Reagent management system and method and sample analyzer

Abstract

The invention provides a reagent management system and method and a sample analyzer, and the system comprises a reagent loading module which comprises a cabin body used for accommodating a reagent container; the information storage parts are arranged on the reagent containers and used for bearing reagent information in the corresponding reagent containers; the information acquisition and transmission module is arranged corresponding to the accommodating area of each reagent container in the bin body, and is used for acquiring the reagent information in the corresponding information storage part and positioning the reagent container by scanning each accommodating area; the verification and information display consulting module is connected with the information acquisition and transmission module, and is used for updating the reagent information according to the reagent use condition after determining that the acquired reagent information is matched with the preset information of the corresponding accommodating area; and the updated content is written into the corresponding information storage component through the information acquisition and transmission module. According to the invention, the accuracy of reagent loading and the test efficiency can be effectively improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a reagent management system, method and sample analyzer. Background Art

[0002] With the continuous improvement of the automation level of medical devices, the fully automatic analyzers currently on the market mostly use automatic scanning and other methods in the human-machine interaction design of reagents and consumables. One method is to load the reagents into the reagent compartment, and install a barcode scanner in or near the reagent compartment. The reagent information is converted into a one-dimensional barcode according to certain coding rules and affixed to the reagent bottle. After the reagent is loaded, the barcode is read by the barcode scanner and the updated reagent information is automatically uploaded. Another method is to scan and load using radio frequency technology. The reagent information is pre-burned into the electronic label card. When loading the reagent, the corresponding type of reagent card is selected and swiped. After obtaining the information, the reagent information is parsed through a decryption method and automatically uploaded and updated.

[0003] However, existing reagent loading methods have high requirements on label quality and position, and the interactive process is complicated. Relying on manual labor will also lead to insufficient reagent loading accuracy, greatly affecting the efficiency of reagent loading and sample analysis. Summary of the Invention

[0004] In view of the above problems existing in the prior art, the present application proposes a reagent management system, method and sample analyzer, which mainly solve the problems of poor accuracy and efficiency of the existing reagent loading method.

[0005] In order to achieve the above-mentioned and other purposes, the technical solutions adopted by the present invention are as follows.

[0006] The present application provides a reagent management system, comprising: a reagent loading module, which includes a warehouse body for accommodating reagent containers; an information storage component, which is arranged on each reagent container and is used to carry reagent information in the corresponding reagent container; an information collection and transmission module, which is arranged corresponding to the accommodating area of ​​each reagent container in the warehouse body, and scans each accommodating area to collect reagent information in the corresponding information storage component and locate the reagent container; a verification and information display and review module, which is connected to the information collection and transmission module, determines that the collected reagent information matches the preset information of the corresponding accommodating area, updates the reagent information according to the reagent usage, and writes the updated content into the corresponding information storage component through the information collection and transmission module.

[0007] In one embodiment of the present application, the warehouse body includes an external reagent storage area, a dye reagent storage area and a specific protein reagent storage area.

[0008] In one embodiment of the present application, the specific protein reagent storage area is provided with a refrigeration module, which forms a refrigerated space in the specific protein reagent storage area, and the refrigerated space is isolated from the information collection and transmission module by an insulation layer.

[0009] In one embodiment of the present application, the dye solution reagent storage area includes a plurality of independent drawer-type card slots, and the reagent containers placed in the drawer-type card slots are connected to the sampling device through reagent needles and pipelines.

[0010] In one embodiment of the present application, the specific protein reagent storage area adopts a drawer-type structure, and the specific protein reagent storage area draws the protein reagent therein through independent reagent needles to perform sample testing.

[0011] In one embodiment of the present application, the information collection and transmission module includes a data reading end and multiple data detection ends, and the data reading end is connected to the data detection end through a disconnectable transmission channel, wherein the transmission channel is connected to the data detection end in a one-to-one correspondence, and the data detection end is arranged in a one-to-one correspondence with the accommodating area.

[0012] In one embodiment of the present application, the system further includes an alarm, which is connected to the verification and information display and review module. When the verification and information display and review module verifies that the reagent container loading position does not meet the preset positioning conditions or the reagent in the reagent container does not meet the preset usage conditions, an alarm message is generated, wherein the preset usage conditions are determined based on the shelf life of the reagent, the opening date, the opening validity period, the remaining number of uses of the reagent and / or the remaining usage amount of the reagent.

[0013] In one embodiment of the present application, the warehouse body is provided with a warehouse door, and the reagent needle is provided on the warehouse door. After the warehouse door is closed, the reagent needle penetrates the corresponding reagent container, and the penetration depth of the reagent needle is determined according to the remaining reagent in the corresponding reagent container.

[0014] In one embodiment of the present application, a telescopic assembly is further provided on the chamber door, and the telescopic assembly is connected to the reagent needle to control the reagent needle to extend to connect with the corresponding reagent container after the reagent container is loaded and verified.

[0015] In one embodiment of the present application, the verification and information display review module determines the sampling position of the sampling device according to the reagent remaining amount in the reagent container or the reagent expiration date.

[0016] The present application also provides a reagent management method, which is applied to a reagent management system, and the method includes: placing a reagent container in a warehouse; wherein the reagent container is provided with an information storage component for carrying reagent information; scanning the accommodating areas of each reagent container in the warehouse to collect reagent information in the corresponding information storage component and locate the reagent container; after determining that the collected reagent information matches the preset information of the corresponding accommodating area, updating the reagent information according to the reagent usage and writing the updated content into the corresponding information storage component.

