Compound eye laser ablation catheter, laser ablation device and control method thereof

Abstract

The invention relates to an ablation catheter in an in-vivo laser ablation system, in particular to a compound eye laser ablation catheter, a laser ablation device and a control method of the laser ablation device. In order to overcome the defects that in an existing laser ablation technology, normal saline for cooling cannot be quantitatively controlled, local blood vessels are prone to being damaged in the ablation process, or an imaging device arranged at the head end of a catheter causes reduction of laser transmission efficiency and energy, and the ablation effect is affected due to the poor imaging monitoring effect, normal saline for cooling cannot be quantitatively controlled. The compound eye laser ablation catheter comprises a catheter body, the catheter body comprises a catheter inner cavity, a light transmission optical fiber layer and a catheter wrapping layer, the light transmission optical fiber layer comprises a plurality of light transmission optical fibers and heat conduction layers filled among the light transmission optical fibers, and a guide wire and a temperature sensor are arranged in the catheter inner cavity; an imaging module is arranged on the catheter wrapping layer and comprises at least two compound eye imaging assemblies, and the compound eye imaging assemblies are used for conducting real-time imaging on the ablation part and transmitting the image to the outside.

Description

TECHNICAL FIELD

[0001] The present application relates to an ablation catheter in an in-vivo laser ablation system, in particular to a compound eye laser ablation catheter, a laser ablation device and a control method thereof. BACKGROUND

[0002] Cardiovascular disease is an important disease that threatens human health worldwide, and atherosclerosis is a chronic, progressive and systemic vascular disease that mainly involves large and medium-sized arteries such as the aorta, coronary artery, lower limb artery and cerebral artery. Atherosclerosis causes stenosis of blood vessels throughout the body, inducing the occurrence of acute myocardial infarction, acute stroke and peripheral tissue ischemic injury, and its high incidence, high disability rate, high mortality and poor prognosis bring heavy burden to patients, families and society. At present, the mainstream treatment methods for atherosclerosis, a chronic disease, include drug therapy, mechanical thrombectomy, ultrasound thrombolysis, stent implantation and laser ablation. Compared with traditional treatment methods, laser ablation has the advantages of small surgical incision, short postoperative recovery time, high repeatability and high precision. Because the wavelength of ultraviolet laser is short, the absorption rate in the tissue is high, and it mainly relies on the extremely high peak power of pulsed laser to produce a micro-explosion effect for ablation. The heat generated by the interaction between the tissue and the laser is very small, thereby greatly reducing the damage to the surrounding tissue caused by heat diffusion effect. Therefore, the ablation technology can effectively ablate the thrombus and plaque in the blood vessel through photochemical, photothermal and photo-mechanical effects. However, at present, the operator usually uses physiological saline for cooling according to surgical experience during the operation, which cannot be quantitatively controlled and is easy to cause local vascular injury during the ablation process. In addition, traditional imaging methods such as OCT imaging and ultrasonic imaging can only set the imaging device at the head end of the catheter, which leads to a reduction in laser transmission efficiency and energy, and the water vapor and tissue fragments generated during ablation affect the head-end imaging, resulting in poor imaging monitoring effect and affecting the ablation effect. SUMMARY

[0003] The purpose of the present application is to solve the problems in the prior art laser ablation technology, such as the inability to quantitatively control the physiological saline used for cooling, which is easy to cause local vascular injury during the ablation process, or the imaging device set at the head end of the catheter, which leads to a reduction in laser transmission efficiency and energy, and the poor imaging monitoring effect affecting the ablation effect, and to provide a compound eye laser ablation catheter, a laser ablation device and a control method thereof.

[0004] To achieve the above-mentioned purpose, the technical solution provided by the present application is as follows:

[0005] An ommatidium laser ablation catheter comprises a catheter body, the catheter body comprising a guide wire, a light transmission fiber layer for transmitting pulsed laser, and a catheter cladding layer arranged outside the light transmission fiber layer, a catheter lumen for injecting normal saline is arranged along the central axis of the light transmission fiber layer, and the guide wire is arranged on the central axis of the catheter lumen; The special point is that: it further comprises M temperature sensors and an imaging module, wherein M≥2; The light transmission fiber layer comprises a plurality of light transmission fibers and a heat conduction layer filled between the light transmission fibers, the distal end of the heat conduction layer is used for abutting a cold surface for heat conduction; The probes of the M temperature sensors are arranged in the catheter lumen along the circumference of the guide wire at the ablation end of the catheter body; The imaging module is arranged on the catheter cladding layer and close to the ablation end of the catheter body, and comprises at least two ommatidium imaging assemblies arranged uniformly along the circumference of the catheter cladding layer, the ommatidium imaging assemblies are used for real-time imaging of the ablation part and transmitting the image to the outside.

