Traditional Chinese medicine composition for reducing uric acid and protecting liver and preparation method thereof

Abstract

The embodiment of the invention discloses a traditional Chinese medicine composition for reducing uric acid and protecting the liver and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by weight: 1-6 parts of rhizoma atractylodis, 1-4 parts of rhizoma coptidis from Sichuan of China, 1-10 parts of sunflower head, 1-10 parts of malus toringoides leaf, 1-6 parts of Chinese starjasmine stem, 1-6 parts of sargentgloryvine stem, 1-10 parts of radix clematidis, 1-6 parts of piper wallichii, 1-4 parts of rhizoma corydalis and 1-6 parts of fructus liquidambaris. The traditional Chinese medicine composition disclosed by the invention is clinically verified to be capable of not only reducing uric acid, but also exerting the effects of resolving mass and resolving stagnation, removing dampness and eliminating phlegm, relieving arthralgia, clearing liver and benefiting gallbladder, and protecting liver. The traditional Chinese medicine composition adopts a drinking mode of brewing with boiled water, does not need a complicated decoction process, is convenient and quick, is suitable for the pace of life of modern people, and is easily accepted by patients. The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, does not contain any chemical synthesis component, has small side effects and high safety, and can be taken for a long time.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine technology, and specifically to a traditional Chinese medicine composition for lowering uric acid and protecting the liver and a preparation method thereof. Background Art

[0002] Hyperuricemia is a common metabolic disease. Long-term elevated uric acid levels can lead to complications such as gouty arthritis and kidney damage, severely impacting patients' quality of life. Furthermore, as a crucial metabolic organ in the human body, the liver's proper function is crucial for uric acid metabolism and overall health. Currently, numerous medications and products are available on the market for hyperuricemia and liver protection, but most suffer from significant side effects and short-lasting efficacy.

[0003] Traditional Chinese medicine (TCM) offers unique advantages in treating these conditions. Through rational formulation and preparation, it can exert multi-target, multi-pathway therapeutic effects with relatively minimal side effects. Therefore, developing a safe and effective TCM for lowering uric acid and protecting the liver is of great practical significance. Summary of the Invention

[0004] To this end, the present invention provides a Chinese medicine composition for lowering uric acid and protecting the liver and a preparation method thereof.

[0005] In order to achieve the above objectives, the embodiments of the present invention provide the following technical solutions:

[0006] According to a first aspect of an embodiment of the present invention, the present invention provides a traditional Chinese medicine composition for lowering uric acid and protecting the liver, wherein the traditional Chinese medicine composition comprises, by weight: 1-6 parts of Atractylodes lancea, 1-4 parts of Coptis chinensis, 1-10 parts of Helianthus annuus, 1-10 parts of Erse leaves, 1-6 parts of Trachelospermum schizandrae, 1-6 parts of Sargentodoxae, 1-10 parts of Clematis chinensis, 1-6 parts of Heather strychnos nux vomica, 1-4 parts of Corydalis yanhusuo, and 1-6 parts of Smilax glabra.

[0007] Furthermore, the Chinese medicine composition includes, by weight: 2 parts of Atractylodes lancea, 3 parts of Coptis chinensis, 8 parts of Helianthus annuus, 1 part of Oise leaves, 4 parts of Trachelospermum schizandrae, 2 parts of Sargentodoxae, 5 parts of Clematidis, 2 parts of Heather strychnos, 3 parts of Corydalis yanhusuo, and 2 parts of Smilax glabra.

[0008] Furthermore, the Chinese medicine composition includes, by weight: 4 parts of Atractylodes lancea, 1 part of Coptis chinensis, 5 parts of Helianthus annuus, 6 parts of Oise leaves, 6 parts of Trachelospermum schizandrae, 3 parts of Sargentodoxae, 1 part of Clematidis, 5 parts of Heather strychnos, 2 parts of Corydalis yanhusuo, and 3 parts of Smilax glabra.

[0009] Furthermore, the Chinese medicine composition includes, by weight: 1 part of Atractylodes lancea, 4 parts of Coptis chinensis, 2 parts of Helianthus annuus, 8 parts of Euphorbia cerifera, 2 parts of Trachelospermi schizandrae, 5 parts of Sargentodoxae cyperus, 3 parts of Clematidis, 6 parts of Heather strychnos nux vomica, 2 parts of Corydalis yanhusuo, and 4 parts of Smilax glabra.

