Multi-target transcranial magnetic stimulation nerve regulation system and application thereof in treatment of neurodegenerative diseases

Abstract

The invention relates to the technical field of transcranial magnetic stimulation, and discloses a multi-target transcranial magnetic stimulation nerve regulation and control system and application thereof in treatment of neurodegenerative diseases, during use, a treatment helmet is worn on the head of a patient, and a physician can adjust the head shape of the patient according to the head shape of each patient. The to-be-stimulated area is accurately positioned by sliding the annular telescopic positioning assembly on the treatment helmet, then the first TMS stimulation beat and the second TMS stimulation beat are detachably connected to the corresponding to-be-stimulated area, and the first TMS stimulation beat and the second TMS stimulation beat are utilized to perform double-beat type transcranial magnetic stimulation on a patient, so that the brain region motion loop of the patient can be fully activated, and the stimulation effect of the patient is improved. And the treatment efficiency and quality are greatly improved.

Description

Technical Field

[0001] The present invention relates to the technical field of transcranial magnetic stimulation, and in particular to a multi-target transcranial magnetic stimulation neural regulation system and its application in the treatment of neurodegenerative diseases. Background Art

[0002] Neurological diseases are disorders involving structural or functional abnormalities of the central and peripheral nervous systems, including neurodegenerative diseases, mental disorders, cerebrovascular diseases, neurodevelopmental disorders, cognitive impairment, and movement disorders. These diseases often have complex etiologies and diverse pathological mechanisms. Traditional drug treatments have limited efficacy and are often accompanied by adverse reactions, necessitating an urgent need for new and effective treatments.

[0003] Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique based on Faraday's law of electromagnetic induction. It generates a rapidly changing, strong, focal magnetic field outside the scalp, inducing electrical currents in cerebral cortical neurons. This, in turn, causes changes in the membrane potential of the cell bodies or axon terminals, thereby regulating neuronal excitability and information transmission within the neuronal network. TMS was first used for cerebral cortical stimulation in humans in 1985 and has since undergone numerous technological iterations. Repetitive transcranial magnetic stimulation (rTMS), a key variant of TMS, was introduced into clinical practice in 1989. Its characteristic is the repeated application of magnetic stimulation at a specific frequency, resulting in different neuromodulatory effects depending on the stimulation frequency: low-frequency rTMS (≤1Hz) typically produces inhibitory effects, while high-frequency rTMS (>1Hz) produces excitatory effects.

[0004] In recent years, TMS has been widely used in the diagnosis and treatment of a variety of neurological diseases, including neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis; mental disorders such as depression, anxiety, and obsessive-compulsive disorder; stroke and its sequelae; pain-related diseases such as chronic pain, fibromyalgia, neuropathic pain, and migraine; and other neurological dysfunctions such as epilepsy, multiple sclerosis, vertigo, tinnitus, and attention deficit hyperactivity disorder.

[0005] TMS has multiple mechanisms of action at the cellular and molecular levels, including promoting synaptic plasticity, regulating neurotransmitter balance, promoting the expression of neurotrophic factors, modulating neuroinflammatory responses, improving cerebral blood flow and metabolism, reducing pathological protein deposition, and regulating neural network connectivity. These mechanisms enable TMS to be widely used in the treatment of various neurological diseases. Through stimulation of varying frequencies and patterns, it can specifically regulate abnormal neural activity and improve corresponding clinical symptoms.

[0006] However, existing transcranial magnetic stimulation technology still has certain limitations, which are mainly reflected in two aspects: First, traditional TMS usually adopts a single target stimulation mode, in which the physician manually places the stimulation coil at a specific location on the patient's scalp to perform a single type of stimulation. This method makes it difficult to fully activate and regulate the complex neural networks composed of multiple functionally related brain regions in the nervous system, resulting in poor neuromodulation effects. In particular, for functions that involve the collaborative work of multiple brain regions, such as motor coordination, if the key nodes in the relevant neural circuits cannot be activated simultaneously or sequentially, patients will face significant challenges in recovering their motor control and coordination abilities. Secondly, single-target stimulation strategies often require extended treatment cycles to achieve ideal results. Patients usually need to undergo continuous treatment for several months or even longer before observing significant symptom improvement. This not only increases the psychological burden on patients and makes compliance difficult, but may also lead to a decrease in confidence in treatment. At the same time, long-term repeated visits to the doctor also have a significant impact on patients' daily life, work, and social activities.

[0007] Therefore, there is a need in the art for a TMS neuromodulatory device capable of implementing multi-target stimulation to overcome the application limitations of existing devices. Summary of the Invention

[0008] The present invention provides a multi-target transcranial magnetic stimulation neuroregulatory system and its application in the treatment of neurodegenerative diseases, in order to solve the defects of existing transcranial magnetic stimulation methods that cannot fully activate the motor circuits of brain areas, have a long treatment cycle, and result in poor treatment effects. The multi-target transcranial magnetic stimulation neuroregulatory system of the present invention can, on the one hand, assist physicians in accurately locating the patient's brain area and adopt a multi-target collaborative stimulation strategy. It can also activate multiple functionally related brain areas simultaneously or in a specific time sequence, effectively mobilizing the overall functional network of the nervous system, thereby significantly improving treatment efficiency and clinical efficacy. This system is particularly suitable for complex neurological dysfunctions that require the collaborative participation of multiple brain areas, such as motor coordination disorders, cognitive dysfunction, and neuropsychiatric diseases.

[0009] The present invention provides a multi-target transcranial magnetic stimulation device, comprising a treatment helmet, a ring-shaped telescopic positioning component, a first TMS stimulation paddle, and a second TMS stimulation paddle. The ring-shaped telescopic positioning component is arranged on the treatment helmet and can move up and down along the longitudinal direction of the treatment helmet. The first TMS stimulation paddle and the second TMS stimulation paddle can be detachably connected to the ring-shaped telescopic positioning component respectively.

