Traditional Chinese medicine shampoo composition with effects of growing and consolidating hair, removing dandruff and relieving itching and preparation method of traditional Chinese medicine shampoo composition

Abstract

The invention relates to the technical field of daily chemical products, in particular to a traditional Chinese medicine shampoo composition with hair growing, hair strengthening, dandruff removing and itching relieving functions and a preparation method, the traditional Chinese medicine shampoo composition comprises a hair growing and hair strengthening group: 12-16% of cacumen biotae, 9-13% of radix polygoni multiflori preparata, 3-5% of fructus ligustri lucidi, 3-5% of rhizoma drynariae, 3-5% of radix angelicae sinensis and 3-5% of radix ginseng (the total amount is 38 + / -2%); the anti-dandruff and anti-inflammation group comprises 5-9% of fructus kochiae, 4-7% of radix stemonae, 3-5% of radix scutellariae and 3-5 The itching relieving and relieving group comprises 5-9% of saponin, 3-5% of mint, 4-6% of ligusticum sinense oliver and 3-5% of garden balsam stem; the carrier synergistic group comprises 4-8% of Chinese soapberry fruit, 1-3% of duckweed, 2-4% of mulberry leaf and 2-4% of herba andrographitis, a four-stage effect model of cleaning, permeation, treatment and repair is established, redundant grease and dirt on the scalp are thoroughly removed in the cleaning stage, active ingredients are promoted to penetrate into hair follicles in the permeation stage, accurate repair is performed in the treatment stage aiming at the hair growth disorder and dandruff removal problems, and the effect of removing dandruff is achieved. In the repairing stage, the scalp barrier is strengthened, and long-term health is maintained.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, in particular to a traditional Chinese medicine shampoo composition having the functions of promoting hair growth, strengthening hair, removing dandruff and relieving itching, and a preparation method thereof. Background Art

[0002] CN113476474A specifically discloses a drug for improving bone quality based on niacinamide and vitamin K2, and its preparation method. The drug comprises a composition containing niacinamide and vitamin K2, wherein the active ingredients of the composition include niacinamide (NAM), vitamin K2, vitamin D3, magnesium (Mg), calcium (Ca), zinc (Zn), and selenium (Se). The present invention provides a drug for improving bone quality based on niacinamide and vitamin K2, and its preparation method, which can be used in anti-aging, osteoporosis, and muscle spasm prevention and treatment drugs and / or health products.

[0003] Although existing technologies such as CN113476474A disclose a combination of Platycladus orientalis leaves and Polygonum multiflorum, they do not solve the antagonism between hair growth / anti-dandruff components (the precipitation rate of Stemona alkaloids and Platycladus orientalis leaf flavonoids is >40%), and the content of processed Polygonum multiflorum is less than 9% (hair density is only 15%), resulting in some effects not being achieved.

[0004] Long-term use of chemical synthetic shampoos can easily lead to scalp irritation and hair follicle damage; because the chemicals such as sulfates and parabens contained in them can destroy the scalp's natural protective barrier, causing inflammatory reactions and itching, which over time may cause irreversible damage such as hair follicle atrophy and increased hair loss.

[0005] Single-function products cannot solve complex problems such as hair loss, dandruff, and itching at the same time; for example, shampoos that focus on anti-hair loss often lack effective ingredients to inhibit dandruff fungi or relieve itching, and products targeting dandruff may ignore the root cause of hair loss, which makes it difficult for users to comprehensively improve multi-dimensional scalp health problems during use.

[0006] Because active molecules in plant extracts are easily degraded or lost during processing and storage, and there is a lack of scientific ratios and synergistic mechanisms between different plant ingredients, the overall hair care effect is not significant, and it is unable to effectively address multiple challenges such as hair loss and dandruff. Therefore, natural plant ingredient shampoos generally have problems such as low active ingredient concentration and poor synergistic effects. Moreover, although Platycladus orientalis leaves and Polygonum multiflorum have hair growth effects, their transdermal absorption rate is low, and there is a risk of incompatibility between anti-dandruff ingredients (such as Stemona radix and Sophora flavescens) and hair growth ingredients. Summary of the Invention

[0007] The purpose of the present invention is to provide a traditional Chinese medicine shampoo composition with the effects of hair growth, hair strengthening, dandruff removal and itching relief, and a preparation method thereof.

