Automatic cup arranging and loading device for reaction cups of chemiluminescence immunoassay analyzer and control method

Abstract

The invention discloses an automatic cup arranging and loading device for reaction cups of a chemiluminescence immunoassay analyzer and a control method, and belongs to the technical field of immunoassay equipment automation, and the automatic cup arranging and loading device comprises a funnel-shaped reaction cup stock bin which is positioned at the upper part of the device and is used for storing the reaction cups; the rotating disturbance mechanism is suspended in the stock bin, the rotating axis of the rotating disturbance mechanism is coaxial with a bottom circular truncated cone and a bottom circular hole of the stock bin, and the rotating disturbance mechanism is used for disturbing the reaction cups to fall down orderly; the sorting and loading module is arranged below the stock bin and is used for receiving the falling reaction cups and arranging the reaction cups in the slide way in sequence; the cup pushing and isolating module is arranged at the tail end of the sequencing and loading module and is used for isolating the reaction cup at the tail end of the slide way from other reaction cups; the supporting platform is located on the side portion of the device and used for fixing and limiting all the modules. According to the invention, automatic, efficient and orderly cup arranging and loading of the reaction cups can be realized, the detection efficiency and stability of the chemiluminescence immunoassay instrument are improved, and the device is suitable for high-throughput detection scenes.

Description

Technical Field

[0001] The present invention belongs to the technical field of automation of immunoassay equipment, and in particular relates to an automatic cup-arranging and loading device for reaction cups of a chemiluminescence immunoassay analyzer and a control method thereof. Background Art

[0002] Chemiluminescence immunoassay analyzers are widely used in medical fields such as clinical immunology testing, tumor marker screening, thyroid function assessment, myocardial injury marker determination, and infectious pathogen antibody / antigen detection, providing accurate data support for early diagnosis, treatment monitoring, and epidemiological surveys of diseases. The reaction cups of the chemiluminescence immunoassay analyzer are key consumables for carrying antigen-antibody reactions and chemiluminescence processes. The automatic cup sorting and loading function of the reaction cups is achieved through the coordinated operation of the mechanical structure and the control system to realize the automated processing process of the reaction cups from the stacked storage state to the orderly single cup output. The reaction cups after sorting can be grasped by the gripper to achieve seamless connection with the sample addition, reaction and other processes. The automatic cup sorting and loading of the reaction cups of the chemiluminescence immunoassay analyzer needs to achieve the continuous supply of hundreds to thousands of reaction cups, which is suitable for automated batch use in high-throughput detection scenarios.

[0003] Currently, there are several ways to implement automatic cuvette loading in chemiluminescence immunoassay analyzers: One is a crawler-type cup scooping structure, which consists of a number of cup scooping blocks or picking blocks spaced apart on a conveyor chain or synchronous belt drive structure. The cups are scooped or picked up one by one by the cup scooping blocks or picking blocks, and then sorted and loaded (such as the automatic cup loading device with patent publication number CN108845155A and the automatic cup loading device and sample analyzer with patent publication number CN111033268A). This type of loading device has a complex structure, large size, high cost, and a high failure rate.

[0004] One is a disc-type cup scooping structure, which consists of a number of cup picking fingers or lifting blocks and cup pushing protrusions or stirring blocks arranged at intervals on a rotating disk drive structure. The cup picking fingers or lifting blocks pick up the reaction cups one by one, and the cup pushing protrusions or stirring blocks can improve the picking efficiency (such as the automatic material cup loading device based on a chemiluminescence immunoassay with patent publication number CN208026755U and the automatic continuous loading device for reaction cups with patent publication number CN114414825A). The loading device of this type has a complex structure and a large volume, and the rotating disk is upright. The cup picking or cup pushing parts arranged on it interact with the disorderly stacked reaction cups in the hopper during the downward process, which can easily squeeze the reaction cups and cause jamming and other faults.

[0005] Another type is a push-rod cup scooping structure, which uses a push plate that slides up and down in the accommodating chamber to push out the reaction cups one by one, and then sort and load them (such as the loading device with patent publication number CN112811206A). This type of loading device has low cup scooping efficiency, especially when there are a small number of reaction cups in the hopper. If there are a large number of reaction cups in the hopper, multiple reaction cups may be ejected simultaneously, causing the reaction cups to get stuck in the channel.

