Cell image analysis system and slide storage method thereof

Abstract

The invention provides a cell image analysis system and a slide storage method thereof, and the system comprises: a first slide box for loading a to-be-detected slide; a control device; the slide loading device is controlled by the control device to load the slide to be detected in the first slide box to the detection platform; the detection platform is used for bearing a to-be-detected slide for detection; the control device controls the imaging device to shoot cells of a sample in the to-be-detected slide on the detection platform, and the shot to-be-detected slide is a detected slide; the slide unloading device is controlled by the control device to unload the detected slide from the detection platform into the second slide box; and the second slide box is used for loading the tested slide, and the capacity of the second slide box is greater than that of the first slide box. According to the system and the method, the frequency of frequently replacing the slide box by a user is greatly reduced, the slide blockage caused by full loading of the slide box is avoided, and the storage efficiency of the slides is greatly improved.

Description

[0001] This application is a divisional application of the Chinese invention patent application with application number "202110540914.7". The filing date of the original application is May 18, 2021, and the title of the invention is "Cell Image Analysis System and Slide Storage Method Thereof". Technical Field

[0002] The present invention relates to the field of medical technology, and more particularly to slide storage. Background Art

[0003] When analyzing cell morphology, the cell image analyzer needs to place several slides in a temporary storage container (e.g., a slide basket) to facilitate the transfer and delivery of the slides, improving the efficiency and convenience of the transfer. The slide basket carries several slides and transports the slide basket to the sampling channel of the cell image analyzer. The cell image analyzer then clamps the slides one by one into the cell image analyzer for cell morphology analysis. The completed slides are returned to the slide basket or placed in another slide basket. These completed slides are then placed and stored together for easy reference later.

[0004] However, current slide baskets have a limited capacity, and completed slides quickly fill the entire basket. This necessitates frequent removal of full baskets, which can cause the cell image analyzer to become blocked and shut down. Furthermore, the low storage density of the slides in the basket makes it unsuitable for long-term storage. Consequently, users must manually remove each slide and place them in a separate container that can hold multiple slides tightly. This frequent, time-consuming and labor-intensive operation is a daily necessity for operators. Delayed removal can also cause the slides to become blocked, halting the cell image analyzer.

[0005] Furthermore, existing slide recovery baskets are open only on one side, so slides must be placed in and removed from the basket from the same side. This makes cleaning the slides difficult, hinders usability, and creates a poor user experience. Furthermore, after analyzing blood smears, lens oil remains on the surface. Existing slide recovery baskets lack oil-blocking, oil-guiding, and oil-collecting functions, resulting in significant oil residue after long-term use, hindering reuse. Summary of the Invention

[0006] The embodiments of the present invention provide a cell image analysis system for repositioning a smear and a slide storage method thereof, so as to solve at least one of the above-mentioned problems.

[0007] According to a first aspect of the present invention, there is provided a cell image analysis system, the system comprising:

[0008] The first slide box is used to load the slides to be tested;

[0009] control devices;

[0010] a slide loading device, the control device controls the slide loading device to load the to-be-tested slides in the first slide cassette to a detection platform;

[0011] the detection platform, configured to carry the to-be-tested slides for detection;

[0012] an imaging device, the control device controls the imaging device to take pictures of cells of samples in the to-be-tested slides on the detection platform, and the to-be-tested slides after the taking of pictures are measured slides;

[0013] a slide unloading device, the control device controls the slide unloading device to unload the measured slides from the detection platform to a second slide cassette;

[0014] the second slide cassette, configured to load the measured slides, and a capacity of the second slide cassette is greater than a capacity of the first slide cassette.

[0015] According to a second aspect of the present application, a cell image analysis system is provided, the system comprising:

[0016] a control device;

[0017] a slide loading device, configured to load to-be-tested slides to a detection platform;

[0018] the detection platform, configured to carry the to-be-tested slides for detection;

[0019] an imaging device, configured to take pictures of cells of samples in the to-be-tested slides on the detection platform, and the to-be-tested slides after the taking of pictures are measured slides;

[0020] a slide unloading device, configured to unload the measured slides from the detection platform to a recovery slide cassette;

[0021] the recovery slide cassette, configured to load the measured slides, and the recovery slide cassette is configured to accommodate at least 20, 40, 60, 80, or 100 slides.

[0022] According to a third aspect of the present application, a slide storage method of a cell image analysis system is provided, the method comprising:

[0023] sequentially obtaining to-be-tested slides from a first slide cassette and loading the to-be-tested slides to a detection platform;

[0024] detecting samples in the to-be-tested slides on the detection platform, and the to-be-tested slides after the detection are measured slides;

[0025] According to the sample attribute of the measured slide, the measured slide is unloaded from the detection platform to a corresponding region in a plurality of preset regions of a second slide box, wherein the plurality of preset regions are set by a user according to the sample attribute.

[0026] The second slide box loads measured slides from a plurality of the first slide boxes.

[0027] According to the cell image analysis system and the slide storage method thereof, the measured slides are directly placed into the large-capacity slide box and stored for a long time, which not only greatly reduces the frequency of replacing the slide box by the user, avoids the blocking of the slides due to the full slide box, but also directly uses the large-capacity slide box for long-term storage, without manually transferring the measured slides to the long-term storage container, thereby greatly improving the storage efficiency of the slides. BRIEF DESCRIPTION OF DRAWINGS

[0028] The above and other objects, features and advantages of the present application will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings in which like reference characters refer to like parts throughout the figures. The drawings provided are for illustrative purposes only and, therefore, should not be considered to be limiting of the present application. In the drawings:

[0029] Figure 1a An example of a slide basket is shown;

[0030] Figure 1b An example of a slide storage container is shown;

[0031] Figure 2 is a structural schematic diagram of a cell image analysis system according to an embodiment of the present application;

[0032] Figure 3a and Figure 3b is an example of a slide placement direction according to an embodiment of the present application;

[0033] Figure 4 is a structural schematic diagram of a control device according to an embodiment of the present application;

[0034] Figures 5a-5c is an example of a slide loading device according to an embodiment of the present application;

[0035] Figures 6a-6c is an example of a slide loading device according to an embodiment of the present application;

[0036] Figure 7 is a further structural schematic diagram of a cell image analysis system according to an embodiment of the present application;

[0037] Figures 8a-8cis an example of a slide unloading device according to an embodiment of the present invention;

[0038] Figures 9a-9c is an example of a slide unloading device according to an embodiment of the present invention;

[0039] Figures 10a-10d It is the storage method of the slides;

[0040] Figure 11a and Figure 11b is an example of a second slide box arranged in a single row according to an embodiment of the present invention;

[0041] Figure 12a and Figure 12b is an example of a second slide box arranged in a double row according to an embodiment of the present invention;

[0042] Figure 13 is an example of a second slide box arranged in three rows according to an embodiment of the present invention;

[0043] Figure 14a and Figure 14b is an example of a preset area of ​​a second slide box according to an embodiment of the present invention;

[0044] Figures 15a-15c is an example of slides arranged at intervals according to an embodiment of the present invention;

[0045] Figure 16 is an example of displaying a second slide box in a display component according to an embodiment of the present invention;

[0046] Figure 17 is a schematic perspective view of a second slide box according to an embodiment of the present invention as viewed from the left side;

[0047] Figure 18 yes Figure 17 A schematic perspective view of a second slide box viewed from the right side;

[0048] Figure 19 yes Figure 17 Another schematic perspective view of the second slide box viewed from the left side;

[0049] Figure 20 is a schematic perspective view of a receiving seat according to an embodiment of the present invention;

[0050] Figure 21 is a schematic perspective view of a side panel of a second slide box according to an embodiment of the present invention;

[0051] Figure 22 is a partial perspective view of a second slide box according to an embodiment of the present invention;

[0052] Figure 23Structure diagram of the recycling slide box (single slot group) for storing the detected sample slides in another embodiment of the present application;

[0053] Figure 24 and 25 Structure diagram of the recycling slide box (double slot group) for storing the detected slides in another embodiment of the present application from different angles;

[0054] Figure 26 Diagram of the sample slide inclined in the slot in an embodiment of the present application;

[0055] Figure 27 Diagram of the location of the readable unit and the guide information in an embodiment of the present application;

[0056] Figure 28 is a schematic flow chart of the slide storage method of the cell image analysis system according to an embodiment of the present application. DETAILED DESCRIPTION

[0057] In order to make the objects, technical solutions and advantages of the present application more obvious, the following will describe the example embodiments according to the present application in detail with reference to the drawings. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments of the present application, and it should be understood that the present application is not limited to the example embodiments described herein. Based on the embodiments of the present application described in the present application, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of the present application.

[0058] In the current cell image analysis process, the slide basket for storing the slides generally has a small volume and can only accommodate a few slides, such as Figure 1a as shown, Figure 1a shows an example of a slide basket. Moreover, in order to realize the operation of the machine to pick up and place the slides, the slides are relatively far apart, so the density of the slides that the slide basket can accommodate is very low. If the existing slide basket is used to store the slides that have been analyzed, the user needs to frequently take away the full slide basket, otherwise the machine will be blocked and stopped, which greatly reduces the efficiency of cell image analysis.

[0059] Based on the above considerations, the present application provides a cell image analysis system according to an embodiment of the present application. Referring to Figure 2 , Figure 2 shows a structure diagram of the cell image analysis system according to an embodiment of the present application. As shown in Figure 2 , the system 200 comprises:

[0060] a first slide box 210 for loading the sample slides to be detected;

[0061] a control device 220;

[0062] a slide loading device 230, the control device 220 controls the slide loading device 230 to load the to-be-tested slides in the first slide box 210 to a detection platform 240;

[0063] the detection platform 240, for carrying the to-be-tested slides for detection;

[0064] an imaging device 250, the control device 220 controls the imaging device 250 to take photos of cells of samples in the to-be-tested slides on the detection platform, and the to-be-tested slides after photo shooting are measured slides;

[0065] a slide unloading device 260, the control device 220 controls the slide unloading device 260 to unload the measured slides from the detection platform to a second slide box 270;

[0066] the second slide box 270, for loading the measured slides, the capacity of the second slide box 270 is greater than that of the first slide box 210.

