An indwelling needle for transcranial Doppler ultrasound imaging

Abstract

This invention relates to an indwelling needle for transcranial Doppler ultrasound imaging, belonging to the field of medical device technology. It solves the problems of existing three-way infusion connectors with rotary valves, which suffer from incomplete closure leading to crossflow and difficulty in achieving the accurate closure position. This invention includes an injection unit, a mixing unit, a control valve unit, a first mixing chamber unit, and a second mixing chamber unit. The control valve unit switches the preparation and delivery path of the bubble contrast agent. The first and second mixing chamber units work in conjunction with the first syringe to prepare and store the bubble contrast agent. Unlike existing technologies where the user holds the first and second syringes with both hands, pushing them against each other to mix the aspirated blood with saline and air to prepare the bubble contrast agent, this invention only requires one hand, facilitating the preparation of the bubble contrast agent.

Description

[0001] This application is a divisional application of application number 202411673748.8, filed on November 21, 2024, entitled "An indwelling needle for transcranial Doppler ultrasound imaging". Technical Field

[0002] This invention relates to the field of medical device technology, specifically to an indwelling needle for transcranial Doppler ultrasound imaging. Background Technology

[0003] With the fast pace of life and changes in lifestyle, the incidence of cerebrovascular diseases is increasing year by year and is showing a tendency to affect younger people. In order to avoid the impact of cerebrovascular diseases on health, how can we achieve early diagnosis and early treatment? Transcranial Doppler ultrasound is an indispensable and important detection method.

[0004] Transcranial Doppler ultrasound is an examination method that uses the Doppler effect of ultrasound to detect the hemodynamics and physiological parameters of the major intracranial arteries, thereby assisting in the diagnosis of whether there is stenosis, occlusion or spasm of intracranial arteries, as well as the location and extent of the lesion. It has brought good news to patients with unexplained stroke, migraine, and those who need cerebrovascular monitoring.

[0005] During a special transcranial Doppler ultrasound (TCD) examination—the bubble test—dual-channel, multi-depth TCD technology is employed. The head is fixed in place, and bilateral middle cerebral arteries are probed (for patients with poor temporal window ultrasound, the vertebral arteries can be probed through the occipital or paraoccipital window). A puncture is performed in the right cubital vein. During calm breathing and the standard Valsalva maneuver, activating saline is rapidly injected, and embolic signals are monitored. Finally, the embolic signals are quantified and graded, and a report is generated. The purpose is to examine for right-to-left shunts in the heart, aiding in the diagnosis of conditions such as patent foramen ovale, and serving as a screening diagnostic basis for conditions such as unexplained migraines and stroke.

[0006] Current methods for activating saline solution involve implanting an indwelling needle, attaching a three-way infusion connector to the needle, and connecting syringes to both ends of the connector. One syringe contains saline solution, while the other contains an air syringe. The syringe with saline solution is first connected to the indwelling needle, and blood is drawn back from the needle and mixed with the saline solution in the syringe. Then, one end of the indwelling needle is closed, connecting the two syringes. The syringes push against each other, mixing the drawn-back blood with the saline solution and air to prepare a bubble contrast agent. This bubble contrast agent is then injected into the body, and the images are observed using instruments to complete the experiment.

[0007] The existing three-way infusion connector used in the experiment has a rotary valve, which controls the opening and closing of different ends by rotating the valve. However, this type of three-way connector relies solely on friction to limit the valve after rotation, which can easily lead to the valve not closing tightly and causing crossflow. Furthermore, the rotation control makes it difficult to rotate to the accurate closing position, resulting in the valve not closing tightly. In addition, the connection between the needle body and the three-way infusion connector also increases the number of steps in the experiment.

[0008] Therefore, we propose an indwelling needle for transcranial Doppler ultrasound imaging. Summary of the Invention

[0009] To address the aforementioned shortcomings of existing technologies, this invention provides an indwelling needle for transcranial Doppler ultrasound imaging. It solves the problems of existing three-way infusion connectors with rotary valves, which suffer from incomplete valve closure leading to crossflow, and the inability to accurately rotate the valve to the correct closing position, resulting in a loose valve seal.

[0010] To achieve the above-mentioned objectives, the technical solution adopted by this invention is as follows:

[0011] An indwelling needle for transcranial Doppler ultrasound imaging includes an injection unit, a mixing unit, and a control valve unit. The injection unit is connected to the mixing unit, and the control valve unit is disposed within the mixing unit. The mixing unit is used to prepare a bubble contrast agent and inject it into the human body through the injection unit. The control valve unit is used to switch the preparation and delivery path of the bubble contrast agent.