[0006] Therefore, there is a need for a device that has a compact structure, low cost, low failure rate, and can efficiently and stably realize continuous automatic cuvette sorting and loading. Summary of the Invention

[0007] In view of the above, the purpose of the present invention is to provide an automatic cup sorting and loading device and control method for chemiluminescence immunoassay cuvettes. By setting up a funnel-shaped cuvette hopper, the reaction cups are centrally stored, and a rotary disturbance mechanism is used to make the reaction cups fall in an orderly manner. With the help of a sorting and loading module, the reaction cups are arranged in sequence, and then a cup pushing isolation module is used to accurately isolate individual reaction cups, so as to realize automatic, efficient and orderly cup sorting and loading of reaction cups, improve the detection efficiency and stability of the chemiluminescence immunoassay, and be suitable for high-throughput detection scenarios.

[0008] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: An embodiment of the present invention provides an automatic cup sorting and loading device for reaction cups of a chemiluminescence immunoassay analyzer, comprising: a funnel-shaped reaction cup hopper, a rotary disturbance mechanism, a sorting and loading module, a cup pushing and isolating module, and a support platform; The funnel-shaped reaction cup silo is located at the upper part of the device and is used to store reaction cups; The rotary disturbance mechanism is suspended inside the funnel-shaped reaction cup material bin, and its rotation axis is coaxial with the bottom frustum and the bottom circular hole of the funnel-shaped reaction cup material bin, and is used to disturb the reaction cup to make it fall in an orderly manner; The sorting and loading module is arranged below the funnel-shaped cuvette hopper and is used to receive cuvettes dropped from the funnel-shaped cuvette hopper and arrange them in order in the slideway; The push cup isolation module is provided at the end of the sorting and loading module, and is used to isolate the reaction cup at the end of the slideway in the sorting and loading module from the rest of the reaction cups; The support platform is located on the side of the device and is used to fix and limit the funnel-shaped reaction cup material bin, the rotation disturbance mechanism, the sorting and loading module and the push cup isolation module.

[0009] Preferably, the funnel-shaped reaction cup material bin includes a top cover, a cup injection port, a storage bin, a bottom frustum hole, a bottom circular hole and a bottom slot; The top cover includes a fixed part and an opening and closing part. The fixed part is provided with an opening for avoiding the rotation disturbance mechanism, and the opening and closing part is used to close or open the cup-dropping opening. The storage bin is located below the top cover and the cup opening and is used to store a certain number of reaction cups; The bottom frustum hole is located below the storage bin, and the inclination angle of the frustum is adapted to the shape of the reaction cup; The bottom circular hole is located below the bottom frustum hole and includes three sections: upper, middle, and lower. The upper circular hole is connected to the bottom frustum hole and transitions through an arc surface. The middle and lower circular holes are both straight holes with fixed diameters that match the size and shape of the reaction cup. The middle and lower circular holes have a smooth transition. The bottom card slot is used for being fixedly connected with the sorting and loading module.

[0010] Preferably, the inclination angle of the frustum of the bottom frustum hole is 40 to 50 degrees, preferably 45 degrees.

[0011] Preferably, the diameter of the middle section of the bottom circular hole is 2 to 3 times the outer diameter of the reaction cup body, the sum of the heights of the upper and middle circular holes should be less than the height of the reaction cup body, and the diameter of the lower circular hole is 1 to 1.5 times the diameter of the reaction cup flange.

[0012] Preferably, the rotation disturbance mechanism comprises a rotation disturbance rod, a drive motor and a motor mounting seat; The upper end of the rotating disturbance rod is connected to the drive motor shaft, and the lower end is bifurcated into a rod body with an included angle, and the end of the rod body is bent inward; The driving motor is used to drive the rotating disturbance rod to rotate around the axis and control the rotation angle, rotation speed, rotation acceleration and rotation direction of the rotating disturbance rod; The motor mounting seat is fixedly connected to the supporting platform and is used to fix the driving motor and ensure that the rotation disturbance mechanism is suspended in the reaction cup material bin.