[0017] In one embodiment of the present application, the step of scanning the accommodating areas of each reagent container in the chamber includes: scanning each accommodating area in a polling manner, and when an information storage component is detected in the corresponding accommodating area, determining that the reagent container is normally positioned.

[0018] In one embodiment of the present application, before updating the reagent information according to the reagent usage, it also includes: determining the reagent remaining amount by reading the reagent information in the information storage component; determining the lowering height of the reagent needle according to the reagent remaining amount, so as to absorb the reagent through the reagent needle for sample testing.

[0019] The present application also provides a reagent management method, which is applied to a reagent container end, and the method includes: placing a reagent container in a chamber for use in sample testing; wherein the reagent container is provided with an information storage component that carries reagent information; the information storage component receives and stores updated reagent information, wherein the updated reagent information is determined according to the reagent usage.

[0020] In one embodiment of the present application, after the reagent container is placed in the warehouse, it also includes: through the interaction of the information storage component and the information collection and transmission module in the warehouse, the reagent management system matches the reagent information in the information storage component with the preset information of the corresponding reagent container accommodating area to complete the positioning of the reagent container.

[0021] In one embodiment of the present application, the reagent types carried in the reagent container include external reagents, dye reagents and specific protein reagents. The reagent containers carrying different reagent types are placed in different areas of the warehouse body so that the sampling device can be docked with the corresponding reagent container to perform sampling and perform sample testing.

[0022] In one embodiment of the present application, the reagent container is connected to the sampling device via a reagent needle and a pipeline at a corresponding position on the chamber body, wherein the penetration depth of the reagent needle is determined according to the remaining amount of reagent in the corresponding reagent container.

[0023] The present application also provides a sample analyzer, comprising the reagent management system, an aspirating device and a testing device; the reagent container in the reagent management system is connected to the aspirating device, and the aspirating device aspirates the reagent and mixes it with the sample in the testing device for testing.

[0024] As described above, the reagent management system, method, and sample analyzer proposed in this application have the following beneficial effects.

[0025] After the reagent container is loaded into the chamber, the present application automatically positions the reagent container by scanning each accommodating area to avoid misplacement of the reagent container; at the same time, the reagent information is compared with the preset information to ensure that the reagent is loaded into the desired position and the accuracy of the reagent loading is guaranteed; the reagent information in the information storage component is automatically updated according to the actual usage situation to ensure that the reagent situation can be accurately obtained each time it is used, reducing the workload of manual reagent loading and remaining amount entry, and improving the efficiency of sample analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a module diagram of a reagent management system in one embodiment of the present application.

[0027] Figure 2 This is a schematic diagram of the display of the reagent management interface in one embodiment of the present application.

[0028] Figure 3 This is a diagram of reagent loading and human-computer interaction execution in one embodiment of the present application.

[0029] Figure 4 This is a flow chart of a reagent management method in one embodiment of the present application.

[0030] Figure 5 This is a schematic diagram of the overall process of the reagent management method in another embodiment of the present application.

[0031] Figure 6 This is a flow chart of a reagent management method in another embodiment of the present application.

[0032] Figure 7 FIG. 1 is a schematic diagram of the structure of a sample analyzer in one embodiment of the present application.

[0033] Explanation of the accompanying figures: 01-reagent loading module; 02-information collection and transmission module; 03-verification and information query module; 04-information storage component; 05-reagent management system; 06-absorption device; 07-testing device. DETAILED DESCRIPTION

[0034] The following describes the embodiments of the present invention through specific examples. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments. The details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the following embodiments and features in the embodiments can be combined with each other unless they conflict.

[0035] It should be noted that the illustrations provided in the following embodiments are merely schematic illustrations of the basic concept of the present invention. Therefore, the illustrations only show components related to the present invention and are not drawn according to the number, shape, and size of components in actual implementation. In actual implementation, the type, quantity, and proportion of each component may be changed arbitrarily, and the component layout may also be more complex.

[0036] The inventors have discovered that:

[0037] The reagent loading solution based on one-dimensional barcode is mostly used in fully automatic analyzers with a large number of reagent types. It can identify multiple reagent information at one time and is efficient and convenient. However, there are problems such as the centralized and fixed storage location of reagents, the expensive scanner, the high installation and positioning accuracy requirements of the scanner, the need to place the reagents at a specific angle when loading, and the barcode printing quality requirements. For reagents that need to be refrigerated, the waterproofness of the barcode and the defogging measures of the scanner mirror must also be considered, which further increases the design difficulty and material costs. The reagent loading solution based on electronic tags can realize closed management of reagents and has high security. However, when there are many types of reagents, the operation is cumbersome, which increases the number of interactions between users and analyzers. Customers need to manage a large number of reagent cards. At the same time, there is the problem of not being able to locate the storage location of the reagents and whether the loading is in place. For mid-to-high-end hematology analyzers, existing reagent loading devices and management methods often cannot effectively solve user experience and interaction problems. There are many types of reagents, and the locations of reagent bins are scattered. The use of barcode scanners increases costs and installation restrictions. Fluorescent dye reagents are directly connected to the pipeline after loading using radio frequency card swiping. Loading errors, misplacement, and under-positioning problems cannot be identified after swiping the card for loading; reagents that need to be refrigerated (protein reagents) also have loading positioning problems after swiping the card. Unused reagents cannot be loaded again after being transferred to the refrigerator for refrigeration by the instrument; at the same time, when loading reagents, the type of reagent to be loaded needs to be selected in turn. Users need to swipe the card multiple times and manage reagent cards of various specifications. The cumbersome human-computer interaction links and large amounts of material storage make it easy for the loaded reagents to not match the entered information, seriously affecting user experience and work efficiency.

