Traditional Chinese medicine composition for treating hypertension as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating hypertension and a preparation method and application thereof, and the traditional Chinese medicine composition comprises radix rehmanniae, radix cyathulae, radix salviae miltiorrhizae, ligusticum wallichii, eucommia ulmoides, radix puerariae, caulis spatholobi, gastrodia elata, uncaria rhynchophylla, concha haliotidis, selfheal, angelica sinensis, radix paeoniae rubra, fructus gardeniae, scutellaria baicalensis, peach kernels and safflower carthamus. The radix cyathulae is used for guiding downward flow of blood and tonifying liver and kidney, the radix salviae miltiorrhizae is used for promoting blood circulation to remove blood stasis, the rhizoma chuanxiong is used for promoting blood circulation to promote qi, dispelling wind and relieving pain, the cortex eucommiae is used for tonifying liver and kidney and strengthening muscles and bones, the radix puerariae is used for relieving muscles and dispelling wind and clearing and activating the channels and collaterals, the caulis spatholobi is used for promoting blood circulation to remove meridian obstruction and enriching blood, the rhizoma gastrodiae is used for stabilizing liver yang, calming endogenous wind and relieving spasm, and the uncaria is used for stabilizing liver yang, reducing blood pressure and regulating and controlling heart rate; the common peony root has the effects of clearing heat and cooling blood, the cape jasmine has the effects of clearing heat and cooling blood, the baical skullcap root has the effects of clearing heat and drying dampness, and the peach kernel and the safflower have the effects of promoting blood circulation and removing blood stasis, and all the medicines supplement one another to jointly play the roles of reducing blood pressure, improving circulation and protecting organs such as heart, brain and kidney.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating hypertension, a preparation method thereof and an application thereof. Background Art

[0002] Hypertension, one of the most common chronic diseases worldwide, is a key risk factor for cardiovascular and cerebrovascular diseases and is closely linked to their morbidity and mortality. With the accelerating aging of the global population, the prevalence of hypertension has shown an increasing trend year by year, becoming a major public health issue that seriously threatens human health and life safety. According to the World Health Organization, the number of hypertensive patients worldwide is enormous, and complications caused by hypertension, such as coronary heart disease and stroke, have led to significant disability and death in many patients, placing a heavy burden on families and society.

[0003] The situation is equally dire for elderly patients with hypertension. Elderly hypertension has unique clinical characteristics, often characterized by high systolic blood pressure but low or even low diastolic blood pressure. Studies have shown that two-thirds of hypertensive patients over the age of 60 have isolated systolic hypertension. Pulse pressure, the difference between systolic and diastolic blood pressure, normally ranges from 30 to 40 mmHg. An increase in pulse pressure is a key indicator of arteriosclerosis. Hypertension prevention and treatment guidelines clearly state that increased pulse pressure is a clinical hallmark of elderly hypertension and is positively correlated with overall mortality and cardiovascular events.

[0004] Currently, clinical guidelines recommend five major categories of antihypertensive drugs for the treatment of hypertension: calcium antagonists, diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, and angiotensin II receptor blockers. These drugs have demonstrated efficacy in lowering blood pressure and are widely used in clinical practice. However, their use has significant limitations in elderly patients with isolated systolic hypertension, who experience elevated systolic blood pressure but moderate or even low diastolic blood pressure. While lowering systolic blood pressure, diastolic blood pressure also decreases. This can lead to diastolic blood pressure falling below the normal lower limit of 60 mmHg before systolic blood pressure reaches the target level of 150 mmHg, potentially increasing the risk of ischemic events in vital organs such as the heart and brain.

[0005] While Western medicine offers the advantages of rapid effectiveness and strong blood pressure-lowering effects in treating hypertension, it also presents numerous challenges. For one thing, Western medicine has side effects. Calcium antagonists may cause headaches, flushing, lower limb edema, and other adverse reactions; diuretics may cause electrolyte imbalances and elevated blood sugar; beta-blockers may cause bradycardia and fatigue; angiotensin-converting enzyme inhibitors may cause side effects such as a dry cough; and angiotensin II receptor blockers, while having relatively few side effects, may also cause dizziness, fatigue, and other discomfort. Furthermore, Western medicine can cause significant blood pressure fluctuations during the blood pressure-lowering process, hindering stable blood pressure control. Furthermore, blood pressure rebound can occur after discontinuation, complicating treatment and increasing patient suffering.

