Composition with instant soothing effect and application

Abstract

The invention discloses a composition with soothing and repairing effects, the composition is prepared from the following components in parts by weight: 0.01-0.1 part of a helichrysum italicum extract, 0.01-1 part of an inonotus obliquus extract and 0.01-5 parts of a rhodiola rosea root extract.The composition provided by the invention is natural and non-irritant, and has the effects of rapidly soothing and fading red and the like; on the other hand, the problems of redness, swelling, pain, itching and the like after skin stimulation can be effectively relieved, the skin barrier defense capability is improved, the requirements of modern people for safety, high efficiency, economy and the like are met, and good application prospects are achieved.

Description

TECHNICAL FIELD

[0001] The application discloses a composition with instant soothing effect, in particular, a composition with instant soothing effect and application, and belongs to the technical field of cosmetics. BACKGROUND

[0002] Skin sensitivity refers to high skin reactivity, poor tolerance and even easy allergy. It is manifested in subjective symptoms such as itching, stinging and burning, and objective symptoms such as redness and swelling. In recent years, due to environmental factors, diseases, endocrine disorders, nutritional conditions, mental factors and improper care leading to weakening of skin barrier function, the number of people with sensitive skin has increased year by year. With the improvement of people's living standards, functional cosmetics are more and more widely used, and functional ingredients in cosmetics are also easy to cause skin allergy. Therefore, skin care products designed for sensitive skin are increasingly attracting attention.

[0003] At present, it is generally believed that the occurrence of sensitive skin is a complex process involving skin barrier-nerve blood vessel-immune inflammation. Therefore, to solve the problem of skin sensitivity, we can start from repairing damaged barrier, anti-inflammatory and other aspects, and pay attention to the safety of raw materials and the reduction of allergens in the formulation design process. The damaged barrier function of sensitive skin needs a long time to repair to restore the skin to a healthy state, but in this process, the acute sensory discomfort symptoms caused by high nerve reactivity and high skin inflammation level need to be quickly relieved in a short time, which is the most core demand of sensitive skin. At present, most of the products on the market for solving skin sensitivity can only moisturize and soothe the skin after being sensitive, some of which rely on the moisturizing ingredients to relieve the symptoms of sensitive skin, and some of which even add hormone ingredients, and there are very few products that can quickly soothe and fade red.

[0004] At present, it is generally believed that the occurrence of sensitive skin is a complex process involving skin barrier-nerve blood vessel-immune inflammation. Therefore, to solve the problem of skin sensitivity, we can start from repairing damaged barrier, anti-inflammatory and other aspects, and pay attention to the safety of raw materials and the reduction of allergens in the formulation design process. The damaged barrier function of sensitive skin needs a long time to repair to restore the skin to a healthy state, but in this process, the acute sensory discomfort symptoms caused by high nerve reactivity and high skin inflammation level need to be quickly relieved in a short time, which is the most core demand of sensitive skin. At present, most of the products on the market for solving skin sensitivity can only moisturize and soothe the skin after being sensitive, some of which rely on the moisturizing ingredients to relieve the symptoms of sensitive skin, and some of which even add hormone ingredients, and there are very few products that can quickly soothe and fade red.

[0005] In summary, it is necessary to develop a product that can quickly soothe and fade red, and the market demand for instant soothing and repairing cosmetics is huge. SUMMARY

[0006] In view of the above problems, the purpose of the present application is to provide a composition with soothing and repairing effect and safe and stable application in cosmetics.

[0007] To this end, the first technical solution provided by the present application is as follows:

[0008] A composition with instant soothing effect, comprising the following components in parts by weight: Italian wax chrysanthemum extract 0.01-0.1 parts, birch brown fungus extract 0.01-1 parts, rhodiola root extract 0.01-5 parts.

[0009] Further, the composition further comprises sunflower bud extract 0.001-0.1 parts.

[0010] Further, the composition further comprises Aureobasidium pullulans fermentation product 0.1-10 parts.

[0011] Further, the composition further comprises Lactobacillus / soybean milk fermentation product filtrate 0.1-5 parts.

[0012] Further, the composition further comprises D-panthenol 0.1-5 parts.