[0013] Preferably, the lower end of the rotating disturbance rod is bifurcated into two rod bodies, and the two rod bodies form an angle of 45 to 55 degrees, preferably an angle of 50 degrees.

[0014] Preferably, the sorting and loading module includes a slide plate, a connecting block and a baffle; The slide plate and the connecting block are used to construct a slide. The slide has an inclination angle of 15 to 20 degrees with the horizontal direction, preferably 15 degrees. The slide width is greater than the diameter of the reaction cup body and less than the diameter of the reaction cup flange. The slide depth is greater than the height of the reaction cup body. The end of the slide has a horizontal section with a length less than the diameter of the reaction cup. The baffle is arranged on the outside of the slideway to prevent the reaction cup from falling out.

[0015] Preferably, the push cup isolation module includes an electric push rod, a push rod and a mounting seat; The electric push rod moves in a direction perpendicular to the slideway and is used to drive the lever to extend or retract; The lever is fixed to the end of the electric push rod, and its front end forms an angle of 25 to 35 degrees with the direction of movement of the push rod, preferably an angle of 30 degrees, for pushing the reaction cup upward when extended; The mounting seat is fixed to the supporting platform, is used for fixedly connecting the electric push rod, and plays a guiding role for the shifting rod.

[0016] Preferably, the funnel-shaped reaction cup hopper is provided with at least one photoelectric detection sensor located at different height positions of the funnel-shaped reaction cup hopper for monitoring the storage amount of the reaction cup; the sorting and loading module is also provided with a photoelectric detection sensor located on the side of the sorting and loading module for detecting the number of reaction cups in the slide.

[0017] To achieve the above-mentioned object of the invention, an embodiment of the present invention further provides a method for controlling the automatic cup arrangement and loading device for the reaction cup of the chemiluminescence immunoassay analyzer, comprising the following steps: S1, continuously stirring the cuvettes stored in the funnel-shaped cuvette hopper through a rotating disturbance mechanism to promote their orderly falling; S2, receiving the cuvettes through the sorting loading module and arranging them in sequence in the slide; S3, isolating the cuvette at the end of the slide in the sorting and loading module from the other cuvettes through the cuvette pusher isolation module, so that the gripper of the chemiluminescence immunoassay analyzer can grab the cuvette at the end; S4, monitors the number of reaction cups in the funnel-shaped reaction cup hopper and the slide through a photoelectric detection sensor, and feedback controls the operation of the rotation disturbance mechanism and the push cup isolation module.

[0018] Compared with the prior art, the present invention has the following beneficial effects: (1) The device has a simple structure: the funnel-shaped reaction cup hopper is combined with the inverted Y-shaped rotating disturbance mechanism to realize the automatic falling of a single reaction cup. When the reaction cup falls into the slide, it can automatically adjust its posture and arrange in sequence. There is no complicated structure such as cup scooping, cup turning, and conveying.

[0019] (2) The device is easy to operate: the reaction cup can be automatically dropped by controlling the rotation of the rotary disturbance mechanism to drive the motor. The falling reaction cup automatically adjusts its posture and slides down by its own gravity, so that the reaction cups in the slide are arranged in order. There is no need to detect and control the posture of the reaction cup when it falls.

[0020] (3) High cup sorting efficiency: All the cuvettes that automatically fall from the cuvette hopper enter the slide for sorting and loading, without the need to screen the cuvettes according to their falling posture, thus improving the efficiency of cuvette sorting. In addition, the frequency of cuvettes automatically falling from the hopper is not affected by the number of cups in the cuvette hopper, and the efficiency of cuvette sorting does not decrease as the number of cuvettes in the hopper decreases. At the same time, the rotary disturbance mechanism can actively stir the cuvettes in the cuvette hopper to avoid affecting the efficiency of cuvette sorting due to the accumulation of cuvettes.

