagent container using the insertion method corresponding to the sample testing mode and draw the reagent from the target reagent container. This allows the dispensing needle to draw reagent from the target reagent container in an orderly and efficient manner.

[0059] According to the liquid adding instruction, diluent, reagent, or cleaning liquid can be drawn from the target reagent container.

[0060] Taking reagent addition as an example, after the reagent is dispensed into the test cup, subsequent sample analysis and testing are performed according to the test process of the first test. For example, if the first test is a coagulation test, the sample analyzer's gripper can be controlled to mix the sample and reagent and transfer them to the test position for testing.

[0061] The detection control method of the above-mentioned sample analyzer, the sample analyzer can provide single-person testing and multi-person testing, and can realize single-person testing and multi-person testing needs on a sample analyzer, allowing medical institutions to flexibly select single-person reagents and multi-person reagents for testing according to the sample volume and / or the number of test items, adapt to different application scenarios, and avoid reagent waste. Furthermore, for different sample testing modes, matching needle insertion methods are set, and then the dispensing needle is controlled to insert the needle into the target reagent container in the needle insertion method corresponding to the sample testing mode, and the reagent is drawn from the target reagent container for sample analysis and testing. This method takes into account the different storage volumes and storage forms of single-person reagents and multi-person reagents, so that the dispensing needle can draw reagents from the target reagent container in an orderly and efficient manner, thereby improving the reagent addition efficiency and testing efficiency.

[0062] In another embodiment, the reagent storage area of the sample analyzer includes a multi-person reagent storage area, and the multi-person reagent storage area is used to store reagent bottles. Figure 4 As shown, the multi-person reagent storage area is used to store commonly used reagent bottles, and multiple reagent bottles can be arranged in an array.

[0063] When the sample test mode is a multi-person test, controlling the dispensing needle to lower the needle into the target reagent container in a needle-lowering manner corresponding to the sample test mode and drawing reagent from the target reagent container includes: controlling the dispensing needle to move downward and detecting the liquid level of the target reagent bottle during the movement; after detecting the liquid level, controlling the dispensing needle to draw reagent from the target reagent bottle.

[0064] For example, the dispensing needle may be a capacitive dispensing needle or a resistive dispensing needle. When the needle contacts the liquid surface, the capacitance or resistance changes. The controller of the sample analyzer detects the liquid surface upon receiving the capacitance or resistance change.

[0065] Specifically, the reagents for multiple people are packaged in bottles, and the bottles are in an open state during testing. Therefore, a needle insertion method based on liquid level detection is used when aspirating the reagents for multiple people testing.

[0066] Taking the addition of reagents as an example, the dispensing needle is controlled to move to the top of the target reagent bottle in the multi-dose reagent storage area, the needle is lowered to absorb the reagent in the form of liquid level detection, and then moved to the reagent adding position in the air (not the actual hole position, but a virtual position. Taking the coagulation analyzer as an example, it is located above the middle of the two holes on the right side of the magnetic beads), the reagent is dispensed into the test cup and then moved to the cleaning device for cleaning. After dispensing the reagent, the cup gripper mixes the sample and reagent and transfers them to the test position for testing.

[0067] If the sample and reagent additions share a dispensing needle, the sample and reagent addition process for the first test can be as follows: the cup gripper moves from the origin to the cup tray, grabs a new test cup, and transfers it to the sample loading position. Simultaneously with the cup gripper's activation, the dispensing needle, after being cleaned by the cleaning device, moves to the top of the multi-dose reagent area and lowers the needle based on liquid level detection. After the liquid level detection signal is triggered, the diluent is aspirated, the needle is moved to the top of the sample area, lowered based on liquid level detection, and aspirated after the liquid level detection signal is triggered. The needle moves to the sample loading position and dispenses the diluent and sample mixture into the test cup. The cup gripper grabs the test cup, mixes it, and then transfers it to the incubation area for incubation. After the incubation is completed, the cup grabber transfers the test cup to the aerial reagent adding position. At the same time as the cup grabber is started, the dispensing needle is cleaned in the cleaning device and moves to the top of the multi-dose reagent area. The needle absorbs the reagent in the form of liquid level detection and then moves to the aerial reagent adding position. The reagent is dispensed into the test cup and then moved to the cleaning device for cleaning. After dispensing the reagent, the cup grabber mixes the sample and reagent and transfers them to the detection position for testing.

