Diabetes nutrition intervention system based on four-dimensional theory

Abstract

The invention discloses a diabetes nutrition intervention system based on a four-dimensional theory, which belongs to the field of nutrition intervention and comprises a precise nutrition intervention module, a metabolic rhythm regulation module, an intestinal flora optimization module, an emotional and lifestyle management module, a data acquisition and analysis module and a scheme regulation module. Through the synergistic effect of four dimensions of precise nutrition intervention, metabolic rhythm regulation, intestinal flora optimization and emotional and lifestyle management, the limitation of a single intervention mode is broken through, and systematic regulation of blood sugar is realized from multiple aspects of nutrition metabolism, biological clock regulation, intestinal microecological balance, physical and mental states and the like; compared with traditional single diet or exercise intervention, the insulin sensitivity can be more remarkably improved, and the blood sugar fluctuation range is reduced; according to the invention, food intervention is taken as a core, and life style adjustment is combined, so that the side effects of gastrointestinal reaction, liver and kidney function burden and the like possibly caused by long-term drug treatment are avoided.

Description

Technical Field

[0001] This invention relates to the field of nutritional intervention technology, and in particular to a diabetes nutritional intervention system based on four-dimensional theory. Background Technology

[0002] Diabetes mellitus, a prevalent chronic metabolic disease worldwide, continues to rise in incidence due to modern lifestyles, posing a significant threat to public health. Current clinical interventions for diabetes primarily rely on medication, including insulin injections and oral hypoglycemic agents (such as metformin and acarbose). However, long-term drug dependence can lead to side effects such as gastrointestinal reactions and increased burden on liver and kidney function, and it is difficult to fundamentally improve the patient's metabolic disorder.

[0003] Meanwhile, existing lifestyle intervention programs have significant limitations: First, most programs focus on a single dimension (such as simply controlling diet or emphasizing exercise), lacking a systematic integration of nutrition, metabolic rhythm, gut microbiota, and physical and mental state related to blood glucose metabolism, resulting in fragmented intervention effects; Second, they lack personalization, often using uniform dietary templates (such as fixed calorie ratios) and ignoring individual differences (such as age, disease course, complications, and TCM constitution), leading to low patient compliance and difficulty in long-term adherence; Third, existing dietary interventions mostly rely on a simple high-GI / low-GI classification, without deeply integrating the synergistic effects of active ingredients in food (such as anti-inflammatory substances and probiotics) and human metabolic mechanisms, resulting in limited blood sugar control effects.

[0004] Furthermore, modern medical research has confirmed that blood glucose regulation is a complex systems engineering process involving nutrient metabolism, circadian rhythms, gut microbiota, and neuroendocrine function. Dr. Anne Fleck's "food pharmacology" theory reveals the precise regulatory effect of specific foods on blood glucose; Professor Zenji Makita's "time-restricted diet" research confirms the influence of metabolic rhythms on insulin sensitivity; Dr. Jesse Anzospe's "metabolic repair" model emphasizes the link between gut microbiota and blood glucose; and traditional Chinese medicine theories such as "medicine and food sharing the same origin," "meridian flow," and "soothing the liver and relieving stagnation" provide millennia of practical wisdom for multi-dimensional intervention. However, currently, no technological solution can organically integrate the above-mentioned cutting-edge theories with the wisdom of traditional Chinese medicine to form a diabetes nutritional intervention system that is scientific, systematic, and personalized.

[0005] Therefore, a diabetes nutritional intervention system based on the four-dimensional theory is needed to address the shortcomings of existing technologies, improve the effectiveness of diabetes management, and reduce drug dependence. This has significant clinical value and social significance. Summary of the Invention

[0006] To address the shortcomings of existing technologies, this invention provides a diabetes nutritional intervention system based on four-dimensional theory, which solves the problems mentioned in the background section.

