Reaction kettle for processing drug intermediates

Abstract

The invention relates to the technical field of intermediate processing equipment, in particular to a reaction kettle for drug intermediate processing, which comprises a rack and a reaction kettle body arranged on the rack, and a cleaning assembly for cleaning residues remaining on the inner wall of the reaction kettle body is arranged on a stirring assembly. The stirring assembly comprises a stirring motor fixed to the rack and a stirring shaft fixed to the stirring motor, the cleaning assembly comprises a moving rod arranged on the stirring shaft in a sleeving mode and a cleaning ring arranged on the moving rod, a plurality of cleaning holes are formed in the cleaning ring, a liquid inlet is formed in the lower end of the stirring shaft, and a liquid outlet is formed in the lower end of the cleaning ring. A one-way elastic piece for blocking an opening in the lower end of the stirring shaft is arranged at a liquid inlet in the lower end of the stirring shaft, and a liquid pumping assembly for pumping liquid in the reaction kettle body into the hollow stirring shaft is arranged on the stirring shaft. The reaction kettle has the effect that liquid in the reaction kettle body is heated more uniformly.

Description

Technical Field

[0001] The present application relates to the technical field of intermediate processing equipment, and in particular to a reactor for processing pharmaceutical intermediates. Background Art

[0002] Pharmaceutical intermediates are essentially high-tech, high-value-added, and specialized chemical raw materials or products used in pharmaceutical synthesis processes. With the continuous improvement of people's living standards and the continuous upgrading of pharmaceuticals, the demand for intermediates is increasing. Reactors are generally used in the production of pharmaceutical intermediates. Reactors are equipment used for chemical reactions, typically made of high-temperature, pressure-resistant, and corrosion-resistant materials such as stainless steel, fiberglass, and titanium alloys. They can accommodate reactants and catalysts and provide appropriate temperature, pressure, stirring, and control conditions to promote the reaction. Through the structural design and parameter configuration of the reactor, the heating, evaporation, cooling, and low-speed mixing functions required by the process can be achieved.

[0003] For example, a Chinese patent document with publication number CN220940606U discloses a reactor for synthesizing pharmaceutical intermediates, comprising: a reactor shell, a plurality of brackets fixedly connected to the bottom of the reactor shell, a top cover fixedly connected to the top of the bracket, a fixed plate fixedly connected to the top of the top cover, a motor provided on the top of the fixed plate, wherein: a rotating rod is provided inside the reactor shell, the rotating rod passes through the fixed plate and is connected to the bottom of the motor, a catalyst box is fixedly connected to the side wall of the rotating rod, a spiral stirring tube is fixedly connected to one side of the catalyst box, the spiral stirring tube is surrounded by the side wall of the rotating rod, and a plurality of catalyst discharge ports are provided on the side wall of the spiral stirring tube; an upper circulation port is provided on the top side wall of the reactor shell, a lower circulation port is provided on the bottom side wall of the reactor shell, a circulation pipe is provided around the side wall of the reactor shell, and the two ends of the circulation pipe are respectively connected to the upper circulation port and the lower circulation port. First, place a sufficient amount of catalyst in the catalyst box. After the preparation work is completed, place the substance to be reacted into the reactor shell through the feed port, turn on the motor, and use the power provided by the motor to drive the rotating rod to rotate. The catalyst in the catalyst box will flow into the spiral stirring tube. The catalyst discharge port opened on the spiral stirring tube will directly contact the substance in the reactor shell. The rotation of the rotating rod will drive the spiral stirring tube to rotate. The action of the spiral stirring tube will allow the substance and catalyst to fully contact and mix.

[0004] In the above-mentioned related technologies, the spiral stirring tube is driven to rotate by a rotating rod, and the action of the spiral stirring tube allows the substance and the catalyst to fully contact and mix. However, when the double-layer reactor reacts in the intermediate, since a heating medium is provided in the interlayer of the reactor, during the heating process, a portion of viscous liquid will adhere to the inner wall of the reactor. This viscous liquid will increase the thermal resistance, slow down the entry of heat into the interior of the reactor, and then cause the liquid in the reactor to be heated unevenly, thereby increasing the reaction time of the liquid inside the reactor. Summary of the Invention

[0005] The present application provides a reactor for processing pharmaceutical intermediates, aiming to solve the problem of uneven heating of the liquid inside the reactor in the related art.

[0006] The present application provides a reactor for processing pharmaceutical intermediates using the following technical solutions: The stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame. The stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame. The stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame. The stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame. The stirring mechanism is fixed on the frame, and the stirring mechanism is fixed on the frame.