[0068] In this embodiment, taking into account the changes in the amount of reagents in the reagent bottles in the multi-person reagent storage area and the characteristics of the storage form of the reagent bottles, the liquid level detection method is used to insert the needle when sampling from multiple people's reagents, which can improve the success rate of extracting reagents from the target reagent bottles.

[0069] In another embodiment, the reagent storage area of the sample analyzer includes a single-agent reagent storage area, and the single-agent reagent storage area includes a reagent card strip; the target reagent container is a target reagent card strip. Figure 4 As shown, the single-serve reagent storage area can be set in the sample placement area, that is, the sample placement area and the single-serve reagent storage area can share an area.

[0070] The reagent card includes at least one reagent storage location for storing a single dose of reagent. The reagent in the reagent card is for a single person's use, and the amount of reagent perfused in each card is fixed. Typically, single-dose reagents are in the form of sealed film card strips. The diaphragm contains metal material, and the metal diaphragm interferes with the liquid level detection signal, making it impossible to insert the needle using the liquid level detection method. Since the single-dose reagent card is designed for single use, the amount of reagent perfused in each card is fixed. Therefore, when aspirating the reagent, the needle is inserted by moving to a fixed reagent aspiration position.

[0071] Specifically, when the sample test mode is a single-person test, controlling the dispensing needle to insert the needle into the target reagent container in the insertion method corresponding to the sample test mode and drawing the reagent from the target reagent container includes: controlling the dispensing needle to move downward to a fixed position, and during the movement, the dispensing needle pierces the sealing film of the target reagent card strip and draws the reagent in the target reagent card strip at the fixed position.

[0072] Specifically, the dispensing needle may be driven by a stepper motor, and controlling the dispensing needle to move downward to a fixed position specifically involves controlling the stepper motor by the sample analyzer to drive the dispensing needle to move a fixed number of steps to reach the fixed position.

[0073] Specifically, the dispensing needle is controlled to move to the top of the single-dose reagent card strip, vertically downward to pierce the sealing film of the reagent card strip, and then moves to a fixed position to absorb the reagent and dispense it into the detection cup.

[0074] If the sample and reagent additions share a single dispensing needle, the sample and reagent addition operations for the first test can be as follows: the cup gripper moves from the origin to the cup tray, grabs a new test cup, and transfers it to the sample loading position. Simultaneously with the cup gripper's activation, the dispensing needle, after being cleaned by the cleaning device, moves to the top of the single-dose reagent strip, vertically downwards pierces the seal of the reagent strip, and then moves to a fixed position to draw the diluent. The needle then moves to the sample loading position and dispenses the diluent and sample mixture into the test cup. The cup gripper grabs the test cup, mixes it, and then transfers it to the incubation area for incubation. After incubation, the cup gripper transfers the test cup to the aerial reagent loading position. Simultaneously with the cup gripper's activation, the dispensing needle, after being cleaned by the cleaning device, moves to the top of the single-dose reagent strip, vertically downwards pierces the seal of the reagent strip, and then moves to a fixed position to draw the reagent. The needle then moves to the aerial reagent loading position, dispenses the reagent into the test cup, and then moves to the cleaning device for cleaning. After dispensing the reagent, the cup gripper mixes the sample and reagent and transfers it to the test position for testing.

[0075] In this embodiment, combined with the characteristics of the fixed reagent volume in the reagent card strip in the single-person reagent area and the packaging method of the reagent card strip, when sampling from the single-person reagent, the method of directly lowering the needle to a fixed position is adopted, which allows the dispensing needle to efficiently absorb the reagent from the target reagent container, thereby improving the reagent addition efficiency and testing efficiency.

[0076] In another embodiment, the controlling the dispensing needle to move downward to a fixed position, wherein the dispensing needle pierces the sealing film of the target reagent card strip during the movement and absorbs the reagent in the target reagent card strip at the fixed position, includes: controlling the dispensing needle to move downward to pierce the sealing film at the first position of the target reagent card strip; controlling the dispensing needle to move to the top of the target reagent card strip, and then moving downward to the fixed position, wherein the dispensing needle pierces the sealing film at the second position of the target reagent card strip during the movement and absorbs the target reagent in the target reagent card strip at the fixed position.

