A cell culture shaking device with easy adjustment

Abstract

The application discloses a cell culture shaking device convenient to adjust, and relates to the technical field of cell culture.The cell culture shaking device convenient to adjust comprises a shaking plate, the shaking plate is obliquely arranged in a shell, a plurality of holes are formed in the surface of the shaking plate, a limiting assembly is fixedly connected to the inner side surface of the shaking plate, a driving assembly is fixedly connected to the bottom of the inner side surface of the shell, the side of the driving assembly close to an end cover is in surface spline connection with the limiting assembly, and a clamping assembly is fixedly connected to the inner wall of the hole of the shaking plate.Because the shaking plate is obliquely arranged, the culture bottle not only generates horizontal circular motion in the rotating process, but also generates up-down displacement along the inclined surface of the shaking plate.In the process of revolving around the driving assembly once, the culture bottle will experience a complete rising and falling process, three-dimensional composite oscillation effect is formed, the culture medium and the culture bottle generate complex relative movement, cell and nutrient substance contact can be more efficiently promoted, and gas exchange efficiency is enhanced.

Description

Technical Field

[0001] This invention relates to the field of cell culture technology, and more specifically to a cell culture shaking device that is easy to adjust. Background Technology

[0002] Shaking in cell culture is a crucial step that uses specialized equipment to uniformly mix cell suspensions or culture media within culture flasks, promote gas exchange, and prevent cell aggregation. Its core principle is to utilize mechanical oscillation to move the culture vessel, creating convection and turbulence effects to ensure sufficient contact between cells and nutrients while preventing localized hypoxia or accumulation of metabolic waste. The equipment typically includes temperature and gas regulation systems to simulate the in vivo environment, while clamping components use elastic strips and protective rings to secure the culture flask and prevent cell damage during oscillation. During shaking, parameters such as oscillation frequency, amplitude, and eccentricity can be adjusted to suit the culture needs of adherent or suspension cells. This technique is widely used in biopharmaceuticals, stem cell research, and vaccine production, and is essential for maintaining cell viability and experimental reproducibility.

[0003] In existing technologies, the shaking platform shakes in a fixed direction, and the culture medium can only flow back and forth in one direction, resulting in uneven distribution of the culture medium and poor cell culture effect. Therefore, how to design a technology that can shake in multiple directions to improve the uniformity of culture medium distribution and improve cell culture effect is the technical problem to be solved by this invention. So we propose a shaking device for cell culture that is easy to adjust. Summary of the Invention

[0004] To solve the above-mentioned technical problems, the present invention provides a cell culture shaking device that is easy to adjust, comprising:

[0005] The outer casing has a bracket fixedly connected to its outer side and an end cap snapped onto its top.

[0006] A shaking mechanism is disposed inside the outer casing and is fixedly connected to the bottom of the inner side of the outer casing.

[0007] The shaking mechanism includes:

[0008] A shaking plate is inclinedly disposed inside the outer casing, and a plurality of holes are formed on the surface of the shaking plate;

[0009] A limiting component is fixedly connected to the inner side of the shaking plate;

[0010] A drive assembly is fixedly connected to the bottom of the inner side of the housing, and the side of the drive assembly near the end cover is engaged with the surface spline of the limiting assembly.

[0011] A clamping assembly, which is fixedly connected to the inner wall of the hole in the shaking plate;

[0012] Open the end cap and place the culture flask into the hole of the shaking plate. Then, activate the clamping assembly to fix the culture flask in place. Next, activate the drive assembly, which sequentially drives the limiting assembly, the shaking plate, and the clamping assembly to rotate, ultimately causing the culture flask to rotate. Due to the tilted setting of the shaking plate, the culture flask not only generates horizontal circular motion during rotation but also moves up and down with the inclined surface of the shaking plate. During one revolution around the drive assembly, the culture flask will experience a complete rising and falling process, forming a three-dimensional composite oscillation effect. This causes complex relative movement between the culture medium and the culture flask, which can more efficiently promote cell-nutrient contact and enhance gas exchange efficiency compared to traditional planar oscillation.

