Preparation method of pH / pectinase dual stimulation response nano material

By preparing pH/pectinase dual-stimulation responsive nanomaterials, the problems of low precision and efficiency in drug delivery of traditional nanocarriers in the control of rice sheath blight have been solved. This has enabled precise release and efficient control of drugs in specific pathological environments, improving the control efficacy and safety of fungicides.

CN120814535APending Publication Date: 2025-10-21GUIZHOU UNIV
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Patent Information

Application Number
CN202510930290.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-07
Publication Date
2025-10-21

AI Technical Summary

Technical Problem

The existing fungicide PRO has not effectively solved the problems of loading, delivery and efficacy improvement in the control of rice sheath blight. Traditional nanocarriers have low precision and efficiency in drug delivery, which cannot meet the needs of efficient control of rice sheath blight.

Method used

A pH/pectinase dual-stimulation responsive nanomaterial was prepared by hybridizing mesoporous silica nanoparticles with organosilicon compounds to form a regular hollow structure, and then modifying the surface with pectin to achieve dual-stimulation responsive drug release.

Benefits of technology

It achieves precise drug release in specific pathological microenvironments, improves the targeting and efficiency of drug delivery, enhances the photostability and biocompatibility of drugs, reduces damage to normal cells and environmental toxicity, and has good controlled release effect and high drug loading rate.

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Abstract

The invention relates to the technical field of nano materials, in particular to a preparation method and application of a pH / pectinase dual stimulation response nano material. MSN-coated PMO is successfully prepared by adopting a hard template method, a carbonate aqueous solution is used for chemical etching to obtain H-PMO with a regular hollow structure, a silane coupling agent APTES is used for performing amination modification on H-PMO, then the H-PMO is used as a carrier to load PRO, and finally Pec is used for coating the H-PMO, so that PPHP is successfully synthesized. The obtained PPHP has pH / pectinase dual stimulation response characteristics, shows excellent drug release rate, light stability and antibacterial activity, shows reliable wettability on leaves, and has remarkable environmental friendliness and biocompatibility; and the whole preparation method is simple and convenient, is high in operability and has a wide application prospect.
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Citation Information

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