[0021] (4) Fewer cup handling failures: The rotating disturbance rod of the rotating disturbance mechanism is suspended in the reaction cup hopper and rotates horizontally, pushing the reaction cup only in the horizontal direction, avoiding the occurrence of failures such as the movement mechanism being stuck or the reaction cup being squeezed or bounced due to the vertical contact of the movement mechanism such as the cup scooping mechanism with the reaction cup. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0023] Figure 1 2 is a schematic structural diagram of an automatic cup arrangement and loading device for a chemiluminescence immunoassay analyzer provided in an embodiment of the present invention; Figure 2 2 is a side view of an automatic cuvette arrangement and loading device for a chemiluminescent immunoassay analyzer provided in an embodiment of the present invention; Figure 3 is a cross-sectional view of a funnel-shaped cuvette hopper provided by an embodiment of the present invention; Figure 4 1 is a schematic structural diagram of a rotation disturbance mechanism provided by an embodiment of the present invention; Figure 5 is a structural diagram of a sorting and loading module provided by an embodiment of the present invention; Figure 6 2. It is a top view of the automatic cup arrangement and loading device for the chemiluminescence immunoassay analyzer provided in an embodiment of the present invention; Figure 7 The figure is a flow chart of a control method of an automatic cup arrangement and loading device for a chemiluminescence immunoassay analyzer provided in an embodiment of the present invention.

[0024] The specific symbols in the drawings and embodiments are as follows: 1. Funnel-shaped reaction cup hopper; 11. Top cover; 12. Cup injection port; 13. Storage bin; 14. Bottom cone hole; 15. Bottom circular hole; 151. Upper circular hole; 152. Middle circular hole; 153. Lower circular hole; 16. Bottom slot; 17. Photoelectric detection sensor for funnel-shaped reaction cup hopper; 2. Rotary disturbance mechanism; 21. Rotary disturbance rod; 22. Drive motor; 23. Motor mounting base; 3. Sorting and loading module; 31. Slide plate I; 32. Slide plate II; 33. Connecting block I; 34. Connecting block II; 35. Baffle I; 36. Baffle II; 37. Baffle III; 38. Photoelectric detection sensor for sorting and loading module; 4. Cup pusher isolation module; 41. Electric push rod; 42. Push rod; 43. Mounting base; 5. Support platform DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and do not limit the scope of protection of the present invention.

[0026] The inventive concept of the present invention is: to address the problems existing in the cup sorting and loading process of the chemiluminescence immunoassay reaction cup, such as the complex cup sorting implementation method, the low efficiency of the cup scooping mechanism, and the easy occurrence of cup jamming failures, the embodiment of the present invention provides an automatic cup sorting and loading device and control method for the reaction cups of a chemiluminescence immunoassay. Through the coordinated cooperation of the funnel-shaped reaction cup hopper for storage, the orderly falling controlled by the rotary disturbance mechanism, the automatic cup arrangement by the sorting and loading module, and the precise isolation by the cup pushing and isolating module, the automatic cup sorting and loading function of the reaction cups can be realized efficiently and stably. The device has a simple structure and a simple control method, and can meet the needs of high-throughput detection.

[0027] like Figure 1 and Figure 2As shown, an embodiment provides an automatic cuvette sorting and loading device for a chemiluminescent immunoassay analyzer, comprising a funnel-shaped cuvette hopper 1, a rotary perturbation mechanism 2, a sorting and loading module 3, a cup pusher isolation module 4, and a support platform 5. The funnel-shaped cuvette hopper 1 is positioned above the sorting and loading module 3, with its bottom fixedly connected to one end of the sorting and loading module 3. The rotary perturbation mechanism 2 is suspended within the funnel-shaped cuvette hopper 1, with its rotation axis coaxial with the bottom conical hole 14 and bottom circular hole 15 of the funnel-shaped cuvette hopper 1. The cup pusher isolation module 4 is fixedly connected to the other end of the sorting and loading module 3. The funnel-shaped cuvette hopper 1 and the rotary perturbation mechanism 2 are fixed and restrained at the top of the device by the support platform 5. The sorting and loading module 3 and the cup pusher isolation module 4 are also fixed and restrained at the bottom of the device by the support platform 5. The funnel-shaped cuvette hopper 1 is used to store cuvettes and cooperates with the rotary perturbation mechanism 2 to automatically drop individual cuvettes. The sorting and loading module 3 receives cuvettes dropped from the funnel-shaped cuvette hopper 1 and automatically adjusts the position of the dropped cuvettes, allowing them to slide down under their own gravity, thereby arranging the cuvettes in order within the slide. The cup pusher isolation module 4 separates the cuvette at the end of the slide from the other cuvettes by a distance, allowing the gripper of the chemiluminescent immunoassay analyzer to grasp the cuvette at the end without hindrance. The support platform 5 secures the funnel-shaped cuvette hopper 1, the rotary perturbation mechanism 2, the sorting and loading module 3, and the cup pusher isolation module 4, defining their relative positions.