[0013] Furthermore, four protrusions are fixedly connected to the outer side of the shaking plate, and a top block is fixedly connected to the inner side of the outer shell. When the shaking plate rotates, it drives the protrusions to rotate, and the protrusions contact the top block, creating pressure. Subsequently, the protrusions and the shaking plate move, and then the limiting component moves, causing the center of the shaking plate to move relative to the rotation center of the driving component. This causes the driving component to drive the shaking plate to rotate eccentrically. When the shaking plate rotates eccentrically, the cell suspension in the culture flask will be subjected to periodically changing centrifugal force and inertial force, forming a more complex fluid motion trajectory, thereby obtaining a better shaking effect.

[0014] Furthermore, the limiting component includes an eccentric ring, which is inclinedly arranged inside the housing. The inner side of the eccentric ring is slidably connected to the output end of the drive component. A dovetail plate is fixedly connected to the inner side of the eccentric ring. The surface of the dovetail plate is splinedly engaged with the output end of the drive component. When the output end of the drive component rotates, it drives the dovetail plate to rotate, which in turn drives the eccentric ring to rotate, ultimately causing the shaking plate to rotate. The eccentric ring is engaged with the drive component through the dovetail plate, allowing the shaking plate to be removed for easier installation of culture flasks.

[0015] Furthermore, a limiting rod is fixedly connected to the outer side of the eccentric ring. Four limiting rods are arranged circumferentially along the eccentric ring, and a limiting block is provided on the side of each of the four limiting rods away from the eccentric ring. The inner side of the limiting block is slidably connected to the surface of the limiting rod, and a limiting groove plate is slidably connected to the outer side of the limiting block. The side of the limiting groove plate away from the limiting block is fixedly connected to the inner side of the shaking plate. The four limiting blocks and the limiting groove plate are interlocked with each other, which can prevent unnecessary shaking during normal rotation. When the protrusion and the top block are squeezed, the shaking plate... The two parallel limiting groove plates move relative to the eccentric ring, and the limiting groove plates slide outside the limiting block, thereby causing the shaking plate to rotate eccentrically. The other two limiting groove plates drive the limiting block to slide outside the limiting rod, thus avoiding affecting the eccentric rotation of the shaking plate. As the shaking plate rotates, the two sets of parallel limiting groove plates and the eccentric ring continuously move relative to each other, causing the centrifugal force and inertial force on the liquid in the culture bottle to continuously change direction and magnitude, forming a turbulent mixing effect, which ensures that the solution in the culture bottle is fully mixed and significantly improves the uniformity of contact between the culture medium and cells.

[0016] Furthermore, a spring is sleeved on the outside of the limiting rod. The end of the spring away from the eccentric ring is fixedly connected to the surface of the end of the limiting rod away from the eccentric ring. The end of the spring away from the limiting rod is fixedly connected to the inner side of the limiting block. The limiting rod slides inside the limiting block, causing the spring to deform, thereby achieving a buffering effect. At the same time, in the normal rotation state, the spring maintains a certain preload, so that the limiting block and the limiting groove plate fit tightly together, avoiding shaking or noise caused by gaps.

[0017] Furthermore, the drive assembly includes a motor, which is fixedly connected to the bottom of the inner side of the housing. A rotating shaft is fixedly connected to the side of the motor near the end cover, and the output end of the motor is fixedly connected to the rotating shaft. The surface of the rotating shaft is splinedly engaged with the surface of the dovetail plate, and the inner side of the eccentric ring is slidably connected to the surface of the rotating shaft. A bolt is provided at the end of the rotating shaft away from the motor, and the bolt is threadedly connected to the end of the rotating shaft. When the motor is started, the output end of the motor drives the rotating shaft to rotate, the rotating shaft drives the dovetail plate to rotate, and finally drives the shaking plate to rotate. After the bolt is threadedly connected to the rotating shaft, the dovetail plate is pressed tightly, thereby preventing the dovetail plate from moving axially outside the rotating shaft and preventing the shaking plate from loosening when rotating.