[0006] Further, the ommatidium imaging assembly comprises an ommatidium lens arranged on the side wall of the catheter cladding layer and a detector arranged corresponding to the ommatidium lens, the ommatidium lens is a microlens array arranged along an arc surface, and the microlens array comprises a plurality of microlenses arranged in a hexagonal honeycomb structure.

[0007] Definition, each of the microlenses and the six microlenses in the neighborhood thereof is a monitoring unit, and the microlenses of each monitoring unit correspond to different working wavelengths respectively.

[0008] Further, the number N of the light transmission fibers is calculated by the following formula:

[0009]

[0010] Wherein, r o is the outer radius of the light transmission fiber layer, r i is the radius of the catheter lumen, r f is the radius of the light transmission fiber, and β is the fiber filling coefficient.

[0011] Further, the ablation end of the light transmission fiber layer is provided with a protective glass cover.

[0012] The heat conduction layer is composed of heat conduction pouring glue injected into the gap between adjacent light transmission fibers.

[0013] The temperature sensor is a micro thin film temperature sensor.

[0014] A plurality of the light transmission fibers are arranged in concentric circles around the central axis, and the fiber filling coefficient is 75.7%, or a plurality of the light transmission fibers are arranged in layers from the inside to the outside in a hexagonal shape, and the fiber filling coefficient is 90.69%.

[0015] The application further provides a laser ablation device, which is characterized in that: comprising a laser light source system, an intelligent temperature control system, the compound eye laser ablation catheter and an imaging data processing system; the output end of the laser light source system is communicated with the compound eye laser ablation catheter and used for providing a laser light source; the intelligent temperature control system is connected with the temperature sensor and the laser light source system respectively and used for dynamically adjusting the output power and the repetition frequency of the laser light source system according to the temperature data monitored by the temperature sensor; the input end of the imaging data processing system is connected with the output end of the imaging module and used for receiving and processing the image formed by the imaging module and controlling the output power and the repetition frequency of the laser light source system according to the processing result and identifying the corresponding region.

[0016] Further, the compound eye imaging assembly comprises a compound eye lens arranged on the side wall of the catheter cladding and a detector, the compound eye lens is a microlens array arranged along a curved surface, and the microlens array comprises a plurality of microlenses arranged in a hexagonal honeycomb structure.

[0017] Definition, each of the microlenses and the six microlenses in the neighborhood of each of the microlenses is a monitoring unit, and the microlenses of each monitoring unit correspond to different working wavelengths arranged respectively, so as to realize large field of view multi-spectral compound eye imaging.

[0018] The detector is arranged correspondingly to the compound eye lens and used for detecting a multi-spectral image and transmitting the multi-spectral image of the ablation part to the imaging data processing system in a wireless transmission mode.

[0019] The imaging data processing system performs spectral chemical analysis on the composition of the ablation part according to the multi-spectral image.

[0020] Meanwhile, the application further provides a control method of the laser ablation device, which is characterized in that comprising the following steps:

[0021] Step 1, building the above laser ablation device;

[0022] Step 2, starting the laser light source system, the intelligent temperature control system and the imaging data processing system;

[0023] Step 3, the laser light source system works according to the preset output power and repetition frequency, and physiological saline is injected into the inner cavity of the catheter at the same time;

[0024] Step 4, adjusting the output power and the repetition frequency of the laser light source system and the speed of injecting physiological saline according to the data of the intelligent temperature control system and the imaging data processing system; the output power and the repetition frequency are reduced or increased at the same time.

[0025] Further, in step 1, the imaging module of the compound eye laser ablation catheter in the laser ablation device is used for acquiring a multi-spectral image.