[0038] Based on the problems existing in the above existing solutions, this application proposes a reagent management system, method and sample analyzer. The technical solution of this application is described in detail below with reference to specific embodiments.

[0039] See also Figure 1 , Figure 1 : This is a module diagram of the reagent management system in one embodiment of the present application. The reagent management system provided in the embodiment of the present application includes a reagent loading module 01, an information storage component 04, an information collection and transmission module 02, and a verification and information display and reference module 03. The reagent loading module 01 includes a warehouse and a base. The base is arranged inside the whole machine, and the warehouse is supported by the base. A plurality of accommodating areas for placing reagent containers are provided in the warehouse. The internal space of the warehouse can be divided into multiple storage areas according to the storage requirements of different reagents. The storage area includes an external reagent storage area, a dye reagent storage area and a specific protein reagent storage area. Of course, the internal space of the warehouse can also be divided into more storage areas according to actual storage requirements. The number of specific storage areas and the type of reagents stored can be designed and adjusted according to actual application requirements, and are not limited here. Here, the technical solution of the present application is described using only three storage areas as an example, which should not be regarded as a limitation to the present application. The three storage areas are designed to adapt to the storage and loading requirements of different types of reagents. Reagent bottles for diluents, hemolytic agents, and other reagents typically have large capacities and can be stored at room temperature. These reagent containers can be loaded into an external reagent storage area. This external reagent storage area can adopt an open design, allowing large-capacity, limited-variety, and infrequently replaced reagent containers to be placed in the external reagent storage area. Other reagents with smaller capacities, a wider variety, and frequent replacement can be placed in the internal storage area. This design approach allows for a more compact instrument design. The information acquisition and transmission module 02 can be mounted and fixed to the front of the instrument housing. Since the reagent containers in the external reagent storage area are all equipped with an information storage component 04, the information acquisition and transmission module 02 can be mounted and fixed to the front of the instrument housing. By scanning the reagent information in the information storage component 04, the reagent to be replaced can be accurately loaded. Dye and protein reagents typically have smaller capacities and are used at room temperature. The dye reagent storage area can store the dye reagent at room temperature; protein reagents, on the other hand, require low-temperature refrigeration and are stored in the refrigerated reagent compartment.

[0040] In one embodiment, the dye reagent storage area can include a plurality of independent drawer-type drawer slots, that is, each drawer slot can be relatively independently extracted or closed, and a dye reagent container can be placed in each drawer slot.Wherein the container of the dye reagent can be a reagent bag, and the reagent bag is placed in the drawer-type drawer slot, and the bag opening is towards the end of the drawer slot. The information storage unit 04 can be arranged at the bag opening position of each reagent bag, and the information collection and transmission module 02 is just opposite the drawer slot end to collect the reagent information in the information storage unit 04. The reagent bag bag opening position in the drawer-type drawer slot can be pierced by a reagent needle, and the dye reagent in the reagent bag is extracted by pump valve and pipeline to mix with the sample, and then the sample analysis test is carried out. The dye reagent storage area can be provided with a corresponding warehouse door, and the reagent needle can be installed on this warehouse door, and the reagent needle pierces the corresponding reagent bag along with the closing of the warehouse door.

[0041] In one embodiment, a refrigeration module is provided within the specific protein reagent storage area. The refrigeration module transfers heat from the specific protein reagent storage area to the external environment via heat dissipation channels within the device, thereby maintaining a low-temperature environment within the specific protein reagent storage area, thereby forming a refrigerated space for refrigerating the protein reagent. The refrigeration module can be made of a semiconductor material with heat absorption capabilities, or other mature refrigeration products, without limitation.

[0042] In one embodiment, the information collection and transmission module 02 can be located in the rear wall of the specific protein reagent storage area. Plastic POM panels can be encapsulated on both sides of the module, with a thermal insulation layer interposed between them. This insulation layer isolates the module from the refrigerated space of the specific protein reagent storage area, thereby reducing the impact of condensation on the module.

[0043] In one embodiment, the specific protein reagent storage area can also be configured as a drawer-type structure. After the specific protein reagent storage area is drawn out, the protein reagent container is placed into the specific protein reagent storage area, and then the specific protein reagent storage area is closed. Multiple protein reagent containers can be placed in the specific protein reagent storage area at the same time. Each protein reagent container uses an independent reagent needle to draw reagent, and the drawn reagent is introduced into the container containing the sample through an independent pipeline for testing.

