Traditional Chinese medicine composition for treating infantile pneumonia and preparation method and application thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating infantile pneumonia and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-15 parts of rheum officinale, 10-30 parts of compound of glauber-salt and liquorice and 10-30 parts of garlic. The rhubarb has the effects of purgation and removing food retention, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and stimulating menstrual flow, and promoting diuresis and removing jaundice; the compound of glauber-salt and liquorice can relax the bowels, moisten dryness and soften hard mass, clear fire and diminish swelling, detoxify and purge heat, and relieve lung inflammatory response; the garlic has the functions of promoting qi stagnation, warming spleen and stomach, eliminating stagnation of diseases, detoxifying and killing insects, can effectively treat infantile pneumonia and is quick in effect, and the rheum officinale, the compound of glauber-salt and liquorice and the garlic are mutually compatible and have a synergistic effect on treatment of the infantile pneumonia. The preparation method disclosed by the invention is simple and easy to implement and suitable for industrial production, and the prepared traditional Chinese medicine composition is high in safety.

Description

Technical Field

[0001] This invention belongs to the field of biomedical technology, and in particular relates to a traditional Chinese medicine composition for treating pediatric pneumonia, its preparation method and application. Background Technology

[0002] Pneumonia in children is one of the most common respiratory diseases in children, occurring in all seasons. Symptoms include fever, cough, shortness of breath, difficulty breathing, and fine moist rales in the lungs. Some children may experience severe cough and wheezing without fever. Severe cases can affect the circulatory, nervous, and digestive systems, leading to corresponding clinical symptoms and seriously threatening children's health. In Traditional Chinese Medicine (TCM), childhood pneumonia falls under the category of "pneumonia and wheezing," and its pathogenesis is believed to be related to the physiological characteristics of children, such as insufficient lung capacity and weak defensive qi. External pathogens invade the lungs, causing impaired lung qi circulation, internal generation of phlegm and heat, and obstruction of the lung channels, resulting in the disease. Although there are medications for treating childhood pneumonia, Western medicine generally uses antibiotics, antiviral drugs, and even hormones for symptomatic treatment. While these methods have some efficacy, they still have drawbacks such as drug resistance, recurrence, and adverse reactions. Traditional Chinese medicine (TCM) has certain advantages in treating pediatric pneumonia. However, current TCM treatments for pediatric pneumonia suffer from problems such as long treatment times, poor efficacy, and complex formulations that make quality control difficult. Furthermore, oral administration of TCM is challenging for young infants, who are often unwilling to take medication. In addition, children are in a stage of rapid growth and development, and most of their organs are not yet fully developed, resulting in lower metabolic tolerance and tolerance to drugs. Therefore, developing a TCM composition that is rapid-acting, easily accepted by children, and achieves therapeutic effects without causing harm is a pressing technical problem that needs to be solved. Summary of the Invention

[0003] Therefore, the purpose of this invention is to provide a traditional Chinese medicine composition for treating pediatric pneumonia, its preparation method, and its application.

[0004] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0005] This invention provides a traditional Chinese medicine composition for treating pediatric pneumonia, comprising the following raw materials in parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate, and 10-30 parts garlic.

[0006] Preferably, the raw materials include the following parts by weight: 7-12 parts rhubarb, 14-25 parts sodium sulfate and 13-26 parts garlic.

[0007] This invention provides a traditional Chinese medicine composition for treating pediatric pneumonia, made from the following raw materials in parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate and 10-30 parts garlic.

[0008] Preferably, the mass ratio of rhubarb, sodium sulfate, and garlic is 1:2:2.

[0009] This invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps:

[0010] Rhubarb is crushed and sieved to obtain rhubarb powder. Then, the rhubarb powder is mixed with sodium sulfate to obtain rhubarb sodium sulfate.

[0011] Crush the garlic to obtain garlic paste;

[0012] A traditional Chinese medicine composition is obtained by mixing rhubarb sodium sulfate with minced garlic.

[0013] Preferably, the mesh size of the sieve is 60 to 100 mesh.

[0014] Preferably, the particle size of the sodium sulfate is 50-70 mesh.

[0015] Preferably, the traditional Chinese medicine composition is a traditional Chinese medicine ointment.

[0016] This invention provides the application of the above-mentioned traditional Chinese medicine composition or preparation method in the preparation of pediatric pneumonia drugs.

[0017] Preferably, the sole active ingredient of the drug is the traditional Chinese medicine composition described above or the traditional Chinese medicine composition prepared by the above method.

