Real-time dynamic blood separation system and method

Abstract

The embodiment of the invention provides a real-time dynamic blood separation system and method, and relates to the technical field of blood separation.According to the system, blood of a target patient is collected through a blood collection module, and the blood of the target patient is input into a target centrifugal cavity; target blood separation parameters are obtained on the basis of a centrifugal module, and blood in the target centrifugal cavity is centrifuged on the basis of the target blood separation parameters; meanwhile, the blood pressure of a target patient is monitored based on a blood pressure monitoring module, and when the blood pressure value fluctuation of the target patient is greater than a preset blood pressure value, the target blood separation parameters are calibrated and updated to obtain a new target blood separation parameter group; the centrifugal module continues to conduct centrifugation on the blood in the target centrifugal cavity according to the new target blood separation parameter set; and finally, the centrifuged blood components are output through the component output module. According to the blood collection device, blood can be efficiently separated while blood collection is conducted, and the efficiency of the whole blood separation process is improved.

Description

Technical Field

[0001] The present disclosure relates to the technical field of blood separation, and in particular to a real-time dynamic blood separation system and method. Background Art

[0002] As a key support for precision medicine, blood separation technology plays an important role in regenerative medicine, trauma treatment, and other fields. Currently, the most widely used clinical method is still blood collection and centrifugation, which is a cumbersome operation. The final centrifuged product preparation is unstable due to the time of blood collection. The amount of blood product cannot be adjusted in real time according to intraoperative needs, resulting in blood waste and product shortages, affecting treatment effectiveness.

[0003] To improve blood separation efficiency, some researchers have attempted to use continuous centrifugal blood separation systems, which simultaneously separate blood during blood collection. However, while existing continuous centrifugal blood separation systems achieve simultaneous blood collection and separation, they lack real-time monitoring capabilities and rely solely on fixed separation parameters for blood separation. This leads to numerous drawbacks in clinical applications, such as unstable separation results and low separation efficiency.

[0004] Therefore, how to improve the efficiency of the blood collection and separation process while ensuring the safety of the separation process has become an urgent problem to be solved. Summary of the Invention

[0005] In view of this, the embodiments of the present application provide a real-time dynamic blood separation system and method, which can efficiently perform blood separation while blood is being drawn.

[0006] In a first aspect, an embodiment of the present application provides a real-time dynamic blood separation system, comprising:

[0007] a blood collection module configured to collect blood from a target patient and transfer the blood from the target patient into a target centrifugal chamber; the target centrifugal chamber is detachable;

[0008] a centrifugal module configured to obtain target blood separation parameters and centrifuge the blood in the target centrifugal chamber based on the target blood separation parameters; the target centrifugal chamber is driven by a rotor to perform centrifugal motion to separate the blood;

[0009] a blood pressure monitoring module configured to monitor the blood pressure of the target patient and, when the blood pressure value of the target patient fluctuates by more than a preset blood pressure value, calibrate and update the target blood separation parameters to obtain a new target blood separation parameter set, so that the centrifugation module continues to centrifuge the blood in the target centrifugal chamber according to the new target blood separation parameter set;

[0010] The component output module is configured to output the blood components after centrifugation.

[0011] As an optional implementation of the embodiment of the present application, the centrifugal module is further configured as follows:

[0012] Acquiring a set of hematological parameters of the target patient;

[0013] The target blood separation parameter set is determined based on the set of hematology parameters and the target patient blood pressure.

[0014] As an optional implementation of the embodiment of the present application, the target centrifugal cavity adopts a spindle-shaped cavity, and the inner wall of the target centrifugal cavity is provided with a spiral guide groove; the depth of the guide groove decreases gradually from the proximal end to the distal end, and the cross-section of the groove body has a trapezoidal structure.

[0015] As an optional implementation of the embodiment of the present application, the blood collection module is connected to the target centrifugal cavity of the centrifugal module through an input rotary joint; the component output module is connected to the target centrifugal cavity of the centrifugal module through an output rotary joint;

[0016] The input rotary joint and the output rotary joint are made of polycarbonate material, and the structure adopts a self-locking snap-on design, with a double-lip silicone sealing ring and an anti-backflow valve embedded inside. As an optional embodiment of the present application, a temperature monitoring sensor is also provided in the centrifugal cavity, which is configured as follows:

[0017] monitoring the temperature in the centrifugal chamber;

[0018] When the temperature in the centrifugal chamber is greater than a preset temperature value, a refrigeration operation is started.