[0008] In order to achieve the above object, the present application adopts the following technical solutions: The Chinese medicine shampoo composition with the multiple effects of hair growth, hair fixing, dandruff removing and itching relieving comprises the following components in percentage by weight: The hair growth and fixing group: Platycladi Cacumen 12-16%, Radix Polygoni Multiflori Praeparata 9-13%, Ligustri Lucidi Fructus 3-5%, Drynariae Rhizoma 3-5%, Angelicae Sinensis Radix 3-5%, Radix Ginseng 3-5% (total amount 38±2%); The dandruff removing and inflammation relieving group: Fructus Kochiae 5-9%, Radix Stachyri 4-7%, Radix Scutellariae 3-5%, Radix Sophorae 3-5%; The itching relieving and soothing group: Gleditsiae Radix 5-9%, Herba Mentholis 3-5%, Artemisiae Argyi Folium 4-6%, Herba Lysimachiae 3-5%; The carrier synergistic group: Sapindus 4-8%, Lemna 1-3%, Folium Mori 2-4%, Galeopsis 2-4%.

[0009] Preferably, the mass ratio of Platycladi Cacumen to Radix Polygoni Multiflori Praeparata is (1.2-1.5):1.

[0010] Preferably, the phospholipid liposome encapsulating the active ingredients has a particle size of 100-200 nm.

[0011] Preferably, the Radix Polygoni Multiflori Praeparata is treated by black bean juice steaming, the free anthraquinones are ≤0.1 ppm, and the stilbene glucosides are ≥5.0%.

[0012] Preferably, the active ingredients are loaded on the nanoliposome, the particle size is 100-200 nm, and the encapsulation rate is ≥90%.

[0013] Preferably, the pH value is 5.5-6.5, and the Lemna polysaccharide 0.1-0.3% is used as an ionic stabilizer.

[0014] Preferably, the preparation method of the Chinese medicine shampoo composition with the multiple effects of hair growth, hair fixing, dandruff removing and itching relieving comprises the following steps: a) supercritical CO2 extraction of the fat-soluble components; b) microwave extraction of the water-soluble components; c) preparation of Platycladi Cacumen flavones and Radix Polygoni Multiflori Praeparata stilbene glucosides into phospholipid liposomes; d) mixing of all components under inert gas at less than 45°C.

[0015] Preferably, in the preparation method of the Chinese medicine shampoo composition with the multiple effects of hair growth, hair fixing, dandruff removing and itching relieving, the extraction conditions in step a are 30-40 MPa and 40-50°C.

[0016] Preferably, in the preparation method of the Chinese medicine shampoo composition with the multiple effects of hair growth, hair fixing, dandruff removing and itching relieving, the microwave extraction power is 600-1000 W, and the temperature is 50-70°C.

[0017] The present invention has at least the following beneficial effects: Through the ion balance regulation mechanism of duckweed and mulberry leaf extracts, the antagonism between hair growth ingredients and anti-dandruff ingredients is effectively eliminated, ensuring that the two work together to promote hair follicle vitality and inhibit dandruff formation; Establish a four-step action model of "cleansing-penetration-treatment-repair". The cleansing stage thoroughly removes excess oil and dirt from the scalp. The penetration stage promotes the penetration of active ingredients into hair follicles. The treatment stage precisely repairs hair growth disorders and dandruff problems. The repair stage strengthens the scalp barrier and maintains long-term health. By optimizing formulation technology and safety assessment, pharmaceutical-grade doses such as Stemona extract (content ≥5%) are safely introduced into the daily chemical product system, ensuring efficient therapeutic effects while avoiding potential irritation or adverse reactions.

[0018] This design found that when Artemisia annua extract (5.4%) and peppermint extract (4%) were used in combination, their synergistic inhibition of IL-31, a key mediator of itching, was significantly improved compared to the use of either ingredient alone. ELISA testing confirmed that the inhibition efficiency was increased by 3.2 times.

[0019] Breaking through the antagonistic limitations between traditional hair growth and anti-dandruff active ingredients: Experiments have confirmed that when the total concentration of Stemona japonica or Kochia scoparia fruit extracts in the formula is greater than 12%, and the concentration of Platycladus orientalis leaf extract exceeds 10%, not only does it overcome the mutual inhibition between the ingredients, but the in vitro proliferation rate of hair follicle cells is actually increased by 18.7% compared with the control group. This result was verified by CCK-8 cell activity detection.

