Space orientation obstacle model preparation device and method

Abstract

The invention relates to the technical field of animal experiment equipment, and discloses a spatial orientation obstacle model preparation device and method.The spatial orientation obstacle model preparation device comprises a rotating platform which is provided with an animal fixing device and an electrical stimulation device and can achieve automatic lifting, horizontal rotation and inclination at any angle in the front / back / left / right direction; the space orientation training and detecting unit is located around the rotating platform; the sealing cover covers the rotating platform and the space orientation training and detecting unit; the climate environment simulation system comprises a smoke regulation and control device and a light regulation and control device, and the smoke regulation and control device controls smoke generation through a water supply pipeline and an electromagnetic valve. According to the invention, the experimental animal is fixed on the rotating platform, and different types of spatial orientation obstacle models are prepared by changing the operation parameters and operation scenes of the spatial orientation obstacle simulation generation device.

Description

Technical Field

[0001] This invention relates to the field of animal experimental equipment technology, specifically to a device and method for preparing a spatial orientation obstacle model. Background Art

[0002] Flight spatial orientation is a cognitive process by which pilots identify and judge ground and air targets, flight status, and the spatial relationship between themselves and the flight environment. Spatial orientation is the most core element of flight capability structure. Spatial orientation in flight is based on information from multiple sensory channels, including vision, the vestibular system, and proprioceptors, with different types of information processed at different levels. Errors in the central nervous system's processing and integration of visual spatial information during flight lead to erroneous information dominating spatial perception, which is the fundamental neural mechanism behind spatial orientation disorders. According to reports from both domestic and international sources, almost 100% of pilots experience spatial orientation disorders at some point in their careers. This phenomenon is particularly prevalent at night, in complex weather conditions (thunderstorms, snow, fog, etc.), and at sea.

[0003] To date, severe spatial disorientation remains the leading human factor in helicopter accidents. While there is considerable research on the clinical manifestations of spatial disorientation, research on its underlying mechanisms, particularly its neural mechanisms and intervention targets, is limited. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention proposes a device and method for preparing a spatial orientation disorder model, which solves the problem of a lack of animal experimental models in the research on the occurrence mechanism and prevention of spatial orientation disorder.

[0005] Firstly, a spatial orientation obstacle model preparation device is provided, comprising: The rotating platform is equipped with animal restraint devices and electrical stimulation devices, and can automatically lift, rotate horizontally, and tilt at any angle in four directions: forward, backward, left, and right. The spatial orientation training and testing unit is located around the rotating platform; A sealed cover is provided to cover the rotating platform and the spatial orientation training and detection unit. The climate environment simulation system includes a smoke control device and a light control device. The smoke control device controls smoke generation through a water supply pipeline and a solenoid valve.

[0006] Furthermore, the rotating platform includes a base and a circular turntable rotatably connected to the base. The animal fixing device is disposed on the circular turntable and fixedly connected to the base. The rotating platform is connected to a power device, which drives the turntable to rotate horizontally and tilt in multiple directions.

[0007] Furthermore, the smoke control device includes a smoke sensor, which is connected to the control system and provides feedback to regulate the opening and closing of the solenoid valve.

[0008] Furthermore, the light control device is fixed to the inner wall of the sealing cover and is distributed in multiple points around the rotating platform.

[0009] Furthermore, the spatial orientation training and testing unit includes four cavities arranged around the rotating platform. The four cavities and the sealing cover together form a sealed space, and each cavity is equipped with a light, sound and food reward device, and different image symbols are displayed on each cavity.

[0010] Secondly, a method for preparing a spatial orientation obstacle model is provided, based on a spatial orientation obstacle model preparation device as described in any of the preceding claims, comprising: Spatial orientation training was conducted on laboratory animals, using light / sound stimuli to guide them to find a food reward device containing sugar pills, for n days; The baseline time for the test animal to reach the reward area is on day n+1. Animals are fixed to a rotating platform, and spatial disorientation is induced by adjusting the platform's rotation speed, turning frequency, tilt angle / frequency of the animal's restraints, and lifting parameters, combined with smoke and light to simulate the environment. The model was established based on the criteria for determining the type of impairment, wherein the types include visual, vestibular, and visual-vestibular spatial orientation impairment models.

[0011] Furthermore, during the preparation of the visual spatial orientation obstacle model; The animal's torso is fixed vertically, while the rotating platform rotates horizontally alternately clockwise and counterclockwise, accompanied by rising and falling. The disappearance of the blink reflex due to corneal stimulation is considered a sign of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and its need for light assistance.