[0028] Specifically, if Figure 3As shown, the funnel-shaped cuvette hopper 1 comprises a top cover 11, a cup delivery opening 12, a storage compartment 13, a bottom conical hole 14, a bottom circular hole 15, and a bottom retaining slot 16. The top cover 11 is located at the top of the funnel-shaped cuvette hopper 1 and is used to close the upper opening of the funnel-shaped cuvette hopper 1 to prevent cuvettes from overflowing the hopper. The top cover 11 is divided into a fixed portion and an opening and closing portion. The fixed portion is fixedly connected to the funnel-shaped cuvette hopper 1 and has an opening that avoids the rotational disturbance mechanism 2. The opening and closing portion is movable and is used to close or open the cup delivery opening 12 above the funnel-shaped cuvette hopper 1. Below the top cover 11 and cup delivery opening 12 of the funnel-shaped cuvette hopper 1 is a storage compartment 13 for storing a certain number of cuvettes. The size and shape of the storage compartment 13 can be determined based on the number of cuvettes required for the chemiluminescence immunoassay and the spatial layout of the instrument. Below the storage bin 13 is a bottom truncated cone hole 14 , the inclination angle of which is fixed and adapted to the size and shape of the reaction cup, preferably 45 degrees; the diameter of the bottom surface is fixed and adapted to the size and shape of the reaction cup. Below the bottom conical hole 14 is a bottom circular hole 15, which is divided into three sections: upper, middle, and lower. The upper circular hole 151 connects to the bottom conical hole 14 and transitions to it via an arcuate surface. The middle circular hole 152 is a straight hole with a fixed diameter that matches the size and shape of the cuvette, preferably 2 to 3 times the outer diameter of the cuvette body. The combined height of the upper and middle circular holes 151, 152 should be less than the height of the cuvette body, ensuring that a portion of the cuvette body that has not fallen is located within the bottom conical hole 14, allowing the rotating disturbance mechanism 2 to disturb and change its position. The lower circular hole 153 is a straight hole with a fixed diameter that matches the size and shape of the cuvette, preferably 1 to 1.5 times the diameter of the cuvette flange. The transition between the middle and lower circular holes 152, 153 should be smooth. The bottom latch 16 cooperates with the sorting and loading module 3 to provide a fixed connection and a secure clamping mechanism. The distance between the bottom of the funnel-shaped cuvette hopper 1 and the slideway of the sorting and loading module 3 should be no less than the height of the cuvette body. The bottom of the funnel-shaped cuvette hopper 1 is in close proximity to the connecting block 1 33 of the sorting and loading module 3 to facilitate automatic posture adjustment of the falling cuvettes. The funnel-shaped cuvette hopper 1 is provided with a connection portion for fixed connection to the support platform 5. The funnel-shaped cuvette hopper 1 is equipped with a photoelectric detection sensor 17 for monitoring the cuvette storage level in the cuvette hopper. One or more photoelectric detection sensors 17 can be provided, each positioned at different heights.

