Traditional Chinese medicine composition for treating male hormone alopecia

Abstract

The invention provides a traditional Chinese medicine composition for treating male hormone alopecia. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 1.5-3 parts of prepared polygonum multiflorum, 1.5-3 parts of scalded rhizoma drynariae, 0.5-1.5 parts of liquorice tablets, 2.5-3 parts of raw cacumen biotae, 2.5-3 parts of salvia miltiorrhiza, 1.5-3 parts of angelica sinensis and 1-2 parts of ligusticum chuanxiong hort. The traditional Chinese medicine composition is obtained by soaking in cold water for 20-30 minutes, decocting and concentrating. The traditional Chinese medicinal materials capable of activating blood circulation, removing blood stasis, nourishing essence and blood and resisting inflammation and allergy are adopted as raw materials, so that the traditional Chinese medicinal composition has multiple effects of activating blood circulation, improving blood circulation and nourishing hair follicles, and the alopecia is cured from the perspective of permanent cure; the traditional Chinese medicines synergistically exert a curative effect, so that the traditional Chinese medicine can nourish hair, prevent alopecia, diminish inflammation and moisten skin.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating androgenetic alopecia. BACKGROUND

[0002] Androgenetic alopecia (androgenetic alopecia, androgenetic alopecia) is also called androgenetic alopecia, seborrheic alopecia, seborrheic alopecia, early alopecia, androgenetic alopecia, male pattern hair loss, hereditary hair loss, etc. It is mainly caused by genetic factors and the attack of dihydrotestosterone (DHT) on hair follicles, leading to miniaturization of hair follicles and disorder of hair cycle.

[0003] Traditional Chinese medicine has been used to treat androgenetic alopecia for a long time. For example, a patent with application number CN202411935165.8 discloses a traditional Chinese medicine active composition for improving anti-hair loss efficiency, which comprises the following components: 8-10% of cypress leaves, 1-3% of radix polygoni multiflori, 1-3% of ginseng, 13% of sophora, 1-3% of chuanxiong, 78-88% of deionized water. However, the prescription focuses on prevention, and the amount and compatibility of the monarch, minister, and assistant drugs cannot cure both the symptoms and the root cause. Although the patent with application number 202411261511.9 discloses an anti-hair loss traditional Chinese medicine composition, which comprises the following components by weight: 20-50 parts of prepared radix polygoni multiflori, 20-50 parts of cypress leaves, 5-30 parts of lemnaceae, 10-30 parts of radix ophiopogonis, 10-30 parts of rhizoma chuanxiong, 10-30 parts of radix alismatis, 10-35 parts of cortex lycii, 15-40 parts of drynaria, 10-40 parts of large sojae semen, and 5-40 parts of forsythia. However, the patent only verifies the external use effect, and does not prove the treatment effect of the prescription from the levels of hormone and inflammation in the body. In addition, the Chinese patent with application number CN202211050850.3 discloses a traditional Chinese medicine composition, its preparation method and application, and specifically discloses a traditional Chinese medicine composition for promoting hair growth and assisting in the treatment of hair loss. The traditional Chinese medicine composition for treating hair loss is made of the following raw materials: 0.01-15 parts of black sesame, 2.5-100 parts of radix polygoni multiflori, 2.5-100 parts of euphorbia humifusa, 2.5-100 parts of cypress leaves, 0.4-10 parts of lycianthes, 2.5-100 parts of radix bupleuri, 1.5-60 parts of radix scrophulariae, 1.5-60 parts of cortex phellodendri, 1.5-50 parts of ramulus cinnamomi, 0.75-30 parts of panax notoginseng, 0.75-30 parts of olibanum, and 0.075-3 parts of saffron. However, the above-mentioned composition still has some disadvantages, such as too many medicinal herbs, complex compatibility, complicated preparation process, difficult quality control, and difficult clinical application. In addition, some of the medicinal herbs are cold or warm in nature, and long-term use may burden the function of the spleen and stomach, which has certain limitations for the suitable population.

[0004] In summary, various traditional Chinese medicine combinations have advantages and disadvantages, how to reasonably match the combination, and avoid the side effects and adverse reactions of drugs on the skin, and effectively treat androgenic alopecia are the difficulties in the design of traditional Chinese medicine formula. SUMMARY

[0005] The object of the present application is to provide a traditional Chinese medicine compound to overcome the defects of the reasonable matching combination of the background art for treating androgenic alopecia.