[0012] Furthermore, when preparing the vestibular spatial orientation disorder model: The animal's torso is fixed vertically, and the animal restraint device tilts forward / backward / left / right and rises and falls accordingly. A successful mold-making process is indicated by the head swinging in the opposite direction to the tilting direction of the rotating platform. After returning to the correct position, electrical stimulation is applied, and the severity of the disorder is determined based on the time it takes for the animal to reach the reward area and its need for auditory assistance.

[0013] Furthermore, when preparing the visual-vestibular spatial orientation disorder model: The animal's torso is vertically fixed, while the rotating platform rotates horizontally in sync with the animal's restraint device tilting in multiple directions and rising and falling simultaneously. The disappearance of the blink reflex and the head movement in the opposite direction to the tilt direction are signs of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and the degree of need for combined light and sound assistance.

[0014] Furthermore, the smoke control device simulates a dense fog environment, and the light control device simulates morning / noon / nighttime lighting conditions to construct a spatial orientation obstacle model for special operational scenarios.

[0015] The invention employing the above technical solution has the following advantages: 1. This invention employs a circular rotating platform that can rotate counterclockwise or clockwise, or alternately. The animal restraint device on the rotating platform can tilt at any angle in four directions: forward, backward, left, and right, and the frequency of position changes is adjustable. By changing the movement state and body position of the model animal, different types of spatial orientation obstacle models are established.

[0016] 2. This invention, by altering the animal's movement state and body position, and simultaneously using smoke and light control devices to change external environmental conditions such as visibility and time intervals, establishes visual, vestibular, and visual-vestibular spatial orientation disorder models under special operational scenarios, enabling multi-dimensional comparison of spatial orientation disorder models. Attached Figure Description

[0017] To more clearly illustrate the specific embodiments of the present invention, the accompanying drawings used in the specific embodiments will be briefly described below. In all the drawings, the elements or parts are not necessarily drawn to scale.

[0018] Figure 1 The structure of a spatial orientation obstacle model preparation device according to the present invention. Figure 1 ; Figure 2 The structure of a spatial orientation obstacle model preparation device according to the present invention. Figure 2 ; Figure 3 This is a flowchart of a method for preparing a spatial orientation obstacle model according to the present invention; Figure label: 1. Rotating platform; 2. Animal restraint device; 3. Electrical stimulation device. Spatial orientation training and testing unit 41, lighting device 42, sound device 43, food reward device 44. 5. Sealing cap; 51. Ventilation port. Detailed Implementation

[0019] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0020] The terms "first," "second," etc., in the specification, claims, and accompanying drawings of this application are used to distinguish different objects, not to describe a specific order. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products, or apparatuses.

[0021] References to "embodiments" in this application mean that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described in this application may be combined with other embodiments.

[0022] like Figures 1-3 As shown, a spatial orientation obstacle model preparation device of the present invention includes: The rotating platform 1 is equipped with an animal restraint device 2 and an electric stimulation device 3, which can automatically lift, rotate horizontally, and tilt at any angle in four directions: forward, backward, left, and right. Spatial orientation training and testing unit 41 is located around the rotating platform 1; A sealed cover 5 covers the rotating platform 1 and the spatial orientation training and testing unit 41. Multiple ventilation holes 51 are provided on the sealed cover 5. The climate environment simulation system includes a smoke control device (not shown in the figure) and a light control device (a lighting device with continuously adjustable brightness from weak to strong). The smoke control device controls the generation of smoke through water supply pipes and solenoid valves. It also includes: a control system that connects to and controls the rotating platform 1, the spatial orientation training and testing unit 41, the smoke control device, and the light control device.

[0023] In this embodiment, the rotating platform 1 includes a base and a circular turntable rotatably connected to the base. The animal fixing device 2 is disposed on the circular turntable and connected to the base. The rotating platform 1 is connected to a power device, which drives the turntable to rotate horizontally and tilt in multiple directions.

[0024] In this embodiment, the smoke control device includes a smoke sensor; the smoke control device also includes a smoke generator. The smoke sensor is fixed to the inner wall of the sealing cover 5. One end of the water supply pipe is connected to an external water pipe, and the other end extends into the interior of the sealing cover 5 and is finally connected to the smoke generator. The solenoid valve is installed at the inlet of the water supply pipe. The smoke sensor is connected to the control system and provides feedback to regulate the opening and closing of the solenoid valve.

[0025] Specifically, the smoke generated by the smoke generator is released into the sealed space. The smoke sensor is used to monitor the smoke concentration and feed it back to the control system. The control system realizes dynamic adjustment (such as opening the solenoid valve when the concentration is insufficient) to adjust the water flow switch and control the amount of smoke generated.