[0029] Specifically, if Figure 4As shown, the rotary disturbance mechanism 2 consists of a rotary disturbance rod 21, a drive motor 22, and a motor mounting base 23. The rotary disturbance rod 21 is used to agitate the reaction cups in the funnel-shaped reaction cup hopper 1, causing the reaction cups near the bottom conical hole 14 of the funnel-shaped reaction cup hopper 1 to continuously adjust and change their posture, thereby increasing the probability of the reaction cups falling from the bottom circular hole 15. The length of the rotary disturbance rod 21 is determined according to the height of the funnel-shaped reaction cup hopper 1. The upper end of the rotary disturbance rod 21 is fixedly connected to the drive motor shaft, and the rotation axis of the rotary disturbance rod 21 is coaxial with the drive motor shaft. The lower end of the rotary disturbance rod 21 is separated into two rods, with a certain angle between the two rods, preferably 50 degrees. The ends of the two rods are bent inward to form a certain arc. The bent portions of the ends of the two rods are close to the wall surface of the bottom conical hole 14 of the funnel-shaped reaction cup hopper 1 and maintain a certain gap. The rotary disturbance rod 21 has a certain rigidity and should not deform during the stirring of the reaction cups. The shape of the rotating disturbance rod 21 should be smooth and without sharp edges to avoid scratching the reaction cup during stirring. The material of the rotating disturbance rod 21 is preferably wear-resistant plastic. The drive motor 22 is used to drive the rotating disturbance rod 21 to rotate around the axis, and can control the rotation angle, rotation speed, rotation acceleration and rotation direction of the rotating disturbance rod 21 when the funnel-shaped reaction cup silo 1 is full or empty. A stepping motor is preferably used. The motor mounting seat 23 is used to fix the drive motor 22 and ensure that the rotating disturbance mechanism 2 is suspended in the funnel-shaped reaction cup silo 1. The rotation axis of the rotating disturbance rod 21 is coaxial with the bottom conical hole 14 and the bottom circular hole 15 of the funnel-shaped reaction cup silo 1. The motor mounting seat 23 is fixedly connected to the support platform 5.

[0030] Specifically, if Figure 5 As shown, the sorting and loading module 3 consists of a slide plate, a connecting block, a baffle, and a photoelectric detection sensor 38. The slide plate and connecting block form a slide. Slide plate I 31 and slide plate II 32 are fixedly connected by connecting blocks I 33 and II 34, forming a slide with a certain width. The slide width should be slightly larger than the diameter of the cuvette body and smaller than the diameter of the cuvette flange. The slide depth is greater than the height of the cuvette body. The slide has a certain inclination angle, preferably 15 degrees from the horizontal, to ensure that the cuvette can slide smoothly under its own gravity. The end of the slide has a small horizontal section, the length of which should be less than the diameter of the cuvette. The contact area between the slide and the cuvette is smooth to reduce frictional resistance. The baffle is used to prevent the cuvette from falling off the slide during the sliding process. Baffles I 35 and II 36 are fixedly connected to the outside of slide plates I 31 and II 32, and baffle III 37 is fixedly connected to the outside of connecting block I 33. Baffle I 35 and baffle II 36 are provided with photoelectric detection sensors 38 for monitoring the number of reaction cups in the slide. The photoelectric detection sensors 38 can be one or more and be set at different heights.

[0031] Specifically, if Figure 6As shown, the cup pusher isolation module 4 consists of an electric push rod 41, a lever 42, and a mounting base 43. The electric push rod 41 is used to extend or retract the lever 42 a certain distance and is preferably a self-retaining electromagnet. The direction of movement of the electric push rod 41 is perpendicular to the direction of the slide. The lever 42 is used to push all reaction cups in the slide, except for the one at the end, upward, isolating the reaction cup at the end of the slide from the other reaction cups by a certain distance. The lever 42 is fixedly connected to the end of the electric push rod 41. The straight section at the front end of the lever 42 forms a certain angle with the direction of movement of the electric push rod 41, preferably 30 degrees. This angle allows the lever 42 to move perpendicularly to the slide while simultaneously pushing the reaction cup upward along the slide. The greater the distance the lever 42 moves perpendicularly to the slide, the greater the distance the reaction cup moves upward along the slide. The bottom of the lever 42 slides relative to the mounting base 43, providing a guide and preventing the lever 42 from tipping over. The electric push rod 41 is fixedly connected to the mounting base 43. The mounting base 43 is fixedly connected to the support platform 5 and defines the relative position relationship between the shifting rod 42, the slideway and the reaction cup.

[0032] Based on the same inventive concept, Figure 7 As shown, an embodiment of the present invention further provides a method for controlling an automatic cup arrangement and loading device for a chemiluminescence immunoassay cuvette, comprising the following steps: S1, continuously stirring the cuvettes stored in the funnel-shaped cuvette silo 1 by rotating the disturbance mechanism 2 to promote their orderly falling.