[0010] In the present invention, TMS stimulation can use various types of TMS coils to meet the needs of stimulating brain regions with different depths and precisions. The TMS coils include but are not limited to: Round coil: The earliest type of TMS coil developed, it produces a wider magnetic field distribution, with a large stimulation range but lower precision. It is suitable for motor threshold measurement and large-scale cortical stimulation, with a stimulation depth of about 1-2 cm.

[0011] Figure-of-8 / Butterfly coil: It consists of two adjacent circular coils, which produce maximum magnetic field strength at the intersection, providing more focused stimulation. It is the most commonly used standard coil and is suitable for precise targeting of cortical areas such as the motor cortex and dorsolateral prefrontal cortex, with a stimulation depth of approximately 2-3 cm.

[0012] Double cone coil: Two circular coils intersecting at a large angle produce a stronger and deeper magnetic field distribution, which is particularly suitable for stimulating deep midline structures such as the motor area lower limb representation area and the supplementary motor area, with a stimulation depth of up to 3-4 cm.

[0013] H-coil: A series of coils specially designed for deep TMS that can stimulate deeper brain structures without increasing the intensity of surface stimulation. It is suitable for stimulating deep structures such as the limbic system and basal ganglia, with a stimulation depth of up to 5-7 cm.

[0014] Cone coil: A specially designed coil with a conical magnetic field distribution, which can achieve more precise directional stimulation of deep brain areas. It is suitable for targeted regulation of structures such as the cerebellum and anterior cingulate cortex, with a stimulation depth of approximately 3-5 cm.

[0015] D-shaped coil: A coil shaped like the letter D, designed for stimulating specific anatomical structures, such as specific areas of the temporal or parietal lobes, providing focusing performance between that of a circular and figure-of-eight coil.

[0016] Cooled coil systems: Coils equipped with liquid cooling systems, such as the Cool-B and Cool-D models, can maintain stable performance during prolonged high-intensity stimulation and are suitable for high-intensity protocols such as theta burst stimulation.

[0017] Mini-coils: Small, lightweight coils suitable for precise stimulation of children or specific anatomical areas, as well as for scenarios where other neuroimaging studies need to be performed simultaneously.

[0018] Cloverleaf coil: Consists of three intersecting coils that produce a highly focused magnetic field, suitable for stimulating brain areas that require ultra-precise targeting.

[0019] Multi-ring coil: Consists of multiple concentric ring coils. The current ratio of each ring can be adjusted to optimize stimulation depth and focus, making it suitable for personalized and precise stimulation plans.

[0020] Preferably, the first TMS stimulation pulse and the second TMS stimulation pulse are different types of coils. This allows for adaptability to various conditions and treatment needs. In a specific embodiment, the first TMS stimulation pulse and the second TMS stimulation pulse can be a combination of coils suitable for stimulating brain regions at different depths. For example, the first TMS stimulation pulse is a conical coil, and the second TMS stimulation pulse is a circular coil.

[0021] By combining these various coil types, comprehensive stimulation coverage from the superficial cortex to deep brain structures can be achieved. The most appropriate coil type and combination can be selected based on the patient's specific condition and treatment needs to achieve optimal neuromodulation. The coordinated use of different coil types can simultaneously or sequentially stimulate multiple functionally related brain regions at varying depths, effectively activating and modulating complex neural networks and significantly improving treatment efficiency and clinical efficacy.

[0022] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the annular telescopic positioning assembly includes a first annular telescopic positioning shaft and a first positioning fastener. The first annular telescopic positioning shaft can move up and down along the longitudinal direction of the treatment helmet, and the first positioning fastener is used to fix the first annular telescopic positioning shaft on the treatment helmet. The first TMS stimulation rack and the second TMS stimulation rack can be detachably connected to the first annular telescopic positioning shaft respectively.

[0023] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the annular telescopic positioning assembly also includes a second annular telescopic positioning shaft and a second positioning fastener. The second annular telescopic positioning shaft is arranged parallel to the first annular telescopic positioning shaft, and the second annular telescopic positioning shaft can also move up and down along the longitudinal direction of the treatment helmet. The second positioning fastener is used to fix the second annular telescopic positioning shaft on the treatment helmet, and the first TMS stimulation rack and the second TMS stimulation rack can be detachably connected to the second annular telescopic positioning shaft respectively.

[0024] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the treatment helmet includes a head ring and a curved first ruler. The curved first ruler is arranged on the head ring and forms an internal space with the head ring that can accommodate the patient's head. The annular telescopic positioning assembly is arranged on the curved first ruler and can move up and down along the curved first ruler.

[0025] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the treatment helmet further includes a curved second ruler, which is arranged on the head circumference ring and intersects with the curved first ruler in a cross shape.

[0026] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the curved first ruler and / or the curved second ruler are provided with a track along their curved direction, so that the annular telescopic positioning assembly can move up and down along the curved first ruler and / or the curved second ruler.

[0027] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the treatment helmet includes a first helmet fixing knob and a first helmet fixing gasket, the first helmet fixing knob is arranged on the top of the treatment helmet and the knob portion of the first helmet fixing knob is located outside the treatment helmet, the free end is located inside the treatment helmet, and the first helmet fixing gasket is arranged at the free end of the first helmet fixing knob.

[0028] According to a multi-target transcranial magnetic stimulation device provided by the present invention, the treatment helmet includes a second helmet fixing knob and a second helmet fixing gasket, the second helmet fixing knob is arranged on the side of the treatment helmet and the knob portion of the second helmet fixing knob is located outside the treatment helmet, the free end is located inside the treatment helmet, and the second helmet fixing gasket is arranged at the free end of the second helmet fixing knob.