[0077] In this embodiment, in the needle insertion method for a single-dose reagent card strip, the reagent card strip needs to be punctured twice, and the positions of the two punctures are different. Among them, before the first puncture, the reagent card strip is first punctured once to allow the reagent in the reagent card strip to be exposed to the atmosphere, preventing the negative pressure generated during the packaging of the reagent card strip or other reasons from affecting the accuracy of reagent extraction. When the reagent needle is drawing the reagent, the reagent card strip is punctured a second time, and the position of the second puncture does not overlap with the position of the first puncture. This prevents the plastic layer of the diaphragm from tightly fitting with the puncture section of the dispensing needle during the reagent drawing process. After the reagent is drawn, negative pressure is generated in the reagent card strip cavity, affecting the accuracy of reagent drawing.

[0078] In one embodiment, the reagent storage area of the sample analyzer includes a multi-sample reagent storage area corresponding to multiple-sample tests and a single-sample reagent storage area corresponding to single-sample tests. The multi-sample reagent storage area has a first distance from the origin of the dispensing needle, and the single-sample reagent storage area has a second distance from the origin of the dispensing needle.

[0079] Among them, the origin of the dispensing needle is the initial position of the dispensing needle, that is, the starting point of the dispensing needle for the dispensing operation. In a specific embodiment, the origin position can be above the cleaning device. When the dispensing needle processes single-portion tests and multi-portion tests, it is necessary to draw reagents from the corresponding reagent storage area. The single-portion reagent storage area and the multi-portion reagent storage area are set at different positions, so the first distance between the multi-portion reagent storage area and the dispensing needle origin, and the second distance between the single-portion reagent storage area and the dispensing needle origin are different.

[0080] The distance between the dispensing needle's origin and the different reagent storage areas will affect the duration of reagent addition. For example, if the first distance is greater than the second distance, the dispensing needle may take longer to add reagents to multiple samples than to add reagents to a single sample. Conversely, if the second distance is greater than the first distance, the dispensing needle may take longer to add reagents to a single sample than to add reagents to multiple samples.

[0081] It is understood that the reagent addition time is affected not only by the distance between the reagent storage area and the origin of the dispensing needle, but also by the needle insertion method, etc. In actual application, the liquid addition time can be determined based on multiple influencing factors, such as distance and needle insertion method.

[0082] In one embodiment, Figure 4 As shown, in the sample analyzer, the multi-person reagent storage area is set at a position close to the origin of the dispensing needle, and the single-person reagent storage area is set at a position relatively far away from the origin of the dispensing needle, resulting in a first distance between the multi-person reagent storage area and the origin of the dispensing needle being smaller than a second distance between the single-person reagent storage area and the origin of the dispensing needle.

[0083] When the needle insertion method has little effect on the time of adding reagents, this difference in distance will make the time for the dispensing needle to add a single dose of reagent longer than the time for the dispensing needle to add multiple doses of reagents.

[0084] The inventors of the present application have found that in the field of sample analysis, there is often a demand for mixed testing of single-person tests and multi-person tests. Taking the coagulation analyzer as an example, the four coagulation items are the most commonly used tests for the initial screening of coagulation function in clinical practice, which are used for the preliminary diagnosis of coagulation disorders. The detection volume is relatively large and can be applied to multi-person reagent bottles. The two fibrinolysis items and antithrombin III detection in the seven coagulation items are used for further diagnosis of hemorrhagic diseases and are used to detect fibrinolytic function and anticoagulant function. The detection volume in medical institutions is relatively small and can be applied to single-person reagent strips. When the four coagulation items are tested together with the two fibrinolysis items or antithrombin III, multi-person reagent bottles and single-person reagent strips are required.

[0085] However, since the liquid adding time for the single-person test is different from the liquid adding time for the multi-person test, test abnormalities will occur during mixed testing.

[0086] Specifically, the control methods and test cycles for single- and multi-study tests differ, necessitating separate control flows for single- and multi-study testing. When the sample analyzer is performing all single- or multi-study tests, the corresponding control flow can be invoked. However, when the sample analyzer performs mixed single and multi-study tests, testing efficiency can be low due to the different liquid addition times for single and multi-study tests.

[0087] Sample analysis tests often involve multiple reagent additions. For example, after adding a quantitative diluent or buffer to the test sample and diluting the sample in the test cup, the test cup is typically moved to an incubation position for incubation. After incubation is complete, reagents are added for sample analysis. In other words, for Test A, after the first reagent addition is completed, a certain amount of time must be waited before the second reagent addition can be performed. At this point, the dispensing needle can continue to add samples, diluents, or reagents for Test B after cleaning.