[0020] The "critical efficacy threshold" theoretical model was proposed and verified: for the core ingredient, processed Polygonum multiflorum, the study found that when its concentration was lower than 9%, the hair growth efficacy would drop sharply to a level significantly lower than the effective level; through dose-effect curve analysis, the median effective dose (ED50) was accurately determined. 50 ) is 8.7%, which is the core protection boundary established by the present invention and the key basis for formula optimization. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0022] Figure 1 is a flow chart of the present invention; Figure 2 Schematic diagram of nano-targeted delivery in Example 2. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. Example 1

[0024] Reference Figure 1 The Chinese medicinal shampoo composition has multiple effects of hair growth, hair strengthening, dandruff removal and itching relief, including: Hair growth and strengthening group: Platycladus orientalis leaves 12%-16%, processed Polygonum multiflorum 9%-13%, Ligustrum lucidum fruit 3%-5%, Drynaria fortunei 3%-5%, Chinese angelica 3%-5%, ginseng 3%-5% (total 38±2%); Anti-dandruff and anti-inflammatory group: Kochia scoparia 5%-9%, Stemona 4%-7%, Scutellaria baicalensis 3%-5%, Sophora flavescens 3%-5% (total 20±2%); Antipruritic and soothing group: 5%-9% of sapodilla, 3%-5% of mint, 4%-6% of artemisia, 3%-5% of radix polygoni multiflori (total amount 14.4±2%); Carrier enhancement group: Sapindus mukorossi 4%-8%, Duckweed 1%-3%, Mulberry leaf 2%-4%, Herba Dioscoreae 2%-4%.

[0025] The mass ratio of Platycladus orientalis leaves to processed Polygonum multiflorum is (1.2-1.5):1.

[0026] The particle size of the phospholipids encapsulating the active ingredients is 100-200 nm.

[0027] Preparation method of a Chinese medicinal shampoo composition with multiple functions of hair growth, hair strengthening, dandruff removal and itching relief: Segment extraction Fat-soluble components (angelica, ginseng) → supercritical CO2 extraction (35MPa, 45℃); Water-soluble components (Gleditsia sinensis, Sapindus mukorossi) → Microwave-assisted extraction (800W, 60℃); Nano-encapsulation enhancement Platycladus orientalis leaf flavonoids and Polygonum multiflorum stilbene glycosides were loaded into phospholipids (particle size ≤ 200 nm), with an encapsulation efficiency of ≥ 92%; Low temperature mixing All extracts were mixed below 40°C to avoid inactivation of heat-sensitive components.

[0028] 1. Hair growth and hair strengthening core group (total 38%): - Platycladus orientalis leaves (14%), processed Polygonum multiflorum (11%), Ligustrum lucidum fruit (4%), Drynaria rhizome (4%), Angelica sinensis (4%), and Panax ginseng (4%) → activate hair follicle stem cells and upregulate the expression of FGF-7 growth factor.

[0029] 2. Anti-dandruff and anti-inflammatory group (total 20%): - Kochia scoparia (7%), Stemona tuberosa (5.6%), Scutellaria baicalensis (4%), Sophora flavescens (4%); →Inhibits Malassezia activity (MIC≤0.5mg / mL).

[0030] 3. Antipruritic and soothing group (total 14.4%): - Gleditsia sinensis (7%), mint (4%), artemisia annua (5.4%), and radix scutellariae (4%); → Blocks TRPV1 itch receptor channel.

[0031] 4. Carrier enhancement group: - Soapberry (6%) is a natural surfactant; - Duckweed (2%), mulberry leaves (3%), and sweat lotus (3%) enhance the penetration of ingredients.

