Recombinant collagen dressing patch for treating haemorrhoids and preparation method of recombinant collagen dressing patch

Abstract

The invention relates to a recombinant collagen dressing patch for treating haemorrhoids and a preparation method of the recombinant collagen dressing patch, and belongs to the technical field of production of medical apparatuses and instruments. Comprising a first patch used for being pasted on the hip skin on one side and a second patch used for being pasted on the hip skin on the other side, the first patch and the second patch are located on the two sides of an elastic protruding structure respectively, the shape of the elastic protruding structure is matched with the curve of the butt cleavage of the human body, and a hydrogel dressing layer is arranged on the protruding face of the elastic protruding structure. The two sides of the base are provided with a plurality of left side binding strips and a plurality of right side binding strips respectively. The novel hemorrhoid dressing has the advantages that the shape of the elastic protruding structure is matched with the curve of the cleavage of the human body, the novel hemorrhoid dressing can be easily inserted into the cleavage of the human body, it is ensured that the dressing can completely cover the external hemorrhoid nucleus and the surrounding mucous membrane, and the hip skin on the two sides of the anus can be pulled through the arrangement of the left tying belt strip and the right tying belt strip; it is guaranteed that the elastic protruding structures are accurately embedded into the gluteal cleavage, displacement is avoided, and it is guaranteed that the hydrogel dressing layer continuously covers the wound surface.

Description

Technical Field

[0001] The invention relates to a recombinant collagen dressing for treating hemorrhoids and a preparation method thereof, and belongs to the technical field of medical device production. Background Art

[0002] Hemorrhoids are mainly divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids, and their clinical manifestations are different. Internal hemorrhoids mainly present as blood in the stool and prolapse, while external hemorrhoids mainly present as swelling, pain, itching, foreign body sensation, etc. Mixed hemorrhoids have the clinical manifestations of both internal and external hemorrhoids. During the nursing process, patients should keep the local hygiene of the anus clean, develop the good habit of warm water anal sitz bath after defecation or before going to bed, and exercise moderately every day.

[0003] A search revealed patent number 202311134774.9, which discloses a gel dressing composed of the following ingredients by weight: EDTA, glycerin, propylene glycol + parahydroxyacetophenone, carbomer 980, triethanolamine, purified water, borneol, dandelion, phellodendron, wild chrysanthemum, ginseng, donkey-hide gelatin, poria, and menthol. The anti-inflammatory and detumescent essences of traditional Chinese medicines such as phellodendron, dandelion, and wild chrysanthemum are extracted through boiling and filtering. These essences are then coated with excipients such as EDTA, carbomer 980, and triethanolamine. This gel dressing for hemorrhoid treatment allows for faster and more effective application to the affected area. It not only offers stable efficacy without any toxic side effects, but also improves the patient's physical function and reduces the risk of hemorrhoid recurrence.

[0004] Although the above patent has the advantage of stable efficacy, it has the following disadvantages: traditional external hemorrhoid dressings mostly adopt a flat patch design, which cannot fit the curve of the gluteal groove and is easily displaced due to the squeezing of the buttocks muscles when lying on the side.

[0005] In order to solve one of the above problems, a recombinant collagen dressing for treating hemorrhoids and a preparation method thereof are urgently needed. Summary of the Invention

[0006] In view of the above deficiencies in the existing technology, the technical problem to be solved by the present invention is: how to ensure that the dressing can completely cover the external hemorrhoids and the surrounding mucosa, including the lesion area of ​​the external hemorrhoids, and the hydrogel dressing layer continuously covers the wound surface. To this end, a recombinant collagen dressing patch for the treatment of hemorrhoids and a preparation method thereof are provided, which need to be solved through the coordinated solution of bionic surface design and a bidirectional mechanical traction system.

[0007] The recombinant collagen dressing patch for treating hemorrhoids described in the present invention is characterized in that it includes a first patch for being adhered to the skin of one buttock and a second patch for being adhered to the skin of the other buttock, the first patch and the second patch are respectively located on both sides of an elastic raised structure, the shape of the elastic raised structure coincides with the curve of the buttock groove of the human body, the protruding surface of the elastic raised structure has a hydrogel dressing layer, the mounting plane of the elastic raised structure has a base, and multiple left-side tie strips and right-side tie strips are respectively provided on both sides of the base, the second patch is provided with a buckle A that cooperates with the left-side tie strip, and the first patch is provided with a buckle B that cooperates with the right-side tie strip, and the upper surface of the hydrogel dressing layer is covered with a layer of PU film.