[0044] In one embodiment, the information collection and transmission module 02 may include a data reader and a plurality of data detection terminals. The data reader is connected to each data detection terminal through a data transmission channel. The data detection terminal is provided with a one-to-one correspondence with the accommodating area inside the chamber in the reagent loading module 01. Each data detection terminal is opposite to an accommodating area, so as to form a data detection terminal arranged in an array. Each data detection terminal is used to detect whether the corresponding accommodating area has an information storage component 04. If so, the reagent container is in place or / and loaded into place. The reagent information in the information storage component 04 is sent to the data reader through the data transmission channel by the data detection terminal. Each data detection terminal corresponds to a data transmission channel, and each data transmission channel can be controlled by a switch. After the reagent container is placed in the chamber, the corresponding data transmission channel is selectively opened. The radio frequency signal of the information storage component 04 is detected by the data detection terminal of the corresponding position, and then the carrier information carrying the reagent information is sent to the data reader. The data reader decrypts and resolves the data to obtain the corresponding reagent information. Wherein the data reading end can be a controller, such as microprocessor (Micro-control Unit, MCU) etc., and the number of data transmission channels can be expanded and adjusted according to the number of accommodating areas in the bin body specifically, and is not restricted here.Select polling scanning mode during use, the controller opens the data transmission channel in sequence, accurately identifies the presence or absence of the reagent of the corresponding channel and the loading information, and obtains the presence or absence of the reagent of all data transmission channels and the loading information with this. After the data detection end detects the information storage component 04, a prompt tone can be output. The data reading end can upload the reagent information read to the verification and information display query module. The verification and information display query module can call the preset information of each accommodating area stored in advance and the reagent information uploaded by the data reading end are compared, judge whether the reagent container currently placed on the accommodating area matches the reagent container type of the expected putting into, if matching, the reagent container is loaded correctly.

[0045] In one embodiment, the verification and information query module can be connected to the central processing unit, and the data reading end uploads the read reagent information to the central processing unit for storage. When verification and query are required, the corresponding reagent information and the preset information of the accommodating area can be called from the central processing unit through the verification information query module for matching.

[0046] In one embodiment, the reagent management system also includes an alarm module. The data detection end can interact with the information storage component 04 through a radio frequency signal. The relative distance between the data detection end and the reagent container can be determined based on the response time of the radio frequency signal, and then it can be determined whether the reagent container is underfilled. When underfilled, an alarm is issued through the alarm module, and an alarm message is generated. The alarm message may include measures for handling underfilled reagents, etc. The alarm module may include conventional alarm devices such as an audible and visual alarm, and may also display an alarm message through a display device such as a display screen. When the reagent information read by the data reading module does not match the preset information, an alarm may also be activated through the alarm module, and an alarm message may be displayed.

[0047] In one embodiment, each information storage component 04 has a unique physical address, which uniquely identifies the reagent. The information within the information storage component 04 can be partitioned to create a fixed information storage area, a rewritable information storage area, and a marking information verification area. The fixed information storage area stores basic reagent information, including but not limited to reagent type and name, production date, shelf life, production batch number, specifications, and storage information. The rewritable information storage area stores reagent loading date, bottle expiration date, remaining quantity, loading information, and bottle number information, accurately recording reagent usage. The marking information verification area stores reagent placement area, placement location, availability, loading and reading verification codes, etc., to avoid reagent waste caused by reagent loading errors.

[0048] In one embodiment, after completing the verification to determine that the reagent container is correctly placed, the verification and information display and review module can send the reagent loading date, opening validity period, remaining information, loading information, bottle number information, usage status and other information to the data reading end through the central controller, and transmit the corresponding data to the data detection end through the data reading end, and use the carrier to write the corresponding data into the information storage component 04 at the corresponding position to complete the rewriting and updating of the reagent information in the information storage component 04.

[0049] In one embodiment, a reagent needle and pipeline, in conjunction with a pump valve, draw reagent from a corresponding reagent container to react with the sample to complete the test. After each test, the reagent remaining in the corresponding reagent container will change. The reagent remaining after each test can be calculated based on the amount of reagent drawn and the original amount of reagent in the reagent container, and the reagent remaining information is written to the information storage component 04 of the corresponding reagent container. Simultaneously, the reagent information is displayed on the display interface. The information collection and transmission module 02 can obtain information such as the reagent status, location, and reagent to be loaded. It dynamically adjusts and rewrites the data in the information storage component 04 based on the reagent usage, accurately recording the reagent remaining and usage.

[0050] In one embodiment, the alarm is connected to the verification and information display review module 03. When the verification and information display review module 03 verifies that the reagent container loading position does not meet the preset positioning conditions or the reagent in the reagent container does not meet the preset usage conditions, an alarm message is generated, wherein the preset usage conditions are determined based on the shelf life of the reagent, the opening date, the opening validity period, the remaining number of uses of the reagent and / or the remaining usage amount of the reagent.

[0051] Specifically, the effective use period of the reagent, the reagent production date and the shelf life limit the first available range of the reagent, and the opening date and the opening validity period limit the second available range of the reagent. For the reagent loaded for the first time, if the opening date and the opening validity period are within the shelf life, the effective use period of the reagent is the opening validity period, and it is allowed to be used; if the opening date is within the shelf life and the opening validity period is outside the shelf life, the effective use period of the reagent is the shelf life, and at the same time, it is prompted that the shelf life is approaching and it needs to be used up as soon as possible, and it is allowed to be used; if the opening date is outside the shelf life, it is prompted that the reagent is expired and its use is restricted; for the reagent not loaded for the first time, the reagent validity period has been determined and written into the reagent bottle, and the reagent usable period is within the opening validity period, and its use is restricted if it exceeds the expiration date;

[0052] The information on the remaining usage of the reagent records the availability of the reagent. When the remaining number of times the reagent is available is less than 1 time or the remaining usage is less than the set threshold, the usage is restricted; the information on the remaining usage of the reagent deducts the number of times or the usage in sequence as the usage occurs, and the information is synchronously updated in the information storage component 04; the user can set the information prompt threshold, and when the remaining number of times or the remaining usage of the reagent is less than a certain threshold, the system can calculate and plan the reagent usage in advance before applying for the test. If the number of applications is less than the remaining number, no prompt is required. When the number of applications is greater than the remaining number, an alarm prompt is required; when there is no available reagent on the machine for the applied test, the corresponding test item is locked, and an alarm prompts that there is no available reagent to be loaded.