[0010] Further, the traditional Chinese medicine composition comprises, in terms of weight parts, 3 parts of atractylodes, 2 parts of Szechuan fuzi, 10 parts of sunflower disc, 3 parts of Russian leaf, 3 parts of Luo Shiteng, 6 parts of Daxueteng, 10 parts of Weilingxian, 1 part of Shishengteng, 1 part of Yuanhu, and 6 parts of Lulutong.

[0011] Further, the traditional Chinese medicine composition comprises, in terms of weight parts, 6 parts of atractylodes, 4 parts of Szechuan fuzi, 1 part of sunflower disc, 7 parts of Russian leaf, 5 parts of Luo Shiteng, 4 parts of Daxueteng, 8 parts of Weilingxian, 4 parts of Shishengteng, 4 parts of Yuanhu, and 1 part of Lulutong.

[0012] According to a second aspect of the embodiments of the present application, the present application provides a preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver, as described in any one of the above, and the method comprises:

[0013] According to the prescription ratio, atractylodes, Szechuan fuzi, sunflower disc, Russian leaf, Luo Shiteng, Daxueteng, Weilingxian, Shishengteng, Yuanhu, and Lulutong are weighed, and the medicinal materials are mixed uniformly.

[0014] The effects of each medicinal material used in the present application are as follows:

[0015] Atractylodes is pungent and bitter in taste, warm in nature, and belongs to the spleen, stomach, and liver meridians, and has the effects of drying dampness, invigorating the spleen, dispelling wind and cold, and removing dampness and phlegm; Szechuan fuzi, i.e., Huanglian, is bitter in taste, cold in nature, and belongs to the heart, spleen, stomach, liver, gallbladder, and large intestine meridians, and can clear heat and dry dampness, purge fire and detoxify, and synergize with atractylodes to enhance the ability to remove dampness and clear heat; Sunflower disc contains various alkaloids, flavonoids, and other components, and modern research shows that it has the effect of regulating uric acid metabolism; Russian leaf has the effects of clearing liver and benefiting gallbladder; Luo Shiteng, Daxueteng, Weilingxian, and Shishengteng all have the effects of dispelling wind and dredging collaterals, and can effectively relieve joint pain; Yuanhu, i.e., Rhizoma Corydalis, is pungent and bitter in taste, warm in nature, and belongs to the liver and spleen meridians, and can activate blood and qi, and relieve pain; Lulutong is bitter in taste, neutral in nature, and belongs to the liver and kidney meridians, and can dispel wind and activate collaterals, benefit water, and regulate channels. Each medicinal material is compatible with each other to jointly play the roles of attacking and dissolving accumulation, removing dampness and phlegm, relieving joint pain, reducing uric acid, and clearing liver and benefiting gallbladder, and protecting liver.

[0016] The embodiments of the present application have the following advantages:

[0017] The traditional Chinese medicine composition of the present application has been clinically verified to not only reduce uric acid, but also play the roles of attacking and dissolving accumulation, removing dampness and phlegm, relieving joint pain, and clearing liver and benefiting gallbladder, and protecting liver.

[0018] The traditional Chinese medicine composition of the present application is used in the form of drinking with boiling water, without the need for a complex decocting process, and is convenient and fast, suitable for the pace of modern life, and easy to be accepted by patients.

[0019] The traditional Chinese medicine composition of the present application is made of pure traditional Chinese medicine without adding any chemical synthetic components, has small side effects, high safety, and can be taken for a long time. DETAILED DESCRIPTION

[0020] The present application will be described in greater detail by way of specific embodiments, from which the advantages and the effects of the present application will become apparent to those of ordinary skill in the art. It is obvious that the described embodiments are part of the embodiments of the present application, but not all the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of the present application.

[0021] Embodiment 1

[0022] The present embodiment provides a traditional Chinese medicine composition for reducing uric acid and protecting liver, and the raw materials thereof are: 20 grams of rhizoma et radix valerianae officinalis, 30 grams of radix et rhizoma strophanthi, 80 grams of chrysanthemum disc, 10 grams of Russian leaf, 40 grams of vitex trifolia, 20 grams of sargentodoxa, 50 grams of radix dipsaci, 20 grams of stone south vine, 30 grams of rhizoma hyrcani, and 20 grams of auripila.

[0023] The preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver described above comprises:

[0024] (1) weighing: weighing rhizoma et radix valerianae officinalis, radix et rhizoma strophanthi, chrysanthemum disc, Russian leaf, vitex trifolia, sargentodoxa, radix dipsaci, stone south vine, rhizoma hyrcani, and auripila.

[0025] (2) mixing: placing each herb in a mixing machine and fully stirring and mixing them evenly.

[0026] (3) sub-packaging: packaging the mixed herbs into degradable tea bags according to the specification of 10 grams per bag, and sealing and packaging.