[0006] In order to achieve the above object, the present application adopts the following technical scheme:

[0007] In the first aspect, the present application provides a traditional Chinese medicine composition for treating androgenic alopecia, which is prepared by matching the following raw medicinal materials by weight: Rhei Radix et Rhizoma 1.5-3 parts, Dipsaci Radix 1.5-3 parts, Glycyrrhizae 0.5-1.5 parts, Cacumen Platycladi 2.5-3 parts, Salviae Miltiorrhizae 2.5-3 parts, Angelicae Sinensis 1.5-3 parts, and Chuanxiong 1-2 parts.

[0008] As a preferred embodiment, the traditional Chinese medicine composition is prepared by matching the following raw medicinal materials by weight:

[0009] Rhei Radix et Rhizoma 2 parts, Dipsaci Radix 2 parts, Glycyrrhizae 1 part, Cacumen Platycladi 3 parts, Salviae Miltiorrhizae 3 parts, Angelicae Sinensis 2 parts, and Chuanxiong 1.5 parts.

[0010] In the second aspect, the present application provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:

[0011] After the traditional Chinese medicine is weighed by weight, it is soaked in cold water for 20-30 min, then decocted at 110℃, and concentrated by heating to obtain the traditional Chinese medicine composition.

[0012] In the third aspect, the present application provides the use of the traditional Chinese medicine composition in the preparation of a medicine for treating androgenic alopecia.

[0013] In the fourth aspect, the present application provides a medicine preparation for treating androgenic alopecia, which is prepared by using the traditional Chinese medicine composition.

[0014] The main pathogenesis of alopecia is the dysfunction of internal organs (especially the liver, kidney and spleen) and the imbalance of qi and blood. "Hair is the residue of blood", and if the qi and blood are deficient, they cannot nourish the hair, and the hair root will lose its nourishment and fall off. The body with blood heat and dry heat is good at damaging yin blood, and the hair root will lose its nourishment and fall off. Therefore, the core idea of the traditional Chinese medicine compound provided by the present application is to nourish blood, activate blood, cool blood and fix hair, and supplement the liver and kidney. First, angelica is a saint medicine for tonifying blood and activating blood, and is directly used for supplementing yin blood; hair is the residue of blood, and if the blood is sufficient, the hair will be moist and nourished, and the blood circulation of the scalp is improved to supply nutrients to the hair follicles. The prepared radix polygoni multiflori is used to supplement the liver and kidney, which is the root of hair, and to benefit essence and blood, blacken the beard and hair, and consolidate the foundation of hair growth. The two are used as the monarch drug, and are the core force of tonifying blood and benefiting essence. Salvia miltiorrhiza can activate blood and remove blood stasis, cool blood and calm the nerves, and assist angelica to enhance the effect of activating blood and removing blood stasis, so that the tonifying medicine can reach the hair root smoothly. As a guide drug, chuanxiong ascending is an excellent guide, and is mainly used for activating blood and promoting qi, dispelling wind and relieving pain, leading the drug force to the scalp lesion, and effectively improving the local qi and blood circulation of the scalp. Gusuibu can activate blood and heal injury, and can supplement the kidney and strengthen the bone. It is warm and unblocked, and can activate blood to promote hair follicle metabolism; at the same time, it enters the kidney meridian, and warms and supplements kidney yang, which is warm and flat with radix polygoni multiflori, and supplements kidney qi together. Salvia miltiorrhiza, chuanxiong and gusuibu are all ministerial drugs, and are used to assist and enhance the efficacy. Cacumen platycladi can cool blood and stop bleeding, and grow hair and blacken hair, which is a key auxiliary drug for treating alopecia (especially blood heat type alopecia); it is cold and cool, and can clear blood heat, and reduce the oily, itching and falling off of the scalp caused by blood heat and dry wind. Licorice tablets can benefit qi and supplement the middle, assist the source of blood and qi, and clear heat and detoxify, which can help cacumen platycladi to clear heat and detoxify, and adjust the properties of various drugs. Cacumen platycladi and licorice tablets are both auxiliary drugs, and coordinate the properties of drugs. In summary, the traditional Chinese medicine compound can effectively treat alopecia, nourish hair follicles, have anti-inflammatory and anti-allergic effects, and can be taken orally and used externally.