[0026] The step 4 is specifically: the temperature of the ablation part is detected by a temperature sensor, and the intelligent temperature control system adjusts the output power and the repetition frequency of the laser light source system according to the temperature of the ablation part, and adjusts the speed of injecting the physiological saline;

[0027] The imaging data processing system obtains a real-time spectral curve of the current region according to the multispectral image, compares the real-time spectral curve with a spectral curve of the region in a normal state, reduces the output power and the repetition frequency of the laser light source system when the deviation is within a set threshold, and increases the speed of injecting the physiological saline at the same time, adjusts the repetition frequency to 0 when the deviation exceeds the set threshold, stops the output of the light source, and adjusts the speed of injecting the physiological saline to the highest to realize temperature reduction.

[0028] Further, in the step 4, the intelligent temperature control system adjusts the output power and the repetition frequency of the laser light source system according to the temperature of the ablation part, specifically:

[0029] When the temperature of the ablation part and the surrounding tissue is 50-55 DEG C, the output power is reduced to a low gear and the speed of injecting the physiological saline is increased, when the temperature of the ablation part and the surrounding tissue is greater than 55 DEG C, the repetition frequency is adjusted to 0, the output of the laser light source system is stopped, and the physiological saline is injected at the maximum speed to reduce the temperature.

[0030] The beneficial effects of the present application are:

[0031] 1. The compound eye imaging assembly in the compound eye laser ablation catheter of the present application is arranged on the side wall of the catheter cladding layer, and the wide-range real-time image of the blood vessel wall can be intuitively monitored through the compound eye imaging, the observation range is large, the radial area of the catheter body is reduced, the sectional area of the light transmission fiber layer is not affected, the light transmission efficiency and energy are ensured, and the compound eye imaging assembly arranged on the side wall of the catheter cladding layer also avoids the influence of water vapor and tissue fragments generated in the laser ablation process on the imaging effect.

[0032] 2. The gap of the light transmission fiber in the compound eye laser ablation catheter of the present application injects the heat-conducting pouring sealant as a heat-conducting layer, which can effectively and uniformly reduce the temperature of the ablation part, since the ablation part is ablated by the laser energy of each light transmission fiber, the gap between each adjacent light transmission fiber can conduct heat, and the temperature of the external cold surface can be adjusted in real time, so that the uniform temperature control of the ablation part is realized, the temperature in the blood vessel is always kept in a safe range to eliminate the damage to the blood vessel, and the problems of uncontrollable ablation part temperature and blood vessel damage are solved.

[0033] 3. The compound eye laser ablation catheter of the present application integrally arranges the light transmission fiber with controllable ablation end temperature, the compound eye imaging assembly, the temperature sensor and the guide wire, and after combination, they cooperate with each other to solve the problems of uncontrollable ablation part temperature, uncontrollable ablation efficiency of different plaque components, and difficult-to-detect blood vessel damage.

[0034] 4.The laser ablation device and the control method thereof can monitor the temperature of the ablation part in real time through the temperature sensor arranged in the lumen of the catheter and the intelligent temperature control system, thereby providing quantitative evaluation and analysis for the time and energy of the operator to perform plaque ablation, and solving the problem that the ablation efficiency of different plaque components is uncontrollable. Meanwhile, the imaging data processing system is combined, the output power, the repetition frequency of the laser light source system and the injection speed of the physiological saline are adjusted according to the deviation degree of the spectral curve, the accuracy of the temperature and ablation efficiency control is further improved, the tissue damage is avoided, and the output power and the repetition frequency of the laser light source system are simultaneously adjusted in two ways. BRIEF DESCRIPTION OF DRAWINGS

[0035] Figure 1 is a structural schematic diagram of an ablation end section of an embodiment of the compound eye laser ablation catheter of the present application;

[0036] Figure 2 is a sectional view along the axis of an embodiment of the compound eye laser ablation catheter of the present application;

[0037] Figure 3 is a structural schematic diagram of the arrangement of the microlens array in an embodiment of the compound eye laser ablation catheter of the present application;

[0038] Figure 4 is a structural schematic diagram of an embodiment of the laser ablation device of the present application.

