High-weather-resistance silicone hydrogel contact lens material and preparation method thereof

Abstract

The invention relates to the technical field of preparation of contact lens materials, in particular to a high-weather-resistance silicone hydrogel contact lens material and a preparation method thereof. The preparation method of the contact lens material comprises the following steps: S1, adding a polymeric monomer, a weather-proof additive and a functional additive into absolute ethyl alcohol, and stirring in a dark place to obtain a premixed solution; and S2, adding nano silver and nano titanium dioxide into the premixed solution, performing ultrasonic dispersion, adding a cross-linking agent and an initiator, performing uniform mixing, injecting the mixture into a contact lens mold, performing photo-initiation polymerization reaction under the protection of inert gas, and performing washing with deionized water and equilibrium with a boric acid buffer solution to obtain the high-weather-resistance silicon hydrogel contact lens material. The prepared contact lens material not only has high oxygen permeability and high light transmittance, but also can effectively ensure that the cornea obtains sufficient oxygen, and is also excellent in weather resistance and not easy to deform or damage.

Description

Technical Field

[0001] The present invention relates to the technical field of contact lens material preparation, and in particular to a highly weather-resistant silicone hydrogel contact lens material and a preparation method thereof. Background Art

[0002] Contact lenses are important medical devices for vision correction and beauty. Silicone hydrogel has become the mainstream material for modern contact lenses due to its ultra-high oxygen permeability. The core advantage of this material comes from the siloxane segments introduced into its molecular structure, which can directly transport oxygen through the dissolution-diffusion mechanism, significantly reducing the risk of complications such as edema and neovascularization caused by corneal hypoxia.

[0003] However, although the silicone component in traditional silicone hydrogel materials can greatly improve oxygen permeability, its hydrophobicity will reduce the hydrophilicity of the material, resulting in insufficient wettability of the lens surface, which can easily cause dry eye discomfort. To balance this contradiction, conventional solutions require the introduction of a high proportion of hydrophilic monomers, but this will lead to a decrease in cross-linking density and a loose network structure, and rapid evaporation of water will cause the gel to shrink and deform. Secondly, lipids and proteins in tears are easily adsorbed to the lens surface to form a biofilm. Traditional silicone hydrogels are enriched in silicone microregions on the surface, and precipitates are easily deposited, which not only causes blurred vision and irritation, but also becomes a breeding ground for microorganisms, increasing the risk of keratitis. In addition, ultraviolet radiation and thermal oxidation are key environmental factors that cause material aging. Ultraviolet rays can cause the breakage of the silicone main chain and the degradation of aromatic ultraviolet absorbers, causing the lens transmittance to decrease and turn yellow. Thermal oxidation reactions cause the cross-linked network to break, which manifests as permanent hardening of the material and decreased oxygen permeability. Traditional silicone hydrogel materials have significant limitations in long-term stability, anti-deposition and mechanical durability. Based on the above defects, the present application provides a highly weather-resistant silicone hydrogel contact lens material and a preparation method thereof, which are used to prepare silicone hydrogel contact lenses with high oxygen permeability, comfortable wearing feel and weather resistance. Summary of the Invention

[0004] In order to solve the technical problems mentioned in the background technology, the present application provides a highly weather-resistant silicone hydrogel contact lens material and a preparation method thereof.

[0005] A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1: adding the polymerization monomer, weather-resistant additive, and functional additive to anhydrous ethanol, stirring for 1-2 hours in the dark, and obtaining a premixed solution after stirring evenly; Step S2: adding nanosilver and nanotitanium dioxide to the premixed solution, dispersing them ultrasonically, adding a crosslinking agent and an initiator, mixing them evenly, and injecting them into a contact lens mold. Under the protection of an inert gas, a photoinitiated polymerization reaction is carried out, and the material is washed with deionized water and balanced with a boric acid buffer solution to obtain a highly weather-resistant silicone hydrogel contact lens material.

[0006] Preferably, in step S1, the mass ratio of the polymerization monomer, the weather-resistant additive, the functional additive and the anhydrous ethanol is 60-85:1-5:8-15:200-250.