[0012] Furthermore, the injection unit includes an indwelling needle body and a fluid inlet tube. The indwelling needle body is connected to the mixing unit through the fluid inlet tube. The bubble imaging agent prepared by the mixing unit is delivered to the indwelling needle body through the fluid inlet tube and then injected into the human body.

[0013] Furthermore, the mixing unit includes a housing, a first interface, and a second interface, which are disposed opposite to each other on both sides of the housing. One end of the housing is connected to a liquid-passing tube, which is the liquid-passing end. The housing includes a hollow portion. The first interface is used to connect to a first syringe, and the second interface is used to connect to a second syringe. The liquids of the first syringe and the second syringe can be exchanged through the mixing unit to prepare a bubble developer.

[0014] Furthermore, the control valve unit includes a valve body and a first liquid transmission hole. The valve body is disposed in the hollow part of the housing, and the first liquid transmission hole is disposed on the valve body. The first liquid transmission hole is used to connect the first interface and the second interface, so that the bubble developer can flow between the first interface and the second interface.

[0015] Furthermore, the end of the valve body near the liquid inlet pipe is a liquid guiding section, which is a wedge-shaped liquid guiding section.

[0016] Furthermore, the surface of the liquid guiding section is a concave arc surface.

[0017] Furthermore, the mixing unit also includes a limiting protrusion disposed on the inner wall of the housing.

[0018] Furthermore, the control valve unit also includes a first limiting groove, a second limiting groove, and a third limiting groove, which are arranged sequentially along the axial direction of the valve body and are all circumferentially formed on the outer wall surface of the valve body; the limiting protrusion can be connected to the first limiting groove, the second limiting groove, or the third limiting groove respectively.

[0019] Furthermore, it also includes a first push-pull unit, which includes a force-applying plate, a reaction cross plate, and a reaction side plate. The force-applying plate is connected to the valve body and is a rectangular force-applying plate. There are two reaction side plates, which are respectively set at both ends in the width direction of the force-applying plate. The reaction cross plate is set parallel to the force-applying plate at the top of the reaction side plate.

[0020] Furthermore, the outer wall of the housing is a square cylindrical outer wall, and one end of the reaction cross plate can be connected to the outer wall of the housing, thereby preventing the valve body from rotating circumferentially.

[0021] Furthermore, a reinforcing rod is provided between the reaction side plate and the reaction cross plate. One end of the reinforcing rod is connected to the reaction side plate, and the other end of the reinforcing rod is connected to the reaction cross plate. The reinforcing rod is used to strengthen the connection between the reaction side plate and the reaction cross plate and prevent the reaction cross plate from rotating around the end of the reaction side plate, which would cause operational failure.

[0022] Furthermore, the mixing unit also includes a chute, which is disposed on the inner wall of one end of the housing.

[0023] Furthermore, it also includes a second push-pull unit, which includes a driving member, a connecting rod, and a rotating shaft. One end of the connecting rod is connected to the valve body, and the other end of the connecting rod is rotatably connected to the rotating shaft. The rotating shaft is fixedly connected to the driving member, and the driving member can rotate around the rotating shaft. The end of the rotating shaft is set in a slide groove, and the driving member can slide along the slide groove.

[0024] Furthermore, the mixing unit also includes a rack, which is disposed on the inner wall of the housing.

[0025] Furthermore, the driving component is a hand gear, which includes driving teeth that can connect with a rack.

[0026] An indwelling needle for transcranial Doppler ultrasound imaging includes an injection unit, a mixing unit, a control valve unit, a first mixing chamber unit, and a second mixing chamber unit. The injection unit, the first mixing chamber unit, and the second mixing chamber unit are respectively connected to the mixing unit. The control valve unit is disposed within the mixing unit. The mixing unit is used to prepare a bubble contrast agent and inject it into the human body through the injection unit. The control valve unit is used to switch the preparation and delivery path of the bubble contrast agent. The first mixing chamber unit and the second mixing chamber unit are respectively used to work together with a first syringe to prepare and store the bubble contrast agent.

[0027] Furthermore, the injection unit includes an indwelling needle body and a fluid inlet tube. The indwelling needle body is connected to the mixing unit through the fluid inlet tube. The bubble imaging agent prepared by the mixing unit is delivered to the indwelling needle body through the fluid inlet tube and then injected into the human body.