[0039] BRIEF DESCRIPTION OF DRAWINGS

[0040] 1-lumen of the catheter, 2-guide wire, 3-temperature sensor, 4-light transmission optical fiber, 5-heat conduction layer, 6-catheter cladding, 7-compound eye imaging assembly, 8-protection glass cover. DETAILED DESCRIPTION

[0041] As shown in Figure 1 and Figure 2 , the compound eye laser ablation catheter of the present application comprises a catheter body and a protection glass cover 8 arranged at the ablation end of the catheter body, which is used for ablation of blood vessels or other tissues, the catheter body comprises a guide wire 2, M temperature sensors 3, a light transmission optical fiber layer and a catheter cladding 6 arranged outside the light transmission optical fiber layer, wherein M≥2, a catheter lumen 1 is arranged along the central axis of the light transmission optical fiber layer, the guide wire 2 is arranged on the central axis of the catheter lumen 1 and is used for guiding the catheter body to move to the lesion in the blood vessel, the inner side wall of the light transmission optical fiber layer is provided with a lumen wall, which is used for separating the light transmission optical fiber layer from the catheter lumen 1. The material of the catheter cladding 6 is not limited, which can be further selected according to the surgical experimental environment and the processing feasibility, and the commonly used materials at present include TPU (thermoplastic polyurethane), PEBAX (polyether block amide) and PA (polyamide) and the like.

[0042] The probes of the M temperature sensors 3 are located at the ablation end of the catheter body and are evenly arranged in the catheter lumen 1 along the circumference of the guide wire 2, for real-time sensing of the temperature distribution of the ablation part. In this embodiment, M=3, and the temperature sensors 3 are micro thin film temperature sensors.

[0043] The light transmission fiber layer is provided with a plurality of light transmission fibers 4 and a heat conduction layer 5 filled between the light transmission fibers 4, the input end of the light transmission fiber 4 is connected to an external laser light source for transmitting pulsed laser in the ultraviolet band and transmitting it to the ablation part with low loss. The heat conduction layer 5 is composed of heat conduction pouring glue injected into the gap between adjacent light transmission fibers 4, and the distal end is butted against a cold surface to realize heat conduction, so as to reduce the temperature in the blood vessel lumen and the ablation part. The lower the temperature of the cold surface, the better the heat conduction effect.

[0044] The catheter body is arranged in a multi-layer structure from inside to outside, wherein the guide wire 2 is located at the center of the catheter lumen 1, the lumen wall and the catheter cladding layer 6, and the temperature sensors are evenly arranged around the circumference of the guide wire 2. The main arrangement mode of the plurality of light transmission fibers 4 is concentric circular arrangement, which is arranged in layers from inside to outside around the lumen wall in the light transmission fiber layer, and gradually expands outward, and the number of light fibers in each layer is determined according to the specific requirements of the energy required for the ablation operation. In other embodiments, the light transmission fibers 4 can also be arranged in layers from inside to outside around the lumen wall in a hexagonal shape, the outer contours of the adjacent 6 light transmission fibers 4 of each light transmission fiber 4 form a hexagonal structure, and each light transmission fiber 4 is in equidistant contact with the adjacent 6 light fibers, further improving the light beam energy density of the catheter and reducing energy crosstalk.

[0045] The light transmission fiber 4 is a special high-damage-threshold multi-mode optical fiber, and the number N of the light transmission fiber 4 is determined according to the outer radius r o of the light transmission fiber layer, the catheter lumen radius r i , the light transmission fiber radius r f and the fiber filling coefficient β, and is calculated by the following formula:

[0046]

[0047] The filling coefficient is obtained by calculating the ratio of the sum of the effective cross-sectional areas of the light transmission fibers 4 to the cross-sectional area of the light transmission fiber layer. In this embodiment, the plurality of light transmission fibers 4 are arranged in concentric circles, and the fiber filling coefficient β can reach 75.7%. In other embodiments, when arranged in layers from inside to outside in a hexagonal shape, the fiber filling coefficient β can reach 90.69%.

[0048] According to the heat conduction formula, the heat transfer amount Q of the heat conduction pouring glue can be calculated as follows:

[0049]

[0050] Wherein, T1 is the temperature of the ablation part, T2 is the temperature of the outer cold surface, k is the thermal conductivity of the heat-conducting pouring glue, S is the end surface area of the light transmission fiber gap, and L is the length of the pouring glue.

[0051] During the cooling process, the temperature of the ablation part changes with the temperature adjustment of the outer cold surface. In addition, the catheter lumen 1 can be injected with physiological saline synchronously as a supplementary means for cooling the ablation part.