[0013] Further, the composition is composed of the following components in parts by weight: Italian wax chrysanthemum extract 0.01-0.1 parts, birch brown fungus extract 0.01-1 parts, rhodiola root extract 0.01-5 parts, sunflower bud extract 0.001-0.1 parts, Aureobasidium pullulans fermentation product 0.1-10 parts, Lactobacillus / soybean milk fermentation product filtrate 0.1-5 parts, and D-panthenol 0.1-5 parts.

[0014] Further, the composition is composed of the following components in parts by weight: Italian wax chrysanthemum extract 0.01-0.1 parts, birch brown fungus extract 0.01-1 parts, rhodiola root extract 0.01-5 parts, sunflower bud extract 0.001-0.1 parts, Aureobasidium pullulans fermentation product 0.1-10 parts, Lactobacillus / soybean milk fermentation product filtrate 0.1-5 parts, and D-panthenol 0.1-5 parts.

[0015] The second technical solution provided by the present application is the use of the above-mentioned composition, which is applied to cosmetics, and the cosmetics are one or more of cosmetic water, emulsion, essence, cream, and mask.

[0016] Further, the addition amount of the composition in the cosmetic is 0.1-20% of the total weight of the cosmetic.

[0017] Further, the addition amount of the composition in the cosmetic is 0.5-15% of the total weight of the cosmetic.

[0018] Compared with the prior art, the present application has the following beneficial effects:

[0019] 1. The composition provided by the present application can provide rapid soothing and redness-reducing effects in a short time by compounding Italian wax chrysanthemum extract, birch polypore extract, rhodiola root extract, sunflower bud extract and fermentation product of Aureobasidium pullulans.

[0020] 2. The Italian wax chrysanthemum extract in the composition provided by the present application can promote the synthesis and release of nerve endings in the dermis and epidermis and release molecules with soothing and relaxing functions, β-endorphin, to quickly reduce pain, and can effectively prevent and reduce inflammation by reducing the release of three activators, PGE2, TNFα and histamine; the birch polypore extract helps to reduce pro-inflammatory mediators IL-8 and IL-6 and has a calming effect on skin redness; the rhodiola root extract is a traditional Chinese medicine ingredient that can play an adaptogen role, can reduce cutaneous neurogenic inflammation, reduce the release of histamine, P substance and the like, and can effectively inhibit the expression of the TRPV1 gene induced by capsaicin, thereby relieving adverse subjective feelings such as burning and stinging caused by overactive TRPV1; the sunflower bud extract and the fermentation product of Aureobasidium pullulans can promote the production of NAD+ of the skin itself, and are crucial for cell damage and energy repair caused by harmful factors such as ultraviolet rays, can revitalize the skin and improve the skin barrier defense ability.

[0021] 3. The composition provided by the present application is not only mild and safe, but also has the effect of soothing sensitive skin, meets the requirements of modern people for safety, high efficiency and economy and the like, and has a good application prospect. DETAILED DESCRIPTION

[0022] The claims of the present application are further described in detail in combination with specific embodiments, but do not constitute any limitation on the present application, and any limited number of modifications made by anyone within the scope of protection of the claims of the present application is still within the scope of protection of the claims of the present application.

[0023] Example 1

[0024] The composition provided by the present application has instant soothing effect, which is composed of the following components by weight: Italian wax chrysanthemum extract 0.02 g, birch polypore extract 0.30 g, rhodiola root extract 2.00 g, sunflower bud extract 0.03 g, fermentation product of Aureobasidium pullulans 4.00 g, filtrate of lactobacillus / soybean milk fermentation product 0.10 g and D-panthenol 0.50 g.

[0025] Example 2

[0026] The composition with instant soothing effect provided by the present application is composed of the following components in the following amounts: 0.02 g of Italian wax chrysanthemum extract, 0.60 g of birch polypore extract, 1.00 g of rhodiola root extract, 0.001 g of sunflower bud extract, 0.10 g of Aureobasidium pullulans fermentation product, 0.10 g of lactobacillus / soybean milk fermentation product filtrate, and 0.50 g of D-panthenol.

