A mild moisturizing skin care composition and its use

Abstract

The application discloses a kind of mild moisturizing skin care compositions and its application, belong to cosmetic technical field;The skin care composition provided by the application includes emulsifier, auxiliary agent, oil and humectant;The emulsifier includes peanut alcohol glucoside and polyglycerol fatty acid ester;The auxiliary agent includes ceramide EOP, stearic acid and phytosterol;The oil includes first oil, second oil and third oil, the first oil includes liquid oil, the second oil includes natural semi-solid fat with melting point 25-52 DEG C, and the third oil includes at least one of spermocetyl alcohol and behenyl alcohol;The humectant includes polyhydric alcohol.The skin care composition obtained by the application can quickly relieve skin dryness and has long-term moisturizing effect, and can effectively improve skin barrier ability by selecting specific components and mutual compounding;In addition, the obtained skin care product is mild, and has excellent storage stability and use experience.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, and in particular relates to a mild moisturizing skin care composition and its application. Background Technology

[0002] Children with sensitive skin, such as those with atopic dermatitis, have damaged skin barriers, increased transepidermal water loss, and extremely dry and sensitive skin, requiring high levels of product safety. The moisturizing effect of skincare products is positively correlated with the type and amount of moisturizers, functional moisturizers, and the barrier properties of the system. Different moisturizing combinations have different hygroscopic capacities; the greater the hygroscopic capacity, the better the moisturizing effect. Functional moisturizers can promote the production of natural moisturizing factors and enhance the expression of aquaporins, thus improving moisturizing effects. The barrier effect of the system can effectively form a sealing film on the skin surface, significantly reducing the rate of water loss from the skin surface to the environment. Building a strong barrier system is key to "locking in" moisture and maximizing moisturizing efficacy. The barrier capacity of the system is closely related to different oils, emulsifiers, and their combinations.

[0003] In order to improve the moisturizing effect of skin care products, existing technologies often increase the types and amounts of moisturizers in the formula design, add functional moisturizers, etc., while ignoring the product's barrier function design. However, this often leads to an increase in product irritation, which is not conducive to the use of people with sensitive skin, and is especially unsuitable for the delicate skin of babies. Summary of the Invention

[0004] The purpose of this invention is to overcome the shortcomings of the prior art by cleverly combining emulsifiers, auxiliaries, oils and moisturizers through E (Emulsification System), L (Lipid Design), and M (Moisturizing System) formulation design technology. This provides a gentle moisturizing skincare composition and its application that not only has excellent rapid relief of dry skin and long-lasting moisturizing effect and long-lasting skin barrier enhancement effect, but also has excellent gentleness, product storage stability and good user experience.

[0005] To achieve the above objectives, in a first aspect, the present invention provides a mild moisturizing skincare composition, the skincare composition comprising an emulsifier, an auxiliary agent, an oil, and a moisturizer;

[0006] The emulsifiers include arachidonic acid glucoside and polyglycerol fatty acid esters;

[0007] The adjuvants include ceramide EOP, stearic acid, and phytosterols;

[0008] The grease includes a first grease, a second grease, and a third grease. The first grease includes a liquid grease, the second grease includes a natural semi-solid grease with a melting point of 25-52°C, and the third grease includes at least one of cetearyl alcohol and behenyl alcohol.

[0009] The moisturizer includes polyols.

[0010] This invention has discovered that by selecting the emulsifier system, auxiliary agent system, oil system, and moisturizer of this invention, the systems are compounded together, and the components within the systems also have good synergistic effects. As a result, skin care products obtained using the skin care composition of this invention have excellent rapid relief of dry skin and long-lasting moisturizing effects, and can effectively improve the skin barrier function. In addition, the obtained skin care products are gentle and have excellent storage stability, and can be effectively applied to sensitive skin and infant skin, with an excellent user experience.

[0011] Specifically, the emulsifiers selected in this invention include arachidonic acid glucoside and polyglycerol fatty acid esters. Based on the assembly behavior of the emulsifier molecular interface, these two compounds can be embedded and arranged at the oil-water interface after compounding, promoting the cross-linking of the emulsifier layer, strengthening the interfacial film strength and thickness of the emulsion system, thereby improving the barrier effect. This not only increases skin moisture content but also optimizes skin barrier function and enhances product stability. The adjuvant combination in this invention can further strengthen the interfacial film formed by the emulsifier and, together with the emulsifier and oil, form a skin-lipid-like layered structure, enhancing the physical barrier function of the interfacial film, further improving its occlusive properties, and thus better improving moisturizing and skin barrier function. The oil can better form an internal phase with moderate softness and better compatibility with the emulsifier on the basis of the interfacial film formed by the emulsifier, strengthening the interfacial film strength and improving the stability and occlusive properties of the film layer during skin contact and application. The selection of moisturizers can provide direct moisturizing effects in combination with emulsifiers, adjuvants, and oils. Furthermore, when the above combination is applied to subsequent skincare products, it can enhance the excellent moisturizing effect of the skincare products while also providing good application and product stability.

