Eye drop processing method and liquid mixing equipment

Abstract

The invention provides an eye drop processing method and liquid mixing equipment, belongs to the technical field of medicine processing, and aims to solve the problem that during processing of eye drops which are single in effect and rich in ingredients, each step of sterilization and filtration brings inconvenience to replacement of instruments and operation of production personnel. Mixing liquid, heating and dissolving, and the like. A used liquid mixing device comprises a liquid preparation tank and at least two dissolving tanks, a degerming table is arranged on two liquid preparation pipes, a rotating frame is rotationally arranged on the degerming table, a plurality of funnels are distributed on the circumference of the circumferential side of the rotating frame, a leakage opening communicated with the two liquid preparation pipes is formed in the degerming table, and the dissolving tanks are communicated with the two liquid preparation pipes. And liquid outlets of the liquid preparation tanks are distributed above the corresponding funnels.

Description

Technical Field

[0001] The present invention belongs to the technical field of drug processing, and more specifically, relates to an eye drop processing method and liquid mixing equipment. Background Art

[0002] With the rapid development of science and technology, people are exposed to electronic entertainment products for longer and longer periods of time. Long-term viewing of electronic screens can easily cause eye fatigue, leading to decreased vision or some eye diseases. Currently, eye drops are commonly used to maintain glasses and relieve fatigue. These eye drops have a single effect. However, with product development, the formula of eye drops has been upgraded, which not only relieves eye fatigue, but also has the effect of treating eye diseases. These eye drops are rich in ingredients in the processing, and the cleanliness of eye drops needs to be ensured during production. The sterilization and filtration of each step brings inconvenience to the replacement of equipment and the operation of production personnel.

[0003] Therefore, in view of this, the existing structure and defects are studied and improved, and an eye drop processing method and liquid mixing equipment are provided, in order to achieve a more practical purpose. Summary of the Invention

[0004] In order to solve the above technical problems, the present invention provides an eye drop processing method and liquid mixing equipment to solve the problem that ordinary eye drops have a single effect and rich ingredients, and each step of sterilization and filtration in the processing of eye drops brings inconvenience to the replacement of equipment and operation of production personnel.

[0005] The purpose and efficacy of the eye drop processing method and liquid mixing equipment of the present invention are achieved by the following specific technical means:

[0006] A method for processing eye drops, comprising the following steps:

[0007] S1. Pretreatment of the main drug: water-soluble drugs are dissolved by heating with an appropriate amount of water for injection, and fat-soluble drugs are dissolved by heating with a non-aqueous solvent, and then filtered and sterilized after dissolution;

[0008] S2: Pretreatment of excipients: dissolving osmotic pressure regulator, pH regulator, antibacterial agent and thickener, and filtering and sterilizing;

[0009] S3: Add water for injection into the preparation tank and heat to 70-80°C;

[0010] S4: Add the pretreated auxiliary material solution into the liquid preparation tank in sequence and stir;

[0011] S5: Add the pretreated main drug solution and stir;

[0012] S6: Take samples to test the pH value. If the pH value reaches the range of 6.5-7.5 and the osmotic pressure reaches 280-320 mOsm / kg, the finished product is obtained.

[0013] Furthermore, in step S1, the water-soluble drugs are levofloxacin, tobramycin, and pilocarpine hydrochloride, which are dissolved in water for injection;

[0014] Lipid-soluble drugs are dexamethasone and prednisolone acetate, which are dissolved in propylene glycol.

[0015] The liquid mixing equipment used in the processing method includes a liquid mixing tank and at least two dissolving tanks. Two liquid mixing pipes are provided on the top of the liquid mixing tank, and a sampling port and a liquid discharge pipe are provided on one side of the liquid mixing tank. A sterilization table is provided on the two liquid mixing pipes. A rotating rack is rotatably provided on the sterilization table. A plurality of funnels are distributed circumferentially around the rotating rack. A leakage port connected to the two liquid mixing pipes is provided on the sterilization table. After the rotating rack is rotated, the bottoms of two of the funnels correspond to the leakage ports. The dissolving tank is connected to the liquid mixing tank through a bracket. The liquid outlets of the liquid mixing tank are distributed above the corresponding funnels.

[0016] Furthermore, heating pipes are distributed on the bottom of the dissolving tank and the inner wall of the liquid preparation tank, and the heating pipes are heated by an electrical box.