[0088] For ease of explanation, a movement of the dispensing needle from leaving the dispensing needle origin to returning to the dispensing needle origin is usually called a dispensing needle movement segment. Within a dispensing needle movement cycle, there is a dispensing needle movement sequence consisting of one or more dispensing needle movement segments.

[0089] The dispensing needle motion segment is specifically a liquid addition operation sequence, used to complete a liquid addition operation. A liquid addition operation sequence can include needle transfer, needle placement, needle removal, needle cleaning, reagent aspiration, and reagent discharge. The liquid addition operation sequence can be used to perform at least one liquid addition operation, such as adding diluent, adding samples, or adding reagents.

[0090] In a dispensing needle action sequence, the dispensing needle can be configured to perform a single sample addition, a single sample addition and a single reagent addition, or a single sample addition and two reagent additions. To balance efficiency and control, each of these operations is treated as a single execution unit, or a single instruction package, which is sent from the sample analyzer's controller to the dispensing needle for execution.

[0091] For example, a sample analyzer with a multi-sample dosing time shorter than a single-sample dosing time. Figure 5 In the shown dispensing needle action sequence, the horizontal axis represents the timing of a test, and the vertical axis represents the action sequence of the dispensing needle in a movement cycle. After the dispensing needle adds samples to multi-person portion 2, while the original dispensing needle movement cycle remains unchanged, because the operation of adding reagent 1 to single-person portion 1 takes a long time, the remaining time in the movement cycle cannot meet the time requirement for adding reagent 2 to multi-person portion 1. Reagent 2 needs to be added to multi-person portion 1 again in the next dispensing needle movement cycle, which causes the reagent addition operation of multi-person portion 1 to be delayed, affecting the test efficiency.

[0092] To address this issue, in this embodiment, a solution is proposed to the problem of detection efficiency being affected by different reagent addition times when two sample test modes with different liquid addition times are mixed.

[0093] Specifically, during mixed testing, the liquid addition time of the two sample test modes is unified according to the longer liquid addition time to extend the movement cycle of the dispensing needle. That is to say, during mixed testing, the liquid addition time of the sample test mode with a shorter liquid addition time is extended, thereby extending the movement cycle of the dispensing needle, so that there is sufficient time to complete the reagent addition operation within the movement cycle.

[0094] In one embodiment, the first liquid addition time length of the sample test mode of the first test is longer than the second liquid addition time length of the sample test mode of the second test. When the first test and the second test are mixed, the detection control method of the sample analyzer is as follows: Figure 6 As shown, it also includes:

[0095] Step 602: Obtain the first test and the target second test processed by the dispensing needle in an action sequence.

[0096] The specific process of adding reagents in the second test is similar to that of the first test. Different needle insertion methods are used according to different sample test modes, which will not be described in detail here.

[0097] As mentioned above, within a dispensing needle movement cycle, the dispensing needle can be set to perform one sample addition operation, or set to perform one sample addition operation + one reagent addition operation, or set to perform one sample addition operation + two reagent addition operations. For a test, there may be incubation, mixing and other processes between the two reagent addition operations, so the two reagent addition operations of a test are usually discontinuous. Therefore, the reagent addition operations of the dispensing needle in the action sequence of the dispensing needle movement cycle are usually for different tests. During mixed testing, the second test that is in the same action sequence as the first test with a longer liquid addition time is affected, and the target second test that is in the same action sequence as the first test is determined.

[0098] Therefore, the target second test here is assigned to all second tests in the same dispensing needle action sequence as the first test, such as all second tests that have been loaded, incubated, or have completed the first reagent addition before the first test starts.

[0099] Step 604, controlling the liquid dispensing to execute the liquid addition operation sequence for the first test and the target second test in an action sequence within the first liquid addition time; the liquid addition operation sequence includes at least one of a diluent addition operation sequence, a reagent addition operation sequence, and a cleaning operation sequence before reagent addition.

[0100] Assuming that the first liquid addition time of the first test is 35 seconds and the second liquid addition time of the second test is 30 seconds, the liquid dispensing is controlled to complete one reagent addition operation for the first test within 35 seconds.

[0101] Since the first liquid-adding time is longer than the second liquid-adding time, the original liquid-adding time of the second test is the second liquid-adding time. By controlling the dispensing needle to add reagents for the target second test within the first liquid-adding time, the liquid-adding time of the target second test is extended, and there is sufficient time to complete a reagent adding operation for the target second test within the movement cycle of the dispensing needle.

