Traditional Chinese medicine composition for treating sphagitis through medicine blowing method
By using a particle size controllable traditional Chinese medicine composition preparation technology, the problems of drugs being difficult to penetrate deep into the throat and being highly irritating in the inhalation therapy have been solved, achieving precise drug delivery and long-term treatment for pharyngitis, and improving patient comfort and treatment effectiveness.
Patent Information
- Application Number
- CN202511309203.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-15
- Publication Date
- 2025-11-07
AI Technical Summary
Current inhalation therapy uses drugs with large particle sizes, making it difficult to penetrate deep into the throat. This results in high irritation, lack of mucosal repair function, poor patient compliance, and difficulty in simultaneously achieving anti-inflammatory and mucosal barrier reconstruction.
A traditional Chinese medicine composition was prepared by using a combination of green plum powder with controllable particle size, cyclodextrin-menthol inclusion complex, beeswax, Ophiopogon japonicus polysaccharide and lactose, through low-temperature mixing and freeze-drying. By combining cyclodextrin inclusion technology and the mucosal protective effect of beeswax, a bioadhesive membrane was formed to achieve precise drug delivery and long-lasting efficacy.
It achieves precise drug delivery deep into the throat, extends the duration of drug efficacy to 4-6 hours, reduces the coughing rate to below 5%, and has the functions of clearing heat and relieving sore throat, repairing mucosa and antibacterial, thus improving patient comfort.
Abstract
Description
TECHNICAL FIELD
[0002] The present application relates to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine. BACKGROUND
[0003] Pharyngolaryngitis is a common upper respiratory tract disease in clinic, which is classified into categories such as 'laryngalgia' and 'laryngalgia' in traditional Chinese medicine, and is caused by wind-heat evil invasion, lung and stomach heat or yin deficiency and fire, and is clinically manifested as symptoms such as pharyngeal swelling and pain, dry and hot throat, hoarse voice and the like. The blowing medicine therapy, as a characteristic external treatment method for treating pharyngolaryngitis in traditional Chinese medicine, has the advantages of rapid effect, high local drug concentration and small systemic side effects, and has become an important way for the auxiliary treatment of mild pharyngolaryngitis and chronic pharyngolaryngitis.
[0004] However, the current market drug components and preparation processes for blowing medicine therapy have many deficiencies: firstly, traditional Chinese medicine powders mostly adopt simple crushing and mixing process, and the drug particle size is coarse, which is difficult to enter the deep lesion of the throat with respiratory airflow, and the absorption efficiency is low, and the drug effect is limited; secondly, some drugs contain irritating components such as borneol, and lack of compatibility design for relieving irritation, and blowing medicine can easily cause patients to cough, nausea and other discomfort, and the patient compliance is poor; thirdly, there is a lack of special design for repairing the pharyngeal mucosa, and it is difficult to meet the dual needs of anti-inflammatory and mucosal barrier reconstruction. SUMMARY
[0005] The present application aims to overcome the above technical problems and / or other potential problems in the prior art: to provide a blowing medicine therapy traditional Chinese medicine composition with controllable particle size, small irritation, long-lasting drug effect and functions of anti-inflammatory, repair and antibacterial.
[0006] The technical solution of the present application is as follows: a traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine, comprising the following components in weight parts: 15-18 parts of green fruit powder, 7-9 parts of cyclodextrin menthol inclusion compound, 0.1-0.2 parts of eucalyptus essential oil, 4-6 parts of beeswax, 9-11 parts of radix ophiopogonis polysaccharide and 48-52 parts of lactose.
[0007] As an optimization, the green fruit powder is a freeze-dried green fruit powder with active ingredients of oleuropein or a freeze-dried green fruit extract prepared by a low-temperature extraction process.
[0008] As an optimization, the active ingredient of oleuropein in the green fruit powder is ≥5wt%.
[0009] As an optimization, the average particle size of the green fruit powder is 30-50μm.
[0010] As an optimization, in the cyclodextrin menthol inclusion compound, the inclusion rate of menthol is ≥80%, and the cyclodextrin is β-cyclodextrin or hydroxypropyl-β-cyclodextrin.
[0011] As optimization, the average particle size of the beeswax is 20-50 μm.
[0012] As optimization, the average particle size of the ophiopogon polysaccharide is 10-30 μm.
[0013] As optimization, the average particle size of the lactose is 1-5 μm.