[0007] Preferably, in step S1, the mass ratio of the polymerization monomer, the weather-resistant additive, the functional additive and the anhydrous ethanol is 60-85:1-5:8-15:200-250.

[0008] Preferably, the polymerization monomers in step S1 are composed of silicon-based monomers, N-vinyl pyrrolidone and hydroxyethyl methacrylate in a mass ratio of 15-30:10-15:20-30.

[0009] Preferably, the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropenyloxysilane and polydimethylsiloxane monomethacrylate in a mass ratio of 60-75:20-30:25-32.

[0010] Preferably, the weather-resistant additive in step S1 is one or more of 2-hydroxy-4-methoxybenzophenone, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, and tris(2-hydroxy-4-octyloxyphenyl)triazine.

[0011] Preferably, the functional additive in step S1 is one or more of hexafluorobutyl methacrylate, sulfobetaine methacrylate, and poly (N-isopropylacrylamide).

[0012] Preferably, in step S2, the mass ratio of the premixed solution, nano-silver and nano-titanium dioxide is 100-120:0.3-0.5:1-3.

[0013] Preferably, the crosslinking agent in step S2 is composed of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20-25:1-2.

[0014] Preferably, the amount of the cross-linking agent added in step S2 is 0.1-1 wt % of the premixed solution.

[0015] Preferably, the initiator in step S2 is 2,2-dimethoxy-2-phenylacetophenone and / or phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide.

[0016] Preferably, the amount of the initiator added in step S2 is 0.1-0.5 wt % of the premixed solution.

[0017] Preferably, the conditions for the photopolymerization reaction in step S2 are: a wavelength of 365 nm and a light intensity of 10-15 mW / cm2 The ultraviolet light initiates the polymerization reaction for 30-40 minutes.

[0018] A highly weather-resistant silicone hydrogel contact lens material is prepared by the above method.

[0019] In summary, this application has the following beneficial effects: This application uses three polysilicone monomers: 3-[tri(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropenyloxysilane and polydimethylsiloxane monomethacrylate. The 3-[tri(trimethylsiloxy)silyl]propyl vinyl carbamate molecule contains three trimethylsiloxy groups. The siloxy chain segment provides a continuous oxygen transmission channel, thereby improving the oxygen permeability coefficient of the material. The carbamate group enhances the compatibility of siloxane with other monomers and reduces phase separation. Vinyl triisopropenyloxysilane acts as a cross-linking enhancer. The three isopropoxy groups form silanol groups after hydrolysis, which can react with other silicon-based monomers or nanoparticles to form a three-dimensional cross-linked structure, thereby improving the mechanical properties of the material. In addition, the siloxy cross-linked network after the hydrolysis of the isopropoxy groups is highly hydrophobic, which reduces the swelling rate of the lens in water and maintains dimensional stability. The three polysilicone monomers of polydimethylsiloxane monomethacrylate serve as flexible segments. The long-chain polydimethylsiloxane gives the material flexibility, reduces rigidity, and improves wearing comfort. In addition, the polydimethylsiloxane chain segments tend to migrate to the surface of the material, forming a low surface energy siloxane layer, reducing protein adsorption and deposition, and improving anti-fouling performance.

[0020] This application compounds silicon-based monomers and hydrophilic monomers. N-vinyl pyrrolidone has strong polarity and can absorb a large amount of water, thereby improving the moistness and oxygen permeability of the lens. Hydroxyethyl methacrylate can provide moderate rigidity and toughness, and synergistically improves the mechanical properties of the material with the silicon-based monomer. The three siloxane structures are complementary to form an efficient oxygen channel. 2-Hydroxy-4-methoxybenzophenone and silicon-oxygen bonds synergistically resist ultraviolet aging. Nano-TiO2 further enhances photostability and anti-degradation ability. Hexafluorobutyl methacrylate introduces fluorine to reduce surface energy and reduce protein and lipid deposition. DETAILED DESCRIPTION

[0021] The present application is further described in detail below with reference to the embodiments.