[0067] In the embodiment of the present application, the cell image analysis system directly puts the measured slides after detection into the second slide box with a greater capacity than the first slide box for storing to-be-tested slides, and the second slide box with a large capacity can accommodate slides from multiple first slide boxes, so the user does not need to frequently replace the full second slide box, and compared with the traditional small-capacity slide basket, the frequency of replacing the slide box is greatly reduced, the situation of machine running blockage caused by insufficient capacity of the slide box is greatly improved, and the inconvenience caused by frequent replacement of the slide box is also improved.

[0068] In addition, the traditional slide basket is not suitable for long-term storage of slides because of low slide storage density. In actual application, medical institutions such as hospitals require archiving of measured slides for 2 weeks to 2 years. If the traditional slide basket is used to store the measured slides, a large storage space is required. Therefore, the user usually needs to manually take out the slides one by one and place them in other slide storage containers that can tightly store multiple slides. Figure 1b As shown in FIG. 5, Figure 1b an example of a slide storage container is shown. This process greatly occupies the time and energy of the user, and if there is a slight delay, it will also cause slide blockage and stop machine, which is more unfavorable for storage of the measured slides.

[0069] However, in the cell image analysis system provided by the embodiments of the present application, the second slide box can also directly serve as a storage container. In this way, the user can directly use the second slide box containing the measured slides for long-term storage, without manually moving the measured slides into a long-term storage container, greatly reducing the workload and error rate of the user, and avoiding damage or loss of the slides due to manual operation errors. Directly using the second slide box for long-term storage can also improve the efficiency of slide storage.

[0070] Therefore, the second slide box can be placed in the cell image analysis system as a temporary storage module for slides, and can also be taken out of the cell image analysis system as a long-term storage container for slides.

[0071] Optionally, the slides in the first slide box 210 and / or the second slide box 270 can be placed vertically or horizontally. Referring to Figure 3a and Figure 3b , Figure 3a and Figure 3b Fig. 4 shows an example of the slide placement direction according to an embodiment of the present application. Figure 3a In Fig. 4, the slides are placed vertically; Figure 3b In Fig. 5, the slides are placed horizontally.

[0072] In some embodiments, the first slide box 210 is configured to accommodate at least 10 slides.

[0073] It should be understood that the slide placement direction in the first slide box and the second slide box can be the same or different, which is not limited herein.

[0074] Optionally, referring to Figure 4 , Figure 4 Fig. 6 shows a structural schematic diagram of a control device according to an embodiment of the present application. As shown in Figure 4 The control device 220 at least includes a processing component 431, a RAM 432, a ROM 433, a communication interface 434, a storage 436, and an I / O interface 435, wherein the processing component 431, the RAM 432, the ROM 433, the communication interface 434, the storage 436, and the I / O interface 435 can communicate through a bus 437.

[0075] The processing component 431 can be implemented by software, hardware, firmware or any combination thereof, and can use at least one of circuit, single or multiple Application Specific Integrated Circuit (ASIC), Digital Signal Processor (DSP), Digital Signal Processing Device (DSPD), Programmable Logic Device (PLD), Field Programmable Gate Array (FPGA), Central Processing Unit (CPU), controller, microcontroller, microprocessor, etc., so that the processing component 431 can execute part or all of the steps of the cell image analysis method and the slide storage method in various embodiments of the present application or any combination of steps therein.

[0076] The memory 436 stores various computer programs and data required for the processor component 431 to execute the computer programs, such as an operating system and application programs. In addition, if necessary, data required to be stored locally during the sample detection process can also be stored in the memory 436.

[0077] In some embodiments, the memory 436 can be a volatile memory or a nonvolatile memory, and also can include both volatile and nonvolatile memory. The nonvolatile memory can be a Read Only Memory (ROM), a Programmable Read-Only Memory (PROM), an Erasable Programmable Read-Only Memory (EPROM), an Electrically Erasable Programmable Read-Only Memory (EEPROM), a ferromagnetic random access memory (FRAM), a flash memory, a magnetic surface memory, an optical disc, or a Compact Disc Read-Only Memory (CD-ROM). The magnetic surface memory can be a disk memory or a tape memory. The volatile memory can be a Random Access Memory (RAM) used as an external cache. By way of example, but not limitation, many forms of RAM can be used, such as Static Random Access Memory (SRAM), Synchronous Static Random Access Memory (SSRAM), Dynamic Random Access Memory (DRAM), Synchronous Dynamic Random Access Memory (SDRAM), Double Data Rate Synchronous Dynamic Random Access Memory (DDR SDRAM), Enhanced Synchronous Dynamic Random Access Memory (ESDRAM), Sync Link Dynamic Random Access Memory (SLDRAM), and Direct Rambus Random Access Memory (DRRAM).The memory 436 described in the embodiments of the present application is intended to include these and any other suitable type of memory.

[0078] The I / O interface 435 is composed of a serial interface such as USB, IEEE 1394 or RS-232C, a parallel interface such as SCSI, IDE or IEEE 1284, and an analog signal interface composed of a D / A converter and an A / D converter. The input device composed of a keyboard, a mouse, a trackball, a click wheel, a key, a button, a touchpad, a touch screen or other control components is connected to the I / O interface 435, and a user can directly input data to the control device 130 by using the input device. In addition, the display with display function, such as a liquid crystal screen, a touch screen, an LED display screen and the like, can also be connected to the I / O interface 435, and the control device 220 can output the processed data to the display in the form of image display data for display, such as cell images, analysis data, instrument running parameters and the like.

[0079] The communication interface 434 can be an interface of any communication protocol. The communication interface 434 communicates with the outside through a network. The control device 220 can transmit data between any device connected through the network by using a certain communication protocol through the communication interface 434. It should be understood that the sample analysis system according to the embodiments of the present application is not limited by the communication interface, whether it is an interface of a communication protocol known at present or an interface of a communication protocol developed in the future, which can be used in the cell image analysis system according to the embodiments of the present application to realize the function of communicating with the outside through the network, which is not limited herein.

[0080] The cell image analysis system according to the embodiments of the present application can provide a corresponding operation interface for an operator to operate when in operation. In the above operation interface, various corresponding controls such as an identification check box or a menu bar can be included, so that the operator can input operation instructions on the operation interface according to actual use to realize the analysis of cells on the sample slide by the cell image analysis system.

[0081] Optionally, the first slide box 210 and the second slide box 270 are arranged on two sides of the imaging device 250 or the detection platform 240, respectively.

[0082] In some embodiments, when the first slide box 210 and the second slide box 270 are arranged on two sides of the imaging device 250, the slide loading device 230 clamps the to-be-tested slide from the first slide box 210, moves and loads it onto the detection platform 240, and after being photographed by the imaging device 250, the slide is clamped, moved and unloaded by the slide unloading device 260 as a tested slide to the second slide box.

[0083] In some embodiments, when the first slide box 210 and the second slide box 270 are arranged on both sides of the detection platform 240, the slide loading device 230 clamps the slide to be tested from the first slide box 210 and loads it onto the detection platform 240. After being photographed by the imaging device 250, it is regarded as a tested slide and is clamped and unloaded by the slide unloading device 260 into the second slide box.

[0084] Optionally, the slide loader 230 can be connected to a transfer track to transport slides to be tested from other devices (such as slides to be tested prepared by a slide preparation device) to the cell image analysis system 200; the slide loader 230 may also not be connected to an external track, in which case the user can directly place the slides to be tested in the first slide box 210.

[0085] Optionally, the slide loading device 230 may include: a mechanical conveying part and a slide input module, wherein the mechanical conveying part automatically places the slide to be tested on the slide input module; and the slide input module loads the slide to be tested onto the detection platform.

[0086] Among them, the mechanical conveyor automatically loads the slides to be tested, which can increase the processing speed of the system and reduce the workload of users (such as medical staff), while the slide input module can cache the slides to be tested.

[0087] In some embodiments, see Figure 5a , Figure 5a An example of a slide loading device according to an embodiment of the present invention is shown. Figure 5a In the embodiment, the slide loading device 530 includes: a mechanical conveying part 531 and a slide input module 532; wherein, the mechanical conveying part 531 can be implemented as a robotic arm, for example, which clamps the slide to be tested 533 upward from the vertically placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the slide input module 532.

[0088] In other embodiments, see Figure 5b , Figure 5b Still another example of the slide loading device according to the embodiment of the present invention is shown. Figure 5b In the embodiment, the slide loading device 530 includes: a mechanical conveying part 531 and a slide input module 532; wherein, the mechanical conveying part 531 can be implemented as a robotic arm, for example, which clamps the slide to be tested 533 out of the horizontally placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the slide input module 532.

[0089] It should be understood that in the above embodiment, when the distance between the first slide box and the slide input module is relatively close (for example, less than or equal to a preset value), and the robotic arm does not need to move horizontally and / or vertically to hold the slide, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the vertically or horizontally placed slide to be tested onto the slide input module after gripping it.

[0090] In some embodiments, see Figure 5c , Figure 5c Still another example of the slide loading device according to the embodiment of the present invention is shown. Figure 5c In the embodiment, the mechanical conveying part can also be implemented as a pushing device (not shown), which pushes or pulls the slide to be tested 533 directly horizontally from the slide to be tested horizontally placed in the first slide box to the slide input module 532.

[0091] In some embodiments, the slide input module 532 transfers the slide to be tested placed thereon to the detection platform. Further, the slide input module 532 can be used to transfer the slide to be tested to a position on the detection platform facing the imaging device via a transmission belt.

[0092] Alternatively, the slide loading device 230 may also include only a mechanical transport unit, thereby further improving detection efficiency and reducing the size of the cell image analysis system.

[0093] In some embodiments, see Figure 6a , Figure 6a An example of a slide loading device according to an embodiment of the present invention is shown. Figure 6a In the embodiment, the slide loading device 630 includes a mechanical conveying part 631, which can be implemented as a robotic arm. The robotic arm clamps the slide to be tested 632 upward from the vertically placed slide to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the detection platform.

[0094] In other embodiments, see Figure 6b , Figure 6b Another example of a slide loading device according to an embodiment of the present invention is shown. The robotic arm 631 clamps the slide to be tested 632 out of the horizontally placed slides to be tested in the first slide box, moves it horizontally and / or vertically, and then flips it to clamp the slide to be tested to the detection platform.

