A heparin sodium product sampling device

Abstract

The application provides a heparin sodium product sampling device, relates to the technical field of detection sampling devices, and comprises a sampling cylinder, a sampling nozzle, a piston and a pull rod, the sampling nozzle is communicated at one end of the sampling cylinder, the piston is slidably installed in the sampling cylinder, and one end of the pull rod is fixedly connected with the piston; a blocking plate is fixedly installed in the sampling nozzle, perforations are formed through the blocking plate, and the sampling nozzle is further provided with two blocking blocks. The application provides a heparin sodium product sampling device, the adjustable one-way valve structure is arranged in the sampling nozzle through the arrangement of the sampling cylinder, the sampling nozzle, the piston, the pull rod, the blocking plate, the two blocking blocks, the elastic reset structure and the adjusting structure, the positions of the two blocking plates are adjusted when sampling or sample extrusion, the entering and flowing out of the sample are ensured at the corresponding stage, the flowing out of the sample from the sampling cylinder during storage or transportation can be reduced, waste and pollution are reduced, the accuracy of detection results is ensured, and the like.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of sampling device, in particular to a heparin sodium product sampling device. BACKGROUND

[0002] Heparin sodium is an anticoagulant, which has the effects of preventing platelet aggregation and destruction, inhibiting fibrinogen conversion into fibrin monomer, inhibiting the formation of thromboplastin and opposing the formed thromboplastin, preventing prothrombin conversion into thrombin and opposing thrombin, etc. It can delay or prevent blood clotting in vivo and in vitro, and is an important anticoagulant in the medical field.

[0003] Heparin sodium has a wide range of applications in the medical field, mainly including: clinical anticoagulation: heparin sodium is mainly used for blood sample collection and anticoagulation in clinical biochemistry and emergency biochemical examination, and is also suitable for blood sample collection and anticoagulation for some blood rheology projects; prevention and treatment of thrombus: heparin sodium is used in clinical practice to prevent the formation of thrombus, other thromboembolic diseases such as myocardial infarction, thrombophlebitis, pulmonary embolism, etc., and disseminated intravascular coagulation caused by various reasons; surgical anticoagulation: heparin sodium can also be used in blood dialysis, extracorporeal circulation catheterization and microvascular surgery operations, as well as the anticoagulation treatment of some blood samples and instruments; therefore, the accurate determination of the purity and content of heparin sodium is crucial for patient safety and efficacy, and the product needs to be sampled for detection.

[0004] When sampling heparin sodium products, a pull-out sampling tube (syringe structure) is usually used to extract heparin sodium products, but the sampling tube may cause the heparin sodium products in the sampling tube to flow out, resulting in waste and pollution, because the sampling port has no plugging structure during actual use. SUMMARY

[0005] Based on the technical problems in the background art, the present application provides a heparin sodium product sampling device.

[0006] The heparin sodium product sampling device provided by the present application comprises a sampling cylinder, a sampling nozzle, a piston and a pull rod, the sampling nozzle is communicated at one end of the sampling cylinder, the piston is slidingly installed in the sampling cylinder, and one end of the pull rod is fixedly connected with the piston.

[0007] A plugging plate is fixedly installed in the sampling nozzle, a through hole is formed through the plugging plate, two plugging blocks are further arranged on the sampling nozzle, there is a gap between the two plugging blocks, the two plugging blocks are located on the two sides of the plugging plate respectively, the diameter of the plugging block is smaller than the inner diameter of the sampling nozzle, the plugging block can plug the through hole on the plugging plate, and an elastic reset structure and an adjusting structure are installed on the sampling nozzle.

[0008] The adjusting structure is used for adjusting one of the two blocking blocks to abut against the blocking plate and block the perforation on the blocking plate.

[0009] When the blocking block abutting against the blocking plate is subjected to an external force to move away from the blocking plate, the elastic reset structure can drive the blocking block to reset to abut against the blocking plate.

[0010] Preferably, the two blocking blocks are fixedly connected with a connecting rod, the connecting rod penetrates the perforation on the blocking plate, and the diameter of the connecting rod is smaller than the diameter of the perforation on the blocking plate.

[0011] Preferably, the elastic reset structure comprises a multi-ribbed cylinder, a sliding block and an elastic assembly; the multi-ribbed cylinder is internally provided with a limiting sliding groove, the sliding block is slidingly installed in the limiting sliding groove, and one end of the connecting rod slidingly penetrates the end of the multi-ribbed cylinder and extends into the limiting sliding groove to be fixedly connected with the sliding block.

[0012] The elastic assembly is used for driving the sliding block to slide and reset in the limiting sliding groove.