[0022] N-vinyl pyrrolidone used in the examples and comparative examples of the present application was purchased from Shanghai Hongjun New Materials Technology Co., Ltd.; hydroxyethyl methacrylate was purchased from Shandong Kejian Chemical Co., Ltd.; 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate was purchased from Wuhan Kangqiong Biotechnology Co., Ltd., and vinyl triisopropyloxysilane was purchased from Wuhan Kemik Biotechnology Co., Ltd.; polydimethylsiloxane monomethacrylate was purchased from Shanghai Yongzheng Chemical Co., Ltd.

[0023] Examples 1-3 provide a highly weather-resistant silicone hydrogel contact lens material and a preparation method thereof.

[0024] Example 1 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 15:10:20, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 60:20:25; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20:1, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0025] Example 2 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring in the dark for 1.5 hours at a stirring speed of 150 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 75:3:12:230, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 25:12:25, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 68:25:28; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 25 min at an ultrasonic power of 120 W and an ultrasonic frequency of 560 kHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into a contact lens mold. 2 The reaction mixture was exposed to ultraviolet light, photo-initiated polymerization for 35 minutes, washed twice with deionized water, and equilibrated with boric acid buffer for 18 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 110:0.4:2, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 22:1.5, and the addition amount of the cross-linking agent was 0.5wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the addition amount of the initiator was 0.3wt% of the premixed solution.

[0026] Example 3 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 2 hours in the dark at a stirring speed of 200 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 85:5:15:250, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 30:15:30, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 75:30:32; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 30 min at an ultrasonic power of 150 W and an ultrasonic frequency of 60 kHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into a contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 40 minutes, washed with deionized water three times, and balanced with boric acid buffer for 24 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 120:0.5:3, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 25:2, and the addition amount of the cross-linking agent was 1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the addition amount of the initiator was 0.5wt% of the premixed solution.

[0027] Comparative Example 1 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer and hydroxyethyl methacrylate in a mass ratio of 15:20, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 60:20:25; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20:1, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0028] Comparative Example 2 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer and N-vinyl pyrrolidone in a mass ratio of 15:10, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 60:20:25; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20:1, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0029] Comparative Example 3 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 15:10:20, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate and polydimethylsiloxane monomethacrylate in a mass ratio of 60:25; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20:1, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0030] Comparative Example 4 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 15:10:20, and the silicon-based monomer is composed of 3-[tris(trimethylsilyloxy)silyl]propyl vinyl carbamate and vinyl triisopropyleneoxysilane in a mass ratio of 60:20; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The material was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent consisted of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20:1, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0031] Comparative Example 5 A method for preparing a highly weather-resistant silicone hydrogel contact lens material comprises the following steps: Step S1, adding a polymerization monomer, 2-hydroxy-4-methoxybenzophenone, and hexafluorobutyl methacrylate to anhydrous ethanol, stirring for 1 hour in the dark at a stirring speed of 100 rpm, and after stirring evenly, obtaining a premixed solution, wherein the mass ratio of the polymerization monomer, 2-hydroxy-4-methoxybenzophenone, hexafluorobutyl methacrylate, and anhydrous ethanol is 60:1:8:200, the polymerization monomer is composed of a silicon-based monomer, N-vinyl pyrrolidone, and hydroxyethyl methacrylate in a mass ratio of 15:10:20, and the silicon-based monomer is composed of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane, and polydimethylsiloxane monomethacrylate in a mass ratio of 60:20:25; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse it by ultrasound for 20 minutes at an ultrasonic power of 100W and an ultrasonic frequency of 40KHz, add a crosslinking agent and an initiator, mix them evenly, and inject them into the contact lens mold. 2 The reaction mixture was exposed to ultraviolet light, photo-initiated polymerization for 30 minutes, washed once with deionized water, and equilibrated with boric acid buffer for 12 hours to obtain a highly weather-resistant silicone hydrogel contact lens material, wherein the mass ratio of the premixed solution, nano-silver, and nano-titanium dioxide was 100:0.3:1, the cross-linking agent was ethylene glycol dimethacrylate, and the amount of the cross-linking agent added was 0.1wt% of the premixed solution; the initiator was 2,2-dimethoxy-2-phenylacetophenone, and the amount of the initiator added was 0.1wt% of the premixed solution.

