Polypeptide synergistic composition capable of instantly and efficiently resisting and fading wrinkles, preparation method of polypeptide synergistic composition and cosmetics

Abstract

The invention relates to the field of cosmetics, in particular to a polypeptide synergistic composition capable of instantly and efficiently resisting and fading wrinkles, a preparation method of the polypeptide synergistic composition and cosmetics. The composition is prepared from the following components in percentage by weight: 0.2 to 0.41 percent of first component, 5.5 to 12 percent of second component and the balance of water, the first component is prepared from acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide; the second component is prepared from a radix sophorae flavescentis extract, a tribulus terrestris fruit extract and a dogwood fruit extract. The three polypeptides form nervous excitation pathway full-chain type inhibition, muscle contraction inhibition is enhanced, and the instant and efficient anti-wrinkle effect is achieved. By synergistically compounding with the dogwood fruit extract, the tribulus terrestris fruit extract and the radix sophorae flavescentis extract, the better instant anti-wrinkle and wrinkle-fading effects are achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular, to an instant and efficient anti-wrinkle and fine line polypeptide synergistic composition, a preparation method thereof and a cosmetic. BACKGROUND

[0002] At present, anti-wrinkle compositions and anti-wrinkle and fine line products on the market are developed one after another, but some products have the problems of no obvious actual effect, long effect time and strong irritation, and cannot meet the needs of consumers.

[0003] For example, the anti-aging products on the market commonly use acetyl hexapeptide-8, which has the problems of no obvious anti-wrinkle effect and strong irritation. SUMMARY

[0004] The purpose of the embodiments of the present application is to provide an instant and efficient anti-wrinkle and fine line polypeptide synergistic composition, a preparation method thereof and a cosmetic.

[0005] In a first aspect, the present application provides an instant and efficient anti-wrinkle and fine line polypeptide synergistic composition, which is composed of 0.2wt%-0.41wt% of a first component, 5.5wt%-12wt% of a second component and the balance of water.

[0006] The first component is composed of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide.

[0007] The second component is composed of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni.

[0008] In the technical scheme, the acetyl octapeptide-3 can act on the presynaptic membrane, compete with SNAP-25 for the binding site, inhibit the formation of SNARE complex, and inhibit the release of catecholamine; the arginine / lysine polypeptide can inhibit sodium ion influx, block the current conduction of neuromuscular, and also inhibit the release of metalloproteinase 1; the dipeptide diaminobutyryl benzyl amide diacetate can act on the postsynaptic membrane, antagonize acetylcholine receptor, thereby preventing acetylcholine from combining with the receptor, blocking the sodium ion channel, and additionally having the effect of promoting PLOD3 to synthesize collagen fibers of better quality. The three polypeptides of the composition form a whole-chain inhibition of the neurotransmitter release-receptor binding-electrical signal conduction nerve excitation pathway, thereby enhancing the inhibition of muscle contraction and achieving an instant and efficient anti-wrinkle effect. The polypeptide component is synergistically compounded with the extract of fructus corni, the extract of fructus tribuli, and the extract of radix sophorae flavescens, thereby endowing the composition with better free radical scavenging, anti-aging and antioxidant, and skin soothing effects, and the synergistic effect of long-acting and continuous wrinkle lightening can be achieved, the formation of collagen and elastin can be promoted, the skin elasticity can be increased, and the long-acting anti-wrinkle and wrinkle lightening effect can be improved. The above-mentioned raw materials in the above-mentioned ratio range can effectively improve the instant and efficient anti-wrinkle and wrinkle lightening effect of the composition.

[0009] Further, in some embodiments of the present application, the polypeptide synergistic composition does not contain acetyl hexapeptide-8, and can achieve good anti-wrinkle and wrinkle lightening effect while having good soothing effect.

[0010] In other embodiments of the present application, the composition is composed of 0.32wt%-0.41wt% of the first component, 6wt%-9wt% of the second component, and the balance of water.

[0011] In other embodiments of the present application, in the first component, the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate, and arginine / lysine polypeptide is (0.1-0.3)wt%:(0.1-0.3)wt%:(0.01-0.03)wt%.