[0095] It should be understood that in the above embodiment, when the distance between the first slide box and the slide input module is relatively close (for example, less than or equal to a preset value), and the robotic arm does not need to move horizontally and / or vertically to hold the slide, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the vertically or horizontally placed slide to be tested onto the slide input module after gripping it.

[0096] In some embodiments, referring to Figure 6c , Figure 6c Another example of a slide loading device according to an embodiment of the present application is shown. Figure 6c In some embodiments, the mechanical conveying part can be implemented as a pushing device (not shown) for example, which directly pushes or pulls the slide 632 to be tested horizontally out of the horizontally placed slide to be tested in the first slide box to the detection platform.

[0097] Optionally, the detection platform 240 can include:

[0098] a slide moving device 241 for moving and fixing the slide relative to the imaging device 250 so that the imaging device 250 can take cell images of a specific area of the slide.

[0099] In some embodiments, the slide moving device can be provided with a fixing part (e.g. a clamp) for clamping the smear to keep the position stable.

[0100] In some embodiments, the detection platform 240 can be located below the imaging device 250. After the slide device loads the slide to be tested onto the detection platform, the imaging device located above the detection platform can take pictures of the slide to obtain cell images of the sample in the slide.

[0101] In some embodiments, the shape of the detection platform includes but is not limited to square, circular, etc. The position where the detection platform places the slide is provided with a light hole to ensure the brightness of the taken images.

[0102] Optionally, as shown in Figure 2 the imaging device 250 includes a lens group 251 and a camera 252, and is used for taking pictures of the cells in the sample smeared on the slide to obtain cell images.

[0103] Referring to Figure 7 , Figure 7 Another structural schematic diagram of a cell image analysis system according to an embodiment of the present application is shown. As shown in Figure 7 the imaging device 700 includes a camera 710 and a lens group 720, wherein the lens group 720 can include a first objective lens 720a, a second objective lens 720b and an adapter 720c, and optionally, the lens group 720 can further include an ocular lens (not shown). The first objective lens 720a can be a 10x objective lens for example, and the second objective lens 720b can be a 100x objective lens for example. The lens group 720 can further include a third objective lens 720d, which can be a 40x objective lens for example. A user can select any magnification of the objective lens to take pictures of the slide to be tested 731, as shown in Figure 7As shown, a slide loading device (not shown) loads the slide to be tested in the first slide box 730 onto the detection platform, a slide moving device 740 on the detection platform moves the slide to be tested 731 into the field of view of the objective lens and fixes the slide to be tested, and an imaging device captures an image of the sample cells in the slide to be tested to obtain a cell image.

[0104] Optionally, the slide loading device 230 and the slide unloading device 260 may be different devices independent of each other.

[0105] Optionally, the slide unloading device 260 includes a mechanical conveyor unit and a slide output module. The mechanical conveyor unit automatically places the tested slides into the slide output module, and the slide output module unloads the tested slides into a second slide box. The slide output module can cache the tested slides.

[0106] In some embodiments, see Figure 8a , Figure 8a An example of a slide unloading apparatus according to an embodiment of the present invention is shown. Figure 8a In the embodiment, the slide unloading device 860 includes: a mechanical conveying part 861 and a slide output module 862; wherein, the mechanical conveying part 861 can be implemented as a robotic arm, for example, and the detection platform unloads the tested slide to the slide output module 862. The robotic arm clamps the tested slide 863 on the slide output module 862, moves it horizontally and / or vertically, and then flips it to place the tested slide vertically in the second slide box.

[0107] In other embodiments, see Figure 8b , Figure 8b Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 8b In the embodiment, the slide unloading device 860 includes: a mechanical conveying part 861 and a slide input module 862; wherein, the mechanical conveying part 861 can be implemented as a robotic arm, for example, and the detection platform unloads the tested slide to the slide output module 862. The robotic arm clamps the tested slide 863 on the slide output module 862, moves it horizontally and / or vertically, and then flips it to place the tested slide horizontally in the second slide box.

[0108] It should be understood that in the above embodiment, when the distance between the second slide box and the slide output module is relatively close (for example, less than or equal to a predetermined value), and the robotic arm does not need to grip the slide and move horizontally, the robotic arm may also omit the horizontal and / or vertical movement and directly flip the gripped measured slide and place it vertically or horizontally in the second slide box.

[0109] In some embodiments, the inspection platform transfers the tested slide placed thereon to the slide output module 862. Furthermore, the inspection platform may be used to transfer the tested slide to the position of the slide output module 862 via a conveyor belt.

[0110] In some embodiments, see Figure 8c , Figure 8c Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 8c In the embodiment, the mechanical conveying portion may also be implemented as a pushing device (not shown), which pushes the measured slides 863 on the slide input module 862 directly and horizontally into the second slide box.

[0111] Alternatively, the slide unloading device 260 may also include only a mechanical conveying unit, thereby further improving the slide unloading efficiency and reducing the size of the cell image analysis system.

[0112] In some embodiments, see Figure 9a , Figure 9a An example of a slide unloading apparatus according to an embodiment of the present invention is shown. Figure 9a In the embodiment, the slide unloading device 960 includes a mechanical conveying part 961, which can be implemented as a robotic arm. The robotic arm clamps the tested slide 963 on the detection platform, moves it horizontally and / or vertically, and then flips it to place the tested slide vertically in the second slide box.

[0113] In other embodiments, see Figure 9b , Figure 9b Another example of a slide unloading device according to an embodiment of the present invention is shown. The robotic arm 961 clamps the tested slide 962 on the detection platform, moves it horizontally and / or vertically, and then flips it to place the tested slide 963 horizontally in the second slide box.

[0114] It should be understood that in the above embodiment, when the distance between the second slide box and the slide output module is relatively close (for example, less than or equal to a predetermined value), and the robotic arm is not required to grip the slide and move horizontally and / or vertically, the robotic arm may also omit the horizontal and / or vertical movement and place the measured slide vertically or horizontally in the second slide box.

[0115] In some embodiments, see Figure 9c , Figure 9c Still another example of the slide unloading device according to the embodiment of the present invention is shown. Figure 9c In the embodiment, the mechanical conveying portion 961 can also be implemented as a pushing device, which pushes the slide to be tested 963 horizontally from the tested slide on the detection platform directly into the second slide box.

[0116] Figures 10a-10dThe storage mode of the slide is shown. Figure 10a The storage slide mode of vertical forward placement is shown, Figure 10b The storage slide mode of horizontal forward placement is shown, Figure 10c The storage slide mode of vertical lateral placement is shown, Figure 10d The storage slide mode of horizontal forward-lateral placement is shown; however, the slide label cannot be directly and clearly seen in the above-mentioned modes. Therefore, it is very difficult to find the required slide from the slide storage container for long-term storage of the slide. Moreover, in order to reduce the storage space occupied by the slide, the interval between the slides is very small, so that it is not easy to take out the slide by fingers, and it can be very difficult to take out the slide, or several slides are taken out at a time, and the target slide is selected from the several slides, thus, the user is brought great inconvenience. According to the embodiment of the present application, the second slide box is used as a long-term storage container, which can facilitate the user to find the sample and facilitate the user to save and manage the sample.

[0117] Optionally, the second slide box 270 comprises: the second slide box comprises a plurality of adjacent accommodation spaces with a settable number, and the plurality of adjacent accommodation spaces are arranged in a single row or multiple rows.

[0118] Referring to Figures 11a-11b , Figure 11a and Figure 11b An example of the second slide box arranged in a single row according to the embodiment of the present application is shown. Referring to Figure 12a and Figure 12b , Figure 12a and Figure 12b An example of the second slide box arranged in two rows according to the embodiment of the present application is shown. Referring to Figure 13 , Figure 13 An example of the second slide box arranged in three rows according to the embodiment of the present application is shown.

[0119] In the second slide box, the interval between the slides is small, and only the sample (blood film) on the slide needs to be ensured not to be damaged, so that as many slides as possible can be accommodated in a unit space. The capacity of the second slide box can be configured by the user according to the needs, so as to meet the needs of various occasions in actual application. For example, different hospitals or users have different needs, and the user can configure the capacity of the second slide box according to different needs to meet the needs of half a day, a day, or even a week or other preset time period.

[0120] In some embodiments, the capacity of the second slide box is at least 5 times the capacity of the first slide box. For example, when the first slide box is configured to hold 10 slides to be tested, the second slide box is configured to hold at least 50 slides that have been tested. Further, the second slide box can include 50 adjacent holding spaces arranged in a single row, or 50 adjacent holding spaces arranged in two rows, each row including 25 holding spaces.

[0121] In some embodiments, the second slide box is configured to hold at least 40, 60, 80, or 100 slides. For example, a second slide box arranged in a single row can be configured to hold 60 slides, or a second slide box arranged in two rows can be configured to hold 60 slides (30 slides in each row).

[0122] Optionally, the second slide box is provided with a hand-holding device for holding. The hand-holding device can be implemented as a handle provided on the outer wall of one side of the second slide box, so that the second slide box is easy to hold and transfer, and is convenient for users to take and place, and is convenient for storing slides.

[0123] Optionally, the second slide box is provided with an oil storage device for collecting mirror oil of the slides that have been tested in the second slide box. The oil storage device can be provided at the bottom of the second slide box to prevent the mirror oil remaining on the slides from hindering the taking and placing of the slides.

[0124] Optionally, the first slide box and the second slide box are respectively arranged on two sides of the imaging device or the detection platform.

[0125] Optionally, the second slide box is provided with an elastic device for fixing the slides that have been tested placed in the second slide box. The elastic device can clamp the slides in the holding spaces, so that even if the second slide box is tilted or inverted, the slides will not be separated from the holding spaces.

[0126] Optionally, the second slide box 270 includes:

[0127] A plurality of settable preset areas, and the control device controls the slide unloading device to move the slides that have been tested to the corresponding preset areas of the second slide box according to preset rules.

[0128] The user can set the capacity, position, and number (number of preset areas) of the preset areas according to needs.

[0129] In some embodiments, the preset areas can be set according to sample attributes, including sample information, pathological information (such as disease type), patient characteristics, detection time, or sample collection source (such as the department where the sample is collected).

[0130] In some embodiments, the preset rule comprises: moving the measured slide to a preset area corresponding to the sample attribute of the measured slide.