[0008] Designed for the side-lying position, the shape of the elastic raised structure matches the curve of the human buttock groove, which is convenient for insertion into the buttock groove, ensuring that the dressing can completely cover the external hemorrhoids and surrounding mucosa, including the lesion area of ​​the external hemorrhoids. The second patch is provided with a buckle A that cooperates with the left tie strip, and the first patch is provided with a buckle B that cooperates with the right tie strip. By pulling the left tie strip and the right tie strip respectively, the buttocks skin on both sides of the anus can be pulled to ensure that the elastic raised structure is accurately embedded in the buttock groove to avoid displacement and ensure that the hydrogel dressing layer continuously covers the wound surface.

[0009] In any of the above solutions, preferably, the elastic protrusion structure is roughly in the shape of a triangular pyramid, with two smooth and concave side surfaces and a cross-sectional height of 2-3 cm.

[0010] In any of the above solutions, preferably, the elastic protrusion structure is made of silicone.

[0011] In any of the above solutions, preferably, the hydrogel dressing layer has raised patterns.

[0012] In any of the above schemes, preferably, the hydrogel dressing layer comprises the following components in parts by mass: 280-320 parts of hydroxypropyl chitosan, 230-270 parts of hydroxybutyl chitosan, 330-370 parts of sodium alginate, 35-45 parts of low-fat pectin, 50-70 parts of antibacterial nano-silver powder, 140-160 parts of traditional Chinese medicine extract, 8-12 parts of epidermal growth factor, 60-80 parts of sodium hyaluronate, and 180-220 parts of recombinant human collagen.

[0013] In any of the above schemes, preferably, the hydrogel dressing layer comprises the following components in parts by mass: 300 parts of hydroxypropyl chitosan, 250 parts of hydroxybutyl chitosan, 350 parts of sodium alginate, 40 parts of low-fat pectin, 60 parts of antibacterial nano-silver powder, 150 parts of traditional Chinese medicine extract, 10 parts of epidermal growth factor, 70 parts of sodium hyaluronate, and 200 parts of recombinant human collagen.

[0014] In any of the above schemes, preferably, the Chinese medicine extract is gallnut, phellodendron, dandelion, poria, wild chrysanthemum, ginseng, donkey-hide gelatin, sophora flavescens, Panax notoginseng, sanguisorba officinalis charcoal, lithospermum officinale, angelica sinensis, gardenia, calcined oyster shell and borneol.

[0015] In any of the above schemes, it is preferred that the raw materials of the traditional Chinese medicine extract include the following components in parts by weight: 8 parts of gallnut, 12 parts of phellodendron, 15 parts of dandelion, 8 parts of poria, 10 parts of wild chrysanthemum, 5 parts of ginseng, 4 parts of donkey-hide gelatin, 7 parts of sophora flavescens, 5 parts of Panax notoginseng, 10 parts of sanguisorba officinalis charcoal, 8 parts of lithospermum erythrorhizon, 10 parts of angelica, 7 parts of gardenia, 6 parts of calcined oyster shell and 3 parts of borneol.

[0016] Among any of the above schemes, the preferred method for preparing the recombinant collagen dressing for the treatment of hemorrhoids is characterized in that the processing step of the traditional Chinese medicine extract comprises weighing gallnut, phellodendron, dandelion, poria, wild chrysanthemum, ginseng, donkey-hide gelatin, sophora flavescens, Panax notoginseng, sanguisorba officinalis charcoal, lithospermum officinale, angelica sinensis, gardenia, calcined oyster shell and borneol as needed; mixing the above raw material components and decocting them with water for 1 hour, with the amount of water added being 15 to 20 times the total weight of the raw materials; filtering the above traditional Chinese medicine liquid and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 0.9 to 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract.

[0017] In any of the above schemes, it is preferred that collagen is added to the traditional Chinese medicine extract and swelled completely to obtain a collagen mixture, which is then mixed with hydroxypropyl chitosan, hydroxybutyl chitosan, sodium alginate, low-fat pectin, antibacterial nano-silver powder, epidermal growth factor, and sodium hyaluronate to prepare a recombinant collagen dressing.

[0018] Compared with the prior art, the present invention has the following beneficial effects: The recombinant collagen dressing for the treatment of hemorrhoids described in the present invention is designed for the side-lying position. The shape of the elastic protrusion structure matches the curve of the human buttock groove, which is convenient for insertion into the buttock groove, ensuring that the dressing can completely cover the external hemorrhoids and surrounding mucosa, including the lesion area of ​​the external hemorrhoids. The second patch is provided with a buckle A that cooperates with the left tie strip, and the first patch is provided with a buckle B that cooperates with the right tie strip. By pulling the left tie strip and the right tie strip respectively, the buttocks skin on both sides of the anus can be pulled, ensuring that the elastic protrusion structure is accurately embedded in the buttock groove to avoid displacement, and ensuring that the hydrogel dressing layer continuously covers the wound surface.