[0012] In other embodiments of the present application, in the second component, the ratio of the extract of radix sophorae flavescens, the extract of fructus tribuli, and the extract of fructus corni is (1-5)wt%:(1.5-5)wt%:(1-4)wt%.

[0013] In other embodiments of the present application, in the first component, the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate, and arginine / lysine polypeptide is (0.2-0.3)wt%:(0.2-0.3)wt%:(0.01-0.02)wt%.

[0014] In other embodiments of the present application, the ratio of Sophora flavescens extract, Tribulus terrestris fruit extract and Fructus Corni extract in the second component is (2.5-3) wt%:(2-4) wt%:(2-4) wt%.

[0015] In a second aspect, the present application provides a preparation method of the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition, comprising:

[0016] The raw materials in the first component are dissolved in water and mixed uniformly to obtain a first solution.

[0017] Sophora flavescens extract, Tribulus terrestris fruit extract and Fructus Corni extract are added to the first solution and mixed uniformly.

[0018] In other embodiments of the present application, the raw materials in the first component are dissolved in water, comprising:

[0019] The acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide are mixed and stirred until completely dissolved.

[0020] In other embodiments of the present application, the stirring speed is 300 rpm / min-600 rpm / min.

[0021] In a third aspect, the present application provides a cosmetic product comprising the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition provided by any one of the preceding first aspect; or the cosmetic product comprises the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition prepared by the preparation method of any one of the preceding second aspect.

[0022] In other embodiments of the present application, the addition amount of the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition in the cosmetic product is 1 wt%-5 wt%. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be described clearly and completely below. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments.

[0024] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but only represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present application.

[0025] The embodiment of the present application provides a polypeptide synergistic composition for instant and efficient anti-wrinkle and wrinkle lightening, which is composed of 0.2wt%-0.41wt% of a first component, 5.5wt%-12wt% of a second component and the balance of water;

[0026] The first component is composed of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide;

[0027] The second component is composed of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni extract.

[0028] In the technical scheme, acetyl octapeptide-3 can act on the presynaptic membrane, compete with SNAP-25 for the binding site, inhibit the formation of SNARE complex, and inhibit the release of catecholamine; arginine / lysine polypeptide can inhibit sodium ion influx, block nerve-muscle current conduction, and also inhibit the release of metalloproteinase 1; dipeptide diaminobutyryl benzyl amide diacetate can act on the postsynaptic membrane, antagonize acetylcholine receptors, thereby preventing acetylcholine from binding to the receptors, blocking the sodium ion channel, and additionally having the effect of promoting PLOD3 to synthesize collagen fibers of better quality. The three polypeptides of the composition form a whole-chain inhibition of the neurotransmitter release-receptor binding-electrical signal conduction nerve excitation pathway, thereby enhancing the inhibition of muscle contraction and achieving the effect of instant and efficient anti-wrinkle. The polypeptide components are synergistically compounded with Fructus Corni extract, Tribulus terrestris fruit extract and Sophora flavescens root extract, so that the composition has better effects of free radical scavenging, anti-aging and anti-oxidation, and skin soothing, can realize the synergistic effect of long-acting and continuous wrinkle lightening, can promote the formation of collagen and elastin, increase skin elasticity, and improve the long-acting anti-wrinkle and wrinkle lightening effect. The above-mentioned raw materials in the above-mentioned ratio range can effectively improve the instant and efficient anti-wrinkle and wrinkle lightening effect of the composition.

[0029] Exemplarily, in some embodiments of the present application, the composition is composed of: 0.2wt%, 0.21wt%, 0.22wt%, 0.23wt%, 0.24wt%, 0.25wt%, 0.26wt%, 0.27wt%, 0.28wt%, 0.29wt%, 0.30wt%, 0.31wt%, 0.32wt%, 0.33wt%, 0.34wt%, 0.35wt%, 0.36wt%, 0.37wt%, 0.38wt%, 0.39wt%, 0.40wt%, 0.41wt%, or any range between any two of the aforementioned values, of the first component; 5.5wt%, 5.6wt%, 6.0wt%, 6.5wt%, 7.0wt%, 7.5wt%, 8.0wt%, 8.5wt%, 8.5wt%, 9.0wt%, 9.5wt%, 10.0wt%, 11wt%, 12wt%, or any range between any two of the aforementioned values, of the second component, and the balance of water.