[0029] According to a multi-target transcranial magnetic stimulation device provided by the present invention, a plurality of helmet fixing assemblies formed by a combination of the second helmet fixing knob and the second helmet fixing gasket are provided, and are respectively arranged at equal distances on the side faces of the treatment helmet in the horizontal direction.

[0030] According to the present invention, a multi-target transcranial magnetic stimulation device further includes a load-bearing rod, and the treatment helmet and the load-bearing rod are detachably connected and relatively movable.

[0031] Due to the large mass of the treatment helmet and the dual-paddles, a certain amount of pressure is exerted on the patient's head during treatment, potentially causing discomfort and leading to head movement, which in turn shifts or offsets the dual-paddles, affecting the stimulation effect. By connecting the load-bearing rods to external support components such as exoskeleton systems or other wearable devices, the pressure can be directed and distributed to the external support components, making the therapeutic effects of the transcranial magnetic stimulation device and system of the present invention more stable and effective.

[0032] The present invention also provides a multi-target transcranial magnetic stimulation neural regulation system implemented based on any of the multi-target transcranial magnetic stimulation devices described above, comprising: Control terminal: used for setting a stimulation scheme and sending stimulation instructions to the stimulation signal generating module, wherein the stimulation scheme is determined based on the position data of the brain area to be stimulated of the subject input by the user; The stimulation signal generating module is used to: respond to the stimulation instruction issued by the control terminal to cause the first TMS stimulation beat and the second TMS stimulation beat located in the area to be stimulated to generate magnetic stimulation according to the stimulation scheme set in the stimulation instruction.

[0033] According to the multi-target transcranial magnetic stimulation neuroregulatory system provided by the present invention, the control terminal includes a processor and a memory, and the memory stores preset stimulation schemes, treatment data, etc. for various treatment purposes. Preferably, the control terminal also includes various communication interfaces and components required to support access to the telemedicine system and corresponding communication protocols. The control terminal may also include input and output modules. After the subject wears the treatment helmet, the user (for example, medical staff) locates the area to be stimulated according to the subject's brain using the annular telescopic positioning assembly, and then the position data of the area to be stimulated can be input into the control terminal through the input and output modules.

[0034] In a preferred embodiment, the control terminal can also be configured to modify the preset stimulation scheme in the memory in response to user input. The stimulation scheme includes stimulation parameters and stimulation time, and the stimulation parameters include frequency, intensity, sequence and interval of stimulation.

[0035] In the present invention, the stimulation signal generation module can be implemented using a magnetic stimulation generator commonly used in the art. For example, relevant parameters of the magnetic stimulation generator may include: a continuously adjustable frequency range of generally 0.1-100 Hz, a magnetic field strength range of 1.5-8 T, a magnetic induction intensity change rate of greater than or equal to 40 kT / s to ensure effective nerve depolarization, and compatibility with multiple stimulation modes.

[0036] The multi-target transcranial stimulation neuroregulatory system of the present invention can be set up independently of the transcranial stimulation device, and can be connected to various transcranial stimulation devices or TMS stimulation beats through communication interfaces and cables, or can be integrated with the multi-target transcranial magnetic stimulation device of the present invention. In the case of an integrated system, the multi-target transcranial stimulation neuroregulatory system of the present invention includes the multi-target transcranial magnetic stimulation device of the present invention, a control terminal and a stimulation signal generating module, wherein the stimulation signal generating module is electrically connected to the first TMS stimulation beat and the second TMS stimulation beat of the multi-target transcranial stimulation device, and is used to generate and output a magnetic stimulation signal to the first TMS stimulation beat and the second TMS stimulation beat, so that magnetic stimulation occurs. The control terminal is communicatively connected to the stimulation signal generating module, and after the user (for example, a doctor) installs the treatment helmet on the subject, the control terminal sends a stimulation instruction to the stimulation signal generating module after setting the stimulation scheme in response to the user's input.

[0037] The multi-target transcranial magnetic stimulation neuromodulation system provided by the present application is used for treating the following diseases or functional disorders of the subject to be measured: neurodegenerative diseases, mental disorders, cognitive disorders, movement disorders, sensory disorders, pain-related diseases, post-stroke sequelae, post-traumatic brain injury sequelae, neurodevelopmental disorders, sleep disorders, drug addiction and other nervous system-related diseases.

[0038] The neurodegenerative diseases include but are not limited to Alzheimer's disease, Parkinson's disease, Lewy body dementia, frontotemporal dementia, vascular dementia, Huntington's disease, amyotrophic lateral sclerosis (ALS), multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, multiple sclerosis, spinocerebellar ataxia, primary progressive aphasia, postcortical atrophy, normal pressure hydrocephalus, prion disease, neuronal synaptopathy and other types of neuronal degenerative diseases.

[0039] The mental disorders include but are not limited to depression (including treatment-resistant depression), anxiety, bipolar disorder, schizophrenia, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), generalized anxiety disorder, social anxiety disorder, panic disorder, borderline personality disorder, dependent personality disorder, avoidant personality disorder, schizoid personality disorder, narcissistic personality disorder, antisocial personality disorder, adjustment disorder, dissociative disorder, somatic symptom disorder, hypochondriasis, sexual psychopathology, sexual dysfunction and other types of mental and psychological disorders.

[0040] The cognitive disorders include but are not limited to mild cognitive impairment, attention deficit hyperactivity disorder (ADHD), learning disorders, memory disorders, executive function disorders, language disorders, visual-spatial ability disorders, cognitive flexibility disorders.

[0041] The movement disorders include but are not limited to tremor, muscle tone disorder, muscle rigidity, chorea, myoclonus, movement coordination disorder, ataxia, involuntary movement, extrapyramidal symptoms, muscle weakness, movement slowness, muscle atrophy, spasm, movement control disorder.

[0042] The sensory disorders include but are not limited to hyperesthesia, hyposesthesia, sensory loss, paresthesia, hallucination, auditory hallucination, visual hallucination, illusion, sensory processing disorder.