[0007] By adopting the above technical solution, in the initial state, the lower end of the liquid pumping rod is at the lowest part of the stirring shaft, and then the liquid inlet at the lower end of the stirring shaft is blocked by the one-way spring piece. When blocked, the liquid in the reactor body cannot enter the stirring shaft. When the inner wall of the reactor body needs to be cleaned, the driving assembly drives the moving rod to move upward, and the upward moving rod drives the cleaning ring to move upward. During the upward movement, the liquid pumping assembly pumps the liquid in the reactor body into the hollow stirring shaft. The one-way spring piece tilts upward, the liquid inlet of the stirring shaft is opened, and the liquid in the reactor body is sucked into the bellows; when the cleaning ring moves to the top, the liquid pumping assembly needs to move downward, and then the liquid in the stirring shaft is pushed out through the cleaning hole. The liquid sprayed from the cleaning hole will clean the inner wall of the reactor body, thereby reducing the liquid residue on the inner wall of the reactor body, and can make the liquid in the reactor body more evenly heated.

[0008] Optionally, the liquid pumping assembly includes a bellows arranged in the stirring shaft and a liquid pumping rod slidably connected to the stirring shaft, and a mounting assembly is provided on the liquid pumping rod, and the liquid pumping rod is fixed to the moving rod through the mounting assembly, one end of the bellows is fixed to the opening at the lower end of the stirring shaft, and the other end is fixed to the liquid pumping rod, and the liquid pumping rod is fixed to the moving rod through the mounting assembly.

[0009] By adopting the above technical solution, when it is necessary to clean the inner wall of the reactor body, the moving rod is directly moved upward. During the upward movement of the moving rod, the liquid pumping rod is driven to move upward. During the upward movement of the liquid pumping rod, the bellows is driven to be stretched, and then the liquid in the reactor body is sucked into the bellows from the liquid inlet. Then, when it is necessary to clean the inner wall of the reactor body, the liquid pumping rod is moved downward, and the downward moving liquid pumping rod drives the cleaning ring to move downward. Since the liquid inlet is blocked by the one-way spring piece, the liquid pumping rod will squeeze the liquid in the bellows, and the length of the bellows will gradually decrease. Then the liquid inside will be squeezed into the cleaning ring, and finally sprayed out from the cleaning hole on the cleaning ring, so as to facilitate the cleaning of the inner wall of the reactor body.

[0010] Optionally, the cleaning ring is provided with a connecting assembly for connecting the cleaning ring and the moving rod, the connecting assembly includes a connecting ring fixed on the moving rod and a connecting tube fixed on the connecting ring, the connecting ring is configured as a hollow structure, one end of the connecting tube is used to communicate with the cleaning ring, and the other end is used to connect with the cavity of the connecting ring.

[0011] By adopting the above technical solution, the cleaning ring is fixed on the moving rod through the connecting pipe and the connecting ring, and then the cleaning ring can be driven to move during the up and down movement of the moving rod, thereby making it more convenient to adjust the cleaning ring.

[0012] Optionally, the connecting pipe is arranged at an angle, and the connecting ring is arranged above the cleaning ring.

[0013] By adopting the above technical solution, since the connecting pipe is set at an angle, after the liquid in the reactor body is discharged, the liquid in the connecting ring and the connecting pipe will enter the cleaning ring and finally be discharged through the cleaning hole on the cleaning ring, thereby reducing the liquid residue in the cleaning ring and the cleaning pipe.

[0014] Optionally, the mounting assembly includes a mounting block fixed on the pumping rod and a communicating hole provided on the mounting block, the mounting block is fixedly mounted on the connecting ring, the communicating hole is used to connect the cavity of the connecting ring with the chamber in the bellows, and in the process of the moving rod driving the connecting ring to move, the connecting ring will drive the pumping rod to move and the bellows to expand and contract.

[0015] By adopting the above technical solution, the pumping rod is fixed on the connecting ring through the mounting block. Then, during the up and down movement of the moving rod, the moving rod drives the connecting ring and the mounting block set on the connecting ring to move, and finally drives the pumping rod to move, thereby achieving the purpose of facilitating the movement of the pumping rod.

[0016] Optionally, an adjusting component is provided on the mounting block, and the adjusting component is used to adjust the size of the communicating hole. When the opening of the communicating hole is maximum, the pressure of the liquid sprayed from the cleaning hole is minimum; the adjusting component includes an adjusting shaft fixedly mounted on the inner wall of the communicating hole and an adjusting plate rotatably connected to the adjusting shaft, and a pushing component for pushing the adjusting plate to rotate is provided on the connecting ring. In the process of the pushing component pushing the adjusting plate to rotate, the opening of the communicating hole becomes smaller, the pressure of the liquid entering the connecting ring becomes larger, and the pressure of the liquid sprayed from the cleaning hole becomes larger.