[0053] See also Figure 2 , Figure 2Schematic diagram of the display of the reagent management interface in one embodiment of the present application. In one embodiment, the verification and information display query module generates corresponding reagent display information according to the reagent loading situation. For the operating instructions of the automatic loading reagent, the information storage component 04 on the reagent of each accommodating area is read in turn by polling mode to obtain all the information of the reagent to be loaded and to verify. The reagent information of the qualified reagent is updated and displayed on the reagent management interface. The reagent in the machine is kept without information update. For the specified reagent loading instruction operation, the information of the reagent to be loaded is obtained and verified by reading the label on the reagent at the specified position. The qualified reagent is updated and displayed on the reagent management interface. The reagent management interface can display the accommodating area and distribution of different types of reagents. The accommodating area of ​​dye reagent, external reagent and protein reagent can be displayed exemplarily. Clicking any of the accommodating areas can display the reagent information in the corresponding reagent container in the interface. The display content of the specific reagent information can be set and adjusted according to the actual application requirements, and is not limited here. A plurality of optional buttons can also be set in the reagent management interface. The corresponding action can be performed by selecting the corresponding button. The exemplified button can include operations such as reagent loading, unloading or cancellation.

[0054] In one embodiment, the warehouse body also includes a warehouse door, and the reagent needle is arranged on the warehouse door. After the warehouse door is closed, the reagent needle penetrates the corresponding reagent container, and the penetration depth of the reagent needle can be determined according to the reagent residual amount in the reagent container. Specifically, the reagent information stored in the information storage component 04 may include the reagent bottle specifications and residual information. After the reagent is loaded, the reagent needle descends and the height can be dynamically adjusted with the reagent residual amount during the test. If the needle is too shallow, insufficient reagent will be added. If the needle is too deep, residual reagent will remain on the outer wall of the needle. The height of the needle will affect the accuracy of the test result. After the reagent is loaded, the central controller can obtain the residual amount and specification size information of the protein reagent bottle through the information storage component 04. Before each reagent aspiration, the reagent liquid level in the reagent bottle can be converted to the height of the bottle bottom by using the reagent residual information and the reagent bottle specifications. The optimal descending height of the reagent needle is calculated accordingly. After the sample is aspirated, the reagent residual amount is updated to the information storage component 04. The next time the reagent is added, the calculation is performed again accordingly to solve the adverse effects of the reagent addition.

[0055] In one embodiment, a telescopic assembly is also provided on the chamber door, and the telescopic assembly is connected to the reagent needle. In the initial state, the telescopic assembly is in a retracted state, and the reagent needle is retracted to avoid contact with the reagent container. After the reagent container is loaded and checked, the reagent needle is controlled to extend to connect with the corresponding reagent container.

[0056] In one embodiment, taking dye reagent loading as an example, the dye reagent loading process retains the manual closing design of the chamber door, and the dye reagent needle is connected to the chamber door. The chamber door is closed after the reagent is loaded correctly to ensure the accuracy of reagent loading and avoid contamination of the reagent needle due to reagent loading errors.

[0057] In one embodiment, the verification and information display and review module 03 is used to analyze and process the data in the verification information area within the information storage component 04, making it convenient for users to promptly identify reagent availability issues in the early stages of reagent loading. On the verification and information display and review module 03, key information such as the type, remaining amount, expiration date, and batch number of various reagents on the instrument are recorded. Clicking a specific reagent icon can view more detailed reagent parameter information. At the same time, the reagent management interface can clearly display the status of the reagents on the machine, realizing real-time monitoring of the reagents. Insufficient reagent remaining amount will be prompted and warned by the reagent icon and background color, and the unloaded reagent area will be marked with a reagent empty information, making it convenient for users to manage the reagents.

[0058] See also Figure 3 , Figure 3 The figure is a flow chart of human-computer interaction in one embodiment of the present application. The process of human-computer interaction includes the following steps:

[0059] Step S301: The signal detector scans the label on the reagent bottle, obtains the reagent information in the label and sends it to the card reader, wherein the reagent bottle is connected to the reagent suction device. Specifically, during the test, the reagent suction device sucks the reagent in the corresponding reagent bottle through the reagent needle to react with the sample.

[0060] In step S302, the card reader uploads the received actual information to the central controller, which then verifies the reagent information and assesses its availability. Specifically, the card reader uploads the reagent information to the central controller for verification and availability assessment. The central controller then displays and schedules the information, managing reagent scheduling through user interaction (e.g., clicking on "Load Reagent," "Change Reagent," and other actions in the display interface).

[0061] In step S303, the central controller checks the reagent bottle's remaining level based on actual usage and rewrites the information on the corresponding reagent bottle label via a signal detector. Specifically, each reagent bottle can be connected to a reagent aspiration device. During sample testing, the reagent aspiration device can feedback the aspiration amount to the central controller. The central controller calculates the current reagent remaining level in the reagent bottle based on the reagent information read from the label and the reagent aspiration amount. The central controller then transmits the reagent remaining level to the card reader, and the reagent information on the label is rewritten via the card reader and signal detector.