[0012] As a preferred embodiment of the skin care composition of the present invention, the skin care composition comprises the following components in parts by weight: 1-9 parts emulsifier, 0.03-0.5 parts auxiliary agent, 3-50 parts oil, and 1-5 parts moisturizer.

[0013] As a preferred embodiment of the skin care composition of the present invention, the skin care composition comprises the following components in parts by weight: 3-6 parts emulsifier, 0.1-0.2 parts auxiliary agent, 10-18 parts oil, and 1-4 parts moisturizer.

[0014] This invention has discovered that the mass fractions of emulsifiers, auxiliaries, oils, and moisturizers in a skincare composition affect the interactions between components. When the mass fractions of the components are further selected within the aforementioned range, the emulsifier can form an interfacial film more quickly and effectively; the auxiliaries can better enhance the stability and strength of the interfacial film; and the oils, in combination with the emulsifiers and auxiliaries, can form an internal phase with moderate softness and better compatibility with the emulsifier, strengthening the interfacial film, improving the stability and good occlusive properties of the film during skin contact and application, helping the moisturizer to function effectively with a smaller amount, and reducing the loss of moisture from the skin itself. In other words, when the mass fractions of emulsifiers, auxiliaries, oils, and moisturizers in the skincare composition are further selected within the aforementioned range, the resulting skincare composition, when applied to skincare products, exhibits excellent rapid relief of dry skin and long-lasting moisturizing effects, while also effectively enhancing the skin barrier function and maintaining good storage stability and gentleness of the product.

[0015] In a preferred embodiment of the skincare composition of the present invention, the oil has a mass percentage of 32-83% based on the total mass of the skincare composition.

[0016] For example, the percentage of the oil by mass, based on the total mass of the skin care composition, can be any point value or any two-point range between 32% and 83%, such as 32%, 35%, 40%, 42%, 45%, 50%, 52%, 54%, 56%, 58%, 60%, 62%, 64%, 66%, 68%, 70%, 72%, 75%, 80%, 83%, etc.

[0017] Preferably, the oil comprises 64-70% by weight of the total weight of the skincare composition.

[0018] More preferably, the oil comprises 64-66% by weight of the total weight of the skincare composition.

[0019] This invention has found that the mass percentage of oil in a skincare composition not only affects the formation of the oil film, but also the strength of the interfacial film formed by the emulsifier, and its interaction with the moisturizer. When the mass percentage of oil in the skincare composition is further selected within the above range, the skincare product prepared subsequently has better occlusion effect, better moisturizing effect, and can better improve the skin barrier function and product stability.

[0020] In a preferred embodiment of the skincare composition of the present invention, the mass percentage of the adjuvant is 0.05-5.3% based on the total mass of the skincare composition.

[0021] For example, the mass percentage of the adjuvant, based on the total mass of the skincare composition, can be any point value or any two-point range between 0.05% and 5.3%, such as 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.5%, 0.8%, 1.0%, 1.2%, 1.3%, 1.4%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.3%, etc.

[0022] Preferably, the mass percentage of the adjuvant is 0.4-1.4% based on the total mass of the skin care composition.

[0023] More preferably, the mass percentage of the adjuvant is 0.7-0.8% based on the total mass of the skin care composition.

[0024] This invention has found that by further selecting the mass percentage of the additives within the above-mentioned range, the stability of the interfacial film formed by the emulsifier can be better improved, the product's sealing and stability can be enhanced, thereby improving the product's moisturizing performance and skin barrier function. Furthermore, the additives within the above-mentioned range can make the product have excellent gentleness.

[0025] In a preferred embodiment of the skin care composition of the present invention, the mass ratio of the emulsifier to the oil is 1:(3-10).

[0026] For example, the mass ratio of the emulsifier to the oil can be any point value or any two points between 1:(3-10), such as 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, etc.

[0027] Preferably, the mass ratio of the emulsifier to the oil is 1:(3-8).

[0028] More preferably, the mass ratio of the emulsifier to the oil is 1:(3-5.56).

[0029] More preferably, the mass ratio of the emulsifier to the oil is 1:(3.2-3.3).

[0030] This invention has found that the mass ratio of emulsifier to oil affects the product's moisturizing effect on the skin and the product's stability, as well as its gentleness. When the mass ratio of emulsifier to oil is further selected within the above range, the overall performance of the resulting product is better.

[0031] In a preferred embodiment of the skin care composition of the present invention, the mass ratio of arachidonic acid glucoside to polyglycerol fatty acid ester in the emulsifier is (2-6):(0.01-1.5).