[0018] Furthermore, the clamping assembly includes clamping plates, which are annular in shape, and two clamping plates are symmetrically arranged in the holes of the shaking plate. Adhesive strips are fixedly connected to the sides of the two clamping plates that are close to each other, and the adhesive strips are evenly distributed on the surface of the clamping plates. The adhesive strips are wavy in shape. When a culture flask is placed between the two clamping plates, the two clamping plates are driven to move closer together to clamp the culture flask. The adhesive strips increase the friction between the clamping plates and the culture flask, resulting in better fixation. The wavy material of the adhesive strips also increases the vertical resistance of the culture flask, thus preventing it from falling.

[0019] Furthermore, each of the two clamping plates is fixedly connected to a telescopic rod on the side closest to each other. There are two sets of telescopic rods, and the two sets of telescopic rods are symmetrically arranged with the clamping plate as the center. Each set of telescopic rods has two rods. The sides of the two telescopic rods that are close to each other are fixed together. When the telescopic rods are activated, they move the two clamping plates closer to each other or further apart, thereby making it easier to clamp or release culture bottles of different sizes.

[0020] Furthermore, a connecting shell is fitted around the joint where the two telescopic rods in each group are fixed to each other, and the inner side of the connecting shell is fixedly connected to the outer side of the two telescopic rods in the same group. A screw is fixedly connected to the side of the two connecting shells that are far apart from each other, and the screw is made of elastic material. The inner wall of the shaking plate has symmetrically opened circular holes, and the end of the screw that is far away from the connecting shell extends into the circular hole and is fixedly connected to the bottom of the inner wall of the circular hole. When the shaking plate rotates irregularly, the clamping plate shakes, which in turn causes the screw to deform, thereby causing the culture flask to shake and achieve a better shaking effect.

[0021] Furthermore, protective rings are provided at both ends of the inner wall of the shaking plate hole, and the outer side of the protective rings is fixedly connected to the inner wall of the shaking plate hole. The protective rings are made of rubber, and there is a gap between the protective rings and the inner wall of the shaking plate hole. When the culture flask is shaken, the rubber protective rings protect the inner wall of the shaking plate hole. Compared with the impact that occurs when shaking, the gap between the protective rings and the inner wall of the shaking plate hole allows the protective rings to expand towards the inner wall of the hole when under pressure, forming a cushioning effect similar to an air cushion. This double-layer cushioning structure effectively reduces contact stress and further prevents the culture flask from being damaged.

[0022] The beneficial effects of this invention are as follows:

[0023] 1. This invention, by setting up a shaking mechanism, causes the culture flask to not only generate horizontal circular motion during rotation due to the inclined setting of the shaking plate, but also to generate vertical displacement along the inclined surface of the shaking plate. During one revolution around the driving component, the culture flask will experience a complete rising and falling process, forming a three-dimensional composite oscillation effect, which promotes complex relative movement between the culture medium and the culture flask. Compared with traditional planar oscillation, it can more efficiently promote the contact between cells and nutrients and enhance gas exchange efficiency.