[0102] For example, Figure 5 The operation of adding reagent 2 to multiple doses is shown in the following figure after the addition time is extended. Figure 7 As shown in the figure, after the extension, the time for adding the second reagent in the multi-sample reagent 2 is extended to match the time for adding the single-sample reagent 1. Accordingly, the dispensing needle movement cycle is extended. That is, when mixing tests with two different addition times, the longer addition time is used to unify the addition times of the two sample test modes, thereby extending the dispensing needle movement cycle. This ensures sufficient time for the dispensing needle to complete the intended reagent addition operation within the specified movement cycle.

[0103] Among them, the method for extending the duration of a reagent addition operation for the target second test can be to extend an idle cycle based on the second liquid addition duration during the reagent addition process, or to control the speed of the dispensing needle to extend the liquid addition duration.

[0104] It should be noted that the above step identification is not a limitation on the order of steps. For the first test and the second test assigned to a dispensing needle motion cycle (action sequence), taking the addition of reagents as an example, according to the actual situation of the test, if the addition of reagents for the first test comes first, the dispensing needle is first controlled to complete a reagent addition operation for the first test in the first liquid addition time, and then the dispensing needle is controlled to complete a reagent addition operation for the target second test within the first liquid addition time. If the addition of reagents for the second test comes first, the dispensing needle is first controlled to complete a reagent addition operation for the target second test within the first liquid addition time, and then the dispensing needle is controlled to complete a reagent addition operation for the first test in the first liquid addition time.

[0105] In one embodiment, the first test can be a single-person test, and the second test can be a multi-person test, and the first liquid addition time of the single-person test is longer than the second liquid addition time of the multi-person test. During the mixed test, the single-person test and the affected multi-person test assigned to one dispensing needle movement cycle are determined, and the dispensing needle is controlled to complete a reagent addition operation for the single-person test within the first liquid addition time, and the dispensing needle is controlled to complete a reagent addition operation for the affected multi-person test within the first liquid addition time. It can be understood that after all the reagent addition operations for the single-person test are completed, the mixed test is completed. When there is no mixed test, the multi-person test completes a reagent addition operation within the second liquid addition time.

[0106] In one embodiment, the first test can be a multi-person test, and the second test can be a single-person test, and the first liquid addition time of the multi-person test is longer than the second liquid addition time of the single-person test. During the mixed test, the multi-person test and the affected single-person test assigned to one dispensing needle movement cycle are determined, and the dispensing needle is controlled to complete a reagent addition operation for the multi-person test within the first liquid addition time, and the dispensing needle is controlled to complete a reagent addition operation for the affected single-person test within the first liquid addition time. It can be understood that after all the reagent addition operations for the multi-person test are completed, the mixed test is completed. When there is no mixed test, the single-person test completes a reagent addition operation within the second liquid addition time.

[0107] In one embodiment, controlling the dispensing needle to complete a reagent addition operation for the target second test within the first liquid addition time includes: controlling the dispensing needle of the sample analyzer to extend an idle period at any time before, during, or after executing a liquid addition sequence based on the second liquid addition time; the sum of the second liquid addition time and the idle period equals the first liquid addition time. The dispensing needle stops operating during the idle period.

[0108] Specifically, an idle cycle, i.e., an idle cycle, generally refers to a clock cycle that is not used in a processor or computer system. During this idle cycle, the reagent addition operation for the target second test is suspended. Specifically, the idle cycle can be extended at any time before, during, or after a reagent addition operation for the target second test, and the idle cycle plus the duration of the second reagent circumference = the first reagent addition duration. Thus, within this motion cycle of the dispensing needle, the reagent addition duration for the target second test is extended from the second reagent addition duration to the first reagent addition duration.

[0109] Specifically, the control unit obtains a control instruction set for the action sequence within a dispensing needle movement cycle, which includes the action sequence of the dispensing needle. Accordingly, an empty cycle can be added to the reagent addition sequence of the target second test in the control instruction set for the dispensing needle movement cycle.

[0110] In one embodiment, one of the action sequences includes at least one liquid adding operation sequence arranged in time sequence; one of the liquid adding operation sequence includes at least one of a cleaning operation sequence before adding reagents and at most two reagent adding operation sequences.