[0032] For example, the mass ratio of arachidonic acid glucoside to polyglycerol fatty acid ester in the emulsifier can be any point value or any two points within the range of (2-6):(0.01-1.5), such as 2:0.01, 2:0.1, 2:0.3, 2:0.5, 2:0.8, 2:1, 2:1.2, 2:1.5, 4:0.01, 4:0.1, 4:0.3, 4:0.5, 4:0.8, 4:1, 4:1.2, 4:1.5, 6:0.01, 6:0.1, 6:0.3, 6:0.5, 6:0.8, 6:1, 6:1.2, 6:1.5, etc.

[0033] This invention has found that by further selecting the mass ratio of arachidonic acid glucoside and polyglycerol fatty acid ester in the emulsifier to be within the above-mentioned range, the overall performance of the obtained product is better.

[0034] Preferably, in the emulsifier, the mass ratio of arachidonic acid glucoside to polyglycerol fatty acid ester is (3-4):(0.8-1).

[0035] As a preferred embodiment of the skin care composition of the present invention, the mass ratio of ceramide EOP, stearic acid and phytosterol in the adjuvant is ceramide EOP: stearic acid: phytosterol = 3:(0.5-1.5):(0.5-1.5).

[0036] For example, in the adjuvant, the mass ratio of ceramide EOP, stearic acid and phytosterol can be any point value or any two points within the range of ceramide EOP: stearic acid: phytosterol = 3:(0.5-1.5):(0.5-1.5), such as 3:0.5:0.5, 3:0.5:1, 3:0.5:1.5, 3:1:0.5, 3:1:1, 3:1:1.5, 3:1.5:0.5, 3:1.5:1, 3:1.5:1.5, etc.

[0037] This invention has found that, among the additives, the long-chain saturated fatty acids of ceramide EOP can promote tight molecular arrangement and form a rigid interfacial film; the carboxylic acid group of stearic acid can form hydrogen bonds with the aqueous phase, stabilizing the interfacial film; and the phytosterol structure can effectively anchor at the oil-water interface, reducing the fluidity of the interfacial film. When the three are combined in the above-mentioned mass ratio range, the resulting interfacial film has better stability and higher strength. This results in skincare products that are subsequently prepared with better rapid relief of dry skin and long-lasting moisturizing effects, better storage stability, and a better ability to enhance the skin barrier, while also being gentler.

[0038] Preferably, in the adjuvant, the mass ratio of ceramide EOP, stearic acid and phytosterol is ceramide EOP: stearic acid: phytosterol = 3:(0.8-1.2):(0.8-1.2).

[0039] As a preferred embodiment of the skin care composition of the present invention, the polyglycerol fatty acid ester includes at least one of polyglycerol-3 diisostearate, polyglycerol-4 isostearate, and polyglycerol-6 distearate.

[0040] Preferably, the polyglycerol fatty acid ester is polyglycerol-6 distearate.

[0041] This invention has found that the type of polyglycerol fatty acid ester, mainly the difference in degree of polymerization, affects its HLB value and its interaction with arachidonic acid glucoside. When polyglycerol fatty acid esters are further selected to be of the above type, they can better form an interfacial film and emulsify more oils, thereby improving the product's moisturizing properties, stability, and mildness.

[0042] As a preferred embodiment of the skin care composition of the present invention, the phytosterols include at least one of β-sitosterol, brassica campestris sterols, and phytosterol macadamia oleate.

[0043] Preferably, the phytosterols include brassica campestris sterols.

[0044] This invention has found that the type of phytosterol affects its interaction with ceramide EOP and stearic acid, thereby affecting the effect of adjuvants on emulsifiers and oils. When phytosterols are further selected to be of the above-mentioned types, they can help emulsifiers emulsify more oils and better improve the stability and strength of the interfacial film after emulsification, thereby improving the moisturizing, stability and mildness of the product.

[0045] As a preferred embodiment of the skincare composition of the present invention, the liquid oil includes plant-based liquid oil and synthetic liquid oil.

[0046] As a preferred embodiment of the skin care composition of the present invention, the plant-based liquid oil includes at least one of perilla seed oil, meadowfoam seed oil, sunflower seed oil, milk thistle seed oil, sea buckthorn fruit oil, borage oil, rice bran oil, and squalane.

[0047] As a preferred embodiment of the skin care composition of the present invention, the synthetic liquid oil includes at least one of caprylic / capric triglyceride, polydimethylsiloxane, triglyceride (ethylhexanoate), and pentaerythritol tetra(ethylhexanoate).

[0048] As a preferred embodiment of the skin care composition of the present invention, the natural semi-solid lipid with a melting point of 25-52°C includes at least one of shea butter, cocoa seed butter, jojoba esters, and muruman seed butter.

[0049] This invention has found that by selecting the above-mentioned types of plant-based liquid oils, synthetic liquid oils, and natural semi-solid oils, they can better cooperate with the third oil, improving the product's sealing performance while also exhibiting excellent formulation stability, avoiding the problem of coarsening at low temperatures, and providing a good application feel.