[0024] 2. This invention, by setting a limiting component, has four limiting blocks and limiting groove plates interlocking with each other, which can avoid unnecessary shaking during normal rotation. When the protrusion and the top block are squeezed, the two parallel limiting groove plates and the eccentric ring of the shaking plate move relative to each other, and the limiting groove plates slide outside the limiting blocks, thereby causing the shaking plate to rotate eccentrically. The other two limiting groove plates drive the limiting blocks to slide outside the limiting rod, thereby avoiding affecting the eccentric rotation of the shaking plate. As the shaking plate rotates, the two sets of parallel limiting groove plates and the eccentric ring continuously move relative to each other, causing the centrifugal force and inertial force on the liquid in the culture bottle to continuously change direction and magnitude, forming a turbulent mixing effect and a more complex fluid motion trajectory, so that the solution in the culture bottle is fully mixed, significantly improving the contact uniformity between the culture medium and cells. In the normal rotation state, the spring maintains a certain preload, so that the limiting blocks and limiting groove plates fit tightly, avoiding shaking or noise caused by gaps.

[0025] 3. By setting up clamping plates, the adhesive strips can increase the friction between the clamping plates and the culture flasks, resulting in a better fixing effect. The corrugated material of the adhesive strips can increase the vertical resistance of the culture flasks, thereby preventing them from falling. At the same time, the two annular clamping plates can move closer or further apart, making it easier to clamp or release culture flasks of different sizes, and facilitating adjustment when fixing culture flasks of different sizes.

[0026] 4. By setting a protective ring, the rubber protective ring protects the inner wall of the hole of the shaking plate when the culture flask is shaken. Compared with the impact that occurs when shaking, there is a gap between the protective ring and the inner wall of the hole of the shaking plate, which allows the protective ring to expand towards the inner wall of the hole when under pressure, forming a cushioning effect similar to an air cushion. This double-layer cushioning structure effectively reduces contact stress and further prevents the culture flask from being damaged. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the easily adjustable shaking device for cell culture according to the present invention;

[0028] Figure 2 This is a schematic diagram of the cross-sectional structure of the outer shell of the present invention;

[0029] Figure 3This is a schematic diagram of the internal structure of the cell culture shaking device of the present invention, which is easy to adjust.

[0030] Figure 4 This is a schematic diagram of the shaking plate structure of the present invention;

[0031] Figure 5 This is a schematic diagram of the cross-sectional structure of the limiting groove plate of the present invention;

[0032] Figure 6 This is a schematic diagram of the cross-sectional structure of the limiting block of the present invention;

[0033] Figure 7 This is a schematic diagram of the drive component structure of the present invention;

[0034] Figure 8 This is a schematic diagram of the cross-sectional structure of the shaking plate of the present invention;

[0035] Figure 9 This is a schematic diagram of the clamping component structure of the present invention;

[0036] Figure 10 This is a schematic diagram of the cross-sectional structure of the protective ring of the present invention.

[0037] In the diagram: 1. Outer shell; 2. Bracket; 3. Shaking mechanism; 31. Shaking plate; 32. Limiting assembly; 321. Eccentric ring; 322. Dovetail plate; 323. Limiting groove plate; 324. Limiting block; 325. Limiting rod; 326. Spring; 33. Drive assembly; 331. Motor; 332. Shaft; 333. Bolt; 34. Clamping assembly; 341. Clamping plate; 342. Telescopic rod; 343. Connecting shell; 344. Round hole; 345. Screw; 346. Rubber strip; 347. Protective ring; 35. Protrusion; 36. Top block; 4. End cap. Detailed Implementation

[0038] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments. The embodiments of the present invention are given for illustrative and descriptive purposes only, and are not intended to be exhaustive or to limit the invention to the forms disclosed. Many modifications and variations will be apparent to those skilled in the art. The embodiments were chosen and described to better illustrate the principles and practical application of the invention, and to enable those skilled in the art to understand the invention and design various embodiments with various modifications suitable for a particular purpose.

[0039] Example 1, please refer to Figures 1-7 The present invention is a cell culture shaking device that is easy to adjust, comprising:

[0040] The outer casing 1 has a bracket 2 fixedly connected to its outer side and an end cap 4 snapped to its top.

[0041] A shaking mechanism 3 is disposed inside the outer casing 1 and is fixedly connected to the bottom of the inner side of the outer casing 1.