[0111] In this embodiment, during the movement cycle of the dispensing needle, the dispensing needle control instruction set is issued in the form of a data packet to realize the control of the dispensing needle movement during the movement cycle of the dispensing needle. In this embodiment, it can correspond to the situation where the sample needle and the reagent adding needle are not shared, that is, the sample adding needle and the reagent adding needle are different, then the sample needle control instruction set can be issued to the sample needle respectively to realize the sample adding control. The reagent adding control instruction set is issued to the reagent adding needle to control the reagent adding needle. For the needs of sample analysis, there are usually at least two reagent adding needs for one sample, therefore, an action sequence can include at most two reagent adding operation sequences and a cleaning sequence before adding reagents. Each operation sequence includes the action sequence of the dispensing needle, and the actions of the dispensing needle can include moving the needle, lowering the needle, lifting the needle, cleaning the needle, aspirating the reagent, discharging the reagent, etc.

[0112] In another embodiment, the dispensing needle of the sample analyzer is used to dispense samples and reagents; one of the action sequences includes at least one liquid addition operation sequence arranged in a time sequence; one of the liquid addition operation sequences includes at least one of a cleaning operation sequence before sample addition, a sample addition operation sequence, at most two reagent addition operation sequences, and a cleaning operation sequence before reagent addition.

[0113] In this embodiment, the sample needle and the reagent adding needle share a dispensing needle. In this embodiment, during the movement cycle of the dispensing needle, a dispensing needle control instruction set corresponding to the action sequence within the dispensing needle movement cycle is issued in the form of a data packet to realize the control of the dispensing needle movement during the dispensing needle movement cycle. Among them, one of the action sequences includes at least one liquid adding operation sequence arranged in time sequence; one of the liquid adding operation sequence includes at least one of a cleaning operation sequence before sample addition, a sample addition operation sequence, at most two reagent adding operation sequences, and a cleaning operation sequence before reagent addition. For the dispensing needle, each operation sequence includes the action sequence of the dispensing needle, and the actions of the dispensing needle may include moving the needle, lowering the needle, lifting the needle, cleaning the needle, aspirating the reagent, discharging the reagent, etc.

[0114] By unifying the liquid addition time of the first test and the second test in the mixed test according to the longer liquid addition time, for this dispensing needle cycle, the addition of samples for any test and the combination of adding reagent 1 and adding reagent 2 can be achieved without being restricted by the liquid addition time of the test item.

[0115] The detection control method of the sample analyzer of this embodiment can be applied to a coagulation analyzer. In coagulation analysis, there is a demand for mixed testing of single and multiple people. The control methods and test cycles of single and multiple people are different, so it is necessary to divide them into two sets of control processes, one for single and multiple people. When single and multiple people are tested at the same time, since the test cycles and control instructions of the two modes are different, there are empty cycles in the test process, which reduces the test speed. In order to solve this problem, in this application, when single and multiple people are mixed, an empty cycle is embedded before the multi-person test is started, so that the total test cycle time of multiple people is consistent with the test cycle of a single person. The single-person control process is called for the test items of a single person, and the multi-person control process is called for the test items of multiple people, thereby realizing mixed testing of single and multiple people.

[0116] It should be understood that, although the various steps in the flowcharts involved in the various embodiments described above are displayed in sequence according to the instructions of the arrows, these steps are not necessarily executed in sequence in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and these steps can be executed in other orders. Moreover, at least a portion of the steps in the flowcharts involved in the various embodiments described above can include multiple steps or multiple stages, and these steps or stages are not necessarily executed and completed at the same time, but can be executed at different times, and the execution order of these steps or stages is not necessarily to be carried out in sequence, but can be executed in turn or alternately with other steps or at least a portion of steps or stages in other steps.

[0117] Based on the same inventive concept, embodiments of the present application also provide a detection control device for a sample analyzer for implementing the aforementioned detection control method for a sample analyzer. The solution provided by this device is similar to the solution described in the aforementioned method. Therefore, the specific limitations of the following embodiments of the detection control device for one or more sample analyzers can be found in the aforementioned limitations of the detection control method for a sample analyzer and are not further elaborated here.

[0118] In one embodiment, Figure 8 As shown, a detection control device of a sample analyzer is provided, comprising:

[0119] The detection mode determination module 802 is used to obtain a sample test mode for a first test of the sample analyzer; the sample test modes provided by the sample analyzer include single-person test and multi-person test.

[0120] The storage area determination module 804 is configured to determine a target reagent storage area according to the sample test mode.

[0121] The control module 806 is used to control the dispensing needle of the sample analyzer to move to the top of the target reagent container in the target reagent storage area in response to the liquid addition instruction of the first test, control the dispensing needle to lower the needle into the target reagent container in the needle lowering method corresponding to the sample test mode, and absorb the reagent from the target reagent container.