[0050] In a preferred embodiment of the skincare composition of the present invention, the mass percentage of oleic acid in the plant-based liquid oil is ≤20%.

[0051] For example, the mass percentage of oleic acid in the first oil can be any point value or any two points within a range of ≤20%, such as 1%, 3%, 5%, 8%, 10%, 12%, 15%, 18%, 20%, etc.

[0052] This invention has found that by selecting liquid oils, including plant-based liquid oils, and further controlling the oleic acid content in the plant-based liquid oils, the skin barrier can be preserved, thus achieving better repair effects and stability of the product.

[0053] In a preferred embodiment of the skin care composition of the present invention, the mass ratio of the first oil, the second oil and the third oil in the oil is first oil: second oil: third oil = (2-4): (1-5): (1-4).

[0054] For example, the mass ratio of the first oil, the second oil, and the third oil in the oil can be 2:1:1, 2:1:2, 2:1:3, 2:1:4, 2:5:1, 2:5:2, 2:5:3, 2:5:4, 4:1:1, 4:1:2, 4:1:3, 4:1:4, 4:5:1, 4:5:2, 4:5:3, 4:5:4, etc.

[0055] This invention has found that when the first, second, and third oils are compounded in different mass ratios, it not only affects their emulsification effect under the emulsifier, thus affecting the strength and stability of the interfacial film, and consequently the moisturizing effect and storage stability of the product, but also avoids the problem of poor user experience caused by oil stacking. When the mass ratio of the first, second, and third oils is further selected within the above range, the overall effect of the product is even better.

[0056] Preferably, the mass ratio of the first oil, the second oil, and the third oil in the oil is first oil: second oil: third oil = 2:(3-4):(2-3).

[0057] In a second aspect, the present invention provides the use of the skincare composition in the preparation of skincare products.

[0058] The skincare composition provided by this invention has excellent rapid relief of dry skin and long-lasting moisturizing effect, good storage stability and excellent ability to enhance the skin barrier. Moreover, the obtained skincare composition is mild and non-irritating and can be widely used in the preparation of skincare products. The corresponding skincare products have good moisturizing effect, skin barrier strengthening effect and mild and non-irritating characteristics.

[0059] As a preferred embodiment of the application described in this invention, the skin care product includes any one of essence lotion, face cream, and body lotion.

[0060] In a third aspect, the present invention provides a skin care product comprising the following components by weight percentage: 35-55% of the skin care composition of the present invention, 0.02-0.1% of a chelating agent, 0.05-1% of a thickener, 0.05-0.5% of a co-emulsifier, 0.4-0.6% of hexanediol, 0.4-0.6% of p-hydroxyacetophenone, and the balance being water.

[0061] In a preferred embodiment of the skin care product described in this invention, the chelating agent includes disodium EDTA.

[0062] As a preferred embodiment of the skin care product of the present invention, the thickener includes at least one of xanthan gum, sclerotium gum, ammonium acryloyl dimethyl taurate / VP copolymer, and hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer.

[0063] In a preferred embodiment of the skin care product of the present invention, the emulsifier includes at least one of hydrogenated lecithin and hydrogenated phosphatidylcholine.

[0064] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0065] This invention selects specific emulsifier systems, auxiliary agent systems, oil systems, and moisturizers, which are compounded together and have good synergistic effects among the components within the system. As a result, the skin care products obtained from the skin care composition of this invention have excellent rapid relief of dry skin and long-lasting moisturizing effects, and can effectively improve the skin barrier function. In addition, the skin care products obtained are highly gentle, have excellent storage stability, and provide a superior user experience. Attached Figure Description

[0066] Figure 1 The effect is illustrated in Example 2, showing the results of the stimulation test in Example 1.

[0067] Figure 2 The effect is illustrated in Example 2, showing the results of the stimulus test in Example 7.

[0068] Figure 3 The graph shows the results of the stimulation test in Example 13, which is used in the comparison of the effects in Example 2. Detailed Implementation

[0069] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0070] Unless otherwise specified, the reagents, methods and equipment used in this invention are all conventional reagents, methods and equipment in the field; and unless otherwise specified, the raw materials used in parallel experiments are from the same batch.

[0071] Emulsifier 1: A mixture of arachidonic acid glucoside and polyglycerol-6 distearate in a mass ratio of 4:0.8;

[0072] Emulsifier 2: The difference from emulsifier 1 is that the mass ratio of arachidonic acid glucoside and polyglycerol-6 distearate is 2:1.5;

[0073] Emulsifier 3: The difference from emulsifier 1 is that the mass ratio of arachidonic acid glucoside and polyglycerol-6 distearate is 6:0.01;

[0074] Emulsifier 4: The difference from emulsifier 1 is that polyglycerol-4 isostearate is used instead of polyglycerol-6 distearate;

[0075] Emulsifier 5: Arachidyl alcohol glucoside;

[0076] Emulsifier 6: Polyglycerol-6 distearate;

[0077] Emulsifier 7: The difference from emulsifier 1 is that it uses cocoyl glucoside instead of arachidonic acid glucoside.