[0006] Relatively speaking, while Traditional Chinese Medicine (TCM) isn't as effective and potent as Western medicine for lowering blood pressure, it's safe and stable. TCM uses syndrome differentiation and symptomatic treatment, prescribing medication based primarily on the patient's current symptoms, rather than solely relying on blood pressure. Regarding the paradox of high systolic and low diastolic blood pressure in the elderly, TCM believes this simply indicates an imbalance in the patient's yin and yang, preventing them from effectively regulating the yin and yang of their internal organs. TCM emphasizes a holistic approach, viewing the human body as a whole with the capacity for self-adjustment. TCM diagnosis and treatment utilizes medication to assist in overall body conditioning, correcting imbalances in the yin and yang of the internal organs, and removing predisposing factors such as phlegm and blood stasis, thereby restoring or approaching a balance between yin and yang. However, there is currently no widely recognized, targeted, and effective TCM herbal combination for the treatment of isolated systolic hypertension in the elderly. Summary of the Invention

[0007] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating hypertension, its preparation method and application. The various drugs in the composition complement each other and work together to lower blood pressure, improve circulation, and protect important organs such as the heart, brain, and kidneys.

[0008] The object of the present invention is achieved through the following technical solutions: The invention provides a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition comprises the following components: raw rehmannia root, cyathula root, salvia miltiorrhiza root, ligusticum chuanxiong root, eucommia bark, kudzu root, millettia reticulata, gastrodia elata, uncaria rhynchophylla, cassia bark, selfheal, angelica root, red peony root, gardenia jasminoides, scutellaria baicalensis, peach kernel and safflower.

[0009] The effects of each raw material in the composition are as follows: Rehmannia: It is a product that clears heat, nourishes yin and promotes body fluid. The acidic part of Rehmannia water extract has a antihypertensive effect. Intraperitoneal injection of Rehmannia water extract into rats has a significant antihypertensive effect on acute experimental hypertension.

[0010] Sichuan Achyranthes: It has the effect of directing blood downward, entering the liver and kidney meridians, nourishing the liver and kidney yin and suppressing yang. A decoction of Achyranthes significantly increased blood flow in the lower limbs of rats, dilating blood vessels. Both the decoction and alcohol extract of Achyranthes bidentata increased the number of open capillaries, counteracting adrenaline-induced arteriolar constriction. Oleanolic acid in Achyranthes bidentata exerts a blood pressure-lowering effect by affecting the L-arginine-nitric oxide pathway in the vascular endothelium. Furthermore, magnesium ions, which are closely linked to cardiovascular health, enhance fibrinolysis, anticoagulation, and coronary artery dilation.

[0011] Danshen (Salvia miltiorrhiza): Bitter in flavor and cold in nature, it enters the heart and liver meridians and is a key herb for promoting blood circulation and removing blood stasis. Tanshinone IIA, the main active ingredient in Danshen, promotes the regression of myocardial hypertrophy and fibrosis in hypertensive rats by regulating the expression of the renin-angiotensin system in myocardial tissue. It also promotes the expression of the anti-apoptotic protein B-lymphocytoma-2 (Bcl-2) while downregulating the pro-apoptotic protein Bcl-2-associated ventricular hypertrophy.

[0012] Chuanxiong: It promotes blood circulation and qi, dispels wind and relieves pain. It is considered a "blood qi medicine," boasting the ability to promote the flow of qi and blood, ascend to the head, dispel wind and relieve pain, making it a key remedy for headaches. The main active ingredient in Chuanxiong that lowers blood pressure is myricetin, which significantly increases phosphorylated AKT levels and decreases p38 mitogen-activated protein kinase (p38MAPK) phosphorylation and nuclear factor-κB / p65 levels.

[0013] Eucommia ulmoides: It has the effect of nourishing the liver and kidneys, strengthening the bones and muscles. The phenylpropanoid components and flavonoid components in Eucommia ulmoides have the effect of lowering blood pressure, promoting the proliferation of smooth muscle cells in patients, and producing a strong dilation effect on blood vessels. The relevant pharmacological mechanisms of Eucommia ulmoides against hypertension include inhibiting cAMP activity and Ca 2＋ Influx, regulates NO and the renin-angiotensin system, dilates blood vessels and increases coronary blood flow.