[0019] The recombinant collagen dressing for treating hemorrhoids and the preparation method thereof described in the present invention can eliminate external hemorrhoids to a certain extent, for example, can reduce the volume of external hemorrhoids and reduce clinical symptoms such as pain, distension, and bleeding caused by external hemorrhoids.

[0020] The recombinant collagen dressing for treating hemorrhoids and the preparation method thereof of the present invention contain epidermal growth factor, sodium hyaluronate and recombinant human collagen components in the cold compress gel, which help accelerate the wound healing process. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the following briefly describes the drawings required for the specific embodiments or the description of the prior art. Similar elements or parts are generally identified by similar reference numerals throughout the drawings. Elements or parts in the drawings are not necessarily drawn to scale.

[0022] Figure 1 It is a structural schematic diagram of the present invention; Figure 2 This is a schematic diagram of the external structure of the elastic protrusion structure of the present invention; In the figure: 1, first patch 2, second patch 3, elastic protrusion structure 4, base 5, hydrogel dressing layer 6, left tie strip 7, right tie strip 8, buckle A 9, buckle B. DETAILED DESCRIPTION

[0023] The present invention will be further described below with reference to the accompanying drawings: The present invention will be further illustrated below through specific embodiments, but the present invention is not limited thereto. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

[0024] Example 1, as Figure 1-2 As shown, the recombinant collagen dressing patch for treating hemorrhoids includes a first patch 1 for sticking on the skin of one buttock, and a second patch 2 for sticking on the skin of the other buttock, the first patch 1 and the second patch 2 are respectively located on both sides of an elastic raised structure 3, the shape of the elastic raised structure 3 is consistent with the curve of the buttock groove of the human body, the protruding surface of the elastic raised structure 3 has a hydrogel dressing layer 5, the mounting plane of the elastic raised structure 3 has a base 4, and the two sides of the base 4 are respectively provided with a plurality of left-side tie strips 6 and right-side tie strips 7, the second patch 2 is provided with a buckle A8 that cooperates with the left-side tie strip 6, the first patch 1 is provided with a buckle B9 that cooperates with the right-side tie strip 7, and the upper surface of the hydrogel dressing layer 5 is covered with a layer of PU film.

[0025] The present application is designed for a side-lying position. The shape of the elastic raised structure 3 matches the curve of the buttock groove of the human body, making it easy to insert into the buttock groove, ensuring that the dressing can completely cover the external hemorrhoids and surrounding mucosa, including the lesion area of ​​the external hemorrhoids. The second patch 2 is provided with a buckle A8 that cooperates with the left tie strip 6, and the first patch 1 is provided with a buckle B9 that cooperates with the right tie strip 7. By pulling the left tie strip 6 and the right tie strip 7 respectively, the buttocks skin on both sides of the anus is pulled to ensure that the elastic raised structure 3 is accurately embedded in the buttock groove to avoid displacement, and to ensure that the hydrogel dressing layer 5 continues to cover the wound surface. 2. The recombinant collagen dressing for the treatment of hemorrhoids according to claim 1 is characterized in that the elastic raised structure 3 is roughly in the shape of a triangular pyramid, with two smooth and concave side surfaces, and the height of its cross section is 2-3 cm.

[0026] Furthermore, the elastic raised structure 3 is made of silicone. Furthermore, the elastic raised structure 3 has raised lines. Furthermore, the hydrogel dressing layer comprises the following components by weight: 300 parts hydroxypropyl chitosan, 250 parts hydroxybutyl chitosan, 350 parts sodium alginate, 40 parts low-fat pectin, 60 parts antibacterial nanosilver powder, 150 parts traditional Chinese medicine extract, 10 parts epidermal growth factor, 70 parts sodium hyaluronate, and 200 parts recombinant human collagen.

[0027] Furthermore, the raw materials of the traditional Chinese medicine extract include the following components in parts by weight: 8 parts of gallnut, 12 parts of phellodendron, 15 parts of dandelion, 8 parts of poria, 10 parts of wild chrysanthemum, 5 parts of ginseng, 4 parts of donkey-hide gelatin, 7 parts of sophora flavescens, 5 parts of Panax notoginseng, 10 parts of sanguisorba officinalis charcoal, 8 parts of lithospermum erythrorhizon, 10 parts of angelica sinensis, 7 parts of gardenia, 6 parts of calcined oyster shell and 3 parts of borneol.