[0019] As an optional implementation of the embodiment of the present application, a speed monitoring sensor is further provided in the centrifugal cavity, which is configured as follows:

[0020] monitoring the rotational speed in the centrifugal chamber;

[0021] When the rotation speed in the centrifugal chamber exceeds a preset rotation speed range, a braking operation is initiated.

[0022] As an optional implementation of the embodiment of the present application, a pressure difference monitoring sensor is further provided in the centrifugal cavity and is configured as follows:

[0023] monitoring a pressure difference between an input rotary joint connection end and an output rotary joint connection end of the target centrifugal chamber;

[0024] When the pressure difference between the input rotary joint connection end and the output rotary joint connection end is greater than a preset pressure value, the pressure relief operation is started.

[0025] As an optional implementation of the present application, the optimal blood collection volume for individualization can be predicted by analyzing historical treatment data. The doctor can also decide the blood collection time based on the patient's specific intraoperative condition.

[0026] In a second aspect, the embodiments of the present application provide a real-time dynamic blood separation method, comprising:

[0027] Collecting blood from a target patient and injecting the blood into a target centrifugal chamber; the target centrifugal chamber is detachable;

[0028] acquiring target blood separation parameters, and centrifuging the blood in the target centrifugal chamber based on the target blood separation parameters;

[0029] monitoring the blood pressure of the target patient, and when the blood pressure fluctuation of the target patient is greater than a preset blood pressure value, calibrating and updating the target blood separation parameters to obtain a new target blood separation parameter set, so that the centrifugation module continues to centrifuge the blood in the target centrifugal chamber according to the new target blood separation parameter set;

[0030] Output the centrifuged blood components.

[0031] As an optional implementation of the embodiment of the present application, obtaining the target blood separation parameter includes:

[0032] Acquiring a set of hematological parameters of the target patient;

[0033] The target blood separation parameter set is determined based on the set of hematology parameters and the target patient blood pressure.

[0034] In a third aspect, an embodiment of the present application provides an electronic device comprising: a memory and a processor, wherein the memory is used to store a computer program; and the processor is used to enable the electronic device to implement the real-time dynamic blood separation method described in any one of the above embodiments when executing the computer program.

[0035] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, on which a computer program is stored. When the computer program is executed by a computing device, the computing device implements the real-time dynamic blood separation method described in any of the above embodiments.

[0036] The real-time dynamic blood separation system provided in an embodiment of the present application includes: a blood collection module, configured to collect blood from a target patient and input the blood of the target patient into a target centrifugal cavity; the target centrifugal cavity is detachable; a centrifugation module, configured to obtain target blood separation parameters and centrifuge the blood in the target centrifugal cavity based on the target blood separation parameters; a blood pressure monitoring module, configured to monitor the blood pressure of the target patient and, when the blood pressure value of the target patient fluctuates more than a preset blood pressure value, calibrate and update the target blood separation parameters to obtain a new target blood separation parameter group, so that the centrifugation module continues to centrifuge the blood in the target centrifugal cavity according to the new target blood separation parameter group; and a component output module, configured to output the centrifuged blood components.

[0037] This application monitors the patient's blood pressure in real time through a blood pressure monitoring module, accurately calibrates and updates the blood separation parameters when the blood pressure is abnormal, and allows the centrifugal module to continue to centrifuge efficiently based on the new parameters, so that the system can dynamically adapt to changes in the patient's physical condition and ensure that the blood separation process is stable and continuous. Centrifugal operations are performed based on real-time updated parameters to avoid the inability of fixed parameters to adapt to fluctuations in the patient's condition, reduce unstable separation effects, improve the accuracy and reliability of blood component separation, and contribute to subsequent medical applications. By dynamically adjusting parameters in real time, the blood separation process can be more closely aligned with the patient's actual physiological state, avoiding invalid or inefficient separation due to inappropriate parameters, and efficiently performing blood separation while drawing blood, thereby improving the efficiency of the overall blood separation process. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present application and, together with the description, serve to explain the principles of the present application.

[0039] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required in the embodiments or the description of the prior art. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0040] Figure 1 An overall diagram of the real-time dynamic blood separation system provided in an embodiment of the present application;

[0041] Figure 2 A flowchart of the steps of the real-time dynamic blood separation method provided in an embodiment of the present application;

[0042] Figure 3 A schematic diagram of the hardware structure of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0043] In order to more clearly understand the above-mentioned objectives, features and advantages of the present disclosure, the scheme of the present disclosure will be further described below. It should be noted that the embodiments of the present disclosure and the features therein can be combined with each other in the absence of conflict.

[0044] In the following description, many specific details are set forth to facilitate a full understanding of the present disclosure, but the present disclosure may also be implemented in other ways different from those described herein; it is obvious that the embodiments in the specification are only part of the embodiments of the present disclosure, rather than all of the embodiments.