[0032] Performance testing The performance parameters of the highly weather-resistant silicone hydrogel contact lens materials prepared in Examples 1-3 and Comparative Examples 1-5 of the present application are as follows: Oxygen permeability coefficient: 201T oxygen permeability meter (Creathch / Rehder-Dev Co, USA) was used to test the polarographic method in accordance with the national standard GBT 11417.7-2012. k The unit is 10 -11 cm 2 / s·Pa; Visible light transmittance: tested in accordance with the national standard GB / T 11417.5-2012 “Ophthalmic optics contact lenses - Part 5: Test methods for optical properties”; Mechanical properties: tested using Instron mechanical testing machine; Aging resistance: Accelerated aging for 48 hours at 70°C and 75% relative humidity, tested using an Instron mechanical testing machine. The test results are shown in Table 1.

[0033] Table 1 Comprehensive properties of contact lens materials prepared in Examples 1-3 and Comparative Examples 1-5

[0034] As can be seen from Table 1, the contact lens material prepared in the present application not only has high oxygen permeability and light transmittance, which can effectively ensure that the cornea obtains sufficient oxygen and maintains corneal health, but also does not produce a foreign body sensation even when worn for a long time. It also has excellent weather resistance, is not easy to deform or damage, extends the service life, reduces the frequency of replacement, and brings economical and convenient experience to consumers.

[0035] The above embodiments are only preferred embodiments of the present invention and are not intended to limit the present invention in any form or substance. It should be noted that ordinary technicians in this technical field can make several improvements and supplements without departing from the present invention, and these improvements and supplements should also be regarded as protection for the present invention.

Claims

1. A method for preparing a highly weather-resistant silicone hydrogel contact lens material, characterized in that: The method comprises the following preparation steps: Step S1: adding polymerization monomers, weather-resistant additives, and functional additives to anhydrous ethanol, stirring for 1-2 hours in the dark, and obtaining a premixed solution after stirring evenly; Step S2: Add nanosilver and nanotitanium dioxide to the premixed solution, disperse them ultrasonically, add a crosslinker and an initiator, mix them evenly, inject them into a contact lens mold, perform a photoinitiated polymerization reaction under the protection of an inert gas, wash with deionized water, and balance with a boric acid buffer to obtain a highly weather-resistant silicone hydrogel contact lens material.

2. The method for preparing a highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: In the step S1, the mass ratio of the polymerization monomer, the weather-resistant additive, the functional additive and the anhydrous ethanol is 60-85:1-5:8-15:200-250.

3. The method for preparing the highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: The polymerization monomers in step S1 are composed of silicon-based monomers, N-vinyl pyrrolidone and hydroxyethyl methacrylate in a mass ratio of 15-30:10-15:20-30.

4. The method for preparing a highly weather-resistant silicone hydrogel contact lens material according to claim 3, wherein: The silicon-based monomer consists of 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate, vinyl triisopropyleneoxysilane and polydimethylsiloxane monomethacrylate in a mass ratio of 60-75:20-30:25-32.

5. The method for preparing the highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: The weather-resistant additive in step S1 is one or more of 2-hydroxy-4-methoxybenzophenone, 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, and tris(2-hydroxy-4-octyloxyphenyl)triazine.

6. The method for preparing the highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: The functional additive in step S1 is one or more of hexafluorobutyl methacrylate, sulfobetaine methacrylate, and poly (N-isopropylacrylamide).

7. The method for preparing the highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: In step S2, the mass ratio of the premixed solution, nano-silver and nano-titanium dioxide is 100-120:0.3-0.5:1-3.

8. The method for preparing the highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: In step S2, the crosslinking agent is composed of ethylene glycol dimethacrylate and pentaerythritol triacrylate in a mass ratio of 20-25:1-2; and the initiator is 2,2-dimethoxy-2-phenylacetophenone and / or phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide.

9. The method for preparing a highly weather-resistant silicone hydrogel contact lens material according to claim 1, wherein: The conditions for the photopolymerization reaction in step S2 are: a wavelength of 365 nm, a light intensity of 10-15 mW / cm 2 The ultraviolet light initiates the polymerization reaction for 30-40 minutes.

10. A highly weather-resistant silicone hydrogel contact lens material prepared by the preparation method according to any one of claims 1 to 9.

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