[0013] Preferably, the elastic assembly comprises a first spring and a second spring; the first spring and the second spring are both located in the limiting sliding groove, and the first spring and the second spring are respectively located on the two sides of the sliding block.

[0014] Preferably, the adjusting structure comprises a fixed cylinder, a rotating internal threaded cylinder, a threaded block and an adjusting assembly; the fixed cylinder is fixedly installed in the sampling nozzle, the diameter of the fixed cylinder is smaller than the inner diameter of the sampling nozzle, the fixed cylinder is internally provided with a working groove, the rotating internal threaded cylinder is rotationally installed in the working groove, the threaded block is located in the rotating internal threaded cylinder, the threaded block is in threaded cooperation with the rotating internal threaded cylinder, and one end of the multi-ribbed cylinder penetrates the fixed cylinder and extends into the working groove to be fixedly connected with the threaded block.

[0015] Preferably, the adjusting assembly comprises a gear ring, an end face gear, an adjusting rod and an adjusting disc; the gear ring is sleeved on the outer periphery of the rotating internal threaded cylinder, the end face gear is rotationally installed in the fixed cylinder and is in meshing connection with the gear ring, one end of the adjusting rod penetrates the sampling nozzle, the fixed cylinder and the end face gear in sequence to be fixedly connected, and the adjusting disc is fixedly connected to the end of the adjusting rod away from the end face gear.

[0016] Preferably, the cross section of the multi-ribbed cylinder is a regular polygon.

[0017] The heparin sodium product sampling device has the beneficial effects that: the adjustable one-way valve structure is arranged in the sampling nozzle, the positions of the two blocking plates are adjusted when sampling or extruding the sample, the entry and exit of the sample are ensured in the corresponding stage, the sample outflow from the sampling cylinder during storage or transportation is reduced, waste and pollution are reduced, and the accuracy of the detection result is ensured. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 The whole structure schematic view of the heparin sodium product sampling device is provided.

[0019] Figure 2 The sectional view of the heparin sodium product sampling device is provided.

[0020] Figure 3 The position relation between the two blocking blocks and the blocking plate when collecting the sample in the heparin sodium product sampling device is provided.

[0021] Figure 4 The structure schematic view of the two blocking blocks, the connecting rod, the multi-ribbed cylinder and the threaded block in the heparin sodium product sampling device is provided.

[0022] Figure 5 The sectional view of the fixed cylinder and the rotating internal threaded cylinder in the heparin sodium product sampling device is provided.

[0023] Figure 6 The position relation between the two blocking blocks and the blocking plate when extruding the sample in the heparin sodium product sampling device is provided.

[0024] In the figure: 1, sampling cylinder; 2, sampling nozzle; 3, piston; 4, pull rod; 5, blocking plate; 6, blocking block; 7, connecting rod; 8, multi-ribbed cylinder; 9, sliding block; 10, No. 1 spring; 11, No. 2 spring; 12, fixed cylinder; 13, rotating internal threaded cylinder; 14, threaded block; 15, gear ring; 16, end face gear; 17, adjusting rod; 18, adjusting disc. DETAILED DESCRIPTION

[0025] REFERENCE Figures 1-6The application provides a heparin sodium product sampling device, which comprises a sampling cylinder 1, a sampling nozzle 2, a piston 3 and a pulling rod 4, the sampling nozzle 2 is communicated at one end of the sampling cylinder 1, the piston 3 is slidably installed in the sampling cylinder 1, and one end of the pulling rod 4 is fixedly connected with the piston 3; the working principle of the sampling cylinder 1, the sampling nozzle 2, the piston 3 and the pulling rod 4 is similar to the working principle of a syringe, a staff member holds the sampling cylinder 1 with one hand and holds the pulling rod 4 with the other hand, the piston 3 is driven to slide in the sampling cylinder 1 through the pulling rod 4, the air pressure in the sampling cylinder 1 is changed, and the heparin sodium product enters the sampling cylinder 1 from the sampling nozzle 2.

