Pollen-based compositions and extracts for stimulating hyaluronic acid production

By using pollen compositions or extracts containing glucose-6-phosphate and other bioactive molecules, concentrated extracts are prepared using a mild fermentation process, which solves the problem that topical hyaluronic acid preparations are difficult to pass through the skin barrier, thereby achieving effective hyaluronic acid stimulation of skin cells and treatment of GSM symptoms.

CN120641076APending Publication Date: 2025-09-12WILL SCIENCE CO LTD
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Patent Information

Application Number
CN202380093123.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2022-12-02
Filing Date
2023-12-01
Publication Date
2025-09-12

AI Technical Summary

Technical Problem

Existing topical hyaluronic acid preparations have difficulty effectively penetrating the skin barrier, and active ingredients such as retinol and bakuchiol may cause cell damage. The market demands more effective, non-invasive and gentle anti-aging and GSM symptom treatment products.

Method used

Pollen compositions or extracts containing glucose-6-phosphate as a substrate for hyaluronic acid production are prepared by combining other bioactive molecules through a mild fermentation and germination process to stimulate the production of hyaluronic acid.

Benefits of technology

It effectively stimulates skin cells to produce hyaluronic acid, improves skin conditions, treats and prevents GSM symptoms, has antibacterial effects, and is more gentle and non-invasive.

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Abstract

The present invention relates to a pollen-based composition or an extract from a pollen-based composition, wherein the composition or extract stimulates the production of hyaluronic acid (HA). The composition or extract comprises at least glucose-6-phosphate as a substrate or precursor for hyaluronic acid (HA) production. The compositions or extracts of the present invention further comprise other small molecular weight bioactive molecules and / or compounds selected from the group comprising flavonoids, flavonols, flavones, alkaloids, aglycones, glycosides, lipids, fatty acids, amino acids, anthranilic acids and isomers thereof, spermidine and isomers thereof, a caffeoyl spermidine compound; and hydroxycinnamic acid. The invention also relates to formulations comprising a pollen-based composition or extract useful for the treatment of a variety of conditions, including skin problems and skin aging as well as symptoms of climacteric genitourinary syndrome (GSM), the symptoms of the climacteric genitourinary syndrome (GSM) include urinary incontinence, vaginal dryness, vaginal atrophy, irritation, pruritus, rhagadia, thinning, redness, inflammation and a decline in sexual desire, sexual function, sexual response and / or sexual pleasure.
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