[0122] In another embodiment, the reagent storage area of the sample analyzer includes a multi-portion reagent storage area, and the multi-portion reagent storage area is used to store reagent bottles; the target reagent container is a target reagent bottle;

[0123] When the sample test mode is multi-person test, the control module is used to control the dispensing needle to move downward and detect the liquid level of the target reagent bottle during the movement; after detecting the liquid level, the control module controls the dispensing needle to absorb the reagent from the target reagent bottle.

[0124] In another embodiment, the reagent storage area of the sample analyzer includes a single-agent reagent storage area; the single-agent reagent storage area includes a reagent card strip; the target reagent container is a target reagent card strip;

[0125] When the sample test mode is single-person test, the control module is used to control the dispensing needle to move downward to a fixed position. During the movement, the dispensing needle pierces the sealing film of the target reagent card strip and absorbs the reagent in the target reagent card strip at the fixed position.

[0126] In another embodiment, the control module is further used to control the dispensing needle to move downward to pierce the sealing film at the first position of the target reagent card strip; control the dispensing needle to move to the top of the target reagent card strip, and then move downward to a fixed position. During the movement, the dispensing needle pierces the sealing film at the second position of the target reagent card strip, and absorbs the reagent in the target reagent card strip at the fixed position.

[0127] In another embodiment, the reagent storage area of the sample analyzer includes a multi-portion reagent storage area corresponding to multi-portion tests, and a single-portion reagent storage area corresponding to single-portion tests; the first distance between the multi-portion reagent storage area and the origin of the dispensing needle and the second distance between the single-portion reagent storage area and the origin of the dispensing needle are different.

[0128] In another embodiment, the first distance is smaller than the second distance.

[0129] In another embodiment, the liquid addition time for the single-serving test is different from the liquid addition time for the multi-serving test.

[0130] In another embodiment, the sample test modes of the first test and the second test are different; the first liquid addition time of the sample test mode of the first test is longer than the second liquid addition time of the sample test mode of the second test, and the control module is also used to obtain the first test and the target second test processed by the liquid addition needle in an action sequence; control the liquid dispensing to execute the liquid addition operation sequence within the first liquid addition time for the first test and the target second test in an action sequence; the liquid addition operation sequence includes at least one of a diluent addition operation sequence, a reagent addition operation sequence, and a cleaning operation sequence before reagent addition.

[0131] In another embodiment, the control module is further used to control the dispensing needle of the sample analyzer to extend the idle period at any time before executing the liquid adding operation sequence, during executing the liquid adding operation sequence, or after executing the liquid adding operation sequence for the second test of the target; the sum of the second liquid adding time and the idle period is the first liquid adding time.

[0132] In another embodiment, one of the action sequences includes at least one liquid adding operation sequence arranged in time sequence; one of the liquid adding operation sequence includes at least one of a cleaning operation sequence before adding reagents and at most two reagent adding operation sequences.

[0133] In another embodiment, the dispensing needle of the sample analyzer is used to dispense samples and reagents; the dispensing needle of the sample analyzer is used to dispense samples and reagents; one of the action sequences includes at least one liquid addition operation sequence arranged in a time sequence; one of the liquid addition operation sequences includes at least one of a cleaning operation sequence before sample addition, a sample addition operation sequence, at most two reagent addition operation sequences, and a cleaning operation sequence before reagent addition.

[0134] In another embodiment, the sample analyzer is a coagulation analyzer.

[0135] Each module in the detection and control device of the sample analyzer described above may be implemented in whole or in part through software, hardware, or a combination thereof. Each module may be embedded in or independent of a processor in a computer device in hardware form, or may be stored in a computer device memory in software form, allowing the processor to call and execute the corresponding operations of each module.

[0136] In one embodiment, a sample analyzer controller is provided. The computer device may be a terminal, and its internal structure diagram may be as follows: Figure 9As shown. The computer device includes a processor, a memory, a communication interface, a display screen and an input device connected via a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The communication interface of the computer device is used to communicate with an external terminal in a wired or wireless manner, and the wireless manner can be achieved through WIFI, a mobile cellular network, NFC (near field communication) or other technologies. When the computer program is executed by the processor, a detection and control method of a sample analyzer is implemented. The display screen of the computer device can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device can be a touch layer covering the display screen, or a button, trackball or touchpad provided on the computer device housing, or an external keyboard, touchpad or mouse, etc.