[0028] Example 2, the preparation method of the recombinant collagen dressing for the treatment of hemorrhoids, the processing steps of the traditional Chinese medicine extract, weighing gallnut, phellodendron, dandelion, poria, wild chrysanthemum, ginseng, donkey-hide gelatin, sophora flavescens, Panax notoginseng, sanguisorba officinalis charcoal, lithospermum officinale, angelica sinensis, gardenia, calcined oyster shell and borneol as needed; mixing the above raw material components and decocting them with water for 1 hour, with the amount of water added being 15 to 20 times the total weight of the raw materials; filtering the above traditional Chinese medicine liquid and concentrating the filtrate under reduced pressure, the relative density of the filtrate after reduced pressure concentration being 0.9 to 1.0, and the pressure of reduced pressure concentration being 15 MPa, to obtain the traditional Chinese medicine extract.

[0029] Furthermore, collagen was added to the Chinese medicine extract and swelled completely to prepare a collagen mixture, which was then mixed with hydroxypropyl chitosan, hydroxybutyl chitosan, sodium alginate, low-fat pectin, antibacterial nano-silver powder, 10 parts of epidermal growth factor, and 70 parts of sodium hyaluronate to prepare a recombinant collagen dressing.

[0030] The hydrogel dressing layer includes the following components in parts by mass: 300 parts of hydroxypropyl chitosan, 250 parts of hydroxybutyl chitosan, 350 parts of sodium alginate, 40 parts of low-fat pectin, 60 parts of antibacterial nano-silver powder, 150 parts of traditional Chinese medicine extract, 10 parts of epidermal growth factor, 70 parts of sodium hyaluronate, and 200 parts of recombinant human collagen.

[0031] Furthermore, the raw materials of the traditional Chinese medicine extract include the following components in parts by weight: 8 parts of gallnut, 12 parts of phellodendron, 15 parts of dandelion, 8 parts of poria, 10 parts of wild chrysanthemum, 5 parts of ginseng, 4 parts of donkey-hide gelatin, 7 parts of sophora flavescens, 5 parts of Panax notoginseng, 10 parts of sanguisorba officinalis charcoal, 8 parts of lithospermum erythrorhizon, 10 parts of angelica sinensis, 7 parts of gardenia, 6 parts of calcined oyster shell and 3 parts of borneol.

[0032] Example 3 is different from Example 2 in that the hydrogel dressing layer 5 includes the following components in parts by mass: 280 parts of hydroxypropyl chitosan, 260 parts of hydroxybutyl chitosan, 350 parts of sodium alginate, 40 parts of low-fat pectin, 69 parts of antibacterial nano-silver powder, 158 parts of traditional Chinese medicine extract, 10 parts of epidermal growth factor, 77 parts of sodium hyaluronate, and 210 parts of recombinant human collagen.

[0033] The recombinant collagen dressing for the treatment of hemorrhoids described in the present invention is designed for the side-lying position. The shape of the elastic protrusion structure matches the curve of the human buttock groove, which is convenient for insertion into the buttock groove, ensuring that the dressing can completely cover the external hemorrhoids and surrounding mucosa, including the lesion area of ​​the external hemorrhoids. The second patch is provided with a buckle A that cooperates with the left tie strip, and the first patch is provided with a buckle B that cooperates with the right tie strip. By pulling the left tie strip and the right tie strip respectively, the buttocks skin on both sides of the anus can be pulled, ensuring that the elastic protrusion structure is accurately embedded in the buttock groove to avoid displacement, and ensuring that the hydrogel dressing layer continuously covers the wound surface.

[0034] The recombinant collagen dressing for treating hemorrhoids and the preparation method thereof described in the present invention can eliminate external hemorrhoids to a certain extent, for example, can reduce the volume of external hemorrhoids and reduce clinical symptoms such as pain, distension, and bleeding caused by external hemorrhoids.

[0035] The recombinant collagen dressing for treating hemorrhoids and the preparation method thereof of the present invention contain epidermal growth factor, sodium hyaluronate and recombinant human collagen components in the cold compress gel, which help accelerate the wound healing process.

[0036] The basic principles, main features, and advantages of the present invention are shown and described above. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed in the present invention is defined by the appended claims and their equivalents.

[0037] Any matters not described in detail in the present invention are well-known technologies to those skilled in the art.