[0032] The product obtained through the above steps was tested and the following data was obtained: Efficacy indicators The present invention Commercially available Chinese herbal shampoo P-value New hair density 、38.7% 、12.3% <0.001 Breaking strength 、52.1% 、18.9% <0.01 Dandruff reduction rate 89.2% 67.5% <0.05 Duration of itching relief 8.5h 3.2h <0.001 Example 2

[0033] Reference Figure 2 The Chinese medicinal shampoo composition has multiple effects of hair growth, hair strengthening, dandruff removal and itching relief, including: Hair growth and strengthening group: Platycladus orientalis leaves 12%-16%, processed Polygonum multiflorum 9%-13%, Ligustrum lucidum fruit 3%-5%, Drynaria fortunei 3%-5%, Chinese angelica 3%-5%, ginseng 3%-5% (total 38±2%); Anti-dandruff and anti-inflammatory group: Kochia scoparia 5%-9%, Stemona 4%-7%, Scutellaria baicalensis 3%-5%, Sophora flavescens 3%-5% (total 20±2%); Antipruritic and soothing group: 5%-9% of sapodilla, 3%-5% of mint, 4%-6% of artemisia, 3%-5% of radix polygoni multiflori (total amount 14.4±2%); Carrier enhancement group: Sapindus mukorossi 4%-8%, Duckweed 1%-3%, Mulberry leaf 2%-4%, Herba Dioscoreae 2%-4%.

[0034] The processed Polygonum multiflorum is steamed with black bean juice, with free anthraquinone ≤ 0.1ppm and diphenyl glycoside ≥ 5.0%.

[0035] The active ingredients are loaded in nanoliposomes with a particle size of 100-200nm and an encapsulation efficiency of ≥90%.

[0036] The pH value is 5.5-6.5, and it contains 0.1% to 0.3% duckweed polysaccharide as an ion stabilizer.

[0037] A method for preparing a traditional Chinese medicine shampoo composition having multiple functions of hair growth, hair strengthening, dandruff removal and itching relief comprises the following steps: a) Supercritical CO2 extraction of fat-soluble components; b) microwave extraction of water-soluble components; c) preparing phospholipids from Platycladus orientalis leaf flavonoids and Polygonum multiflorum stilbene glycosides; d) All components were mixed under inert gas at a temperature below 45°C.

[0038] The extraction conditions in step a are 30-40 MPa and 40-50° C.

[0039] The power of microwave extraction is 600-1000W and the temperature is 50-70℃.

[0040] Components Dosage (g / 100g) Preprocessing method Processed Polygonum multiflorum 11 Black bean juice steamed for 48 hours Platycladus orientalis leaves 14 Supercritical CO2 extraction Baibu 5.6 70% ethanol reflux extraction Mint 4 Steam distillation of essential oils Specifically, the preparation is carried out by the following process: 1. Extract the fat-soluble components (angelica, ginseng, and drynaria) with supercritical CO2 (conditions: 35MPa / 45℃ / 2h) to obtain oleoresin; 2. The water-soluble components (Gleditsia sinensis, Sapindus mukorossi, Kochia scoparia) were extracted using microwave (800W / 60℃ / 30min) and concentrated to a specific gravity of 1.2; 3. Prepare nanoliposomes by combining Platycladus orientalis leaf flavonoids, Polygonum multiflorum stilbene glycosides and phospholipids (mass ratio 1:4); 4. All components were mixed at 40°C under nitrogen protection, and Herba Dioscoreae Polysaccharides were added for thickening.

[0041] Conduct experiments to obtain key data: 1. Comparison of transdermal absorption Element Conventional extracts Nanoliposomes Increase multiple Platycladus orientalis leaf flavonoids 7.8μg / cm² 28.4μg / cm² 3.6× Stilbene glycosides 5.2μg / cm² 19.7μg / cm² 3.8× 2. Irritation test (OECD439) sample Cell survival rate% score The present invention 98.3±2.1 0.1 A hair growth shampoo 74.5±3.8 2.3 3. Clinical efficacy (60 patients with androgenic alopecia) index 28 days 56 days Hair density 、25.7%* 、38.9%** Dandruff area -68.2%* -89.4%** Itch score 2.1→0.7* 2.1→0.3** The edited text is as follows: Traditional Chinese medicine shampoo faces three major technical bottlenecks: ① Natural surfactants such as saponins and soapberries are prone to precipitation with active ingredients (e.g., Stemona alkaloids precipitate when pH>7); ② The anthraquinone components of Polygonum multiflorum are prone to irritating the scalp (the sensitization rate reported in the literature is ≥6.3%); ③The transdermal rate of hair growth components (such as Platycladus orientalis leaf flavonoids) is only <8%.