[0045] In the embodiments of the present application, words such as "exemplary" or "for example" are used to indicate examples, illustrations, or descriptions. Any embodiment or design described as "exemplary" or "for example" in the embodiments of the present application should not be interpreted as being more preferred or advantageous than other embodiments or designs. Specifically, the use of words such as "exemplary" or "for example" is intended to present the relevant concepts in a concrete way. In addition, in the description of the embodiments of the present application, unless otherwise specified, the meaning of "multiple" refers to two or more.

[0046] It should be noted that, in this document, the term "comprises" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article, or apparatus comprising a series of elements includes not only those elements, but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus. In the absence of further limitations, an element defined by the phrase "comprises a ..." does not exclude the presence of other identical elements in the process, method, article, or apparatus comprising the element.

[0047] The present invention provides a real-time dynamic blood separation method. Figure 1 As shown, the real-time dynamic blood separation system includes:

[0048] The blood collection module 11 is configured to collect blood from a target patient and inject the blood from the target patient into a target centrifugal chamber.

[0049] Wherein, the target centrifugal chamber is detachable.

[0050] In some embodiments, the blood collection module 11 collects blood from the target patient's blood vessels through a medical needle and then transports the collected blood into the centrifugal chamber to provide raw materials for subsequent blood component separation.

[0051] It should be noted that, since the target centrifugal chamber is detachable, in the embodiment of the present application, a centrifugal chamber of appropriate volume size can be selected as the target centrifugal chamber according to the current clinical scenario requirements; therefore, it is necessary to determine the target centrifugal chamber volume based on the clinical scenario requirements and the patient's hematological parameters before collecting blood from the target patient, and then configure the centrifugal chamber of corresponding volume size as the target centrifugal chamber in the current blood separation system, so as to adapt to various centrifugal scenarios through centrifugal chambers of different volume sizes.

[0052] Furthermore, the volume of the centrifuge chamber can be determined based on the patient's blood pressure and the clinical demand for different blood components. For example, patients with relatively high blood pressure have a relatively fast blood flow rate, and the time it takes to process and exchange blood in the centrifuge chamber is short. In order to ensure the separation of red blood cells, it is usually necessary to select a centrifuge chamber with a larger volume for processing. For clinical scenarios requiring a single blood component, in order to improve the recovery rate of the component obtained after blood separation and avoid the mixing of red blood cells in the products collected later, the volume of the centrifuge chamber needs to be increased. In some special patients, whose blood viscosity is high, a larger volume chamber can also be used to extend the centrifugation time to ensure sufficient sedimentation of red blood cells.

[0053] In an embodiment of the present application, the blood collection module is connected to the target centrifugal cavity of the centrifugal module through an input rotary joint; the component output module is connected to the target centrifugal cavity of the centrifugal module through an output rotary joint.

[0054] The input rotary joint and the output rotary joint are made of polycarbonate material, and the structure adopts a self-locking snap-on design, with a double-lip silicone sealing ring and an anti-backflow valve embedded inside.

[0055] Specifically, the blood collection module is connected to the target centrifugal chamber of the centrifuge module via an input rotary joint and is responsible for continuously inputting the target patient's blood into the centrifugal chamber. The component output module is connected to the target centrifugal chamber of the centrifuge module via an output rotary joint and is responsible for outputting the separated plasma matrix from the target centrifugal chamber.

[0056] Furthermore, the main bodies of the input rotary joint and the output rotary joint are made of polycarbonate material. This is because polycarbonate has the characteristics of high strength, chemical corrosion resistance, and good transparency, and can withstand the mechanical stress generated by the high-speed rotation of the centrifugal cavity, while facilitating the observation of the internal fluid state.

[0057] It should be noted that the target centrifugal cavity is also provided with a card slot corresponding to the input rotary joint and the output rotary joint. The self-locking snap structure provided on the input rotary joint and the output rotary joint enables quick installation and disassembly with one hand. Specifically, the engagement depth of the self-locking snap structure can be 2.8mm, and it can withstand an axial tensile force of not less than 150N. The self-locking snap structure facilitates quick installation by medical staff, thereby shortening the operation time to cope with scenarios where rapid blood collection and blood separation are required during emergency or surgery. At the same time, the self-locking snap structure can better ensure the stability of the connection compared to manual screwing, and prevent the device from falling off during the centrifugation process.