[0042] The shaking mechanism 3 includes:

[0043] A shaking plate 31 is inclinedly disposed inside the outer casing 1, and a number of holes are formed on the surface of the shaking plate 31.

[0044] Limiting component 32 is fixedly connected to the inner side of the shaking plate 31;

[0045] The drive assembly 33 is fixedly connected to the bottom of the inner side of the housing 1, and the side of the drive assembly 33 near the end cover 4 is engaged with the surface spline of the limiting assembly 32.

[0046] Clamping assembly 34 is fixedly connected to the inner wall of the hole of the shaking plate 31;

[0047] Open the end cap 4 and place the culture flask into the hole of the shaking plate 31. Then, activate the clamping assembly 34 to fix the culture flask. Next, activate the driving assembly 33. The driving assembly 33 sequentially drives the limiting assembly 32, the shaking plate 31, and the clamping assembly 34 to rotate, ultimately causing the culture flask to rotate. Due to the inclined setting of the shaking plate 31, the culture flask not only generates horizontal circular motion during rotation, but also moves up and down with the inclined surface of the shaking plate 31. During one revolution around the driving assembly 33, the culture flask will experience a complete rising and falling process, forming a three-dimensional composite oscillation effect. This causes the culture medium and the culture flask to generate complex relative movement. Compared with traditional planar oscillation, it can more efficiently promote the contact between cells and nutrients and enhance gas exchange efficiency.

[0048] The outer side of the shaking plate 31 is fixedly connected with protrusions 35, and four protrusions 35 are provided. The inner side of the outer shell 1 is fixedly connected with a top block 36. When the shaking plate 31 rotates, it drives the protrusions 35 to rotate. The protrusions 35 contact the top block 36 and squeeze with the top block 36. Then the protrusions 35 and the shaking plate 31 move. Then the limiting component 32 moves, so that the center of the shaking plate 31 and the rotation center of the driving component 33 move relative to each other. This causes the driving component 33 to drive the shaking plate 31 to rotate eccentrically. When the shaking plate 31 rotates eccentrically, the cell suspension in the culture flask will be subjected to periodically changing centrifugal force and inertial force, forming a more complex fluid motion trajectory, thereby obtaining a better shaking effect.

[0049] The limiting component 32 includes an eccentric ring 321, which is inclinedly arranged inside the housing 1. The inner side of the eccentric ring 321 is slidably connected to the output end of the drive component 33. A dovetail plate 322 is fixedly connected to the inner side of the eccentric ring 321. The surface of the dovetail plate 322 is splinedly engaged with the output end of the drive component 33. When the output end of the drive component 33 rotates, it drives the dovetail plate 322 to rotate, which in turn drives the eccentric ring 321 to rotate, ultimately driving the shaking plate 31 to rotate. The eccentric ring 321 is engaged with the drive component 33 through the dovetail plate 322, allowing the shaking plate 31 to be removed for easier installation of culture flasks.

[0050] A limiting rod 325 is fixedly connected to the outer side of the eccentric ring 321. Four limiting rods 325 are arranged circumferentially along the eccentric ring 321, and each of the four limiting rods 325 has a limiting block 324 on the side away from the eccentric ring 321. The inner side of the limiting block 324 is slidably connected to the surface of the limiting rod 325, and the outer side of the limiting block 324 is slidably connected to a limiting groove plate 323. The side of the limiting groove plate 323 away from the limiting block 324 is fixedly connected to the inner side of the shaking plate 31. The four limiting blocks 324 and the limiting groove plate 323 are interlocked to prevent unnecessary shaking during normal rotation. When the protrusion 35 and the top block 36 are pressed together, the shaking plate 31... Two parallel limiting groove plates 323 and eccentric ring 321 move relative to each other. The limiting groove plates 323 slide outside the limiting block 324, causing the shaking plate 31 to rotate eccentrically. The other two limiting groove plates 323 drive the limiting block 324 to slide outside the limiting rod 325, thereby avoiding affecting the eccentric rotation of the shaking plate 31. As the shaking plate 31 rotates, the two sets of parallel limiting groove plates 323 and eccentric ring 321 continuously move relative to each other, causing the centrifugal force and inertial force on the liquid in the culture bottle to continuously change direction and magnitude, forming a turbulent mixing effect, which makes the solution in the culture bottle fully mixed and significantly improves the uniformity of contact between the culture medium and cells.