[0131] Referring to Figure 14a and Figure 14b , Figure 14a and Figure 14b An example of preset areas of a second slide box according to an embodiment of the present application is shown. In some embodiments, a user can set the preset areas in the second slide box according to the sample collection source in the slide, such as a department, and the like, such as Figure 14a shown, Figure 14a includes four preset areas: area A, area B, area C, and area D, corresponding to department A, department B, department C, and other departments, respectively. Then, after the slides in the first slide box are detected in turn, the slides from department A can be placed in area A for storage, the slides from department B can be placed in area B for storage, the slides from department C can be placed in area C for storage, and the slides from other departments can be placed in area D for storage. In this way, when a user searches for a slide in the future, the user can search only for the slide in area B according to the search information, such as the collection source being department B, greatly improving the search efficiency of the slide. Similarly, in some embodiments, as shown in Figure 14b shown, Figure 14b includes three preset areas: area A, area B, and area C, and the capacity of area A is the sum of the capacities of area B and area C. It should be understood that a user can also set different preset areas according to other sample attributes, which are not limited herein.

[0132] It should be noted that the above embodiments are only for illustration and are not intended to limit the second slide box to be arranged in two rows. Whether the second slide box is arranged in one row or multiple rows, it can be divided into a plurality of preset areas as needed.

[0133] In some embodiments, the preset rule further comprises: determining the direction of the measured slide when placed in the second slide box according to the direction of the second slide box, and / or placing the measured slides in the second slide box at a preset interval.

[0134] When the measured slides are inserted into the second slide box, the label areas of the measured slides can be blocked by each other, which is not convenient for searching and taking the slides. Therefore, a user can insert the measured slides at a preset interval according to the use needs, so as to pull apart the measured slides and facilitate viewing of the label information of the measured slides. In addition, the measured slides are placed at an interval, so that a user can easily take out a measured slide without affecting other measured slides. Referring again to Figures 10a-10dWhen the control device controls the slide unloading device to unload the measured slides into the second slide box according to the slide placement direction shown in the second slide box, the direction of the second slide box can be determined first, and then the slide unloading device can unload the measured slides into the second slide box according to the slide placement direction of the second slide box.

[0135] Referring to Figures 15a-15c , Figures 15a-15c An example of the slides arranged at intervals is shown. Figure 15a In some embodiments, the measured slides in the second slide box are arranged without intervals. Figure 15b In some embodiments, the measured slides in the second slide box are arranged with one slide interval. Figure 15c In some embodiments, the measured slides in the second slide box are arranged with two slide intervals. It should be understood that the interval between the slides in the second slide box can be set by the user as needed, and is not limited herein.

[0136] That is, the user can set at least one of the capacity, arrangement, preset area setting, and slide placement manner (including direction and / or interval between slides) of the second slide box, which provides great flexibility for slide storage, meets the needs of the user in various occasions, and improves storage efficiency.

[0137] Optionally, the second slide box comprises an identification part, and the identification part comprises a manual label and / or an electronic label, and the manual label and / or the electronic label are used to record characteristic information of the second slide box.

[0138] When the second slide box is directly used as a container for long-term storage of slides, in order to facilitate the user to quickly find samples later, not only the information of the slide box itself can be identified on the second slide box, but also each measured slide stored in the slide box can be identified.

[0139] In some embodiments, each accommodation space on the second slide box can be provided with a corresponding identifier (such as the number of each row and / or each column) to indicate the position of the accommodation space, which is helpful for quickly locating the stored slides.

[0140] In some embodiments, the second slide box comprises a manual label. The user can manually write information of the second slide box, such as number (ID information), name, detection department, detection time, or detection personnel, and the like, at the manual label.

[0141] In some embodiments, the second slide box comprises an electronic tag. In this way, the user can not only store information such as the number (ID information), name, detection department, detection time, or detection personnel, etc. of the second slide box in the electronic tag, but also record the relevant information of the measured slide by editing the electronic tag (such as an electronic chip, RFID), so as to facilitate the subsequent quick search and positioning of the sample.

[0142] In some embodiments, the electronic tag is also used to record the index information, storage location information, characteristic information of the sample, and / or detection result of the sample of each measured slide in the second slide box.

[0143] Specifically, when the user needs to search for a certain measured slide, the user can query the corresponding storage system according to the known index information of the measured slide, such as the ID information of the slide itself, so as to obtain the number of the second slide box in which the measured slide is located and the position of the measured slide in the slide box, and quickly locate the measured slide that needs to be searched, thereby greatly facilitating the management and search of the user for the slide.

[0144] In some embodiments, the electronic tag can comprise a read-write RFID chip or other electronic device, which is used to record or change the ID information of the second slide box, and the user can locate and search for the saved slide sample according to the ID information.

[0145] In some embodiments, the information in the electronic tag can be repeatedly deleted and rewritten, so as to record the characteristics and / or index information of the saved slide in the slide box.

[0146] Optionally, the system further comprises:

[0147] a storage device for storing the characteristic information of the second slide box, and / or the index information, storage location information, characteristic information of the sample, and / or detection result of the sample of each measured slide in the second slide box.

[0148] In this way, the storage device can comprise a database system for storing the ID information of the second slide box and the corresponding position information, as well as the index information, storage location information, characteristic information of the sample, and / or detection result of the sample of the slide in each second slide box. The storage device can also comprise retrieval software, which can retrieve the slide that needs to be searched by using the ID information of the second slide box or the index information, characteristic information of the sample, etc. of the slide.

[0149] In some embodiments, after the measured slide is photographed on the detection platform, the imaging device obtains the cell image of the measured slide, the control device determines the specific storage location of the measured slide in the preset area according to the sample attribute of the measured slide, and the control device controls the slide unloading device to unload the measured slide to the specific storage location; meanwhile, the ID information of the measured slide, the cell image, and the specific storage location in the second slide box, and the ID information of the second slide box are stored in the storage device in association. Further, all the relevant information of the measured slide before detection can also be stored in association with the cell image and the location information in the second slide box, and the ID information of the second slide box according to the ID information of the measured slide.

[0150] In some embodiments, when the user needs to find the measured slide P (i.e., at least one index information S of the measured slide P is known), the information S can be searched in the database system, and then the location L of the measured slide P stored in the second slide box Q can be obtained; the user can quickly locate the second slide box Q through the manual label on the second slide box Q, so as to find the measured slide P; after the user quickly locates the second slide box Q through the manual label on the second slide box Q, a handheld reading device can be used to read the information of the loaded slide recorded in the electronic label in the second slide box Q, to determine whether the specific location of the measured slide P is L, and then find the measured slide P according to the specific location. It should be understood that the user can set the manual label and the electronic label at the same time, combine the advantages of intuitive and easy finding of the manual label and storage of the sample information of each slide in the electronic label, and improve the storage, management, and query efficiency of the slide.

[0151] Optionally, the system has a counting component for counting the number of measured slides in the second slide box.

[0152] In some embodiments, the number of measured slides in the second slide box can be counted by counting the number of ID information of the slides related to the second slide box in the storage device.

[0153] In some embodiments, the number of measured slides in the second slide box can be counted by counting the number of actions of the slide unloading device.

[0154] In some embodiments, the number of measured slides in the second slide box can be counted by detecting whether each accommodation space is placed with a slide, and counting the number of accommodation spaces placed with a slide.

[0155] Optionally, the system further comprises a prompting device for prompting the user to replace the second slide cassette when the number of the measured slides in at least one of the preset regions reaches a preset threshold.

[0156] In some embodiments, when the counting component counts that the number of the slide-holding spaces in a preset region reaches the number of the slide-holding spaces in the preset region, i.e. the preset region is full, the user can be prompted to replace the second slide cassette. Alternatively, in order to maximize the use of the second slide cassette to store the measured slides, the user can not be prompted when the preset region is full, because at this time, other preset regions can still be used. If the next measured slide belongs to other preset regions, it can be placed in other preset regions. However, if the next measured slide still belongs to the preset region that is full, the user can be prompted to replace the second slide cassette at this time.

[0157] In some embodiments, the prompting device can use voice prompts and / or indicator light prompts, which are not limited herein.

[0158] Optionally, the system further comprises a detection device for detecting whether the second slide cassette is placed in a predetermined position before the measured slides are loaded into the second slide cassette.

[0159] In some embodiments, the detection device comprises a sensor that can detect whether the second slide cassette is placed in the predetermined position.

[0160] Optionally, the prompting device is further used to prompt the user that the second slide cassette is not placed when the detection device detects that the second slide cassette is not placed in the predetermined position.

[0161] In some embodiments, when the cell image analysis system is started, or when or before the measured slides need to be unloaded into the second slide cassette, if it is detected that the second slide cassette is not placed in the predetermined position, the prompting device can use voice prompts, such as voice playing "the second slide cassette is not placed"; can use indicator light prompts, such as indicator light on or flashing to indicate that the second slide cassette is not placed; can use voice and indicator light prompts at the same time, which are not limited herein.

[0162] Optionally, the system further has a display component for displaying the position in the second slide cassette where the measured slides have been loaded and / or the number of the measured slides in the second slide cassette.

[0163] In some embodiments, the display component can be a display screen. In some embodiments, the distribution image of the second slide cassette can be displayed on the display screen, and different colors can be used to distinguish the parts of the second slide cassette that have been loaded with the measured slides and the parts of the second slide cassette that have not been loaded with the slides. Further, the position information corresponding to each holding space can also be displayed simultaneously. See Figure 16 , Figure 16 An example of displaying the second slide cassette in the display component according to an embodiment of the present application is shown. Figure 16 In some embodiments, the second slide cassette can be divided into a preset area A, a preset area B, and a preset area C. A first color (e.g., green, not shown) and / or a first symbol (e.g., “O” or “V”) can be used to indicate that the holding space has been loaded with the slides, and a second color (e.g., yellow, not shown) and / or a second symbol (e.g., “A” or “X” or no mark) can be used to indicate that the holding space has not been loaded with the slides. Thus, in the preset area A of the second slide cassette, the first column of the first row and the first column of the second row have been loaded with the measured slides, and in the preset area B of the second slide cassette, the second column of the first row, the second column of the second row, and the second column of the third row have been loaded with the measured slides. Further, the number of the slides loaded in the second slide cassette can also be displayed, such as 5 / 20 (i.e., 5 slides have been loaded in the second slide cassette out of a total capacity of 20). The number of the slides loaded in each preset area of the second slide cassette can also be displayed, such as preset area A: 2 / 6 (i.e., 2 slides have been loaded in the preset area A out of a total capacity of 6), preset area B: 3 / 6 (i.e., 3 slides have been loaded in the preset area B out of a total capacity of 6), and preset area C: 0 / 8 (i.e., 0 slide has been loaded in the preset area C out of a total capacity of 8).