[0058] Double-lip silicone sealing rings are embedded within the input and output rotary joints. These rings feature high elasticity, low friction, and anti-aging properties, allowing for direct blood contact. The inner sealing ring adheres closely to the rotating shaft, while the outer sealing ring isolates the external environment, creating a double barrier. During high-speed rotation, these rings elastically deform to fill the tiny gap between the joint and the cavity, preventing blood from leaking into the device or outside, ensuring a leakage rate that meets the safety and effectiveness requirements of the device. Furthermore, the low friction properties of silicone reduce mechanical wear on the rotary joints, extending their service life while also reducing the generation of particulate contaminants and enhancing biosafety.

[0059] At the same time, anti-backflow valves are also provided in the input rotary joint and the output rotary joint, which can prevent blood from flowing back into the blood collection tube during the blood collection and separation process, avoiding contamination of the patient's blood vessels or causing serious complications such as air embolism.

[0060] In an embodiment of the present application, the target centrifugal cavity adopts a spindle-shaped cavity, and a spiral guide groove is provided on the inner wall of the target centrifugal cavity; the depth of the guide groove decreases gradually from the proximal end to the distal end, and the cross-section of the groove body has a trapezoidal structure.

[0061] Specifically, the centrifugal chamber is spindle-shaped (similar to an olive) with narrow ends and a wide middle, and the long axis coincides with the centrifugal rotation axis. The expanded area in the middle provides a larger centrifugal space, prolonging the residence and exchange time of blood in the chamber, ensuring full separation of red blood cells and plasma matrix; the tapered structures at both ends guide the fluid in and out smoothly, reducing turbulent impact at the inlet and eddy current loss at the outlet, and improving separation efficiency. At the same time, by replacing chambers of different volume sizes, it can adapt to the needs of different patients' hematological parameters and product quantities.

[0062] The guide grooves extend in a spiral along the inner wall of the centrifugal chamber, spiraling from the proximal end (blood inlet) to the distal end (red blood cell enrichment end). The depth of the guide grooves at the proximal end (inlet) is relatively large (e.g., the initial depth), which facilitates rapid guidance of the rotation direction of whole blood in the initial stage of centrifugation; the depth at the distal end (outlet) gradually decreases (e.g., the final depth is less than the initial depth), saving space for the storage of settled red blood cells. The structure is trapezoidal (wide at the top and narrow at the bottom), with the upper base wider than the lower base, and the groove wall at a certain inclination angle to the axis of the chamber.

[0063] Furthermore, under the action of centrifugal force, blood initially slides along the walls of the guide channel toward the distal end, forming a directional migration path and accumulation space. The trapezoidal shape of the channel reduces vertical impact between the fluid and the channel wall, and combined with the spiral direction, it creates a stable laminar flow within the channel during the initial centrifugation, preventing platelet activation. The proximal end (high-depth area) accommodates more of the initial inflow of whole blood and guides its rotational direction. The distal end (low-depth area) reduces the channel depth, increasing the storage space for red blood cells and improving the extraction rate of plasma matrix.

[0064] The centrifugation module 12 is configured to obtain target blood separation parameters and centrifuge the blood in the target centrifugal chamber based on the target blood separation parameters.

[0065] Specifically, the target blood separation parameters may include centrifugal force, centrifugal acceleration, and centrifugation time. Based on these target blood separation parameters, the centrifuge chamber is driven to rotate, achieving real-time separation of red blood cells and plasma matrix. Red blood cells with higher specific gravity are preferentially concentrated toward the distal end. The separated plasma matrix is ​​then discharged through an output rotary joint, simultaneously completing blood collection and blood component separation.

[0066] Specifically, when the centrifugal chamber is driven to rotate by the target blood separation parameter, the rotor connected to the target centrifugal chamber drives the target centrifugal chamber to perform centrifugal motion under the corresponding centrifugal force, thereby achieving blood separation.

[0067] The blood pressure monitoring module 13 is configured to monitor the blood pressure of the target patient and, when the blood pressure value fluctuation of the target patient is greater than a preset blood pressure value, calibrate and update the target blood separation parameters to obtain a new target blood separation parameter group, so that the centrifugation module continues to centrifuge the blood in the target centrifugal chamber according to the new target blood separation parameter group.

[0068] It should be noted that during the blood collection and separation process, changes in blood pressure will significantly change the flow resistance of blood in the centrifugal chamber. For example, when blood pressure rises, the pressure of blood flowing into the centrifugal chamber increases, which may cause red blood cells to not fully settle and flow out with the plasma; when blood pressure drops, the blood flow rate slows down, which is not in line with the concept of gentle centrifugation and may cause platelet loss, affecting the output efficiency of the plasma matrix. Therefore, in order to eliminate the impact of the patient's own blood pressure changes on the blood separation efficiency, the embodiment of the present application monitors the blood pressure of the target patient in real time through the blood pressure monitoring module 13, and continuously obtains the blood pressure data of the target patient to identify abnormal fluctuations in the patient's blood pressure; and then when the blood pressure value fluctuates beyond the preset blood pressure value, it triggers the centrifugal force parameter update, thereby offsetting the interference of abnormal blood pressure fluctuations on the blood separation efficiency.