[0052] The protective glass cover 8 is arranged at the ablation end of the light transmission fiber layer and is mainly used for homogenizing the output light field of the light transmission fiber 4, avoiding the phenomenon of uneven laser light field energy, and avoiding the ablation end of the light transmission fiber 4 from adhering to tissue fragments.

[0053] As shown in Figure 2 The compound eye laser ablation catheter further comprises an imaging module for real-time imaging and monitoring the internal injury of the blood vessel and the biochemical tissue state. The imaging module comprises two compound eye imaging assemblies 7 arranged on the side wall of the catheter cladding layer 6 and close to the ablation end thereof. In the embodiment, the compound eye imaging assembly 7 is arranged as a compound eye multispectral imaging assembly, and the two compound eye multispectral imaging assemblies are uniformly distributed along the circumference of the catheter cladding layer 6 and are respectively located on the two sides of the catheter cladding layer 6.

[0054] As shown in Figure 3 The compound eye multispectral imaging assembly comprises a compound eye lens and a detector. The compound eye lens is a microlens array formed by closely arranging a plurality of microlenses in a hexagonal honeycomb structure along a curved surface. Each microlens and its six neighboring microlenses in the microlens array form a cluster eye, which serves as a monitoring unit. The microlenses of each monitoring unit correspond to different working wavelengths, denoted as λ1-λ7. The spectral bands are realized by the adjacent aperture cross-transmission of the compound eye to achieve large field multispectral compound eye imaging. The detector is arranged corresponding to the compound eye lens and is used for detecting multispectral images and transmitting the multispectral images of the ablation blood vessel to the outside through wireless transmission.

[0055] As shown in Figure 4As shown, when the compound eye laser ablation catheter is applied to an actual laser ablation operation, it is used in combination with an intelligent temperature control system, a laser light source system and an imaging data processing system to form a laser ablation device. The output end of the laser light source system is connected to the input end of the compound eye laser ablation catheter to provide a laser light source. The imaging data processing system is used to receive and process the multispectral images transmitted by the probe, and to control the output power and repetition frequency of the laser light source system according to the processing results. The present application realizes intuitive monitoring of a large range of real-time images of the ablation part in the form of compound eye imaging. The imaging data processing system performs spectral chemical analysis on the composition of the ablation part according to the multispectral images, including lipids, collagen and hemoglobin, to monitor the damage to blood vessels. At the same time, it can also analyze and identify areas with high lipid content, especially lipid core plaques related to plaque rupture leading to heart attacks.

[0056] The intelligent temperature control system is provided with signal lines between the temperature sensor 3 and the laser light source control system, and dynamically adjusts the output power and repetition frequency of the laser light source system according to the temperature data monitored by the temperature sensor 3 through electrical signal connection.

[0057] The higher the output power of the laser light source system, the larger the effective ablation area and the faster the ablation rate, and blood vessel damage is more likely to occur. The higher the repetition frequency, the faster the ablation speed, but the number of large particles generated during the ablation process will also be larger, and the plaque fragments or detached thrombi generated by laser ablation will block the distal microvessels, making blood vessel damage and no-reflow more likely to occur. Generally, the output power is determined by the ablation area, and the repetition frequency is determined by the type of ablation plaque and the degree of lesion.

[0058] The combination of laser output power and repetition frequency used for different ablation conditions is different. In this embodiment, taking atherosclerosis as an example, the repetition frequency is controlled to be in the low frequency range (i.e. less than or equal to 50% of the peak repetition frequency) for the ablation of soft thrombus plaques generated by atherosclerosis, thereby reducing the number of large particles generated in the blood vessels after ablation. Then, the output power of the laser is selected according to the ablation plaque area. When the ablation plaque area is greater than or equal to two-thirds of the catheter aperture, it is judged to be a large thrombus condition, at which time a high output power (i.e. greater than or equal to 75% of the output peak power) is used, and the repetition frequency is in the low frequency range to achieve the maximum effective ablation area. When the ablation plaque area is of normal size, the effective ablation requirement area is also small under this condition, so the light source output mode is adjusted to a medium-low output power (i.e. 30% to 70% of the output peak power), and the repetition frequency is in the low frequency range.

[0059] When the high-resistance lesion site such as calcified plaque is treated, high output power and high repetition frequency range (i.e. more than 50% of the peak repetition frequency) are used to ensure that the ablation site is ablated in a click manner and can pass through the lesion site in a short time, thereby avoiding the effects of heat accumulation and blood vessel damage.