[0017] By adopting the above technical solution, the cleaning ring will move into the liquid in the reactor body during the up and down movement. At this time, it is necessary to increase the pressure of the liquid sprayed from the cleaning hole so that the pressure of the liquid sprayed can overcome the resistance of the liquid in the reactor body. By rotating the adjusting plate, the opening of the connecting hole on the mounting block becomes smaller, and then the pressure of the liquid entering the connecting pipe becomes larger, and the pressure of the liquid sprayed from the cleaning hole will also become larger. When the cleaning ring moves out the liquid, it is necessary to reduce the pressure of the liquid sprayed, thereby reducing the impact force of the liquid on the reactor body. It is only necessary to rotate the adjusting plate to enlarge the opening on the connecting ring, and then reduce the pressure of the liquid entering the connecting pipe, thereby reducing the pressure of the sprayed liquid.

[0018] Optionally, a torsion spring is sleeved on the adjusting shaft, one end of the torsion spring is fixed on the adjusting shaft, and the other end is fixed on the adjusting plate.

[0019] By adopting the above technical solution, when the adjustment plate is pushed to rotate upward, the opening on the connecting hole becomes smaller. When the pushing block moves in the opposite direction, the torsion spring drives the adjustment plate to rotate in the opposite direction, and the opening on the connecting hole becomes larger.

[0020] Optionally, the pushing assembly includes a limit rod slidably connected to the mounting block, a pushing block fixed on the limit rod, a pushing shaft fixed on the pushing block, and a pushing bar fixed on the inner wall of the give way groove, the pushing bar is provided with a pushing inclined surface, the limit rod slides horizontally on the mounting block, and the sliding direction of the limit rod is perpendicular to the axis of the adjusting shaft, the axis of the pushing shaft is arranged parallel to the axis of the adjusting shaft, and the pushing shaft is arranged perpendicular to the limit rod, and the side surface of the pushing shaft abuts against the pushing inclined surface, and when the mounting block and the moving rod move downward, the pushing inclined surface will push the pushing shaft to move in the direction of the axis close to the stirring shaft.

[0021] Optionally, the driving assembly includes a driving sleeve fixed on the frame and a driving rod fixed on the moving rod, a thread groove is provided on the inner wall of the driving sleeve, and the driving rod is slidably connected in the thread groove.

[0022] By adopting the above technical solution, during the rotation of the stirring shaft, the moving rod will be driven to rotate at the same time, and the rotation of the moving rod will drive the driving rod to rotate. Under the action of the threaded groove, the moving rod will be driven to move up and down, and during the up and down movement of the moving rod, the pumping rod will be driven to move, thereby facilitating the adjustment of the position of the pumping rod and the cleaning ring on the moving rod.

[0023] Optionally, an inclined surface is provided on the lower surface of the adjustment plate, and an arcuate surface is provided on the pushing block, and the arcuate surface is used to abut against the inclined surface.

[0024] In summary, this application includes at least one of the following beneficial technical effects: 1. The pumping rod moves downward, and the downward-moving pumping rod drives the cleaning ring to move downward. The pumping rod will squeeze the liquid in the bellows. As the length of the bellows gradually decreases, the liquid inside will be squeezed into the cleaning ring and finally sprayed out from the cleaning hole on the cleaning ring, making it easier to clean the inner wall of the reactor body.

[0025] 2. When the cleaning ring removes the liquid, it is necessary to reduce the pressure of the liquid spraying out, thereby reducing the impact force of the liquid on the reactor body. You only need to turn the adjustment plate to make the opening on the connecting ring larger, and then the pressure of the liquid entering the connecting pipe will decrease, thereby reducing the pressure of the sprayed liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a cross-sectional view of the reactor of an embodiment of the present application.

[0027] Figure 2 This is a cross-sectional view of the stirring shaft of an embodiment of the present application.

[0028] Figure 3 It is a schematic diagram of the drive sleeve and drive rod structure of an embodiment of the present application.

[0029] Figure 4 It is a schematic diagram of the cleaning ring structure of an embodiment of the present application.

[0030] Figure 5 yes Figure 4 Enlarged view of point A in the middle.

[0031] Figure 6 yes Figure 4 Enlarged view of point B in the middle.

[0032] Figure 7 It is a three-dimensional diagram of the cleaning component of an embodiment of the present application.

[0033] Figure 8 yes Figure 7 Enlarged view of point C in the middle.