[0014] Pueraria root: It can relieve muscle tension, dispel wind, open up the meridians, elevate yang and relax tendons. It can guide qi, blood and body fluids upward, relieving and nourishing tendons. The main active ingredients in Pueraria root that lower blood pressure are β-sitosterol and formononetin. β-sitosterol can lower blood lipids, while formononetin indirectly lowers blood pressure by downregulating the mRNA levels of p47phox and NOX4.

[0015] Millettia repens: It has the effects of promoting blood circulation, tonifying blood, regulating menstruation and relieving pain, and relaxing tendons and meridians. Puerarin can prevent hydrogen peroxide-mediated endothelial damage by accelerating the transport of complexes required for mitochondrial respiration. It also acts on local tissues, reducing angiotensin II concentrations and inhibiting the expression of angiotensin II and its receptors, thereby achieving vasodilation and blood pressure reduction.

[0016] Gastrodia elata: Sweet in flavor and neutral in nature, it enters the liver meridian, calms wind and stops spasms, calms liver yang, dispels wind and unclogs the meridians, and is a key herb for treating vertigo and headaches. By inhibiting the Ras homolog gene family member A (RhoA) / Rho kinase (ROCK) pathway, gastrodin can effectively reduce tail artery blood pressure, left ventricular hypertrophy index, and serum Ang II and interleukin-6 (IL-6) levels in rats, improving the pathological changes of LVH in hypertensive patients.

[0017] Uncaria rhynchophylla: Sweet in flavor and cooling in nature, it enters the liver and pericardium meridians, and has the effects of lowering blood pressure, regulating heart rate, and inhibiting myocardial hypertrophy. Rhynchophylline exerts its myocardial protection, reverses ventricular remodeling, and improves cardiac function by reducing angiotensin II (AngII) levels and blocking the intracellular signaling pathway of transforming growth factor-β1.

[0018] Semen Cassiae: Sweet, bitter, and salty in flavor, slightly cold in nature, it enters the liver and large intestine meridians and has liver-clearing, eye-improving, bowel-moistening, laxative, lipid-lowering, and antibacterial properties. Semen Cassiae aqueous extract significantly inhibits hypertension and VR in SHR, and also significantly inhibits the migration of SHR-derived VSMCs.

[0019] Prunella vulgaris: It is cold in nature, pungent and bitter in taste, and enters the liver and gallbladder meridians. It has the effects of clearing heat and purging fire, improving eyesight, and dispersing stagnation and swelling. Prunella vulgaris has a dual regulatory effect on blood pressure. Prunella vulgaris decoction can not only lower blood pressure but also improve endothelial function and delay atherosclerosis. Prunella vulgaris extract significantly increases serum NO levels and decreases serum IIIET and An91I levels in SHR rats. This may be due to the reduction of serum endothelin (ET) and angiotensin-converting enzyme II (AngII) levels and the increase in NO concentration, which leads to the antihypertensive effect.

[0020] Angelica sinensis: It promotes blood circulation and replenishes blood, earning it the title of "the qi-regulating and holy medicine of the blood." Angelica sinensis extracts can lower blood pressure through a combination of actions, including receptor and channel activation, reduced renin-angiotensin activity, and lipid and viscosity reduction. Modern pharmacological research in traditional Chinese medicine has identified angelica sinensis volatile oil as its primary active ingredient. Related studies have demonstrated that angelica sinensis volatile oil, when used in spontaneously hypertensive rats, modulates the PI3K / Akt / eNOS signaling pathway in the endothelial system, regulating vasodilation and contraction in SHRs, thereby achieving a certain degree of blood pressure reduction.

[0021] Red peony root: slightly cold in nature and bitter in flavor, it enters the liver and spleen meridians, and has the effects of clearing heat, cooling blood, dispersing blood stasis, and relieving pain. Paeony total glycosides (TPG), a total extract of red peony root, can inhibit platelet activation and inflammatory cytokines, increase serum NO levels, lower blood pressure, and inhibit arterial oxidative stress and MMP-9 levels, improving vascular remodeling in hypertension. It can be used as an adjunct to the treatment of hypertension.