[0017] Furthermore, a leak-proof structure is provided between the funnel and the sterilization table, including a guide platform provided on the sterilization table corresponding to the position of the liquid distribution pipe, an active cavity connected to the liquid distribution pipe is passed through the guide platform and the sterilization table, a plug is slidingly provided at the bottom of the funnel, the plug is connected to the funnel through a spring, and the plug matches the size of the active cavity, and an ejection mechanism is provided in the active cavity.

[0018] Furthermore, the ejection mechanism includes a coupling sleeve slidingly arranged in the movable cavity, and sliding grooves are extended on both sides of the movable cavity, a horizontal axis is arranged in one of the sliding grooves, a gear is sleeved on the horizontal axis, and a sliding bar is arranged on the circumference of the coupling sleeve and is clamped in the sliding groove, wherein the sliding bar close to the gear is arranged as a rack that meshes with the gear.

[0019] Furthermore, inclined slopes are formed at both ends of the guide platform.

[0020] Furthermore, a rotating shaft is rotatably arranged in the liquid dispensing tank, one end of the rotating shaft is driven by a motor, and a stirring ring is arranged on the rotating shaft.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] Filtration and sterilization are frequently performed during the preparation process, and the funnel of the present invention can replace the 0.2 μm microporous filter membrane more quickly. The replaced filter membrane can be used by rotating the rotating rack, and the used filter membrane can be quickly replaced, which brings convenience to the preparation of eye drops. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a three-dimensional diagram of the liquid mixing device of the present invention.

[0024] Figure 2 It is an exploded view of the liquid mixing device of the present invention.

[0025] Figure 3 yes Figure 2 Magnified view of area A in center.

[0026] Figure 4 It is a front cross-sectional view of the liquid mixing device of the present invention.

[0027] Figure 5 It is a partial structural cross-sectional view of the present invention.

[0028] In the figure, the corresponding relationship between the component names and the drawing numbers is as follows:

[0029] 1. Liquid dispensing tank; 2. Liquid dispensing pipe; 3. Sterilization table; 4. Rotary rack; 5. Funnel; 6. Bracket; 7. Dissolving tank; 8. Liquid outlet; 9. Electric box; 10. Motor; 11. Rotary shaft; 12. Stirring ring; 13. Heating tube; 101. Sampling port; 102. Drain pipe; 103. Pump; 301. Movable cavity; 302. Guide table; 303. Slide; 304. Horizontal axis; 305. Coupling sleeve; 306. Rack; 307. Gear; 501. Plug; 502. Spring. DETAILED DESCRIPTION

[0030] The following embodiments of the present invention are described in further detail with reference to the accompanying drawings and examples. The following examples are used to illustrate the present invention but are not intended to limit the scope of the present invention.

[0031] In the description of the present invention, unless otherwise specified, "plurality" means two or more; terms such as "upper," "lower," "left," "right," "inner," "outer," "front end," "rear end," "head," and "tail" indicate positions or relationships based on those shown in the accompanying drawings. These terms are intended solely to facilitate the description of the present invention and simplify the description. They do not indicate or imply that the devices or components referred to must have a specific orientation, be constructed, or operate in a specific orientation. Therefore, they should not be construed as limiting the present invention. Furthermore, terms such as "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0032] In the description of the present invention, it should be noted that, unless otherwise expressly specified or limited, the terms "connected" and "connection" should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integral connection; mechanical connection, electrical connection; direct connection, or indirect connection through an intermediary. Those skilled in the art will understand the specific meanings of the above terms in the present invention based on the specific circumstances.

[0033] Example:

[0034] The present invention provides an eye drop processing method, comprising the following steps:

[0035] S1: Pretreatment of main drugs: levofloxacin, tobramycin, pilocarpine hydrochloride and other water-soluble drugs are heated and dissolved in an appropriate amount of water for injection;

[0036] Then, fat-soluble drugs such as dexamethasone and prednisolone acetate are dissolved by heating with propylene glycol, and then filtered and sterilized after dissolution;

[0037] S2: Pretreatment of excipients: dissolving osmotic pressure regulator, pH regulator, antibacterial agent and thickener, and filtering and sterilizing;

[0038] S3: Add water for injection into the preparation tank 1 and heat to 70-80°C;

[0039] S4: Add the pretreated auxiliary material solution into the liquid preparation tank 1 in sequence and stir;

[0040] S5: Add the pretreated main drug solution and stir;

[0041] S6: Take samples to test the pH value. If the pH value reaches the range of 6.5-7.5 and the osmotic pressure reaches 280-320 mOsm / kg, the finished product is obtained.

[0042] The eye drops prepared by this method are milder and safer, have a longer shelf life, and are also suitable for use with contact lenses.