[0060] After the laser ablation device is started, the output power and repetition frequency of the laser light source system are adjusted from low to high, and the ablation is started from the lowest output power and the lowest repetition frequency, and the output power is gradually increased to achieve the purpose of effective ablation. When the real-time damage of the blood vessel is collected by the temperature sensor 3 and the multi-spectral compound eye monitoring module during the ablation, the light source output module will also make corresponding adjustment, and it should be noted that the output power and the repetition frequency should be adjusted in the same direction, i.e. the output power and the repetition frequency are simultaneously reduced or increased.

[0061] The temperature of the ablation site can be obtained in real time by the temperature sensor 3, and since the common temperature of the ablation site and the surrounding tissue during the actual ablation operation is about 50℃, when the temperature of the ablation site and the surrounding tissue is 50-55℃, the output power is dynamically reduced to the next lower gear (i.e. the absolute peak power is reduced by 20%-30%), and the physiological saline injection speed is increased, and when the temperature of the ablation site and the surrounding tissue is greater than 55℃, the repetition frequency is adjusted to 0, the output of the pulsed laser is immediately stopped, and the physiological saline is injected at the maximum injection speed to reduce the temperature.

[0062] On the basis of the information obtained by the temperature sensor 3, the output power and the repetition frequency of the laser light source system are also adjusted based on the multi-spectral image, and the main technical principle is that the spectral information of the ablation site tissue is collected in real time by the compound eye multi-spectral imaging component at the ablation end, and the imaging data processing system controls the light source output parameters according to the corresponding spectral information.

[0063] In the compound eye lens used in the application, each monitoring unit can integrate 7 different waveband filters in the same area, i.e. the spectral information of 7 different spectral bands in the same area can be obtained at the same time, and the real-time spectral curve of the corresponding area can be obtained after post-processing and fitting. Since the composition of the tissue changes after the blood vessel wall is burned (such as denaturation of hemoglobin and decrease of water content), the corresponding spectral curve will deviate obviously from the spectral curve of the same area without burning phenomenon. When the deviation is within a reasonable range, the output power is dynamically reduced (i.e. the absolute peak power is reduced by 20%-30%), and the physiological saline injection speed is increased at the same time, and when the curve deviation is obviously beyond the reasonable threshold, the repetition frequency is adjusted to 0, the output of the pulsed laser is immediately stopped, and the physiological saline is injected at the maximum perfusion speed to reduce the temperature.

Claims

1. A compound eye laser ablation catheter, comprising a catheter body, the catheter body comprising a guide wire (2), a light transmission fiber layer for transmitting pulsed laser, a catheter lumen (1) for injecting normal saline arranged along the central axis of the light transmission fiber layer, and a catheter cladding (6) arranged outside the light transmission fiber layer; the guide wire (2) is arranged on the central axis of the catheter lumen (1); characterized in that: further comprising M temperature sensors (3) and an imaging module, wherein M≥2; the light transmission fiber layer comprises a plurality of light transmission fibers (4) and a heat conduction layer (5) filled between the light transmission fibers (4), the distal end of the heat conduction layer (5) is used to abut a cold surface for heat conduction; the probes of the M temperature sensors (3) are located at the ablation end of the catheter body and are uniformly arranged in the catheter lumen (1) along the circumference of the guide wire (2); the imaging module is arranged on the catheter cladding (6) and close to the ablation end of the catheter body, comprising at least two compound eye imaging assemblies (7) uniformly arranged along the circumference of the catheter cladding (6), the compound eye imaging assemblies (7) are used for real-time imaging of the ablation part and transmitting it to the outside.

2. The compound eye laser ablation catheter according to claim 1, characterized in that: the compound eye imaging assembly (7) comprises a compound eye lens arranged on the side wall of the catheter cladding (6) and a detector corresponding to the compound eye lens, the compound eye lens is a microlens array arranged along a curved surface, the microlens array comprises a plurality of microlenses arranged in a hexagonal honeycomb structure; each microlens and its six neighboring microlenses are defined as a monitoring unit, and each microlens of each monitoring unit corresponds to a different working wavelength.