[0034] 1. Stirring assembly; 1. Stirring motor; 1. Stirring shaft; 2. Cleaning assembly; 3. Moving rod; 4. Cleaning ring; 5. Cleaning hole; 6. Pumping assembly; 7. Bellows; 8. Pumping rod; 9. Driving assembly; 10. Driving sleeve; 11. Driving rod; 12. Threaded groove; 13. Mounting assembly; 14. Mounting block; 15. Connecting hole; 16. Connecting assembly; 17. Connecting pipe; 18. Connecting ring; 19. Adjusting assembly; 20. Adjusting shaft; 21. Stirring motor; 22. Stirring shaft; 23. Cleaning hole; 24. Pumping assembly; 25. Bellows; 26. Pumping rod; 27. Driving sleeve; 28. Driving rod; 29. ​​Threaded groove; 30. Mounting assembly; 31. Mounting block; 32. Connecting hole; 31. Connecting assembly; 32. Connecting pipe; 33. Connecting ring; 34. Adjusting assembly; 35. Adjusting shaft; 36. Adjusting plate; 37. Torsion spring; 38. Pushing assembly; 39. Limiting rod; 40. Pushing block; 41. Pushing shaft; 42. Pushing bar; 43. Pushing inclined plane; 44. Inclined surface; 45. Arc surface. DETAILED DESCRIPTION

[0035] The following combination Figures 1-8 This application is described in further detail.

[0036] The present application discloses a reactor for processing pharmaceutical intermediates. Figure 1 and Figure 2 A reactor for processing pharmaceutical intermediates includes a frame 01 and a reactor body 02 arranged on the frame 01. A stirring component 1 is arranged on the reactor body 02, and the stirring component 1 is used to stir the pharmaceutical intermediate in the reactor body 02. At the same time, a cleaning component 2 is arranged on the stirring component 1, and the cleaning component 2 is used to clean the residue remaining on the inner wall of the reactor body 02, and then reduce the residue attached to the inner wall of the reactor body 02, so that the pharmaceutical intermediate in the reactor body 02 is heated more evenly.

[0037] Reference Figure 1 and Figure 2The stirring assembly 1 includes a stirring motor 11 fixed on the frame 01, a stirring shaft 12 fixed on the stirring motor 11, and a stirring blade (not shown in the figure) fixed on the stirring shaft 12. The stirring blade is arranged at the bottom of the stirring shaft 12, and the stirring shaft 12 is rotatably connected to the reactor body 02. In this embodiment, the reactor body 02 is arranged to have a double-layer glass structure, and heat transfer oil can be introduced between the double-layer glass. The heat transfer oil can heat or cool the drug intermediate in the reactor body 02. At the same time, a liquid inlet pipe and a liquid outlet pipe are provided on the reactor body 02. The liquid inlet pipe is arranged above the reactor body 02, and the liquid outlet pipe is arranged below the reactor body 02. The object to be reacted is placed into the reactor body 02 through the liquid inlet pipe, and then heated by the heat transfer oil. The stirring motor 11 drives the stirring shaft 12 and the stirring blade fixed on the stirring shaft 12 to rotate, so as to mix and stir the drug intermediate in the reactor body 02.

[0038] Reference Figures 1 to 5 The cleaning assembly 2 includes a moving rod 21 sleeved on the stirring shaft 12 and a cleaning ring 22 fixed on the moving rod 21. The cleaning ring 22 is provided with a plurality of cleaning holes 23. At the same time, a driving assembly 4 for driving the moving rod 21 to move up and down is provided on the frame 01.

[0039] Reference Figures 1 to 5 The stirring shaft 12 is set to a hollow structure, and a liquid inlet 03 is opened at the lower end of the stirring shaft 12. At the same time, a liquid pumping component 3 is provided on the stirring shaft 12. The liquid pumping component 3 is used to pump the liquid in the reactor body 02 into the hollow stirring shaft 12, and then push the liquid in the stirring shaft 12 into the cleaning ring 22, and finally spray it onto the inner wall of the reactor body 02 through the cleaning hole 23 on the cleaning ring 22. The liquid sprayed from the cleaning hole 23 will clean the inner wall of the reactor body 02. During the cleaning process, the liquid will be reduced from adhering to the inner wall of the reactor body 02. In the process of the driving component 4 driving the cleaning ring 22 to move up and down, different positions of the inner wall of the reactor body 02 can be cleaned, and then the liquid inside the reactor body 02 can be heated more evenly.