[0014] The application also provides a preparation method of the traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine, comprising the following steps: putting the green fruit powder, the cyclodextrin menthol inclusion compound, the beeswax, the ophiopogon polysaccharide and the lactose into a sterile mixer, stirring for 25-35 minutes at a low temperature of 20-25℃ until they are uniformly dispersed; then slowly adding the eucalyptus oil and continuing to stir for 5-15 minutes, to prepare the traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine through freeze-drying.
[0015] The application also provides an application of the traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine, characterized in that the medicine is administered by blowing medicine, and the single administration dose is controlled to be 0.4-0.6 g.
[0016] The application has the following beneficial effects: the application is suitable for precise administration of deep lesions of pharyngolaryngitis by blowing medicine; meanwhile, through scientific compounding, the traditional Chinese medicine composition has the multiple effects of clearing heat and benefiting the throat, repairing the mucosa and targeted antibiosis, the drug efficacy lasts for 4-6 hours, and the incidence of coughing and choking is reduced to less than 5%. The menthol powder prepared by using the cyclodextrin inclusion technology and combined with the mucosa protective effect of the beeswax reduces the incidence of coughing and choking during blowing medicine from the conventional 20% to less than 5%, and improves the comfort of patients; the biological adhesive film formed by the beeswax and the lactose can make the medicine stay on the mucosa for 2-3 hours, and the overall drug efficacy lasts for 4-6 hours; the green fruit powder clears heat and benefits the throat, the ophiopogon polysaccharide generates saliva and moistens dryness, and the eucalyptus oil nanoemulsion targets antibiosis, and the three components have the triple effects of anti-inflammation, repair and antibiosis, and especially have good inhibitory effect on drug-resistant pathogenic bacteria. DETAILED DESCRIPTION
[0017] The technical solutions of the application will be clearly and completely described below in combination with the embodiments. Obviously, the described embodiments are only part of the embodiments of the application, rather than all the embodiments of the application.
[0018] In the following embodiments, the freeze-dried green fruit powder with an average particle size of 30-50 μm is used, and the active ingredient of oleuropein is ≥5 wt%; the cyclodextrin menthol inclusion compound is a water-soluble menthol inclusion compound produced by Shandong Zhonghuanzhongjie Biological Technology Co., Ltd.; the average particle size of the beeswax is 20-50 μm; the average particle size of the ophiopogon polysaccharide is 10-30 μm; and the average particle size of the lactose is 1-5 μm.
[0019] Example 1 Components and parts: green fruit powder 15 g, cyclodextrin menthol inclusion compound 7 g, eucalyptus essential oil 0.1 g, beeswax 4 g, ophiopogon polysaccharide 9 g, lactose 48 g.
[0020] Preparation method: the above green fruit powder, cyclodextrin menthol inclusion compound, beeswax, ophiopogon polysaccharide and lactose are put into a sterile mixer, stirred at 20°C for 25 minutes until evenly dispersed; then slowly add eucalyptus essential oil and continue stirring for 5 minutes, and the traditional Chinese medicine composition is prepared by freeze-drying.
[0021] Example 2 Components and parts: green fruit powder 16.5 g, cyclodextrin menthol inclusion compound 8 g, eucalyptus essential oil 0.15 g, beeswax 5 g, ophiopogon polysaccharide 10 g, lactose 50 g.
[0022] Preparation method: the above green fruit powder, cyclodextrin menthol inclusion compound, beeswax, ophiopogon polysaccharide and lactose are put into a sterile mixer, stirred at 22.5°C for 30 minutes until evenly dispersed; then slowly add eucalyptus essential oil and continue stirring for 10 minutes, and the traditional Chinese medicine composition is prepared by freeze-drying.
[0023] Example 3 Components and parts: green fruit powder 18 g, cyclodextrin menthol inclusion compound 9 g, eucalyptus essential oil 0.2 g, beeswax 6 g, ophiopogon polysaccharide 11 g, lactose 52 g.
[0024] Preparation method: the above green fruit powder, cyclodextrin menthol inclusion compound, beeswax, ophiopogon polysaccharide and lactose are put into a sterile mixer, stirred at 25°C for 35 minutes until evenly dispersed; then slowly add eucalyptus essential oil and continue stirring for 15 minutes, and the traditional Chinese medicine composition is prepared by freeze-drying.