[0164] Optionally, the system further comprises an identification device 280 configured to identify an electronic identification mark in the slide to be measured or the measured slide to obtain the identity information of the slide to be measured or the measured slide.

[0165] In some embodiments, the electronic identification mark in the slide to be measured or the measured slide can include, but is not limited to, a barcode and / or a radio frequency identification tag.

[0166] In some embodiments, the identity information of the slide to be measured or the measured slide can include, but is not limited to, a serial number (ID) of the slide to be measured or the measured slide, and / or a source of the slide to be measured or the measured slide (e.g., a department from which the slide to be measured or the measured slide originates, and / or a patient from which the slide to be measured or the measured slide originates, etc.).

[0167] Specifically, the detection or analysis of the sample in the slide to be measured can be based on the barcode or the radio frequency identification tag on the slide to be measured to obtain the relevant information of the sample, such as the information of the patient, the operation information of the slide to be measured, etc. In some embodiments, the relevant information of the sample includes, but is not limited to, the personal information of the patient, the barcode information of the sample. The personal information of the patient can include the name, the patient number, the height, the weight, etc.

[0168] According to an embodiment of the present application, a cell image analysis system comprises:

[0169] a control device;

[0170] a slide loading device configured to load a slide to be tested onto a testing platform;

[0171] the testing platform configured to carry the slide to be tested for testing;

[0172] an imaging device configured to take pictures of cells of a sample in the slide to be tested on the testing platform, the slide to be tested after taking pictures being a tested slide;

[0173] a slide unloading device configured to unload the tested slide from the testing platform into a recycling slide box;

[0174] the recycling slide box configured to load the tested slide, and the recycling slide box configured to accommodate at least 20, 40, 60, 80, or 100 slides.

[0175] Optionally, the recycling slide box is provided with a plurality of preset areas according to sample attributes, and the control device controls the slide unloading device to move the tested slide into the preset area corresponding to the sample attribute of the tested slide; wherein the sample attributes include sample information, pathological information, patient characteristics, testing time, or sample collection source.

[0176] Optionally, the control device controls the slide unloading device to place the tested slide in the recycling slide box at a preset interval.

[0177] Optionally, the recycling slide box is provided with an elastic device configured to fix the tested slide placed in the recycling slide box.

[0178] Optionally, the recycling slide box comprises an identification part, the identification part comprising a manual label and / or an electronic label, the manual label and / or the electronic label configured to record characteristic information of the recycling slide box; wherein the electronic label is further configured to record index information, storage location information, and characteristic information of a sample and / or detection results of the sample of each tested slide in the recycling slide box.

[0179] Optionally, the system further comprises:

[0180] a storage device configured to store the characteristic information of the recycling slide box, and / or the index information, storage location information, and characteristic information of a sample and / or detection results of the sample of each tested slide in the recycling slide box.

[0181] Optionally, the system further comprises:

[0182] a counting component configured to count the number of the measured slides in the recycling slide cassette;

[0183] a display component configured to display the position in the recycling slide cassette where the measured slides have been loaded and / or the number of the measured slides in the recycling slide cassette.

[0184] Optionally, the system further comprises a prompting device configured to prompt a user to replace the recycling slide cassette when the number of the measured slides in at least one of the preset regions reaches a preset threshold.

[0185] Optionally, the system further comprises a detecting device configured to detect whether the recycling slide cassette is placed to a predetermined position before the measured slides are loaded into the recycling slide cassette, and the prompting device prompts the user that the recycling slide cassette is not placed when the detecting device detects that the recycling slide cassette is not placed to the predetermined position.

[0186] It should be understood that the components included in the cell image analysis system shown above are only illustrative, and the present application is not limited thereto.

[0187] Figures 17 to 19 A perspective view of a second slide cassette or recycling slide cassette 270 provided by an embodiment of the present application is shown.

[0188] As Figure 17 and Figure 18 described above, the recycling slide cassette 270 has a housing 12 and a plurality of slots 114 for accommodating slides 10 arranged in the housing 12. In the current embodiment, the recycling slide cassette 270 has 60 slots or recycling storage slots 114, and can recycle and store 60 slides 10.

[0189] The housing 12 includes four side portions (i.e., two opposite left and right sides and two opposite front and back sides), a top portion, and a bottom portion. The housing 12 has a first side plate 1110 and a second side plate 1120 on the two opposite first side portions 1210 (i.e., the two opposite left and right sides) respectively. Figure 17 Figure 18 Each slot 114 is formed by a first support portion 1141 on the first side plate 1110 and a second support portion 1142 on the second side plate 1120 opposite to the first support portion 1141.

[0190] The first side plate 1110 and the second side plate 1120 are detachably mounted on the inner side of the corresponding first side portion 1210 of the housing 12, for example. Of course, in other embodiments, the first side plate 1110 and the second side plate 1120 may, for example, also be integrated on the inner side of the corresponding first side portion 1210 of the housing 12.​

[0191] The housing 12 has an opening, i.e. a first opening 1220 and a second opening (not shown in the figure), on each of the two second sides (front and back sides) for the slide 10 to go in and out of the slot 114, so that the second slide box, or the recycling slide box 270, is accessible from the front and the back, and the recycled slide 10 can be inserted or taken out from the front to the back or from the back to the front. By providing openings on both the front and the back of the recycling slide box 270, it is convenient for the user to search and clean the slides.

[0192] In the preferred embodiment, the length of each recycling storage slot 114 is less than the length of the slide. It is particularly preferred that the length of each recycling storage slot 114 is less than the length of the label area (i.e. the slide label information printing area) of the slide, so as to ensure that the slide label information printing area is not covered by the slot, and the mirror oil dropped on the slide will not contaminate the slide label information printing area, thereby avoiding contamination of the user's hands when searching for the slide.

[0193] In addition, in order to facilitate the user to take and place the recycling slide box 270, the housing 12 has a handle 121 on the top 1230 thereof.

[0194] Further, as shown in Figures 17 to 19 , anti-slip recesses 122 are provided on the left and right outer sides (i.e. the outer sides of the first side 1210 where the side plates are located) of the housing 12, for the user to take the recycling slide box 270 from the side.

[0195] When recycling the slide, the recycling slide box 270 is accommodated in the accommodation seat 3 provided in the cell image analysis system, as shown in Figure 20 . In order to facilitate the placement of the recycling slide box 270 in the accommodation seat 3, the recycling slide box 270 has a fool-proof design, as shown in Figure 19 and Figure 20 , a guide groove 123 is provided on one of the first sides 1210 of the housing 12 (here, the left outer side), which cooperates with the guide bar 38 provided in the accommodation seat 3 to guide the recycling slide box 270 into the accommodation seat 3. In addition, recesses 124 are provided on both sides of the guide groove 123, which cooperate with the ball plunger 37 provided in the accommodation seat 3 to fix and position the recycling slide box 270 in the accommodation seat 3. In this way, the recycling slide box 270 can be accurately positioned in the accommodation seat 3, and the user's misuse can be prevented.

[0196] Further, as shown in Figure 19 and Figure 20As shown, a fixing device 125 is arranged at the bottom of the recycling slide box 270, which cooperates with the suction device 32 arranged in the bottom of the accommodating cavity of the accommodating seat 3. When the suction device 32 cooperates with the fixing device 125, the recycling slide box 270 is fixed on the accommodating seat 3, and at this time, the user cannot take the recycling slide box 270 out of the accommodating seat 3.

[0197] In addition, in Figure 20 In the embodiment shown, the accommodating seat 3 further comprises an identification part 33 for detecting whether the recycling slide box 270 is placed in the accommodating seat 3.

[0198] After the recycling slide box is repeatedly used for a period of time, a large amount of oil stains will be left in the recycling slide box, causing oil stain pollution, and the user needs to frequently change gloves, resulting in an increase in cost. Therefore, the embodiment of the present application proposes a brand-new oil guiding and collecting system.

[0199] In the oil guiding and collecting system proposed in an embodiment of the present application, at least one oil guiding groove 112 is arranged in at least one of the first side plate 1110 and the second side plate 1120 of the shell. As Figure 21 As shown, Figure 21 A perspective view of the first side plate 1110 of an embodiment of the present application is shown, and the oil guiding groove 112 is arranged in the first side plate 1110.

[0200] Preferably, at least one oil guiding groove 112 is arranged in each of the first side plate 1110 and the second side plate 1120. Further preferably, the oil guiding groove arranged in the first side plate 1110 is asymmetrically arranged with the oil guiding groove arranged in the second side plate 1120, so as to ensure that the slide is smoothly recycled into the slot 114.

[0201] Preferably, as Figure 21 As shown, all the slots 114 are penetrated by the oil guiding groove 112 from top to bottom, so that the lens oil in the slot 114 is guided along the oil guiding groove 112, especially to the bottom 1240 of the shell 12. That is, the at least one oil guiding groove 112 is configured to penetrate the support part of each slot 114 on the side plate where the at least one oil guiding groove is located, for example, the middle support part. For example, in Figure 21 As shown in the embodiment, the oil guiding groove 112 arranged in the first side plate 1110 penetrates the first support part 1141 of each slot 114. In the case that the oil guiding groove is arranged in the second side plate 1120, the oil guiding groove of the second side plate 1120 can penetrate the second support part 1142 of each slot 114.

[0202] As Figure 21As shown, the oil guiding groove 112 extends at least from the uppermost slot 114' of the plurality of slots, for example, vertically to the vicinity of the bottom 1240 of the housing 12, and penetrates the first support portion 1141 of each slot 114. Preferably, the oil guiding groove 112 extends at least from the uppermost slot 114' of the plurality of slots obliquely (i.e. at an angle to the vertical direction) to the vicinity of the bottom 1240 of the housing 12, thereby enabling the slides to be smoothly recovered into the slide recovery box 270 without being stuck in the slots 114.