[0028] Furthermore, the mixing unit includes a housing, a first interface, and a second interface. The first interface and the second interface are disposed opposite each other on both sides of the housing. One end of the housing is connected to a liquid-passing tube, which is the liquid-passing end. The housing includes a hollow portion. The first interface is used to connect to a first syringe, and the second interface is used to connect to a second syringe. The liquids of the first syringe and the second syringe can be exchanged through the mixing unit to prepare a bubble developer.

[0029] Furthermore, the control valve unit includes a valve body and a first liquid transmission hole. The valve body is disposed in the hollow part of the housing, and the first liquid transmission hole is disposed on the valve body. The first liquid transmission hole is used to connect the first interface and the second interface, so that the bubble developer can flow between the first interface and the second interface.

[0030] Furthermore, the end of the valve body near the liquid inlet pipe is a liquid guiding section, which is a wedge-shaped liquid guiding section. The liquid guiding section can block the second interface and connect the first interface to the liquid inlet pipe.

[0031] Furthermore, the mixing unit also includes a limiting protrusion disposed on the inner wall of the housing.

[0032] Furthermore, the control valve unit also includes a first limiting groove, a second limiting groove, and a third limiting groove. The first limiting groove, the second limiting groove, and the third limiting groove are arranged sequentially along the axial direction of the valve body and are all circumferentially formed on the outer wall surface of the valve body. The limiting protrusion can be connected to the first limiting groove, the second limiting groove, or the third limiting groove, respectively.

[0033] Furthermore, the first mixing chamber unit includes a first cylinder, a first piston, and a first spring. One end of the first cylinder is connected to the second interface, and the other end of the first cylinder is a free end. The first piston and the first spring are both disposed in the hollow part of the first cylinder. One end of the first spring is connected to the first piston, and the other end of the first spring is connected to the free end of the first cylinder. The first spring is used to push the first piston towards the second interface, and the first piston is used to push the bubble developer in the hollow part of the first cylinder out of the first cylinder, thereby allowing the bubble developer to return to the first syringe.

[0034] Furthermore, the first mixing chamber unit also includes a first vent hole, which is disposed on the free end of the first cylinder. The first vent hole is used to balance the air pressure inside the first cylinder when introducing and exporting bubble developer in the first cylinder.

[0035] Furthermore, the hybrid unit also includes a third interface, which is disposed on the housing.

[0036] Furthermore, it also includes a second mixing chamber unit, the structure of which is the same as that of the first mixing chamber unit; the second mixing chamber unit includes a second cylinder, a second piston, a second spring, and a second vent hole, and the second cylinder is connected to a third interface; the second mixing chamber unit is used to work together with the first syringe to prepare and store bubble developer.

[0037] Furthermore, the control valve unit also includes a second liquid transmission port, which is disposed on the valve body. The second liquid transmission port is used to connect the first interface and the third interface, so that the bubble developer can flow between the first interface and the third interface. After the user prepares the bubble developer using the first syringe and the first mixing chamber unit, the first batch of bubble developer is stored in the first mixing chamber unit, and the second batch of bubble developer is stored in the second mixing chamber unit for later use. Bubble developer that can be used twice is prepared at once, which greatly saves preparation time.

[0038] Furthermore, the control valve unit also includes a fourth limiting groove, which is disposed on the valve body and has the same shape as the first limiting groove; the fourth limiting groove and the limiting protrusion engage, and the two ends of the second liquid transmission hole are respectively connected to the first interface and the third interface.

[0039] Compared with the prior art, the present invention can achieve at least one of the following beneficial effects:

[0040] (1) The indwelling needle of the present invention fixes the mixing unit to the injection unit, avoiding the on-site connection steps between the mixing unit and the injection unit during the operation; the valve body is slidably placed in the mixing unit, and the sealing of each end of the mixing unit is achieved by sliding the valve body, and the limit of each sealing stage is achieved by controlling the valve unit. Compared with the existing rotary three-way infusion connector, the limit is achieved by controlling the valve unit, the perception is clearer, and the valve sealing is more stable and crossflow will not occur.

[0041] (2) By setting the limiting groove and the limiting protrusion of the present invention, each limiting groove and the limiting protrusion corresponds to a closed state, and the control valve unit can play a limiting role while also playing a sealing role.

[0042] (3) The hollow part of the shell of the present invention is a cylindrical hollow part, and the outer wall of the shell is a square cylindrical outer wall. One end of the reaction cross plate can be connected to the outer wall of the shell, thereby preventing the valve body from rotating circumferentially, ensuring that the liquid guiding section can block the second interface, and avoiding the situation where the hollow part is not tightly sealed and crossflow occurs due to the deflection of the liquid guiding section; setting the surface of the liquid guiding section as an inwardly concave arc surface can make the liquid flow smoother.