[0062] Based on the above technical solutions of the present application, the information acquisition and transmission module 02 is designed in a manner that the data reading end and the data detection end are separated. The data transmission channel can be expanded on the data detection end, and the data detection end is expanded and configured according to the spacing between the reagent bottles, the detection distance, and the maximum reagent loading quantity of the reagent bin, which has great advantages in the design of multi-reagent bin layout. Compared with the original reagent card swiping method, the reagent loading solution can realize automatic reagent loading and scanning. In the application scenarios with more and more types of reagents, it solves the problem of long waiting time for users to load reagents and cumbersome operations leading to low efficiency. At the same time, it solves the problem of mismatch between the actual loaded reagents and the expected loaded reagents caused by the limitations of the user's physical functions and memory, and improves the accuracy of reagent information loading. Positioning the reagent container through the signal acquisition and transmission module can reduce the number of sensors and reduce costs. It can also detect problems such as reagent loading misalignment and under-positioning. Reagents that have been loaded on the machine can be unloaded and then reloaded, and the reagent remaining information will be refreshed synchronously; after loading is completed, the stored reagent information can be automatically scanned and updated to reduce the frequency of interaction and improve the efficiency of loading and testing; by automatically refreshing and storing the reagent information on the machine, it is convenient to observe the reagent loading status and reagent remaining information and other key information during the use of the instrument; it can realize non-sensing reagent loading, and the reagent information reading and refresh speed can be improved through the radio frequency array scanning method.

[0063] See also Figure 4 , Figure 4 The figure is a flow chart of a reagent management method in one embodiment of the present application. The reagent management method of the present application comprises the following steps:

[0064] Step S400: placing a reagent container in the chamber; wherein the reagent container is provided with an information storage component 04 for carrying reagent information;

[0065] Step S410, scanning the accommodating areas of each reagent container in the chamber to collect the reagent information in the corresponding information storage component 04 and locate the reagent container;

[0066] Step S420 : After determining that the collected reagent information matches the preset information of the corresponding accommodation area, the reagent information is updated according to the reagent usage, and the updated content is written into the corresponding information storage component 04 .

[0067] Specifically, see Figure 5 The specific steps of the reagent loading process include:

[0068] Step S500: Place the reagents to be loaded in the target reagent compartment; different types of reagents are placed in different target reagent compartments, where the target reagent compartments may include an external reagent compartment, a dye reagent compartment, a specific protein reagent compartment, etc.

[0069] In step S510, the information acquisition and transmission module 02 obtains the information carried by the information storage component 04 on the reagent bottle according to the storage area, storage position, and storage status of the loaded reagent; the information acquisition and transmission module 02 may include a card reader and a signal detector. The card reader may be connected to multiple signal detectors through a disconnectable channel. The signal detectors are set in a one-to-one correspondence with the accommodating areas of the reagent bottles. The reagent information carried in the information storage component 04 in the corresponding area is collected by the signal detector, and the actual information is sent to the card reader for analysis and processing.

[0070] Step S520, verify the accuracy, availability, and authorization of the reagent loading information, and successfully obtain the correct information of the reagent to be loaded; the card reader will send the obtained reagent information to the central controller, and the central controller will perform relevant verification actions.

[0071] Step S530: Load the reagent information into the reagent management system interface and record the reagent remaining information. The central controller will display the verification results and the latest reagent information on the reagent management system interface. At the same time, the central controller will also receive the reagent aspiration amount from the reagent aspiration device to facilitate reagent remaining monitoring.

[0072] The reagent usage process includes the following steps:

[0073] Step S540: Evaluate the reagent remaining amount according to the submitted test items, and start the test normally if the remaining amount is sufficient. When the reagent is needed, submit the test item, and call the actual information of the current corresponding reagent bottle recorded on the system end according to the test item for evaluation. If the test requirements are met, start the test normally. Otherwise, output an alarm message to remind relevant personnel to load the reagent, etc.

[0074] Step S550, planning the reagent aspirating device to take the reagent from the designated position according to the reagent status and the reagent remaining amount; after starting the test, the reagent aspirating device can be controlled to connect to the reagent bottle at the designated position for sampling. For example, the penetration depth of the sampling needle can be controlled according to the reagent remaining amount.

[0075] Step S560, update the reagent remaining amount according to the actual amount taken by the test item and re-update the relevant information into the information storage component 04. After completing the information update, return to step S530 and display the updated content on the reagent management system interface so that relevant personnel can view the reagent information.

[0076] In one embodiment, the step of scanning the accommodating areas of each reagent container in the chamber includes: scanning each accommodating area in a polling manner, and determining that the reagent container is normally positioned when the information storage component 04 is detected in the corresponding accommodating area. Specifically, the data detection terminals in the information acquisition and transmission module 02 are arranged in an array, one-to-one with the information storage component 04 in spatial position, and a switch is provided on the data detection terminal to open or close the data transmission channel connected to the data detection terminal. When the data detection terminal is used, a polling scanning mode is selected. The controller of the data reading terminal sequentially opens the data transmission channels of the data detection terminal in sequence, and the presence or absence of reagents and loading information corresponding to all data transmission channels are obtained. Selecting a designated data transmission channel for scanning can accurately identify the presence or absence of reagents and loading information of the corresponding channel.