[0027] Example 3

[0028] The composition with instant soothing effect provided by the present application is composed of the following components in the following amounts: 0.02 g of Italian wax chrysanthemum extract, 0.30 g of birch polypore extract, 2.00 g of rhodiola root extract, 0.06 g of sunflower bud extract, 8.00 g of Aureobasidium pullulans fermentation product, 0.10 g of lactobacillus / soybean milk fermentation product filtrate, and 0.50 g of D-panthenol.

[0029] Comparative Example 1

[0030] In comparison with Example 1, the Italian wax chrysanthemum extract, birch polypore extract, and sunflower bud extract are removed, and the other components are the same.

[0031] Comparative Example 2

[0032] In comparison with Example 1, the rhodiola root extract and Aureobasidium pullulans fermentation product are removed, and the other components are the same.

[0033] Comparative Example 3

[0034] In comparison with Example 1, the Italian wax chrysanthemum extract, birch polypore extract, and rhodiola root extract are removed, and the other components are the same.

[0035] The examples and comparative examples of the soothing composition provided by the present application are shown in Table 1 below.

[0036] Table 1, ingredient table of examples and comparative examples

[0037]

[0038] In order to better prove the technical solutions provided by the present application, the following gives the detection test of the technical solutions provided by the present application:

[0039] 1. Cell soothing effect test

[0040] 1.1 Test method

[0041] Mouse macrophage cell lines are cultured in vitro, and the sample to be tested is added to the cells for testing. First, the cytotoxicity of the sample is tested, and then a concentration without cytotoxicity is selected for the cell soothing test, and the soothing effect of the sample is analyzed and evaluated by statistical means.

[0042] The cell soothing test comprises two:

[0043] NO release test: after the test sample is diluted with LPS-containing cell culture medium to a non-cytotoxic concentration, the sample is added, LPS-containing culture medium is used as a negative control (NC), and LPS-free cell culture medium is used as a blank control (BC). After the sample is added, the cells are continuously cultured for 20-24 h. After the action ends, 50 μl of the culture solution is taken and placed in a new cell plate. An equal volume of Griess reagent is added, mixed thoroughly, and reacted in the dark for 10 min. The OD value is detected at 540 nm.

[0044] IL-6 inflammatory factor test: after the test sample is diluted with LPS-containing cell culture medium to a non-cytotoxic concentration, the sample is added, LPS-containing culture medium is used as a negative control (NC), and LPS-free cell culture medium is used as a blank control (BC). After the sample is added, the cells are continuously cultured for 20-24 h. After the action ends, the supernatant is taken and tested according to the operation rules of the IL-6 Elisa kit.

[0045] According to the test results, when the relative content of NO in the blank control group (NC group) is ≤50%, the test is valid. Statistical and significance analysis is performed using GraphPad Prism software, and the P value is calculated. P<0.05 indicates a significant difference. When P<0.05 and the NO inhibition rate is ≥10% or the IL-6 inhibition rate is ≥10%, it is determined that the sample has soothing efficacy; otherwise, it is determined that the sample has no soothing efficacy.

[0046] 1.2 Test results

[0047] Table 2, soothing efficacy test results

[0048] Sample name NO inhibition rate (%) IL6 inhibition rate (%) P value Relieving effect Example 1 96.35 92.23 P＜0.05 Yes Example 2 78.85 75.85 P＜0.05 Yes Example 3 85.52 86.52 P＜0.05 Yes Comparative Example 1 2.58 6.59 P＞0.05 No Comparative Example 2 5.67 8.09 P＞0.05 No Comparative Example 3 3.04 -4.29 P＞0.05 No

[0049] As can be seen from the experimental results in Table 2, the cells of Examples 1, 2 and 3 have good soothing efficacy, indicating that the plant extract combination prepared by the present application has good soothing efficacy on the skin.

[0050] 2. Stability test

[0051] 2.1 Test method:

[0052] Room temperature (light shielding): the test sample is placed at room temperature (light shielding), and the sample change is observed;

[0053] Cold resistance (5℃): the test sample is placed in a 5℃ incubator for low-temperature testing, and the sample change is observed;

[0054] Cold resistance (-15℃): the test sample is placed in a -15℃ incubator for low-temperature testing, and the sample change is observed;

[0055] Heat resistance (45℃): The test sample was placed in a 45℃ incubator for high temperature test, and the sample change was observed;

[0056] Light (north light): The test sample was placed in the north light for observation of sample change;

[0057] Cold and heat cycle: The test sample was placed in a-15℃ / 45℃ high and low temperature alternating incubator for cold and heat cycle test, 6 days cycle once, and the sample change was observed.