[0025] Example 4 Components and parts: green fruit powder 16 g, cyclodextrin menthol inclusion compound 7.5 g, eucalyptus essential oil 0.12 g, beeswax 4.5 g, ophiopogon polysaccharide 9.5 g, lactose 49 g.
[0026] Preparation method: the above green fruit powder, cyclodextrin menthol inclusion compound, beeswax, ophiopogon polysaccharide and lactose are put into a sterile mixer, stirred at 21°C for 28 minutes until evenly dispersed; then slowly add eucalyptus essential oil and continue stirring for 8 minutes, and the traditional Chinese medicine composition is prepared by freeze-drying.
[0027] Example 5 Components and weight parts: green fruit powder 17 g, cyclodextrin menthol inclusion compound 8.5 g, eucalyptus essential oil 0.18 g, beeswax 5.5 g, ophiopogon polysaccharide 10.5 g, lactose 51 g.
[0028] Preparation method: the above green fruit powder, cyclodextrin menthol inclusion compound, beeswax, ophiopogon polysaccharide and lactose are put into a sterile mixer, stirred at 24 DEG C for 32 minutes until uniformly dispersed; then eucalyptus essential oil is slowly added and stirred for 12 minutes, and a traditional Chinese medicine composition is prepared by freeze-drying.
[0029] The drug efficacy duration of the application is 4-6 hours, and the incidence of coughing is reduced to less than 5%. The menthol powder is prepared by using cyclodextrin inclusion technology, and the mucous membrane protection effect of beeswax is combined to reduce the coughing rate during blowing from the conventional 20% to less than 5%. The drug components of the application are significantly superior to conventional drugs in treatment effect and use comfort.
[0030] The above examples are only used to illustrate the technical solutions of the application, and not to limit it. Any changes, modifications, substitutions, combinations and simplifications made without departing from the spirit and principles of the application shall be equivalent replacement modes and shall be included in the protection scope of the application.
Claims
1. A traditional Chinese medicine composition for treating pharyngolaryngitis by blowing medicine, characterized in that, The composition comprises the following components by weight: 15-18 parts of Canarium album powder, 7-9 parts of cyclodextrin menthol inclusion compound, 0.1-0.2 parts of eucalyptus oil, 4-6 parts of beeswax, 9-11 parts of Ophiopogon japonicus polysaccharide, and 48-52 parts of lactose.
2. The throat inflammation treating traditional Chinese medicine composition of claim 1, wherein, The Canarium album powder is lyophilized Canarium album powder with an active ingredient of oleuropein or lyophilized Canarium album extract prepared by a low-temperature extraction process.
3. The throat inflammation treating traditional Chinese medicine composition of claim 2, characterized in that, The active ingredient of oleuropein in the Canarium album powder is ≥ 5wt%.
4. The throat inflammation treating traditional Chinese medicine composition of claim 3, characterized in that, The average particle size of the Canarium album powder is 30-50μm.
5. The throat inflammation treating traditional Chinese medicine composition of claim 4, characterized in that, In the cyclodextrin menthol inclusion compound, the inclusion rate of menthol is ≥ 80wt%, and the cyclodextrin is β-cyclodextrin or hydroxypropyl-β-cyclodextrin.
6. The throat inflammation treating traditional Chinese medicine composition of claim 5, wherein, The average particle size of the beeswax is 20-50μm.
7. The throat inflammation treating traditional Chinese medicine composition of claim 6, characterized in that, The average particle size of the Ophiopogon japonicus polysaccharide is 10-30μm.
8. The throat inflammation treating traditional Chinese medicine composition of claim 7, characterized in that, The average particle size of the lactose is 1-5μm.
9. A method for preparing the traditional Chinese medicine composition for treating pharyngolaryngitis by the method of blowing medicine according to any one of claims 1-8, characterized in that, The method comprises the following steps: putting the Canarium album powder, cyclodextrin menthol inclusion compound, beeswax, Ophiopogon japonicus polysaccharide, and lactose into a sterile mixer, stirring at a low temperature of 20-25℃ for 25-35 minutes until they are uniformly dispersed; then slowly adding the eucalyptus oil and continuing to stir for 5-15 minutes to prepare a traditional Chinese medicine composition for treating pharyngolaryngitis by the blowing method.
10. The use of the traditional Chinese medicine composition of any one of claims 1-8 for treating pharyngolaryngitis by the blowing method. The blowing method is used for administration, and the single administration dose is controlled to be 0.4-0.6g.