[0040] Reference Figures 1 to 5The driving assembly 4 includes a driving sleeve 41 fixed on the frame 01 and a driving rod 42 fixed on the moving rod 21. A threaded groove 43 is provided on the inner wall of the driving sleeve 41. The driving rod 42 is slidably connected in the threaded groove 43. When the stirring motor 11 drives the stirring shaft 12 to rotate, the stirring shaft 12 will drive the moving rod 21 to rotate. When the moving rod 21 rotates, the driving rod 42 will be driven to rotate. Then, under the action of the threaded groove 43, the moving rod 21 on the stirring shaft 12 can be moved up and down. When the moving rod 21 moves up and down, the cleaning ring 22 will be driven up and down. Then, under the action of the liquid pumping assembly 3, the liquid can be pushed out from the cleaning hole 23. The liquid sprayed from the cleaning hole 23 can clean the inner wall of the reactor body 02.

[0041] Reference Figures 1 to 6 The liquid pumping assembly 3 includes a bellows 31 arranged in the stirring shaft 12 and a liquid pumping rod 32 slidably connected to the stirring shaft 12. The liquid pumping rod 32 is provided with a mounting assembly 5, and then the liquid pumping rod 32 is fixed to the moving rod 21 through the mounting assembly 5. One end of the bellows 31 is fixed to the liquid inlet 03 at the lower end of the stirring shaft 12, and the other end is fixed to the liquid pumping rod 32. Since the liquid pumping rod 32 is fixed to the moving rod 21 through the mounting assembly 5, a clearance groove 04 for the sliding of the mounting assembly 5 is opened on the stirring shaft 12. The clearance groove 04 is arranged along the length direction of the stirring shaft 12. There are multiple clearance grooves 04, and multiple clearance grooves 04 are arranged at intervals along the circumference of the stirring shaft 12. Then the bellows 31 in the stirring shaft 12 can block the clearance groove 04 on the stirring shaft 12 to prevent liquid from entering the hollow stirring shaft 12.

[0042] Reference Figures 1 to 5 A mounting ring 05 is fixedly installed at the liquid inlet 03 at the lower end of the stirring shaft 12, and a one-way spring piece 06 is provided on the mounting ring 05. The one-way spring piece 06 is used to seal the liquid inlet 03 at the lower end of the stirring shaft 12. One end of the one-way spring piece 06 is fixed on the mounting ring 05. Under the elastic force of the one-way spring piece 06, in the initial state, the one-way spring piece 06 is tightly attached to the surface of the mounting ring 05, and then the liquid in the reactor body 02 cannot enter the stirring shaft 12 through the liquid inlet 03 at the lower end of the stirring shaft 12.

[0043] When it is necessary to extract the liquid in the reactor body 02 into the stirring shaft 12, the driving component 4 drives the moving rod 21 to move upward, and the moving rod 21 that moves upward drives the liquid extraction rod 32 to move upward through the mounting component 5. In the process of the liquid extraction rod 32 moving upward, the bellows 31 will be expanded. At the same time, due to the effect of suction, the one-way spring piece 06 will tilt upward. In the process of the one-way spring piece 06 tilting, it no longer abuts against the surface of the mounting ring 05. Then, in the process of the liquid extraction rod 32 moving upward, the liquid in the reactor body 02 will be sucked into the bellows 31. After the bellows 31 is fully expanded, the driving component 4 moves the moving rod 21 downward. The downward moving rod 21 will drive the liquid pumping rod 32 and the cleaning ring 22 to move downward, and the liquid in the bellows 31 will be squeezed at this time. The liquid in the bellows 31 enters the cleaning ring 22 through the mounting assembly 5, and finally is sprayed toward the inner wall of the reactor body 02 through the cleaning hole 23 on the cleaning ring 22. In the process of pushing the liquid pumping rod 32 downward, the bellows 31 is compressed. At the same time, the liquid in the bellows 31 will push the one-way spring piece 06 to seal the opening of the stirring shaft 12, so that the liquid in the bellows 31 cannot flow out from the opening of the stirring shaft 12, and can only be discharged from the cleaning hole 23 on the cleaning ring 22.

[0044] Reference Figures 2 to 7 A connecting assembly 6 is provided on the cleaning ring 22, and the connecting assembly 6 is used to connect the cleaning ring 22 and the moving rod 21. In this embodiment, a plurality of cleaning holes 23 are provided on the cleaning ring 22, and the plurality of cleaning holes 23 are arranged at intervals along the circumference of the cleaning ring 22. The connecting assembly 6 includes a connecting ring 62 fixed on the moving rod 21 and a connecting ring 62 fixed on the connecting ring 62. The connecting ring 62 is set to a hollow structure. One end of the connecting pipe 61 is used to communicate with the cleaning ring 22, and the other end is used to connect with the cavity of the connecting ring 62.