[0051] A spring 326 is sleeved on the outside of the limiting rod 325. The end of the spring 326 away from the eccentric ring 321 is fixedly connected to the surface of the end of the limiting rod 325 away from the eccentric ring 321. The end of the spring 326 away from the limiting rod 325 is fixedly connected to the inner side of the limiting block 324. The limiting rod 325 slides inside the limiting block 324, causing the spring 326 to deform, thereby achieving a buffering effect. At the same time, in the normal rotation state, the spring 326 maintains a certain preload, so that the limiting block 324 and the limiting groove plate 323 fit tightly together, avoiding shaking or noise caused by gaps.

[0052] The drive assembly 33 includes a motor 331, which is fixedly connected to the bottom of the inner side of the housing 1. A rotating shaft 332 is fixedly connected to the side of the motor 331 near the end cover 4, and the output end of the motor 331 is fixedly connected to the rotating shaft 332. The surface of the rotating shaft 332 is splinedly engaged with the surface of the dovetail plate 322, and the inner side of the eccentric ring 321 is slidably connected to the surface of the rotating shaft 332. A bolt 333 is provided at the end of the rotating shaft 332 away from the motor 331, and the bolt 333 is threadedly connected to the end of the rotating shaft 332. When the motor 331 is started, the output end of the motor 331 drives the rotating shaft 332 to rotate, which in turn drives the dovetail plate 322 to rotate, and finally drives the shaking plate 31 to rotate. After the bolt 333 is threadedly connected to the rotating shaft 332, it presses the dovetail plate 322 tightly, thereby preventing the dovetail plate 322 from moving axially outside the rotating shaft 332 and preventing the shaking plate 31 from loosening when rotating.

[0053] Example 2, please refer to Figures 1-10 The clamping assembly 34 includes a clamping plate 341, which is annular and two clamping plates 341 are symmetrically arranged in the holes of the shaking plate 31. Adhesive strips 346 are fixedly connected to the sides of the two clamping plates 341 that are close to each other, and the adhesive strips 346 are evenly distributed on the surface of the clamping plate 341. The adhesive strips 346 are wavy. When the culture flask is placed at the interval between the two clamping plates 341, the two clamping plates 341 are driven to move closer to each other to clamp the culture flask. The adhesive strips 346 can increase the friction between the clamping plate 341 and the culture flask, resulting in a better fixing effect. The wavy material of the adhesive strips 346 can increase the vertical resistance of the culture flask, thereby preventing the culture flask from falling.

[0054] Two telescopic rods 342 are fixedly connected to the sides of the two clamping plates 341 that are close to each other. There are two sets of telescopic rods 342, which are symmetrically arranged with the clamping plates 341 as the center. There are two telescopic rods 342 in each set. The sides of the two telescopic rods 342 that are close to each other are fixed to each other. When the telescopic rods 342 are activated, they move the two clamping plates 341 closer to each other or further apart, so as to more conveniently clamp or release culture bottles of different sizes.

[0055] Each pair of telescopic rods 342 is fitted with a connecting shell 343 at the point where they are fixed together. The inner side of the connecting shell 343 is fixedly connected to the outer side of the two telescopic rods 342 in the same group. A screw 345 is fixedly connected to the side of the two connecting shells 343 that is far away from each other. The screw 345 is made of elastic material. The inner wall of the shaking plate 31 has symmetrically opened circular holes 344. The end of the screw 345 that is far away from the connecting shell 343 extends into the circular hole 344 and is fixedly connected to the bottom of the inner wall of the circular hole 344. When the shaking plate 31 rotates irregularly, the clamping plate 341 shakes, which in turn causes the screw 345 to deform, thereby causing the culture bottle to shake and achieving a better shaking effect.