[0022] Gardenia: It has antipyretic, cooling, analgesic, and wind-damp dispelling properties. Modern research indicates that an alcohol extract of Gardenia jasminoides has anticonvulsant, antibacterial, anti-inflammatory, and hypotensive effects. The ethyl acetate fraction of Gardenia jasminoides may reduce the expression of WNK1 and NKCC2, promote urine excretion, lower urine osmotic pressure, and alleviate elevated blood pressure in SHR rats. Studies have shown that an alcohol extract of Gardenia jasminoides exerts its antihypertensive effects by interfering with arginine and proline metabolism, taurine and hypotaurine metabolism, adrenaline metabolism, and phenylalanine metabolism.

[0023] Scutellaria baicalensis: Bitter and cold in nature, it enters the lung, gallbladder, large and small intestine meridians. It has the functions of clearing heat and dampness, purging fire and detoxifying. Modern pharmacological research has shown that it has multiple pharmacological activities, including antibacterial, anti-tumor, antioxidant, cardiovascular and cerebrovascular protection, and antihypertensive activities. The main bioactive components of Scutellaria baicalensis are flavonoids, mainly including baicalin, baicalein, and wogonin. Studies have found that baicalin may reduce hypertension by reducing myocardial cell apoptosis, alleviating myocardial fibrosis, and thereby reducing ventricular remodeling.

[0024] Peach kernel: Bitter, sweet, and neutral in nature, it enters the heart, liver, and large intestine meridians, benefiting from laxative effects and promoting blood circulation and removing blood stasis. Peach kernel and safflower have mild medicinal properties and can be used to treat blood stasis caused by both cold and heat. Modern pharmacological research indicates that the combination of peach kernel and safflower can reduce blood viscosity and inhibit platelet aggregation. Taohong Siwu Decoction has a significant antihypertensive effect, while also protecting myocardial cells, lowering blood lipids, and promoting blood clotting.

[0025] Safflower: Spicy and warm in nature, with a distinctive aroma, it enters the heart and liver meridians, promoting blood circulation, relieving swelling and alleviating pain. Hydroxysafflor yellow A (HSYA), the primary active ingredient in safflower, promotes blood circulation and removes stasis. It can mitigate cold hypoxia / reoxygenation damage to renal tubular epithelial cells by regulating autophagy, mitochondrial function, and antioxidant capacity, protect vascular homeostasis, and regulate blood pressure. It also regulates blood pressure by inhibiting Ca2+ influx and thereby dilating blood vessels, effectively regulating heart function and hypertension.

[0026] Furthermore, the specific component proportions of the traditional Chinese medicine composition include, by weight: 10-15 parts of raw rehmannia, 12-18 parts of chuanxiong, 25-35 parts of salvia miltiorrhiza, 8-12 parts of chuanxiong, 10-14 parts of eucommia, 25-35 parts of kudzu root, 12-18 parts of millettia reticulata, 10-15 parts of gastrodia elata, 10-15 parts of uncaria rhynchophylla, 15-20 parts of sepals, 12-18 parts of selfheal, 12-18 parts of angelica, 12-18 parts of red peony root, 12-18 parts of gardenia, 12-18 parts of scutellaria baicalensis, 10-15 parts of peach kernel, and 12-18 parts of safflower.

[0027] Furthermore, the specific component proportions of the traditional Chinese medicine composition are calculated in grams: 12g of raw rehmannia, 15g of Sichuan cyathula, 30g of salvia miltiorrhiza, 10g of Chuanxiong, 12g of Eucommia ulmoides, 30g of Pueraria root, 15g of Millettia reticulata, 12g of Gastrodia elata, 12g of Uncaria rhynchophylla, 18g of Semen Cassiae, 15g of Prunella vulgaris, 15g of Angelica sinensis, 15g of Red Peony Root, 15g of Gardenia jasminoides, 15g of Scutellaria baicalensis, 12g of peach kernel, and 15g of safflower.

[0028] The present invention also provides an application of the traditional Chinese medicine composition in preparing medicine for treating hypertension.

[0029] Furthermore, the Chinese medicine composition has a blood pressure lowering effect and also has a protective effect on the heart, brain and kidneys.

[0030] Furthermore, the Chinese medicine composition can improve symptoms of headache, dizziness, and chest tightness.

[0031] Furthermore, the dosage forms of the drug include tablets, capsules and oral preparations.

[0032] Furthermore, the oral dosage form includes oral liquid dosage form, oral granules and oral powder dosage form.