[0069] In some embodiments, the real-time blood pressure value (systolic pressure, diastolic pressure or mean arterial pressure) of the target patient can be obtained through a non-invasive blood pressure sensor (such as an oscillation cuff) or an invasive blood pressure monitoring interface configured in the real-time dynamic blood separation system to accurately capture blood pressure fluctuations during the centrifugation process, timely update the target blood separation parameters, and improve blood separation efficiency.

[0070] Specifically, the preset blood pressure value can be set according to the average blood pressure of the target patient before blood collection or after anesthesia is stabilized, and the average blood pressure is set as the baseline. When the measured blood pressure value deviates from the baseline by 10%, for example, the systolic blood pressure baseline is 120 mmHg, and the fluctuation is greater than 12 mmHg, the update of the target blood separation parameter is triggered, the parameter update process is started, and a new target blood separation parameter group is obtained, so that the centrifugal module continues to centrifuge the blood in the target centrifugal cavity according to the new target blood separation parameter group.

[0071] For example, patient A needs to undergo blood sampling and separation during surgery. If patient A's blood pressure drops due to bleeding, the blood pressure monitoring module 13 detects that the blood pressure has dropped by 18 mmHg, which is greater than 12 mmHg, that is, the dropped blood pressure value exceeds 10% of the baseline blood pressure value of 120 mmHg. In this case, the target blood separation parameters need to be calibrated and updated. Specifically, the centrifugal force in the target blood separation parameters can be reduced, thereby slowing down the speed of the rotor connected to the target centrifugal chamber and reducing the speed of the target centrifugal chamber to avoid the loss of platelets due to the slowdown in blood flow rate. At the same time, a gentle centrifugal method is used to avoid platelet activation.

[0072] The embodiment of the present application uses a blood pressure monitoring module to monitor the patient's blood pressure in real time during the blood collection process, and then promptly updates the target blood separation parameters, that is, adaptively adjusts parameters such as rotor speed, centrifugal force, centrifugation time, etc., to accurately control the centrifugal movement of the target centrifugal cavity.

[0073] The component output module 14 is configured to output the blood components after centrifugation.

[0074] In the embodiment of the present application, the output rotary joint of the component output module 14 is precisely docked with the proximal end of the centrifugal cavity (the plasma matrix enriched area), and utilizes the centrifugal force field distribution of the cavity (the plasma matrix density is low at the proximal end and the red blood cell density is high at the distal end), in conjunction with the stepped guide design of the output joint, to naturally form a "red blood cell countercurrent barrier" to prevent red blood cells from mixing into the plasma matrix flow channel; at the same time, due to the built-in spiral laminar flow guide of the output joint, the plasma matrix (containing platelets, growth factors, etc.) is converted into a stable laminar flow and discharged at a uniform speed, thereby reducing the shear activation of platelets by turbulence, reducing the generation rate of cell fragments, and ensuring the biological activity of the plasma matrix. Due to their high density, red blood cells continue to migrate toward the distal end in the centrifugal field and converge in the red blood cell sedimentation tank at the distal end of the cavity; the sedimentation tank can be connected to the red blood cell storage bag through an independent pipeline, and can also be linked to the saline washing unit when outputting, and the red blood cell surface is rinsed with 0.9% saline to remove residual plasma and platelets, ensure the purity of the red blood cells, and then simultaneously complete the collection of different blood components during the centrifugation process, realizing the integration of the entire process of "blood collection-separation-output".

[0075] This application monitors the patient's blood pressure in real time through a blood pressure monitoring module, accurately calibrates and updates the blood separation parameters when the blood pressure is abnormal, and allows the centrifugal module to continue to centrifuge efficiently based on the new parameters, so that the system can dynamically adapt to changes in the patient's physical condition and ensure that the blood separation process is stable and continuous. Centrifugal operations are performed based on real-time updated parameters to avoid the inability of fixed parameters to adapt to fluctuations in the patient's condition, reduce unstable separation effects, improve the accuracy and reliability of blood component separation, and contribute to subsequent medical applications. By dynamically adjusting parameters in real time, the blood separation process can be more closely aligned with the patient's actual physiological state, avoiding invalid or inefficient separation due to inappropriate parameters, and efficiently performing blood separation while drawing blood, thereby improving the efficiency of the overall blood separation process.