[0043] (4) The driving teeth of the present invention increase the friction of the driving component. The driving teeth mesh with the rack to prevent the user from slipping when pushing and pulling the driving component. The user holds the housing with one hand and then uses the thumb of the same hand to turn the driving component, so that the valve body can be pushed and pulled with one hand, which further facilitates the user to operate the indwelling needle with one hand.

[0044] (5) The present invention uses a first mixing chamber unit instead of a second syringe. The user only needs to hold the first syringe with one hand and push the piston of the first syringe to prepare bubble developer. Unlike the prior art, where the user holds the first syringe with one hand and the second syringe with the other hand, and the two syringes push against each other to mix the aspirated blood with saline and air, the present invention only requires one hand, which further facilitates the preparation of bubble developer.

[0045] (6) The fourth limiting groove and the limiting protrusion of the present invention engage, and the two ends of the second liquid transfer hole are respectively connected to the first interface and the third interface. The bubble developer can be transferred between the first syringe and the second mixing chamber unit. The second mixing chamber unit can participate in the preparation of bubble developer and can also be used to store bubble developer. The user can use the first syringe to prepare bubble developer in conjunction with the first mixing chamber unit. Then, the user can store the first part of bubble developer in the first syringe, the second part of bubble developer in the first mixing chamber unit, and the third part of bubble developer in the second mixing chamber unit for later use. Bubble developer for three uses can be prepared at once, saving preparation time.

[0046] In this invention, the above-described technical solutions can be combined with each other to achieve more preferred combinations. Other features and advantages of this invention will be set forth in the following description, and some advantages may become apparent from the specification or be learned by practicing the invention. The objectives and other advantages of this invention can be realized and obtained from the content specifically pointed out in the text and drawings. Attached Figure Description

[0047] Figure 1 This is a schematic diagram of the overall structure of an indwelling needle;

[0048] Figure 2 This is a schematic diagram of the internal structure of the mixing unit, control valve unit, and first push-pull unit in Example 1;

[0049] Figure 3 This is a side view of the hybrid unit and the first push-pull unit in Embodiment 1;

[0050] Figure 4 This is a schematic diagram of the overall structure of the valve body;

[0051] Figure 5 This is a schematic diagram of the structure of the mixing unit and the second push-pull unit in Example 2;

[0052] Figure 6 This is a schematic diagram of the internal structure of the mixing unit, control valve unit, and second push-pull unit in Example 2;

[0053] Figure 7 This is a front view schematic diagram of the mixing unit and control valve unit in Example 3;

[0054] Figure 8 This is a schematic diagram of the internal structure of the mixing unit and control valve unit in Example 3.

[0055] Figure label:

[0056] 1-Injection unit; 2-Mixing unit; 3-Control valve unit; 4-First push-pull unit; 5-Second push-pull unit; 6-First mixing chamber unit; 7-Second mixing chamber unit; 11-Indwelling needle body; 12-Liquid passage tube; 21-Housing shell; 22-First interface; 23-Second interface; 24-Limiting protrusion; 25-Slide groove; 26-Rack; 27-Third interface; 31-Valve body; 32-First liquid transmission hole; 33-First limiting groove; 3 4-Second limiting groove; 35-Third limiting groove; 36-Second liquid transfer hole; 37-Fourth limiting groove; 41-Force application plate; 42-Reaction horizontal plate; 43-Reaction side plate; 44-Reinforcing rod; 51-Drive component; 52-Connecting rod; 53-Rotating shaft; 61-First cylinder; 62-First piston; 63-First spring; 64-First vent hole; 71-Second cylinder; 72-Second piston; 73-Second spring; 74-Second vent hole. Detailed Implementation

[0057] The specific embodiments of the present invention are described below to enable those skilled in the art to understand the present invention. However, it should be understood that the present invention is not limited to the scope of the specific embodiments. For those skilled in the art, various changes are obvious as long as they are within the spirit and scope of the present invention as defined and determined by the appended claims. All inventions utilizing the concept of the present invention are protected.