[0058] 2.2, the test results are shown in Table 3 ("√" represents no abnormality)

[0059] Table 3, stability test result table

[0060] Group Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 3 Room temperature (avoid light) √ √ √ √ √ √ Cold resistance (5℃) √ √ √ √ √ √ Cold resistance (-15℃) √ √ √ √ √ √ Heat resistance (45℃) 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish Light (north light) 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish Cold and heat cycle 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish 90 days yellowish Conclusion More stable More stable More stable More stable More stable More stable

[0061] From the experimental results in Table 3, it can be seen that the stability of Examples 1-3 and Comparative Examples 1-3 has no obvious abnormality, and the stability is passed.

[0062] 3, human instant soothing efficacy test

[0063] 3.1, test method

[0064] 80 volunteers (18-60 years old) with dry skin and sensitive to lactic acid were selected, and filter paper pieces (diameter about 0.8 cm) soaked with 50 μL of 10% lactic acid solution were applied to both sides of the nasolabial groove of the volunteers at the same time; when the lactic acid stinging score is ≥3 (moderate), it is considered as lactic acid stinging positive and is included in the test. After the completion of lactic acid stinging, the filter paper was removed, and 10% diluted aqueous solution of Examples 1-3 or Comparative Examples 1-3 was randomly applied to one side of the nasolabial groove, and the other side was not treated, and the amount of sample applied was 0.1 mL. The lactic acid stinging score (0-20 points) was evaluated at 0 min, 0.5 min, 2.5 min, 5 min, 7.5 min, 15 min and 30 min after the sample was used. The stronger the discomfort, the higher the score; finally, the total scores of the sample area and the blank area were compared.

[0065] The statistical analysis software is SPSS, and the Shapiro-Wilk Test is used for significance test of normal distribution of data improvement value. If Sig. (two-sided) > 0.01, it is normally distributed, and paired t test is performed. If Sig. (two-sided) < 0.01, it is not normally distributed, and Wilcoxon test is performed.

[0066] If P>0.05, it means no significant difference, recorded as "n.s."; if P<0.05, it means significant difference, and 0.01≤P<0.05, recorded as "*"; 0.001≤P<0.01, recorded as "**"; P<0.001, recorded as "***". If the results are improved and P<0.05, it means effective, recorded as "√"; if the results are improved but P>0.05 or P<0.05 but the results are worse, it means ineffective, recorded as "×".

[0067] 3.2, Test results

[0068] In this project, 60 people were screened and finally 60 people completed the test.

[0069] Table 4, Human instant soothing efficacy test results

[0070]

[0071]

[0072] As can be seen from the experimental results in Table 4, after the lactic acid stinging, the stinging score of the sample area coated with Examples 1-3 was significantly different from that of the blank area (P<0.05), indicating that the test sample had the effect of soothing lactic acid stinging, i.e. the samples of Examples 1-3 had good human instant soothing efficacy.

[0073] 4, Consumer use test

[0074] 4.1, Test method

[0075] 30 consumers were selected and divided into three groups, each group of 10 people used a single random side to add 2.5% of the essence of Examples 1 or 2 or 3, while the other side used the essence added with 2.5% of Comparative Examples 1 or 2 or 3. And according to the time, the sample was evaluated by answering the specified questions, the number of people giving positive feedback was counted as the proportion of the total number of evaluators, and the overall satisfaction of the subjects to the problem was understood. If the satisfaction of the subjects to the problem is more than 50%, it means that the test sample has corresponding efficacy.

[0076] 4.2, Test results

[0077] The results of filling out the questionnaire are as follows:

[0078] Pre-use questionnaire:

[0079] (1) 100% of the subjects had sensitive red skin.