[0078] Adjuvant 1: A mixture of ceramide EOP, stearic acid and phytosterols [Brassica campestris sterols (purchased from BASF (China) Co., Ltd.)] in a 3:1:1 ratio;

[0079] Additive 2: The difference from Additive 1 is that the mass ratio of ceramide EOP, stearic acid and phytosterol is 1:3:1;

[0080] Adjuvant 3: The difference from adjuvant 1 is that it uses phytosterol macadamia oleate instead of rapeseed (Brassica campestris) sterols;

[0081] Additive 4: The difference from Additive 1 is that it does not contain ceramide EOP;

[0082] Additive 5: The difference from Additive 1 is that it does not contain stearic acid;

[0083] Additive 6: The difference from Additive 1 is that it does not contain phytosterols;

[0084] Additive 7: The difference from Additive 1 is that ceramide NP is used instead of ceramide EOP.

[0085] Oil 1: A mixture of first oil (a mixture of sunflower seed oil and caprylic / capric triglycerides in a 1:4 ratio, wherein the oleic acid content of the sunflower seed oil is ≤20%, purchased from Cargill, Incorporated), second oil (cocoa butter, melting point 25-37℃, purchased from Clariant Chemicals (Shanghai) Co., Ltd.), and third oil (behenol) in a mass ratio of 2:4:3;

[0086] Oil 2: The difference from Oil 1 is that the mass ratio of the first oil, the second oil, and the third oil is 4:1:1;

[0087] Oil 3: The difference between oil 3 and oil 1 is that the first oil is perilla seed oil with an oleic acid content of ≤10% (purchased from Jiangxi Xinsen Natural Plant Oil Co., Ltd.);

[0088] Oil 4: The difference from Oil 1 is that the first oil is sea buckthorn oil with an oleic acid content of ≤10% (purchased from Draco Nature Products);

[0089] Oil 5: The difference from Oil 1 is that cetearyl alcohol is used instead of behenyl alcohol;

[0090] Oil 6: The difference from Oil 1 is that no first oil is added;

[0091] Oil 7: The difference from Oil 1 is that no second oil is added;

[0092] Oil 8: The difference from Oil 1 is that no third oil is added;

[0093] Oil 9: The difference from oil 1 is that stearyl alcohol is used instead of behenyl alcohol.

[0094] Moisturizer 1: Glycerin;

[0095] Moisturizer 2: A mixture of butylene glycol and glycerin in a 1:1 mass ratio;

[0096] Moisturizer 3: Trehalose.

[0097] Examples 1-8 and Comparative Example 1

[0098] The present invention provides a skin care composition in the embodiments and comparative examples, the components (parts by mass) of the skin care composition are shown in Table 1; wherein W1 represents the mass percentage of oil based on the total mass of the skin care composition, W2 represents the mass percentage of auxiliary agents based on the total mass of the skin care composition, and W3 represents the mass ratio of emulsifier to oil;

[0099] Table 1

[0100] Emulsifier 1 Additive 1 Oil 1 Moisturizer 1 W1 / ％ W2 / ％ W3 Example 1 4 0.15 13 3 65 0.7 1:3.25 Example 2 3 0.2 10 1 70 1.4 1:3.30 Example 3 6 0.1 18 4 64 0.4 1:3.00 Example 4 1 0.5 3 5 32 5.3 1:3.00 Example 5 9 0.03 50 1 83 0.05 1:5.56 Example 6 3 0.15 18 3 75 0.6 1:6.00 Example 7 0.5 0.15 1.5 6 18 1.8 1:3.00 Example 8 4 2.0 13 0.5 67 10.3 1:3.25 Comparative Example 1 4 0 13 3 65 0 1:3.25

[0101] Example 9

[0102] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that emulsifier 2 is used instead of emulsifier 1.

[0103] Example 10

[0104] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that emulsifier 3 is used instead of emulsifier 1.

[0105] Example 11

[0106] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that emulsifier 4 is used instead of emulsifier 1.

[0107] Example 12

[0108] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that adjuvant 2 is used instead of adjuvant 1.

[0109] Example 13

[0110] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that adjuvant 3 is used instead of adjuvant 1.

[0111] Example 14

[0112] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that oil 2 is used instead of oil 1.

[0113] Example 15

[0114] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that oil 3 is used instead of oil 1.

[0115] Example 16

[0116] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that oil 4 is used instead of oil 1.

[0117] Example 17

[0118] This invention provides a skincare composition, the only difference between the skincare composition and that of Example 1 is that oil 5 is used instead of oil 1.