[0043] The pain-related diseases include but are not limited to chronic pain syndrome, neuropathic pain, fibromyalgia, complex regional pain syndrome, migraine, cluster headache, tension headache, trigeminal neuralgia, peripheral neuralgia, post-herpetic neuralgia.

[0044] The sequelae of stroke include but are not limited to motor dysfunction, language disorders, swallowing disorders, cognitive disorders, emotional disorders, sensory disorders, central pain, hemiplegia, ataxia, language expression disorders, reading disorders, and writing disorders.

[0045] The sequelae of brain trauma include but are not limited to cognitive impairment, mood disorders, behavioral disorders, movement disorders, sensory disorders, consciousness disorders, headaches, dizziness, balance disorders, attention disorders, memory disorders, and executive dysfunction.

[0046] Neurodevelopmental disorders include, but are not limited to, autism spectrum disorders, intellectual disability, communication disorders, specific learning disabilities, movement disorders, tic disorders, and Tourette syndrome.

[0047] Sleep disorders include, but are not limited to, insomnia, sleep apnea, narcolepsy, hypersomnia, circadian rhythm sleep disorders, paradoxical sleep, sleep terrors, sleepwalking, nightmare disorders, and rapid eye movement sleep behavior disorder.

[0048] Drug addiction includes but is not limited to alcohol dependence, nicotine dependence, opioid dependence, marijuana dependence, cocaine dependence, amphetamine dependence, sedative-hypnotic dependence, hallucinogen dependence, inhalant dependence and dependence on other psychoactive substances.

[0049] Other neurological diseases include but are not limited to epilepsy, tinnitus, vertigo, polyneuritis, Guillain-Barré syndrome, myasthenia gravis, periodic paralysis, metabolic encephalopathy, ischemic encephalopathy, infectious encephalopathy, autoimmune encephalitis, intracranial hypertension, hydrocephalus, sequelae of spinal cord injury, impaired consciousness, vegetative state, minimally conscious state, locked-in syndrome, and coma.

[0050] In a preferred embodiment, the multi-target transcranial magnetic stimulation device in the multi-target transcranial magnetic stimulation neural regulation system can be integrated into the exoskeleton through a reserved interface, so as to realize the coordinated TMS transcranial magnetic stimulation during the exoskeleton rehabilitation training. To realize the dual collaborative rehabilitation training mode of movement and cognition, the system is connected to the exoskeleton device through a standardized electrical and communication interface (including USB, CAN bus, Bluetooth, etc.), supports three stimulation timing modes before, during and after movement, and can automatically adjust the TMS stimulation targets and parameters according to the exoskeleton movement parameters. The system has multi-modal collaborative training functions, including passive movement collaborative stimulation, active auxiliary movement collaborative stimulation and resistance movement collaborative stimulation, etc., and is equipped with a real-time data recording module, which can synchronously collect limb movement data and brain area activation data. The system supports personalized rehabilitation program design and can dynamically adjust the collaborative stimulation parameters according to the patient's condition, rehabilitation stage and progress. This integrated system is particularly suitable for the recovery of motor function in patients with stroke, spinal cord injury, Parkinson's disease, multiple sclerosis, etc. It can also be used for rehabilitation training of craniocerebral injury, peripheral nerve injury and cerebral palsy in children. By simultaneously activating relevant brain areas and executing limb movements, a closed-loop neural feedback system is formed to promote the coordinated recovery of central and peripheral nerve functions, significantly improving motor learning ability and neural remodeling efficiency.

[0051] In a preferred embodiment, the multi-target transcranial magnetic stimulation device in the multi-target transcranial magnetic stimulation neuroregulatory system can be integrated into the brain-computer interface through a reserved interface to realize a bidirectional closed-loop neuroregulatory system. The system is equipped with standardized data interfaces (including USB, optical fiber, Ethernet, etc.) and supports real-time reception and processing of neural signals from a variety of brain-computer interfaces, including non-invasive (EEG, fNIRS, MEG), semi-invasive (ECoG) and invasive (cortical microelectrode array) brain-computer interfaces. The system has a built-in multi-channel neural signal processing unit that can perform real-time filtering, artifact removal, spectrum analysis, source localization and functional connectivity analysis, and accurately adjust TMS stimulation parameters based on the processing results. The system supports a variety of regulation modes, including inhibition of abnormal neural activity, functional enhancement, neural network modulation and mind control TMS, and has an adaptive safety monitoring mechanism that can monitor neural responses in real time to prevent overstimulation. The system is suitable for the precise treatment of diseases such as epilepsy, depression, obsessive-compulsive disorder, chronic pain, impaired consciousness, attention deficit, memory impairment, and enhanced training of cognitive and psychological functions such as executive function, creativity, and emotional regulation. The system also supports the visualization of the neurorehabilitation process. Through the two-way interaction between brain signals and magnetic stimulation, it builds personalized neuroregulation plans, improves the accuracy and efficacy of neuroregulation, and provides a new technical platform for brain science research and clinical applications.

[0052] The present invention provides a multi-target transcranial magnetic stimulation neural regulation system and its application in the treatment of neurodegenerative diseases. When in use, a treatment helmet is worn on the head of a patient with spinocerebellar ataxia. The doctor can accurately locate the cerebellar hemisphere and motor cortex M1 area to be stimulated by sliding the annular telescopic positioning component on the treatment helmet according to the head shape of each patient. The first TMS stimulation rack and the second TMS stimulation rack are then detachably connected to the corresponding areas to be stimulated, and the first TMS stimulation rack and the second TMS stimulation rack are used to perform multi-target transcranial magnetic stimulation on the patient, which can fully activate the patient's brain area motor circuit and greatly improve the efficiency and quality of treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0053] In order to more clearly illustrate the technical solutions in the present invention or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0054] Figure 1 This is a schematic structural diagram of an embodiment of a multi-target transcranial magnetic stimulation device provided by the present invention.