[0026] As shown in Figure 2 , Figure 3 , Figure 4 and Figure 6 , a blocking plate 5 is fixedly installed in the sampling nozzle 2, a through hole is formed in the blocking plate 5, the two ends of the through hole are tapered openings, the sampling nozzle 2 is further provided with two blocking blocks 6, a rubber pad is sleeved on each blocking block 6, there is a gap between the two blocking blocks 6, and the two blocking blocks 6 are located on the two sides of the blocking plate 5 respectively; in actual use, the two blocking blocks 6 are respectively abutted on the two sides of the blocking plate 5, thereby playing the role of one-way valves in two directions in different states, the diameter of the blocking block 6 is smaller than the inner diameter of the sampling nozzle 2, the blocking block 6 can block the through hole in the blocking plate 5, only one of the two blocking blocks 6 can be in contact with the blocking plate 5 at all times, that is, only one of the two blocking blocks 6 can play a role at all times, and the two blocking blocks 6 cannot simultaneously play a blocking role, and the sampling nozzle 2 is provided with an elastic reset structure and an adjusting structure; the adjusting structure is used for adjusting one of the two blocking blocks 6 to abut on the blocking plate 5 and block the through hole in the blocking plate 5; when the blocking block 6 abutting on the blocking plate 5 is subjected to an external force and moves away from the blocking plate 5, the elastic reset structure can drive the blocking block 6 to reset and abut on the blocking plate 5; in the actual operation process, for example, during sampling, the two blocking blocks 6 are adjusted to the state shown in Figure 3 by the adjusting structure, the upper blocking block 6 abuts on the blocking plate 5 and blocks the through hole in the blocking plate 5, so that the upper blocking block 6 cannot continue to drop, when the heparin sodium product is extracted, the air pressure in the sampling cylinder 1 becomes smaller, the external air pressure extrudes the heparin sodium product to enter the sampling cylinder 1 through the sampling nozzle 2, and simultaneously pushes the blocking block 6 to move upward to open the through hole in the blocking plate 5, when the sampling is completed, the upper blocking block 6 is driven to move downward to reset and abut on the blocking plate 5 under the action of the elastic reset structure, and the through hole in the blocking plate 5 is blocked, thereby preventing the heparin sodium product in the sampling cylinder 1 from flowing out, when the heparin sodium product in the sampling cylinder 1 flows out of the sampling nozzle 2, the blocking block 6 cannot move downward, so that the heparin sodium product cannot flow out of the sampling nozzle 2, even if the pulling rod 4 is accidentally squeezed, the heparin sodium product cannot be squeezed out; when the heparin sodium product needs to be squeezed out, the two blocking blocks 6 are adjusted to the state shown in Figure 6 .As shown in the diagram, the lower sealing block 6 blocks the lower opening of the perforation on the sealing plate 5, preventing the sealing block 6 from rising further. External heparin sodium cannot push the sealing block 6 into the sampling cylinder 1. The operator squeezes the pull rod 4, causing the piston 3 to slide inside the sampling cylinder 1. This causes the heparin sodium in the sampling cylinder 1 to exert a downward force on the lower sealing block 6, causing it to move downwards and open the perforation on the sealing plate 5, squeezing out the heparin sodium in the sampling cylinder 1. At this point, the upper sealing block 6 can no longer block the perforation, ensuring that the heparin sodium is squeezed out.

[0027] like Figure 3 and Figure 4 As shown, both sealing blocks 6 are fixedly connected to a connecting rod 7. The axes of the two sealing blocks 6 and the connecting rod 7 coincide. The connecting rod 7 passes through the perforation on the sealing plate 5. The diameter of the connecting rod 7 is smaller than the diameter of the perforation on the sealing plate 5, ensuring that a certain interval is maintained between the two sealing blocks 6. When switching, the interval between the two sealing blocks 6 remains unchanged. When adjusting, the two sealing blocks 6 can be adjusted simultaneously.

[0028] like Figure 3 , Figure 4 and Figure 6 As shown, the elastic reset structure includes a polygonal cylinder 8, a slider 9, and an elastic component. A limiting groove is formed inside the polygonal cylinder 8, with the axis of the limiting groove coinciding with the axis of the polygonal cylinder 8. The slider 9 is slidably installed within the limiting groove. In normal operation, the slider 9 is located in the middle section of the limiting groove. When the slider 9 is subjected to external force, it can move towards both ends of the limiting groove. One end of the connecting rod 7 slides through the end of the polygonal cylinder 8 and extends into the limiting groove, where it is fixedly connected to the slider 9. The elastic component is used to drive the slider 9 within the limiting groove. The slider 9 slides within the limiting groove for reset. The elastic components include a first spring 10 and a second spring 11. Both the first spring 10 and the second spring 11 are located within the limiting groove, and are located on opposite sides of the slider 9. When the slider 9 slides within the limiting groove, it will compress either the first spring 10 or the second spring 11. During reset, the rebound action of the compressed spring drives the slider 9 to slide and reset within the limiting groove, thereby allowing the slider 9 to return to the middle position of the limiting groove.