[0119] Example 18

[0120] This invention provides a skincare composition, the only difference between the skincare composition and Example 1 is that moisturizer 2 is used instead of moisturizer 1.

[0121] Comparative Example 2

[0122] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that emulsifier 5 is used instead of emulsifier 1.

[0123] Comparative Example 3

[0124] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that emulsifier 6 is used instead of emulsifier 1.

[0125] Comparative Example 4

[0126] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that emulsifier 7 is used instead of emulsifier 1.

[0127] Comparative Example 5

[0128] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that the adjuvant 4 is used instead of adjuvant 1.

[0129] Comparative Example 6

[0130] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that the adjuvant 5 is used instead of adjuvant 1.

[0131] Comparative Example 7

[0132] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that the adjuvant 6 is used instead of adjuvant 1.

[0133] Comparative Example 8

[0134] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that the adjuvant 7 is used instead of adjuvant 1.

[0135] Comparative Example 9

[0136] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that oil 6 is used instead of oil 1.

[0137] Comparative Example 10

[0138] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that oil 7 is used instead of oil 1.

[0139] Comparative Example 11

[0140] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that oil 8 is used instead of oil 1.

[0141] Comparative Example 12

[0142] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that oil 9 is used instead of oil 1.

[0143] Comparative Example 13

[0144] The present invention provides a skin care composition in a comparative example, the only difference between the skin care composition and Example 1 is that moisturizer 3 is used instead of moisturizer 1.

[0145] Application Example 1-19, Comparison with Application Example 1-13 and Blank Application Example

[0146] The present invention provides a skin care product in application examples, comparative application examples, and blank application examples. The components (mass percentage) of the skin care product are shown in Table 2. In application examples 1-18, the skin care compositions used are the skin care compositions prepared in examples 1-18, for example, application example 1 uses the skin care composition from example 1, application example 2 uses the skin care composition from example 2, and so on. In comparative application examples 1-13, the skin care compositions used are the skin care compositions prepared in comparative examples 1-13. In application example 19, the skin care composition used is the skin care composition prepared in example 1.

[0147] Table 2

[0148]

[0149]

[0150] The method for preparing the skincare product provided in Example 1 includes the following steps:

[0151] (1) Add emulsifier, additives and oil to oil phase pot, heat to 85-90℃ with stirring to obtain oil phase;

[0152] (2) Add water, thickener, chelating agent and humectant into an aqueous phase pot, heat to 85°C while stirring, and obtain an aqueous phase;

[0153] (3) Add the oil phase to the aqueous phase, stir evenly, vacuum, and then turn on medium-high speed homogenization for 10 minutes.

[0154] (4) Turn on the cooling water and slowly cool down to 40-45℃. Add the remaining materials, stir evenly, take a sample and send it for inspection. Once it passes the inspection, the product can be discharged to obtain skin care products.

[0155] The preparation methods of the skin care products provided in Application Examples 2-19, Comparative Application Examples 1-13, and Blank Application Examples are consistent with those in Application Example 1. If the relevant components are not available, they can be omitted.

[0156] Example 1

[0157] The present invention investigates the barrier effect and the effect of enhancing the skin barrier function of the skin care products prepared by application examples, comparative application examples and blank application examples.

[0158] 1. Barrier effect

[0159] The physical model was used to test the barrier effect of the sample:

[0160] Experimental Method: The physical model consisted of a 5cm diameter circular transfer filter paper and a PTFE gasket. The experiment was conducted in a constant temperature and humidity chamber under the set temperature and humidity conditions (30℃, 50%). The weight of the blank physical model was recorded as m0. The physical model coated with a quantitative test sample (1.2g sample) was placed on a weighing bottle containing a certain amount of purified water (20g), placed through a 200-mesh sieve, and then placed in the constant temperature and humidity chamber. After 24 hours, the physical model was removed and its weight recorded as m1. The physical model was then dried in an oven at 60℃ for 16 hours. After drying, the physical model was removed, weighed using a microbalance, and its weight recorded as m2. The barrier effect is represented by w, and the calculation formula is as follows:

[0161]

[0162] The results are shown in Table 3.

[0163] 2. Long-lasting moisturizing effect and improved skin barrier function

[0164] The stratum corneum moisture content (MMV value) characterizes the long-lasting moisturizing effect, while the transepidermal water loss (TWEL value) characterizes the repair effect.

[0165] Skincare products prepared using the application example and the control application example were tested on sensitive skin (TEWL ≥ 20g / hm). 2 Six participants in each group were tested for stratum corneum moisture content and transepidermal water loss. On the day of their visit, no products were applied to the test area (face). After washing their faces, participants sat quietly for 20 minutes in a constant temperature and humidity room at 21±1℃ and 50±10% humidity. Transepidermal water loss was measured using a skin transdermal water loss probe. TM Hex (Courage+Khazaka) and Moisture Measurement Probe The CM825 measured the initial TEWL and MMV values ​​of each volunteer's left and right sides of the face and averaged them. Subjects used the skincare product continuously for 28 days, and the TEWL and MMV values ​​of their facial skin were measured again after use.