[0058] Example 1:

[0059] like Figure 1 As shown, an indwelling needle for transcranial Doppler ultrasound imaging (hereinafter referred to as the indwelling needle) includes an injection unit 1, a mixing unit 2, and a control valve unit 3. The injection unit 1 is connected to the mixing unit 2, and the control valve unit 3 is disposed within the mixing unit 2. The mixing unit 2 is used to prepare a bubble contrast agent and inject it into the human body through the injection unit 1. The control valve unit 3 is used to switch the preparation and delivery path of the bubble contrast agent.

[0060] Preferably, the injection unit 1 includes an indwelling needle body 11 and a fluid inlet tube 12. The indwelling needle body 11 is connected to the mixing unit 2 through the fluid inlet tube 12. The bubble developer prepared by the mixing unit 2 is delivered to the indwelling needle body 11 through the fluid inlet tube 12 and then injected into the human body.

[0061] Preferred, such as Figure 2As shown, the mixing unit 2 includes a housing 21, a first interface 22, and a second interface 23. The first interface 22 and the second interface 23 are disposed opposite each other on both sides of the housing 21. One end of the housing 21 is connected to the liquid inlet tube 12, which is the liquid inlet end. The housing 21 includes a hollow part, and the control valve unit 3 is disposed in the hollow part. The first interface 22 is used to connect to the first syringe (not shown in the figure), and the second interface 23 is used to connect to the second syringe (not shown in the figure). The liquid and gas of the first syringe and the second syringe can be exchanged through the mixing unit 2 to prepare a bubble developer.

[0062] Preferably, the control valve unit 3 includes a valve body 31 and a first liquid transmission hole 32. The valve body 31 is disposed in the hollow part of the housing 21, and the first liquid transmission hole 32 is disposed on the valve body 31. The valve body 31 is used to seal the hollow part and adjust the liquid flow direction in the hollow part. The first liquid transmission hole 32 is used to connect the first interface 22 and the second interface 23, so that the bubble developer can flow between the first interface 22 and the second interface 23.

[0063] Preferably, the end of the valve body 31 near the liquid inlet pipe 12 is a liquid guiding section, which is a wedge-shaped liquid guiding section. The liquid guiding section can block the second interface 23 and connect the first interface 22 to the liquid inlet pipe 12. Preferably, the surface of the liquid guiding section is a concave arc surface, which makes the liquid delivery smoother; and the outer diameter of the valve body 31 is the same as the inner diameter of the housing 21, so the valve body 31 can effectively block the housing 21.

[0064] Preferred, such as Figure 2 and Figure 4 As shown, the mixing unit 2 also includes a limiting protrusion 24, which is disposed on the inner wall of the housing 21. The control valve unit 3 also includes a first limiting groove 33, a second limiting groove 34, and a third limiting groove 35, which are sequentially arranged along the axial direction of the valve body 31 and are all circumferentially formed on the outer wall surface of the valve body 31. The limiting protrusion 24 is used to prevent relative displacement between the valve body 31 and the housing 21, ensuring the accurate position of the valve body 31 within the housing 21.

[0065] Preferably, when the first limiting groove 33 and the limiting protrusion 24 engage, the fluid inlet, the first interface 22, and the second interface 23 are all in a closed state. When the second limiting groove 34 and the limiting protrusion 24 engage, the fluid inlet is in a closed state, and the first interface 22 and the second interface 23 are in a connected state. When the third limiting groove 35 and the limiting protrusion 24 engage, the first interface 22 and the fluid inlet are in a connected state, and the second interface 23 is in a closed state. When the limiting protrusion 24 engages with the first limiting groove 33, the second limiting groove 34, or the third limiting groove 35 respectively, the user can clearly perceive the segmentation and understand whether the connection between each limiting groove and the limiting protrusion 24 is established. At the same time, the user can clearly know the relative positional relationship between the valve body 31 and the housing 21, which facilitates surgical operations.

[0066] Preferred, such as Figure 2 and Figure 3 As shown, to facilitate pushing and pulling the control valve unit 3, the indwelling needle in this embodiment also includes a first push-pull unit 4. The first push-pull unit 4 includes a force-applying plate 41, a reaction horizontal plate 42, and a reaction side plate 43. The force-applying plate 41 is connected to the valve body 31 and is rectangular. There are two reaction side plates 43, which are respectively disposed at both ends in the width direction of the force-applying plate 41. The reaction horizontal plate 42 is disposed parallel to the force-applying plate 41 at the top of the reaction side plate 43. The user can use two fingers to pull the force-applying plate 41 to pull the valve body 31 out of the housing 21, or the user can use one finger to push the reaction horizontal plate 42 to push the valve body 31 into the housing 21, which greatly facilitates the user's operation.