[0007] Technical Solution: To solve the above-mentioned technical problems, according to one aspect of the present invention, more specifically, the present invention provides a diabetes nutritional intervention system based on four-dimensional theory, comprising a precision nutritional intervention module, a metabolic rhythm regulation module, a gut microbiota optimization module, an emotional and lifestyle management module, a data acquisition and analysis module, and a program adjustment module:

[0008] Precision Nutrition Intervention Module

[0009] Originating from the theory of "food as medicine" and the traditional Chinese medicine concept of "medicine and food sharing the same origin," its core is a triple sugar control mechanism of "fiber sustained release - protein regulation - plant active ingredients," including:

[0010] Meal design logic:

[0011] Ingredient selection: Low-GI foods (such as whole grains, legumes, and low-GI vegetables) are paired with anti-inflammatory ingredients (such as blueberries and spinach) and high-quality protein (such as eggs and chicken breast), and medicinal and edible ingredients such as yam and poria cocos are added;

[0012] Nutritional design: Control the total amount of carbohydrates (breakfast <15g, lunch 30-40g, dinner 20-30g), prioritize complex carbohydrates, and balance the ratio of protein to fat;

[0013] Cooking guidelines: Primarily use low-temperature (≤150℃) frying, steaming, and cold dishes to avoid high oil and sugar content and preserve the fiber and active ingredients of the ingredients.

[0014] Metabolic rhythm regulation module

[0015] Based on research on "time-restricted eating" and the theory of "meridian flow," an 8-12 hour eating window is set daily (e.g., 7:00-17:00), with breakfast at 7:00-9:00 (when the stomach meridian is dominant), lunch at 12:00-13:00 (when the heart meridian is dominant), and dinner at 17:00-18:00 (when the kidney meridian is dominant), to repair insulin sensitivity and enhance metabolic efficiency.

[0016] Gut microbiota optimization module

[0017] Integrating the "metabolic repair" model with the traditional Chinese medicine concept of "spleen and stomach regulation," this approach improves the gut microbiota through a diet high in fiber (whole grains, vegetables) and probiotics (yogurt, natto), while also using herbs such as Codonopsis pilosula and Atractylodes macrocephala to regulate the spleen and stomach and enhance nutrient absorption.

[0018] Emotional and Lifestyle Management Module

[0019] Integrating the "insulin resistance reversal" strategy and the "liver-soothing and depression-relieving" concept, this product uses meditation and yoga to regulate stress, along with 150 minutes of moderate-intensity aerobic exercise (brisk walking, swimming) and 2-3 strength training sessions per week, to reduce stress-induced hyperglycemia and promote physical and mental balance.

[0020] Data Acquisition and Analysis Module

[0021] User data will be collected and analyzed in multiple dimensions at the following frequencies to generate an intervention effectiveness evaluation report:

[0022] Daily blood glucose tests were collected: fasting blood glucose (30 minutes before breakfast) and blood glucose 2 hours after meals (2 hours after breakfast, lunch, and dinner), and the blood glucose fluctuation curve was recorded.

[0023] Weekly data collection: Dietary adherence (recording food types, actual intake, and whether cooking methods meet the plan requirements through a food diary), and exercise completion (exercise type, actual duration, and intensity self-assessment, such as brisk walking pace and strength training load).

[0024] Every two weeks, the following data were collected: emotional state (using the Self-Rating Stress Scale, with a score of 1-10 to quantify stress level) and sleep quality (sleep onset time, sleep duration, and number of times the patient woke up during the night);

[0025] Monthly data collection includes: glycated hemoglobin (HbA1c) levels, medication adjustments (drug type, dosage changes), and anthropometric data such as weight and waist circumference.

[0026] Through the integrated analysis of the above data, the evaluation indicators include: blood glucose control target achievement rate (the percentage of days with fasting blood glucose <7.0 mmol / L and 2-hour postprandial blood glucose <10.0 mmol / L), dietary plan adherence (the percentage of meals that meet the design requirements), exercise goal completion rate, and gut microbiota detection indicators (such as the Bifidobacterium / Escherichia coli ratio, tested once every 3 months), etc., to provide a quantitative basis for optimizing the intervention plan.

[0027] Solution Adjustment Module

[0028] Based on the evaluation results of the data acquisition and analysis module, the four intervention modules are dynamically optimized according to the following logic, with the optimization cycle synchronized with the data acquisition frequency:

[0029] Daily adjustments: If blood glucose 2 hours after a meal is >10.0 mmol / L for 3 consecutive days, temporarily adjust the total amount of carbohydrates in the corresponding meal the next day (reduce by 5-10g), or shorten the interval between the meal and the next meal (30 minutes earlier).

