Intelligent fixed injection device for establishing mouse Parkinson model
By designing an intelligent fixed injection device, the problem of poor positioning of the existing device was solved, precise adjustment of the injection position and avoidance of obstruction of the surgical field were achieved, adapting to the needs of mice of different sizes and improving the convenience and accuracy of surgery.
Patent Information
- Application Number
- CN202510843079.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-23
- Publication Date
- 2025-10-10
AI Technical Summary
The existing injection device used to establish a mouse Parkinson's disease model has poor positioning effect before and after injection, requiring adjustment of component positions. The injection position is inconvenient and easily blocks the surgical field.
An intelligent fixed injection device for establishing a Parkinson's disease mouse model was designed, which includes a base, a positioning frame, and a limiting mechanism. The positioning block can be moved and the angle adjusted by engaging a horizontal slide and gears. Combined with a limiting box and a limiting pad, it can adapt to mice of different sizes and avoid obstruction of the surgical field.
The precise adjustment of the injection position is achieved to adapt to mice of different sizes, reducing the obstruction of the surgical field and improving the convenience and accuracy of the operation.
Smart Images
Figure CN120753820A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of Parkinson's model establishment equipment, and in particular to an intelligent fixed injection device for establishing a mouse Parkinson's model. Background Art
[0002] Parkinson's disease is a common chronic central nervous system degenerative disorder characterized by degeneration of the nigrostriatal pathway. It is characterized by the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, accompanied by a significant decrease in striatal DA content. Lewy bodies, formed by misfolded alpha-synuclein, are the primary pathological feature, and can affect different neurotransmitter systems and different nervous system regions. The pathogenesis of Parkinson's disease is not fully understood, and currently there are no effective drugs to cure or reverse the disease. To better understand the pathomechanism of Parkinson's disease and identify more effective therapeutics, the establishment of animal models of Parkinson's disease is crucial.
[0003] At present, the method of injecting mice is commonly used to construct Parkinson's disease animal models. However, the existing injection devices have poor positioning effects before and after injection, and often require adjustment of the positions of various components. The injection position is inconvenient to adjust, which can easily cause errors and obstacles in the establishment of the model; at the same time, it can easily block the surgical field.
[0004] Therefore, there is an urgent need for an intelligent fixed injection device for establishing a mouse Parkinson's model to solve the above-mentioned problems. Summary of the Invention
[0005] The purpose of the present invention is to provide an intelligent fixed injection device for establishing a mouse Parkinson's disease model, which is easy to use, easy to adjust, and has precise positioning, and can effectively avoid obstruction of the surgical field.
[0006] The embodiment of the present invention is achieved as follows: An embodiment of the present application provides an intelligent fixed injection device for establishing a Parkinson's disease model in mice, which includes a base, on which a positioning frame and a limiting mechanism are provided; a horizontal slide is provided on the base, in which a horizontal slider is slidably connected, and the positioning frame is provided on the horizontal slider; the positioning frame includes an arc-shaped frame, on which an arc-shaped slide is provided, on which a positioning block is provided, on which a first gear is provided, on which an arc-shaped rack is provided, and the first gear is meshed with the arc-shaped rack; and an injection assembly is provided on the positioning block.
[0007] In some embodiments of the present invention, a second gear is provided on the horizontal sliding block, a horizontal rack is provided in the horizontal sliding groove, and the second gear is meshed with the horizontal rack.
[0008] In some embodiments of the present invention, the injection assembly includes a steering seat, a steering rod is hingedly provided on the steering seat, a third gear is provided on the steering rod, and a fourth gear is provided on the steering seat.
[0009] In some embodiments of the present invention, the above-mentioned steering rod includes an outer tube and an inner tube, and one end of the outer tube and the inner tube are socketed; a driving motor is arranged in the outer tube, and the output shaft of the driving motor is provided with a driving screw, and the inner side of the inner tube is provided with a thread and is threadedly connected to the driving screw; a limiting groove is provided on the inner side of the outer tube, and a limiting protrusion adapted to the limiting groove is provided on the outer side of the inner tube; and an injection head is provided on the inner tube.
[0010] In some embodiments of the present invention, the injection head includes a shell, the shell is provided with a vertical slide groove, the vertical slide groove is slidably connected to a needle seat, and the injection needle is provided on the needle seat; an induction plate is provided between the needle seat and the shell.
[0011] In some embodiments of the present invention, the above-mentioned limiting mechanism includes a limiting box, which is provided with an opening, and limiting frames are provided on both sides of the opening, and the limiting frames are provided with two limiting pads.
[0012] In some embodiments of the present invention, two horizontal grooves are symmetrically provided on the above-mentioned limiting frame, and sliding blocks are provided on the horizontal grooves; and the limiting pads are provided on the sliding blocks.