[0080] Post-use 10min questionnaire:

[0081] (1) After using the product for 10min, an average of 99.63% of the subjects thought that Examples 1-3 were mild and non-irritating;

[0082] (2) After 10 minutes of use, 94.28% of the subjects on average found the soothing effect of Example 1-3 to be good;

[0083] (3) After 10 minutes of use, 98.95% of the subjects on average found the redness reduction effect of Example 1-3 to be good;

[0084] (4) After 10 minutes of use, 49.23% of the subjects on average found Comparative Example 1-3 to be mild and non-irritating;

[0085] (5) After 10 minutes of use, 43.15% of the subjects on average found Comparative Example 1-3 to have a good soothing effect;

[0086] (6) After 10 minutes of use, 33.91% of the subjects on average found Comparative Example 1-3 to have a good redness reduction effect.

[0087] Post-use 30 minute questionnaire:

[0088] (1) After 30 minutes of use, 96.83% of the subjects on average found Example 1-3 to be mild and non-irritating;

[0089] (2) After 30 minutes of use, 85.67% of the subjects on average found Example 1-3 to have a good soothing effect;

[0090] (3) After 30 minutes of use, 95.32% of the subjects on average found Example 1-3 to have a good redness reduction effect;

[0091] (4) After 30 minutes of use, 40.82% of the subjects on average found Comparative Example 1-3 to be mild and non-irritating;

[0092] (5) After 30 minutes of use, 40.26% of the subjects on average found Comparative Example 1-3 to have a good soothing effect;

[0093] (6) After 30 minutes of use, 25.22% of the subjects on average found Comparative Example 1-3 to have a good redness reduction effect.

[0094] The consumer use test results show that Example 1-3 samples are mild and non-irritating, while having a relatively good fast soothing redness reduction efficacy relative to Comparative Example 1-3.

[0095] To sum up, the plant components are researched in the cosmetic technology field, and the composition is prepared through reasonable and scientific proportioning, has natural non-irritation, rapid soothing and red fading effects, can effectively relieve the problems of redness, swelling, pain and itching after the skin is stimulated, improves the skin barrier defense ability, and can effectively play the effect of instant soothing sensitive skin when applied in cosmetics.

[0096] The above embodiment is the preferred embodiment of the present application, but the embodiment of the present application is not limited to the above embodiment, and any change, modification, substitution, combination, simplification made without departing from the spirit and principle of the present application should be an equivalent replacement mode, and all are included in the protection scope of the present application.

Claims

1. A composition with immediate soothing effect, characterized in that The composition comprises the following components in parts by weight: 0.01-0.1 parts of Helichrysum italiensis extract, 0.01-1 parts of Inonotus obliquus extract, and 0.01-5 parts of Rhodiola rosea root extract.

2. The composition according to claim 1, characterized in that The composition further comprises 0.001-0.1 parts of sunflower sprout extract.

3. The composition according to claim 1, characterized in that The composition further comprises 0.1-10 parts of a fermentation product of Aureobasidium pullulans.

4. The composition according to claim 1, characterized in that The composition further comprises 0.1-5 parts of lactobacillus / soy milk fermentation product filtrate.

5. The composition according to claim 1, characterized in that The composition further comprises 0.1-5 parts of D-panthenol.

6. The composition according to claim 1, characterized in that The composition consists of the following components in parts by weight: 0.01-0.1 parts of Helichrysum italiensis extract, 0.01-1 parts of Inonotus obliquus extract, 0.01-5 parts of Rhodiola rosea root extract, 0.1-5 parts of lactobacillus / soy milk fermentation product filtrate and 0.1-5 parts of D-panthenol.

7. The composition according to claim 1, characterized in that The composition consists of the following components in parts by weight: 0.01-0.1 parts of Helichrysum italiensis extract, 0.01-1 parts of Inonotus obliquus extract, 0.01-5 parts of Rhodiola rosea root extract, 0.001-0.1 parts of sunflower sprout extract, 0.1-10 parts of Aureobasidium pullulans fermentation product, 0.1-5 parts of lactobacillus / soy milk fermentation product filtrate, and 0.1-5 parts of D-panthenol.

8. Use of the composition according to any one of claims 1 to 7 in the preparation of cosmetics, characterized in that: The cosmetics are one or more of lotion, emulsion, essence, cream and facial mask.

9. The use according to claim 8, characterized in that The added amount of the composition in cosmetics is 0.1-20% of the total weight of the cosmetics.

10. The use according to claim 8, characterized in that The added amount of the composition in cosmetics is 0.5-15% of the total weight of the cosmetics.

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