[0056] Protective rings 347 are provided at both ends of the inner wall of the shaking plate 31. The outer side of the protective rings 347 is fixedly connected to the inner wall of the shaking plate 31. The protective rings 347 are made of rubber. There is a gap between the protective rings 347 and the inner wall of the shaking plate 31. When the culture flask is shaken, the rubber protective rings 347 protect the inner wall of the shaking plate 31. Compared with the impact that occurs when shaking, the gap between the protective rings 347 and the inner wall of the shaking plate 31 allows the protective rings 347 to expand towards the inner wall of the hole when under pressure, forming a cushioning effect similar to an air cushion. This double-layer cushioning structure effectively reduces contact stress and further prevents the culture flask from being damaged.

[0057] In use, open end cap 4, place the culture flask into the hole of shaking plate 31, activate telescopic rod 342. Telescopic rod 342 drives the two clamping plates 341 to move closer or further apart, thereby achieving clamping. Activate motor 331. The output end of motor 331 drives rotating shaft 332 to rotate. Rotating shaft 332 drives dovetail plate 322 to rotate, drives eccentric ring 321 to rotate, drives limiting rod 325 to rotate, drives limiting block 324 to rotate, drives limiting groove plate 323 to rotate, and finally drives shaking plate 31 to rotate. After bolt 333 is threadedly connected to rotating shaft 332, it presses dovetail plate 322 tightly. Shaking plate 31 rotates, driving protrusion 35 to rotate. Protrusion 35 contacts top block 36, creating pressure with top block 36. Subsequently, protrusion... 35. When the shaking plate 31 moves, and then the protrusion 35 and the top block 36 press against each other, the two parallel limiting groove plates 323 and the eccentric ring 321 of the shaking plate 31 move relative to each other. The limiting groove plates 323 slide outside the limiting block 324, thereby causing the shaking plate 31 to rotate eccentrically. The other two limiting groove plates 323 drive the limiting block 324 to slide outside the limiting rod 325, thereby avoiding affecting the eccentric rotation of the shaking plate 31. As the shaking plate 31 rotates, the two parallel sets of limiting groove plates 323 and the eccentric ring 321 continuously move relative to each other, causing the center of the shaking plate 31 to move relative to the rotation center of the drive assembly 33, so that the drive assembly 33 drives the shaking plate 31 to rotate eccentrically.

[0058] Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. All other embodiments obtained by those skilled in the art and related fields based on the embodiments of the present invention without inventive effort should fall within the scope of protection of the present invention. Structures, devices, and operating methods not specifically described and explained in the present invention, unless otherwise specified or limited, shall be implemented according to conventional means in the art.