[0076] As an extension and refinement of the above embodiment, the centrifugal module 12 in the real-time dynamic blood separation system is further used to: obtain the hematological parameter set of the target patient, and determine the target blood separation parameter group based on the hematological parameter set and the blood pressure of the target patient.

[0077] Specifically, the hematological parameter set includes patient physiological data used to dynamically calculate target blood separation parameters. The hematological parameter set is collected from the patient before blood is drawn and separated, and specifically includes: hematocrit, blood viscosity, erythrocyte sedimentation rate, platelet count, and other hematological parameters. Target thresholds corresponding to current clinical needs (such as platelet enrichment rate and leukocyte residual rate quantification standards) are then combined to calculate blood viscosity. The blood viscosity and hematological parameters are then input into a target cell sedimentation dynamics model constructed based on the Navier-Stokes equation and cell motion equations (including Stokes' law, cell collision probability model, etc.). The spatial grid is divided by the finite element method and the cells are labeled by the Lagrangian particle method to simulate the motion trajectories of red blood cells, white blood cells, and platelets in the separation tube. Then, based on the motion trajectories, Monte Carlo simulation is used to predict the distribution of plasma matrix components corresponding to different centrifugal parameter combinations (centrifugal force, time, acceleration curve). Finally, candidate parameters that meet the clinical goals are screened from the simulation results. Then, a genetic algorithm is used to optimize the search to determine the target centrifugal parameter combination that meets the needs, and then the target blood separation parameter set is determined.

[0078] As an extension and refinement of the above embodiment, in an embodiment of the present application, a temperature monitoring sensor is further provided in the centrifugal cavity for monitoring the temperature in the centrifugal cavity. When the temperature in the centrifugal cavity is greater than a preset temperature value, a refrigeration operation is started.

[0079] Specifically, the temperature inside the centrifuge chamber is monitored in real time by a temperature sensor to avoid thermal damage to blood components caused by heat generation due to high-speed rotation or ambient temperature fluctuations.

[0080] Since the current recommended storage temperature for platelets is 20-24°C, the preset temperature value can be set to 24°C. When the temperature inside the centrifugal chamber is greater than 24°C, the chamber temperature is quickly lowered through a built-in micro-refrigeration module (such as a semiconductor refrigerator) or an external cooling pipeline to ensure that the activity of platelets is not destroyed by high temperature.

[0081] Furthermore, the temperature in the centrifugal chamber is monitored in real time by a temperature monitoring sensor, and the temperature is maintained below 24°C to ensure the stability of the blood separation environment and the safety of the separation process.

[0082] In an embodiment of the present application, a speed monitoring sensor is further provided in the centrifugal cavity for monitoring the speed in the centrifugal cavity; when the speed in the centrifugal cavity exceeds a preset speed range, a braking operation is initiated.

[0083] Specifically, the speed of the centrifuge chamber is monitored in real time through a speed monitoring sensor. When the speed of the centrifuge chamber exceeds the normal safety range, the braking operation is immediately initiated to control the centrifuge chamber to stop running, thereby preventing abnormal speed caused by drive module failure or incorrect parameter setting, which may cause red blood cell breakage or equipment damage.

[0084] Furthermore, the preset speed range can be determined based on the speed value corresponding to the centrifugal force in the separation parameter, and the upper and lower limits of the range can be a 10% fluctuation based on the speed value corresponding to the centrifugal force. For example, if the speed value corresponding to the centrifugal force is 5000 rpm, the preset speed range is 5500 rpm or 4500 rpm, and braking is triggered if the range is exceeded.

[0085] It should be noted that the starting braking operation can quickly offset the rotor kinetic energy through the electromagnetic force of the magnetic levitation bearing, and cooperate with the mechanical braking device to ensure that the rotation stops within 10 seconds.

[0086] This can avoid a surge in the red blood cell fragmentation rate due to excessively high rotation speed, and prevent mechanical failures (such as bearing wear and cavity deformation) caused by equipment overload, thereby reducing clinical operation risks.

[0087] In an embodiment of the present application, a pressure difference monitoring sensor is also provided in the centrifugal cavity, which is used to monitor the pressure difference between the input rotary joint connection end and the output rotary joint connection end of the target centrifugal cavity; when the pressure difference between the input rotary joint connection end and the output rotary joint connection end is greater than the preset pressure value, the pressure relief operation is started.

[0088] The pressure difference between the input rotary joint connection end and the output rotary joint connection end of the centrifugal chamber is monitored by the pressure differential monitoring sensor, so as to promptly detect abnormal conditions such as flow channel blockage, joint leakage or blood coagulation, and ensure the safety of the fluid pathway.