[0030] Further optionally, in some embodiments of the present application, the composition is composed of: 0.32wt% to 0.41wt% of the first component, 6wt% to 9wt% of the second component, and the balance of water.

[0031] The extract of Cornus officinalis fruit can inhibit the expression of pro-inflammatory cytokines IL-6 and TNF-α, reduce the occurrence of inflammation, and promote the expression of collagen type III and elastin to enhance skin elasticity. In the above technical solution, the extract of Cornus officinalis fruit is compounded with other ingredients such as acetyl octapeptide-3, dipeptide diaminobutyryl glycine amide diacetate, and arginine / lysine polypeptide, so as to improve the anti-wrinkle and fine line effect of the composition.

[0032] The extract of Tribulus terrestris fruit can inhibit the activity of tyrosinase, has whitening and moisturizing effects. The extract of Sophora flavescens root can inhibit the release of inflammatory mediators by immune cells, reduce skin inflammation, inhibit the growth and reproduction of Propionibacterium acnes, maintain skin ecological balance, and promote the generation of collagen and elastin, and has anti-aging effect. In the above technical solution, the extract of Tribulus terrestris fruit is compounded with other ingredients such as acetyl octapeptide-3, dipeptide diaminobutyryl glycine amide diacetate, and arginine / lysine polypeptide, so as to improve the anti-wrinkle and fine line effect of the composition.

[0033] The extract of Sophora flavescens root can inhibit the activity of collagenase, reduce the release of allergic mediators, promote the repair of damaged cells, and has the effects of anti-aging, anti-allergy, and maintaining the healthy state of the skin. In the above technical solution, the extract of Tribulus terrestris fruit is compounded with other ingredients such as acetyl octapeptide-3, dipeptide diaminobutyryl glycine amide diacetate, and arginine / lysine polypeptide, so as to improve the anti-wrinkle and fine line effect of the composition.

[0034] Further, in some embodiments of the present application, the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide in the first component is (0.1-0.3)wt%:(0.1-0.3)wt%:(0.01-0.03)wt%.

[0035] Illustratively, in some embodiments of the present application, the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide in the first component is (0.1, 0.15, 0.18, 0.2, 0.22, 0.25, 0.28, 0.3 or a range between any two of the aforementioned values)wt%:(0.1, 0.15, 0.18, 0.2, 0.22, 0.25, 0.28, 0.3 or a range between any two of the aforementioned values)wt%:(0.01, 0.015, 0.02, 0.025, 0.03 or a range between any two of the aforementioned values)wt%.

[0036] Further, in some embodiments of the present application, the ratio of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni extract in the second component is (1-5)wt%:(1.5-5)wt%:(1-4)wt%.

[0037] Illustratively, in some embodiments of the present application, the ratio of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni extract in the second component is (1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 or a range between any two of the aforementioned values)wt%:(1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 or a range between any two of the aforementioned values)wt%:(1, 1.5, 2, 2.5, 3, 3.5, 4 or a range between any two of the aforementioned values)wt%.

[0038] Further optionally, in some embodiments of the present application, the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide in the first component is (0.2-0.3)wt%:(0.2-0.3)wt%:(0.01-0.02)wt%.

[0039] Further optionally, in some embodiments of the present application, the ratio of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni extract in the second component is (2.5-3)wt%:(2-4)wt%:(2-4)wt%.

[0040] Some embodiments of the present application provide a preparation method of a polypeptide synergistic composition for instant and efficient anti-wrinkle and fine line reduction, comprising:

[0041] The first component is dissolved in water to obtain a first solution.

[0042] The first solution is mixed with the extract of Sophora flavescens, the extract of Tribulus terrestris and the extract of Fructus Corni.

[0043] Further, in some embodiments of the present application, the first component is dissolved in water, including:

[0044] The acetyl octapeptide-3, dipeptide diaminobutyryl glycine benzyl amide diacetate and arginine / lysine polypeptide are mixed and stirred until completely dissolved.

[0045] Further, in some embodiments of the present application, the stirring speed is 300 rpm / min to 600 rpm / min.