[0166] TEWL value improvement rate (%) = (initial TEWL value - TEWL value after use) / initial TEWL value × 100%;

[0167] MMV improvement rate (%) = (MMV value after use - initial MMV value) / initial MMV value × 100%;

[0168] A higher TEWL value improvement rate indicates a stronger skin barrier repair ability of the emollient; a higher MMV value improvement rate indicates a better long-lasting moisturizing effect of the emollient. The results are shown in Table 3.

[0169] Table 3

[0170]

[0171]

[0172] As can be seen from Table 3, when the technical solution provided by the present invention is adopted, the obtained skin care product has excellent rapid relief of dry skin and long-lasting moisturizing effect, and can effectively improve the skin barrier function; specifically, the barrier effect w of the obtained skin care product is above 32.5%, and the improvement rate of TEWL value and MMV value is above 20.2% and 38.5%, respectively.

[0173] As can be seen from Application Examples 1-8 and Comparative Application Example 1, the mass fraction of the components and whether or not a certain component is added have a significant impact on product performance. When the mass fraction of the components is further selected within the scope of this invention, the overall effect of the obtained product is better. Specifically, the barrier effect w of the obtained skin care product is above 40.2%, and the improvement rate of TEWL value and MMV value is above 23.5% and 46.2%, respectively. However, when no adjuvant is added in Comparative Application Example 1, the product's ability to improve the skin barrier is significantly reduced, and the barrier effect is also significantly reduced.

[0174] As can be seen from Application Examples 1, 9-11 and Comparative Application Examples 2-4, the choice of emulsifier has a significant impact on the barrier effect, long-lasting moisturizing effect and repair effect; when only one of the emulsifiers is added or other substances are substituted, the effect of the present invention cannot be achieved.

[0175] As can be seen from Application Examples 1, 12-13 and Comparative Application Examples 5-8, the choice of additives has a significant impact on the barrier effect, long-lasting moisturizing effect and repair effect. When no additives are added or other substances are used as substitutes, the barrier effect, long-lasting moisturizing effect and repair effect of the product are significantly reduced.

[0176] As can be seen from Application Examples 1, 14-17 and Comparative Application Examples 9-12, the choice of oil has a significant impact on the barrier effect, long-lasting moisturizing effect and repair effect; when no oil is added or other substances are used as substitutes, the barrier effect, long-lasting moisturizing effect and repair effect of the product are significantly reduced.

[0177] As can be seen from Application Example 1, Application Example 18 and Comparative Application Example 13, the choice of moisturizer directly affects the moisturizing effect, while having a relatively small impact on the barrier and repair effects.

[0178] Example 2

[0179] The efficacy of this invention was investigated by comparing application examples, control examples, and blank application examples to assess the irritation of skincare products prepared using these methods. The process included the following steps:

[0180] The chorioallantoic membrane assay for chicken embryos included the following steps: SPF-grade chicken embryos were incubated for 9 days in an incubator at 37.5℃±0.5℃, 65% humidity, and a rotation frequency of 5 times / h. After incubation, the air cell location was marked, the eggshell was carefully peeled off to expose the white membrane, and the membrane was moistened with 1 mL of physiological saline. The membrane was then carefully removed, taking care to avoid damaging the vascular membrane. A Teflon ring was placed in the yolk region of the chicken embryo, and the embryo was photographed under a stereomicroscope before sample loading. An appropriate amount of emollient was added to the Teflon ring, and a photograph was recorded at 30 minutes. Six chicken embryos were prepared in parallel for each sample.

[0181] Results evaluation: The irritancy of the sample was scored based on the bleeding, coagulation and vascular dissolution phenomena. No bleeding, mild bleeding, moderate bleeding and severe bleeding were scored as 0, 1, 2 and 3 points respectively; no coagulation, mild coagulation, moderate coagulation and severe coagulation were scored as 0, 1, 2 and 3 points respectively; no vascular dissolution, mild vascular dissolution, moderate vascular dissolution and severe vascular dissolution were scored as 0, 1, 2 and 3 points respectively.

[0182] Endpoint score ES calculation formula: ES = Sum of scores corresponding to the degree of hemorrhage, coagulation and vascularization observed in 6 chicken embryos / 3;

[0183] The scoring table is shown in Table 4, and the results are shown in Table 5.