[0043] The liquid mixing equipment used in the processing method of the eye drops is as follows: Figures 1 to 4 As shown, it includes a liquid dispensing tank 1 and at least two dissolving tanks 7. Two liquid dispensing pipes 2 are provided on the top of the liquid dispensing tank 1, and a sampling port 101 and a liquid discharge pipe 102 are provided on one side of the liquid dispensing tank 1. A rotating shaft 11 is rotatably provided in the liquid dispensing tank 1. One end of the rotating shaft 11 is driven by a motor 10. A stirring ring 12 is provided on the rotating shaft 11. The motor 10 can drive the rotating shaft 11 to rotate, thereby mixing and stirring the liquid in the liquid dispensing tank 1.

[0044] A sterilization table 3 is set on the two liquid dispensing pipes 2, and a rotating rack 4 is rotatably set on the sterilization table 3. A plurality of funnels 5 are distributed on the circumference of the rotating rack 4. The plurality of funnels 5 can rotate with the rotating rack 4. A leakage port connected to the two liquid dispensing pipes 2 is provided on the sterilization table 3. After rotating the rotating rack 4, the bottoms of the two funnels 5 correspond to the leakage ports. The funnel 5 is used to place a 0.22 μm microporous filter membrane. The dissolving tank 7 is connected to the liquid dispensing tank 1 through a bracket 6. The liquid outlet 8 of the liquid dispensing tank 1 is distributed above the corresponding funnel 5. The two dissolving tanks 7 are respectively used for dissolving the main drug and the auxiliary material. After dissolution, the liquid flows into the funnel 5 through the liquid outlet 8, and the filter membrane in the funnel 5 filters and sterilizes the liquid. The filtered and sterilized liquid is collected into the liquid dispensing tank 1 through the liquid dispensing pipe 2 for stirring and mixing;

[0045] After the eye drops are mixed and stirred to prepare them, samples can be taken through the sampling port 101, and the sampled samples are tested for pH value and osmotic pressure. If the pH value reaches the range of 6.5-7.5 and the osmotic pressure reaches 280-320mOsm / kg, they are pumped out through the pump 103 on the discharge pipe 102 and enter the filling process.

[0046] Heating is performed in both the dissolving tank 7 and the liquid preparation tank 1 to assist dissolution. Heating tubes are distributed on the bottom of the dissolving tank 7 and the inner wall of the liquid preparation tank 1, and the heating tubes are controlled by the electric box 9 to heat and assist dissolution.

[0047] Since filtration and sterilization are frequent during the liquid preparation process, the filter membrane needs to be replaced in real time. A leak-proof structure is set between the funnel 5 and the sterilization table 3 for filtration and sterilization. While filtering and sterilizing, it can also prevent liquid from leaking out, improve the cleanliness level, and reduce pollution. The leak-proof structure includes a guide platform 302 set on the sterilization table 3 corresponding to the position of the liquid preparation pipe 2. The guide platform 302 is arc-shaped and adapts to the edge of the sterilization table 3.

[0048] An active chamber 301 connected to the liquid distribution pipe 2 is provided between the guide platform 302 and the sterilization platform 3. A plug 501 is slidably provided at the bottom of the funnel 5. The plug 501 is connected to the funnel 5 by a spring 502. The plug 501 matches the size of the active chamber 301. Inclined slopes are formed at both ends of the guide platform 302. During the rotation of the rotating frame 4, the plug 501 at the bottom of the funnel 5 can always fit the sterilization platform 3. Before the funnel 5 is connected to the active chamber 301, it is squeezed and guided by the guide platform 302 so that the plug 501 is recovered into the bottom of the funnel 5. When the plug 501 just moves to the top of the active chamber 301, the spring 502 drives the plug 501 to be inserted into the active chamber 301, thereby realizing the positioning of the rotating frame 4, indicating that the replaced filter membrane has been rotated into place following the funnel 5.

[0049] It is necessary to adjust the new funnel 5 and place it below the liquid outlet 8 of the dissolving tank 7 so that when the filter membrane is replaced, an ejection mechanism is provided in the movable chamber 301. The ejection mechanism includes a combination sleeve 305 slidably provided in the movable chamber 301. Figure 3 and Figure 4When the filter membrane 501 is in the corresponding position, the spring 502 drives the plug 501 to extend into the active cavity 301 in a natural state. At this time, liquid leakage occurs. When the filter membrane needs to be replaced, a new filter membrane is placed in the unused funnel 5. The gear 307 is driven to drive the coupling sleeve 305 to rise, thereby squeezing the plug 501 out of the active cavity 301. After the plug 501 leaves the active cavity 301, the rotating frame 4 can be rotated to replace the funnel 5. The funnel 5 that leaves the corresponding position of the liquid outlet 8 can be used to replace the filter membrane without contaminating the solution being filtered and sterilized. The used filter membrane can be quickly replaced, which brings convenience to the preparation of eye drops.