[0137] Those skilled in the art will understand that Figure 9 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than shown in the figure, or combine certain components, or have a different component arrangement.

[0138] In one embodiment, a computer device is provided, including a memory and a processor. The memory stores a computer program, and the processor implements the detection control method of the sample analyzer of each of the above embodiments when executing the computer program.

[0139] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored. When the computer program is executed by a processor, the detection control method of the sample analyzer of each of the above embodiments is implemented.

[0140] In one embodiment, a computer program product is provided, including a computer program. When the computer program is executed by a processor, the detection control method of the sample analyzer according to each of the above embodiments is implemented.

[0141] Those skilled in the art will appreciate that all or part of the processes in the above-mentioned embodiment methods can be implemented by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, database or other media used in the embodiments provided in this application may include at least one of non-volatile and volatile memory. Non-volatile memory may include read-only memory (ROM), magnetic tape, floppy disk, flash memory, optical memory, high-density embedded non-volatile memory, resistive random access memory (ReRAM), magnetic random access memory (MRAM), ferroelectric random access memory (FRAM), phase change memory (PCM), graphene memory, etc. Volatile memory may include random access memory (RAM) or external cache memory, etc. By way of illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM). The database involved in the various embodiments provided herein may include at least one of a relational database and a non-relational database. Non-relational databases may include, but are not limited to, distributed databases based on blockchains. The processor involved in the various embodiments provided herein may be, but are not limited to, a general-purpose processor, a central processing unit, a graphics processing unit, a digital signal processor, a programmable logic unit, a data processing logic unit based on quantum computing, and the like.

[0142] The technical features of the above embodiments can be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0143] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present application. It should be noted that a person of ordinary skill in the art may make various modifications and improvements without departing from the spirit of the present application, and these modifications and improvements fall within the scope of protection of the present application. Therefore, the scope of protection of the present application shall be determined by the appended claims.

Claims

1. A detection control method for a sample analyzer, characterized in that: The method comprises: When performing a mixed test of a single-person test and a multi-person test, a first test and a target second test processed by a dispensing needle in an action sequence are obtained; the sample test modes of the first test and the second test are different, being one of a single-person test and a multi-person test; and a first liquid addition time length of the sample test mode of the first test is longer than a second liquid addition time length of the sample test mode of the second test; The liquid dispensing is controlled to complete the liquid addition operation sequence within the first liquid addition time for the first test and the target second test in an action sequence.

2. The method according to claim 1, characterized in that The liquid adding operation sequence includes at least one of a diluent adding operation sequence, a reagent adding operation sequence, and a cleaning operation sequence before reagent adding.

3. The method according to claim 2, characterized in that The reagent storage area of the sample analyzer includes a multi-portion reagent storage area corresponding to the multi-portion test and a single-portion reagent storage area corresponding to the single-portion test; the first distance between the multi-portion reagent storage area and the origin of the dispensing needle and the second distance between the single-portion reagent storage area and the origin of the dispensing needle are different.

4. The method according to claim 2, characterized in that The first distance is smaller than the second distance.

5. The method according to any one of claims 2 to 4, characterized in that For the multi-person test and the single-person test, the dispensing needle adopts different needle insertion methods when adding reagents.

6. The method according to claim 1, characterized in that Controlling the liquid dispensing to perform the target second test and completing the liquid addition operation sequence within the first liquid addition time, including: For the second target test, the dispensing needle of the sample analyzer is controlled to extend the idle period at any time before, during, or after the execution of the liquid addition operation sequence based on the second liquid addition time; the sum of the second liquid addition time and the idle period is the first liquid addition time.

7. The method according to claim 1, characterized in that One of the action sequences includes at least one liquid adding operation sequence arranged in time sequence; one of the liquid adding operation sequence includes at least one of a cleaning operation sequence before adding reagents and at most two reagent adding operation sequences.

8. The method according to claim 1, characterized in that The dispensing needle of the sample analyzer is used to dispense samples and reagents; one of the action sequences includes at least one liquid addition operation sequence arranged in a time sequence; one of the liquid addition operation sequences includes at least one of a cleaning operation sequence before sample addition, a sample addition operation sequence, at most two reagent addition operation sequences, and a cleaning operation sequence before reagent addition.

9. The method according to claim 1, characterized in that The sample analyzer is a coagulation analyzer.

10. A sample analyzer controller, comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 9 are implemented.

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