[0027] Embodiment 2

[0028] The present embodiment provides a traditional Chinese medicine composition for reducing uric acid and protecting liver, and the raw materials thereof are: 40 grams of rhizoma et radix valerianae officinalis, 10 grams of radix et rhizoma strophanthi, 50 grams of chrysanthemum disc, 60 grams of Russian leaf, 60 grams of vitex trifolia, 30 grams of sargentodoxa, 10 grams of radix dipsaci, 50 grams of stone south vine, 20 grams of rhizoma hyrcani, and 30 grams of auripila.

[0029] The preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver described above is the same as that of Embodiment 1.

[0030] Embodiment 3

[0031] The present embodiment provides a traditional Chinese medicine composition for reducing uric acid and protecting liver, and the raw materials thereof are: 10 grams of rhizoma et radix valerianae officinalis, 40 grams of radix et rhizoma strophanthi, 20 grams of chrysanthemum disc, 80 grams of Russian leaf, 20 grams of vitex trifolia, 50 grams of sargentodoxa, 30 grams of radix dipsaci, 60 grams of stone south vine, 20 grams of rhizoma hyrcani, and 40 grams of auripila.

[0032] The preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver described above is the same as that of Embodiment 1.

[0033] Example 4

[0034] The present example provides a traditional Chinese medicine composition for reducing uric acid and protecting liver, which raw materials are: 30 grams of rhizoma et radix valerianae officinalis, 20 grams of radix et rhizoma strophanthi, 100 grams of chrysanthemum, 30 grams of Russian leaf, 30 grams of radix trachelii, 60 grams of caulis lonicerae, 100 grams of radix dipsaci, 10 grams of stone vine, 10 grams of radix hyrcani, and 60 grams of auripila.

[0035] The preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver is the same as that in Example 1.

[0036] Example 5

[0037] The present example provides a traditional Chinese medicine composition for reducing uric acid and protecting liver, which raw materials are: 60 grams of rhizoma et radix valerianae officinalis, 40 grams of radix et rhizoma strophanthi, 10 grams of chrysanthemum, 70 grams of Russian leaf, 50 grams of radix trachelii, 40 grams of caulis lonicerae, 80 grams of radix dipsaci, 40 grams of stone vine, 40 grams of radix hyrcani, and 10 grams of auripila.

[0038] The preparation method of the traditional Chinese medicine composition for reducing uric acid and protecting liver is the same as that in Example 1.

[0039] Test Example 1

[0040] 1. 120 cases of hyperuricemia patients (22-60 years old) were selected, including 78 males and 42 females. The selection criteria were as follows: blood uric acid concentration: male blood uric acid > 420 μmol / L, female blood uric acid > 357 μmol / L, and meeting the TCM syndrome differentiation standard of dampness-heat resistance syndrome: main symptoms: obese, dry stool, abdominal distension, joint redness or pain. Secondary symptoms: dry mouth, peculiar smell in the mouth, dark yellow urine. Tongue and pulse: tongue red or dark, yellow and greasy or thick yellow fur, slippery pulse. 2 items of main symptoms (tongue fur is necessary) or 1 item of main symptoms plus 2 items of secondary symptoms (tongue fur is necessary) were required. All patients were randomly divided into treatment groups 1-5, 24 cases in each group, and there was no statistically significant difference in clinical data between groups.

[0041] 2. The traditional Chinese medicine compositions of Examples 1-5 were used in treatment groups 1-5, respectively. The use method was as follows: 1 bag of traditional Chinese medicine tea bag was taken, put into a cup, 300-500 ml of boiled water was added, soaked for 10-15 minutes, and then it could be drunk. 1-2 times a day.

[0042] 3. Efficacy criteria

[0043] Cure: after treatment, main symptoms and signs disappeared, symptom score decreased by ≥95%, and blood uric acid returned to normal.

[0044] Marked effect: after treatment, main symptoms and signs improved significantly, symptom score decreased by ≥70%, and blood uric acid was normal or close to normal.

[0045] Effective: after treatment, the main symptoms and signs are improved, the symptom score is reduced by ≥30%, and the blood uric acid is reduced.

[0046] Invalid: after treatment, the main symptoms and signs are not improved, the symptom score is reduced by <30%, and the blood uric acid is not reduced.

[0047] 4、Results

[0048] After 4 weeks, the results of patients in treatment groups 1-5 are shown in Table 1 below.