[0046] Exemplarily, in some embodiments of the present application, the stirring speed is 300 rpm / min, 310 rpm / min, 320 rpm / min, 330 rpm / min, 340 rpm / min, 350 rpm / min, 360 rpm / min, 370 rpm / min, 380 rpm / min, 390 rpm / min, 400 rpm / min, 410 rpm / min, 420 rpm / min, 430 rpm / min, 450 rpm / min, 480 rpm / min, 500 rpm / min, 530 rpm / min, 550 rpm / min, 580 rpm / min, 600 rpm / min or a range between any two of the foregoing values.

[0047] In the above technical solution, the three polypeptides of the composition form a neurotransmitter pathway full-chain inhibition of transmitter release-receptor binding-electrical signal conduction, thereby enhancing the inhibition of muscle contraction and achieving an instant and efficient anti-wrinkle effect. The polypeptide component is synergistically compounded with the three soothing and anti-aging components of the extract of Fructus Corni, the extract of Tribulus terrestris and the extract of Sophora flavescens, which promotes the formation of collagen and elastin, restores the tight and elastic state of the skin, and obtains a composition that instantaneously inhibits wrinkles, effectively and continuously lightens wrinkles, delays skin aging, antioxidant, soothes the skin and maintains the skin barrier.

[0048] Some embodiments of the present application provide a cosmetic product comprising the instant and efficient anti-wrinkle and wrinkle-lightening polypeptide synergistic composition provided by any of the preceding embodiments.

[0049] Some embodiments of the present application provide a cosmetic product comprising the instant and efficient anti-wrinkle and wrinkle-lightening polypeptide synergistic composition prepared by the preparation method of the instant and efficient anti-wrinkle and wrinkle-lightening polypeptide synergistic composition provided by any of the preceding embodiments.

[0050] Further, in some embodiments of the present application, the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition is added to the cosmetic product in an amount of 1 wt% to 5 wt%.

[0051] Illustratively, in some embodiments of the present application, the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition is added to the cosmetic product in an amount of 1 wt%, 1.5 wt%, 2 wt%, 2.5 wt%, 3 wt%, 3.5 wt%, 4 wt%, 4.5 wt%, 4.6 wt%, 4.7 wt%, 4.8 wt%, 5 wt%, or a range between any two of the foregoing values.

[0052] In some embodiments of the present application, the instant high-efficiency anti-wrinkle and fine-line polypeptide synergistic composition described above can be compounded with common cosmetic carriers (e.g., emulsifiers, thickening agents, etc.) in the art to form a cosmetic product; the dosage form of the cosmetic product can be selected from common emulsions, creams, serums, etc.

[0053] Further optionally, in some embodiments of the present application, when the dosage form of the cosmetic product is selected to be a serum, the serum described above can include, in terms of mass percentage: 0.1%-0.15% carbomer, 1%-5% 1,3 butanediol, 0.1%-0.5% allantoin, 1%-5% glycerol polyether-26, 0.05%-0.15% aminomethylpropanol, 1%-5% beta-glucan, 0.01%-0.05% ethylhexylglycerin, 0.01%-0.1% disodium EDTA, 0.01%-0.05% 1,2-hexanediol, 0.03%-0.08% octanoyl hydroxamic acid, 1%-5% of the instant high-efficiency anti-wrinkle and fine-line composition described above, 0.001%-0.01% fragrance; and the balance being water.

[0054] The features and performance of the present application are further described in detail below in connection with the following examples:

[0055] Examples 1-10 and Comparative Examples 1-9

[0056] A composition is provided, the compositions of each of the examples and comparative examples are shown in Table 1 below. Raw material sources: Acetyl octapeptide-3 is from Zhejiang Pailai Biological Co., Ltd.; Acetyl hexapeptide-8, dipeptide diaminobutyryl benzyl amide diacetate, arginine / lysine polypeptide are from Chengdu Shengnuo Biological Technology Co., Ltd.; Sophora flavescens root extract is from Beijing Dongfangmiosen Biological Technology Co., Ltd.; Tribulus terrestris fruit extract is from Beijing Dongfangmiosen Biological Technology Co., Ltd.; Fructus corni fruit extract is from Beijing Dongfangmiosen Biological Technology Co., Ltd.; Octanoyl glycol is from Deqing Fragrance & Flavor (Nantong) Co., Ltd.