[0055] Figure 2 It is a structural schematic diagram of an embodiment of a treatment helmet and an annular telescopic positioning assembly.

[0056] Figure 3 A schematic diagram of the therapeutic effect of an embodiment of a multi-target transcranial magnetic stimulation device provided by the present invention.

[0057] Figure 4 This is a structural block diagram of an embodiment of a multi-target transcranial magnetic stimulation system provided by the present invention.

[0058] Figure 5 This is a schematic structural diagram of the electronic device provided by the present invention.

[0059] Reference numerals: 1. Therapeutic helmet; 2. Annular telescopic positioning assembly; 3. First TMS stimulation beat; 4. Second TMS stimulation beat; 5. Load-bearing rod; 101. Head circumference ring; 102. First curved ruler; 103. Second curved ruler; 104. First helmet fixing knob; 105. First helmet fixing gasket; 106. Second helmet fixing knob; 107. Second helmet fixing gasket; 201. First annular telescopic positioning shaft; 202. Second annular telescopic positioning shaft; 203. First positioning fastener; 204. Second positioning fastener. DETAILED DESCRIPTION

[0060] In order to make the purpose, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the drawings in the present invention. Obviously, the embodiments described are part of the embodiments of the present invention, not all of the embodiments, and they should not be understood as limitations on the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. In the description of the present invention, it should be understood that the terms used are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0061] See also Figure 1 The present invention provides an embodiment of a multi-target transcranial magnetic stimulation device (this embodiment may be referred to as a "dual-beat transcranial magnetic stimulation device"), which may include: a treatment helmet 1, an annular telescopic positioning component 2, a first TMS stimulation paddle 3, a second TMS stimulation paddle 4, and a load-bearing rod 5. The annular telescopic positioning component 2 is disposed on the treatment helmet 1 and can move up and down along the longitudinal direction of the treatment helmet 1 and be positioned to assist in locating the area to be stimulated on the wearer's head. The first TMS stimulation paddle 3 and the second TMS stimulation paddle 4 can be rigidly and detachably connected to the annular telescopic positioning component via connectors such as buckles to prevent the positions of the stimulation paddles from changing during treatment. The treatment helmet 1 and the load-bearing rod 5 can be detachably connected via a spherical joint connector, and the treatment helmet 1 can move relative to the load-bearing rod 5, which not only facilitates adjustment of the position (e.g., direction) of the treatment helmet 1, but also shares the weight of the treatment helmet 1, reducing the gravity borne by the wearer's head.

[0062] Specifically, regarding the structure of the treatment helmet 1: On the one hand, the treatment helmet 1 includes a head ring 101, a curved first ruler 102 and a curved second ruler 103. The curved first ruler 102 and the curved second ruler 103 are arranged on the head ring 101 and intersect in a cross shape, and the curved first ruler 102 and the curved second ruler 103 and the head ring 101 form an internal space that can accommodate the patient's head, and the curved first ruler 102 and the curved second ruler 103 are both provided with tracks along their curved directions for the annular telescopic positioning assembly 2 to move up and down along the curved first ruler 102 and the curved second ruler 103.

[0063] The doctor can locate the area to be stimulated on the wearer's head by moving the annular telescopic positioning component 2 on the tracks on the curved first scale 102 and the curved second scale 103, and remember the position of the wearer's area to be stimulated according to the scales on the scales. This can save time in relocating the area to be stimulated during the next treatment, and can ensure the uniformity of the stimulation position for each treatment, effectively improving the treatment efficiency.

[0064] On the other hand, the treatment helmet 1 includes a first helmet fixing knob 104 and a first helmet fixing gasket 105. The first helmet fixing knob 104 is arranged at the top of the treatment helmet 1 (i.e., the intersection of the curved first scale 102 and the curved second scale 103), and the knob part of the first helmet fixing knob 104 (the knob part is for people to rotate the knob manually) is located outside the treatment helmet 1, and the free end is located inside the treatment helmet 1, and the first helmet fixing gasket 105 is arranged at the free end of the first helmet fixing knob 104. The shape of the first helmet fixing knob 104 can be similar to that of a screw.

[0065] The treatment helmet 1 also includes a second helmet fixing knob 106 and a second helmet fixing gasket 107. The second helmet fixing knob 106 is disposed on the side of the treatment helmet 1, with the knob portion of the second helmet fixing knob 106 located outside the treatment helmet 1 and the free end located inside the treatment helmet 1. The second helmet fixing gasket 107 is disposed at the free end of the second helmet fixing knob 1. Similarly, the helmet fixing assembly formed by the combination of the second helmet fixing knob 106 and the second helmet fixing gasket 107 is provided in several groups (e.g., three groups), which are respectively arranged at equal intervals in the transverse direction on the side of the treatment helmet 1. Specifically, they can be arranged at equal intervals on the head circumference ring 101. More specifically, the several groups of helmet fixing gaskets arranged on the head circumference ring 101 can form a gasket ring inside the head circumference ring 101. In addition, the first helmet fixing gasket 105 and the second helmet fixing gasket 107 are both made of flexible materials to enhance the patient's comfort when wearing the treatment helmet 1.

[0066] When the doctor puts on the treatment helmet for the wearer, he can rotate the helmet fixing knobs on various positions of the treatment helmet to make the helmet fixing gaskets on various positions counteract the wearer's head to fix the treatment helmet on the wearer's head. Because the wearer may turn his head and other movements during treatment, the position of the treatment helmet may change, which may cause the actual stimulated position to change and affect the treatment effect. This situation can be avoided by cooperating with the helmet fixing knobs and helmet fixing gaskets.