[0077] The process of using reagents for testing includes: evaluating the reagent remaining amount according to the submitted test items, starting the test normally when the remaining amount is sufficient, planning the reagent suction device to suck the reagent to the designated position according to the reagent status in the machine and the reagent remaining amount; updating the reagent remaining amount according to the amount of reagent taken for the test item and updating the relevant information to the information storage component 04, and loading the updated reagent information to the reagent management system interface.

[0078] In one embodiment, before updating the reagent information according to the reagent usage, the process also includes: determining the reagent remaining amount by reading the reagent information in the information storage component 04; and determining the descending height of the reagent needle according to the reagent remaining amount, so as to absorb the reagent through the reagent needle for sample testing.

[0079] Specifically, the user loads the reagent into the corresponding reagent storage area. The reagent information is stored in the information storage component 04, which is packaged with the reagent bottle. Closing the reagent compartment door or tapping the reagent loading interface initiates the loading process. The software system receives the loading completion signal sent by the sensor and starts reading the reagent information. The information acquisition and transmission module 02 uploads the reagent information to the central controller, which then loads the reagent information into the instrument reagent management interface, which displays the reagent information parameters. After loading, the reagent is supplied to the instrument for testing via the aspiration device. During the test, if key information such as the remaining amount of the reagent changes after use, the reagent information loading module 01 is again linked, and information such as the remaining amount is recorded in the information storage component 04. For system scheduling, under restrictions such as the reagent's usable period and the reagent remaining amount, the use of over-limit reagents will be restricted. When assembling multiple bottles of the same reagent, scheduling is carried out based on the reagent's expiration date, giving priority to reagents with a shorter expiration date. The corresponding reagent aspiration position is also dynamically adjusted. For test items that require dynamic adjustment of the aspiration position based on the remaining amount, the needle height is calculated based on the amount used and the remaining amount before aspiration to prevent the reagent aspiration device from being immersed in a deep contamination of the reagent.

[0080] See also Figure 6 , Figure 6 This is a flow chart of a reagent management method according to another embodiment of the present application. The method is applied to the reagent container end and specifically includes the following steps:

[0081] Step S600: a reagent container is placed in the chamber for use in sample testing; wherein the reagent container is provided with an information storage component 04 carrying reagent information;

[0082] Specifically, the warehouse body may include multiple areas for placing different reagent types. For example, the warehouse body may be divided into an external reagent area, a dye reagent area, and a specific protein reagent area. Reagent containers can be placed in corresponding reagent areas according to their actual types. Each reagent container is equipped with an information storage component 04, which records the reagent information in the corresponding reagent container. The reagent information includes reagent type, reagent remaining amount, reagent container specifications, etc. The specific reagent information can be adjusted according to actual application and is not limited here.

[0083] In one embodiment, after the reagent container is placed in the warehouse, the system further comprises: interacting with the information collection and transmission module 02 in the warehouse through the information storage component 04, so that the reagent management system end matches the reagent information in the information storage component 04 with the preset information of the corresponding reagent container accommodating area, thereby completing the reagent container positioning. Specifically, the information collection and transmission module 02 may include a card reader and a signal detector. A signal detector may be provided in the accommodating area of ​​each reagent container to collect the reagent information in the information storage component of the corresponding area. The card reader is connected to each signal detector through a switchable signal path. The signal detector can obtain a carrier wave carrying the reagent information through a radio frequency signal, and the carrier wave is sent to the card reader for parsing to obtain the reagent information. The card reader can send the reagent information to the central controller, which can pre-set the expected storage reagent information of each accommodating area. The reagent information currently read is compared with the preset information to determine whether the reagent container is placed in the correct position, thereby completing position positioning and verification.

[0084] In one embodiment, the sampling device can be connected to the chamber body. After the chamber body is closed, the sampling device can use a sampling needle to manage the reagent container connected to the corresponding position. The penetration depth of the sampling needle can be determined according to the remaining reagent in the current reagent container.

[0085] In step S610, the information storage component 04 receives and stores updated reagent information, wherein the updated reagent information is determined according to the reagent usage.

[0086] Specifically, the sampling device will feed back the sampling volume each time to the central controller, so that the central controller calculates the remaining amount in the reagent container after sampling based on the sampling volume and the read reagent information, and then writes the remaining information into the corresponding information storage component 04 through the signal detector to complete the reagent information update.

[0087] See also Figure 7 , Figure 7 This is a schematic diagram of the architecture of a sample analyzer in one embodiment of the present application. The present application also provides a sample analyzer, which includes the aforementioned reagent management system 05, an aspirating device 06, and a testing device 07. The reagent container in the reagent management system 05 is connected to the aspirating device 06, and the reagent is aspirated by the aspirating device 06 and mixed with the sample in the testing device 07 for testing. The aspirating device 06 may include a plurality of pumps and valves, which control the pressure difference in the corresponding pipelines to aspirate the reagents in the connected reagent containers. The testing device 07 can be used as a container for holding samples, or a platform for accommodating samples. It can be specifically designed and adjusted according to actual product requirements. As long as it can facilitate the reaction between the reagent and the sample, there is no limitation here.

[0088] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the present invention. Anyone skilled in the art may modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by one of ordinary skill in the art without departing from the spirit and technical principles disclosed herein are intended to be covered by the claims of the present invention.