[0033] The beneficial effects of the present invention are: Based on traditional Chinese medicine theory, the inventor believes that hypertension in the elderly is also closely related to kidney deficiency and blood stasis, and that kidney deficiency is more important with insufficient kidney yin, and blood stasis is a pathological result. The liver and kidney are of the same origin. If kidney yin is insufficient and water does not contain wood, then liver yang will rise and turn into fire, and yang will be hyperactive in the upper part, blood circulation will be blocked, and blood vessels will be blocked, causing dizziness. If this happens frequently, hypertension will easily develop. If qi and blood flow recklessly and go upward, rush to the brain and out of the collaterals, blood stasis will form and block the collaterals; if fire and heat damage body fluid, blood will be insufficient, or blood stasis will block the collaterals, and the brain will not be able to be nourished, fire will be generated and wind will be generated, causing stroke and endangering life. On the other hand, based on modern pathological research, the inventor believes that the aging and hardening of the blood vessel walls in the elderly will lead to increased perivascular resistance, and usually high blood lipids and a potential state of hypercoagulability, which can lead to long-term high blood pressure and eventually form chronic senile hypertension. Based on the above-mentioned traditional Chinese medicine theory and modern pharmacology research results, the inventors have scientifically designed and optimized the prescription of Chinese medicine combination to address the common chronic disease of hypertension, especially the problem of high systolic blood pressure but low diastolic blood pressure in elderly hypertensive patients. The prescription focuses on promoting blood circulation and unblocking meridians, supplemented by expectorant, heat-clearing and liver-calming products.

[0034] This Chinese medicine composition integrates a variety of Chinese medicinal materials with clear antihypertensive and target organ protection effects, such as Rehmannia glutinosa, Cyathula capitata, Salvia miltiorrhiza, Ligusticum chuanxiong, Eucommia ulmoides, Pueraria lobata, Millettia reticulata, Gastrodia elata, Uncaria rhynchophylla, Semen Cassiae, Prunella vulgaris, Angelica sinensis, Paeonia lactiflora, Gardenia jasminoides, Scutellaria baicalensis, Peach kernel, and Safflower. Through careful combination, Rehmannia is the key medicine for clearing heat, nourishing yin and promoting fluid production, Sichuan Achyranthes leads blood downward and nourishes the liver and kidneys, Salvia miltiorrhiza promotes blood circulation and removes blood stasis, Ligusticum chuanxiong promotes blood circulation and qi, dispels wind and relieves pain, Eucommia ulmoides nourishes the liver and kidneys and strengthens tendons and bones, Pueraria lobata relieves muscles and dispels wind, Millettia reticulata promotes blood circulation and replenishes blood, Gastrodia elata calms wind and stops spasms, and calms liver yang, Uncaria rhynchophylla lowers blood pressure and regulates heart rate, Lithospermum officinale clears the liver and improves eyesight, Prunella vulgaris clears heat and purges fire, Angelica sinensis promotes blood circulation and replenishes blood, Red Peony Root clears heat and cools blood, Gardenia jasminoides relieves heat and cools blood, Scutellaria baicalensis clears heat and dries dampness, Peach Kernel and Safflower promote blood circulation and removes blood stasis, etc. Each medicine complements each other and works together to play the role of lowering blood pressure, improving circulation, and protecting important organs such as the heart, brain, and kidneys.

[0035] This prescription not only adheres to the principles of "holistic thinking" and "differentiation and treatment" in Traditional Chinese Medicine (TCM), precisely targeting the pathological characteristics of kidney deficiency, blood stasis, and hyperactivity of liver yang in elderly patients with hypertension, but also draws on modern pharmacological research on the antihypertensive mechanisms of traditional Chinese medicine ingredients. Tanshinone IIA regulates the renin-angiotensin system in myocardial tissue, myricetin in Chuanxiong regulates phosphorylated AKT and p38 mitogen-activated protein kinase levels, and gastrodin inhibits the RhoA / ROCK pathway, ensuring the scientific and effective nature of the prescription. This allows the traditional Chinese medicine combination to significantly improve symptoms such as headache, dizziness, and chest tightness while lowering blood pressure, thereby improving patients' quality of life. DETAILED DESCRIPTION

[0036] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0037] It should be understood that the terms described herein are intended only to describe particular embodiments and are not intended to limit the present invention. In addition, for numerical ranges herein, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each smaller range between any intermediate value within a stated value or stated range and any other stated value or intermediate value within the stated range is also encompassed by the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the scope.

[0038] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of any conflict with any incorporated document, the contents of this specification shall prevail.