[0089] It should be noted that the preset threshold can be set according to actual conditions, for example, it can be set to 20kPa, that is, when the pressure difference is greater than 20kPa, the pressure relief operation is started. During the normal blood collection and separation process, the pressure difference is usually maintained at 5-10kPa. When red blood cells accumulate and the output pipeline is folded, the pressure difference may exceed 20kPa. Then, after determining that the pressure difference exceeds the standard, the pressure relief operation is immediately started. A pressure relief valve can be installed on the pipe between the centrifugal cavity and the output rotary joint, and then the pressure relief valve is automatically opened to start the pressure relief operation, releasing the centrifugal cavity pressure to a safe range to avoid joint collapse or blood spillage due to high pressure. The pressure relief valve can be connected to a waste liquid collection bag through a pipe to prevent environmental pollution or infection.

[0090] Furthermore, the embodiment of the present application monitors the blood collection and centrifugation process through multiple sensors to achieve multi-dimensional safety protection and ensure that the blood collection and centrifugation process is stable, efficient and controllable.

[0091] It should be noted that the real-time dynamic blood separation system provided in the embodiment of the present application can also display the equipment status and relevant data in the blood collection and separation process to medical staff through a visual interface, so that medical staff can view it in real time. At the same time, the data in the blood collection and separation process can be uploaded to the medical cloud platform in real time, supporting cross-institutional doctors to review it, which is convenient for reference by personnel across the platform.

[0092] Furthermore, a blood collection volume prediction model can be trained based on a large amount of historical treatment data of patients stored in the platform (such as surgery type, bleeding volume, blood collection volume) and their corresponding physiological indicators (weight, blood volume). Through the trained predictive blood collection volume model, the optimal blood collection volume can be efficiently obtained based on the current patient's physiological indicators and clinical surgery information, which makes it easier to determine the volume of the centrifugal chamber and the blood collection time. At the same time, medical staff can also manually adjust the blood collection time according to the actual intraoperative conditions (such as bleeding rate and wound surface requirements) to achieve accurate decision-making, thereby avoiding blood waste and reducing the risk of excessive blood collection.

[0093] Based on the same inventive concept, as an implementation of the above-mentioned system, an embodiment of the present application also provides a real-time dynamic blood separation method. This embodiment corresponds to the aforementioned system embodiment. For ease of reading, this embodiment will no longer repeat the details of the aforementioned system embodiment one by one, but it should be clear that a real-time dynamic blood separation method in this embodiment can correspond to the implementation of all the contents in the aforementioned system embodiment.

[0094] The present invention provides a real-time dynamic blood separation method. Figure 2 Schematic diagram of the process of the real-time dynamic blood separation method, as shown in Figure 2 As shown, the real-time dynamic blood separation method includes the following steps:

[0095] S201, collecting blood from a target patient and injecting the blood into a target centrifugal chamber; the target centrifugal chamber is detachable;

[0096] S202, obtaining target blood separation parameters, and centrifuging the blood in the target centrifugal chamber based on the target blood separation parameters;

[0097] S203, monitoring the blood pressure of the target patient, and when the blood pressure fluctuation of the target patient is greater than a preset blood pressure value, calibrating and updating the target blood separation parameters to obtain a new target blood separation parameter set, and continuing to centrifuge the blood in the target centrifugal chamber according to the new target blood separation parameter set;

[0098] S204: Output the centrifuged blood components.

[0099] As an optional implementation of the embodiment of the present application, the step of obtaining the target blood separation parameter includes the following steps:

[0100] Acquiring a set of hematological parameters of the target patient;

[0101] The target blood separation parameter set is determined based on the set of hematology parameters and the target patient blood pressure.

[0102] Based on the same inventive concept, an embodiment of the present disclosure further provides an electronic device. Figure 3 A schematic diagram of the structure of an electronic device provided in an embodiment of the present disclosure, such as Figure 3 As shown, the electronic device provided in this embodiment includes: a memory 301 and a processor 302, wherein the memory 301 is used to store a computer program; and the processor 302 is used to execute the real-time dynamic blood separation method provided in the above embodiment when executing the computer program.

[0103] Based on the same inventive concept, an embodiment of the present application also provides a computer-readable storage medium, which stores a computer program. When the computer program is executed by a processor, the computing device implements the real-time dynamic blood separation method provided in the above embodiment.