[0013] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects: Existing injection devices have poor positioning effects before and after injection, and often require adjustment of the positions of various components. The injection position is inconvenient to adjust and easily obstructs the surgical field. The present invention provides an intelligent fixed injection device for establishing a Parkinson's disease model in mice, which includes a base, a positioning frame and a limiting mechanism provided on the base; a horizontal slide provided on the base, a horizontal slider slidably connected in the horizontal slide, and the positioning frame provided on the horizontal slider; the positioning frame includes an arc-shaped frame, an arc-shaped slide provided on the arc-shaped frame, a positioning block provided on the arc-shaped slide, a first gear provided on the positioning block, an arc-shaped rack provided on the arc-shaped slide, and the first gear meshes with the arc-shaped rack; and an injection assembly provided on the positioning block.
[0014] The present invention provides a horizontal slide groove so that the positioning frame can be moved by a horizontal slider provided on the horizontal slide groove, thereby adjusting its position relative to the mouse to be injected; a first gear is provided on the positioning block, and the first gear is engaged with the arc-shaped rack, so that the injection assembly provided on the positioning block can not only meet the needs of surgery in various positions and adapt to mice of various sizes to be injected, but also can effectively avoid obstruction of the surgical field of medical staff through adjustment, so that the surgery can be carried out more conveniently. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.
[0016] Figure 1 A front view of an embodiment of the present invention; Figure 2 A cross-sectional view of an arc-shaped frame according to an embodiment of the present invention; Figure 3 A partial cross-sectional view of a steering rod according to an embodiment of the present invention; Figure 4 A cross-sectional view of an injection head according to an embodiment of the present invention Figure 5 2 is a cross-sectional view of a limiting frame according to an embodiment of the present invention.
[0017] Icons: 1. Base; 2. Horizontal slider; 3. Arc frame; 4. Limit box; 5. Limit frame; 6. Limit pad; 7. Return spring; 8. Horizontal groove; 9. Arc slide; 10. Arc rack; 11. Positioning block; 12. First gear; 13. Steering seat; 14. Steering rod; 15. Outer tube; 16. Inner tube; 17. Drive motor; 18. Drive screw; 19. Limit groove; 20. Limit protrusion; 21. Injection head; 22. Fourth gear; 23. Third gear; 24. Housing; 25. Needle seat; 26. Induction plate. DETAILED DESCRIPTION
[0018] To make the objectives, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.
[0019] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the invention as claimed, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort shall fall within the scope of protection of the present invention.
[0020] Example: Please refer to Figure 1-5This embodiment provides an intelligent fixed injection device for establishing a mouse Parkinson's disease model, which includes a base 1, on which a positioning frame and a limiting mechanism are provided; a horizontal slide is provided on the base 1, in which a horizontal slider 2 is slidably connected, and the positioning frame is provided on the horizontal slider 2; the positioning frame includes an arc frame 3, on which an arc slide 9 is provided, on which a positioning block 11 is provided, on which a first gear 12 is provided, and on which an arc rack 10 is provided on the arc slide 9, and the first gear 12 is meshed with the arc rack 10; and an injection assembly is provided on the positioning block 11.
[0021] Existing injection devices have poor positioning effects before and after injection, and often require adjustment of the positions of various components. The injection position is inconvenient to adjust and easily blocks the surgical field. The present invention provides a horizontal slide groove so that the positioning frame can be moved by a horizontal slider 2 provided on the horizontal slide groove, thereby adjusting its position relative to the mouse to be injected; a first gear 12 is provided on the positioning block 11, and the first gear 12 engages with the arc-shaped rack 10, so that the injection assembly provided on the positioning block 11 can not only meet the needs of various surgical positions and adapt to mice of various sizes to be injected, but also can effectively avoid blocking the surgical field of medical staff through adjustment, so that the operation can be carried out more conveniently. In some embodiments of the present invention, a second gear is provided on the horizontal slider 2, and a horizontal rack is provided within the horizontal chute. The second gear meshes with the horizontal rack. Rotating the second gear allows the horizontal slider 2 to move within the horizontal chute, thereby allowing it to move forward and backward, facilitating injection and needle installation.
[0022] In some embodiments of the present invention, the injection assembly includes a steering seat 13, a steering rod 14 is hingedly provided on the steering seat 13, a third gear 23 is provided on the steering rod 14, and a fourth gear 22 is provided on the steering seat 13. The fourth gear 22 is hingedly provided on the steering seat 13 so that the injection angle can be adjusted.
[0023] In some embodiments of the present invention, the steering rod 14 includes an outer tube 15 and an inner tube 16, one end of which is sleeved together. A drive motor 17 is disposed within the outer tube 15, and a drive screw 18 is disposed on the output shaft of the drive motor 17. The inner side of the inner tube 16 is threaded and threadedly connected to the drive screw 18. A limiting groove 19 is disposed on the inner side of the outer tube 15, and a limiting protrusion 20 is disposed on the outer side of the inner tube 16, which is adapted to fit within the limiting groove 19. The inner tube 16 is also provided with an injection head 21. The rotation of the drive screw 18 allows the steering rod 14 to be extended and retracted, while simultaneously ensuring fine adjustment and stable support strength of the steering rod 14.