[0203] In some embodiments, at least one first oil guiding groove 111 is formed in at least one of the first side plate 1110 and the second side plate 1120, and at least one second oil guiding groove 112 is formed in at least one of the first side plate 1110 and the second side plate 1120, the at least one first oil guiding groove 111 extending near the side edge of the side plate in which it is formed and not penetrating the support portion of each slot, and the at least one second oil guiding groove 112 penetrating the support portion of each slot in the side plate in which it is formed.

[0204] In some embodiments, at least one first oil guiding groove 111 is formed in at least one of the first side plate 1110 and the second side plate 1120, and at least one second oil guiding groove 112 is formed in at least one of the first side plate 1110 and the second side plate 1120, the at least one first oil guiding groove 111 extending near the side edge of the side plate in which it is formed and not penetrating the support portion of each slot, and the at least one second oil guiding groove 112 penetrating the support portion of each slot in the side plate in which it is formed. Figure 21 In the illustrated embodiment, the first oil guiding groove 111 and the second oil guiding groove 112 are formed in the first side plate 1110. The first oil guiding groove 111 extends in front of the slots 114 near the front side edge of the first side plate 1110, from the underside of the top 1230 of the housing 12 to the vicinity of the bottom 1240 of the housing 12, in particular to the oil storage portion 127 provided in the bottom 1240 of the housing 12, which can receive the oil stains guided down by the oil guiding grooves 111, 113 of the side plates for the user to clean. The second oil guiding groove 112 extends from the uppermost slot 114' to the vicinity of the bottom 1240 of the housing 12, in particular to the oil storage portion 127, and penetrates the first support portion 1141 of each slot 114.

[0205] Although Figure 21 Only the oil guiding structure of the first side plate 1110 is shown, but it can be understood that the second side plate 1120 can also have the same or similar oil guiding structure.

[0206] In addition, as Figure 21 As shown, the first side plate 1110 also has a clamping portion 113 for clamping the slide from the side in each slot 114, in particular an elastic clamping portion (e.g. a spring), which can protect the blood film applied on the upper side of the slide. It can be understood that, corresponding to the first side plate 1110, the second side plate 1120 also has a clamping portion 113 for clamping the slide from the side in each slot 114.

[0207] Preferably, the clamping portion 113 extends obliquely from the corresponding side plate towards the longitudinal axis of the slot 114. The oblique design, especially the large angle design, of the lateral clamping portion can provide assistance when cleaning the slides in the recycling box 270, facilitating the user to clean the slides. That is, the oblique design of the lateral clamping portion not only can effectively provide a lateral clamping force, but also can provide assistance from front to back when cleaning the slides in the recycling box 270 from front to back, making it easier to clean the slides. In addition, when the user takes out the recycling box that has completed recycling from the containing seat, even if the recycling box is turned upside down or tilted, the slides inside will not fall out.

[0208] Figure 22 A preferred design of the elastic clamping portion 113 is shown, each elastic clamping portion 113 extends obliquely from the corresponding side plate towards the longitudinal axis of the corresponding slot 114, and the oblique angle is about 40°.

[0209] Further, as shown in Figure 18 , in order to facilitate the user to find the recycled slides, the handle 121 has a label portion 128 for the user to distinguish different recycling boxes 270. In addition, the right side of the shell 12 has an information storage and identification portion 126, which stores the situation of the recycled slides in the recycling box 270. Accordingly, as shown in Figure 20 , the side plate 31 of the containing seat 3 is provided with an information identification module 36 (such as an RFID card reader), which is used in cooperation with the information storage and identification portion 126.

[0210] Therefore, the embodiment of the present application provides a large-capacity slide recycling box that can prevent oil, guide oil, collect oil, and quickly clean slides. In view of the defects of the existing slide recycling box, such as small capacity, inconvenient to find and clean slides, and residual oil stains, the embodiment of the present application greatly enhances the usability of the slide recycling box through the oil guide groove structure, the double-opening (slides can enter and exit in two directions) structure, and the two-side large-angle pressing slide structure.

[0211] Figure 23 A perspective view of a second slide box or a recycling slide box 300 provided by another embodiment of the present application is shown, which includes a box body 310 and a slot assembly 320 arranged in the box body 310. The box body 310 has a containing cavity 311. One side of the containing cavity 311 is provided with a slot insertion opening 312 for transversely inserting and taking out sample slides, and the other sides and the bottom of the containing cavity 311 are closed. The slot assembly 320 is arranged in the containing cavity 311, and the slot assembly 320 has at least one column of slot groups, and each slot group has at least two slots 321 for inserting sample slides 800. All slots 321 in each column of slot groups are transversely arranged and vertically stacked, and the entrances of the slots 321 are communicated with the slot insertion opening 312.

[0212] The mirror oil is usually located in the middle of the sample slide 800, and when the sample slide 800 on which the detection has been completed is inserted into the corresponding slot 321 from the insertion port 312, the middle is accommodated in the slot 321. Since the other sides and the bottom of the box body 310 are closed except the insertion port 312, even if the liquid on the sample slide 800 flows everywhere, most of the liquid will flow into the accommodation cavity of the box body 310, the outflow of the liquid can be reduced, the pollution to other equipment and instruments can be avoided, and the inconvenience of the operator can be reduced.

[0213] Please refer to Figures 23 to 25 In an embodiment, the box body 310 has a bottom shell 314, a top shell 315, and a side shell 313 connected between the bottom shell 314 and the top shell 315. The bottom shell 314, the top shell 315, and the side shell 313 surround the accommodation cavity 311, and the insertion port 312 is located on one side of the side shell 313. The box body 310 can be generally square as a whole, three of the four sides of the box body 310 are closed, and only one side is used to set the insertion port 312.

[0214] Please refer to Figure 26 The side of the accommodation cavity 311 on which the insertion port 312 is located is the outer side, and the side opposite to the outer side is the inner side. In order to further reduce the outflow of the mirror oil and the like, in an embodiment, the slot assembly 320 has a limiting structure, and the limiting structure forms a slide insertion channel on the slot 321, which is arranged obliquely downward from the outer side to the inner side, so as to make the sample slide 800 be arranged obliquely downward from the outer side to the inner side in the slot 321. As shown in FIG. 5, the sample slide 800 is inserted into the slot 321 from right to left. The front end 801 of the sample slide 800 is on the left side of the drawing, and the front end 801 is located on the inner side of the accommodation cavity 311. The rear end 802 of the sample slide 800 is on the right side of the drawing, and the rear end 802 is located on the outer side of the accommodation cavity 311. At this time, the front end 801 of the sample slide 800 is lower than the rear end 802, so as to guide the mirror oil and the like to flow to the front end 801, and further guide the liquid to flow more to the inside of the accommodation cavity 311 of the box body 310, rather than to the side of the accommodation cavity 311 of the insertion port 312, so as to further reduce the outflow of the liquid to the outside of the recovery slide box 300.

[0215] The slide insertion channel refers to the movable space of the sample slide 800 in the box body 310 after the sample slide 800 is stored in the box body 310, that is, the sample slide 800 can only move in the slide insertion channel. The box body 310 has the slot 321, and the slide insertion channel can include all or part of the slot 321, for example, a part of the slot 321 and other components (such as the lower pressing member or the upper top member described below) form a slide insertion channel for accommodating the sample slide 800.

[0216] In one embodiment, the limiting structure comprises a pressing member 322, which has a pressing portion 3221 for pressing one end of the sample slide 800 from above, so as to make the sample slide 800 be obliquely arranged from the outside to the inside in the slot 321. Generally, the pressing member 322 mainly presses the front end 801 of the sample slide 800 downward, and of course, in some embodiments, the pressing member 322 can also press other positions of the sample slide 800, as long as the front end 801 of the sample slide 800 is lower than the rear end 802.

[0217] The pressing member 322 can be arranged in the slot 321 or outside the slot 321. Referring to FIG. 5, in one embodiment, the slot 321 has an inlet at one end towards the insertion opening 312, and an outlet at the other end away from the insertion opening 312, and the inlet and the outlet are arranged in a penetrating manner. The front end 801 of the sample slide 800 extends out of the outlet. The pressing portion 3221 is located outside the outlet, and presses the part of the sample slide 800 extending out of the outlet, i.e. presses the front end 801 of the sample slide 800. In this embodiment, due to the limiting effect of the pressing member 322, the sample slide 800 can only move in a part of the space in the slot 321, and this part of the space and the passing space defined by the pressing member 322 are one of the components of the slide insertion channel.

[0218] In this embodiment, the pressing portion 3221 is lower than the upper wall 323 of the corresponding slot 321 and higher than the lower wall 324, so as to finally define a space in the slot 321 for the oblique arrangement of the sample slide 800 downward.

[0219] Referring to FIG. 5, Figure 26 In one embodiment, the pressing member 322 is arranged obliquely, wherein the pressing member 322 has a first end 3222 towards the insertion opening 312, and a second end 3223 away from the insertion opening 312, and the pressing portion 3221 is located at the second end 3223 of the pressing member 322. The first end 3222 of the pressing member 322 is higher than the second end 3223, so that when the sample slide 800 is inserted, the first end 3222 of the pressing member 322 facing the sample slide 800 forms a guide opening gradually narrowing from right to left, which facilitates the insertion of the sample slide 800 below the corresponding pressing member 322 and guides the sample slide 800 to move towards the second end 3223 of the pressing member 322.

[0220] Of course, the above-mentioned pressing member 322 is only one of the means for achieving the oblique arrangement of the sample slide 800. In another embodiment, the limiting structure comprises an upper lifting member (not shown in the figure), which is used for lifting one end of the sample slide 800 from below, so as to make the sample slide 800 be obliquely arranged from the outside to the inside in the slot 321.

[0221] The upper lifting member generally lifts the back end 802 of the sample slide 800. Of course, in some embodiments, the upper lifting member can also lift other positions of the sample slide 800, as long as the front end 801 of the sample slide 800 is lower than the back end 802.

[0222] The upper lifting member has an upper lifting portion for lifting the sample slide 800. Similar to the lower pressing member 322, the upper lifting member can be arranged inside the slot 321 or outside the slot 321. In one embodiment, the upper lifting portion is arranged outside the slot 321, and is used to lift the portion of the sample slide 800 outside the slot 321, i.e. the back end 802 of the sample slide 800.