[0067] Preferably, the valve body 31 is cylindrical, the hollow part of the housing 21 is a cylindrical hollow part, the outer wall of the housing 21 is a square cylindrical outer wall, and one end of the reaction cross plate 42 can be connected to the outer wall of the housing 21, thereby preventing the valve body 31 from rotating circumferentially and ensuring that the liquid guiding section can block the second interface 23.

[0068] Preferably, a reinforcing rod 44 is provided between the reaction side plate 43 and the reaction horizontal plate 42. One end of the reinforcing rod 44 is connected to the reaction side plate 43, and the other end of the reinforcing rod 44 is connected to the reaction horizontal plate 42. The reinforcing rod 44 is used to strengthen the connection between the reaction side plate 43 and the reaction horizontal plate 42, and to prevent the reaction horizontal plate 42 from rotating around the end of the reaction side plate 43, which would cause operation failure.

[0069] The initial state of mixing unit 2 is that the first limiting groove 33 and the limiting protrusion 24 are engaged, and the liquid inlet end, the first interface 22, and the second interface 23 are all closed. During use, the valve body 31 needs to be pulled up first to engage the third limiting groove 35 and the limiting protrusion 24, making the first interface 22 and the liquid inlet connected, while the second interface 23 is closed. Blood is drawn from the patient through the first syringe connected to the first interface 22, which is filled with saline solution. The drawn blood and saline solution mix to form a mixture. After the blood is drawn, the valve body 31 is pressed down to engage the third limiting groove 35 and the limiting protrusion 24. When the second limiting groove 34 and the limiting protrusion 24 are engaged, the liquid inlet is in a closed state. The first interface 22 and the second interface 23 are connected. At this time, the first syringe and the second syringe push against each other to make the mixture fully mixed. After the mixture is fully mixed, the bubble contrast agent is prepared and injected into the first syringe. Then, the valve body 31 is pulled to make the third limiting groove 35 and the limiting protrusion 24 engage. The first interface 22 and the liquid inlet are in a connected state, and the second interface 23 is in a closed state. The bubble contrast agent is injected into the patient's body through the liquid inlet and the injection unit 1, and the image is observed at the same time to complete the experiment.

[0070] Compared to existing technologies, fixing the mixing unit 2 to the injection unit 1 avoids the need for on-site connection between the mixing unit 2 and the injection unit 1 during use. The valve body 31 is slidably positioned within the mixing unit 2, allowing for the closure of each end of the mixing unit 2. Furthermore, the control valve unit 3 provides limit positioning for each closure stage. Compared to existing rotary three-way infusion connectors, the limit positioning via the control valve unit 3 provides clearer sensing and a more stable valve closure, preventing crossflow. Three limiting grooves and a limiting protrusion 24 are provided, each corresponding to a specific closure state. The control valve unit 3 serves both a limiting and sealing function. The inclusion of a first push-pull unit 4 and a force-applying structure on the top of the valve body 31 facilitates pushing and pulling the valve body 31, with a strong counterforce. Plate 42 serves as the point of leverage for the operator's palm, with fingers and middle fingers hooking onto the force-applying structure for easy lifting of the valve body 31. The hollow portion of the housing 21 is cylindrical, and the outer wall of the housing 21 is a square cylindrical outer wall. One end of the reaction plate 42 can connect to the outer wall of the housing 21, thereby preventing the valve body 31 from rotating circumferentially and ensuring that the liquid guiding section can seal the second interface 23, avoiding the situation where the liquid guiding section deflects and the hollow portion is not tightly sealed, resulting in crossflow. The two ends of the force-applying plate 41 are further extended beyond the two ends of the reaction plate 42 to facilitate the operator's pressing operation on the valve body 31 through the force-applying plate 41. The reinforcing rod 44 increases the stability between the reaction side plate 43 and the reaction plate 42, preventing the reaction plate 42 from rotating around the end of the reaction side plate 43, which could cause operational failure. The surface of the liquid guiding section is designed as a concave arc surface to make the liquid flow smoother.

[0071] Example 2:

[0072] To facilitate one-handed operation of the indwelling needle, such as Figure 5 As shown, this embodiment replaces the first push-pull unit 4 with the second push-pull unit 5, and improves the mixing unit 2 of embodiment 1. The user can hold the mixing unit 2 with one hand and push and pull the valve body 31 of the control valve unit 3 with one hand, which is simple and quick to operate.