[0018] Compared with the prior art, the present invention has the following beneficial effects:

[0019] This invention provides a traditional Chinese medicine composition for treating pediatric pneumonia, its preparation method, and its application. In this composition, rhubarb has the effects of purging stagnation, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and promoting menstruation, and promoting diuresis and relieving jaundice; sodium sulfate can purge and relieve constipation, moisten dryness and soften hard masses, clear heat and reduce swelling, detoxify and purge heat, and reduce pulmonary inflammation; garlic is pungent and has a penetrating nature, which can guide the other medicines directly to the affected area. Its functions include promoting qi circulation, warming the spleen and stomach, eliminating stagnation, detoxifying and killing parasites, and enhancing the warming, dispersing, and detoxifying effects of the medicines. Furthermore, garlic can, to a certain extent, mitigate the harshness or toxicity of certain medicines, making the overall formula more balanced and harmonious, which helps improve clinical efficacy and reduce adverse reactions. The combined use of these three compositions can effectively treat pediatric pneumonia, with rapid onset of action, and has a synergistic effect in treating pediatric pneumonia.

[0020] The preparation method of the present invention is simple and easy to implement, suitable for industrial production, and the prepared traditional Chinese medicine composition has high safety. Attached Figure Description

[0021] Figure 1 The image shows the herbal ointment prepared in Example 1. Detailed Implementation

[0022] This invention provides a traditional Chinese medicine composition for treating pediatric pneumonia, comprising the following raw materials in parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate, and 10-30 parts garlic.

[0023] In this invention, as a preferred embodiment, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 7-12 parts rhubarb, 14-25 parts sodium sulfate, and 13-26 parts garlic.

[0024] In this invention, the rhubarb has the functions of purging accumulations, clearing heat and purging fire, cooling blood and detoxifying, removing blood stasis and promoting menstruation, and promoting diuresis and relieving jaundice. The weight of the rhubarb is preferably 8 to 10 parts, more preferably 8, 9 or 10 parts. This invention does not have a special limitation on the source of rhubarb, and commercially available products in the field can be used.

[0025] In this invention, the Glauber's salt can purge and relieve constipation, moisten dryness and soften hardness, clear heat and reduce swelling, detoxify and relieve heat, and reduce lung inflammation. The weight of the Glauber's salt is preferably 15 to 20 parts, more preferably 16, 17, 18, 19 or 20 parts. This invention does not have a special limitation on the source of Glauber's salt, and commercially available products in the field can be used.

[0026] In this invention, the garlic has the functions of promoting qi circulation, warming the spleen and stomach, eliminating stagnation, and detoxifying and killing parasites. The weight of the garlic is preferably 15 to 25 parts, more preferably 16, 17, 18, 19 or 20 parts. This invention does not have any special limitation on the source of garlic, and commercially available products in the field can be used.

[0027] This invention combines rhubarb, sodium sulfate, and garlic to accelerate microcirculation at the site of inflammation, promoting rapid absorption and dissipation of inflammation.

[0028] This invention provides a traditional Chinese medicine composition for treating pediatric pneumonia, made from the following raw materials in parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate and 10-30 parts garlic.

[0029] In this invention, the preferred mass ratio of rhubarb, sodium sulfate, and garlic is 1:2:2, such as 10 parts rhubarb, 20 parts sodium sulfate, and 20 parts garlic.

[0030] This invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps:

[0031] Rhubarb is crushed and sieved to obtain rhubarb powder. Then, the rhubarb powder is mixed with sodium sulfate to obtain rhubarb sodium sulfate.

[0032] Crush the garlic to obtain garlic paste;

[0033] A traditional Chinese medicine composition is obtained by mixing rhubarb sodium sulfate with minced garlic.

[0034] In this invention, rhubarb is pulverized and sieved to obtain rhubarb powder. The pulverization can be performed using a pulverizer, and the sieve mesh size is preferably 60-100 mesh, more preferably 60-90 mesh, and even more preferably 80 mesh. After obtaining the rhubarb powder, it is mixed with sodium sulfate to obtain rhubarb-sodium sulfate powder. This invention does not have a specific limitation on the mixing method; any method known in the art can be used, such as stirring. The particle size of the sodium sulfate is preferably 50-70 mesh, more preferably 55-65 mesh, and even more preferably 60 mesh. This invention uses rhubarb powder with the above mesh size or sodium sulfate particle size to ensure that the prepared traditional Chinese medicine composition has a fine texture and is free of particles. After obtaining the rhubarb-sodium sulfate powder, garlic is crushed to obtain garlic paste. The crushing method can be selected by crushing garlic cloves with a 200-220W juicer for 2 minutes; the traditional Chinese medicine composition is a traditional Chinese medicine paste. In the above preparation method, garlic paste is used as a base, and after mixing with rhubarb-sodium sulfate powder, a traditional Chinese medicine paste is prepared. The traditional Chinese medicine composition prepared by the method of the present invention is a brown ointment with a uniform and delicate texture and good stability. It can improve the efficacy and safety of treating pediatric pneumonia. Applying the ointment externally can improve patient compliance.