[0184] Table 4

[0185] Finish line score Irritant Classification ES≤12 Non-irritating / mildly irritating 12<ES<16 moderate irritation ES≥16 Severe irritation

[0186] Table 5

[0187]

[0188]

[0189] As can be seen from Table 5, the skincare product obtained using the technical solution of this invention has high gentleness; in Application Example 7, the moisturizer's mass percentage in the skincare composition was too high within the addition range, resulting in relatively high irritation; in Comparative Application Example 13, when the moisturizer was changed in the skincare composition, the irritation of the resulting skincare product also increased significantly. Specifically, photographs of any one chicken embryo from Application Example 1, Application Example 7, and Comparative Application Example 13 are shown below. Figure 1-3 As shown.

[0190] Example 3

[0191] The stability of skincare products prepared using the present invention in application examples, comparative application examples, and blank application examples includes the following steps:

[0192] Skincare products prepared according to the corresponding use cases and comparative application examples were subjected to heat resistance, cold resistance, thermal cycling, light exposure, and centrifugation tests. The heat resistance requirements were: maintaining (40±1)℃ for 3 months without stratification after returning to room temperature; the cold resistance requirements were: maintaining -15℃ for 1 month without stratification after returning to room temperature; no stratification after 3 thermal cycling cycles (-15℃~25℃~45℃); no discoloration or odor change after 1 month of light exposure (light aging chamber); and no stratification after 3000 r / m for 30 min at 3000 rpm. The results are shown in Table 6.

[0193] Table 6

[0194]

[0195]

[0196] As can be seen from Table 6, the skin care products obtained by using the technical solution provided by the present invention have excellent stability, while the stability of solutions other than those of the present invention will show a certain degree of abnormality.

[0197] Finally, it should be noted that the above embodiments are used to illustrate the technical solutions of the present invention and not to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A gentle moisturizing skincare composition, characterized in that, The skin care composition comprises the following components in parts by weight: 1-9 parts emulsifier, 0.03-0.5 parts auxiliary agent, 3-50 parts oil, and 1-5 parts moisturizer; The emulsifiers include arachidonic acid glucoside and polyglycerol fatty acid esters; The adjuvants include ceramide EOP, stearic acid, and phytosterols; The grease includes a first grease, a second grease, and a third grease. The first grease includes a liquid grease, the second grease includes a natural semi-solid grease with a melting point of 25-52°C, and the third grease includes at least one of cetearyl alcohol and behenyl alcohol. The humectant includes polyols; The liquid oils include vegetable-based liquid oils and synthetic liquid oils.

2. The skincare composition according to claim 1, characterized in that, The oil comprises 32-83% by mass of the total mass of the skincare composition. And / or, based on the total mass of the skincare composition, the mass percentage of the adjuvant is 0.05-5.3%; And / or, the mass ratio of the emulsifier to the oil is 1:(3.0-10); And / or, in the emulsifier, the mass ratio of arachidonic acid glucoside to polyglycerol fatty acid ester is (2-6):(0.01-1.5); And / or, in the adjuvant, the mass ratio of ceramide EOP, stearic acid and phytosterol is ceramide EOP: stearic acid: phytosterol = 3: (0.5-1.5): (0.5-1.5).

3. The skincare composition according to claim 1, characterized in that, The polyglycerol fatty acid ester includes at least one of polyglycerol-3 diisostearate, polyglycerol-4 isostearate, and polyglycerol-6 distearate; And / or, the phytosterols include at least one of β-sitosterol, brassosterols, and phytosterol macadamia oleate.

4. The skincare composition according to claim 3, characterized in that, The plant-based liquid oils include at least one of the following: perilla seed oil, meadowfoam seed oil, sunflower seed oil, milk thistle seed oil, sea buckthorn fruit oil, borage oil, rice bran oil, and squalane. And / or, the synthetic liquid fat includes at least one of caprylic / capric triglyceride, polydimethylsiloxane, triglyceride (ethylhexanoate), and pentaerythritol tetra(ethylhexanoate); And / or, the natural semi-solid fats with a melting point of 25-52°C include at least one of shea butter, cocoa seed butter, jojoba esters, and muruman seed butter.

5. The skincare composition according to claim 3, characterized in that, In the first oil, the ratio of vegetable liquid oil to synthetic liquid oil is 1:(3-5); And / or, in the vegetable liquid oil, the mass percentage of oleic acid is ≤20%.

6. The skincare composition according to claim 1, characterized in that, The mass ratio of the first oil, the second oil and the third oil in the oil is first oil: second oil: third oil = (2-4): (1-5): (1-4).

7. The use of the skincare composition according to any one of claims 1-6 in the preparation of skincare products.

8. A skincare product, characterized in that, The skin care product comprises the following components by weight percentage: 35-55% of the skin care composition as described in any one of claims 1-6, 0.02-0.1% chelating agent, 0.05-1% thickener, 0.05-0.5% co-emulsifier, 0.4-0.6% hexanediol, 0.4-0.6% p-hydroxyacetophenone, and the balance being water.

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