[0039] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from the description of the invention. The description and examples are intended to be exemplary only.

[0040] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0041] The invention provides a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition comprises, by weight, 10-15 parts of raw rehmannia root, 12-18 parts of cyathula root, 25-35 parts of salvia miltiorrhiza root, 8-12 parts of ligusticum chuanxiong, 10-14 parts of eucommia bark, 25-35 parts of kudzu root, 12-18 parts of millettia reticulata, 10-15 parts of gastrodia elata, 10-15 parts of uncaria rhizome, 15-20 parts of cassia bark, 12-18 parts of selfheal, 12-18 parts of angelica sinensis, 12-18 parts of red peony root, 12-18 parts of gardenia jasminoides, 12-18 parts of scutellaria baicalensis, 10-15 parts of peach kernel, and 12-18 parts of safflower.

[0042] The following examples further illustrate the present invention, but should not be construed as limiting the present invention. Without departing from the spirit and substance of the present invention, modifications or substitutions made to the methods, steps or conditions of the present invention are within the scope of the present invention.

[0043] Example 1

[0044] This embodiment provides a traditional Chinese medicine composition for treating hypertension. The prescription ingredients of the traditional Chinese medicine composition include: 12g of raw rehmannia, 15g of Sichuan cyathula, 30g of salvia miltiorrhiza, 10g of Chuanxiong, 12g of Eucommia ulmoides, 30g of Pueraria root, 15g of Millettia reticulata, 12g of Gastrodia elata, 12g of Uncaria rhynchophylla, 18g of Semen Cassiae, 15g of Prunella vulgaris, 15g of Angelica sinensis, 15g of Red Peony Root, 15g of Gardenia jasminoides, 15g of Scutellaria baicalensis, 12g of peach kernel, and 15g of safflower.

[0045] Example 2

[0046] This embodiment provides a traditional Chinese medicine composition for treating hypertension. The prescription ingredients of the traditional Chinese medicine composition include: 10g of raw rehmannia, 12g of Sichuan cyathula, 25g of salvia miltiorrhiza, 8g of Chuanxiong, 10g of Eucommia ulmoides, 25g of Pueraria root, 12g of Millettia reticulata, 10g of Gastrodia elata, 10g of Uncaria rhynchophylla, 15g of Semen Cassiae, 12g of Prunella vulgaris, 12g of Angelica sinensis, 12g of Red Peony Root, 12g of Gardenia jasminoides, 12g of Scutellaria baicalensis, 10g of peach kernel, and 12g of safflower.

[0047] Example 3

[0048] This embodiment provides a traditional Chinese medicine composition for treating hypertension. The prescription ingredients of the traditional Chinese medicine composition include: 15g of raw rehmannia, 18g of Sichuan cyathula, 35g of salvia miltiorrhiza, 12g of Chuanxiong, 14g of Eucommia ulmoides, 35g of Pueraria root, 18g of Millettia reticulata, 15g of Gastrodia elata, 15g of Uncaria rhynchophylla, 20g of Semen Cassiae, 18g of Prunella vulgaris, 18g of Angelica sinensis, 18g of Red Peony Root, 18g of Gardenia jasminoides, 18g of Scutellaria baicalensis, 15g of peach kernel, and 18g of safflower.

[0049] Comparative Example 1

[0050] The only difference between this comparative example and Example 1 is that the component of raw rehmannia is not used in the specific formula.

[0051] Comparative Example 2

[0052] The only difference between this comparative example and Example 1 is that the component of Cyathula capitata is not used in the specific formula.

[0053] Comparative Example 3

[0054] The only difference between this comparative example and Example 1 is that the component Salvia miltiorrhiza is not used in the specific formula.

[0055] Comparative Example 4

[0056] The only difference between this comparative example and Example 1 is that the component Chuanxiong is not used in the specific formula.

[0057] Test Example 1

[0058] The efficacy of the traditional Chinese medicine compositions prepared in Examples 1-3 and Comparative Examples 1-4 was determined, and it was found that Examples 1-3 exhibited a more significant effect in lowering systolic and diastolic blood pressure in hypertensive patients compared to Comparative Example 1. After continuous administration of the traditional Chinese medicine compositions prepared in Examples 1-3 for a period of time, the blood pressure of patients decreased significantly more than that of Comparative Example 1. Specifically, the average decrease in systolic blood pressure in the patients in the Examples 1-3 group was approximately 8-12 mmHg higher than that in the Comparative Example 1 group, and the average decrease in diastolic blood pressure was approximately 6-9 mmHg higher.