[0029] like Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6As shown in the drawings, the adjusting structure comprises a fixed cylinder 12, a rotating inner threaded cylinder 13, a threaded block 14 and an adjusting assembly. The outer periphery of the fixed cylinder 12 is fixedly installed on the inner wall of the sampling nozzle 2 by a support. The axis of the fixed cylinder 12 coincides with the axis of the sampling nozzle 2. The diameter of the fixed cylinder 12 is smaller than the inner diameter of the sampling nozzle 2. A working groove is formed in the fixed cylinder 12. The axis of the working groove coincides with the axis of the fixed cylinder 12. The rotating inner threaded cylinder 13 is rotatably installed in the working groove. The axis of the rotating inner threaded cylinder 13 also coincides with the axis of the fixed cylinder 12. The rotating inner threaded cylinder 13 cannot slide in the working groove. The inner peripheral wall of the rotating inner threaded cylinder 13 is provided with threads. The threaded block 14 is located in the rotating inner threaded cylinder 13. The threaded block 14 is threadedly connected with the rotating inner threaded cylinder 13. One end of the multi-ribbed cylinder 8 penetrates through the fixed cylinder 12 and extends into the working groove to be fixedly connected with the threaded block 14. When the rotating inner threaded cylinder 13 rotates, the threaded block 14 threadedly connects with the rotating inner threaded cylinder 13. The cross-sectional view of the multi-ribbed cylinder 8 is a regular hexagon. The multi-ribbed cylinder 8 cannot rotate with the fixed cylinder 12. Because the multi-ribbed cylinder 8 cannot rotate, the threaded block 14 slides in the rotating inner threaded cylinder 13, thereby driving the multi-ribbed cylinder 8 to move synchronously. The multi-ribbed cylinder 8 drives the connecting rod 7 and the two blocking blocks 6 to move synchronously, thereby adjusting the positions of the two blocking blocks 6, so that the two blocking blocks 6 function as one-way valves in two directions.

[0030] As shown in the drawings, Figure 2 , Figure 3 , Figure 5 and Figure 6 , the adjusting assembly comprises a tooth ring 15, an end face gear 16, an adjusting rod 17 and an adjusting disc 18. The tooth ring 15 is sleeved on the outer periphery of the rotating inner threaded cylinder 13. The end face gear 16 is rotatably installed in the fixed cylinder 12. The end face gear 16 is engaged with the tooth ring 15. One end of the adjusting rod 17 penetrates through the sampling nozzle 2, the fixed cylinder 12 and the end face gear 16 in sequence and is fixedly connected with the end face gear 16. The adjusting disc 18 is fixedly connected with the end of the adjusting rod 17 away from the end face gear 16. When the positions of the two blocking blocks 6 are adjusted, the worker pinches the adjusting disc 18 and rotates the adjusting disc 18. The adjusting disc 18 drives the adjusting rod 17 and the end face gear 16 to rotate synchronously. When the end face gear 16 rotates, the end face gear 16 drives the tooth ring 15 to rotate because the end face gear 16 is engaged with the tooth ring 15. The tooth ring 15 drives the rotating inner threaded cylinder 13 to rotate synchronously. The rotating inner threaded cylinder 13 threadedly connects with the threaded block 14, so that the threaded block 14 slides in the rotating inner threaded cylinder 13, thereby changing the positions of the two blocking blocks 6, so that the two blocking blocks 6 function as one-way valves in different directions. For example, when the sampling of the heparin sodium product is performed, the positions of the two blocking blocks 6 and the blocking plate 5 are as shown in Figure 3 . When the heparin sodium product is extruded outward, the positions of the two blocking blocks 6 and the blocking plate 5 are as shown in Figure 6 .

[0031] The sampling work of the heparin sodium product is as follows:

[0032] I. Preparation Phase

[0033] Ensure the work area is clean and tidy, and prepare the necessary sampling tools and equipment, such as sampling tubes, label paper, etc.

[0034] Wear appropriate personal protective equipment, such as gloves, masks, and goggles, to prevent sample contamination or personal injury.

[0035] II. Sampling Steps

[0036] Select samples: From the container storing heparin sodium, select representative samples (e.g. low molecular weight heparin sodium injection, dalteparin sodium, etc.).

[0037] Clean the sampling tools: Before using the sampling tools, ensure they have been cleaned and disinfected to avoid cross-contamination.

[0038] Sampling:

[0039] Use the sampling tube to extract an appropriate amount of heparin sodium solution from the container.

[0040] Labeling: Attach a label to the sampling tube indicating the sample name, sampling date, sampling personnel, etc.; at the same time, record the detailed information of the sampling, such as sampling amount, sampling time, etc.

[0041] III. Subsequent Treatment

[0042] Sample storage: Store the sampled heparin sodium samples under appropriate conditions, such as refrigeration or light protection, to prevent sample deterioration or degradation.