[0035] This invention utilizes a traditional Chinese medicine plaster applied to the skin. The plaster is slowly released into the bloodstream through the skin's capillaries, bypassing liver metabolism and reducing the burden on the gastrointestinal tract. It acts directly on the affected area to exert its effects. The effects are complementary and mutually reinforcing, and the raw materials are inexpensive, economical, and convenient.

[0036] This invention provides the application of the above-mentioned traditional Chinese medicine composition or preparation method in the preparation of pediatric pneumonia drugs.

[0037] In this invention, the sole active ingredient of the drug is the aforementioned traditional Chinese medicine composition or the traditional Chinese medicine composition obtained by the preparation method. The traditional Chinese medicine composition of this invention can effectively treat pediatric pneumonia patients and also relieve symptoms such as fever, cough, sputum production, and wheezing; it can also be used as an adjunct in the comprehensive treatment of severe pneumonia to help accelerate the improvement of symptoms. The traditional Chinese medicine composition of this invention is a traditional Chinese medicine ointment. The method of using the ointment is as follows: clean the skin of the child at the application site, take 100g of ointment and evenly apply it to the lung acupoints on both sides (located on the back, below the spinous process of the 3rd thoracic vertebra, 1.5 cun lateral to the midline), fix it with a large adhesive plaster, once a day, for 4-6 hours each time.

[0038] The herbal ointment of the present invention is directly applied to the lung acupoint, which has the following advantages: (1) Significant local efficacy: It can form a high concentration of herbal ointment at the lesion site and exert its effect directly. Through transdermal absorption, it directly reaches the lesion site and quickly eliminates lung inflammation, promotes sputum absorption, and improves lung symptoms. (2) Reduced systemic adverse reactions: Compared with oral drugs, the herbal ointment acts directly on the local skin, reducing the impact of the herbal ointment on other organs of the body and reducing the risk of adverse reactions, especially suitable for children. The herbal ointment of the present invention also has a multi-pathway comprehensive effect, as follows: (1) Transdermal absorption: The skin has an absorption function. The effective ingredients in the herbal ointment can penetrate into the blood circulation through the epidermis and exert a systemic therapeutic effect. It can promote the transdermal absorption of other drug ingredients and enhance the efficacy. (2) Meridian regulation: The human meridians are interconnected with the internal organs. When the herbal ointment is applied to the lung acupoint, it can stimulate the meridians, regulate the flow of qi and blood and the function of the internal organs, and achieve the purpose of overall treatment of pediatric pneumonia. The herbal ointment of this invention also has sustained-release and long-lasting effects, specifically as follows: (1) Continuous release: The base of the herbal ointment allows for slow release of the drug, prolonging the local action time of the drug and maintaining a stable blood drug concentration, thereby exerting a long-lasting therapeutic effect. (2) Reduced medication frequency: Due to its long-lasting effect, compared to oral medications which require frequent administration, the herbal ointment generally only needs to be changed once a day or every few days, making it convenient and painless to use, thus improving the patient's compliance. The herbal ointment of this invention has a synergistic effect.

[0039] In this invention, the herbal ointment can be used in combination with other traditional Chinese medicine therapies such as acupuncture and massage to exert a synergistic effect. For example, the ointment used after massage can further promote local blood circulation and enhance the therapeutic effect of the massage. The herbal ointment of this invention avoids the gastrointestinal irritation and other problems that may occur with oral medications, making it a relatively safe and effective treatment.

[0040] The traditional Chinese medicine composition prepared by the above method is a herbal ointment, which avoids the difficulty of oral administration in children and gastrointestinal irritation, and reduces the first-pass effect of the liver. It penetrates through the skin and is conducted to the lungs via meridians to exert a systemic therapeutic effect, exhibiting high safety and reducing the risk of adverse drug reactions.

[0041] The specifications of the herbal ointment of this invention are as follows: Each bag contains a net weight of 100g, sufficient for approximately one day's use at two lung acupoints. Packaging: The ointment is packaged in resealable bags to ensure good sealing and prevent contamination and spoilage. A label with clear information such as product name, ingredients, usage and dosage, and precautions is affixed to the outside of the bag.