[0030] Weekly adjustments: If dietary adherence is <70%, adjust the taste of meals based on user feedback (e.g., add low-GI seasoning ingredients) or simplify cooking steps; if exercise completion rate is <60%, reduce exercise intensity (e.g., change brisk walking to walking) or split exercise duration (e.g., break 150 minutes / week into 30 minutes / day x 5 days);

[0031] Adjust every 2 weeks: If the stress self-assessment scale score is consistently >7, add stress management methods (such as adding 5 minutes of deep breathing training to meditation);

[0032] Monthly adjustments: If glycated hemoglobin decreases by <0.5%, optimize the food combination in the precision nutrition intervention module (e.g., increase the proportion of high-fiber foods to 20%); if there is no improvement in insulin sensitivity test indicators, shorten the eating window by 1 hour (e.g., adjust from 10 hours to 9 hours).

[0033] By making dynamic adjustments in a step-by-step manner, we ensure that the intervention plan always adapts to changes in the user's physical condition, thereby improving the long-term effectiveness.

[0034] The beneficial effects of the diabetes nutritional intervention system based on four-dimensional theory of this invention are as follows:

[0035] (1) This invention breaks through the limitations of a single intervention mode by synergistic effects of four dimensions: precise nutritional intervention, metabolic rhythm regulation, gut microbiota optimization and emotional and lifestyle management. It achieves systematic regulation of blood sugar from multiple levels, including nutritional metabolism, biological clock regulation, gut microbiota balance and physical and mental state. Compared with traditional single diet or exercise intervention, it can more significantly improve insulin sensitivity and reduce the amplitude of blood sugar fluctuations.

[0036] (2) This invention takes food intervention as the core and combines it with lifestyle adjustment to avoid the side effects such as gastrointestinal reactions and liver and kidney function burden that may be caused by long-term drug treatment. It is suitable for patients with prediabetes, type 2 diabetes and insulin resistance who have poor drug tolerance or wish to reduce drug dependence, thus improving the safety and tolerability of the intervention.

[0037] (3) Through the data collection and analysis module and the scheme adjustment module, this invention can dynamically optimize intervention measures such as meal plan, eating time and exercise intensity according to individual differences such as age, gender, weight, disease, eating habits, and TCM constitution of users. Moreover, the meal design takes into account both taste and nutrition, and the exercise and stress regulation methods are simple and easy to implement, which solves the problem of low compliance and difficulty in long-term adherence of traditional uniform intervention plans. Attached Figure Description

[0038] The present invention will now be described in further detail with reference to the accompanying drawings and specific implementation methods.

[0039] Figure 1 This is a schematic diagram of the structure of the present invention. Detailed Implementation

[0040] The present invention will be described in detail below with reference to the accompanying drawings and embodiments. It should be noted that, unless otherwise specified, the embodiments and features described in the present application can be combined with each other.

[0041] To make the technical solution of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0042] Example 1

[0043] Reference Figure 1 A diabetes nutritional intervention system based on four-dimensional theory, and a diabetes nutritional intervention breakfast program based on four-dimensional theory:

[0044] 1. Meal composition

[0045] Main dish: Carrot and egg pancake (100g coarsely grated carrot + 1 egg + 10g whole wheat flour, or 5g almond flour)

[0046] Beverage: 250ml unsweetened freshly ground soy milk (with 5g chia seeds)

[0047] Side dish: 50g of cold spinach salad (seasoned with 2ml sesame oil)

[0048] 2. Intervention Mechanism

[0049] Precision nutrition intervention:

[0050] Low GI design: whole wheat flour (GI=45) + carrot (GI=35), total carbohydrates <15g, glucose absorption is slowed down through soluble fiber (pectin);

[0051] Food and medicine share the same origin: Carrots (strengthen the spleen and aid digestion) + soy milk (moisten dryness and replenish deficiency), combined with chia seeds (β-glucan) to enhance blood sugar control.

[0052] Metabolic rhythm regulation: Breakfast time is set between 7:00 and 9:00 (which aligns with the "stomach meridian is dominant during the Chen hour" in Traditional Chinese Medicine), matching the daily 10-hour eating window (7:00-17:00) to repair insulin sensitivity.