[0015] The compatibility idea and uniqueness of the medicine provided by the present application are as follows:

[0016] First, the combination of tonifying blood and activating blood: angelica and radix polygoni multiflori tonify blood, and salvia miltiorrhiza and chuanxiong actively activate blood, which embodies the thoughts of "treating wind by treating blood first, and blood running wind disappearing" and "tonifying blood without leaving stasis". The blood is sufficient and runs smoothly, and the hair root can be fully nourished. Second, both treating the symptoms and treating the root: using cacumen platycladi to clear heat and cool blood to solve the "evil" of blood heat which directly leads to alopecia to treat the symptoms; using radix polygoni multiflori and gusuibu to supplement the liver and kidney, and angelica to tonify blood, which starts from the root problem of liver and kidney qi and blood to treat the root. Third, ascending and guiding meridian in parallel: chuanxiong is a "meridian guiding drug", which is like a guide to ensure that the power of the whole medicine can be concentrated on the head. Fourth, cold and warm are used together: there are cacumen platycladi and salvia miltiorrhiza in the medicine, and there are chuanxiong, gusuibu and licorice to adjust them, so that the properties of the whole medicine are moderate, not cold or dry, and suitable for long-term conditioning.

[0017] Compared with the prior art, the present application has the following advantages:

[0018] The raw materials of the application are all from the Chinese Pharmacopoeia, and the key is to use traditional Chinese medicinal materials with the functions of activating blood to remove blood stasis, nourishing essence and blood, and resisting inflammation and allergy as raw materials, which have multiple effects of activating blood to improve blood circulation and nourishing hair follicles, and cure alopecia from the root; the above drugs synergistically play a curative effect, which can not only nourish hair, but also prevent hair loss, inflammation and skin moisturizing. The prescription takes nourishing blood and activating blood as the foundation, tonifying liver and kidney as the basis, and clearing heat and cooling blood to treat symptoms. The core is to dredge, clean and nourish the body through multiple channels to create an internal environment suitable for hair growth (rich in qi and blood, good circulation) and scalp environment (no heat, no stasis, no wind). The animal experiment verifies that the effects effectively overcome the various defects described in the background art. The traditional Chinese medicine composition prepared by the application can be directly applied to the head during use, effectively acting on the head, slowing down the disease progression, promoting hair growth, and being very convenient to prepare and use. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 The hair growth of mice in different experimental groups.

[0020] Figure 2 The testosterone and estrogen levels in the serum of mice in different experimental groups.

[0021] Figure 3 The expression levels of inflammatory factors in the back tissues of mice in different experimental groups.

[0022] Figure 4 The expression levels of apoptosis-related factors in the back tissues of mice in different experimental groups. DETAILED DESCRIPTION

[0023] The application will be further described below in combination with examples and drawings.

[0024] Example 1: Preparation of traditional Chinese medicine composition

[0025] Each traditional Chinese medicine is weighed according to the following weight: Radix Polygoni Multiflori 280g, Radix Dipsaci 280g, Glycyrrhiza slice 140g, Radix Platycladi 420g, Radix Salviae Miltiorrhizae 420g, Radix Angelicae Sinensis 280g, and Radix et Rhizoma Notoginseng 210g.

[0026] The prepared medicinal materials are placed in a special decoction bag, and the bag opening is tightly tied; the decoction bag is placed in a decoction pot, and a proper amount of cold water is added to soak the medicinal materials for 30 minutes; after soaking is completed, the pot cover is covered, and decoction is carried out at 110℃; after decoction is completed, the medicinal bag is mechanically squeezed by the decoction machine to improve the extraction rate of the medicinal liquid; finally, the mixed medicinal liquid is heated and concentrated to obtain the traditional Chinese medicine composition, which is used as the medicine of the subsequent traditional Chinese medicine treatment group.

[0027] Example 2: The significant therapeutic effect of the traditional Chinese medicine preparation on the mouse AGA animal model is verified by establishing the model.

[0028] This embodiment uses a total of 45 C57BL / 6 male mice, which are divided into 5 groups, with 9 mice in each group: a healthy control group, a model group, a minoxidil treatment group, a low-dose traditional Chinese medicine treatment group, and a high-dose traditional Chinese medicine treatment group.

[0029] Testosterone is dissolved in the healthy control group, which is treated with daily gavage of normal saline and normal saline application on the back skin. The model group is treated with daily testosterone application and normal saline gavage. The minoxidil treatment group is treated with daily testosterone application, minoxidil application, and normal saline gavage. The low-dose traditional Chinese medicine treatment group is treated with daily testosterone application and 0.1 mL of traditional Chinese medicine composition mixed with 0.1 mL of drinking water gavage. The high-dose traditional Chinese medicine treatment group is treated with daily testosterone application and 0.2 mL of traditional Chinese medicine composition gavage. The mice are grouped and fed for 28 days.