[0057] Table 1 (wt%)

[0058]

[0059]

[0060] The preparation method is as follows:

[0061] (1) According to the proportion in the above table, each raw material of the first component is dissolved in water, and the mixture is stirred at 20°C and 200 rpm / min until completely uniform to obtain a first solution;

[0062] (2) While stirring at 20°C and 500 rpm / min, octanol is added to the first solution, and the mixture is completely mixed until a colorless transparent solution is obtained to obtain a second solution;

[0063] (3) At 20°C and 500 rpm / min, each raw material of the second component is added to the second solution, and the mixture is completely mixed.

[0064] The properties of the composition samples obtained in each example and comparative example are tested:

[0065] 1. Anti-wrinkle test

[0066] The test method is as follows:

[0067] Caenorhabditis elegans is widely used in the study of body aging due to its small size, short life cycle, rapid reproduction, clear genetic background, easy cultivation and observation, and high homology with human genes. The anti-wrinkle test of the nematode—excitement model detects the ability of neuropeptides to block nerve impulses between nerves and muscles. By detecting the head swing frequency of the nematode, the immediate anti-wrinkle and fine line effect of neurotransmitter inhibitory peptides can be evaluated, so as to evaluate the immediate anti-wrinkle and fine line efficacy of each composition sample.

[0068] The specific test method is as follows:

[0069] Synchronized L4 nematodes were picked into the blank group and experimental group medium, and after 3 days of drug intervention, the number of head swings of each nematode within 30s was observed and recorded.

[0070] Blank control group: Take 95 μL of E. coli OP50 bacterial solution and 5 μL of M9 mixture, and use a pipette to gently hit 100-120 μL of bacterial solution on the center of each NGM plate.

[0071] Sample group: Take 95 μL of E. coli OP50 bacterial solution and 5 μL of sample group sample mixture (sample volume fraction is 5%), and use a pipette to gently hit 100-120 μL of bacterial solution on the center of each NGM plate. Store at 4°C for standby.

[0072] The inhibition rate of head shaking of nematodes = (blank control group - sample group) / blank control group * 100%. The higher the inhibition rate of head shaking of nematodes, the stronger the instant anti-wrinkle and fine line effect of the sample.

[0073] The number of * indicates the degree of significance; the more the number of *, the more significant the anti-wrinkle and fine line effect.

[0074] The test results are shown in Table 2.

[0075] Table 2

[0076]

[0077]

[0078] From the data in Table 2 above, it can be seen that:

[0079] The inhibition rate of head shaking of nematodes of the sample of each embodiment is higher than that of each comparative example. Therefore, it can be shown that the scheme of the embodiments of the application can effectively improve the anti-wrinkle and fine line effect.

[0080] Further, when acetyl hexapeptide-8 is used to replace acetyl octapeptide-3 in the application, the inhibition rate of head shaking of nematodes of comparative example 1 decreases significantly, which shows that the components in the composition of the application cannot be replaced arbitrarily; the scheme after replacement cannot achieve the technical effect of the application.

[0081] Further, compared with the scheme of example 2, the anti-wrinkle effect of the composition of the embodiments of the application is higher than that of each single component, which shows that the scheme of the embodiments of the application has a synergistic effect of each component.

[0082] Further, compared with comparative examples 2-5, it can be seen that the anti-wrinkle effect of the scheme of comparative example 1 using acetyl hexapeptide-8, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide combination is lower than that of each single component of comparative examples 2-5, which shows that even if the target points of each single component are similar, there is still an antagonistic phenomenon. Further, it shows that the ratio of the application cannot be arbitrarily adjusted.

[0083] When the composition is composed of 0.32wt%-0.41wt% of the first component, 6wt%-9wt% of the second component and the balance of water, the inhibition rate of head shaking of nematodes increases, which shows that there is a better anti-wrinkle and fine line effect in this range.

[0084] Application Example 1

[0085] The instant high-efficiency anti-wrinkle and fine line polypeptide synergistic composition prepared by the aforementioned example 1 is used to prepare an essence.