3. The compound eye laser ablation catheter according to claim 1 or 2, characterized in that: the number N of the light transmission fibers (4) is calculated by the following formula:

4. The compound eye laser ablation catheter according to claim 3, characterized in that: a protective glass cover (8) is arranged at the ablation end of the light transmission fiber layer; the heat conduction layer (5) is composed of heat conduction potting glue injected into the gap between adjacent light transmission fibers (4); the temperature sensor (3) is a micro thin film temperature sensor; a plurality of the light transmission fibers (4) are arranged in concentric circles around the central axis, and the fiber filling coefficient is 75.7%, or a plurality of the light transmission fibers (4) are arranged in layers from the inside to the outside in a hexagonal shape, and the fiber filling coefficient is 90.69%.

5. A laser ablation device, characterized in that: comprising a laser light source system, an intelligent temperature control system, the compound eye laser ablation catheter of claim 1, and an imaging data processing system; the output end of the laser light source system is connected to the compound eye laser ablation catheter for providing a laser light source; the intelligent temperature control system is connected with the temperature sensor (3) and the laser light source system respectively, for dynamically adjusting the output power and repetition frequency of the laser light source system according to the temperature data monitored by the temperature sensor (3). ​ ​ ​ ​ ​ where r o is the outer radius of the light-carrying fiber layer, r i is the inner radius of the catheter lumen, r f is the radius of the light-carrying fiber, and β is the fiber fill factor. ​ ​ ​ ​ ​ ​ ​ ​ ​ The input end of the imaging data processing system is connected with the output end of the imaging module, used for receiving and processing the image formed by the imaging module, and controlling the output power and repetition frequency of the laser light source system according to the processing result, and meanwhile identifying the corresponding region.

6. The laser ablation device according to claim 5, characterized in that: The compound eye imaging assembly (7) comprises a compound eye lens arranged on the sidewall of the catheter cladding (6) and a detector, the compound eye lens is a microlens array arranged along a curved surface, and the microlens array comprises a plurality of microlenses arranged in a hexagonal honeycomb structure; Definition, each of the microlenses and the six microlenses in the neighborhood thereof is a monitoring unit, and the microlenses of each monitoring unit are respectively arranged at different working wavelengths to realize large-field multi-spectral compound eye imaging; The detector is arranged correspondingly to the compound eye lens, used for detecting a multi-spectral image, and transmitting the multi-spectral image of the ablation part to the imaging data processing system in a wireless transmission mode; The imaging data processing system performs spectral chemical analysis on the composition of the ablation part according to the multi-spectral image.

7. A control method of a laser ablation apparatus, characterized by, The method comprises the following steps: Step 1, building the laser ablation device of claim 5; Step 2, starting the laser light source system, the intelligent temperature control system and the imaging data processing system; Step 3, the laser light source system works according to the preset output power and repetition frequency, and physiological saline is injected into the catheter lumen (1) at the same time; Step 4, adjusting the output power and repetition frequency of the laser light source system and the speed of injecting physiological saline according to the data of the intelligent temperature control system and the imaging data processing system; the output power and repetition frequency are simultaneously reduced or simultaneously increased.

8. The control method of the laser ablation device according to claim 7, characterized in that: In step 1, the imaging module of the compound eye laser ablation catheter in the laser ablation device is used for acquiring a multi-spectral image; Step 4 specifically comprises: detecting the temperature of the ablation part by the temperature sensor (3), and adjusting the output power and repetition frequency of the laser light source system and the speed of injecting physiological saline by the intelligent temperature control system according to the temperature of the ablation part; The imaging data processing system fits the real-time spectral curve of the current region according to the multi-spectral image, compares it with the spectral curve of the region in the normal state, reduces the output power and repetition frequency of the laser light source system and increases the speed of injecting physiological saline when the deviation is within the set threshold, adjusts the repetition frequency to 0 when the deviation exceeds the set threshold, stops the output of the light source, and adjusts the speed of injecting physiological saline to the highest to achieve cooling.

9. The control method of a laser ablation apparatus according to claim 8, wherein In step 4, the intelligent temperature control system adjusts the output power and repetition frequency of the laser light source system according to the temperature of the ablation part, specifically: When the temperature of the ablation part and the surrounding tissue is 50-55℃, the output power is reduced to the next lower gear and the speed of injecting physiological saline is increased, and when the temperature of the ablation part and the surrounding tissue is greater than 55℃, the repetition frequency is adjusted to 0, the output of the laser light source system is stopped, and the physiological saline is injected at the maximum speed to cool down.

Images