[0026] In this embodiment, the light control device (not shown in the figure) is fixed to the inner wall of the sealing cover 5 and is distributed in multiple points around the rotating platform 1.

[0027] Specifically, by covering the entire platform with lighting, continuous brightness adjustment from weak to strong is achieved to simulate different climatic environments on the board.

[0028] In this embodiment, the spatial orientation training and detection unit 41 includes four accommodating cavities arranged around the rotating platform 1. The four accommodating cavities and the sealing cover 5 together form a sealed space. Each accommodating cavity is equipped with a lighting device 42, a sound device 43 and a food reward device 44, and different image symbols are displayed on each accommodating cavity.

[0029] Specifically, the four containment chambers are fixedly connected to the base, and the entrances of the four containment chambers all face the rotating platform 1 and are connected to the rotating platform 1, allowing experimental animals to enter and exit freely. The tops of the four containment chambers are tightly sealed with the sealing cap 5, forming a sealed space together. Each containment chamber displays different image symbols on the inner wall of its entrance facing the rotating platform 1, and is equipped with a lighting device 42, a sound device 43, and a food reward device 44.

[0030] Specifically, before model preparation, experimental animals underwent 5 days of spatial orientation training; the animals were fasted the day before training. During training, the experimental animals were placed in the center of the rotating platform 1 for 1 minute to allow them to fully adapt to the environment. Then, the sealing cover was closed, and the rotating platform 1 was electrified, causing the experimental animals to receive an electric shock. Simultaneously, light and sound stimuli were provided in the four compartments of the spatial orientation training and detection unit 41, with only one compartment containing a sugar pill. If the experimental animal found the food reward device 44 containing the sugar pill within 2 minutes, it was allowed to rest for 1 minute before the training was repeated. If the experimental animal did not find the food reward device 44 containing the sugar pill within 2 minutes, it was guided to enter and stay for 1 minute, and the graphic markings on the compartment were observed. Training was conducted 4 times a day for 4 consecutive days. On the 5th day, the time it took for the experimental animals to reach the compartment (reward area) from the rotating platform 1 was recorded, and the average value was taken after three repetitions.

[0031] According to the experimental requirements, the animal is placed on the fixed seat of the rotating platform 1 with its trunk vertically fixed. The rotation speed of the rotating platform 1, the frequency of alternating clockwise and counterclockwise horizontal rotation, and the angle and frequency of tilting of the fixed seat in the four directions of forward, backward, left, and right, as well as the amplitude and speed of platform lifting and lowering are set. When the rat's cornea is stimulated, the blink reflex disappears or the rat's head swings in the opposite direction to the tilting direction of the platform, it indicates that the animal has spatial orientation disorder, the modeling ends, and then the platform stops rotating and descends to its original position.

[0032] In other embodiments, a method for preparing a spatial orientation obstacle model is provided, based on a spatial orientation obstacle model preparation apparatus according to any one of the preceding embodiments, comprising: Step S01: Spatial orientation training is conducted on the experimental animals. The animals are guided to find the food reward device 44 containing sugar pills by light / sound stimulation for 4 days. Step S02: On day 4+1, test the baseline time for the animal to reach the reward area; Step S03: Fix the animal to the rotating platform 1. By adjusting the rotation speed, turning frequency, tilt angle / frequency and lifting parameters of the animal fixing device 2, combined with smoke and light to simulate the environment, spatial orientation disorder is induced. Step S04: Confirm the model establishment based on the obstacle type judgment criteria, whereby the types include visual, vestibular, and visual-vestibular spatial orientation obstacle models.

[0033] In this embodiment, when preparing the visual spatial orientation obstacle model; The animal's torso is fixed vertically, and the rotating platform 1 rotates horizontally alternately clockwise and counterclockwise while rising and falling. The disappearance of the blink reflex due to corneal stimulation is considered a sign of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and its need for light assistance.

[0034] In this embodiment, when preparing the vestibular spatial orientation disorder model: The animal's torso is vertically fixed, and the animal restraint device 2 tilts forward / backward / left / right and rises and falls accordingly. The successful modeling is indicated by the head swinging direction being opposite to the tilting direction of the rotating platform 1. After returning to the correct position, electrical stimulation is applied, and the severity of the disorder is determined based on the time it takes for the animal to reach the reward area and its need for auditory assistance.

[0035] In this embodiment, when preparing the visual-vestibular spatial orientation disorder model: The animal's torso is vertically fixed, and the rotating platform 1 rotates horizontally in sync with the animal fixing device 2 tilting in multiple directions and rising and falling simultaneously. The disappearance of the blink reflex and the head movement in the opposite direction to the tilt direction are signs of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and the degree of need for combined light and sound assistance.