[0073] Preferred, such as Figure 6 As shown, compared to Embodiment 1, the housing 21 is lengthened, and the mixing unit 2 adds a sliding groove 25, which is disposed on the inner wall of one end of the housing 21. The second push-pull unit 5 includes a drive member 51, a connecting rod 52, and a rotating shaft 53. One end of the connecting rod 52 is connected to the valve body 31, and the other end of the connecting rod 52 is rotatably connected to the rotating shaft 53. The rotating shaft 53 is fixedly connected to the drive member 51, and the drive member 51 can rotate around the rotating shaft 53. The end of the rotating shaft 53 is disposed in the sliding groove 25, and the drive member 51 can slide along the sliding groove 25. The user can hold the housing 21 with one hand and then use the thumb of the same hand to push and pull the drive member 51 to perform push-pull operation on the valve body 31 with one hand, which is convenient for the user to operate the indwelling needle with one hand.

[0074] Preferably, the mixing unit 2 further includes a rack 26, which is disposed on the inner wall of the housing 21. The drive element 51 is a hand gear, which includes drive teeth that can connect with the rack 26. The drive teeth increase the friction of the drive element 51, and the meshing of the drive teeth with the rack 26 prevents slippage when the user pushes or pulls the drive element 51; the user can hold the housing 21 with one hand and then use the thumb of the same hand to turn the drive element 51, thus performing push and pull operations on the valve body 31 with one hand, further facilitating the user's one-handed operation of the indwelling needle.

[0075] Example 3:

[0076] like Figure 7 As shown, this embodiment further improves the structure of the mixing unit 2 and the control valve unit 3 of embodiment 1 or 2, so that the indwelling needle of this embodiment can be operated with one hand.

[0077] In existing technology, the user holds a first syringe in one hand and a second syringe in the other. The two syringes push against each other to mix the aspirated blood with saline and air, requiring both hands to prepare the bubble contrast agent. Preferably, as... Figure 7 As shown, the indwelling needle in this embodiment also includes a first mixing chamber unit 6, which is used to replace the second syringe and works together with the first syringe to prepare bubble developer.

[0078] Preferred, such as Figure 8As shown, the first mixing chamber unit 6 includes a first cylinder 61, a first piston 62, and a first spring 63. One end of the first cylinder 61 is connected to the second interface 23, and the other end of the first cylinder 61 is a free end. The first piston 62 and the first spring 63 are both disposed in the hollow part of the first cylinder 61. One end of the first spring 63 is connected to the first piston 62, and the other end of the first spring 63 is connected to the free end of the first cylinder 61. The first spring 63 is used to push the first piston 62 toward the second interface 23. The first piston 62 is used to push the bubble developer in the hollow part of the first cylinder 61 out of the first cylinder 61, so that the bubble developer returns to the first syringe.

[0079] Preferably, the first mixing chamber unit 6 further includes a first vent 64, which is disposed on the free end of the first cylinder 61. The first vent 64 is used to balance the air pressure inside the first cylinder 61 when bubble developer is introduced and exported in the first cylinder 61.

[0080] In clinical applications, due to individual differences, some cases require the use of multiple portions of bubble contrast agent. Users operating the indwelling needles described in Examples 1 or 2 will need to prepare the bubble contrast agent multiple times. Preferably, as... Figure 7 and Figure 8 As shown, the mixing unit 2 also includes a third interface 27, which is disposed on the housing 21. The indwelling needle in this embodiment also includes a second mixing chamber unit 7, the structure of which is the same as the first mixing chamber unit 6. The second mixing chamber unit 7 includes a second cylinder 71, a second piston 72, a second spring 73, and a second vent 74. The second cylinder 71 is connected to the third interface 27. The second mixing chamber unit 7 is used in conjunction with the first syringe to prepare and store bubble developer.

[0081] Preferably, to control the connection between the second mixing chamber unit 7 and the first syringe, the control valve unit 3 further includes a second liquid transfer hole 36. The second liquid transfer hole 36 is disposed on the valve body 31 and is used to connect the first interface 22 and the third interface 27, allowing the bubble developer to flow between the first interface 22 and the third interface 27. In use, the user can use the first syringe to prepare the bubble developer in conjunction with the first mixing chamber unit 6. After preparing the bubble developer, the first portion of the bubble developer is stored in the first syringe, the second portion is stored in the first mixing chamber unit 6, and the third portion is stored in the second mixing chamber unit 7 for later use. This allows for the preparation of bubble developer for three uses in one go, greatly saving preparation time.