[0050] The liquid outlet 8 and the sampling port 101 are both provided with valves.

[0051] The embodiments of the present invention are presented for purposes of illustration and description and are not intended to be exhaustive or to limit the invention to the disclosed forms. Many modifications and variations will be apparent to those skilled in the art. The embodiments are chosen and described in order to better illustrate the principles of the invention and its practical application and to enable those skilled in the art to understand the invention and design various embodiments with various modifications as suited for specific applications.

Claims

1. A method for processing eye drops, characterized in that: The steps include: S1: Pretreatment of the main drug: water-soluble drugs are dissolved by heating with an appropriate amount of water for injection, and fat-soluble drugs are dissolved by heating with a non-aqueous solvent, and then filtered and sterilized after dissolution; S2: Pretreatment of excipients: dissolving osmotic pressure regulator, pH regulator, antibacterial agent and thickener, and filtering and sterilizing; S3: Add water for injection into the preparation tank 1 and heat to 70-80°C; S4: Add the pretreated auxiliary material solution into the liquid preparation tank 1 in sequence and stir; S5: Add the pretreated main drug solution and stir; S6: Take samples to test the pH value. If the pH value reaches the range of 6.5-7.5 and the osmotic pressure reaches 280-320 mOsm / kg, the finished product is obtained.

2. The eye drop processing method according to claim 1, wherein: In step S1, the water-soluble drugs are levofloxacin, tobramycin, and pilocarpine hydrochloride, which are dissolved in water for injection; Lipid-soluble drugs are dexamethasone and prednisolone acetate, which are dissolved in propylene glycol.

3. The liquid mixing device used in the processing method according to claim 1, characterized in that: The invention comprises a liquid dispensing tank (1) and at least two dissolving tanks (7), wherein two liquid dispensing pipes (2) are provided on the top of the liquid dispensing tank (1), and a sampling port (101) and a liquid discharge pipe (102) are provided on one side of the liquid dispensing tank (1), a sterilization table (3) is provided on the two liquid dispensing pipes (2), a rotating rack (4) is rotatably provided on the sterilization table (3), a plurality of funnels (5) are distributed on the circumference of the rotating rack (4), a leakage port connected to the two liquid dispensing pipes (2) is provided on the sterilization table (3), and after the rotating rack (4) is rotated, the bottoms of two of the funnels (5) correspond to the leakage port, the dissolving tank (7) is connected to the liquid dispensing tank (1) through a bracket (6), and the liquid outlet (8) of the liquid dispensing tank (1) is distributed above the corresponding funnel (5).

4. The liquid mixing device according to claim 3, wherein: Heating pipes are distributed on the bottom of the dissolving tank (7) and the inner wall of the liquid preparation tank (1), and the heating pipes are controlled by the electric box (9) for heating.

5. The liquid mixing device according to claim 3, wherein: A leak-proof structure is provided between the funnel (5) and the sterilization table (3), including a guide platform (302) provided on the sterilization table (3) corresponding to the position of the liquid distribution pipe (2); an active cavity (301) connected to the liquid distribution pipe (2) is passed through between the guide platform (302) and the sterilization table (3); a plug (501) is slidably provided at the bottom of the funnel (5); the plug (501) is connected to the funnel (5) through a spring (502), and the plug (501) matches the size of the active cavity (301); and an ejection mechanism is provided in the active cavity (301).

6. The liquid mixing device according to claim 5, characterized in that: The ejection mechanism includes a coupling sleeve (305) slidably arranged in the movable cavity (301), and slide grooves (303) extending from both sides of the movable cavity (301), wherein a transverse axis (304) is arranged in one of the slide grooves (303), and a gear (307) is sleeved on the transverse axis (304), and a sliding bar is arranged on the circumference of the coupling sleeve (305) and is clamped in the slide groove (303), wherein the sliding bar close to the gear (307) is arranged as a rack (306) meshing with the gear (307).

7. The liquid mixing device according to claim 5, wherein: Both ends of the guide platform (302) form inclined slopes.

8. The liquid mixing device according to claim 3, wherein: A rotating shaft (11) is rotatably arranged in the liquid dispensing tank (1), one end of the rotating shaft (11) is driven by a motor (10), and a stirring ring (12) is arranged on the rotating shaft (11).

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