[0059] In terms of symptom improvement, the degree of relief of common hypertension symptoms such as dizziness, headache, and tinnitus in patients in Examples 1-3 was also better than that in Comparative Example 1. The majority of patients in Examples 1-3 (approximately 75%-85%) experienced significant symptom relief within two weeks of medication, while only approximately 50%-60% of patients in Comparative Example 1 experienced similar improvement.

[0060] In terms of improving patients' quality of life, the quality of life scores of patients in Examples 1-3 (assessed using a standard quality of life scale) increased significantly. Compared with pre-treatment, the quality of life scores of patients in Examples 1-3 groups increased by an average of 20-25 points, while the average improvement in Control Example 1 group was only 10-15 points.

[0061] Further analysis of its mechanism of action shows that Radix Rehmanniae may play a key role in regulating the balance of yin and yang in the body, nourishing yin and clearing away heat in the Chinese medicine composition. Radix Rehmanniae is rich in a variety of effective ingredients, such as catalpol, rehmannia glutinosa, etc. These ingredients may cooperate with other drugs to jointly play the role of lowering blood pressure and improving symptoms by affecting vascular endothelial function, regulating neurotransmitter release, etc. When Radix Rehmanniae is missing, the synergistic effect of the drug effect of the entire composition is weakened, resulting in the antihypertensive effect and the degree of improvement of symptoms being inferior to Examples 1-3 containing Radix Rehmanniae. This shows that Radix Rehmanniae is an indispensable and important component in the Chinese medicine composition and is of key significance for improving the overall drug effect.

[0062] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not limiting. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the purpose and scope of the technical solutions of the present invention, which should all be covered by the scope of the claims of the present invention.

Claims

1. A Chinese medicine composition for treating hypertension, characterized in that: The traditional Chinese medicine composition comprises the following components: raw rehmannia root, cyathula root, salvia miltiorrhiza, ligusticum chuanxiong, eucommia bark, kudzu root, millettia reticulata, gastrodia elata, uncaria rhynchophylla, cassia bark, prunella vulgaris, angelica root, red peony root, gardenia jasminoides, scutellaria baicalensis, peach kernel and safflower.

2. The Chinese medicine composition according to claim 1, wherein The specific component proportions of the traditional Chinese medicine composition include, by weight: 10-15 parts of raw rehmannia, 12-18 parts of cyathula, 25-35 parts of salvia miltiorrhiza, 8-12 parts of ligusticum chuanxiong, 10-14 parts of eucommia, 25-35 parts of kudzu root, 12-18 parts of millettia reticulata, 10-15 parts of gastrodia elata, 10-15 parts of uncaria rhynchophylla, 15-20 parts of semen cassiae, 12-18 parts of selfheal, 12-18 parts of angelica sinensis, 12-18 parts of red peony root, 12-18 parts of gardenia, 12-18 parts of scutellaria baicalensis, 10-15 parts of peach kernel, and 12-18 parts of safflower.

3. The Chinese medicine composition according to claim 2, wherein The specific component proportions of the traditional Chinese medicine composition are calculated in grams: 12g of raw rehmannia, 15g of Sichuan cyathula, 30g of salvia miltiorrhiza, 10g of Chuanxiong, 12g of Eucommia ulmoides, 30g of Pueraria root, 15g of Millettia reticulata, 12g of Gastrodia elata, 12g of Uncaria rhynchophylla, 18g of Semen Cassiae, 15g of Prunella vulgaris, 15g of Angelica sinensis, 15g of Red Peony Root, 15g of Gardenia jasminoides, 15g of Scutellaria baicalensis, 12g of peach kernel, and 15g of safflower.

4. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating hypertension.

5. The use according to claim 1, characterized in that The traditional Chinese medicine composition has a blood pressure lowering effect and also has a protective effect on the heart, brain and kidneys.

6. The use according to claim 1, wherein The traditional Chinese medicine composition can improve the symptoms of headache, dizziness and chest tightness.

7. The use according to claim 4, characterized in that The dosage forms of the drug include tablets, capsules and oral preparations.

8. The use according to claim 4, characterized in that The oral preparations include oral liquid preparations, oral granules and oral powders.