[0024] In some embodiments of the present invention, injection head 21 includes a housing 24, which is provided with a vertical slide groove, which is slidably connected to a needle seat 25. The injection needle is mounted on needle seat 25. An inductive patch 26 is provided between needle seat 25 and housing 24. A gap exists between needle seat 25 and housing 24. After the injection needle contacts the mouse brain, needle seat 25 moves upward to connect with inductive patch 26, confirming the injection position.
[0025] It is understandable that the first gear 12, the second gear and the third gear 23 are all provided with a driving device; the device is provided with a controller to control the driving device and the driving motor 17 and record the injection position by the number of rotations of the gears.
[0026] In some embodiments of the present invention, the limiting mechanism includes a limiting box 4, an opening is provided on the limiting box 4, and limiting frames 5 are provided on both sides of the opening, and two limiting pads 6 are provided on the limiting frame 5. Two horizontal grooves 8 are symmetrically provided on the limiting frame 5, and a sliding block is provided on the horizontal groove 8; the limiting pad 6 is provided on the sliding block. The opening and the limiting frame 5 provided on the limiting box 4 are convenient for placing and limiting the mouse head; the setting of the sliding block can be adjusted to adapt to mice of various sizes, and the positioning structure of the device is more adaptable. It can be understood that the limiting pad 6 clamps and limits the two sides of the mouse's injection site. A reset spring 7 is provided between the sliding block and the horizontal groove 8 to limit the mouse.
[0027] In summary, an embodiment of the present invention provides an intelligent fixed injection device for establishing a mouse Parkinson's model, which includes a base 1, on which a positioning frame and a limiting mechanism are provided; a horizontal slide is provided on the base 1, in which a horizontal slider 2 is slidably connected, and the positioning frame is provided on the horizontal slider 2; the positioning frame includes an arcuate frame 3, on which an arcuate slide 9 is provided, on which a positioning block 11 is provided, on which a first gear 12 is provided, on which an arcuate rack 10 is provided, and the first gear 12 is meshed with the arcuate rack 10; and an injection assembly is provided on the positioning block 11. The present invention provides a horizontal slide groove so that the positioning frame can be moved by a horizontal slider 2 provided on the horizontal slide groove, thereby adjusting its position relative to the mouse to be injected; a first gear 12 is provided on the positioning block 11, and the first gear 12 is engaged with the arc-shaped rack 10, so that the injection assembly provided on the positioning block 11 can not only meet the needs of surgery in various positions and adapt to mice of various sizes to be injected, but also can effectively avoid obstruction of the surgical field of medical staff through adjustment, so that the operation can be carried out more conveniently.
[0028] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Those skilled in the art will readily appreciate that various modifications and variations of the present invention are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.
Claims
1. An intelligent fixed injection device for establishing a mouse Parkinson's disease model, characterized in that: It includes a base, on which a positioning frame and a limiting mechanism are provided; a horizontal slide is provided on the base, a horizontal slider is slidably connected in the horizontal slide, and the positioning frame is provided on the horizontal slider; the positioning frame includes an arc-shaped frame, an arc-shaped slide is provided on the arc-shaped frame, a positioning block is provided on the arc-shaped slide, a first gear is provided on the positioning block, an arc-shaped rack is provided on the arc-shaped slide, and the first gear is engaged with the arc-shaped rack; an injection assembly is provided on the positioning block.
2. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 1, characterized in that: A second gear is provided on the horizontal sliding block, a horizontal rack is provided in the horizontal sliding groove, and the second gear is meshed with the horizontal rack.
3. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 2, characterized in that: The injection assembly includes a steering seat, a steering rod is hingedly provided on the steering seat, a third gear is provided on the steering rod, and a fourth gear is provided on the steering seat.
4. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 3, characterized in that: The steering rod includes an outer tube and an inner tube, and one end of the outer tube and the inner tube are socketed; a driving motor is provided in the outer tube, and the output shaft of the driving motor is provided with a driving screw, and the inner side of the inner tube is provided with a thread and is threadedly connected to the driving screw; a limiting groove is provided on the inner side of the outer tube, and a limiting protrusion adapted to the limiting groove is provided on the outer side of the inner tube; and an injection head is provided on the inner tube.
5. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 4, characterized in that: The injection head includes a shell, the shell is provided with a vertical slide groove, the vertical slide groove is slidably connected to a needle seat, and the injection needle is arranged on the needle seat; an induction plate is provided between the needle seat and the shell.
6. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 5, characterized in that: The limiting mechanism comprises a limiting box, an opening is provided on the limiting box, limiting frames are provided on both sides of the opening, and two limiting pads are provided on the limiting frames.
7. The intelligent fixed injection device for establishing a mouse Parkinson's disease model according to claim 6, characterized in that: Two horizontal grooves are symmetrically arranged on the limiting frame, and sliding blocks are arranged on the horizontal grooves; and the limiting pad is arranged on the sliding blocks.