[0223] The above-mentioned lower pressing member 322 and upper lifting member can be mounted on the slot assembly 320 or the box body 310. The lower pressing member 322 and upper lifting member can be used separately or in combination. The upper lifting member and lower pressing member 322 can be arranged inside the slot 321 or outside the slot 321, or one of them is arranged inside the slot 321 and the other is arranged outside the slot 321.

[0224] In one embodiment, the upper lifting member and lower pressing member 322 are partially or entirely made of elastic material, so that the upper lifting member and lower pressing member 322 have certain self-adapting adjustment characteristics when they contact the sample slide 800, avoiding hard contact between them and the sample slide 800. Of course, in other embodiments, the upper lifting member and lower pressing member 322 can also be made of non-elastic material.

[0225] In addition, in another embodiment, the slot 321 includes an upper slot wall 323 and a lower slot wall 324, wherein at least the lower slot wall 324 is arranged to be inclined downward from the outside to the inside, forming a limiting structure. After the sample slide 800 is inserted into the slot 321, it is arranged along the inclined surface of the lower slot wall 324 under the action of gravity, so that the front end 801 of the sample slide 800 is lower than the back end 802.

[0226] In this embodiment, the upper slot wall 323 can be an inclined surface in the same direction as the lower slot wall 324, of course, it can also be arranged horizontally, or even be an inclined surface (in the opposite direction) opposite to the lower slot wall 324, and the shape of the upper slot wall 323 is not limited here.

[0227] In addition to the above various structures, the limiting structure can also be other types of structures to make the sample slide 800 be arranged obliquely and guide the liquid on it to flow to the front end 801.

[0228] Further, please refer to Figure 26 and 27In one embodiment, the slot 321 comprises an upper slot wall 323 and a lower slot wall 324, and the middle part of the upper slot wall 323 and the lower slot wall 324 of all the slots 321 in the same column are left empty to communicate all the slots 321 in the same column, and the limiting structure is located at the left empty part 325. The left empty part 325 can facilitate the arrangement of the limiting structure, and also facilitate the flow of liquid such as mirror oil to the bottom wall of the accommodating cavity 311, avoiding more liquid remaining on the upper slot wall 323 and the lower slot wall 324, and also facilitating the observation of the sample slide 800 in the slot 321.

[0229] On the other hand, in order to further reduce the situation that the liquid such as mirror oil flows out of the box body 310, please refer to FIG. 6, in one embodiment, the accommodating cavity 311 has a liquid storage groove 317, which is used to collect the liquid flowing from the sample slide 800, and further reduce the situation that the liquid flows out of the recovery slide box 300.

[0230] In one embodiment, the liquid storage groove 317 is arranged on the bottom wall of the accommodating cavity 311, and the liquid collected from various parts of the accommodating cavity 311 finally flows to the bottom wall of the accommodating cavity 311 and is temporarily stored in the liquid storage groove 317.

[0231] In one embodiment, at least one liquid storage groove 317 is arranged below each column of slot groups. The liquid storage groove 317 can be a reverse T shape, the vertical segment 3171 of the reverse T shape liquid storage groove 317 extends into the corresponding slot group, and the horizontal segment 3172 of the reverse T shape liquid storage groove 317 is located outside the slot group. When the slot group is more than two, the horizontal segments 3172 of the liquid storage grooves 317 of adjacent slot groups are communicated with each other, so that the liquid of all the slot groups can be collected at the horizontal segment 3172, to facilitate subsequent processing of the liquid.

[0232] In Figure 27 , the liquid storage groove 317 is recessed on the bottom wall of the accommodating cavity 311. In other embodiments, the liquid storage groove 317 can also be formed by the inclined arrangement of the bottom wall, for example, the end of the inner side of the bottom wall is inclined, thereby forming a liquid storage groove 317 with the side of the box body 310 on the inner side of the accommodating cavity 311.

[0233] Further, the number of slot groups can be flexibly arranged according to the recovery demand and the space demand, as shown in FIG. 1, in one embodiment, the slot group is a group. As Figures 22 to 23 shown, in one embodiment, the slot assembly 320 has at least two column of slot groups, and all the slot groups are arranged side by side in the accommodating cavity 311 of the box body 310.

[0234] Further, no matter one group or more than two groups of slot groups are adopted. In an embodiment, the outer wall of the box body 310 has a readable unit 331 representing the identity information of the recycled slide box 300. The readable unit 331 is a series of components capable of transmitting identity information, such as radio frequency identification tags, two-dimensional codes, bar codes, etc. The identity information can be unique. By identifying the readable unit 331, the identity of the current recycled slide box 300 can be recorded, and which sample slides 800 are placed in the recycled slide box 300 can be recorded, so that when a certain sample slide 800 needs to be queried later, its location in which recycled slide box 300 can be determined according to the recorded information.

[0235] Of course, in order to more accurately determine the position of the sample slide 800, in an embodiment, the box body 310 or the slot assembly 320 is provided with guide information 322 for showing the serial number of the slot 321. As shown in FIG. 6, the guide information 322 is provided on the slot assembly 320. The guide information 322 can be numbers or other forms of information, as long as it can show the sequence position of each slot 321. The guide information 322 can be provided separately for each slot 321, or can be provided at intervals of a certain number of slots 321.

[0236] According to the embodiment of the present application, a slide storage method of a cell image analysis system is also provided, which is described with reference to Figure 28 , Figure 28 A schematic flowchart of the slide storage method of the cell image analysis system according to the embodiment of the present application is shown. As shown in Figure 28 , the method 1700 comprises:

[0237] Step S1710, sequentially obtaining the to-be-tested slides from the first slide box and loading them onto the detection platform;

[0238] Step S1720, detecting the samples in the to-be-tested slides on the detection platform, and the to-be-tested slides that have been detected are measured slides;

[0239] Step S1730, according to the sample properties of the measured slides, unloading the measured slides from the detection platform to the corresponding area in the plurality of preset areas of the second slide box, wherein the plurality of preset areas are set by a user according to sample properties;

[0240] The second slide box loads the measured slides from a plurality of the first slide boxes.

[0241] According to the embodiment of the present application, in step S1730, according to the sample properties of the measured slides, the measured slides are unloaded from the detection platform to the corresponding area in the plurality of preset areas of the second slide box, comprising:

[0242] acquire position information of a corresponding region in the plurality of preset regions of a sample attribute of the measured slide;

[0243] move the measured slide into the corresponding region according to the position information, and place the measured slide in the second slide box with a preset interval.

[0244] In order to facilitate the user to find the slide, according to the embodiment of the application, when the measured slide is unloaded into the second slide box, the slide can be classified according to the information associated with the sample in the slide and placed in different preset regions. The same type of slide can be placed in the same preset region, which is convenient for the classification and long-term storage of the slide and is also conducive to the search of the sample.

[0245] In some embodiments, the preset region can be set according to the sample attribute, and the sample attribute includes sample information, pathological information (such as disease type), patient characteristics, detection time or sample collection source (such as the department where the sample is collected).

[0246] Specifically, after the imaging device photographs the slide, the control device determines the preset region to which the measured slide belongs and the specific position at which the measured slide is to be placed in the preset region according to the sample attribute of the measured slide, and controls the slide unloading device to move the measured slide to the second slide box according to the specific position; as described above, the interval between the measured slide placed in the second slide box and the slide can be set by the user. At this time, the slide unloading device determines the placement direction of the measured slide based on the direction of the second slide box, and unloads the measured slide into the second slide box according to the placement interval set by the user.

[0247] Optionally, the second slide box is replaced and directly used as a storage container when a preset time period elapses or when the number of measured slides in at least one of the preset regions in the second slide box reaches a preset threshold.

[0248] If the capacity of the second slide box can meet the capacity of all detected slides within a period of time (such as one day), the user can choose to replace the second slide box only at a preset time or at a fixed time (such as the end of each day), and directly move it to a dedicated slide storage space for long-term storage. This not only saves the process of frequently replacing the second slide box during the detection of multiple first slide boxes, but also saves the process of transferring the measured slides in the second slide box to a long-term storage container, greatly saving the user's work flow and improving the storage efficiency of the slide.

[0249] Optionally, the second slide box has an electronic tag, and the method further comprises:

[0250] The feature information of the second slide box, the index information of each measured slide in the second slide box, the storage location information, and the feature information of the sample and / or the detection result of the sample are stored in the electronic tag.

[0251] Optionally, the method further comprises:

[0252] Reading the electronic tag of the second slide box to obtain the index information of each measured slide;

[0253] According to the index information of the to-be-searched slide, searching in the index information of each measured slide to obtain the storage location information of the to-be-searched slide;

[0254] According to the storage location information of the to-be-searched slide, taking out the to-be-searched slide from the second slide box.

[0255] In some embodiments, the working process of the cell image analysis system according to the embodiments of the present application is described.

[0256] The user performs cell image analysis on the to-be-tested slides in different first slide boxes at different times. It is assumed that the user tests the to-be-tested slides in a first slide box with a capacity of C1 in a day,

[0257] First, the user starts the cell image analysis system. At this time, it can be detected whether the second slide box is in the predetermined position. If the second slide box is not in the predetermined position, the user is prompted. If the second slide box is already in the predetermined position, the detection of each slide is started;

[0258] Then, for each first slide box, the user issues a detection instruction through the operation system;

[0259] Then, after receiving the detection instruction, the control device controls the mechanical arm in the slide loading device to sequentially clamp the to-be-tested slides from the first slide box located on the side of the imaging device or the detection platform, and can load the to-be-tested slides to the detection platform directly (or indirectly through the slide input module) through at least one of horizontal movement, vertical movement, and turning. At the same time, the identification module can identify the electronic identification mark in the to-be-tested slide to obtain the identity information (such as the ID information of the slide) of the to-be-tested slide;

[0260] Then, the imaging device located above the detection platform photographs the cells in the specific region of the to-be-tested slide according to the photographing conditions set by the user to obtain the cell image of the to-be-tested slide. The to-be-tested slide after photographing is recorded as a measured slide;

[0261] Then, the control device determines, according to the sample attribute of the to-be-tested slide, which preset area in the second slide box the to-be-tested sample should belong to and which containing space, i.e., specific storage location, the to-be-tested sample should be placed in;

[0262] Then, the control device controls the mechanical arm in the slide unloading device to unload the tested slide on the detection platform directly (or indirectly through the slide output module) to the specific storage location in the corresponding preset area in the second slide box with a capacity of C2 according to the specific storage location;

[0263] Then, the identity information of the tested slide, the photographed cell image, the detection time, the ID information of the second slide box, and the specific location information of the tested slide in the second slide box can be stored in the storage device in association, and the number of the tested slides in the second slide box in the technical unit of the system is increased by 1, and the area corresponding to the tested slide in the second slide box schematic diagram displayed by the display component is changed from the second symbol to the first mark to indicate that the area is loaded with the tested slide.