[0067] Further, regarding the annular telescopic positioning component 2: The annular telescopic positioning assembly 2 includes a first annular telescopic positioning shaft 201, a second annular telescopic positioning shaft 202, a first positioning fastener 203 and a second positioning fastener 204. The first annular telescopic positioning shaft 201 and the second annular telescopic positioning shaft 202 are arranged parallel to each other and are located in the track of the curved first scale 102 and the curved second scale 103 of the treatment helmet 1. The first positioning fastener 203 is arranged in the track of the curved second scale 103 along with the first annular telescopic positioning shaft 201, and the second positioning fastener 204 is arranged in the track of the curved second scale 103 along with the second annular telescopic positioning shaft 202, that is, the first annular telescopic positioning shaft 201 and the second annular telescopic positioning shaft 202 can both be arranged along the curved first scale 102 and the curved second scale 103. Track movement, thereby achieving up and down movement along the longitudinal direction of the treatment helmet 1, and the first positioning fastener 203 will move on the track with the first annular telescopic positioning shaft 201, and the second positioning fastener 204 will move on the track with the second annular telescopic positioning shaft 202. When the doctor uses the first annular telescopic positioning shaft 201 and the second annular telescopic positioning shaft 202 to position the stimulation area, the first positioning fastener 203 can be used to fix the first annular telescopic positioning shaft 201 on the curved second scale 103, and the second positioning fastener 204 can be used to fix the second annular telescopic positioning shaft 202 on the curved second scale 103. The first positioning fastener 203 and the second positioning fastener 204 can be knobs, and the annular telescopic positioning shafts are fixed to the scale by rotating and squeezing.

[0068] The physician can accurately locate the area to be stimulated on the wearer's head by sliding the first annular telescopic positioning axis 201 and the second annular telescopic positioning axis 202 along the tracks of the curved first scale 102 and the curved second scale 103 on the treatment helmet 1, and fixing the first annular telescopic positioning axis 201 and the second annular telescopic positioning axis 202 with the first positioning fastener 203 and the second positioning fastener 204, and then connecting the first TMS stimulation beat and the second TMS stimulation beat to the first annular telescopic positioning axis 201 and / or the second annular telescopic positioning axis 202.

[0069] The transcranial magnetic stimulation device provided by the present invention can, when in use, first fix the treatment helmet to the head of a patient with spinocerebellar ataxia by using a helmet fixing knob and a helmet fixing gasket in combination. The physician can slide the first annular telescopic positioning axis and the second annular telescopic positioning axis along the tracks of the first ruler and the second ruler on the treatment helmet according to the head shape of each patient, and use the first positioning fastener and the second positioning fastener to fix the first annular telescopic positioning axis and the second annular telescopic positioning axis, thereby accurately locating the cerebellar hemisphere and the motor cortex M1 area of ​​the wearer's head, and recording the precise position of the area to be stimulated for the patient for the next treatment. The first TMS stimulation beat and the second TMS stimulation beat are then detachably connected to the corresponding area to be stimulated, and the first TMS stimulation beat and the second TMS stimulation beat are used to perform double-beat transcranial magnetic stimulation on the patient, which can fully activate the patient's brain area motor circuit and greatly improve the treatment efficiency and quality.

[0070] Spinocerebellar ataxia (SCA) is an autosomal dominant disorder characterized by progressive impairment of balance and coordination, often manifesting as gait ataxia, movement disorders, and dysarthria. Some subtypes exhibit phenotypic heterogeneity and may be associated with pyramidal and extrapyramidal lesions, peripheral neuropathy, and optic atrophy. Currently, there is no specific treatment for SCA, and clinical management primarily relies on symptomatic supportive care.

[0071] See also Figure 3 In this example, 3 SCA patients were collected from the neurology clinic of Peking Union Medical College Hospital between July and December 2024, and all patients signed informed consent. Figure 1 The transcranial magnetic stimulation device shown (wherein the first TMS stimulation beat is a circular coil and the second TMS stimulation beat is a conical coil) performs dual-beat stimulation. The treatment plan in this embodiment has been approved by the internal ethics review of Peking Union Medical College Hospital.

[0072] First, the patient's resting motor threshold (RMT) can be measured. Before measuring the RMT, the patient undergoes a 5T MRI scan of the head and a patient head model is imported into the software. With the patient in a seated position, the thumb motor cortex (M1) on the dominant hand (if the patient is right-handed, the left M1 area is stimulated) is stimulated using a single pulse pattern. Ten stimulations are administered, with five of these stimuli eliciting movement of the thumb abductor muscle (elicited evoked potentials exceeding 50 mV). This stimulation intensity is considered the RMT. After every ten stimulations, the RMT is re-measured.

[0073] In this embodiment, the stimulation scheme for the patient is: Location: left motor cortex M1 hand area and cerebellar vermis; Magnetic stimulation coils: a circular coil was used for the left motor cortex M1 hand area, and a conical coil was used for the cerebellar vermis; Stimulation parameters: Circular coil: Frequency: 10 Hz; Strength: 100% RMT; Sequence: 100, 10 times / sequence; Interval: 10s (10-25s).

[0074] Conical coil: Frequency: 10Hz; Strength: 120% RMT; Sequence: 20, 50 times / sequence; Interval: 25s (10-25s); Stimulation time: Stimulation is performed once in the morning and once in the afternoon every day for 10 consecutive days.

[0075] Before and after stimulation, patients were evaluated with scales, including: (1) Assessment of cognitive changes: Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA); (2) Assessment of mood changes: SAS, SDS; (3) Assessment of ataxia: Ataxia Assessment and Rating Scale (SARA), International Cooperative Ataxia Rating Scale (ICARS); (4) Assessment of sleep changes: RBDSQ; (5) Assessment of walking changes: 10m walk test, gait analysis system.