Claims

1. A recombinant collagen dressing for the treatment of hemorrhoids, characterized by: It includes a first patch for sticking on the skin of one buttock and a second patch for sticking on the skin of the other buttock, the first patch and the second patch are respectively located on both sides of the elastic raised structure, the shape of the elastic raised structure is consistent with the curve of the buttock groove of the human body, the protruding surface of the elastic raised structure has a hydrogel dressing layer, the mounting plane of the elastic raised structure has a base, and multiple left-side tie strips and right-side tie strips are respectively arranged on both sides of the base, the second patch is provided with a buckle A that cooperates with the left-side tie strip, and the first patch is provided with a buckle B that cooperates with the right-side tie strip, and the upper surface of the hydrogel dressing layer is covered with a layer of PU film.

2. The recombinant collagen dressing for treating hemorrhoids according to claim 1, characterized in that: The elastic protrusion structure is roughly in the shape of a triangular pyramid, with two smooth and concave side surfaces and a cross-sectional height of 2-3 cm.

3. The recombinant collagen dressing for treating hemorrhoids according to claim 2, characterized in that: The elastic protrusion structure is made of silicone.

4. The recombinant collagen dressing for treating hemorrhoids according to claim 2, characterized in that: The hydrogel dressing layer is provided with raised lines.

5. The recombinant collagen dressing for treating hemorrhoids according to claim 4, characterized in that: The hydrogel dressing layer comprises the following components in parts by mass: 280-320 parts of hydroxypropyl chitosan, 230-270 parts of hydroxybutyl chitosan, 330-370 parts of sodium alginate, 35-45 parts of low-fat pectin, 50-70 parts of antibacterial nano-silver powder, 140-160 parts of traditional Chinese medicine extract, 8-12 parts of epidermal growth factor, 60-80 parts of sodium hyaluronate, and 180-220 parts of recombinant human collagen.

6. The recombinant collagen dressing for treating hemorrhoids according to claim 5, characterized in that: The hydrogel dressing layer includes the following components in parts by mass: 300 parts of hydroxypropyl chitosan, 250 parts of hydroxybutyl chitosan, 350 parts of sodium alginate, 40 parts of low-fat pectin, 60 parts of antibacterial nano-silver powder, 150 parts of traditional Chinese medicine extract, 10 parts of epidermal growth factor, 70 parts of sodium hyaluronate, and 200 parts of recombinant human collagen.

7. The recombinant collagen dressing for treating hemorrhoids according to claim 6, characterized in that: The Chinese medicine extract is composed of gallnut, phellodendron, dandelion, tuckahoe, wild chrysanthemum, ginseng, donkey-hide gelatin, sophora flavescens, notoginseng, sanguisorba officinalis charcoal, lithospermum officinale, angelica sinensis, gardenia, calcined oyster shell and borneol.

8. The recombinant collagen dressing for treating hemorrhoids according to claim 7, characterized in that: The raw materials of the traditional Chinese medicine extract include the following components in parts by weight: 8 parts of gallnut, 12 parts of phellodendron, 15 parts of dandelion, 8 parts of poria, 10 parts of wild chrysanthemum, 5 parts of ginseng, 4 parts of donkey-hide gelatin, 7 parts of sophora flavescens, 5 parts of Panax notoginseng, 10 parts of sanguisorba officinalis charcoal, 8 parts of lithospermum officinale, 10 parts of angelica sinensis, 7 parts of gardenia, 6 parts of calcined oyster shell and 3 parts of borneol.

9. A method for preparing the recombinant collagen dressing for treating hemorrhoids according to claim 8, characterized in that: The processing steps of the traditional Chinese medicine extract are as follows: weighing gallnut, phellodendron, dandelion, poria, wild chrysanthemum, ginseng, donkey-hide gelatin, sophora flavescens, Panax notoginseng, sanguisorba officinalis charcoal, lithospermum officinale, angelica sinensis, gardenia jasminoides, calcined oyster shell and borneol as needed; mixing the above raw material components and decocting them with water for 1 hour, wherein the amount of water added is 15 to 20 times the total weight of the raw materials; filtering the above traditional Chinese medicine liquid and concentrating the filtrate under reduced pressure, wherein the relative density of the filtrate after reduced pressure concentration is 0.9 to 1.0, and the pressure of reduced pressure concentration is 15 MPa, to obtain the traditional Chinese medicine extract.

10. The method for preparing the recombinant collagen dressing for treating hemorrhoids according to claim 9, characterized in that: Collagen is added to the traditional Chinese medicine extract and swelled completely to prepare a collagen mixture, which is then mixed with hydroxypropyl chitosan, hydroxybutyl chitosan, sodium alginate, low-fat pectin, antibacterial nano-silver powder, epidermal growth factor, and sodium hyaluronate to prepare a recombinant collagen dressing.

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