Claims

1. A cell culture shaking device that is easy to adjust, characterized in that, include: The outer shell (1) has a bracket (2) fixedly connected to its outer side and an end cap (4) snapped to its top. A shaking mechanism (3) is provided inside the outer shell (1) and is fixedly connected to the bottom of the inner side of the outer shell (1); The shaking mechanism (3) includes: A shaking plate (31) is inclinedly disposed inside the outer shell (1), and a plurality of holes are provided on the surface of the shaking plate (31). A limiting component (32) is fixedly connected to the inner side of the shaking plate (31); The drive assembly (33) is fixedly connected to the bottom of the inner side of the housing (1), and the side of the drive assembly (33) near the end cover (4) is engaged with the surface spline of the limiting assembly (32). A clamping assembly (34) is fixedly connected to the inner wall of the hole of the shaking plate (31); The limiting component (32) includes an eccentric ring (321), and the eccentric ring (321) is inclinedly arranged inside the housing (1). The inner side of the eccentric ring (321) is slidably connected to the output end of the drive component (33). A dovetail plate (322) is fixedly connected to the inner side of the eccentric ring (321), and the surface of the dovetail plate (322) is splinedly engaged with the output end of the drive component (33). The outer side of the eccentric ring (321) is fixedly connected to a limiting rod (325). Four limiting rods (325) are arranged along the circumference of the eccentric ring (321). Each of the four limiting rods (325) is provided with a limiting block (324) on the side away from the eccentric ring (321). The inner side of the limiting block (324) is slidably connected to the surface of the limiting rod (325). The outer side of the limiting block (324) is slidably connected to a limiting groove plate (323). The side of the limiting groove plate (323) away from the limiting block (324) is fixedly connected to the inner side of the shaking plate (31). A spring (326) is sleeved on the outside of the limiting rod (325). The end of the spring (326) away from the eccentric ring (321) is fixedly connected to the surface of the end of the limiting rod (325) away from the eccentric ring (321). The end of the spring (326) away from the limiting rod (325) is fixedly connected to the inner side of the limiting block (324). The outer side of the shaking plate (31) is fixedly connected to a protrusion (35), and four protrusions (35) are provided. The inner side of the outer shell (1) is fixedly connected to a top block (36).

2. The easily adjustable cell culture shaking device according to claim 1, characterized in that: The drive assembly (33) includes a motor (331), which is fixedly connected to the bottom of the inner side of the housing (1). A rotating shaft (332) is fixedly connected to the side of the motor (331) near the end cover (4), and the output end of the motor (331) is fixedly connected to the rotating shaft (332). The surface of the rotating shaft (332) is splined with the surface of the dovetail plate (322), and the inner side of the eccentric ring (321) is slidably connected to the surface of the rotating shaft (332). A bolt (333) is provided at the end of the rotating shaft (332) away from the motor (331), and the bolt (333) is threadedly connected to the end of the rotating shaft (332).

3. The easily adjustable cell culture shaking device according to claim 2, characterized in that: The clamping assembly (34) includes a clamping plate (341), which is annular and two clamping plates (341) are symmetrically arranged in the holes of the shaking plate (31). Each of the two clamping plates (341) is fixedly connected with an adhesive strip (346) on the side that is close to each other, and the adhesive strip (346) is evenly distributed on the surface of the clamping plate (341). The adhesive strip (346) is wavy.

4. The easily adjustable cell culture shaking device according to claim 3, characterized in that: Each of the two clamping plates (341) is fixedly connected to a telescopic rod (342) on the side that is close to each other. There are two sets of telescopic rods (342), and the two sets of telescopic rods (342) are symmetrically arranged with the clamping plate (341) as the center. Each set of telescopic rods (342) has two, and the two telescopic rods (342) are fixed to each other on the side that is close to each other.

5. The easily adjustable cell culture shaking device according to claim 4, characterized in that: Each pair of telescopic rods (342) is fitted with a connecting shell (343) at the point where they are fixed together. The inner side of the connecting shell (343) is fixedly connected to the outer side of the two telescopic rods (342) in the same group. A screw (345) is fixedly connected to the side of the two connecting shells (343) that is far away from each other. The screw (345) is made of elastic material. The inner wall of the shaking plate (31) is symmetrically provided with round holes (344). The end of the screw (345) that is far away from the connecting shell (343) extends into the round hole (344) and is fixedly connected to the bottom of the inner wall of the round hole (344).

6. The easily adjustable cell culture shaking device according to claim 5, characterized in that: Protective rings (347) are provided at both ends of the inner wall of the hole of the shaking plate (31), and the outer side of the protective ring (347) is fixedly connected to the inner wall of the hole of the shaking plate (31). The protective ring (347) is made of rubber material, and there is a gap between the protective ring (347) and the inner wall of the hole of the shaking plate (31).

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