[0076] (1) Cognitive changes: MMSE and MoCA scores increased after treatment; (2) Mood changes: SAS scores showed that anxiety levels decreased after treatment, indicating that treatment may have a positive effect on alleviating anxiety. SDS scores were relatively stable with little change, indicating that depression did not improve significantly.

[0077] (3) Changes in ataxia: ICARS and SARA scores showed a decrease before and after treatment, indicating that the patients had a certain degree of improvement in ataxia.

[0078] (4) Changes in sleep: The score decreased slightly after treatment, indicating that the sleep condition has partially improved.

[0079] (5) Changes in walking condition: After treatment, the walking speed and stride length increased slightly, especially the stride length, which showed a significant improvement in walking condition.

[0080] The above results demonstrate that the multi-target transcranial magnetic stimulation device provided in this example has a positive therapeutic effect on patients, fully demonstrating the potential value of TMS in the treatment of SCA. Specifically, this example demonstrates that TMS can improve motor coordination and balance in SCA patients by modulating the function of the cerebellar-thalamic-cortical circuit. In particular, repetitive transcranial magnetic stimulation of the cerebellum and motor cortex can effectively improve patients' ataxia symptoms, gait instability, and fine motor impairments. Furthermore, TMS can comprehensively improve neurological function in SCA patients by promoting neuroplasticity, regulating neurotransmitter balance, and increasing cerebral blood flow.

[0081] The following provides a method for utilizing a multi-target transcranial magnetic stimulation device (e.g., Figure 1 The treatment plan in this embodiment has been approved by the internal ethics review of Peking Union Medical College Hospital.

[0082] Example 2: Multi-target TMS stimulation therapy was performed on patients with Alzheimer's disease using a multi-target TMS device. The treatment plan and the types of the first TMS stimulation beat and the second TMS stimulation beat used are shown in Table 1.

[0083] Table 1

[0084] The corresponding patient types for the above different schemes are shown in Table 2.

[0085] Table 2

[0086] Implementation Case 3: Utilization Figure 1 The multi-target transcranial magnetic stimulation device shown was used to perform multi-target stimulation treatment on ALS patients. The treatment plan and the types of the first TMS stimulation beat and the second stimulation beat used are shown in Table 3.

[0087] Because most ALS patients have cortical hyperexcitation, and clinically some ALS patients have also been found to have cortical excitation inhibition, RMT and MEP evoked potential tests should be performed before treatment to determine the specific treatment plan.

[0088] Table 3

[0089] The multi-target transcranial magnetic stimulation neural regulation system provided by the present invention is described below. The multi-target transcranial magnetic stimulation system described below is implemented based on the multi-target transcranial magnetic stimulation device described above.

[0090] See also Figure 4The present invention provides a multi-target transcranial magnetic stimulation neural regulation system, which may include: Control terminal: used for setting a stimulation scheme and sending stimulation instructions to the stimulation signal generating module, wherein the stimulation scheme is determined based on the position data of the brain area to be stimulated of the subject input by the user; The stimulation signal generating module is used to: respond to the stimulation instruction issued by the control terminal to cause the first TMS stimulation beat and the second TMS stimulation beat located in the area to be stimulated to generate magnetic stimulation according to the stimulation scheme set in the stimulation instruction.

[0091] After the patient wears the treatment helmet, the doctor can use the annular telescopic positioning component to locate the area to be stimulated and obtain the position data of the area to be stimulated, and then input the position data of the area to be stimulated into the multi-target transcranial magnetic stimulation neuroregulation system to record the position data of the area to be stimulated of the patient for use in the next treatment. After the doctor completes the positioning of the area to be stimulated and connects the stimulation beat to the treatment helmet, he can send a stimulation instruction to the stimulation signal generating module through the control terminal. The stimulation signal generating module responds to the stimulation instruction issued by the control terminal to cause the first TMS stimulation beat and the second TMS stimulation beat located in the area to be stimulated to generate magnetic stimulation according to the stimulation scheme set in the stimulation instruction, thereby realizing multi-target transcranial magnetic stimulation neuroregulation of the patient.

[0092] Figure 5 The following is a schematic diagram of the physical structure of an electronic device based on the multi-target transcranial magnetic stimulation device described above. Figure 5 As shown, the electronic device may include: a processor 810, a communication interface 820, a memory 830, and a communication bus 840, wherein the processor 810, the communication interface 820, and the memory 830 communicate with each other via the communication bus 840. The processor 810 may call the logic instructions in the memory 830 to perform the following steps: Receiving the position data of the area to be stimulated obtained by the physician using the annular telescopic positioning component to locate the area to be stimulated after the patient wears the treatment helmet; The first TMS stimulation beat and the second TMS stimulation beat corresponding to the area to be stimulated are magnetically stimulated according to the stimulation plan.

[0093] Further, the logic instructions in the memory 830 described above can be implemented in the form of software functional units and sold or used as independent products, and can be stored in a computer readable storage medium. Based on such understanding, the technical solutions of the present application essentially or the parts that make contributions to the prior art or parts of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a storage medium, and includes a number of instructions for causing a computer device (which can be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present application. The aforementioned storage medium includes: a U disk, a mobile hard disk, a read-only memory (ROM, Read-Only Memory), a random access memory (RAM, Random Access Memory), a magnetic disk or an optical disk, and various media that can store program codes.

[0094] In another aspect, the present application also provides a computer program product based on the multi-target transcranial magnetic stimulation device described above, the computer program product comprising a computer program, the computer program being stored on a non-transitory computer readable storage medium, and the computer program being executable by a processor to cause a computer to perform the following steps: receiving position data of the to-be-stimulated region obtained by the doctor using the annular telescopic positioning assembly to position the to-be-stimulated region after the subject wears the treatment helmet; causing the first TMS stimulation pulse and the second TMS stimulation pulse corresponding to the to-be-stimulated region to generate magnetic stimulation according to the stimulation scheme.