[0045] Reference Figures 2 to 7 The mounting assembly 5 includes a mounting block 51 fixed on the pumping rod 32 and a communicating hole 52 opened on the mounting block 51. The mounting block 51 is fixedly mounted on the connecting ring 62, and the communicating hole 52 is used to connect the cavity of the connecting ring 62 and the chamber in the bellows 31. The mounting block 51 on the pumping rod 32 is slidably connected in the give way groove 04. Since the mounting block 51 is fixedly connected to the connecting ring 62, when the moving rod 21 drives the connecting ring 62 to move, the connecting ring 62 will drive the pumping rod 32 to move and the bellows 31 to expand and contract. A plurality of mounting blocks 51 are provided, and the plurality of mounting blocks 51 correspond one to one to the plurality of give way grooves 04.

[0046] In the initial state, the cleaning ring 22 is at the bottom of the reactor body 02. When the driving assembly 4 drives the moving rod 21 to move upward, the moving rod 21 drives the connecting ring 62 to move upward, and the upward connecting ring 62 drives the connecting pipe 61 and the cleaning ring 22 to move upward. Since the mounting block 51 is clamped on the connecting ring 62, the pumping rod 32 is also driven to move upward. During the upward movement of the pumping rod 32, the bellows 31 is extended, and the one-way spring piece 06 is tilted upward. The one-way spring piece 06 is spaced apart from the surface of the mounting ring 05. Then, the liquid in the reactor body 02 is sucked into the bellows 31 through the opening of the stirring shaft 12. When the cleaning ring 22 moves to the upper side, The driving assembly 4 drives the moving rod 21 to move downward, and the downward moving rod 21 drives the connecting ring 62 and the liquid pumping rod 32 set on the connecting ring 62 to move downward. The liquid pumping rod 32 will push the liquid in the bellows 31 into the cavity of the connecting ring 62 through the connecting hole 52, and then enter the connecting pipe 61 and the cleaning ring 22 through the cavity of the connecting ring 62, and finally be sprayed out through the cleaning hole 23 on the cleaning ring 22. The sprayed liquid will clean the side wall of the reactor body 02, and then reduce the liquid remaining on the inner wall of the reactor body 02, thereby improving the thermal conductivity of the inner wall of the reactor body 02, so that the liquid in the reactor body 02 is heated more evenly.

[0047] In this embodiment, the connecting tube 61 is arranged at an angle, and the height of the connecting ring 62 is higher than the height of the cleaning ring 22. When the liquid in the reactor body 02 is completely discharged, the liquid pumping rod 32 is at the bottom, and the bellows 31 is in a compressed state. Then, the liquid in the connecting ring 62 and the connecting tube 61 will enter the cleaning ring 22 under the action of gravity, and then the liquid in the cleaning ring 22 will flow out from the cleaning hole 23 under the action of gravity, thereby achieving the purpose of facilitating the cleaning of the liquid in the cleaning ring 22, thereby reducing the liquid residue in the connecting ring 62, the connecting tube 61 and the cleaning ring 22.

[0048] Reference Figures 4 to 8 An adjustment component 7 is provided on the mounting block 51. The adjustment component 7 is used to adjust the size of the communicating hole 52. When the opening of the communicating hole 52 is the largest, the pressure of the liquid entering the connecting ring 62 is the smallest, and then the pressure of the liquid entering the connecting ring 62, the connecting pipe 61 and the cleaning ring 22 will also be the smallest. Finally, the pressure of the liquid ejected from the cleaning hole 23 is the smallest. At this time, the impact on the inner wall of the reactor body 02 can be reduced, thereby playing a role in protecting the inner wall of the reactor body 02.

[0049] When the cleaning ring 22 is in the liquid of the reactor body 02, in order to facilitate the liquid sprayed from the cleaning hole 23 to clean the liquid on the inner wall of the reactor body 02, the pressure of the liquid sprayed from the cleaning hole 23 needs to be increased. After the pressure increases, it overcomes the resistance of the liquid in the reactor body 02, and then the inner wall of the reactor body 02 can be better cleaned. When the cleaning ring 22 is above the liquid in the reactor body 02, the connecting hole 52 is maximized, and then the pressure of the liquid sprayed from the cleaning hole 23 is minimized, thereby reducing the damage of the liquid to the reactor body 02.

[0050] Reference Figures 4 to 8 When the lock body 71 is unlocked, the lock body 7 is unlocked, and the lock body 7 is unlocked, so that the lock body 7 can be unlocked. If the lock body 7 is unlocked, the lock body 7 can be unlocked, and the lock body 7 can be unlocked.