[0030] After the animal modeling and treatment are completed, 3 mice are randomly selected from each group for back tissue sampling, and the eyeballs are removed for blood collection. Finally, the mouse carcasses are properly disposed of.

[0031] The testosterone levels and estrogen levels in the serum of each group of mice are detected.

[0032] The expression levels of inflammatory factors in the back tissues of each group of mice are detected.

[0033] The expression levels of apoptosis-related factors in the back tissues of various mice are detected.

[0034] Experimental results:

[0035] As shown in Figure 1 , it can be seen that the hair growth of the mice in the model group is the slowest, while the hair growth of the mice in the minoxidil treatment group and the high-dose traditional Chinese medicine treatment group is the most significant.

[0036] As shown in Figure 2 , the experimental results show that compared with the AGA model group (DHT group), the DHT concentration in the serum of the AGA mice is significantly down-regulated after the traditional Chinese medicine treatment, and the treatment effect of the high-dose traditional Chinese medicine treatment group is the best. At the same time, the E2 concentration in the serum of the AGA mice is significantly up-regulated after the traditional Chinese medicine treatment, and the high-dose traditional Chinese medicine treatment group is closer to the level of the healthy control group. Combined with the hair growth of each group, it is shown that the traditional Chinese medicine compound treatment effectively relieves the hair loss of the mice by regulating the balance of estrogen and androgen in the body of the mice.

[0037] As shown in Figure 3 , the mRNA of the inflammatory factors in the skin tissues of the AGA model group and the protein concentration of the inflammatory factors in the serum are both significantly up-regulated, and after the minoxidil treatment and the traditional Chinese medicine treatment, they all show a downward trend, among which the treatment effect of the high-dose traditional Chinese medicine treatment group is obvious. In summary, the traditional Chinese medicine compound has obvious relief effect on the inflammation caused by the AGA of the mice.

[0038] As shown in Figure 4 Compared with the AGA model group, after the treatment of traditional Chinese medicine, the mRNA expression levels of Bax and caspase9 in the skin tissues of AGA mice were significantly down-regulated, and the mRNA expression level of Bcl-2 was significantly up-regulated, which indicated that the apoptosis of skin cells was significantly inhibited by the treatment of traditional Chinese medicine, and the treatment effect of the high-dose treatment group was the best.

[0039] Based on all the experimental results above, it is shown that the traditional Chinese medicine compound in the application has a significant treatment effect in regulating the balance of estrogen and androgen and anti-inflammation.

Claims

1. A traditional Chinese medicine composition for treating androgenetic alopecia, characterized in that, The Chinese medicine composition is prepared by compounding the following raw medicine materials by weight: Radix Polygoni Multiflori Praeparata 1.5-3 parts, Radix Dipsaci 1.5-3 parts, Glycyrrhiza slices 0.5-1.5 parts, Radix Platycladi 2.5-3 parts, Radix Salviae Miltiorrhizae 2.5-3 parts, Angelica 1.5-3 parts, and Radix et Rhizoma Notoginseng 1-2 parts.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The Chinese medicine composition is prepared by compounding the following raw medicine materials by weight: Radix Polygoni Multiflori Praeparata 2 parts, Radix Dipsaci 2 parts, Glycyrrhiza slices 1 part, Radix Platycladi 3 parts, Radix Salviae Miltiorrhizae 3 parts, Angelica 2 parts, and Radix et Rhizoma Notoginseng 1.5 parts.

3. The preparation method of the traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The preparation method comprises the following steps: The Chinese medicine is weighed by weight parts, then soaked in cold water, and then decocted at 110℃, and concentrated by heating to obtain the Chinese medicine composition.

4. The production method according to claim 2, characterized by, The Chinese medicine is soaked and decocted in a decoction bag, and the decoction bag is squeezed after decoction to improve the extraction rate of the medicinal liquid.

5. The preparation method according to claim 2, characterized in that, The cold water soaking time is 20-30 min.

6. Use of the Chinese medicine composition of claim 1 in the preparation of a medicine for treating androgenic alopecia.

7. A pharmaceutical preparation for the treatment of androgenetic alopecia, characterized in that, The Chinese medicine composition is prepared by using the Chinese medicine composition of claim 1 or 2.

Images