[0104] Those skilled in the art will appreciate that the embodiments of the present application may be provided as systems, methods, or computer program products. Therefore, the present application may take the form of a complete hardware embodiment, a complete software embodiment, or an embodiment combining software and hardware. Furthermore, the present application may take the form of a computer program product implemented on one or more computer-usable storage media containing computer-usable program code.

[0105] The processor may be a central processing unit, or other general-purpose processors, digital signal processors, application-specific integrated circuits, off-the-shelf programmable gate arrays or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or any conventional processor, etc.

[0106] The memory may include non-persistent memory, random access memory and / or non-volatile memory in a computer-readable medium, such as read-only memory or flash memory. Memory is an example of a computer-readable medium.

[0107] Computer-readable media includes both permanent and non-permanent, removable and non-removable storage media. Storage media can implement any method or technology for storing information, which can be computer-readable instructions, data structures, program modules, or other data. Examples of computer storage media include, but are not limited to, phase-change memory, static random access memory, dynamic random access memory, other types of random access memory, read-only memory, electrically erasable programmable read-only memory, flash memory or other memory technology, compact disc read-only memory, digital versatile disc or other optical storage, magnetic cassettes, magnetic disk storage or other magnetic storage devices, or any other non-transmission medium that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include temporary computer-readable media, such as modulated data signals and carrier waves.

[0108] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A real-time dynamic blood separation system, characterized in that: include: a blood collection module configured to collect blood from a target patient and inject the blood from the target patient into a target centrifugal chamber; The target centrifugal chamber is detachable; a centrifugation module configured to obtain target blood separation parameters and centrifuge the blood in the target centrifugal chamber based on the target blood separation parameters; a blood pressure monitoring module configured to monitor the blood pressure of the target patient and, when the blood pressure value of the target patient fluctuates by more than a preset blood pressure value, calibrate and update the target blood separation parameters to obtain a new target blood separation parameter set, so that the centrifugation module continues to centrifuge the blood in the target centrifugal chamber according to the new target blood separation parameter set; The component output module is configured to output the blood components after centrifugation.

2. The system according to claim 1, wherein: The centrifugal module is further configured to: Acquiring a set of hematological parameters of the target patient; The target blood separation parameter set is determined based on the set of hematology parameters and the target patient blood pressure.

3. The system according to claim 1, characterized in that The target centrifugal cavity adopts a spindle-shaped cavity, and the inner wall of the target centrifugal cavity is provided with a spiral guide groove; the depth of the guide groove decreases gradually from the proximal end to the distal end, and the cross section of the groove body has a trapezoidal structure.

4. The system according to claim 1, wherein: The blood collection module is connected to the target centrifugal cavity of the centrifugal module through an input rotary joint; the component output module is connected to the target centrifugal cavity of the centrifugal module through an output rotary joint; The input rotary joint and the output rotary joint are made of polycarbonate material, and the structure adopts a self-locking snap-on design, with a double-lip silicone sealing ring and an anti-backflow valve embedded inside.

5. The system according to claim 1, wherein: The centrifugal chamber is also provided with a temperature monitoring sensor, which is configured to: monitoring the temperature in the centrifugal chamber; When the temperature in the centrifugal chamber is greater than a preset temperature value, a refrigeration operation is started.

6. The system according to claim 1, wherein: The centrifugal chamber is also provided with a rotation speed monitoring sensor, which is configured to: monitoring the rotational speed in the centrifugal chamber; When the rotation speed in the centrifugal chamber exceeds a preset rotation speed range, a braking operation is initiated.

7. The system according to claim 1, wherein: The centrifugal chamber is also provided with a pressure difference monitoring sensor, which is configured to: monitoring a pressure difference between an input rotary joint connection end and an output rotary joint connection end of the target centrifugal chamber; When the pressure difference between the input rotary joint connection end and the output rotary joint connection end is greater than a preset pressure value, the pressure relief operation is started.

8. A real-time dynamic blood separation method, characterized in that: include: collecting blood from a target patient and transfusing the blood from the target patient into a target centrifugal chamber; The target centrifugal chamber is detachable; acquiring target blood separation parameters, and centrifuging the blood in the target centrifugal chamber based on the target blood separation parameters; monitoring the blood pressure of the target patient, and when the blood pressure fluctuation of the target patient is greater than a preset blood pressure value, calibrating and updating the target blood separation parameters to obtain a new target blood separation parameter set, so as to continue centrifuging the blood in the target centrifugal chamber according to the new target blood separation parameter set; Output the centrifuged blood components.

9. The method according to claim 8, characterized in that The step of obtaining target blood separation parameters includes: Acquiring a set of hematological parameters of the target patient; The target blood separation parameter set is determined based on the set of hematology parameters and the target patient blood pressure.

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