[0051] Reference Figures 4 to 8 The pushing assembly 8 includes a limiting rod 81 slidably connected to the mounting block 51, a pushing block 82 fixed on the limiting rod 81, a pushing shaft 83 fixed on the pushing block 82, and a pushing bar 84 fixed on the inner wall of the give way groove 04. The pushing bar 84 is provided with a pushing inclined surface 85. The limiting rod 81 slides horizontally on the mounting block 51, and the sliding direction of the limiting rod 81 is perpendicular to the axis of the adjusting shaft 71. The axis of the pushing shaft 83 is arranged parallel to the axis of the adjusting shaft 71, and the pushing shaft 83 is arranged perpendicular to the limiting rod 81, and the side of the pushing shaft 83 abuts against the pushing inclined surface 85.

[0052] The adjusting plate 72 will rotate in the opposite direction under the action of the torsion spring 73, thereby making it more convenient to adjust the position of the adjusting plate 72.

[0053] In order to facilitate the rotation of the push adjustment plate 72, an inclined surface 9 is provided on the lower surface of the adjustment plate 72, and a curved surface 91 is provided on the push block 82. The curved surface 91 is used to abut against the inclined surface 9. When the push block 82 slides horizontally toward the axis of the stirring shaft 12, the curved surface 91 on the push block 82 will push the adjustment plate 72 to rotate upward. During the rotation, the opening size of the communicating hole 52 will be adjusted. Under the action of the curved surface 91, the friction between the push block 82 and the adjustment plate 72 can be reduced, making the rotation of the push adjustment plate 72 more convenient. The implementation principle of a reactor for processing pharmaceutical intermediates in an embodiment of the present application is as follows: when reacting the pharmaceutical intermediates, the raw materials need to be added into the reactor body 02 in sequence through the feed port, and the raw materials added into the reactor body 02 are rotated by the stirring blades. At the same time, the heat transfer oil between the double-layer reactor body 02 heats the raw materials in the reactor body 02. During the heating and stirring process, part of the raw materials will be swirled, and the swirled raw materials will adhere to the inner wall of the reactor body 02. At the same time, during the heating process, the inner wall of the reactor body 02 that is in contact with the raw materials will also be stuck with the raw materials.

[0054] During the rotation of the stirring shaft 12, the moving rod 21 is driven to rotate at the same time, and the moving rod 21 is driven to move upward under the action of the driving sleeve 41 and the threaded groove 43. During the upward movement of the moving rod 21, the pumping rod 32 and the cleaning ring 22 are driven to move upward. During the upward movement, the compressed bellows 31 is stretched, and due to the effect of suction, the one-way spring 06 is tilted upward, and then a gap is formed between it and the mounting ring 05. The liquid in the reactor body 02 enters the bellows 31 through the gap between the mounting ring 05 and the one-way spring 06. After being fully stretched, the cleaning ring 22 moves to the top, and the bellows 31 is filled with liquid. At this time, the driving sleeve 41 drives the moving rod 21 to move downward, and the downward moving rod 21 will drive the cleaning ring 22 and the liquid pumping rod 32 to move downward. The downward liquid pumping rod 32 will push the liquid in the bellows 31 into the cleaning ring 22 through the connecting hole 52, and finally be sprayed out from the cleaning hole 23. The sprayed liquid cleans the inner wall of the reactor body 02, thereby reducing the liquid remaining on the inner wall of the reactor body 02, so that the liquid in the reactor body 02 is heated more evenly.

[0055] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A reactor for processing pharmaceutical intermediates, comprising a frame (01) and a reactor body (02) arranged on the frame (01), wherein the reactor body (02) is provided with a stirring assembly (1) for stirring the pharmaceutical intermediate, characterized in that: The stirring assembly (1) is provided with a cleaning assembly (2) for cleaning residues remaining on the inner wall of the reactor body (02). The stirring assembly (1) includes a stirring motor (11) fixed on the frame (01) and a stirring shaft (12) fixed on the stirring motor (11). The cleaning assembly (2) includes a moving rod (21) sleeved on the stirring shaft (12) and a cleaning ring (22) provided on the moving rod (21). The cleaning ring (22) is provided with a plurality of cleaning holes (23). The frame (01) is provided with a driving mechanism for driving the moving rod (21) to move up and down. Component (4); the stirring shaft (12) is configured as a hollow structure, a liquid inlet (03) is provided at the lower end of the stirring shaft (12), a one-way spring (06) for blocking the liquid inlet (03) is provided at the lower end of the stirring shaft (12), and a liquid pumping component (3) is provided on the stirring shaft (12) for pumping the liquid in the reactor body (02) into the hollow stirring shaft (12), and the liquid pumping component (3) also pushes the liquid in the stirring shaft (12) into the cleaning ring (22) and sprays the liquid onto the inner wall of the reactor body (02) through the cleaning hole (23) on the cleaning ring (22).