[0042] Compared with the prior art, this embodiment is unpredictable: It was found that the synergistic effect of Artemisia selengensis (5.4%) and mint (4%) can significantly enhance the inhibitory effect on the itch mediator IL-31, with the inhibition efficiency increased by 3.2 times (ELISA test).

[0043] Successfully broke through the antagonistic limitations of hair growth and anti-dandruff ingredients: when the total amount of Stemona japonica / Kochia scoparia fruit combination is greater than 12% and the Platycladus orientalis leaf content is greater than 10%, the proliferation rate of hair follicle cells increased by 18.7% against the trend (CCK-8 experiment).

[0044] Establishing the “critical efficacy threshold”: When the content of processed Polygonum multiflorum is less than 9%, its hair growth effect decreases drastically (ED 50 =8.7%).

[0045] The above shows and describes the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions merely illustrate the principles of the present invention. Various changes and modifications may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and modifications are intended to fall within the scope of the present invention. The scope of protection claimed by the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicinal shampoo composition having multiple effects of hair growth and strengthening, dandruff removal and itching relief, characterized in that: Contains the following components in weight percentage: Hair growth and strengthening group: Platycladus orientalis leaves 12%-16%, processed Polygonum multiflorum 9%-13%, Ligustrum lucidum fruit 3%-5%, Drynaria fortunei 3%-5%, Chinese angelica 3%-5%, ginseng 3%-5% (total 38±2%); Anti-dandruff and anti-inflammatory group: Kochia scoparia 5%-9%, Stemona 4%-7%, Scutellaria baicalensis 3%-5%, Sophora flavescens 3%-5%; Antipruritic and soothing group: 5% to 9% of soapberry, 3% to 5% of peppermint, 4% to 6% of artemisia, and 3% to 5% of radix polygoni multiflori; Carrier enhancement group: Sapindus mukorossi 4%-8%, Duckweed 1%-3%, Mulberry leaf 2%-4%, Herba Dioscoreae 2%-4%.

2. The Chinese medicinal shampoo composition having the effects of hair growth, hair strengthening, dandruff removal and itching relief according to claim 1 and its preparation method, characterized in that: The mass ratio of Platycladus orientalis leaves to processed Polygonum multiflorum is (1.2-1.5):

1.

3. The Chinese medicinal shampoo composition having the effects of hair growth, hair strengthening, dandruff removal and itching relief and its preparation method according to claim 1, characterized in that: The particle size of the phospholipids encapsulating the active ingredients is 100-200 nm.

4. The Chinese medicinal shampoo composition having the effects of hair growth and strengthening, removing dandruff and relieving itching and the preparation method thereof according to claim 1, characterized in that: The processed Polygonum multiflorum is steamed with black bean juice, with free anthraquinone ≤ 0.1ppm and diphenyl glycoside ≥ 5.0%.

5. The Chinese medicinal shampoo composition having the effects of hair growth, hair strengthening, dandruff removal and itching relief and its preparation method according to claim 1, characterized in that: The active ingredients are loaded in nanoliposomes with a particle size of 100-200nm and an encapsulation efficiency of ≥90%.

6. The Chinese medicinal shampoo composition having the effects of hair growth and strengthening, removing dandruff and relieving itching and its preparation method according to claim 1, characterized in that: The pH value is 5.5-6.5, and it contains 0.1% to 0.3% duckweed polysaccharide as an ion stabilizer.

7. The method for preparing the Chinese medicinal shampoo composition having multiple functions of hair growth and strengthening, dandruff removal and itching relief according to any one of claims 1 to 6, characterized in that: The steps include: a) Supercritical CO2 extraction of fat-soluble components; b) microwave extraction of water-soluble components; c) preparing phospholipids from Platycladus orientalis leaf flavonoids and Polygonum multiflorum stilbene glycosides; d) All components were mixed under inert gas at a temperature below 45°C.

8. The method for preparing the Chinese medicinal shampoo composition having multiple functions of hair growth and strengthening, dandruff removal and itching relief according to claim 7, characterized in that: The extraction conditions in step a are 30-40 MPa and 40-50° C.

9. The method for preparing the Chinese medicinal shampoo composition having multiple functions of hair growth and strengthening, and anti-dandruff and antipruritic according to claim 7, characterized in that: The power of microwave extraction is 600-1000W and the temperature is 50-70℃.

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