[0095] In another aspect, the present application also provides a non-transitory computer readable storage medium based on the multi-target transcranial magnetic stimulation device described above, the non-transitory computer readable storage medium storing a computer program, and the computer program being executable by a processor to cause a computer to perform the following steps: receiving position data of the to-be-stimulated region obtained by the doctor using the annular telescopic positioning assembly to position the to-be-stimulated region after the subject wears the treatment helmet; causing the first TMS stimulation pulse and the second TMS stimulation pulse corresponding to the to-be-stimulated region to generate magnetic stimulation according to the stimulation scheme.

[0096] The device embodiments described above are only schematic, and the units described as separate components can or can not be physically separated, and the components shown as units can or can not be physical units, i.e., they can be located in one place, or distributed on multiple network units. Part or all of the modules can be selected according to actual needs to achieve the purpose of the present embodiment. Those skilled in the art can understand and implement without creative labor.

[0097] Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented using software plus a necessary general-purpose hardware platform, or of course, hardware. Based on this understanding, the essence of the above technical solution, or the portion that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, or an optical disk, and includes a number of instructions for causing a computer device (such as a personal computer, server, or network device) to execute the methods described in each embodiment or certain portions of the embodiments.

[0098] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A multi-target transcranial magnetic stimulation device, characterized in that: include: It includes a treatment helmet, an annular telescopic positioning component, a first TMS stimulation racket, and a second TMS stimulation racket. The annular telescopic positioning component is arranged on the treatment helmet and can move up and down along the longitudinal direction of the treatment helmet. The first TMS stimulation racket and the second TMS stimulation racket can be detachably connected to the annular telescopic positioning component respectively.

2. The multi-target transcranial magnetic stimulation device according to claim 1, characterized in that: The annular telescopic positioning assembly includes a first annular telescopic positioning shaft and a first positioning fastener. The first annular telescopic positioning shaft can move up and down along the longitudinal direction of the treatment helmet, and the first positioning fastener is used to fix the first annular telescopic positioning shaft on the treatment helmet. The first TMS stimulation rack and the second TMS stimulation rack can be detachably connected to the first annular telescopic positioning shaft respectively.

3. The multi-target transcranial magnetic stimulation device according to claim 2, characterized in that: The annular telescopic positioning assembly also includes a second annular telescopic positioning shaft and a second positioning fastener. The second annular telescopic positioning shaft is arranged parallel to the first annular telescopic positioning shaft, and the second annular telescopic positioning shaft can also move up and down along the longitudinal direction of the treatment helmet. The second positioning fastener is used to fix the second annular telescopic positioning shaft on the treatment helmet. The first TMS stimulation rack and the second TMS stimulation rack can be detachably connected to the second annular telescopic positioning shaft respectively.

4. The multi-target transcranial magnetic stimulation device according to any one of claims 1 to 3, characterized in that: The treatment helmet includes a head ring and a curved first ruler, wherein the curved first ruler is arranged on the head ring and forms an internal space capable of accommodating the patient's head together with the head ring, and the annular telescopic positioning assembly is arranged on the curved first ruler and can move up and down along the curved first ruler; The treatment helmet further comprises a curved second ruler, which is arranged on the head circumference ring and intersects with the curved first ruler in a cross shape.

5. The multi-target transcranial magnetic stimulation device according to claim 4, characterized in that: The curved first scale and / or the curved second scale are provided with a track along the curved direction thereof, so that the annular telescopic positioning assembly can move up and down along the curved first scale and / or the curved second scale.

6. The multi-target transcranial magnetic stimulation device according to any one of claims 1 to 3, characterized in that: The treatment helmet includes a first helmet fixing knob and a first helmet fixing gasket. The first helmet fixing knob is arranged on the top of the treatment helmet, and the knob part of the first helmet fixing knob is located outside the treatment helmet, and the free end is located inside the treatment helmet. The first helmet fixing gasket is arranged at the free end of the first helmet fixing knob.

7. The multi-target transcranial magnetic stimulation device according to claim 6, characterized in that: The treatment helmet includes a second helmet fixing knob and a second helmet fixing gasket, wherein the second helmet fixing knob is arranged on the side of the treatment helmet, the knob portion of the second helmet fixing knob is located outside the treatment helmet, and the free end is located inside the treatment helmet, and the second helmet fixing gasket is arranged at the free end of the second helmet fixing knob; A plurality of helmet fixing assemblies formed by the second helmet fixing knobs and the second helmet fixing gaskets are provided and are equidistantly arranged on the side surfaces of the treatment helmet in the transverse direction.

8. The multi-target transcranial magnetic stimulation device according to any one of claims 1 to 3, characterized in that: It also includes a load-bearing rod, and the treatment helmet and the load-bearing rod are detachably connected and can move relatively.

9. A multi-target transcranial magnetic stimulation neural regulation system implemented based on the multi-target transcranial magnetic stimulation device according to any one of claims 1 to 8, characterized in that: include: Control terminal: used for setting a stimulation scheme and sending stimulation instructions to the stimulation signal generating module, wherein the stimulation scheme is determined based on the position data of the brain area to be stimulated of the subject input by the user; The stimulation signal generating module is used to: respond to the stimulation instruction issued by the control terminal to cause the first TMS stimulation beat and the second TMS stimulation beat located in the area to be stimulated to generate magnetic stimulation according to the stimulation scheme set in the stimulation instruction.

10. The multi-target transcranial magnetic stimulation neural regulation system according to claim 9, characterized in that: The multi-target transcranial magnetic stimulation neuroregulatory system is used to treat any of the following diseases or functional disorders of the subject: neurodegenerative diseases, mental disorders, cognitive dysfunction, movement disorders, sensory disorders, pain-related diseases, sequelae of stroke, sequelae of brain trauma, neurodevelopmental disorders, sleep disorders, drug addiction and other nervous system-related diseases.

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