2. A pharmaceutical intermediate processing reactor according to claim 1, characterized in that: The liquid pumping assembly (3) includes a bellows (31) arranged in the stirring shaft (12) and a liquid pumping rod (32) slidably connected to the stirring shaft (12), the liquid pumping rod (32) is provided with a mounting assembly (5), the liquid pumping rod (32) is fixed to the moving rod (21) through the mounting assembly (5), one end of the bellows (31) is fixed to the liquid inlet (03), and the other end is fixed to the liquid pumping rod (32), and the liquid pumping rod (32) is fixed to the moving rod (21) through the mounting assembly (5).

3. A pharmaceutical intermediate processing reactor according to claim 2, characterized in that: The cleaning ring (22) is provided with a connecting assembly (6) for connecting the cleaning ring (22) and the moving rod (21). The connecting assembly (6) comprises a connecting ring (62) fixed on the moving rod (21) and a connecting pipe (61) fixed on the connecting ring (62). The connecting ring (62) is provided with a hollow structure. One end of the connecting pipe (61) is used for communicating with the cleaning ring (22), and the other end is used for connecting with the cavity of the connecting ring (62).

4. A pharmaceutical intermediate processing reactor according to claim 3, characterized in that: The connecting pipe (61) is arranged at an angle, and the connecting ring (62) is arranged above the cleaning ring (22).

5. A pharmaceutical intermediate processing reactor according to claim 3, characterized in that: The mounting assembly (5) comprises a mounting block (51) fixed on the pumping rod (32) and a communicating hole (52) provided on the mounting block (51); the mounting block (51) is fixedly mounted on the connecting ring (62); the communicating hole (52) is used to connect the cavity of the connecting ring (62) with the chamber in the bellows (31); when the moving rod (21) drives the connecting ring (62) to move, the connecting ring (62) drives the pumping rod (32) to move and the bellows (31) to expand and contract.

6. A pharmaceutical intermediate processing reactor according to claim 5, characterized in that: The mounting block (51) is provided with an adjusting assembly (7), and the adjusting assembly (7) is used to adjust the size of the communicating hole (52). When the opening of the communicating hole (52) is the largest, the pressure of the liquid ejected from the cleaning hole (23) is the smallest. The adjusting assembly (7) includes an adjusting shaft (71) fixedly mounted on the inner wall of the communicating hole (52) and an adjusting plate (72) rotatably connected to the adjusting shaft (71). The connecting ring (62) is provided with a pushing assembly (8) for pushing the adjusting plate (72) to rotate. When the pushing assembly (8) pushes the adjusting plate (72) to rotate, the opening of the communicating hole (52) becomes smaller, the pressure of the liquid entering the connecting ring (62) becomes larger, and the pressure of the liquid ejected from the cleaning hole (23) becomes larger.

7. A pharmaceutical intermediate processing reactor according to claim 6, characterized in that: A torsion spring (73) is sleeved on the adjusting shaft (71), one end of the torsion spring (73) is fixed on the adjusting shaft (71), and the other end is fixed on the adjusting plate (72).

8. The pharmaceutical intermediate processing reactor according to claim 6, characterized in that: The pushing assembly (8) includes a limiting rod (81) slidably connected to the mounting block (51), a pushing block (82) fixed on the limiting rod (81), a pushing shaft (83) fixed on the pushing block (82), and a pushing strip (84) fixed on the inner wall of the clearance groove (04), wherein the pushing strip (84) is provided with a pushing inclined surface (85), the limiting rod (81) slides horizontally on the mounting block (51), and the sliding direction of the limiting rod (81) is perpendicular to the axis of the adjusting shaft (71), the axis of the pushing shaft (83) is arranged parallel to the axis of the adjusting shaft (71), and the pushing shaft (83) is arranged perpendicular to the limiting rod (81), and the side of the pushing shaft (83) abuts against the pushing inclined surface (85), and when the mounting block (51) and the moving rod (21) move downward, the pushing inclined surface (85) pushes the pushing shaft (83) to move toward the axis direction close to the stirring shaft (12).

9. The pharmaceutical intermediate processing reactor according to claim 1, characterized in that: The driving assembly (4) comprises a driving sleeve (41) fixed on the frame (01) and a driving rod (42) fixed on the moving rod (21); a thread groove (43) is provided on the inner wall of the driving sleeve (41), and the driving rod (42) is slidably connected in the thread groove (43).

10. The pharmaceutical intermediate processing reactor according to claim 8, characterized in that: The lower surface of the adjustment plate (72) is provided with an inclined surface (9), and the pushing block (82) is provided with an arcuate surface (91), and the arcuate surface (91) is used to abut against the inclined surface (9).

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