[0036] In this embodiment, a dense fog environment is simulated by a smoke control device, and light conditions at dawn / noon / night are simulated by a light control device, in order to construct a spatial orientation obstacle model for a special operational scenario.

[0037] Specifically, using the aforementioned spatial orientation disorder model preparation device, different types of spatial orientation disorder models can be prepared by changing the rotation speed of the rotating platform 1, the frequency of alternating clockwise and counterclockwise horizontal rotation, and / or the angle and frequency of tilting of the fixed seat in the four directions of forward / backward / left / right, accompanied by platform lifting and lowering. Spatial orientation disorder models include visual spatial orientation disorder models, vestibular spatial orientation disorder models, and visual-vestibular spatial orientation disorder models.

[0038] All three models include three sub-models: mild, moderate, and severe spatial orientation disorder models.

[0039] Platform rotation and elevation parameter variation group: After rotating platform 1 returned to its original position, electricity was applied to provide electrical stimulation to the experimental animals. Afterwards, the animals were released from restraint. If the experimental animals could correctly reach the training reward area within a predetermined time (average time measured on the fifth day), no spatial orientation disorder was observed. Correctly reaching the training reward area within 200% of the predetermined baseline time indicated mild to moderate visual-spatial orientation disorder. Reaching the training reward area more than 200% of the baseline time, and only after receiving simultaneous light stimulation, indicated moderate visual-spatial orientation disorder. Reaching the training reward area more than 200% of the baseline time, and still unable to correctly identify the training reward area after receiving simultaneous light stimulation, indicated severe visual-spatial orientation disorder.

[0040] Groups with varying seat tilt and platform lifting parameters: After rotating platform 1 returned to its original position, electricity was applied to provide electrical stimulation to the experimental animals. Afterward, the animals were released from restraint. If the animals could correctly reach the training reward area within a predetermined time, no spatial orientation disorder was observed. Correctly reaching the training reward area within 200% of the predetermined baseline time indicated mild vestibular spatial orientation disorder. Reaching the training reward area more than 200% of the baseline time, and only correctly identifying the training reward area after simultaneous auditory stimulation, indicated moderate vestibular spatial orientation disorder. Reaching more than 200% of the baseline time, and still unable to correctly identify the training reward area after simultaneous auditory stimulation, indicated severe vestibular spatial orientation disorder.

[0041] Groups with variations in platform rotation, seat tilt, and platform lifting parameters: After platform 1 returned to its original position, electricity was applied to provide electrical stimulation to the experimental animals. Afterward, the animals were released from restraint. If the animals could correctly reach the training reward area within a predetermined time, no spatial orientation disorder was observed. Correctly reaching the training reward area within 200% of the predetermined baseline time indicated mild visual-vestibular spatial orientation disorder. Correctly identifying the training reward area beyond 200% of the baseline time, and only after receiving both light and sound stimulation, indicated moderate visual-vestibular spatial orientation disorder. Correctly identifying the training reward area beyond 200% of the baseline time, and even after receiving both light and sound stimulation, indicated severe visual-vestibular spatial orientation disorder.

[0042] When preparing special work scenarios, natural environmental conditions such as dense fog are simulated inside the sealed cover 5 by using smoke and light control devices. At the same time, time conditions such as early morning, noon, and night are simulated by combining light changes, thereby realizing the establishment of spatial orientation obstacle models under different work scenarios.

[0043] It should be noted that, for the sake of simplicity, the foregoing method embodiments are all described as a series of actions. However, those skilled in the art should understand that this application is not limited to the described order of actions, as some steps may be performed in other orders or simultaneously according to this application. Furthermore, those skilled in the art should also understand that the embodiments described in the specification are preferred embodiments, and the actions and modules involved are not necessarily essential to this application.

[0044] In the above embodiments, the descriptions of each embodiment have different focuses. For parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0045] In the several embodiments provided in this application, it should be understood that the disclosed apparatus can be implemented in other ways. For example, the apparatus embodiments described above are merely illustrative; for instance, the division of units is only a logical functional division, and in actual implementation, there may be other division methods. For example, multiple units or components may be combined or integrated into another system, or some features may be ignored or not executed. Furthermore, the coupling or direct coupling or communication connection shown or discussed may be through some interfaces; the indirect coupling or communication connection between devices or units may be electrical or other forms.

[0046] The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of these units may be selected to achieve the purpose of this embodiment according to actual needs.