Claims

1. A reagent management system, characterized in that: include: A reagent loading module, comprising a chamber for accommodating a reagent container; An information storage component, which is provided on each reagent container and is used to carry the reagent information in the corresponding reagent container; An information collection and transmission module is provided corresponding to the accommodating area of ​​each reagent container in the chamber, and collects reagent information from the corresponding information storage component and locates the reagent container by scanning each accommodating area; The verification and information display and review module is connected to the information collection and transmission module. After determining that the collected reagent information matches the preset information of the corresponding accommodating area, the reagent information is updated according to the reagent usage, and the updated content is written into the corresponding information storage component through the information collection and transmission module.

2. The reagent management system according to claim 1, characterized in that: The warehouse body includes an external reagent storage area, a dye reagent storage area and a specific protein reagent storage area.

3. The reagent management system according to claim 2, characterized in that: The specific protein reagent storage area is provided with a refrigeration module, which forms a refrigerated space in the specific protein reagent storage area. The refrigerated space is isolated from the information collection and transmission module by a heat preservation layer.

4. The reagent management system according to claim 2, characterized in that: The dye solution reagent storage area includes a plurality of independent drawer-type card slots, and the reagent containers placed in the drawer-type card slots are connected to the sampling device through reagent needles and pipelines.

5. The reagent management system according to claim 2 or 3, characterized in that: The specific protein reagent storage area adopts a drawer-type structure, and the specific protein reagent storage area draws the protein reagent therein through an independent reagent needle to perform sample testing.

6. The reagent management system according to claim 1, characterized in that: The information collection and transmission module includes a data reading end and multiple data detection ends. The data reading end is connected to the data detection end through a disconnectable transmission channel, wherein the transmission channel is connected to the data detection end in a one-to-one correspondence, and the data detection end is arranged in a one-to-one correspondence with the accommodating area.

7. The reagent management system according to claim 1, characterized in that: The system also includes an alarm, which is connected to the verification and information display and review module. When the verification and information display and review module verifies that the reagent container loading position does not meet the preset positioning conditions or the reagent in the reagent container does not meet the preset usage conditions, an alarm information is generated, wherein the preset usage conditions are determined based on the shelf life of the reagent, the opening date, the opening expiration date, the remaining number of uses of the reagent and / or the remaining usage amount of the reagent.

8. The reagent management system according to claim 4 or 5, characterized in that: The chamber body is provided with a chamber door, and the reagent needle is provided on the chamber door. After the chamber door is closed, the reagent needle penetrates into the corresponding reagent container, and the penetration depth of the reagent needle is determined according to the reagent remaining amount in the corresponding reagent container.

9. The reagent management system according to claim 4 or 5, characterized in that: The chamber door is further provided with a telescopic assembly, which is connected to the reagent needle to control the reagent needle to extend and connect with the corresponding reagent container after the reagent container is loaded and verified.

10. The reagent management system according to claim 4, characterized in that: The verification and information display and review module determines the sampling position of the sampling device according to the reagent remaining amount in the reagent container or the reagent expiration date.

11. A reagent management method, characterized in that: Applied to the reagent management system, the method includes: A reagent container is placed in the chamber; wherein the reagent container is provided with an information storage component for carrying reagent information; Scanning the accommodating areas of the reagent containers in the chamber to collect the reagent information in the corresponding information storage component and locate the reagent containers; After determining that the collected reagent information matches the preset information of the corresponding accommodating area, the reagent information is updated according to the reagent usage, and the updated content is written into the corresponding information storage component.

12. The reagent management method according to claim 11, characterized in that: The step of scanning the accommodating areas of the reagent containers in the chamber includes: Each accommodating area is scanned in a polling manner, and when it is detected that an information storage component exists in the corresponding accommodating area, it is determined that the reagent container is normally positioned.

13. The reagent management method according to claim 11, characterized in that: Before updating the reagent information according to the reagent usage, the method further includes: Determining the remaining amount of the reagent by reading the reagent information in the information storage component; The descending height of the reagent needle is determined according to the remaining amount of the reagent, so as to absorb the reagent through the reagent needle to perform sample testing.

14. A reagent management method, characterized in that: Applied to the reagent container end, the method comprises: The reagent container is placed in the chamber for use in sample testing; the reagent container is provided with an information storage component carrying reagent information; The information storage component receives and stores updated reagent information, wherein the updated reagent information is determined according to the reagent usage.

15. The reagent management method according to claim 14, characterized in that: After the reagent container is placed in the warehouse, it also includes: through the interaction of the information storage component and the information collection and transmission module in the warehouse, the reagent management system matches the reagent information in the information storage component with the preset information of the corresponding reagent container accommodating area to complete the positioning of the reagent container.

16. The reagent management method according to claim 14, characterized in that: The reagent types carried in the reagent container include external reagents, dye reagents and specific protein reagents. Reagent containers carrying different reagent types are placed in different areas of the warehouse body, so that the sampling device can be docked with the corresponding reagent container to perform sampling and sample testing.

17. The reagent management method according to claim 16, characterized in that: The reagent container is connected to the sampling device via a reagent needle at a corresponding position on the chamber body and a pipeline, wherein the penetration depth of the reagent needle is determined according to the remaining amount of the reagent in the corresponding reagent container.

18. A sample analyzer, characterized in that: It comprises the reagent management system, suction device and testing device according to any one of claims 1 to 10; the reagent container in the reagent management system is connected to the suction device, and the reagent is sucked by the suction device and mixed with the sample in the testing device for testing.

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