[0043] Sample analysis: According to experimental requirements, send the sampled heparin sodium samples to the laboratory for analysis or detection.

[0044] IV. Matters Needing Attention

[0045] During the sampling process, avoid contamination or cross-contamination of the samples.

[0046] Sampling tools and equipment should be properly cleaned and disinfected.

[0047] Samples should be stored under appropriate conditions to ensure their quality and stability.

[0048] During the sampling process, relevant safety operation procedures and laboratory regulations should be followed.

[0049] Please note that the above steps may vary depending on the specific requirements of the laboratory and the storage conditions of heparin sodium; in actual operation, adjustments and optimizations should be made according to specific circumstances.

[0050] The above merely describes preferred specific embodiments of the present application, but the protection scope of the present application is not limited thereto, and any person skilled in the art, according to the technical solution and inventive concept of the present application, makes equivalent replacement or change within the technical range disclosed by the present application, which should be covered within the protection scope of the present application.

Claims

1. A heparin sodium product sampling device, characterized by, Including sampling cylinder (1), sampling mouth (2), piston (3) and pull rod (4), the sampling mouth (2) is communicated in one end of sampling cylinder (1), the piston (3) is slidably installed in sampling cylinder (1), one end of the pull rod (4) is fixedly connected with piston (3); The blocking plate (5) is fixedly installed in the sampling mouth (2), the perforation is formed in the blocking plate (5), the sampling mouth (2) is provided with two blocking blocks (6), and the two blocking blocks (6) are spaced apart, the two blocking blocks (6) are located on the two sides of the blocking plate (5), the diameter of the blocking block (6) is less than the inner diameter of the sampling mouth (2), the blocking block (6) can block the perforation on the blocking plate (5), the sampling mouth (2) is provided with an elastic reset structure and an adjusting structure; The adjusting structure is used to adjust one of the two blocking blocks (6) to abut against the blocking plate (5) and block the perforation on the blocking plate (5); When the blocking block (6) abutting against the blocking plate (5) is subjected to external force and moves away from the blocking plate (5), the elastic reset structure can drive the blocking block (6) to reset and abut against the blocking plate (5); The two blocking blocks (6) are fixedly connected with a connecting rod (7), the connecting rod (7) penetrates the perforation on the blocking plate (5), and the diameter of the connecting rod (7) is less than the diameter of the perforation on the blocking plate (5); The elastic reset structure comprises a multi-ribbed cylinder (8), a sliding block (9) and an elastic assembly, the multi-ribbed cylinder (8) is provided with a limiting sliding groove, the sliding block (9) is slidably installed in the limiting sliding groove, one end of the connecting rod (7) slidably penetrates the end of the multi-ribbed cylinder (8) and extends into the limiting sliding groove and is fixedly connected with the sliding block (9); The elastic assembly is used to drive the sliding block (9) to slide and reset in the limiting sliding groove; The adjusting structure comprises a fixed cylinder (12), a rotating internal threaded cylinder (13), a threaded block (14) and an adjusting assembly, the fixed cylinder (12) is fixedly installed in the sampling mouth (2), the diameter of the fixed cylinder (12) is less than the inner diameter of the sampling mouth (2), the fixed cylinder (12) is provided with a working groove, the rotating internal threaded cylinder (13) is rotatably installed in the working groove, the threaded block (14) is located in the rotating internal threaded cylinder (13), the threaded block (14) is threadedly connected with the rotating internal threaded cylinder (13), one end of the multi-ribbed cylinder (8) penetrates the fixed cylinder (12) and extends into the working groove and is fixedly connected with the threaded block (14); The adjusting assembly comprises a gear ring (15), an end face gear (16), an adjusting rod (17) and an adjusting disc (18), the gear ring (15) is sleeved on the outer periphery of the rotating internal threaded cylinder (13), the end face gear (16) is rotatably installed in the fixed cylinder (12), and the end face gear (16) is engaged with the gear ring (15), one end of the adjusting rod (17) penetrates the sampling mouth (2), the fixed cylinder (12) and the end face gear (16) in sequence and is fixedly connected, and the adjusting disc (18) is fixedly connected to one end of the adjusting rod (17) away from the end face gear (16).

2. The heparin sodium product sampling device according to claim 1, characterized in that, The elastic assembly comprises a first spring (10) and a second spring (11); the first spring (10) and the second spring (11) are located in the limiting sliding groove, and the first spring (10) and the second spring (11) are respectively located on the two sides of the sliding block (9).

3. The heparin sodium product sampling device according to claim 1, wherein The cross-sectional view of the multi-ribbed cylinder (8) is a regular polygon.

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