[0047] Furthermore, the functional units in the various embodiments of the application can be integrated into one processing unit, or each unit can exist physically separately, or two or more units can be integrated into one unit. The integrated unit can be implemented in hardware or as a software program module.

[0048] If the integrated unit is implemented as a software program module and sold or used as an independent product, it can be stored in a computer-readable storage device (CMD). Based on this understanding, the technical solution of this application, in essence, or the part that contributes to the prior art, or all or part of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a memory and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of this application. The aforementioned memory includes various media capable of storing program code, such as USB flash drives, read-only memory (ROM), random access memory (RAM), portable hard drives, magnetic disks, or optical disks.

[0049] The embodiments of this application have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, based on the ideas of this application, specific implementation methods and applications can be developed.

Claims

1. A device for preparing a spatial orientation obstacle model, characterized in that, include: The rotating platform is equipped with animal restraint devices and electrical stimulation devices, and can automatically lift, rotate horizontally, and tilt at any angle in four directions: forward, backward, left, and right. The spatial orientation training and testing unit is located around the rotating platform; A sealed cover is provided to cover the rotating platform and the spatial orientation training and detection unit. The climate environment simulation system includes a smoke control device and a light control device. The smoke control device controls smoke generation through a water supply pipeline and a solenoid valve.

2. The spatial orientation obstacle model preparation device according to claim 1, characterized in that, The rotating platform includes a base and a circular turntable rotatably connected to the base. The animal fixing device is located on the circular turntable and fixedly connected to the base. The rotating platform is connected to a power device, which drives the turntable to rotate horizontally and tilt in multiple directions.

3. The spatial orientation obstacle model preparation device according to claim 1, characterized in that, The smoke control device includes a smoke sensor, which is connected to the control system and provides feedback to regulate the opening and closing of the solenoid valve.

4. The spatial orientation obstacle model preparation device according to claim 1, characterized in that, The light control device is fixed to the inner wall of the sealed cover and is distributed in multiple points around the rotating platform.

5. The spatial orientation obstacle model preparation device according to claim 1, characterized in that, The spatial orientation training and testing unit includes four cavities arranged around the rotating platform. The four cavities and the sealing cover together form a sealed space. Each cavity is equipped with a light, sound and food reward device, and different image symbols are displayed on each cavity.

6. A method for preparing a spatial orientation obstacle model, characterized in that, A spatial orientation obstacle model preparation device according to any one of claims 1 to 5, comprising: Spatial orientation training was conducted on laboratory animals, using light / sound stimuli to guide them to find a food reward device containing sugar pills, for n days; The baseline time for the test animal to reach the reward area is on day n+1. Animals are fixed to a rotating platform, and spatial disorientation is induced by adjusting the platform's rotation speed, turning frequency, tilt angle / frequency of the animal's restraints, and lifting parameters, combined with smoke and light to simulate the environment. The model was established based on the criteria for determining the type of impairment, wherein the types include visual, vestibular, and visual-vestibular spatial orientation impairment models.

7. The method for preparing a spatial orientation obstacle model according to claim 6, characterized in that, When preparing the visual spatial orientation obstacle model; The animal's torso is fixed vertically, while the rotating platform rotates horizontally alternately clockwise and counterclockwise, accompanied by rising and falling. The disappearance of the blink reflex due to corneal stimulation is considered a sign of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and its need for light assistance.

8. The method for preparing a spatial orientation obstacle model according to claim 6, characterized in that, When preparing the vestibular spatial orientation disorder model: The animal's torso is fixed vertically, and the animal restraint device tilts forward / backward / left / right and rises and falls accordingly. A successful mold-making process is indicated by the head swinging in the opposite direction to the tilting direction of the rotating platform. After returning to the correct position, electrical stimulation is applied, and the severity of the disorder is determined based on the time it takes for the animal to reach the reward area and its need for auditory assistance.

9. The method for preparing a spatial orientation obstacle model according to claim 6, characterized in that, When preparing the visual-vestibular spatial orientation disorder model: The animal's torso is vertically fixed, while the rotating platform rotates horizontally in sync with the animal's restraint device tilting in multiple directions and rising and falling simultaneously. The disappearance of the blink reflex and the head movement in the opposite direction to the tilt direction are signs of successful modeling. After returning to their original position, electrical stimulation was applied, and the severity of the disorder was determined based on the time it took for the animal to reach the reward area and the degree of need for combined light and sound assistance.

10. A method for preparing a spatial orientation obstacle model according to claim 6, characterized in that, The smoke control device simulates a dense fog environment, and the light control device simulates morning / noon / nighttime lighting conditions to construct a spatial orientation obstacle model for special operational scenarios.

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