[0042] Precautions for the herbal ointment of this invention:

[0043] (1) This product is contraindicated for those with broken skin, ulcers, or infections at the application site.

[0044] (2) This ointment is contraindicated for those who are allergic to any of its ingredients, and should be used with caution by those with allergic constitutions.

[0045] (3) During medication, the child should rest, avoid strenuous exercise, eat a light diet, and avoid spicy, greasy and cold foods.

[0046] (4) The herbal ointment of the present invention is for external use only and is prohibited from being taken internally.

[0047] In this invention, unless otherwise specified, all raw material components are commercially available products well known to those skilled in the art.

[0048] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.

[0049] Example 1

[0050] A traditional Chinese medicine composition for treating pediatric pneumonia, made from the following raw materials by weight:

[0051] 10g rhubarb, 20g sodium sulfate, and 20g garlic.

[0052] A method for preparing a traditional Chinese medicine ointment for treating pediatric pneumonia, comprising the following steps:

[0053] (1) Crush rhubarb into powder and pass it through an 80-mesh sieve to obtain rhubarb powder;

[0054] (2) Mix 10g of rhubarb powder with 20g of 60-mesh sodium sulfate to obtain rhubarb sodium sulfate;

[0055] (3) Process the garlic with a 220W juicer for 2 minutes to obtain garlic paste;

[0056] (4) Mix 30g of rhubarb sodium sulfate with 20g of garlic paste to obtain a Chinese medicine paste.

[0057] The herbal ointment prepared in this embodiment was subjected to appearance and specified tests. The appearance test method involved directly observing the color and shape of the ointment, checking for uniformity of color and the presence of lumps. The texture test method involved touching and applying the ointment to assess its smoothness and viscosity, checking for smoothness and uniformity, and the absence of rough particles or lumps.

[0058] After testing and combination Figure 1 As shown, the herbal ointment prepared in this embodiment is a brown ointment with uniform color, uniform and delicate texture, and no particles.

[0059] Example 2

[0060] A traditional Chinese medicine composition for treating pediatric pneumonia, made from the following raw materials by weight:

[0061] 5g rhubarb, 10g sodium sulfate, and 10g garlic.

[0062] A method for preparing a traditional Chinese medicine ointment for treating pediatric pneumonia, comprising the following steps:

[0063] (1) Crush rhubarb into powder and pass it through an 80-mesh sieve to obtain rhubarb powder;

[0064] (2) Mix 5g of rhubarb powder with 10g of 60-mesh sodium sulfate to obtain rhubarb sodium sulfate;

[0065] (3) Grind the garlic in a 200W juicer for 2 minutes to obtain garlic paste;

[0066] (4) Mix 15g of rhubarb sodium sulfate with 10g of garlic paste to obtain a Chinese medicine paste.

[0067] Example 3

[0068] A traditional Chinese medicine composition for treating pediatric pneumonia, made from the following raw materials by weight:

[0069] 15g rhubarb, 30g sodium sulfate, and 30g garlic.

[0070] A method for preparing a traditional Chinese medicine ointment for treating pediatric pneumonia, comprising the following steps:

[0071] (1) Crush rhubarb into powder and pass it through an 80-mesh sieve to obtain rhubarb powder;

[0072] (2) Mix 15g of rhubarb powder with 30g of 60-mesh sodium sulfate to obtain rhubarb sodium sulfate;

[0073] (3) Grind the garlic in a 200W juicer for 2 minutes to obtain garlic paste;

[0074] (4) Mix 45g of rhubarb sodium sulfate with 30g of garlic paste to obtain a Chinese medicine paste.

[0075] Experimental Example 1

[0076] This study employed a randomized, double-blind, parallel-controlled design. Inclusion criteria included: 1. intermittent cough lasting more than 3 days; 2. moist rales or wheezing on lung auscultation; 3. chest X-ray showing shadows. Children with pneumonia were randomly assigned to either the experimental or control group, with 40 cases in each group. In the experimental group, 100g of the herbal ointment prepared in Example 1 was evenly applied to both sides of the Lung Shu acupoints (located on the back, below the spinous process of the 3rd thoracic vertebra, 1.5 cun lateral to the midline) after cleaning the skin at the application site. The ointment was then fixed with a large adhesive patch. This was done once daily for 10-20 minutes each time, with 5 days constituting one course of treatment, for a total of two courses. The control group had their skin cleaned at the application site, and the acupoint patches (purchased from Tianjin Haiaos Technology Co., Ltd., specification E, production license number: Jin Yao Jian Xie Sheng Chan Xu 20100144) were applied to the acupoints of Feishu, Xinshu, and Geshu. One patch was applied daily for 4-6 hours each time, and one course of treatment lasted for 5 days. A total of 2 courses of treatment were administered.