[0033] S1.1, open the top cover 11 of the funnel-shaped reaction cup material bin 1, add a certain number of reaction cups from the cup injection port 12, and close the top cover 11.

[0034] S1.2, control the driving motor 22 of the rotary disturbance mechanism 2 to rotate clockwise for a certain angle at a certain acceleration and speed, and then rotate counterclockwise for a certain angle at a certain acceleration and speed, and repeat this cycle. During this process, the reaction cup automatically falls from the circular hole 15 at the bottom of the funnel-shaped reaction cup hopper 1.

[0035] S2, the sorting loading module 3 receives the cuvettes and arranges them in sequence in the slide.

[0036] S2.1, when the falling cuvette contacts the slide of the sorting and loading module 3, it automatically adjusts its posture and slides down by its own gravity, and the cuvettes in the slide are arranged in order.

[0037] S2.2, when the photoelectric detection sensor 38 of the sorting and loading module 3 detects that the number of cuvettes in the slideway has reached a certain number, the driving motor 22 of the rotation disturbance mechanism 2 is controlled to stop rotating.

[0038] S3, the cuvette at the end of the slide in the sorting and loading module 3 is isolated from the other cuvettes by the cuvette pushing and isolating module 4, so as to facilitate the gripper of the chemiluminescence immunoassay instrument to grasp the cuvette at the end.

[0039] S3.1, control the electric push rod 41 of the cup pushing and isolating module 4 to extend a certain distance, and the lever 42 pushes the other reaction cups in the slide except the reaction cup at the end upward along the slide direction, and the clamp of the chemiluminescence immunoassay analyzer clamps the reaction cup at the end.

[0040] S3.2, control the electric push rod 41 of the cup pusher isolation module 4 to retract a certain distance, and the reaction cup in the slide slides downward along the slide direction.

[0041] S3.3. Repeat steps S3.1 and S3.2 according to the needs of using the reaction cup of the chemiluminescence immunoassay analyzer.

[0042] S4, monitoring the number of cuvettes in the funnel-shaped cuvette hopper 1 and the slideway through a photoelectric detection sensor, and feedback-controlling the operation of the rotation disturbance mechanism 2 and the cup pusher isolation module 4.

[0043] S4.1, when the photoelectric detection sensor 38 of the sorting and loading module detects that the number of cuvettes in the slide is insufficient, repeat steps S1.2 and S2.2.

[0044] S4.2, when the funnel-shaped cuvette material bin photoelectric detection sensor 17 detects that the number of cuvettes in the funnel-shaped cuvette material bin 1 is insufficient, step S1.1 is repeated.

[0045] The specific implementation methods described above provide a detailed description of the technical solutions and beneficial effects of the present invention. It should be understood that the above is only the most preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, supplements and equivalent substitutions made within the scope of the principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An automatic cup arrangement and loading device for a chemiluminescence immunoassay analyzer reaction cup, characterized in that: include: Funnel-shaped reaction cup silo, rotating disturbance mechanism, sorting loading module, push cup isolation module and support platform; The funnel-shaped reaction cup silo is located at the upper part of the device and is used to store reaction cups; The rotary disturbance mechanism is suspended inside the funnel-shaped reaction cup material bin, and its rotation axis is coaxial with the bottom frustum and the bottom circular hole of the funnel-shaped reaction cup material bin, and is used to disturb the reaction cup to make it fall in an orderly manner; The sorting and loading module is arranged below the funnel-shaped cuvette hopper and is used to receive cuvettes dropped from the funnel-shaped cuvette hopper and arrange them in order in the slideway; The push cup isolation module is provided at the end of the sorting and loading module, and is used to isolate the reaction cup at the end of the slideway in the sorting and loading module from the rest of the reaction cups; The support platform is located on the side of the device and is used to fix and limit the funnel-shaped reaction cup material bin, the rotation disturbance mechanism, the sorting and loading module and the push cup isolation module.

2. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 1, characterized in that: The funnel-shaped reaction cup material bin includes a top cover, a cup injection port, a storage bin, a bottom frustum hole, a bottom circular hole and a bottom card slot; The top cover includes a fixed part and an opening and closing part. The fixed part is provided with an opening for avoiding the rotation disturbance mechanism, and the opening and closing part is used to close or open the cup-dropping opening. The storage bin is located below the top cover and the cup opening and is used to store a certain number of reaction cups; The bottom frustum hole is located below the storage bin, and the inclination angle of the frustum is adapted to the shape of the reaction cup; The bottom circular hole is located below the bottom frustum hole and includes three sections: upper, middle, and lower. The upper circular hole is connected to the bottom frustum hole and transitions through an arc surface. The middle and lower circular holes are both straight holes with fixed diameters that match the size and shape of the reaction cup. The middle and lower circular holes have a smooth transition. The bottom card slot is used for being fixedly connected with the sorting and loading module.

3. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 2, characterized in that: The frustum inclination angle of the bottom frustum hole is 40 to 50 degrees.

4. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 2, characterized in that: The diameter of the middle section of the bottom circular hole is 2 to 3 times the outer diameter of the reaction cup body, the sum of the heights of the upper and middle circular holes should be less than the height of the reaction cup body, and the diameter of the lower circular hole is 1 to 1.5 times the diameter of the reaction cup flange.

5. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 1, characterized in that: The rotation disturbance mechanism includes a rotation disturbance rod, a drive motor and a motor mounting seat; The upper end of the rotating disturbance rod is connected to the drive motor shaft, and the lower end is bifurcated into a rod body with an included angle, and the end of the rod body is bent inward; The driving motor is used to drive the rotating disturbance rod to rotate around the axis and control the rotation angle, rotation speed, rotation acceleration and rotation direction of the rotating disturbance rod; The motor mounting seat is fixedly connected to the supporting platform and is used to fix the driving motor and ensure that the rotation disturbance mechanism is suspended in the reaction cup material bin.

6. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 5, characterized in that: The lower end of the rotating disturbance rod is bifurcated into two rod bodies, and the two rod bodies form an angle of 45 to 55 degrees.

7. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 1, characterized in that: The sorting and loading module includes a slide plate, a connecting block and a baffle; The slide plate and the connecting block are used to construct a slide, the slide has an inclination angle of 15 to 20 degrees with the horizontal direction, the slide width is greater than the diameter of the reaction cup body and less than the diameter of the reaction cup flange, the slide depth is greater than the height of the reaction cup body, and the end of the slide has a horizontal section with a length less than the diameter of the reaction cup; The baffle is arranged on the outside of the slideway to prevent the reaction cup from falling out.

8. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 1, characterized in that: The push cup isolation module includes an electric push rod, a push rod and a mounting seat; The electric push rod moves in a direction perpendicular to the slideway and is used to drive the lever to extend or retract; The lever is fixed to the end of the electric push rod, and its front end forms an angle of 25 to 35 degrees with the direction of movement of the push rod, and is used to push the reaction cup upward when extended; The mounting seat is fixed to the supporting platform, is used for fixedly connecting the electric push rod, and plays a guiding role for the shifting rod.

9. The automatic cup arrangement and loading device for chemiluminescence immunoassay analyzer reaction cups according to claim 1, characterized in that: The funnel-shaped reaction cup hopper is provided with at least one photoelectric detection sensor located at different height positions of the funnel-shaped reaction cup hopper for monitoring the storage capacity of the reaction cup; the sorting and loading module is also provided with a photoelectric detection sensor located on the side of the sorting and loading module for detecting the number of reaction cups in the slide.

10. A method for controlling the automatic cup arrangement and loading device for a chemiluminescence immunoassay analyzer according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1, continuously stirring the cuvettes stored in the funnel-shaped cuvette hopper through a rotating disturbance mechanism to promote their orderly falling; S2, receiving the cuvettes through the sorting loading module and arranging them in sequence in the slide; S3, isolating the cuvette at the end of the slide in the sorting and loading module from the other cuvettes through the cuvette pusher isolation module, so that the gripper of the chemiluminescence immunoassay analyzer can grab the cuvette at the end; S4, monitors the number of reaction cups in the funnel-shaped reaction cup hopper and the slide through a photoelectric detection sensor, and feedback controls the operation of the rotation disturbance mechanism and the push cup isolation module.

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