[0082] Preferably, to position the second liquid transfer hole 36 within the valve body 31, the control valve unit 3 further includes a fourth limiting groove 37. The fourth limiting groove 37 is disposed on the valve body 31, and its shape is the same as that of the first limiting groove 33. The fourth limiting groove 37 engages with the limiting protrusion 24. The two ends of the second liquid transfer hole 36 are respectively connected to the first interface 22 and the third interface 27. During use, the bubble developer can be transferred between the first syringe and the second mixing chamber unit 7. The second mixing chamber unit 7 can participate in the preparation of the bubble developer and can also be used to store the bubble developer.

[0083] In this embodiment, the first mixing chamber unit 6 replaces the second syringe. The user only needs to hold the first syringe with one hand and push the piston of the first syringe to prepare the bubble developer. Unlike embodiments 1 or 2, where the user holds the first syringe with one hand and the second syringe with the other, and the two syringes push against each other to mix the aspirated blood with saline and air, which requires both hands to prepare the bubble developer, this embodiment only requires one hand, further facilitating the preparation of the bubble developer. The fourth limiting groove 37 and the limiting protrusion 24 engage, and the two ends of the second liquid transfer hole 36 are respectively connected to the first interface 22 and the third interface 27. The bubble developer can be transferred between the first syringe and the second mixing chamber unit 7. The second mixing chamber unit 7 can participate in the preparation of the bubble developer and can also be used to store the bubble developer. The user can use the first syringe, in conjunction with the first mixing chamber unit 6, to prepare bubble developer. After that, the first portion of bubble developer is stored in the first syringe, the second portion is stored in the first mixing chamber unit 6, and the third portion is stored in the second mixing chamber unit 7 for later use. This allows for the preparation of bubble developer for three uses in one go, greatly saving preparation time.

[0084] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in the present invention should be included within the scope of protection of the present invention.

Claims

1. An indwelling needle for transcranial Doppler ultrasound imaging, characterized in that, The device includes an injection unit, a mixing unit, a control valve unit, a first mixing chamber unit, and a second mixing chamber unit. The injection unit, the first mixing chamber unit, and the second mixing chamber unit are respectively connected to the mixing unit. The control valve unit is located inside the mixing unit. The mixing unit is used to prepare bubble developer and inject it into the human body through the injection unit. The control valve unit is used to switch the preparation and delivery path of the bubble developer. The first mixing chamber unit and the second mixing chamber unit are respectively used to work together with the first syringe to prepare and store the bubble developer. The injection unit includes an indwelling needle body and a fluid inlet tube. The indwelling needle body is connected to the mixing unit through the fluid inlet tube. The mixing unit includes a shell, a first interface, a second interface, and a third interface. The first interface and the second interface are disposed opposite to each other on both sides of the shell. One end of the shell is connected to the fluid inlet tube, and this end is the fluid inlet end. The shell includes a hollow part. The first interface is used to connect to the first syringe, and the third interface is disposed on the shell. The control valve unit includes a valve body, a first liquid transmission hole, and a second liquid transmission hole. The valve body is disposed in the hollow part of the housing. Both the first and second liquid transmission holes are disposed on the valve body. The first liquid transmission hole is used to connect the first interface and the second interface, allowing the bubble developer to flow between the first and second interfaces. The end of the valve body near the liquid passage is a liquid guiding section, which can block the second interface and connect the first interface to the liquid passage. The second liquid transmission hole is used to connect the first interface and the third interface, allowing the bubble developer to flow between the first and third interfaces.

2. The indwelling needle for transcranial Doppler ultrasound imaging according to claim 1, characterized in that, The bubble developer prepared by the mixing unit is delivered to the indwelling needle via a liquid-passing tube and then injected into the human body.

3. The indwelling needle for transcranial Doppler ultrasound imaging according to claim 1, characterized in that, The mixing unit also includes a limiting protrusion, which is disposed on the inner wall of the housing.

4. The indwelling needle for transcranial Doppler ultrasound imaging according to claim 3, characterized in that, The control valve unit further includes a first limiting groove, a second limiting groove, and a third limiting groove. The first limiting groove, the second limiting groove, and the third limiting groove are arranged sequentially along the axial direction of the valve body and are all circumferentially formed on the outer wall surface of the valve body. The limiting protrusion can be connected to the first limiting groove, the second limiting groove, or the third limiting groove, respectively.

5. The indwelling needle for transcranial Doppler ultrasound imaging according to claim 4, characterized in that, The control valve unit also includes a fourth limiting groove, which is disposed on the valve body and has the same shape as the first limiting groove.

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