[0077] Observational indicators: Primary observational indicators included the improvement of clinical symptoms and signs (fever, cough, sputum production, wheezing, lung rales, etc.) and chest X-ray results. Secondary observational indicators included changes in laboratory indicators such as complete blood count and C-reactive protein, as well as the child's quality of life score.

[0078] Efficacy evaluation criteria: The efficacy evaluation criteria were formulated based on the "Standards for Diagnosis and Efficacy of Diseases and Syndromes in Traditional Chinese Medicine". Cure: Clinical symptoms and signs disappear, and chest X-ray examination returns to normal; Significant effect: Clinical symptoms and signs significantly improve, and chest X-ray examination shows that most of the inflammation has been absorbed; Effective: Clinical symptoms and signs improve somewhat, and chest X-ray examination shows that the inflammation has been partially absorbed; Ineffective: Clinical symptoms and signs do not improve or worsen, and chest X-ray examination shows no change or worsening of the inflammation.

[0079] Overall effective rate = (number of cured cases + number of cases with significant improvement + number of cases with improvement) / total number of cases × 100%.

[0080] Safety evaluation: Observe whether the children experience adverse reactions such as skin allergies, itching, redness and swelling during the experiment, record the occurrence time, symptoms, severity and outcome of adverse reactions, and evaluate the safety of the ointment of this invention.

[0081] Table 1. Treatment effects of different groups at different number of days.

[0082]

[0083] Starting from 3 days of application of the herbal plaster prepared in Example 1, clinical symptoms and signs significantly improved, with a total effective rate of 100%. Chest X-ray examination showed partial absorption of inflammation, demonstrating its effectiveness in treating pediatric pneumonia. After 10 days of treatment, the pediatric pneumonia symptoms completely disappeared, achieving a cure rate of 100%. In contrast, the control group showed some improvement in clinical symptoms after 5 days of acupoint application treatment, but after 10 days, cough persisted, with a small amount of moist rales in the lungs. X-ray examination showed a significant reduction in the area of ​​patchy shadows, indicating a significantly prolonged course of illness and slower symptom disappearance compared to the experimental group. Furthermore, after treatment with the herbal plaster of Example 1, no adverse reactions such as skin allergies, itching, or redness occurred in the children. However, after treatment with the acupoint application patch in the control group, some children experienced adverse skin reactions such as skin allergies, itching, and redness on the first day of application, leading to interrupted or intermittent application, which was detrimental to disease recovery.

[0084] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for treating pediatric pneumonia, characterized in that, The ingredients include the following parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate, and 10-30 parts garlic.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The ingredients include the following parts by weight: 7-12 parts rhubarb, 14-25 parts sodium sulfate, and 13-26 parts garlic.

3. A traditional Chinese medicine composition for treating pediatric pneumonia, characterized in that, It is made from the following ingredients in parts by weight: 5-15 parts rhubarb, 10-30 parts sodium sulfate and 10-30 parts garlic.

4. The traditional Chinese medicine composition according to any one of claims 1 to 3, characterized in that, The mass ratio of rhubarb, sodium sulfate, and garlic is 1:2:

2.

5. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 4, characterized in that, Includes the following steps: Rhubarb is crushed and sieved to obtain rhubarb powder. Then, the rhubarb powder is mixed with sodium sulfate to obtain rhubarb sodium sulfate. Crush the garlic to obtain garlic paste; A traditional Chinese medicine composition is obtained by mixing rhubarb sodium sulfate with minced garlic.

6. The preparation method according to claim 5, characterized in that, The sieve mesh size is 60-100 mesh.

7. The preparation method according to claim 5, characterized in that, The particle size of the sodium sulfate is 50-70 mesh.

8. The preparation method according to claim 5, characterized in that, The herbal composition is a herbal ointment.

9. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4 or the preparation method according to any one of claims 5 to 8 in the preparation of pediatric pneumonia drugs.

10. The application according to claim 9, characterized in that, The sole active ingredient of the drug is the traditional Chinese medicine composition according to any one of claims 1 to 4 or the traditional Chinese medicine composition obtained by the preparation method according to any one of claims 5 to 8.

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