[0086] The formula of the essence is shown in Table 3:

[0087] Table 3

[0088]

[0089]

[0090] The preparation method of the essence is as follows:

[0091] 1) Dissolve EDTA disodium in water completely, add carbomer, glycerol polyether-26, 1,3-butanediol, allantoin, and homogenize at low speed (~3000 r / min) for 15 min after 80℃ water bath preservation;

[0092] 2) Stir at 400 r / min to cool to about 50℃, then add aminomethylpropanol, β-glucan, octanoyl hydroxamic acid, ethylhexyl glycerin, 1,2-hexanediol, each raw material of Example 3, and essence in sequence, stir uniformly, and cool to room temperature.

[0093] The sample provided in the application example 1 above was subjected to human anti-wrinkle efficacy evaluation: 20 volunteers aged over 40 years old with obvious nasolabial folds and crow's feet were selected to use the sample for evaluation.

[0094] (1) Three-dimensional image collection was performed on the nasolabial fold and crow's feet part before and after using the essence for 30 min, and the changes in the area and volume of the nasolabial fold wrinkle and the number and area of the crow's feet wrinkle were analyzed; the average value was used for evaluating the actual effect of each sample. The test results are shown in Table 4.

[0095] Table 4: Three-dimensional image collection and analysis results

[0096]

[0097]

[0098] As can be seen from the test data measured by the above test method, the essence prepared by the application example can effectively reduce the area of the nasolabial fold wrinkle, the volume of the nasolabial fold wrinkle, the number of the crow's feet wrinkle, and the area of the crow's feet wrinkle; thus, it is illustrated that the essence of the application has an instant and efficient anti-wrinkle effect.

[0099] The above only describes the preferred embodiments of the application and is not intended to limit the application. For those skilled in the art, the application can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the application shall be included in the protection scope of the application.

Claims

1. A polypeptide synergistic composition for instant high efficiency anti-wrinkle and fine line reduction, characterized in that, The composition is composed of 0.2wt%-0.41wt% first component, 5.5wt%-12wt% second component and the rest water; The first component is composed of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide; The second component is composed of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni. 2.The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of claim 1, wherein the composition is composed of 0.32wt%-0.41wt% first component, 6wt%-9wt% second component and the rest water. 3.The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of claim 1 or 2, wherein the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide in the first component is (0.1-0.3)wt%:(0.1-0.3)wt%:(0.01-0.03)wt%. 4.The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of claim 1 or 2, wherein the ratio of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni in the second component is (1-5)wt%:(1.5-5)wt%:(1-4)wt%. 5.The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of claim 1 or 2, wherein the ratio of acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide in the first component is (0.2-0.3)wt%:(0.2-0.3)wt%:(0.01-0.02)wt%. 6.The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of claim 1 or 2, wherein the ratio of Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni in the second component is (2.5-3)wt%:(2-4)wt%:(2-4)wt%. The method comprises: dissolving each raw material in the first component in water and mixing uniformly to obtain a first solution; adding Sophora flavescens root extract, Tribulus terrestris fruit extract and Fructus Corni to the first solution and mixing uniformly. The method comprises: dissolving each raw material in the first component in water and mixing uniformly to obtain a first solution; 7. A method of preparing the instant synergistic polypeptide composition for anti-wrinkle and fine line treatment according to any one of claims 1 to 6, characterized in that, mixing and stirring acetyl octapeptide-3, dipeptide diaminobutyryl benzyl amide diacetate and arginine / lysine polypeptide until completely dissolved. The stirring speed is 300rpm / min-600rpm / min. The instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition of any one of claims 1-6; or the instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition prepared by the method of any one of claims 7-9.

8. The method of claim 7, wherein the polypeptide synergistic composition is prepared by the steps of: a) mixing the polypeptide and the active ingredient; b) adding the mixture to a carrier; and c) mixing the mixture and the carrier. Optionally, the instant high-efficiency anti-wrinkle and fine wrinkle polypeptide synergistic composition is added to the cosmetic in an amount of 1wt%-5wt%. ​ ​ 9. The method of claim 8, wherein the polypeptide synergistic composition is prepared by the steps of: a) mixing the polypeptide and the active ingredient; b) adding the mixture to a carrier; and c) mixing the mixture and the carrier. ​ ​ 10. A cosmetic product, characterized by, ​ ​

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