[0264] Then, if the second slide box is full of tested slides according to the counting of the counting unit, the prompting device prompts the user to replace the second slide box; the user can hold the handle arranged on one side of the second slide box full of tested slides, take the second slide box out of the cell image analysis system, and directly place the second slide box in a special storage area to store the tested slides for a long time; wherein, if the capacity C2 of the second slide box is greater than or equal to C1*a, i.e., the second slide box can meet the number of tested slides in one day, at this time, whether the second slide box is full or not, the user can replace the second slide box after the detection ends in the day and take the second slide box out as a long-term storage container.

[0265] Then, when the user needs to retest one or more tested slides, the ID information of the second slide box in which the tested slide is located, the storage location of the second slide box, and the storage location of the tested slide in the second slide box can be obtained by searching the index information of all the second slide boxes in the database according to the relevant information of the tested slide, so that the tested slide can be directly and accurately found.

[0266] The embodiment of the application further provides a computer readable storage medium storing a plurality of program instructions, which, when called and executed by a processor, can execute part or all of the steps or any combination of the steps in the cell image analysis and slide storage method.

[0267] In exemplary embodiments, embodiments of the present invention further provide a computer-readable storage medium, such as a memory device including a computer program. The computer program can be executed by a processor of a cell image analysis system to perform the steps of the aforementioned method. The computer-readable storage medium can be a memory device such as FRAM, ROM, PROM, EPROM, EEPROM, Flash Memory, magnetic surface mount storage, optical disk, or CD-ROM. It can also be various devices including any one or any combination of the aforementioned memory devices, such as a portable analyzer.

[0268] In summary, according to the cell image analysis system and slide storage method of the embodiments of the present invention, by directly placing the tested slides into a large-capacity slide box for long-term storage, not only the number of times the user frequently replaces the slide box is greatly reduced, and the slide blockage caused by the full slide box is avoided, but also the large-capacity slide box is directly used for long-term storage, and the tested slides do not need to be manually transferred to the long-term storage container, which greatly improves the storage efficiency of the slides.

[0269] Those skilled in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professionals and technicians can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of the present invention.

[0270] In the several embodiments provided in this application, it should be understood that the disclosed devices and methods can be implemented in other ways. For example, the device embodiments described above are merely illustrative. For example, the division of the units described is merely a logical function division. In actual implementation, other division methods may be used, such as combining or integrating multiple units or components into another device, or ignoring or not performing some features.

[0271] In the description provided herein, numerous specific details are described. However, it is understood that embodiments of the present invention may be practiced without these specific details. In some instances, well-known methods, structures, and techniques are not shown in detail so as not to obscure the understanding of this description.

[0272] Similarly, it is to be understood that the embodiments of the present application can be altered, combined, or modified and constitute modifications and variations of the example embodiments set forth herein that are within the scope of the present application. It is intended that the application(s) encompass each of the alternative of various embodiments as well as any and all equivalents. Therefore, to apprise the public of the various embodiments of the present application, this specification must be regarded as a breadth of disclosure of the application(s) rather than a limitation of the application(s).

[0273] Those skilled in the art will appreciate that all features described herein (including all features and processes described in connection with the accompanying claims, abstract and drawings) can be combined in any combination. Unless specifically stated otherwise, each feature disclosed in this specification (including any accompanying claims, abstract and drawings) can be replaced by alternative features that serve the same, equivalent or a similar purpose.

[0274] Furthermore, those skilled in the art will recognize that references in the specification to "one embodiment", "an embodiment", "an example embodiment", mean that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment of the application. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily referring to the same embodiment.

[0275] It should be noted that the above-mentioned embodiments illustrate rather than limit the application, and that one skilled in the art will be able to design many alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word "comprising" does not exclude the presence of elements or steps other than those listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The application can be implemented by means of both hardware and software, and any combination thereof. In a unit claim, any reference signs placed between parentheses shall not be construed as limiting the claim. The use of the word "about" followed by a value and / or a unit of measure to describe a criterion is intended to indicate that the criterion is up to + / - 10 % of the nominal value supplied non-limitatively in the description. The word "comprising" does not exclude the presence of elements or steps other than those listed in a claim. The word "a" or "an" preceding an element does not exclude the presence of a plurality of such elements. The application can be implemented by means of both hardware and software, and any combination thereof. In a unit claim, any reference signs placed between parentheses shall not be construed as limiting the claim. The use of the word "about" followed by a value and / or a unit of measure to describe a criterion is intended to indicate that the criterion is up to + / - 10 % of the nominal value supplied non-limitatively in the description.

[0276] The above merely describes specific embodiments or specific implementation of the present application, and the protection scope of the present application is not limited thereto, any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. The protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A cell image analysis system, characterized in that: The system comprises: A first slide box is used to load slides to be tested, wherein the slides in the first slide box are placed vertically; control devices; a slide loading device, wherein the control device controls the slide loading device to load the slide to be tested in the first slide box onto the detection platform; The detection platform is used to carry the glass slide to be tested for testing; An imaging device, wherein the control device controls the imaging device to photograph the cells of the sample in the to-be-tested glass slide on the detection platform, and the to-be-tested glass slide that has completed photographing is referred to as a tested glass slide; a slide unloading device, wherein the control device controls the slide unloading device to unload the tested slide from the detection platform into a second slide box; The second slide box is used to load the tested slides. The slides in the second slide box are placed horizontally, and the capacity of the second slide box is more than twice the capacity of the first slide box.

2. The system according to claim 1, wherein: The second slide box is provided with an elastic device, and the elastic device is used to fix the tested slide placed in the second slide box; and / or The second slide box includes an identification portion, and the identification portion includes a manual label and / or an electronic label, and the manual label and / or the electronic label are used to record characteristic information of the second slide box. Preferably, the electronic label is also used to record index information, storage location information, characteristic information of the sample and / or test results of each tested slide in the second slide box; and / or The second slide box is provided with a handheld device for holding; and / or An oil storage device is provided in the second slide box, and the oil storage device is used to collect the immersion oil of the measured slide in the second slide box; and / or The system comprises a counting component for counting the number of the measured slides in the second slide box; the system further comprises a display component for displaying the position of the measured slides in the second slide box and / or the number of the measured slides in the second slide box; and / or The system further includes a prompting device for prompting a user to replace the second slide box when the number of the measured slides in at least one of the preset areas reaches a preset threshold; and / or The system further includes a detection device for detecting whether the second slide box is placed in a predetermined position before the tested slide is loaded into the second slide box. When the detection device detects that the second slide box is not placed in the predetermined position, the prompting device prompts the user that the second slide box has not been placed.

3. The system according to claim 1 or 2, characterized in that The second slide box includes a plurality of adjacent accommodating spaces of adjustable number, and the plurality of adjacent accommodating spaces are arranged in a single row or in multiple rows.

4. The system according to any one of claims 1 to 3, characterized in that The capacity of the second slide box is at least 5 times the capacity of the first slide box; and / or The second slide box is configured to accommodate at least 40 slides; and / or The first slide box is configured to accommodate at least 10 slides.

5. The system according to any one of claims 1 to 4, characterized in that The second slide box has a shell and a plurality of slots arranged in the shell for accommodating slides. The shell has a first side panel and a second side panel on two opposite first side panels, and each slot is formed by a first supporting portion on the first side panel and a second supporting portion on the second side panel opposite to the first supporting portion.

6. The system according to claim 5, characterized in that At least one oil guide groove is formed in at least one of the first side plate and the second side plate.

7. The system according to claim 6, characterized in that At least one oil guide groove extends from at least the uppermost slot of the plurality of slots to near the bottom of the housing, preferably at least one oil guide groove extends obliquely from at least the uppermost slot of the plurality of slots to near the bottom of the housing; and / or At least one oil guide groove extends through the support portion of each slot located on the side plate where the at least one oil guide groove is located; and / or At least one first oil guide groove is formed in at least one of the first side plate and the second side plate, and at least one second oil guide groove is formed in at least one of the first side plate and the second side plate, wherein the at least one first oil guide groove extends in a side edge of the side plate in which it is located and does not pass through a supporting portion of each slot, and the at least one second oil guide groove passes through a supporting portion of each slot in the side plate in which it is located; and / or At least one first oil guiding groove is formed in the first side plate, and at least one second oil guiding groove is formed in the second side plate. The at least one first oil guiding groove and the at least one second oil guiding groove are arranged asymmetrically.

8. The system according to claim 6 or 7, characterized in that The length of each slot is less than the length of the slide; and / or The length of each slot is shorter than the length of the slide by at least the length of the label area of ​​the slide.

9. The system according to any one of claims 6 to 8, characterized in that The housing has openings on two opposite second side portions for slides to enter and exit the slot; and / or A lateral clamping portion is provided on the first side panel and the second side panel for each slot, and the lateral clamping portion is used to clamp the smear in the slot from the side of the smear. Preferably, each lateral clamping portion extends obliquely from the corresponding side panel toward the longitudinal axis of the corresponding slot, and the inclination angle is preferably about 40°.

10. A cell image analysis system, characterized in that: The system comprises: control devices; A slide loading device, used for loading the slide to be tested onto the detection platform along a first direction; The detection platform is used to carry the glass slide to be tested for testing; An imaging device is used to photograph the cells of the sample in the test slide on the detection platform, and the test slide that has completed the photographing is called the tested slide; a slide unloading device, configured to unload the tested slide from the detection platform into a slide recovery box along the first direction; The recycling slide box is used to load the tested slides, and the recycling slide box is configured to accommodate at least 20 slides.

Images