[0053] Gut microbiota optimization: Soy milk contains plant protein and oligosaccharides, which promote the proliferation of beneficial bacteria in the gut; spinach dietary fiber (2.8g / 100g) improves the gut microecology.

[0054] 3. Key points of implementation

[0055] Cooking: Fry at 120℃ with a little oil, avoiding the addition of sweet chili sauce (sugar content >10g / serving);

[0056] Personalized adjustments: For those with flour sensitivity, use oat bran (4g / 10g of beta-glucan); for those with excessive stomach acid, blanch carrot shreds to soften them.

[0057] Example 2

[0058] Reference Figure 1A diabetes nutritional intervention system based on four-dimensional theory, and a Chinese meal plan for diabetes nutritional intervention based on four-dimensional theory:

[0059] 1. Meal composition

[0060] Staple food: Mixed grain rice (50g brown rice + 20g oats + 30g quinoa)

[0061] Main dish: 100g steamed sea bass + 200g garlic broccoli

[0062] Soup: Yam and Lotus Seed Soup (50g yam + 15g lotus seeds + 30g lean pork)

[0063] 2. Intervention Mechanism

[0064] Precision nutrition intervention:

[0065] Low-GI combination: Mixed grain rice (GI=50) + sea bass (high-quality protein, containing Omega-3 anti-inflammatory components), broccoli (2.6g dietary fiber / 100g) to slow down carbohydrate absorption;

[0066] Food and medicine share the same origin: yam (strengthens the spleen and stomach) + lotus seeds (nourishes the heart and calms the mind), which conforms to the TCM theory of "spleen and stomach regulation".

[0067] Metabolic rhythm regulation: Lunch should be eaten between 12:00 and 13:00 (according to the Chinese medicine concept of "noon when the heart meridian is dominant"), 4-5 hours apart from breakfast, to avoid insulin fluctuations.

[0068] Gut microbiota optimization: Quinoa contains resistant starch, which promotes the growth of bifidobacteria in the gut; broccoli contains indole-3-carbinol, which regulates intestinal immunity.

[0069] 3. Key points of implementation

[0070] Cooking method: Steaming (≤100℃) instead of frying; salt content ≤3g.

[0071] Avoid pairing with refined flour steamed buns (GI=85) or braised dishes (high in sugar and oil).

[0072] Example 3

[0073] Reference Figure 1 A diabetes nutritional intervention system based on four-dimensional theory, and a diabetes nutritional intervention dinner program based on four-dimensional theory.

[0074] 1. Meal composition

[0075] Staple food: 40g buckwheat noodles (dry weight)

[0076] Main dish: Cold shredded chicken salad (80g chicken breast + 100g cucumber + 50g celery)

[0077] Side dish: Mushroom salad (50g shiitake mushrooms + 50g enoki mushrooms + 5ml olive oil)

[0078] 2. Intervention Mechanism

[0079] Precision nutrition intervention:

[0080] Low-GI options: Buckwheat noodles (GI=40, contains rutin for antioxidants) + chicken breast (high protein, fat content <5%), celery (1.4g dietary fiber / 100g) to enhance satiety;

[0081] Food and medicine from the same source: Shiitake mushrooms (strengthening the body and replenishing deficiencies) + Enoki mushrooms (benefiting the liver and stomach), together help to "soothe the liver and relieve depression".

[0082] Metabolic rhythm regulation: Dinner should be eaten between 5:00 PM and 6:00 PM (when the kidney meridian is dominant in Traditional Chinese Medicine), 3 hours before bedtime, which falls within the fasting window for timed eating (6:00 PM to 7:00 AM the next day), thus reducing nighttime blood sugar fluctuations.

[0083] Emotional and lifestyle management: Perform 15 minutes of Tai Chi exercise (low intensity, to regulate stress) 1 hour after meals, combined with the concept of "soothing the liver" to promote physical and mental balance.

[0084] 3. Key points of implementation

[0085] Cooking: Rinse buckwheat noodles with cold water after cooking (to reduce starch gelatinization); do not add salad dressing (high in sugar) when making cold shredded chicken salad.

[0086] Special note: Patients with kidney disease should reduce chicken breast to 50g (to control total protein intake) and replace mushrooms with winter melon (low in potassium).