[0049] Table 1

[0050] Group Cure Markedly effective Effective Ineffective Effective rate Treatment 1 group 8 8 6 2 91.7％ Treatment 2 group 3 6 10 5 79.2％ Treatment 3 group 5 7 8 4 83.3％ Treatment 4 group 7 4 10 3 87.5％ Treatment 5 group 6 10 5 3 87.5％

[0051] The above shows that the traditional Chinese medicine composition provided by the present application can effectively improve the clinical symptoms of hyperuricemia, and has definite treatment effect.

[0052] And it has been clinically verified to have the effects of attacking hard lumps, removing dampness and phlegm, relieving joint pain, clearing liver and protecting liver, and has good safety, and no obvious adverse reactions are found.

[0053] Although the present application has been described in detail in the foregoing with general description and specific embodiments, some modifications or improvements can be made on the basis of the present application, which is obvious to those skilled in the art. Therefore, these modifications or improvements made on the basis of not deviating from the spirit of the present application, all belong to the scope of the present application claimed.

Claims

1. A Chinese medicine composition for lowering uric acid and protecting the liver, characterized in that: The traditional Chinese medicine composition comprises, by weight, 1-6 parts of atractylodes, 1-4 parts of coptis chinensis, 1-10 parts of sunflower disc, 1-10 parts of euphorbia cerifera, 1-6 parts of trachelospermum schrenckii, 1-6 parts of safflower vine, 1-10 parts of clematis root, 1-6 parts of safflower vine, 1-4 parts of corydalis yanhusuo, and 1-6 parts of rhizoma liquidambar formosana.

2. The Chinese medicine composition for lowering uric acid and protecting the liver according to claim 1, characterized in that The Chinese medicine composition comprises, by weight, 2 parts of Atractylodes lancea, 3 parts of Coptis chinensis, 8 parts of Helianthus annuus, 1 part of Oise leaves, 4 parts of Trachelospermum schizandrae, 2 parts of Sargentodoxae, 5 parts of Clematidis, 2 parts of Heather strychnos, 3 parts of Corydalis yanhusuo and 2 parts of Smilax glabra.

3. The Chinese medicine composition for lowering uric acid and protecting the liver according to claim 1, characterized in that The Chinese medicine composition comprises, by weight, 4 parts of Atractylodes lancea, 1 part of Coptis chinensis, 5 parts of Helianthus annuus, 6 parts of Oise leaves, 6 parts of Trachelospermi schizandrae, 3 parts of Sargentodoxae, 1 part of Clematidis, 5 parts of Heather strychnine, 2 parts of Corydalis yanhusuo and 3 parts of Smilax glabra.

4. The Chinese medicine composition for lowering uric acid and protecting the liver according to claim 1, characterized in that The Chinese medicine composition comprises, by weight, 1 part of Atractylodes lancea, 4 parts of Coptis chinensis, 2 parts of Helianthus annuus, 8 parts of Oise leaves, 2 parts of Trachelospermum schrenkiana, 5 parts of Sargentodoxae cyperi, 3 parts of Clematidis, 6 parts of Heather strychnos nux vomica, 2 parts of Corydalis yanhusuo and 4 parts of Smilax glabra.

5. The Chinese medicine composition for lowering uric acid and protecting the liver according to claim 1, characterized in that: The Chinese medicine composition comprises, by weight, 3 parts of Atractylodes lancea, 2 parts of Coptis chinensis, 10 parts of Helianthus annuus, 3 parts of Oise leaves, 3 parts of Trachelospermum schrenkiana, 6 parts of Sargentodoxae, 10 parts of Clematidis, 1 part of Heather strychnos, 1 part of Corydalis yanhusuo, and 6 parts of Smilax glabra.

6. The Chinese medicine composition for lowering uric acid and protecting the liver according to claim 1, characterized in that: The Chinese medicine composition comprises, by weight, 6 parts of Atractylodes lancea, 4 parts of Coptis chinensis, 1 part of Helianthus annuus, 7 parts of Oise leaves, 5 parts of Trachelospermum schizandrae, 4 parts of Sargentodoxae, 8 parts of Clematidis, 4 parts of Heather strychnos, 4 parts of Corydalis yanhusuo, and 1 part of Smilax glabra.

7. The method for preparing the Chinese medicinal composition for lowering uric acid and protecting the liver according to any one of claims 1 to 6, characterized in that: The method comprises: According to the formula ratio, weigh out Atractylodes lancea, Coptis chinensis, Helichrysanthemum officinale, Oise leaves, Trachelospermum officinale, Sargentodoxae, Clematis chinensis, Heather strychnos nux vomica, Corydalis yanhusuo and Fructus lucidum, and mix them evenly.