[0087] Supplemental effect verification

[0088] Clinical data show that by combining breakfast, lunch, and dinner regimens for synergistic intervention:

[0089] After 8 weeks of intervention, patients with type 2 diabetes experienced an average decrease of 2.3 mmol / L in 2-hour postprandial blood glucose and a decrease of 0.8%-1.2% in glycated hemoglobin (HbA1c).

[0090] The number of Bifidobacteria in the gut microbiota increased 2.1 times, and insulin sensitivity improved by 30%.

[0091] 92% of users reported that it was "easy to implement" and had no side effects from drug interactions.

[0092] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements all fall within the scope of protection of the present invention. Therefore, the scope of protection of this patent should be determined by the appended claims.

Claims

1. A diabetes nutritional intervention system based on a four-dimensional theory, comprising a precision nutritional intervention module, a metabolic rhythm regulation module, a gut microbiota optimization module, and an emotional and lifestyle management module, characterized in that: The precision nutrition intervention module is based on Dr. Anne Fleck's "food as medicine" theory and combined with the traditional Chinese medicine concept of "medicine and food sharing the same origin". It optimizes blood sugar metabolism through low-GI diet, anti-inflammatory food combination and personalized recipe customization. The precision nutrition intervention module includes differentiated meal plans for breakfast, lunch and dinner, following the triple blood sugar control mechanism of "fiber slow release - protein regulation - plant active ingredients". The metabolic rhythm regulation module is based on Professor Zenji Makita's research on "time-restricted eating" and combined with the theory of "meridian flow" in traditional Chinese medicine. It adjusts the eating time by setting an 8-12 hour eating window each day, thereby repairing insulin sensitivity and enhancing metabolic efficiency. The gut microbiota optimization module integrates Dr. Jesse Anzospe's "metabolic repair" model with the traditional Chinese medicine theory of "spleen and stomach regulation," using a high-fiber + probiotic diet to improve the gut microecology and enhance nutrient absorption. The emotional and lifestyle management module integrates Mizuno Masato's "insulin resistance reversal" strategy with the traditional Chinese medicine concept of "soothing the liver and relieving depression," and promotes physical and mental balance by reducing stress-induced hyperglycemia through stress regulation and scientific exercise.

2. The diabetes nutritional intervention system based on four-dimensional theory according to claim 1, characterized in that, The meal design logic of the precision nutrition intervention module includes: Ingredient selection: Prioritize ingredients with low GI (≤55), high fiber (≥5g / 100g), containing anti-inflammatory active ingredients and high-quality protein (biological value ≥80), and add food-medicine homology ingredients based on TCM constitution differentiation; Formula design: The energy supply ratio of carbohydrates, protein, and fat is 45%-50%, 20%-25%, and 25%-30%, respectively, with complex carbohydrates being the main component; Cooking guidelines: Use low temperature (≤150℃), low oil (≤10g / meal), and low salt (≤5g / day) to avoid Maillard reaction and the formation of advanced glycation end products.

3. The diabetes nutritional intervention system based on four-dimensional theory according to claim 1, characterized in that, The specific breakfast, lunch, and dinner meal plans of the precision nutrition intervention module are as follows: Breakfast: Combination of "low-GI staple food + high-quality protein + soluble fiber", total carbohydrates <15g, eaten between 7:00-9:00; Chinese meal: Combination of "complex carbohydrates + anti-inflammatory protein + high-fiber vegetables", total carbohydrates 30-40g, meal time 12:00-13:00; Dinner: A combination of "ultra-low GI staple food (GI≤40) + low-fat protein + mushrooms" with a total carbohydrate intake of 20-30g. The meal should be eaten between 17:00 and 18:00, and at least 3 hours before bedtime.

4. The diabetes nutritional intervention system based on four-dimensional theory according to claim 1, characterized in that, It also includes a data acquisition and analysis module and a scheme adjustment module: The data collection and analysis module is used to collect user data and evaluate intervention effects at the following frequencies: daily fasting and 2-hour postprandial blood glucose levels; weekly collection of diet adherence and exercise completion; bi-weekly collection of emotional state; and monthly collection of glycated hemoglobin levels and medication adjustments. Based on the analysis results from the data collection and analysis module, the plan adjustment module dynamically optimizes the measures of the four intervention modules in real time, with the optimization cycle synchronized with the data collection frequency.

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